Brinkman MC, Mehta T, Pennell ML
… +15 more, Angeles D, Kahassai S, Wu CM, Curran H, Keller-Hamilton B, Klein EG, Roberts ME, Nini P, Adetona O, Patterson JG, Mays D, Mandarano L, Jankowski E, Thomas A, Ferketich AK
Addict Behav
· 2026 Jan · PMID 41124756
·
Full text
INTRODUCTION: Waterpipe (WP) smoking is commonly misperceived as less harmful than cigarette smoking. Graphic warning labels (GWLs) may correct misperceptions and reduce WP smoking. We determined the impact of a GWL plac...INTRODUCTION: Waterpipe (WP) smoking is commonly misperceived as less harmful than cigarette smoking. Graphic warning labels (GWLs) may correct misperceptions and reduce WP smoking. We determined the impact of a GWL placed on a WP on short-term smoking behaviors and other outcomes among young adults who smoke WP. METHODS: Young adults, ages 21-35 years, who smoke WP were randomized to a control (Visit1 = Blank, Visit2 = Blank label) or experimental (Visit1 = Blank, Visit2 = GWL, Visit3 = GWL) group. Participants smoked a research-grade WP in the lab ad lib to satiation, for a maximum of 60 min, for up to 3 visits, each separated by a week. Puffing topography was measured continuously throughout the session. Exhaled CO, harm perceptions, and subjective effects were measured before and after each smoking session. Outcome data were analyzed using linear mixed models to account for incomplete, repeated measurements. RESULTS: There were no significant differences in study outcomes within and between assigned groups, except for the following from Visit1 and Visit3 in the GWL group: 1) a reduction in puff volume (p = 0.048); 2) a reduction in good taste and calmness (p = 0.027 and 0.007, respectively); and 3) a reduction in being confused after smoking (p = 0.042). CONCLUSIONS: GWLs on WPs may not be the sole effective tool for reducing the harm from WP smoking. More research is needed to determine if WP interventions aimed at improving population health should include a wider variety of tools, such as education, cessation services, and product standards that limit the appealing aspects of WP tobacco.
BACKGROUND: Problematic social media use (PSMU) represents a growing concern among adolescents globally. While existing variable-centered research has provided valuable insights into PSMU determinants, person-centered ap...BACKGROUND: Problematic social media use (PSMU) represents a growing concern among adolescents globally. While existing variable-centered research has provided valuable insights into PSMU determinants, person-centered approaches can offer complementary perspectives by identifying behavioral heterogeneity within populations and examining how social determinants differentially affect distinct subgroups across diverse national contexts. OBJECTIVES: This study aimed to (1) identify distinct PSMU behavioral classes at the individual level, (2) classify countries/regions based on PSMU prevalence patterns, and (3) examine how multilevel social determinants predict class membership. METHODS: Data were from 171,447 adolescents across 41 countries/regions. Multilevel latent class analyses were first conducted on nine dimensions of PSMU to identify distinct classes at individual and national levels. Individual-level measures incorporated social relationship quality, health behaviors, and economic deprivation. National-level indicators included economic development, education, income, inequalities, and cultural values. Multinomial regressions were performed to examine associations between social determinants and PSMU class membership. RESULTS: Three distinct individual-level PSMU classes emerged: Low Problematic Use Class (58.0%), Moderate Problematic Use Class (37.6%), and High Problematic Use Class (4.3%). Countries/regions are clustered into three categories: Low Prevalence Region (31.7%), Moderate Prevalence Region (39.0%), and High Prevalence Region (29.2%). At the individual level, positive social relationships and healthy lifestyles demonstrated protective effects against problematic use, while economic deprivation increased risk. At the national level, educational inequality, secular values, and gender inequality significantly increased the likelihood of countries belonging to the High Prevalence Region. CONCLUSION: Adolescent PSMU manifests heterogeneously across individuals and exhibits geographic variation. This study highlights the necessity of multilevel, differentiated intervention strategies, emphasizing that countries/regions should develop policies aligned with their specific characteristics to foster supportive environments for adolescent digital well-being.
BACKGROUND: The shifting dynamics of cannabis legislation in the U.S. has over half the states legalizing recreational use for adults and others opting for decriminalization. As tobacco use wanes, the surge in cannabis u...BACKGROUND: The shifting dynamics of cannabis legislation in the U.S. has over half the states legalizing recreational use for adults and others opting for decriminalization. As tobacco use wanes, the surge in cannabis use presents a worrisome trend among adults. This study examines cigarette and cannabis use and co-use among U.S. adults from 2015 to 2023, emphasizing key sociodemographic variations. METHODS: Utilizing the National Survey on Drug Use and Health, we explored the prevalence and trends of past 30-day cigarette and cannabis co-use, cannabis-only use, and cigarette-only use among adults 18 and older over three periods: 2015-2019, 2020, and 2021-2023. Analyses were conducted across various sociodemographic factors, and predictors of substance use were identified using multivariable logistic regressions. RESULTS: Cannabis-only use increased from 3.9% to 6.5% in 2015-2019, was 7.1% in 2020, and increased again from 7.9% to 10.6% in 2021-2023. Cigarette-only use decreased from 15.0% to 12.0% in 2015-2019, was 10.3% in 2020, and declined again from 10.8% to 8.8% in 2021-2023. Co-use was relatively stable across the different periods. Among socioeconomically disadvantaged adults (with lower education, income, or lacking insurance), cigarette-only use was most prevalent. In contrast, cannabis-only use predominated among more socioeconomically advantaged groups (college-educated, high-income, and privately insured). CONCLUSION: Cannabis-only use and co-use trends pose public health risks akin to cigarettes, necessitating targeted prevention campaigns. A multi-pronged strategy of public health education, early detection, and effective treatment development is vital to prevent cannabis from becoming the next public health crisis.
In view of recent global trends in alcohol use, it becomes increasingly relevant to characterize health outcomes related to alcohol use. Previous studies that reported associations between alcohol use and brain health ha...In view of recent global trends in alcohol use, it becomes increasingly relevant to characterize health outcomes related to alcohol use. Previous studies that reported associations between alcohol use and brain health have not validated self-reported alcohol intake, considered only a very narrow demographic strata, or a limited subset of potential confounders and cortical regions for the assessment of brain health. This study aimed to analyze several neuroimaging-derived phenotypes and their associations with at-risk alcohol use in the general population. At-risk alcohol use was operationalized as the regular consumption of more than two units of alcohol at least twice a week. Cortical thickness, gray matter volume, and brain age gaps were derived from T1-weighted magnetic resonance imaging and compared between population-based individuals regularly engaging in at-risk alcohol use (n = 123) versus those who don't (n = 403). Self-reported alcohol use was validated across groups by comparing gamma-glutamyltransferase levels. At-risk alcohol use was associated with higher gamma-glutamyltransferase levels and lower regional cortical thickness across all four lobes of the brain. We also observed higher brain age gaps of 1.21 years on average (CI: 0.26 to 2.15, p = 0.013) in individuals engaging in at-risk alcohol use. No associations with subcortical gray matter were detected. At-risk alcohol use was related to poor brain health as indicated by cortical thinning and accelerated brain aging in the general population. The findings underscore the potentially deleterious associations between alcohol use and neuroimaging-derived phenotypes. These findings, and particularly the accelerated brain aging, are increasingly relevant in view of recent global trends in alcohol use.
Craving is widely recognized as a central feature of addiction. Although internet gaming disorder is notably prevalent among adolescents, the mechanisms that lead to the development of craving for online gaming are not w...Craving is widely recognized as a central feature of addiction. Although internet gaming disorder is notably prevalent among adolescents, the mechanisms that lead to the development of craving for online gaming are not well understood. This study investigated the mediating role of desire thinking and thought suppression in the link between adolescents' positive and negative metacognitions about online gaming and their craving for it. The study evaluated 991 Chinese adolescents utilizing the Metacognitions about Online Gaming Scale, Desire Thinking Questionnaire, Thought Suppression Inventory, and Craving Assessment Scale. Results showed that desire thinking and thought suppression partially mediated the link between both positive and negative metacognitions and craving, with desire thinking exhibiting a stronger indirect effect than thought suppression. The study indicates that both positive and negative metacognitions are associated with adolescent online gaming craving via similar cognitive pathways, with desire thinking being a significant factor. This study highlights the potential of targeting metacognitive processes in future interventions for internet gaming disorder, emphasizing the need for intervention strategies tailored to address desire thinking.
The directions of the causal relationships between gaming-specific maladaptive cognitions (MCIG) and internet gaming disorder (IGD) are implicative but unclear, with few longitudinal studies in this regard. Bidirectional...The directions of the causal relationships between gaming-specific maladaptive cognitions (MCIG) and internet gaming disorder (IGD) are implicative but unclear, with few longitudinal studies in this regard. Bidirectional relationships are plausible, as suggested by the Cognitive Behavioral Model of Pathological Internet Use and Cognitive Dissonance Theory. This 12-month two-wave longitudinal study was conducted among 1857 junior middle school students in two Chinese cities to investigate the reciprocal relationships between three domains of MCIG (perceived overevaluation of rewards, perceived urges, and perceived reluctance to stop playing) and IGD. The prevalence of IGD was 10.0 % at Wave 1 (W1) and 9.6 % at Wave 2 (W2). Cross-lagged panel analysis revealed that IGD at W1 significantly predicted all three domains of MCIG at W2. However, among the three MCIG domains, only perceived urges at W1 significantly predicted IGD at W2. Bidirectional relationships were identified between perceived overvaluation of rewards and perceived reluctance to stop playing. Perceived reluctance to stop playing predicted perceived urges, but the reverse was not true. Relationships between perceived overvaluation of rewards and perceived urges were not statistically significant in either direction. In conclusion, significant bidirectional relationships were observed between one domain of MCIG and IGD, as well as between one pair of MCIG; not all MCIG domains were risk factors of IGD. These findings highlight the importance of targeting specific MCIG to disrupt potential vicious cycles. Caution is warranted when interpreting cross-sectional associations, and future longitudinal studies with additional points are recommended for verification.
OBJECTIVE: We quantify and compare population-level trends in blunt smoking across demographics as well as behavioral and regulatory factors among adults in the US from 2015 to 2022. METHODS: We analyzed eight (8) years...OBJECTIVE: We quantify and compare population-level trends in blunt smoking across demographics as well as behavioral and regulatory factors among adults in the US from 2015 to 2022. METHODS: We analyzed eight (8) years of data from the National Survey of Drug Use and Health (NSDUH). Participants were n = 326,087 adults; a subsample of n = 22,294 current blunt smokers was used to examine daily blunt smoking. We modeled linear trends in lifetime (ever), current (past 30-day), and daily (30/30 days) blunt smoking by: sex, race/ethnicity, age category, income, Major Depressive Episodes, alcohol use, and state-level cannabis regulatory policy. RESULTS: From 2015 to 2022, lifetime blunt smoking increased ∼21.7 % (p < 0.001), current blunt smoking increased ∼34.4 % (p < 0.001), and daily blunt smoking among current users increased ∼24.5 % (p < 0.001). Lifetime blunt smoking increased significantly more among non-Hispanic White (23.7 %) and Hispanic (30.2 %) relative to non-Hispanic Black (8.6 %) adults; similar increases were observed among those older than 18-25 years. Current blunt smoking increased significantly greater among females (63.6 %) relative to males (19.0 %) and among those who did not use alcohol (92.3 %) relative to those who did use alcohol (23.4 %). Daily blunt smoking increased significantly greater among non-Hispanic White (80.4 %) relative to non-Hispanic Black (3.7 %) adults. CONCLUSION: Blunt smoking increased substantially from 2015 to 2022. The greatest increases in blunt smoking were observed among females, older adults, and those who did not use alcohol; groups with historically lower rates of blunt smoking. Future study is needed to understand patterns of blunt initiation, escalation, and use disorder.
BACKGROUND AND AIMS: Craving plays a critical role in the development and maintenance of addiction, including gaming disorder. While affective states are associated with cravings in substance-related use and disorders, t...BACKGROUND AND AIMS: Craving plays a critical role in the development and maintenance of addiction, including gaming disorder. While affective states are associated with cravings in substance-related use and disorders, the relationship between affect and game craving remains understudied. This study employs an ecological momentary assessment (EMA) approach to investigate how momentary positive and negative affect are related to game craving in adolescents, and whether these associations vary by individual differences in gaming disorder risk. METHODS: A total of 317 Hong Kong Chinese adolescents who self-reported as regular gamers completed a pre-EMA survey, followed by a 14-day EMA protocol. Participants reported their momentary positive affect, negative affect, and game craving at four time points daily. RESULTS: At the within-person level, elevated momentary positive and negative affect were significantly associated with increased odds of game craving. However, adolescents at higher risk for gaming disorder showed a reversed pattern, reporting reduced craving when experiencing greater affect intensity than their personal average. DISCUSSION AND CONCLUSIONS: These findings illustrate the complex dynamics between affect and game craving, highlighting the moderating role of an individual's gaming disorder risk. Understanding how affect interacts with game craving in real-word setting may inform targeted interventions for adolescents vulnerable to problematic gaming.
Previous research has shown that subjective and negative solitary experiences, such as loneliness, are associated with increased problematic social media use (PSMU). However, further research is needed to examine the rol...Previous research has shown that subjective and negative solitary experiences, such as loneliness, are associated with increased problematic social media use (PSMU). However, further research is needed to examine the role of other solitary experiences and motivations for solitary behavior in PSMU. Accordingly, the current study investigated the relationships between various solitary experiences (i.e., trait loneliness, perceived isolation, lack of relational connectedness, positive solitude, and frequency of solitary behavior), motivations for solitary behavior (i.e., autonomous and controlled), motives for social media use (i.e., enhancement, coping, conformity, and social), and core and peripheral symptoms of PSMU in young adults. Eight hundred twenty-nine young adults (65 % females), aged 18 to 30 years (M = 23.76, SD = 3.16), completed self-report measures assessing the variables of interest. Psychometric network analysis was performed to estimate regularized partial correlations among variables across the entire sample. Gender differences in network properties were evaluated using the network comparison test. Results showed that controlled motivations for solitary behavior and perceived isolation were indirectly linked to core symptoms of PSMU through conformity motives. Additionally, perceived isolation was also associated with core PSMU symptoms through coping motives. No significant gender differences were found in the network properties. These findings suggest that PSMU might serve as a maladaptive strategy to temporarily compensate for involuntary solitary experiences and to seek relief from perceived isolation.
Although previous studies have suggested that individuals with low self-compassion from dysfunctional familiesare at higher risks of developing online gaming addiction, the distinction between between-person differences...Although previous studies have suggested that individuals with low self-compassion from dysfunctional familiesare at higher risks of developing online gaming addiction, the distinction between between-person differences and within-person effects in these associations has not been fully explored. This longitudinal study examined the reciprocal relations between social support and internet gaming disorder symptoms (IGDs), as well as the potential mediating role of self-compassion, while differentiating between- and within-person effects. A total of 5785 students (48.2 % of female, M = 18.63, SD = 0.88) participated in a large-scale health-related cohort study of college students. The random intercept cross-lagged panel model (RI-CLPM) was used for data analysis. The findings revealed a reciprocal within-person relationship between family support and self-compassion. Self-compassion played a significant longitudinal mediating role in the association between family (but not peer) support and IGDs at the within-person level. These findings emphasize self-compassion as a key psychological mechanism in the relations between family support and IGDs. Future prevention and intervention programs targeted at bolstering family support and cultivating self-compassion may be effective in mitigating the risk of online gaming addiction.
The associations between problematic social media use (PSMU), depression, and social anxiety (SA) remain a topic of debate. Hence, this study investigated the bidirectional longitudinal relationships of PSMU with depress...The associations between problematic social media use (PSMU), depression, and social anxiety (SA) remain a topic of debate. Hence, this study investigated the bidirectional longitudinal relationships of PSMU with depression and SA in a sample of Chinese university students, with an additional emphasis on potential sex differences. A total of 378 students (56.3 % male, 43.7 % female; Mage = 20.49 years, SD = 0.65) completed three waves of survey data. Random Intercept Cross-lagged panel model analysis and multi-group analysis by sex were conducted. At the within-person level, a reciprocal relationship was observed between PSMU and depression over time. Furthermore, SA predicted later increases in PSMU, whereas the reverse associations were not significant. These results highlight the dynamic interplay among emotional symptoms and digital behavior, and underscore the importance of considering both individual differences and temporal fluctuations in future research.
BACKGROUND: Gaming disorder is a new addictive disorder under the ICD-11. Most of recent research focuses on young people and its impact on mental and physical health. However, it can also have negative financial impacts...BACKGROUND: Gaming disorder is a new addictive disorder under the ICD-11. Most of recent research focuses on young people and its impact on mental and physical health. However, it can also have negative financial impacts as in-game microtransaction and esport betting becoming more common, and this impact could be particularly problematic for older people. This study estimates the association between gaming disorder and game-related overspending. METHOD: Data were from the 2022 International Gaming Study (IGS22), a multi-country cross sectional survey of 955 individuals aged 18-94 (M = 46; SD = 16; 45 % Male). We estimated the proportion of participants who reported game-related overspending and modelled its association with ICD-11 Gaming Disorder using logistic regression. RESULT: In general, a much smaller but non-negligible proportion of older people (66 years old + ) reported various type of game-related overspending (4 - 9 %) compared to younger age groups. Individuals who are at risk of gaming disorder were at six to nine times higher odds of reporting various type of gaming-related overspending. CONCLUSION: This study reveals a novel association between gaming disorder and overspending on purchasing games, in-game purchases, and esports betting across various age groups. While young individuals were more likely to report overspending, some older adults were also affected. As the measure reflects self-reported overspending, further research is needed to assess whether this translates into actual financial hardship.
Gambling-related harms significantly impact not only gamblers but also people socially connected to them (affected others or AOs), yet quantifying these impacts has remained challenging. This study developed and validate...Gambling-related harms significantly impact not only gamblers but also people socially connected to them (affected others or AOs), yet quantifying these impacts has remained challenging. This study developed and validated two scales for measuring harm to people due to someone else's gambling - the 10-item and 20-item Gambling Harms Scale for Affected Others (GHS-10-AO and GHS-20-AO) - benchmarked to health utility metrics. Using data from 2,018 Australian adults with close relationships to gamblers, we employed psychometric item selection, propensity weighting, and control for comorbidities to establish evidence for causal links between reported harms and health utility decrements measured by the SF-6D. Emotional, relational, and financial harms were the most prevalent items selected. Both scales demonstrated excellent reliability (α = 0.89 for GHS-10-AO; α = 0.94 for GHS-20-AO) and strong correlations with health utility measures (r = -0.47 to -0.48 with SF-6D). The relationship between harm scores and health utility showed significant non-linearity, with increasing convexity at higher harm levels. These scales provide the first validated instruments for quantifying health impacts to AOs using a common metric comparable to gambler-focused harm measures, enabling population-level assessment of current gambling harm in the adult population; inclusive of gamblers and connected others. The instruments fill a critical gap in gambling harm measurement and offer jurisdictions tools for monitoring progress toward harm minimisation that encompasses impacts on both gamblers and those around them.
Brief mindfulness meditation induction effectively reduces addictive behaviors in clinical populations, yet their impact on non-addicted individuals remains unclear. This study investigated whether brief mindfulness prac...Brief mindfulness meditation induction effectively reduces addictive behaviors in clinical populations, yet their impact on non-addicted individuals remains unclear. This study investigated whether brief mindfulness practice amplifies alcohol enjoyment and consumption in healthy young adults. Across two randomized controlled trials (Study 1:N = 67; Study 2:N = 89), participants with low-risk drinking profiles completed a 16-minute mindfulness induction or a neutral control task, followed by alcohol tasting and behavioral measures. Results revealed that mindfulness significantly enhanced subjective alcohol enjoyment (Study 1:d = 0.45,p = 0.01; Study 2:d = 0.45,p = 0.04) and increased positive affect while reducing negative emotion (d = 0.95-1.20,p < 0.001), but did not alter actual consumption. An Implicit Association Test (IAT) in Study 2 showed no group differences in implicit attitudes toward alcohol versus tea. These findings indicate that brief mindfulness may intensify affective and sensory responses without increasing use-possibly due to a dissociation between reward sensitivity and behavioral impulse. The results align with dual-process theories of mindfulness (e.g., Monitor and Acceptance Theory, Mindfulness-to-Meaning Theory), and highlight the importance of aligning mindfulness practices with motivational and regulatory goals to avoid unintended reinforcement of substance-related pleasure in non-addicted populations.
BACKGROUND: Patients with internet gaming disorder (IGD) suffer from an imbalance of over-integrated and weakly dissociated functional brain networks. Approach bias modification training (ApBMt) has been used to correct...BACKGROUND: Patients with internet gaming disorder (IGD) suffer from an imbalance of over-integrated and weakly dissociated functional brain networks. Approach bias modification training (ApBMt) has been used to correct patients' automatic approach biases to addictive stimuli; however, research exploring changes in brain network topology is limited. METHODS: Seventy subjects were randomly assigned to the approach-avoidance task (AAT) group or the sham-AAT group, and 57 subjects (AAT, 30; sham-AAT, 27) completed the entire procedure, which included pretests, AAT/sham-AAT interventions, and posttests. Behavioral and resting-state fMRI data were collected before and after the tests. This study aimed to investigate the effects of ApBMt on topological changes in resting functional brain networks in patients with IGD and explore the relationship between these network changes and behavioral indicators of addiction severity. RESULTS: Repeated-measures ANOVA of the behavioral data showed that the AAT group had significant score reductions after ApBMt. Imaging data revealed significant decreases in brain network over-integration and increases in segregation of the fronto-parietal network (FPN) and the cingulo-opercular network (CON). Additionally, a positive correlation was found between the post-pre difference in DSM-5 scores and the post-pre difference in nodal efficiency (Ne) in the anterior prefrontal cortex (aPFC). CONCLUSIONS: The findings of this study demonstrate that ApBMt effectively reduces the severity of IGD, along with associated changes in brain network topology, such as enhanced segregation and decreased over-integration. However, it is important to highlight that the neurobiological changes observed are correlated with the reduction in IGD severity, but causality cannot be established. Further research is necessary to better understand the clinical potential of ApBMt in treating IGD, either as a stand-alone intervention or in combination with other therapeutic approaches.
Richards VL, Oliver JA, Pan SJ
… +4 more, Frank-Pearce SG, Smith MA, Nagawa CS, Cohn AM
Addict Behav
· 2026 Jan · PMID 41021996
·
Full text
BACKGROUND: E-cigarette use has grown in popularity and is independently associated with alcohol use and mental health (anxiety/depression), but the interactions between alcohol and anxiety/depression with e-cigarette us...BACKGROUND: E-cigarette use has grown in popularity and is independently associated with alcohol use and mental health (anxiety/depression), but the interactions between alcohol and anxiety/depression with e-cigarette use have not been examined. We examined whether anxiety/depression would influence the association of both alcohol use frequency and heavy episodic drinking (HED) with e-cigarette use frequency, hypothesizing that alcohol use would be more strongly related to e-cigarette use among those with current anxiety/depression. METHODS: N = 11,006 adults (55 % female; 71 % non-Hispanic White, M age = 42) completed assessments of demographics, past 30-day e-cigarette and alcohol use, and current symptoms of anxiety and depression. Regression models including past 30-day e-cigarette users only (N = 2,395) examined the moderating effects of anxiety/depression (yes/no) on the alcohol-e-cigarette frequency relationship, examining alcohol use frequency and HED separately. RESULTS: More than one-fifth (21.7 %) of the total sample reported any past 30-day e-cigarette use. Among e-cigarette users, past 30-day alcohol use frequency was associated with e-cigarette use frequency but did not significantly differ by mental health status (IRR = 1.02, 95 % 1.01, 1.02). HED was not associated with e-cigarette use frequency, regardless of mental health status (IRR = 1.02; 95 % CI: 0.93, 1.11). CONCLUSION: The relationship between current alcohol use and e-cigarette use frequency was not statistically different between individuals who endorsed current anxiety and/or depression vs. those who did not. Findings support the need to consider other substance use within e-cigarette smoking prevention and cessation efforts. Additional longitudinal research is needed to infer directionality and causality.
RATIONALE: Impaired control over alcohol use is a core aspect of Alcohol Use Disorder symptomatology. However, research regarding how impaired control manifests at the day-level, and what temporally proceeds it in daily...RATIONALE: Impaired control over alcohol use is a core aspect of Alcohol Use Disorder symptomatology. However, research regarding how impaired control manifests at the day-level, and what temporally proceeds it in daily life, remains underdeveloped. The current study tested whether three aspects of impaired control, namely restraint difficulties, drinking more than planned, and drinking longer than planned, had shared versus unique variability within- and between-individuals, and if pre-drinking positive and negative affect predicted such variability. METHODS: College students (N = 256) completed 14-days of ecological momentary assessment. Morning surveys assessed prior-day drinking, and random surveys assessed positive/negative affect, drinking behavior, and impaired control. Multilevel models tested the structure of day-level impaired control items within- and between-individuals and their pre-drinking affective antecedents. RESULTS: At the within-person level, day-level restraint difficulties, drinking more than planned, and drinking longer than planned loaded well onto a latent factor, whereas between-person drinking more than planned loaded onto a latent factor highly but restraint difficulties and drinking longer than planned did not. Pre-drinking affect did not predict latent factors at either level. However, when specifying items as correlated outcomes, deviations in pre-drinking positive and negative affect predicted drinking more than planned at the within-person level and person-aggregated pre-drinking negative affect predicted restraint difficulties at the between-person level. Findings did not differ as a function of hazardous drinking. CONCLUSIONS: Findings demonstrate complexities of modeling impaired control items within- and between-individuals and suggest that pre-drinking affect was related to drinking more than planned and restraint difficulties, albeit in different ways.