J BUON [JOURNAL]
Sun
200 papers
Application value of Doppler ultrasound combined with CA125 and CA19.9 in the early diagnosis of epithelial ovarian cancer.
Cui Y, Shi S, Zhang S … +3 more , Huang C, Li P, Han C
J BUON · 2021 · PMID 34761586
PURPOSE: An early diagnosis is of great significance in improving the survival rate of patients. At present, the application values of different diagnostic methods in ovarian cancer are different, and the clinical diagno...
PURPOSE: An early diagnosis is of great significance in improving the survival rate of patients. At present, the application values of different diagnostic methods in ovarian cancer are different, and the clinical diagnosis alone is not ideal. Therefore, this study explored the application value of Doppler ultrasound combined with CA125 and CA19.9 in the early diagnosis of epithelial ovarian cancer. METHODS: A total of 58 patients with ovarian diseases were divided into an observation group (epithelial ovarian cancer group, n=29) and a control group (benign ovarian tumour group, n=29). Doppler ultrasound results and serum CA125 and CA19.9 detection results of the two groups were collected to analyse and compare the application values of ultrasound and different kinds of tumour markers in the early diagnosis of epithelial ovarian cancer. RESULTS: The results of Doppler ultrasound showed that the resistance index of the blood flow in the observation group was lower than that in the control group, and the ultrasound score was higher than that in the control group (p<0.05). The levels of serum tumour markers CA125 and CA19.9 in the observation group were significantly higher than those in the control group (p<0.05). The results of the repeated measurement analysis of variance showed that there were significant differences in the ultrasound score, blood flow resistance index, and CA125 and CA19.9 levels in different stages of ovarian cancer (p<0.05). There was no difference in the ultrasonographic score between stage I and the partum stage, while the stages of menstruation and implantation showed a gradually increasing trend (p<0.05). The blood flow resistance index and CA125 and CA19.9 levels increased gradually with the stage (p<0.05). The sensitivity (93.1%), specificity (96.55%), positive predictive value (96.43%), negative predictive value (93.33%) and diagnosis rate (94.83%) of Doppler ultrasonography combined with CA125 and CA19.9 in the diagnosis of epithelial ovarian cancer were higher than those of the single indicator detection method or the two combined diagnostic detection methods. CONCLUSION: Doppler ultrasound combined with CA125 and CA19.9 has high sensitivity, high specificity and high coincidence rate and can improve the early clinical diagnosis of epithelial ovarian cancer.
Efficacy of laparoscopic, pelvic and para-aortic lymphadenectomy in the treatment of endometrial carcinoma.
Wang H, Li W, Li N
J BUON · 2021 · PMID 34761585
PURPOSE: To investigate the clinical efficacy and safety of laparoscopic pelvic and para-aortic lymphadenectomy in the treatment of endometrial carcinoma. METHODS: The clinical data of 110 patients with endometrial carci...
PURPOSE: To investigate the clinical efficacy and safety of laparoscopic pelvic and para-aortic lymphadenectomy in the treatment of endometrial carcinoma. METHODS: The clinical data of 110 patients with endometrial carcinoma were retrospectively reviewed. All patients were categorized into two groups. The pelvic lymphadenectomy (PLD) group was subjected to pelvic lymph node dissection alone, while the para-aortic lymphadenectomy (PALD)+PLD group underwent pelvic and para-aortic lymphadenectomy. The operation time, intraoperative bleeding, volume of postoperative drainage, number of resected lymph nodes, number of positive lymph nodes, and incidence of postoperative complications were compared between the two groups of patients. In addition, the tumor recurrence and survival were followed up and compared. RESULTS: The operation time was significantly longer in the PALD+PLD group than that in the PLD group (p<0.001). The average number of resected lymph nodes and the number of positive lymph nodes in the PALD+PLD group were significantly greater than those in the PLD group. The total recurrence rate was 9.1% (5/55) vs. 20.0% (11/55) between the PLD group and PALD+PLD group, indicating a statistically significant difference (p=0.045). Moreover, the recurrence rate of stage III patients was 50.0% (3/6) and 25.0% (5/55) in the PLD group and PALD+PLD group, respectively, showing a statistically significant difference (p=0.034). During the follow-up period, the 3-year overall survival (OS) was 90.9% (50/55) and 96.4% (53/55) in the PLD group and PALD+PLD group, respectively, indicating no statistically significant difference (p=0.249, log-rank test). CONCLUSION: Laparoscopic pelvic and para-aortic lymphadenectomy for endometrial carcinoma can increase the number of resected lymph nodes and reduce the recurrence rate. Moreover, it does not increase the incidence rate of surgical complications.
Effects of GATA6-AS/MMP9 on malignant progression of endometrial carcinoma.
Zhao Y, Zou X, Wang G … +4 more , Liu Y, Zhang C, Lu W, Li Q
J BUON · 2021 · PMID 34761584
PURPOSE: Previous studies have shown that long non-coding RNA (lncRNA) GATA6-AS is a tumor suppressor gene. However, the role of GATA6-AS in endometrial cancer (EC) has not been reported. We aimed at investigating the ex...
PURPOSE: Previous studies have shown that long non-coding RNA (lncRNA) GATA6-AS is a tumor suppressor gene. However, the role of GATA6-AS in endometrial cancer (EC) has not been reported. We aimed at investigating the expression characteristics of GATA6-AS in EC tissues and cell lines, and explored whether it inhibits the malignant progression of EC through modulating matrix metalloproteinase-9 (MMP9). METHODS: GATA6-AS expression in 17 pairs of EC tissues and adjacent ones was studied by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Meanwhile, GATA6-AS expression levels in EC cell lines were also evaluated by qRT-PCR assay. In addition, GATA6-AS overexpression model was constructed using lentivirus in EC cell lines KLE and HEC-1B. The impacts of GATA6-AS overexpression model was constructed using lentivirus in EC cell lines KLE and HEC-1B on the proliferation capacity and apoptosis of EC cells were assessed by cell counting kit-8 (CCK-8), 5-Ethynyl-2'- deoxyuridine (EdU), and flow cytometry experiments. Furthermore, we explored the interaction between GATA6-AS and MMP9 in EC cells via performing luciferase assay and cell reverse experiments. RESULTS: Our data showed that GATA6-AS expression in EC tissue specimens was remarkably lower than that in adjacent ones. In vitro cell experiments revealed that overexpression of GATA6-AS markedly attenuated the proliferation ability of EC cells while elevated their apoptosis. Meanwhile, luciferase assay confirmed the binding relationship between GATA6-AS and MMP9. In addition, cell reverse experiments further demonstrated the mutual regulation between GATA6-AS and MMP9, which was, overexpression of MMP9 reversed the inhibitory influence of upregulation of GATA6-AS on the malignant progression of EC. CONCLUSIONS: lncRNA GATA6-AS, lowly expressed in EC tissue samples. Additionally, lncRNA GATA6-AS may suppress the malignant progression of EC through the modulation of regulating MMP9.
miR-99a inhibits proliferation and migration of cervical cancer cells by targeting IGF1R.
Han L
J BUON · 2021 · PMID 34761583
PURPOSE: To explore the effects of miR-99a on the proliferation and migration of cervical cancer cells (CCCs) by targeting IGF1R. METHODS: miR-99a and IGF1R expression in C-33 A and C-4 II cells was interfered. Their eff...
PURPOSE: To explore the effects of miR-99a on the proliferation and migration of cervical cancer cells (CCCs) by targeting IGF1R. METHODS: miR-99a and IGF1R expression in C-33 A and C-4 II cells was interfered. Their effects on the proliferation, apoptosis, and migration of CCCs were analyzed by MTT assay, flow cytometry, and Transwell assay. The mechanism of action of miR-99a was analyzed by a rescue experiment and a dual luciferase reporter gene assay (DLRGA). Differences in miR-99a and IGF1R expression were detected in cervical cancer and adjacent tissues (n=30 each), and the correlation of the expression with clinicopathological characteristics of patients with cervical cancer was analyzed. RESULTS: miR-99a expression was lower but IGF1R expression was higher in C-33 A and C-4 II cells than that in normal cervical epithelial cells. The results showed that both the promotion and the inhibition significantly decreased the proliferation and migration of the two CCCs, but increased their apoptosis. To further verify the correlation of miR-99a with IGF1R in cervical cancer, we co-transfected miR-99a and IGF1R overexpression vectors into the cells and found that compared with CCCs transfected with miR-99a overexpression vectors alone, the expression of IGF1R in the co-transfection group increased, while the expression of miR-99a did not change significantly. Additionally, the proliferation and migration of the cells in the co-transfection group increased, while their apoptotic rate decreased. DLRGA showed the targeted inhibition of miR-99a on IGF1R expression. CONCLUSIONS: miR-99a can specifically inhibit IGF1R expression and thus inhibit the proliferation and migration of CCCs.
Dilatation and curettage in endometrial cancer. What is the correlation with hysterectomy histology? A 14 years retrospective cohort study.
Liberis A, Mareti E, Pratilas G … +7 more , Petousis S, Daniilidis A, Vatopoulou A, Pantazis K, Chatzinikolaou F, Miliaras D, Dinas K
J BUON · 2021 · PMID 34761582
PURPOSE: The aim of the present study is to evaluate the concordance between preoperative endometrial sampling histopathology performed by conventional dilatation and curettage (D&C) and final histopathological diagnosis...
PURPOSE: The aim of the present study is to evaluate the concordance between preoperative endometrial sampling histopathology performed by conventional dilatation and curettage (D&C) and final histopathological diagnosis after total hysterectomy concerning tumor grade and subtype in patients with endometrial cancer (EC). METHODS: In this comparative retrospective study, 203 women with endometrial cancer were included who underwent at first dilatation and curettage and then total hysterectomy. The preoperative histopathological report obtained by dilatation and curettage was compared with the final histopathology after total hysterectomy to assess the accuracy of endometrial sampling. RESULTS: Comparison of preoperative with postoperative histopathological results showed an overall 5.9% and 10.9% discordance regarding endometrial cancer histological subtype and grade, respectively. Six (4.9%) of the patients with preoperative grade 1 were grade 2 and 1 (0.8%) was found to be grade 3. Three (8.3%) of the patients with preoperative grade 2 were found to be grade 3 after hysterectomy. Discordance is higher for endometrioid endometrial cancer grade 2 (25%) compared with grade 1 (5.7%) and 3 (18.8%). CONCLUSION: Patients should be informed and consent for the potential discrepancy between the pre and postoperative histopathological features of malignancy. This discrepancy may result in either under or overtreatment. Thus, it should be accounted for when counseling for a major operation.
miR-34a-5p blocks cervical cancer growth and migration by downregulating CDC25A.
Jiang T, Cheng H
J BUON · 2021 · PMID 34761581
PURPOSE: To define mechanisms underlying the regulation of CDC25A by miR-34a-5p in cervical cancer (CC). METHODS: Quantifications of miR-34a-5p and CDC25A levels were performed in 68 CC tissues and matched controls. CC c...
PURPOSE: To define mechanisms underlying the regulation of CDC25A by miR-34a-5p in cervical cancer (CC). METHODS: Quantifications of miR-34a-5p and CDC25A levels were performed in 68 CC tissues and matched controls. CC cell lines HeLa and SiHa were transfected to monitor their biological behavior changes. RESULTS: Low-expressed miR-34a-5p and up-regulated CDC25A were noted in CC. Either overexpression of miR-34a-5p or inhibition of CDC25A blocked the growth and migration of HeLa and SiHa cells, resulting in an increase in apoptosis (p<0.05), while inhibition of miR-34a-5p or overexpression of CDC25A promoted tumor growth. Dual-luciferase reporter (DLR) assay and cell transfection identified the targeting relationship between miR-34a-5p and CDC25A, and correlation analysis revealed a negative association between them in CC. Co-transfection assays showed that overexpression of CDC25A reversed the inhibition of miR-34a-5p on CC growth and migration. CONCLUSION: miR-34a-5p mediates growth, migration and other malignant behaviors in CC by regulating CDC25A.
Obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients.
Yoshida H, Shintani D, Fujiwara K
J BUON · 2021 · PMID 34761580
PURPOSE: Bevacizumab, an anti-angiogenic agent targeting vascular endothelial growth factor (VEGF), is widely used for the treatment of ovarian cancer. However, no predictive biomarkers of clinical outcome for bevacizuma...
PURPOSE: Bevacizumab, an anti-angiogenic agent targeting vascular endothelial growth factor (VEGF), is widely used for the treatment of ovarian cancer. However, no predictive biomarkers of clinical outcome for bevacizumab therapy have been identified. Adipose tissue secretes various growth factors, including VEGF, which may neutralize bevacizumab and attenuate its effects. Therefore, we evaluated whether obesity is a predictive biomarker of clinical outcome in ovarian cancer patients treated with single-agent bevacizumab. METHODS: Thirty patients with recurrent ovarian cancer treated with single-agent bevacizumab were studied. Body mass index (BMI) and visceral fat area (VFA) were measured to assess the presence of obesity. VFA was measured using computed tomography volume-analyzing software. The association of BMI and VFA with clinical outcomes were evaluated. RESULTS: High BMI and high VFA were significantly correlated with progressive disease (p=0.0195 and p=0.0352, respectively). A significant correlation was identified between high BMI and progressive disease in multivariate analysis (p=0.0459). Furthermore, there was a trend toward shorter progression-free survival and a significant shortening of overall survival in high-BMI patients compared with low-BMI patients (p=0.101 and p=0.0417, respectively). CONCLUSIONS: This study demonstrated that obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients. Obesity may be a useful benchmark for the administration of bevacizumab in daily clinical practice.
Ovarian cancer: 20-year experience with cytoreductive surgery and perioperative intraperitoneal chemotherapy.
Ntatsis K, Papantoni E, Kyziridis D … +4 more , Kalakonas A, Hristakis C, Tzavara C, Tentes AA
J BUON · 2021 · PMID 34761579
PURPOSE: Complete cytoreduction has been established as the most significant factor of long-term survival in epithelial ovarian cancer. Perioperative intraperitoneal chemotherapy has been added in the treatment of ovaria...
PURPOSE: Complete cytoreduction has been established as the most significant factor of long-term survival in epithelial ovarian cancer. Perioperative intraperitoneal chemotherapy has been added in the treatment of ovarian cancer the last 20 years. The purpose of the study was to determine the outcome of women with ovarian cancer using the data of one surgical team. METHODS: Women with ovarian cancer treated from 2000 to 2019 by the same surgical team were enrolled in the study. The patients underwent cytoreductive surgery combined with perioperative intraperitoneal chemotherapy. Clinical and histopathological variables were correlated to hospital mortality, morbidity, survival and recurrences. RESULTS: The mean age of 350 women was 59.5+11.7 years. The hospital mortality and morbidity rate were 2.0% and 28.3%, respectively. Complete cytoreduction was possible in 60% of the cases. The overall 5- and 10-year survival rate was 47% and 39%, respectively. The prognostic variables of survival were the extent of peritoneal malignancy, the extent of previous surgery, the grade of differentiation, the use of adjuvant chemotherapy, the lymphadenectomy of the resected large bowel, and the postoperative morbidity. The recurrence rate was 45.7%. The extent of peritoneal carcinomatosis, the extent of previous surgery, and the grade of differentiation were the prognostic variables of recurrence. CONCLUSIONS: The limited extent of peritoneal carcinomatosis in women with well differentiated ovarian cancer that do not have history of previous surgery, who undergo standard pelvic peritonectomy procedure, and receive adjuvant chemotherapy are expected to be long-term survivors.
Chyle leak after major pancreatic surgery. Is this an underestimated complication? A narrative review of the literature.
Vailas M, Sotiropoulou M, Benetatos N … +3 more , Mulita F, Maroulis I, Germanos S
J BUON · 2021 · PMID 34761578
PURPOSE: Postoperative chyle leak, termed 'chylous ascites', is a rare complication with a reported frequency of only one in 20464 abdominal operations. The purpose of this study was to summarize the available scientific...
PURPOSE: Postoperative chyle leak, termed 'chylous ascites', is a rare complication with a reported frequency of only one in 20464 abdominal operations. The purpose of this study was to summarize the available scientific data reviewing the most relevant studies for this type of postoperative complication after pancreatic surgery, highlighting at the same time the necessity for pancreatic surgeons to retain a high level of clinical suspicion for the early diagnosis and its therapeutic management. METHODS: A thorough literature search in Pubmed and Google Scholar, under the terms' chylous ascites OR chyle leak AND pancreas OR pancreatic', since the year of inception until 19th of February 2021 was conducted by the authors and the associated results are presented in this narrative review. RESULTS: Chyle leak is a rare complication following pancreatic surgery. Patients may suffer from exudative enteropathy and malnutrition leading to repeated infections and impaired wound healing or even death secondary to sepsis. Several studies have highlighted the issue of increased hospital stay, while others failed to reach statistical significance as far as hospital stay or survival are concerned. Researchers found that patients with diffuse chyle leak tended to have a worse 3-year survival rate (18.8%), which can be attributed to postoperative complications and early demise due to immunosuppression associated with the leak, or delayed adjuvant chemotherapy Conclusion: Further clinical research is needed to enhance prevention, diagnosis, treatment and long-term prognosis of this relevant surgical problem that shows trends of increase due to the great number of major operations which are performed nowadays.
The surgical challenge of oligometastatic pancreatic cancer: A systemic review of the literature.
Christodoulidis G, Magouliotis E, Samara AA … +4 more , Floros T, Zotos PA, Tolia M, Zacharoulis D
J BUON · 2021 · PMID 34761577
PURPOSE: We aim to review the available literature on surgical management of oligometastatic pancreatic ductal adenocarcinoma (PDAC), in order to assess the clinical outcomes and intraoperative parameters of the differen...
PURPOSE: We aim to review the available literature on surgical management of oligometastatic pancreatic ductal adenocarcinoma (PDAC), in order to assess the clinical outcomes and intraoperative parameters of the different strategies. METHODS: A systematic literature search was performed in PubMed database, in accordance with the PRISMA guidelines. Nine studies met the inclusion criteria incorporating 401 patients. RESULTS: Perioperative mortality was as low as 0%, regarding resection of pancreatic cancer combined with synchronous metastasectomy. CONCLUSIONS: Currently, postoperative overall survival and progression-free survival have increased compared to previous trials. Nevertheless, the lack of precise operative indications delays the enhancement of survival rates. Well-designed, randomized controlled studies, assessing pancreatic surgery combined with metastasectomy, are necessary to further assess their clinical outcomes.
Diagnosis, treatment and quality of life in patients with cancer-related lymphedema.
Kalemikerakis I, Evaggelakou A, Kavga A … +3 more , Vastardi M, Konstantinidis T, Govina O
J BUON · 2021 · PMID 34761576
Cancer-related lymphedema is the result of surgical operation or radiation therapy of the corresponding lymph nodes and is due to the obstruction of the lymphatic drainage in the affected area. In lymphedema the lymphati...
Cancer-related lymphedema is the result of surgical operation or radiation therapy of the corresponding lymph nodes and is due to the obstruction of the lymphatic drainage in the affected area. In lymphedema the lymphatic stasis causes an inflammatory reaction that leads to the proliferation of adipose tissue and fibrosis, resulting in mild to severe permanent swelling of the affected part of the body. It is more often found in the upper extremities of women with breast cancer. It may, however, appear at one or more extremities and may include the corresponding quadrant of the trunk. It may also affect head and neck, breast, genitals and lower extremities, depending on the surgery the patient has undergone. It is often associated with obesity (BMI>40). Early diagnosis and treatment of lymphedema is related with better therapeutic outcome. Women with breast cancer confront more problems with lymphedema than with mastectomy. Its effect on patients' quality of life is relevant to changes in body image, self-esteem, feelings of weakness, fear and anxiety about disease progression, financial costs, and reduced limb function. More recent studies support the effectiveness of contemporary surgical techniques in lymphedema's treatment. In conservative management, CDT remains the treatment of choice and in combination with exercise, weight control programs and self-care training seems to significantly improve patients' quality of life.
Basic principles of molecular biology of cancer cell-Molecular cancer indicators.
N Kontomanolis E, Koutras A, Syllaios A … +7 more , Schizas D, Kalagasidou S, Pagkalos A, Alatzidou D, Kantari P, Ntounis T, Fasoulakis Z
J BUON · 2021 · PMID 34761575
Molecular biology of cancer cell is a domain of medical science that is rapidly growing in our days. Knowing the ways and paths that cancer cells follow is crucial to the prevention of cancer itself. Central role to thes...
Molecular biology of cancer cell is a domain of medical science that is rapidly growing in our days. Knowing the ways and paths that cancer cells follow is crucial to the prevention of cancer itself. Central role to these paths, concerning the cell cycle and the process of apoptosis, has the protein p53. The whole mechanism of the cell cycle is activated by the action of various mitogens, such as growth factors, hormones and cytokines. Carcinogenesis involves alterations of genes (proto-oncogenes and tumor suppressor genes), which encode proteins of the signal transduction. Many of the damages that lead to carcinogenesis may be due to the lack of repressive signals for cell division, but also to the absence of the sensitivity of cells to repressive signals. The cell has mechanisms of receiving apoptotic-antitumor signals and mechanisms of execution of these instructions. A percentage of cancers (4-8%) are etiologically linked to germ (stem) cells mutations and occur at an increased frequency in families (hereditary cancers). Substantial progress in understanding the mechanisms of carcinogenesis, filtration and metastasis of cancer has highlighted the key role of specific genes, primarily oncogenes and tumor suppressor genes.
Impact of SARS-CoV-2 infection on oral carcinoma patients.
Ragos V, Adamopoulou M, Manoli A … +11 more , Katsinis S, Papouliakos S, Dimas O, Tsiambas E, Roukas D, Papanastasiou G, Spyropoulou D, Manaios L, Asimakopoulos A, Mastronikolis N, Anthouli Anagnostopoulou F
J BUON · 2021 · PMID 34761574
Coronavirus-related Severe Acute Respiratory Syndrome (SARS-CoV) in 2002/2003, Middle-East Respiratory Syndrome (MERS-Cov) in 2012/2013, and especially the current 2019/2020 Severe Acute Respiratory Syndrome-2 (SARS-CoV-...
Coronavirus-related Severe Acute Respiratory Syndrome (SARS-CoV) in 2002/2003, Middle-East Respiratory Syndrome (MERS-Cov) in 2012/2013, and especially the current 2019/2020 Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) tested the national health systems' endurance worldwide. In order to fight this emergency situation, a variety of pharmaceutical companies focused on the design and development of efficient vaccines that are considered necessary for providing a level of normalization in totally affected human social-economical activity worldwide. COVID-19 led to an increased uncertainty in the field of oncological patients' management disrupting the normal conditions of therapeutic and monitoring procedures. In the current article, we explored the impact of SARS-CoV-2 infection on oral carcinoma patients. We observed COVD-19 pandemic negatively affects the normality regarding early diagnosis and optimal management (surgical operation, post-operational follow up/monitoring) in HNSCC/OSCC patients. Understanding the involvement of SARS-CoV-2 in the progression of malignancies is the first critical step for targeting the virus by efficient monoclonal antibodies and vaccines.
Cigarette smoking and medical students.
Prijić Ž, Igić R
J BUON · 2021 · PMID 34761573
Despite its well known harmful effects on health, tobacco use is widespread throughout the world. Approximately one third of the global population become smokers at the age of 15 years or more. The prevalence of smoking...
Despite its well known harmful effects on health, tobacco use is widespread throughout the world. Approximately one third of the global population become smokers at the age of 15 years or more. The prevalence of smoking between genders is lessening. Earlier, men used to smoke three to four times more than women globally. The nicotine content of cigarette is small (10 to 12 mg) and a smoker inhales about 1.1 to 1.8 mg of nicotine from each cigarette smoked to its entire length; this plant alkaloid stimulates the central nervous system, causes either ganglionic stimulation in low doses or ganglionic blockade in high doses, and smokers can develop a moderate to heavy physical dependence. Among other numerous substances, several are cancerogenic, and about 98 percent of lung cancer deaths are caused due to tobacco smoke. Nicotine addiction is often more severe than alcohol addiction. Smoking also may complicate anesthetic management, and passive smoking increases the rate of perioperative airway complications in the children of smokers, too. Preoperative abstinence from tobacco is required for surgical patients and it offers an opportunity for smokers to quit permanently. Physicians have an important role in helping smokers to quit tobacco or e-cigarettes, but if a doctor is a smoker himself, his antismoking influence may be deficient. Since a significant percentage of medical students are smokers, it is worth influencing them to stop the habit. The best way is to introduce tobacco modules, stimulating students to participate in anti-smoking campaigns, offer non-smoking hospitals, non-smoking university campuses, non-smoking dormitories, and to provide medical assistance to student smokers who wish to quit.
5G and human health.
Theodorou K, Tyrakis C, Softa V … +1 more , Kappas C
J BUON · 2021 · PMID 34761572
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Retraction Note to: Dammarenediol suppresses the growth, migration and invasion of human osteosarcoma cells by modulating PI3K/Akt and STAT-3 signaling pathways.
Wu Y, Chen Y, Xu Z … +1 more , Xiang M
J BUON · 2021 · PMID 34565053
Retraction of "Dammarenediol suppresses the growth, migration and invasion of human osteosarcoma cells by modulating PI3K/Akt and STAT-3 signaling pathways", by Yingbin Wu, Yue Chen, Zheng Xu, Ming Xiang. JBUON 2020;25(5...
Retraction of "Dammarenediol suppresses the growth, migration and invasion of human osteosarcoma cells by modulating PI3K/Akt and STAT-3 signaling pathways", by Yingbin Wu, Yue Chen, Zheng Xu, Ming Xiang. JBUON 2020;25(5):2444-2448; PMID: 33277868 Following the publication of the above article, readers drew to our attention that part of the data was unreliable: Figures of this article appeared in other articles (by totally different authors). The authors were requested to provide the raw data and were also asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. Given above, we decided to retract this article. Authors were informed of the retraction. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.
Retraction Note to: Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells.
Zhu D, Tian X, Yin X … +2 more , Yan H, Li W
J BUON · 2021 · PMID 34565052
Retraction of "Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells", by Dongliang Zhu, Xiaoling Tian, Xiaoping Yin, Haidong Yan, Weihao Li. JBUON 2020;25(5):2308-2314;...
Retraction of "Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells", by Dongliang Zhu, Xiaoling Tian, Xiaoping Yin, Haidong Yan, Weihao Li. JBUON 2020;25(5):2308-2314; PMID: 33277850 Following the publication of the above article, readers drew to our attention that part of the data was unreliable: Figures of this article appeared in other articles (by totally different authors). The authors were requested to provide the raw data and were also asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. Given above, we decided to retract this article. Authors were informed of the retraction. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.
Retraction Note to: MicroRNA-23 regulates the growth, metastasis and chemosensitivity of human gastric cancer cells by targeting MAP3K9.
Li D, Wang J, Hui Y … +3 more , Yang Y, Peng X, Sun C
J BUON · 2021 · PMID 34565051
Retraction of "MicroRNA-23 regulates the growth, metastasis and chemosensitivity of human gastric cancer cells by targeting MAP3K9", by Deping Li, Juan Wang, Yuanjian Hui, Yan Yang, Xingchun Peng, Shengbao Li, Chuantao S...
Retraction of "MicroRNA-23 regulates the growth, metastasis and chemosensitivity of human gastric cancer cells by targeting MAP3K9", by Deping Li, Juan Wang, Yuanjian Hui, Yan Yang, Xingchun Peng, Shengbao Li, Chuantao Sun. JBUON 2020;25(5):2315-2321; PMID: 33277851 Following the publication of the above article, readers drew to our attention that part of the data was unreliable: Figures of this article appeared in other articles (by totally different authors). The authors were requested to provide the raw data and were also asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. Given above, we decided to retract this article. Authors were informed of the retraction. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.
Retraction Note to: Lycopsamine inhibits the proliferation of human lung cancer cells via induction of apoptosis and autophagy and suppression of interleukin-2.
Yu Z, Guo G, Wang B
J BUON · 2021 · PMID 34565050
Retraction of "Lycopsamine inhibits the proliferation of human lung cancer cells via induction of apoptosis and autophagy and suppression of interleukin-2", by Zhengang Yu, Guifang Guo, Bingzhe Wang. JBUON 2020;25(5):235...
Retraction of "Lycopsamine inhibits the proliferation of human lung cancer cells via induction of apoptosis and autophagy and suppression of interleukin-2", by Zhengang Yu, Guifang Guo, Bingzhe Wang. JBUON 2020;25(5):2358-2363; PMID: 33277856 Following the publication of the above article, readers drew to our attention that part of the data was unreliable: Figures of this article appeared in other articles (by totally different authors). The authors were requested to provide the raw data and were also asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. Given above, we decided to retract this article. Authors were informed of the retraction. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.
Retraction Note to: HHIP gene overexpression inhibits the growth, migration and invasion of human liver cancer cells.
Wang X, Ma W, Yin J … +2 more , Chen M, Jin H
J BUON · 2021 · PMID 34565049
Retraction of "HHIP gene overexpression inhibits the growth, migration and invasion of human liver cancer cells", by Xiaobin Wang, Wenjie Ma, Jun Yin, Meizhu Chen, Hong Jin. JBUON 2020;25(5):2424-2429; PMID: 33277865 Fol...
Retraction of "HHIP gene overexpression inhibits the growth, migration and invasion of human liver cancer cells", by Xiaobin Wang, Wenjie Ma, Jun Yin, Meizhu Chen, Hong Jin. JBUON 2020;25(5):2424-2429; PMID: 33277865 Following the publication of the above article, readers drew to our attention that part of the data was unreliable: Figures of this article appeared in other articles (by totally different authors). The authors were requested to provide the raw data and were also asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. Given above, we decided to retract this article. Authors were informed of the retraction. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.
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