Chron Respir Dis [JOURNAL]
Sun
200 papers
Associations of social isolation and loneliness with the risk of adult-onset asthma: A prospective cohort and mendelian randomization study.
Zhang J, Li Y, Sun X … +7 more , An R, Zhang H, Gong J, Zhang Y, Li Y, Gu Y, Xia Y
Chron Respir Dis · 2026 · PMID 41774051 · Full text
BackgroundDespite proposed aetiological mechanisms involving stress-induced inflammation and behaviour, population-level evidence linking social isolation and loneliness to asthma is lacking. Therefore, we aimed to exami...
BackgroundDespite proposed aetiological mechanisms involving stress-induced inflammation and behaviour, population-level evidence linking social isolation and loneliness to asthma is lacking. Therefore, we aimed to examine the associations of social isolation, loneliness, and genetic predisposition with asthma risk in middle-aged and older adults, and to quantify the contribution of various risk factors.MethodsA total of 400,184 asthma-free participants were enrolled from the UK Biobank. Loneliness was evaluated using the short form of the Revised UCLA Loneliness Scale, and social isolation was assessed through a composite score based on key social network components. Asthma was evaluated using hospital inpatient records in UK Biobank. Genetic predisposition for asthma was characterized using weighted polygenic risk score (PRS). Cox proportional hazard models were utilized to assess the associations of social isolation and loneliness with the risk of asthma. The one-sample Mendelian randomization (MR) analysis was based on genome-wide association studies of UKB.ResultsOver an 11.6-years median follow-up, a total of 9453 new asthma cases were recorded. In the fully adjusted model, individuals with feelings of loneliness had a 1.27-fold higher risk of asthma (95% CI: 1.15-1.39) than those without. However, social isolation showed no significant association with asthma risk after several factor adjustments. No significant interactions of loneliness and asthma-PRS were detected. In the one-sample MR analyses, we observed suggestive genetic evidence supporting associations of feeling lonely, fewer leisure social activities, being willing to confide in others, and participating in more other group activities with asthma.ConclusionsOur findings suggest that loneliness, but not social isolation is a risk factor for asthma that is independent of various factors and genetic predisposition. Mendelian randomization provides suggestive evidence that loneliness and reduced social activity may be causal risk factors for asthma.
Exploration of health inequalities in patients treated with home non-invasive ventilation - Associations with respiratory healthcare burden.
Milczanowska WN, Rajkumar A, Williamson NJ … +4 more , Falade O, Elliott L, Patel AS, Lee KK
Chron Respir Dis · 2026 · PMID 41762026 · Full text
BackgroundHealth inequalities affect many respiratory diseases. However, little is known about the extent or impact amongst patients treated with home non-invasive ventilation (NIV). This study explored health inequaliti...
BackgroundHealth inequalities affect many respiratory diseases. However, little is known about the extent or impact amongst patients treated with home non-invasive ventilation (NIV). This study explored health inequalities faced by these patients and associations with respiratory healthcare burden.MethodsA retrospective cohort study was conducted on patients actively receiving home-NIV treatment. Data on patient demographics, hospital healthcare burden and NIV adherence was collected between 4 October 2021 to 4 October 2023, and their relationships were evaluated.Results187 patients met the inclusion criteria. Total hospital bed days was higher in females than in males, (11.7 ± 27.0 days vs 5.2 ± 12.5 days, = 0.039), and increasing age was positively associated with higher number of respiratory-related hospital admissions (r = 0.146, = 0.048). There was a weak correlation between deprivation rank and number of NIV care appointments missed (r = -0.163, = 0.031). A higher BMI (>40 kg/m) was associated with lower daily home-NIV use (68.7% ± 4.9% vs 83.0% ± 3.1% nights NIV used, = 0.012).ConclusionPatients with higher BMI had lower NIV adherence, females required more hospital bed days, older patients had more hospital admissions, and more deprived patients missed more hospital appointments.
Implementation of the treatable traits approach in a regional clinic: Improving health outcomes in adults with bronchiectasis.
Krieg KE, Lee AL, Dwyer TJ … +1 more , McKeough ZJ
Chron Respir Dis · 2026 · PMID 41612738 · Full text
ObjectivesTreatable traits are identifiable and treatable features of disease. The primary objective was to evaluate whether a bronchiectasis clinic in a regional setting, implementing a treatable traits approach, would...
ObjectivesTreatable traits are identifiable and treatable features of disease. The primary objective was to evaluate whether a bronchiectasis clinic in a regional setting, implementing a treatable traits approach, would lead to improvements in quality of life. Secondary objectives were to evaluate clinic implementation outcomes, annual exacerbations and hospitalisation.MethodsAn implementation study. Adults with bronchiectasis attending an outpatient clinic in Rockhampton, Australia between 2021 and 2023 were recruited. Clinical care was implemented by a physiotherapist and nurses according to traits identified. Quality of life (QoL-Bronchiectasis respiratory symptom score (QoL-B rs), Leicester Cough Questionnaire (LCQ) total score) was evaluated at baseline, three and 12-months from first attendance. Implementation outcomes were determined by clinic appointment uptake and attendance and pulmonary rehabilitation uptake and completion at 12-months. Exacerbation frequency and hospitalisation for the 12-months before and after enrolment were compared.Results50 participants were recruited [mean (SD) age 71 (12) years; Bronchiectasis Severity Index (%) mild (22) moderate (44) severe (34)]. There was a significant improvement in QoL at three and 12-months from baseline (mean difference, 95% CI) [3 months: QoL-B rs 9.2 (3.2-15.2), LCQ 1.7 (0.6-2.8); 12-months: QoL-B rs 10.1 (3.9-16.3), LCQ 1.8 (0.8-2.8)]. Clinic uptake (91%), attendance (97%) and pulmonary rehabilitation uptake (74%) and completion (84%) were high. Exacerbation frequency [median (IQR) 1.0 (3.0) to 0.0 (1.0), p = 0.007], and hospitalisation decreased (18% vs 0%, p = 0.005).DiscussionA treatable traits approach improved quality of life, was feasible, including the achievement of high pulmonary rehabilitation uptake and completion, and reduced exacerbation frequency and hospitalisation.
Does care managers' initial professional background affect the outcomes of pulmonary rehabilitation? A retrospective cohort study of 2450 individuals with chronic respiratory diseases.
Gephine S, Le Rouzic O, Cailliau E … +2 more , Chenivesse C, Grosbois JM
Chron Respir Dis · 2026 · PMID 41546859 · Full text
ObjectiveThis retrospective study in individuals with chronic respiratory diseases (CRDs) compared changes in quality of life, anxiety and depressive symptoms, and exercise capacity after a home pulmonary rehabilitation...
ObjectiveThis retrospective study in individuals with chronic respiratory diseases (CRDs) compared changes in quality of life, anxiety and depressive symptoms, and exercise capacity after a home pulmonary rehabilitation (PR) programme, based on the care manager's professional background.MethodsPR team was composed of nurses (Gr1, n = 989 patients), physiotherapists (Gr2, n = 466), one dietician and one sociomedical beautician (Gr3, n = 794) and one respiratory physician (Gr4, n = 201) who supervised one home session per week during 8 weeks. Quality of life, anxiety and depressive symptoms, dyspnea and exercise capacity were assessed at the beginning and end of PR, and at 12 months after the end of PR.Results2450 participants were included (females: 41.6%, age: 64.1 ± 13.0 years, FEV: 50.7 ± 25.2% of predicted, people with COPD: 51%, with ILD: 23%, with asthma: 10%). Gr 1, Gr 3 and Gr 4 improved all the assessments at short- and long-term (p < 0.01). Improvement in the Visual Simplified Respiratory Questionnaire in Gr2 was not maintained at long-term. According to the linear mixed models, changes over time were not statistically different between groups.ConclusionA personalised PR programme delivered by one care manager, led to similar short-term benefits regardless of the care manager's initial professional background.
Lung health in the Terai region of Nepal.
Hamrouni M, Sharma SK, Kurmi OP … +8 more , Gautam P, Lohani S, Gautam U, Perone SA, Heller O, Hall IP, McKeever TM, Bolton CE
Chron Respir Dis · 2026 · PMID 41543524 · Full text
BackgroundChronic respiratory disease burden in Nepal is high, although data from the Terai (lowlands) is limited.MethodsThrough a community outreach programme in Mechinagar, 3398 adults (mean age 49.6 years, 59% female)...
BackgroundChronic respiratory disease burden in Nepal is high, although data from the Terai (lowlands) is limited.MethodsThrough a community outreach programme in Mechinagar, 3398 adults (mean age 49.6 years, 59% female) were recruited to complete spirometry and questionnaires to determine prevalences of airflow obstruction, breathlessness (MRC dyspnoea score ≥3) and self-reported chronic lung disease. Multivariate logistic regression examined associated demographic and lifestyle factors.ResultsPrevalences of airflow obstruction (15%) and breathlessness (13%) exceeded self-reported chronic lung disease (8%). Age (odds ratio = 1.06, 95% confidence interval = 1.05-1.07), body mass index (BMI) per 1 kg/m (0.90, 0.88-0.93), physical inactivity (1.95, 1.07-3.84) and no formal education (1.46, 1.14-1.88) were associated with airflow obstruction. Smoking was only associated with airflow obstruction in females (1.90, 1.22-2.94) and adults ≥40 years (1.40, 1.05-1.86). Age (1.04, 1.03-1.05), airflow obstruction (2.43, 1.85-3.18), and male sex (0.63, 0.49-0.80) were associated with breathlessness. Only in females was breathlessness associated with BMI (1.08, 1.05-1.12) and mixed biomass use (2.65, 1.39-4.85). In men, labour/farming/agriculture work (3.30, 1.12-14.20) or unemployment (4.39, 1.43-19.30) was associated with breathlessness.ConclusionThere is likely underdiagnosis of chronic lung disease in the Terai. Addressing smoking, educational disparities, physical inactivity and environmental pollutant exposure are public health priorities to improve respiratory health in the region.
Forced oscillometry technique in the assessment of adults with cystic fibrosis treated for a pulmonary exacerbation, a pilot feasibility study.
Nolan J, Bingham J, Cobb R … +5 more , Hall K, Onn P, Hay K, Wood M, Reid DW
Chron Respir Dis · 2026 · PMID 41486699 · Full text
IntroductionEffective management of pulmonary exacerbations (PEx) in cystic fibrosis (CF) is essential to minimise lung damage and reduce morbidity and mortality. Spirometry, the standard tool for lung function assessmen...
IntroductionEffective management of pulmonary exacerbations (PEx) in cystic fibrosis (CF) is essential to minimise lung damage and reduce morbidity and mortality. Spirometry, the standard tool for lung function assessment in adult people with CF (pwCF), has limitations. Forced Oscillometry Technique (FOT) is an effort-independent method that assesses small airways disease and has been validated in other respiratory conditions. This study evaluated the feasibility and acceptability of implementing FOT during treatment for PEx in adult pwCF.MethodsTwelve adult pwCF underwent FOT and spirometry at the start and end of PEx treatment, and at clinically convenient intervals. FOT was also measured before and after physiotherapy-directed airway clearance. A questionnaire assessed patient satisfaction with FOT.ResultsAll patients had spirometry below baseline at PEx onset and small airways dysfunction on FOT. Treatment was associated with improvements in median FEV1pp (5.1%, = 0.050) and X5 (0.2 cm HO/L/s, = 0.023), with a significant association between FEV1pp and X5 ( = 0.004). There was no significant FOT change after airway clearance. Patients rated FOT more favourably than spirometry.DiscussionFOT is feasible, well-tolerated, and may complement spirometry in assessing adult pwCF during PEx. Further studies are warranted.
Clinical implications of frailty in hospitalized patients with pulmonary arterial hypertension.
Lokhandwala A, Salman Al-Timimi A, Da Silva T … +8 more , Nourouzpour S, Man HSJ, Perrot M, Wentlandt K, Sharif N, Singer LG, Granton J, Rozenberg D
Chron Respir Dis · 2025 · PMID 41437837 · Full text
ObjectivesFrailty is associated with increased morbidity and mortality in chronic lung disease, but its prognosis has not been evaluated in pulmonary arterial hypertension (PAH). This study aimed to assess: (1) impact of...
ObjectivesFrailty is associated with increased morbidity and mortality in chronic lung disease, but its prognosis has not been evaluated in pulmonary arterial hypertension (PAH). This study aimed to assess: (1) impact of frailty on hospital length of stay (LOS) and health-care utilization in PAH; (2) association of frailty with 1-year post-discharge outcomes.MethodsRetrospective, single-centered cohort study of consecutive PAH patients admitted non-electively (January 2009-December 2018), predominantly for right heart failure (57%). Frailty was defined as ≥ 0.25 using a cumulative deficits frailty index. Disease characteristics, hospital factors, and mortality were compared using univariate analysis and multivariable regression, adjusting for age and sex.Results44/96 (46%) PAH patients were frail. Frailty was associated with older age, greater comorbidities, and lower six-minute walk distance pre-admission ( < 0.05). Frail patients had a longer hospital LOS (4 days 95% (0.4-6.3), = 0.04) and were more likely to receive social work consultation (36% vs 13%, = 0.01), independent of age and sex. There were no adjusted differences (frail vs non-frail) in hospital mortality (OR:1.01 95% (0.28-3.72) or 12-months mortality post-discharge (HR:1.26 95% (0.48-3.29).ConclusionFrailty was associated with greater hospital LOS and interdisciplinary support, but not 1-year mortality. Future studies should explore whether alternative frailty models may be more informative of longer-term PAH outcomes.
Connective tissue disease-associated interstitial lung disease risk of readmission and all-cause mortality: Interpretable machine learning approach.
Chen B, Hu X, Shi X … +1 more , Wang B
Chron Respir Dis · 2025 · PMID 41424083 · Full text
ObjectiveConnective tissue disease (CTD) encompasses a group of autoimmune disorders, with interstitial lung disease (ILD) being the most common form of pulmonary involvement. The primary focus of this study was to emplo...
ObjectiveConnective tissue disease (CTD) encompasses a group of autoimmune disorders, with interstitial lung disease (ILD) being the most common form of pulmonary involvement. The primary focus of this study was to employ machine learning for the identification of blood-based biomarkers in individuals afflicted with CTD-ILD. Additionally, the study aimed to assess the potential association of these biomarkers with the likelihood of hospital readmissions and all-cause mortality within a 1-year period among CTD-ILD patients.MethodsA total of 210 patients were included in the study, with 147 patients allocated to the training set and 63 patients assigned to the test set. Univariate logistic regression, LASSO regression, and multivariable logistic regression analyses were executed to discern the risk factors associated with readmission within 1 year among CTD-ILD. Logistic regression, support vector machine, and XGBoost were utilized to build the model. The global and local interpretation of the model was conducted using SHAP. The efficacy of model was evaluated using the ROC curve and DCA. Furthermore, the predictive values of inflammatory indicators were compared for their ability to forecast all-cause mortality in CTD-ILD patients.ResultsLow albumin levels, high CA125, and CYFRA 21-1 were identified as significant factors associated with patient readmissions. The XGBoost model demonstrated the highest efficacy in both the training and test sets, achieving an AUC of 0.857 (95% CI 0.832-0.879) and 0.788 (95% CI 0.706-0.833), respectively. SHAP analysis indicated that low albumin had the most significant impact on the model outcomes. Among the 1-year all-cause deaths of CTD-ILD patients, the neutrophil-to-lymphocyte ratio (NLR) was the most potent predictor in univariate analysis. A model combining albumin, CA125, and CYFRA 21-1 with NLR was constructed, achieving an AUC of 0.944 (95% CI 0.915-0.964).ConclusionElevated levels of CA125, CYFRA 21-1, and NLR, along with lower albumin levels, were predictive of a poor prognosis in CTD-ILD patients.
Association between skeletal muscle index and lung function in populations with different characteristics.
Xia XX, Xue XX, Xiong L … +4 more , Chen YJ, Chen H, He F, Li Q
Chron Respir Dis · 2025 · PMID 41325751 · Full text
IntroductionCurrent research mainly examines the link between sarcopenia and obstructive spirometry, with limited studies on preserved ratio impaired lung function (PRISm). This study aims to investigate the association...
IntroductionCurrent research mainly examines the link between sarcopenia and obstructive spirometry, with limited studies on preserved ratio impaired lung function (PRISm). This study aims to investigate the association between skeletal muscle index (SMI) and lung function indicators in populations with different characteristics, with particular emphasis on the PRISm population.MethodsData were utilized from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 cycle. The participants were categorized into three groups: obstructive spirometry, PRISm, and normal spirometry. The SMI was calculated by dividing appendicular skeletal muscle mass by body mass index. Multiple linear regression analysis was employed to explore the relationship between the SMI and lung function indicators, including forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).ResultsAmong the 2513 participants aged 20-59 years, 2096 had normal spirometry, 186 were in the obstructive spirometry group, and 231 were in the PRISm group. The SMI was significantly associated with lung function indicators after adujustment: in the obstructive spirometry group, per 0.1 unit increase in SMI was linked to an increase in FEV1 of 0.214 L (95% CI: 0.115-0.313, < 0.001) and in FVC of 0.339 L (95% CI: 0.213-0.465, < 0.001); in the PRISm group, per 0.1 unit increase in SMI was associated with an increase in FEV1 of 0.184 L (95% CI: 0.149-0.219, < 0.001) and in FVC of 0.222 L (95% CI: 0.169-0.274, < 0.001); and in the normal spirometry group, per 0.1 unit increase in SMI was linked to an increase in FEV1 of 0.240 L (95% CI: 0.222-0.257, < 0.001) and in FVC of 0.316 L (95% CI: 0.294-0.338, < 0.001).ConclusionOur study newly identifies a significant positive association between SMI and lung function in the PRISm group, a relationship also consistently observed in obstructive and normal spirometry groups.
Eccentric cycling for chronic respiratory disease: Does helmet ventilation add value? A randomized controlled trial.
Chao KY, Liu WL, Hsu HW … +3 more , Chen HC, Lim AY, Wang JS
Chron Respir Dis · 2025 · PMID 41290215 · Full text
BackgroundChronic respiratory diseases frequently cause a decrease in physical activity and lower exercise tolerance. Eccentric Cycling Training (ECT) offers a potential rehabilitation strategy. However, its effectivenes...
BackgroundChronic respiratory diseases frequently cause a decrease in physical activity and lower exercise tolerance. Eccentric Cycling Training (ECT) offers a potential rehabilitation strategy. However, its effectiveness when combined with Helmet Ventilation (HV) is not fully established.MethodsThis nonblinded randomized controlled trial (RCT) investigated the effects of ECT with or without HV in individuals with chronic respiratory diseases. Participants were randomly assigned to the ECT, ECT-HV, or control group and underwent graded exercise testing. The ECT sessions spanned 9 weeks with gradually increasing intensity. The primary outcome was peak oxygen consumption (VO). Secondary outcomes included functional tests and symptom scores.ResultsForty-four patients with chronic respiratory diseases were enrolled and divided among the ECT (n = 13), ECT-HV (n = 15), and control (n = 13) groups. After 9 weeks, significant improvements in the 6-min walk test (6MWT) distance, energy expenditure index during the 6MWT, and timed up and go test were observed in both the ECT and ECT-HV groups compared to the control group. Reductions in initially high Borg leg fatigue were noted over time in these groups. VO at follow-up was 17.6 ± 2.9 ml/min/kg in the control group, 17.2 ± 4.5 ml/min/kg in the ECT group, and 18.2 ± 3.9 ml/min/kg in the ECT-HV group, with no significant differences among groups. No significant differences in achieving the targeted exercise intensity were found between the ECT and ECT-HV groups.ConclusionsOver a 9-week period, eccentric cycling training improved functional capacity and mobility in patients with chronic respiratory diseases, although no significant changes were observed in peak oxygen consumption or overall cardiopulmonary fitness.
Associations of the geriatric nutritional risk index and simplified geriatric nutritional risk index with chronic obstructive pulmonary disease.
Huang Y, Xu R, Chen X … +10 more , Chen S, Dai Z, Li X, Yu Y, Ye Z, Chen X, Liu C, Yu B, Xu Y, Zhang X
Chron Respir Dis · 2025 · PMID 41255303 · Full text
PurposeThis study aimed to investigate the associations of the Geriatric Nutritional Risk Index (GNRI) and the simplified Geriatric Nutritional Risk Index (sGNRI) with Chronic Obstructive Pulmonary Disease (COPD).Methods...
PurposeThis study aimed to investigate the associations of the Geriatric Nutritional Risk Index (GNRI) and the simplified Geriatric Nutritional Risk Index (sGNRI) with Chronic Obstructive Pulmonary Disease (COPD).MethodsWe assessed 161 patients with COPD and 947 healthy controls. The sGNRI was derived using the formula: serum albumin (g/dL) + 0.1 × body mass index (BMI, kg/m). Primary outcomes included the BODE (body mass index, airflow obstruction, dyspnea, exercise capacity) index and hospital length of stay (LOS). The secondary outcome was the prevalence of COPD.ResultsMalnourished patients (GNRI <95.40 or sGNRI <5.89) exhibited lower BMI and albumin levels, as well as worse pulmonary function (all < 0.05). GNRI (Odds Ratio [OR] = 0.945, 95% Confidence Interval [CI]: 0.903-0.989, = 0.015) and sGNRI (OR = 0.413, 95% CI: 0.191-0.890, = 0.024) were significantly associated with the severity of COPD in a multivariable-adjusted model. Subgroup analysis revealed stronger predictive performance of GNRI and sGNRI among males, non-hypertensive patients, and smokers (for sGNRI).ConclusionsCompared with GNRI, sGNRI may serve as a more practical tool for identifying malnutrition-related risk among patients with COPD.
Assessment and management of frailty during pulmonary rehabilitation: An international survey of Australian and New Zealand clinicians.
Alzubaidi AL, Soh S, Wuyts M … +3 more , Munro P, Hill KD, Osadnik CR
Chron Respir Dis · 2025 · PMID 41237409 · Full text
BackgroundFrailty is common among patients referred to pulmonary rehabilitation (PR) programs. While it is considered an independent predictor of program non-completion, people with frailty respond positively to PR. Clin...
BackgroundFrailty is common among patients referred to pulmonary rehabilitation (PR) programs. While it is considered an independent predictor of program non-completion, people with frailty respond positively to PR. Clinicians' perspectives on assessing and managing frailty in PR has not been established. This study aimed to identify clinicians' current practices, perceptions, and opinions on assessing and managing frailty in people who attend PR in Australia and New Zealand.MethodsAn international online survey targeting healthcare professionals in Australia and New Zealand involved in PR programs using a combination of multiple-response closed-ended and open-ended questions. This survey study was reported in accordance with the Consensus-Based Checklist for Reporting of Survey Studies (CROSS).ResultsOf 103 responses, 89 healthcare professionals completed the survey (92.6% completion rate). Nineteen percent routinely assessed frailty, mostly using Short Physical Performance Battery (SPPB). Respondents reported the main considerations for choice of frailty assessment tools were ease of use and cost. The most common frailty indicators identified by respondents included falls history, low body weight, slow or aided gait, and muscle weakness. Seventy-nine percent believed PR to be appropriate to manage frailty in this population, while 94% desired additional resources in future guidelines. Suggestions to improve PR to better manage frailty included reshaping rehabilitation program content, and providing specific patient education. Future desired research priorities included improvements to frailty assessment tools, frailty-specific guidelines and workforce training.ConclusionThis study explores PR practices among clinicians in Australia and New Zealand, showing variability in frailty assessment and management. It provides a foundation for evaluating key aspects of PR models that can be tailored to these clients' needs and limitations.
The order of completing MDP and D12 does not affect the breathlessness responses: A randomised controlled trial.
Wemar I, Sandberg J, Olsson M … +2 more , Sundh J, Ekström M
Chron Respir Dis · 2025 · PMID 41166646 · Full text
BackgroundBreathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) a...
BackgroundBreathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.MethodsThis was a randomised controlled trial embedded within a longitudinal clinical study. Outpatients with cardiorespiratory disease were randomly assigned to either first complete the MDP or the D12. Primary outcome was mean difference in D12 total score between groups, secondary outcome was mean difference in D12 and MDP subdomain scores. Both outcomes were compared to the minimal clinically important difference (MCID) for each scale.ResultsAll 182 participants from the longitudinal study were included. 93 were randomized to complete MDP first and 89 to D12 first. Characteristics such as age, sex, main cause of breathlessness and smoking status were similar between groups. The mean difference for D12 total score (MCID = 2.8) was -1.5 (-4.2 to 1.3, = 0.26) between groups. Mean differences between groups in subdomain scores were also below the corresponding MCID.ConclusionThe order of completion of MDP and D12 did not impact the scores significantly, but the study lacked power to find smaller yet clinically significant differences. The study supports that the most practical order of completing the instruments can be used in future research and in clinical settings.
Risk factors for pneumothorax in patients with interstitial lung disease undergoing transbronchial lung cryobiopsy, a research letter.
Landers S, Morrow J, McCarthy J … +1 more , Henry MT
Chron Respir Dis · 2025 · PMID 41117215 · Full text
BackgroundPneumothorax is a common and important complication of transbronchial lung cryobiopsy (TBLC) in patients with interstitial lung disease (ILD), however little is known about what predisposes patients to pneumoth...
BackgroundPneumothorax is a common and important complication of transbronchial lung cryobiopsy (TBLC) in patients with interstitial lung disease (ILD), however little is known about what predisposes patients to pneumothorax during TBLC.MethodsWe reviewed the pre-TBLC ILD work-up of 76 patients who underwent TBLC in our tertiary ILD referral center from 2017 to 2023. We assessed factors including pulmonary function tests, bronchoalveolar lavage (BAL), blood tests, and imaging and to see if any of them caused an increased risk of iatrogenic pneumothorax.Results19 patients suffered a pneumothorax (25%). Neutrophilia on BAL (37.9% pneumothorax when present vs 12.8% when not present, = 0.046) and the presence of ground glass opacification on high resolution CT-Thorax (38.2% vs 12.5%, = 0.014) increased the risk of pneumothorax during TBLC. Other factors such as the presence of pleura in the biopsy sample (47.1% vs 17.2%, = 0.021), as well as taking 3 or more biopsies (35.7% vs 11.8%, = 0.019) were also significant predictors of pneumothorax.ConclusionsMarkers of acute inflammation as well as increased number of biopsies taken in a procedure lead to increased risk of pneumothorax. This may lead to changes in planning, patient selection and timing of TBLC procedures in ILD patients.
Symptomatic improvement in patients with excessive dynamic airway collapse (EDAC) following initiation of positive airway pressure therapy.
Shah NM, Grovestock M, Jadeja K … +9 more , D'Cruz R, Marino P, Ramsay M, Srivastava S, Steier J, Hart N, Suh ES, Murphy PB, Kaltsakas G
Chron Respir Dis · 2025 · PMID 41025700 · Full text
Excessive dynamic airway collapse (EDAC) is characterized by abnormal airway collapse during expiration, leading to symptoms such as breathlessness, cough, and reduced quality of life. Treatment options remain limited, a...
Excessive dynamic airway collapse (EDAC) is characterized by abnormal airway collapse during expiration, leading to symptoms such as breathlessness, cough, and reduced quality of life. Treatment options remain limited, and evidence-based guidelines are lacking. This prospective cohort study evaluated the impact of positive airway pressure (PAP) therapy on symptom burden in 23 patients with EDAC referred to a tertiary ventilation centre. Diagnosis was confirmed by computed tomography and/or bronchoscopy. Patients received nocturnal and ambulatory PAP, with symptom ratings and quality of life assessed at baseline and after three months. PAP therapy produced rapid and sustained improvements in breathlessness, orthopnoea, cough frequency, sleep quality, and quality of life, with significant differences in all domains ( < 0.01). Adherence to nocturnal PAP was high. These findings suggest that PAP therapy is an effective symptomatic intervention in EDAC and support consideration of EDAC as an indication for PAP therapy in future clinical guidelines.
Patients with chronic obstructive pulmonary disease and the use of complementary and alternative medicine: The role of health literacy in Türkiye.
Ersözlü M, Akıncı Aydınlı E, Selçuk E … +1 more , Şen E
Chron Respir Dis · 2025 · PMID 41022403 · Full text
BackgroundChronic obstructive pulmonary disease (COPD) is a heterogeneous and chronic condition characterized by irreversible airflow obstruction. Health literacy may influence the use of complementary and alternative me...
BackgroundChronic obstructive pulmonary disease (COPD) is a heterogeneous and chronic condition characterized by irreversible airflow obstruction. Health literacy may influence the use of complementary and alternative medicine (CAM). This study aims to investigate the role of health literacy in the use of CAM among COPD patients.MethodsThis cross-sectional study was conducted at Ankara University School of Medicine, Department of Chest Diseases, involving patients with COPD between August 2024 and June 2025. Clinical COPD Questionnaire (CCQ) and Health Literacy Scale-Short Form (HLS-SF) were used to assess disease severity and health literacy, respectively.ResultsAmong 190 patients, inadequate and limited health literacy was more common among CAM users compared to non-users (n = 54/89, 61% vs n = 37/101, 37%, respectively, = 0.007). CAM users were also more likely to have insufficient social support (n = 24/89, 25%, = 0.047), cough (n = 79/89, 89%, = 0.049), history of ICU admission (n = 19/89, 21%, = 0.02), use of long-term oxygen therapy and noninvasive ventilation (n = 50/89, 56% = <0.001; n = 26/89, 30%, = <0.001, respectively), had higher rates of GOLD E classification (47/89, 55%, = <0.001), and had higher median CCQ total scores as 2.78 [Interquantiler Range (IQR): 1.4-4.1, p = 0.002]. Inadequate and limited health literacy was significant predictors of CAM use (OR: 3.78; 95% CI: 1.25-11.4, = 0.018; OR: 6.78, 95% CI: 1.63-28.0, = 0.008, respectively), as well as GOLD E classification (OR: 2.71, 95% CI: 1.14-6.45, = 0.024) and insufficient social support (OR: 2.56, 95% CI: 1.00-6.50, = 0.048) after adjusting for age, sex, education, and comorbidities.DiscussionThis study revealed the association between COPD symptom severity and frequent exacerbation, insufficient social support, along with lower health literacy and the use of CAM.
Transcranial direct current stimulation's effect on exercise capacity, respiratory muscle strength, and physical performance in patients with chronic obstructive pulmonary disease: Randomized controlled trial.
Sawasdee C, Auvichayapat P, Boonsawat W … +4 more , Chumpangern W, Thasomboon M, Hanwaree N, Tunkamnerdthai O
Chron Respir Dis · 2025 · PMID 40998469 · Full text
BackgroundChronic obstructive pulmonary disease (COPD) is associated with alterations in brain function that contribute to reduced respiratory and skeletal muscle strength, ultimately limiting exercise capacity. Transcra...
BackgroundChronic obstructive pulmonary disease (COPD) is associated with alterations in brain function that contribute to reduced respiratory and skeletal muscle strength, ultimately limiting exercise capacity. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has demonstrated efficacy in enhancing lower extremity function in healthy older adults.ObjectiveTo evaluate the effects of a single session of anodal tDCS on exercise capacity, respiratory muscle strength, and physical performance in individuals with COPD.MethodsIn a randomized, double-blind, sham-controlled trial, 26 participants with COPD underwent baseline assessments of exercise capacity (Six-Minute Walk Distance, 6MWD), respiratory muscle strength (Maximum Inspiratory Pressure, MIP), and physical performance (4-m Gait Speed, 4MGS). Participants then received either active or sham tDCS, followed by reassessment 1 day post-intervention.ResultsCompared to sham, the active tDCS group showed significant improvements in physical performance, including increases of 46 ± 11.45 m in 6MWD ( < 0.001), 12.54 ± 4.52 cm, HO in MIP ( < 0.01), and 0.24 ± 0.08 m/s in 4MGS ( < 0.05).ConclusionA single session of anodal tDCS may enhance exercise capacity, inspiratory muscle strength, and gait speed in patients with COPD, suggesting its potential as a supportive intervention in pulmonary rehabilitation.
Telomere biology disorder associated lung disease- case report of a gene variant as the cause of pleuroparenchymal fibroelastosis.
Pott J, Höing AS, Volk A … +6 more , Well L, Beier F, Lebrecht D, Harbaum L, Klose H, Oqueka T
Chron Respir Dis · 2025 · PMID 40926757 · Full text
Case presentationDescription of a patient with a progressive destructive lung disease resembling pleuroparenchymal fibroelastosis, liver cirrhosis and bone marrow changes. Genetic workup identified a rare heterozygous co...
Case presentationDescription of a patient with a progressive destructive lung disease resembling pleuroparenchymal fibroelastosis, liver cirrhosis and bone marrow changes. Genetic workup identified a rare heterozygous coding variant in the (telomerase reverse transcriptase) gene c.472 C>T; p.(Leu158Phe) and telomere length testing revealed significant telomere shortening, supporting the diagnosis of telomere biology disorder (TBD).DiscussionTBD is an underrecognized cause of interstitial lung disease (ILD). It is a heterogeneous disease that can affect different organs, including lungs, liver and bone marrow. Genetic testing in ILD is crucial for early diagnosis, risk assessment, and family screening. Identifying this variant enables targeted genetic testing for relatives, allowing preventive measures and lifestyle modifications.
Feasibility and acceptability of home-based pulmonary rehabilitation for individuals with idiopathic pulmonary fibrosis in Delhi, India.
Hanif H, Ahmed O, Manifield JR … +8 more , Shibli M, Barradell A, Ahmed Z, Malcolm D, Barton A, Talwar D, Orme MW, Singh SJ
Chron Respir Dis · 2025 · PMID 40899705 · Full text
ObjectivesTo determine the feasibility and acceptability of home-based pulmonary rehabilitation (HBPR) for individuals with idiopathic pulmonary fibrosis (IPF).MethodsIn this single-arm feasibility trial, individuals wit...
ObjectivesTo determine the feasibility and acceptability of home-based pulmonary rehabilitation (HBPR) for individuals with idiopathic pulmonary fibrosis (IPF).MethodsIn this single-arm feasibility trial, individuals with IPF were recruited from Delhi, India, to a 6-weeks HBPR programme using a paper-based manual. Primary outcomes were feasibility (classified by ≥60% of eligible patients recruited and ≥70% of recruited patients completing the follow-up assessment) and intervention acceptability (semi-structured interviews).ResultsOut of 42 screened, 36 individuals were eligible (86% of screened), and 30 were recruited (83% of eligible, 71% of screened; 60 ± 13 years, 53% female), with 25 completing their follow-up assessment (83% of recruited). HBPR was generally well-accepted, with qualitative themes including: 'facilitators and barriers to HBPR' (family support and flexibility of home environment were facilitators whereas lack of supervision and inability to follow a routine were barriers), 'perceived changes from taking part in HBPR' (improved exercise capacity, breathlessness, and independency), and 'how to improve HBPR in the future' (translating the manual into various languages, and incorporating into a more hybrid approach).ConclusionHBPR using a paper-based manual was feasible and acceptable, potentially suitable for improving the uptake and completion of PR for individuals with IPF in Delhi, India.
Cutoff points for sedentary behavior and their capacity to predict mortality in individuals with COPD: A 12- year follow-up study.
Santin L, Silva H, Tofoli TM … +3 more , Medeiros L, Furlanetto KC, Pitta F
Chron Respir Dis · 2025 · PMID 40847832 · Full text
ObjectiveThis study aimed to identify the usefulness and compare three cutoff points of sedentary behavior (i.e., >8.5 h/day in sedentary time [ST], >70% of the awake time spent in ST, and <4300 steps/day) as predictors...
ObjectiveThis study aimed to identify the usefulness and compare three cutoff points of sedentary behavior (i.e., >8.5 h/day in sedentary time [ST], >70% of the awake time spent in ST, and <4300 steps/day) as predictors of all-cause mortality over a 12-years follow-up period in individuals with stable COPD.MethodsBaseline-only data from 92 individuals with COPD assessed for admission to pulmonary rehabilitation were analyzed.ResultsCox multivariate regression models identified the cutoff point of ST >8.5 h/day as an independent predictor of mortality after adjusting for confounders (hazard ratio 1.23, 95% CI 1.021 - 1.589, P = 0.02). The other two cutoffs were not significant.ConclusionAmong different cutoffs indicating sedentary behavior, ST >8.5 h/day was identified as an independent indicator of higher mortality risk in a 12-years follow-up period in individuals with stable COPD, indicating a 23% higher mortality risk in comparison to those who present ST <8.5 h/day.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe