Searches / Am. J. Med. [JOURNAL]

Am. J. Med. [JOURNAL]

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What are we treating? The need for broader provider understanding of POTS, its nature, and care.

Reyes JL, Fedorowski A, Deering T … +10 more , Grubb B, Kenny RA, Lim PB, Olshansky B, Sandroni P, Raj SR, Sheldon RS, Stewart J, Sutton R, Benditt DG

Am J Med · 2026 Jun · PMID 42248496 · Publisher ↗

Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically > 3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lighth... Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically > 3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lightheadedness, and near-syncope) in the absence of orthostatic hypotension (ie, absence of a sustained systolic blood pressure drop > 20mmHg with upright posture). More recently, however, the :POTS: landscape as applied by many clinicians has broadened; the term :POTS: has become increasingly used to categorize a multisystem disorder the underlying etiologies of which remain unclear but may include autonomic dysfunction and/or autoimmune disorders; as such the clinical picture has evolved to encompass a wide range of non-cardiovascular symptoms such as persistent exertional intolerance, fatigue, "brain fog", thermo-regulatory disorders, and various gastrointestinal symptoms including gastroparesis and certain food intolerance reactions. Thus, while cardiovascular disorders may be the principal manifestation of presumed "POTS" in many patients, disturbances in a variety of body systems may dominate the clinical presentation in others. This communication, derived from a diverse group of practitioners who care for the wide range of patients often referred for :suspected POTS:, offer the view that optimizing diagnostic evaluation and subsequent care of these individuals necessitates a broad range of clinical skills; in essence involvement of a "village" of dedicated multi-talented care providers.
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Sustaining undergraduate medical education leadership: An AAIM statement on protected time and support for internal medicine clerkship directors.

Kwan B, Ratcliffe T, Merrill E … +5 more , Berman R, Cooney K, Masucci N, Servánt J, Anderson I

Am J Med · 2026 Jun · PMID 42248495 · Publisher ↗

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Artificial intelligence and the art of medicine.

Monico E, Thomas P

Am J Med · 2026 May · PMID 42214535 · Publisher ↗

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The Reply.

Lane JE, Greene L

Am J Med · 2026 Jul · PMID 42203410 · Publisher ↗

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Cutaneous sarcoidosis.

Bachmeyer C, Capriles S

Am J Med · 2026 Jul · PMID 42203409 · Publisher ↗

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The Reply.

Lane JE, Smith Hand C

Am J Med · 2026 Jul · PMID 42203408 · Publisher ↗

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Empiric antibiotic treatment in patients with dog bite.

Gozdas HT, Yunusoglu O

Am J Med · 2026 Jul · PMID 42203407 · Publisher ↗

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The Reply.

Kurihara M, Yanagita Y, Yokokawa D … +2 more , Fujii H, Uehara T

Am J Med · 2026 Jul · PMID 42203406 · Publisher ↗

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Relationship between microcytosis and hypochromia in non anemic iron deficiency.

Jolobe OM

Am J Med · 2026 Jul · PMID 42203405 · Publisher ↗

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The Reply.

Atias D, Gerber Y, Hasin T … +1 more , Obolski U

Am J Med · 2026 Jul · PMID 42203404 · Publisher ↗

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Further reflections on predicting trajectories in the dynamic six-minute walk test.

Wang H

Am J Med · 2026 Jul · PMID 42203403 · Publisher ↗

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The Jevons trap: When artificial intelligence in healthcare creates endless work.

Shankar R

Am J Med · 2026 May · PMID 42191014 · Publisher ↗

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Acute lung injury following near-drowning.

Wang F, Wang H

Am J Med · 2026 May · PMID 42191013 · Publisher ↗

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A superficial femoral lesion.

Qin DA, Shi XC, Hu YJ

Am J Med · 2026 May · PMID 42177929 · Publisher ↗

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Folate testing: Time to consider its overuse.

O'Neill Z, Neitzel A, McCudden C … +4 more , Wooller K, Khalife R, Ruller S, Gaudreau-Simard M

Am J Med · 2026 May · PMID 42176969 · Publisher ↗

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Can drones deliver platelet concentrates? A pilot study.

Funk-Hilsdorf T, Pruß A, Leitert T … +6 more , Koehler K, Assefa B, Fleischhauer K, Vettorazzi E, Hindricks G, Koehler F

Am J Med · 2026 May · PMID 42176968 · Publisher ↗

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Generational shifts in the physician workforce: Implications for practice, culture, and innovation.

Gettel CJ, Gerhardt M, Safdar B … +1 more , Venkatesh AK

Am J Med · 2026 May · PMID 42176967 · Publisher ↗

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Diagnostic utility and utilization of abdominal X-rays for constipation in adult medical inpatients.

Neitzel A, Shore I, Wooller K … +5 more , McNeill K, Hasimja D, Goy C, Walsh C, Gaudreau-Simard M

Am J Med · 2026 May · PMID 42176966 · Publisher ↗

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Effect of cumulative blood pressure exposure on long-term cardiovascular outcomes in the community, a nationwide cohort study.

Avrahami D, Zahger D, Arbel R … +4 more , Rokach L, Razi T, Sergienko R, Barda N

Am J Med · 2026 May · PMID 42173468 · Publisher ↗

BACKGROUND: Cardiovascular risk prediction models use single blood pressure measurements. Cumulative blood pressure exposure over time may better predict cardiovascular events. METHODS: We used data from a large communit... BACKGROUND: Cardiovascular risk prediction models use single blood pressure measurements. Cumulative blood pressure exposure over time may better predict cardiovascular events. METHODS: We used data from a large community database to examine the incremental value of 10-year cumulative blood pressure exposure over standard risk based on a single value using the Pooled Cohort Equations (PCE). The index date was set to January 1, 2018, with a 5-year prediction horizon and 10 years of prior exposure. Individuals included were 45 years of age or older, had no known cardiovascular disease and had at least 3 prior blood pressure values. The primary exposure was cumulative blood pressure over the previous 10 years, expressed as the area under the systolic blood pressure curve over 140 mmHg. We assessed the model's ability to improve prediction of "Hard cardiovascular disease" (cardiac mortality, myocardial infarction or stroke), stroke and all cause mortality beyond that achieved by the PCE. RESULTS: Our cohort of 614,084 individuals was divided into a derivation set of 428,826 and a validation set of 184,222 individuals. The C statistic improved by 0.8% (95% CI: 0, 0.8%), 1.3% (1.0, 1.7%), and 0% (0, 0.1%), and continuous net reclassification improvement was 0.492, 0.656 and 0.539 for the "Hard cardiovascular disease", stroke, and all-cause mortality outcomes, respectively. CONCLUSIONS: Cumulative blood pressure exposure over 10 years significantly improves the prediction of incident cardiovascular events and mortality above that derived from a single value. Introduction of cumulative blood pressure exposure into electronic health records might facilitate personalized risk prediction.
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Misinformation blaming and labelling may damage health, science and policy making.

Schippers MC, Vermeulen N, Ioannidis JPA

Am J Med · 2026 May · PMID 42173467 · Publisher ↗

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