Planta Med. [JOURNAL]
Sun
200 papers
Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity.
Liangsakul P, Kuhakarn C, Jungsuttiwong S … +7 more , Intayot R, Thanasansurapong S, Akkarawongsapat R, Chairoungdua A, Nuntasaen N, Hongthong S, Reutrakul V
Planta Med · 2025 Aug · PMID 40239717 · Publisher ↗
Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were i...
Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were isolated from the bark of . Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1: ) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the MC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5: , and 8-11: showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.
A Neutral Glucan Extracted from Dried Ginger (Zingiberis Rhizoma): Preparation, Structure Characterization, and Immunomodulatory Activity.
Sun L, Ni X, Liu Y … +3 more , Jiang Y, Wang PP, Gao J
Planta Med · 2025 Sep · PMID 40228537 · Publisher ↗
A neutral glucan, GJ0D, was obtained from dried ginger (Zingiberis rhizoma) by enzymatic extraction and purification with column chromatography. The fine structure of GJ0D was assessed through monosaccharide composition...
A neutral glucan, GJ0D, was obtained from dried ginger (Zingiberis rhizoma) by enzymatic extraction and purification with column chromatography. The fine structure of GJ0D was assessed through monosaccharide composition analysis, methylation, and two-dimensional nuclear magnetic resonance. GJ0D has a relative molecular weight of 4.0 KDa and possesses a backbone consisting of 1,4-linked -Glc with substitution at C-6 of Glc by T-Glc. Immunoactivity assessment showed that GJ0D significantly upregulates the expression of IL-6, IL-1, and TNF- in RAW264.7 cells. The reactive oxygen species (ROS) production was also increased in RAW264.7 cells. In addition, the expression of several proteins associated with immune activation signaling pathways including TLR4, the phosphorylation of IKK, and NF-B (p100 and p52) were significantly upregulated by GJ0D. These results suggest that GJ0D could promote inflammation through the TLR4/IKK/P100 signaling pathway, suggesting a potential application as an immunomodulating agent.
Chemical Structural Elucidation and Immunomodulatory Activity of a New Polysaccharide from Saposhnikoviae Radix.
Cui Y, Fan H, Sun M … +5 more , He X, Li J, Tu G, Jiang Y, Liu B
Planta Med · 2025 Aug · PMID 40179971 · Publisher ↗
The chemical structure and immunomodulatory activity of a new homogeneous polysaccharide, SP4002501, isolated from Saposhnikoviae Radix (SR), were investigated. Purification of SP4002501 was performed by DEAE-Cellulose a...
The chemical structure and immunomodulatory activity of a new homogeneous polysaccharide, SP4002501, isolated from Saposhnikoviae Radix (SR), were investigated. Purification of SP4002501 was performed by DEAE-Cellulose and Sepharose CL-6B column chromatography. The monosaccharidic constituents were identified as rhamnose (Rha), galacturonic acid (GalA), galactose (Gal), and arabinose (Ara) with a molar ratio of 3.7: 86.6: 2.7: 7.1. According to the methylation analysis, partial hydrolysis, FT-IR, and NMR analysis, SP4002501 had a backbone of polygalacturonic acid units with a small amount of galactose (Gal). Side chains are connected to C-3 of galactose (Gal) and consist of rhamnose (Rha), galacturonic acid (GalA), galactose (Gal), and arabinose (Ara), with arabinose (Ara) as terminal sugar. Biological activity assessment suggests that SP4002501 exhibits immunomodulatory activity through promoting macrophage proliferation and phagocytosis.
Assessment of Tanshinone IIA Derivatives for Cardioprotection in Myocardial Ischemic Injury.
Wu Z, Xu Y, Guo X … +3 more , Zhang Z, Wang J, Tang Y
Planta Med · 2025 Jul · PMID 40127683 · Publisher ↗
Tanshinone ⅡA (TSA), a component of traditional Chinese medicine, effectively protects against myocardial injury. However, its clinical application is limited by poor water solubility and a short half-life. In this study...
Tanshinone ⅡA (TSA), a component of traditional Chinese medicine, effectively protects against myocardial injury. However, its clinical application is limited by poor water solubility and a short half-life. In this study, we report on four TSA derivatives designed and synthesized by our research group. The protective activity against hypoxia-reoxygenation injury in cells was evaluated, and derivative Ⅰ-3 was selected for experiments to verify its myocardial protective activity in rats with myocardial infarction. The results demonstrated that these four compounds could protect neonatal rat cardiomyocytes from hypoxia-reoxygenation injury. Among the derivatives, Ⅰ-3 showing superior protective effects, we found that Ⅰ-3 has enhanced metabolic stability and an extended half-life. Ⅰ-3 exhibited superior biological activity, effectively reducing the heart infarction area, alleviating myocardial hypertrophy, and enhancing cardiac pumping function. Ⅰ-3 reported in the present work represents a novel and effective derivative of TSA, showing great potential for the treatment of myocardial ischemia (MI).
Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota.
Ruan C, Gao W, Wang G … +4 more , Fan W, Zhang W, Tao S, Wu Z
Planta Med · 2025 Jul · PMID 40127682 · Publisher ↗
Ulcerative colitis (UC) is a persistent, periodically reoccurring inflammatory condition that impacts the gastrointestinal tract. Angelicone, a principal compound extracted from , may offer a potential alternative therap...
Ulcerative colitis (UC) is a persistent, periodically reoccurring inflammatory condition that impacts the gastrointestinal tract. Angelicone, a principal compound extracted from , may offer a potential alternative therapeutic approach for UC through the downregulation of inflammatory mediators. Nonetheless, the pharmacological impacts and molecular pathways of angelicone in UC management, particularly in relation to gut microbiota, remain unexplored. The current study scrutinized the modifications in gut microbiota in mice afflicted with UC, induced by 3% dextran sodium sulfate (DSS), utilizing 16S rRNA sequencing. The study demonstrated that angelicone substantially enhanced clinical indices, mitigated colonic damage, decreased cytokine levels, and reestablished the integrity of the intestinal epithelial barrier in UC mice. Furthermore, we discerned distinct bacterial genera that were responsive to angelicone treatment. Importantly, angelicone augmented the abundance of gut microbiota and partially reinstated the disrupted intestinal microbial composition, inclusive of the phyla , and . To summarize, our research offers novel perspectives into the intervention mechanisms of angelicone in the treatment of UC.
Recovery techniques for Hydroxynaphthoquinone Enantiomers of Alkanna tinctoria (L.) from Natural Deep Eutectic Solvents: A Comparative Analysis.
Bossard E, Tsafantakis N, Aligiannis N … +2 more , Chinou I, Fokialakis N
Planta Med · 2025 Jul · PMID 40112860 · Publisher ↗
A natural deep eutectic solvent (NaDES) composed of levulinic acid and glucose using a molar ratio of 5 : 1 (mol:mol) and 20% of water (w/w) (LeG_5_20) was found as a great alternative to the commonly used organic solven...
A natural deep eutectic solvent (NaDES) composed of levulinic acid and glucose using a molar ratio of 5 : 1 (mol:mol) and 20% of water (w/w) (LeG_5_20) was found as a great alternative to the commonly used organic solvents for the extraction of hydroxynaphthoquinone enantiomers (HNQs) from (L.) Tausch roots. In the present work, a comparative investigation of recovery methods for HNQs, such as solid-phase extraction, macroporous resin, and water as an anti-solvent, was performed to face the main disadvantage of NaDES: the inability to be evaporated. The highest recovery of HNQs was recorded using the solid-phase extraction on a reversed-phase C8 cartridge with a total hydroxynaphthoquinone content (TNC) of 46.79 ± 0.952 mg/g of dry weight (DW). In addition, a great recovery of HNQs was also reported for the macroporous resin Amberlite XAD 4 with a TNC value of 37.21 ± 1.789 mg/g DW, while the precipitation of HNQs by using water as an anti-solvent (1 : 5, v/v) offered a TNC value of 28.68 ± 0.023 mg/g DW. The macroporous resin Amberlite XAD also showed a great potential for larger-scale applications. In fact, the developed scale-up process, involving Amberlite XAD 4, showed a great recovery efficiency for HNQs (34.126 ± 1.093 mg/g DW), an acceptable robustness (RSD < 15%), and the possibility of recycling LeG_5_20 with a recovery greater than 50%; therefore, it is an excellent green alternative extraction procedure for HNQs.
Complex Standard Formulation as an Example for Synergism and Improved Antibacterial Activity Against Uropathogenic Escherichia coli for Urinary Tract Infections.
Boertz S, Dey M, Herrmann F … +4 more , Esch S, Sendker J, Dobrindt U, Hensel A
Planta Med · 2025 Jul · PMID 40112859 · Publisher ↗
For the treatment of urinary tract infections, mixtures of different herbal materials are frequently used within traditional clinical practice. A complex formulation, widely used in Germany for the preparation of aqueous...
For the treatment of urinary tract infections, mixtures of different herbal materials are frequently used within traditional clinical practice. A complex formulation, widely used in Germany for the preparation of aqueous extracts with sp., , and , was infused as a mixture from all four components (combined extract). In addition, the four herbs were extracted separately, and the extracts were mixed subsequently (separate extract). None of the extracts influenced the proliferation of UPEC-UTI89 and the cell viability of T24 bladder cells. The combined extract significantly reduced the activity of type-1 fimbriae of UPEC CFT073. This effect was not observed for the mixture of the separately extracted herbs. Systematic investigation of the combined extract and binary mixtures by LC-MS and bioassays indicated that a series of malonylated dammarane triterpenes from spp. leaves was extracted in the presence of sp. These dammaranes are responsible for the antiadhesive effect. The combined extract of sp. and BSC, as well as a dammarane-enhanced fraction (DEF), showed significant antiadhesive effects in a 2D-adhesion assay, as well as in three-dimensional RT4- bladder cell spheroids. RT-qPCR of UTI89 incubated with DEF indicated downregulation of , and with impact on the chaperone-usher system and correct pili formation. Increased expression of the motility gene indicates a switch from a static to a motile lifestyle. The S-fimbrial gene was significantly downregulated, but this did not result in phenotypic changes. Based on an improved extraction of birch leaf constituents, the data rationalize the importance of combinations of herbal drugs.
Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.
Sharifan A
Planta Med · 2025 Apr · PMID 40097172 · Publisher ↗
The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy fo...
The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were (n = 31, 84%), followed by studies (n = 4, 11%), with no or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.
Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimer's Disease.
Chen Z, Lu Y, Wang Y … +3 more , Wang Q, Yu L, Liu J
Planta Med · 2025 Jul · PMID 40086889 · Publisher ↗
Alzheimer's disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the th...
Alzheimer's disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting tau phosphorylation, a key factor in Alzheimer's disease progression. It comprehensively summarizes current research on various natural compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, and terpenoids, highlighting their multitarget mechanisms, such as modulating kinases and phosphatases. The ability of these compounds to mitigate oxidative stress, inflammation, and tau pathology while enhancing cognitive function underscores their value as potential anti-Alzheimer's disease therapeutics. By integrating recent advances in extraction methods, pharmacological studies, and artificial intelligence-driven screening technologies, this review provides a valuable reference for future research and development of natural product-based interventions for Alzheimer's disease.
Datura stramonium - A Dangerous Weed and Alternative Drug of Abuse: An Overview of Poisoning Cases in 21st Century.
Aćimović M
Planta Med · 2025 May · PMID 40086888 · Publisher ↗
is a well-known cosmopolitan weed known by several common names: thorn apple (due to the appearance of its fruits), Angel's trumpet (linked to its flowers), loco seed (referring to the hallucinogenic properties of its se...
is a well-known cosmopolitan weed known by several common names: thorn apple (due to the appearance of its fruits), Angel's trumpet (linked to its flowers), loco seed (referring to the hallucinogenic properties of its seeds), jimson weed (originating from the first recorded poisoning involving this plant), and apple of Peru (indicating the plant's origin). All parts of the plant contain the tropane alkaloids hyoscyamine, scopolamine, and atropine together with several minor alkaloids, which cause poisoning such as typical anticholinergic syndrome with neuropsychiatric effects. A review of 114 papers from various databases (Scopus, Web of Science, PubMed, and Google Scholar) revealed that poisoning incidents involving this plant have been relatively common from 2001 to 2024. The analysis indicated that all cases of poisoning from can be categorized into two main groups: accidental and misuse. Accidental poisonings are primarily linked to the contamination of other crops in the field, leading to mass poisoning of humans and animals. They can also result from misidentifying the plant as another edible species, children's curiosity, and self-medication. On the other hand, misuse is typically associated with recreational drug use, suicide attempts, criminal activities, and magico-religious practices. To prevent poisoning from this plant, it is essential to eliminate the weed from fields, yards, gardens, and other disturbed areas. Additionally, it is important to educate the general public about the plant's appearance and the dangers associated with its consumption, particularly in the context of self-medication and recreational drug use.
Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review.
Zhang S, Xie X, Zhao J … +7 more , Jiang Y, Huang C, Li Q, Xia B, Yin L, Yuan X, You Q
Planta Med · 2025 Apr · PMID 40054492 · Publisher ↗
Cardiovascular disease is one of the main causes of mortality worldwide. Andrographolide represents an important category of natural phytochemicals that has significant therapeutic potential in various conditions such as...
Cardiovascular disease is one of the main causes of mortality worldwide. Andrographolide represents an important category of natural phytochemicals that has significant therapeutic potential in various conditions such as acute lung injury, heart disease, and viral infections due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties. This compound plays a protective role in human pathophysiology. This review provides a comprehensive overview of the effects of andrographolide on cardiovascular disease and examines its essential roles and mechanisms in cardiovascular disease and other vascular dysfunctions. The data collected in this review serve as a comprehensive reference for the role of andrographolide in cardiovascular disease and provide valuable insights for further research and the development of andrographolide as a novel therapeutic approach for cardiovascular disease.
Anti-inflammatory Potential of Plants of Genus Rhus: Decrease in Inflammatory Mediators In Vitro and In Vivo - a Systematic Review.
Rodríguez-Castillo AJ, Pacheco-Tena C, Cuevas-Martínez R … +2 more , Sánchez-Ramírez BE, González-Chávez SA
Planta Med · 2025 Apr · PMID 40054491 · Publisher ↗
Plants from the genus are renowned for their medicinal properties, including anti-inflammatory effects; however, the mechanisms underlying these effects remain poorly understood. This systematic review, conducted follow...
Plants from the genus are renowned for their medicinal properties, including anti-inflammatory effects; however, the mechanisms underlying these effects remain poorly understood. This systematic review, conducted following PRISMA guidelines, evaluated the anti-inflammatory effects of plants and explored their potential pharmacological mechanisms. A total of 35 articles were included, with the majority demonstrating a low-risk bias, as assessed using the SYRCLE tool. , and were analyzed in the reviewed articles. studies consistently demonstrated the ability of plants to reduce key inflammatory mediators such as TNF-, IL-1, and IL-6. studies confirmed these effects in murine models of inflammation, with doses mostly of 400 and 800 mg/kg body weight, with no reports of toxicity. Fifty-four distinct inflammatory mediators were assessed ; no pattern of mediators was identified that could elucidate the anti-inflammatory mechanisms of the action of in acute or chronic inflammation. The clinical trial reported anti-inflammatory effects in humans at 1000 mg/kg for 6 weeks. The review data on the -mediated reduction in inflammatory mediators were integrated and visualized using the Reactome bioinformatics database, which suggested that the mechanism of action of involves the inhibition of inflammasome signaling. These findings support the potential of plants as a basis for developing anti-inflammatory therapies. Further research is needed to optimize dosage regimens and fully explore their pharmacological applications.
A Review on Phytochemistry and Recent Pharmacology of Dragon's Blood (Croton lechleri), a Multifunctional Ethnomedicinal Resource from the Amazon Forest.
de Albuquerque RDDG, León-Vargas FR, Carrasco-Montañez DD … +2 more , Carranza-Gonzales JL, Ramos-Rivas YVS
Planta Med · 2025 Jul · PMID 40043740 · Publisher ↗
, commonly known as "Sangre de Drago", is a widely utilized ethnomedicinal resource in the Amazon region, known for its diverse bioactive properties. These include wound-healing activity, anti-inflammatory effects, antit...
, commonly known as "Sangre de Drago", is a widely utilized ethnomedicinal resource in the Amazon region, known for its diverse bioactive properties. These include wound-healing activity, anti-inflammatory effects, antitumor activity, and other therapeutic benefits. Despite its extensive traditional use, a comprehensive review of the scientific studies conducted over the past two decades is lacking, which hinders a thorough understanding of the chemical and pharmacological characteristics of this species. Hence, this review is essential to inform researchers and readers about the current state of knowledge in this field. A systematic search was conducted using databases such as Scopus and Google Scholar, yielding 33 relevant articles focusing on the phytochemistry and recent pharmacological investigations of . These studies identify proanthocyanidins as the predominant phytochemical group in terms of relative quantity. Additionally, other significant phytochemical groups include alkaloids, diterpenoids, phytosteroids, saponins, phenolics, and polyphenolics. The pharmacological studies reviewed highlight several potential therapeutic effects of , particularly those associated with its resin. These effects include wound-healing, antitumor, anti-inflammatory, and gastrointestinal benefits, among others. The findings underscore the remarkable medicinal importance of this species, supporting its continued investigation and potential therapeutic applications.
Green Tea Catechins: A Promising Anticancer Approach for Leukaemia.
Mazur Ł, Balwierz R, Michalak K … +6 more , Michalak W, Jasińska-Balwierz A, Shanaida M, Biernat P, Baj T, Jasicka-Misiak I
Planta Med · 2025 Apr · PMID 39965645 · Publisher ↗
Green tea catechins are bioactive polyphenolic compounds that possess a number of biological activities and potential health benefits. This review will focus on discussing the effects of green tea catechins, with a parti...
Green tea catechins are bioactive polyphenolic compounds that possess a number of biological activities and potential health benefits. This review will focus on discussing the effects of green tea catechins, with a particular emphasis on clinical studies that evaluate their anticancer potential. Epigallocatechin gallate (EGCG), either as a stand-alone treatment or in conjunction with conventional anticancer therapies, represents a promising alternative strategy for the management of leukaemia. This review was based on a search of the scientific sources indexed in the databases PubMed and Scopus using the following keywords: '', 'tea catechins', 'anticancer', 'antioxidant', 'hematological cancer', and 'leukaemia' in combination. A deeper comprehension of the multifaceted mechanisms and findings of research could facilitate the development of novel strategies and the integration of green tea catechins into clinical practice, thus enhancing treatment outcomes for patients with leukaemia.
Possibility and Potenzial Intervention Targets of Saffron Extract in the Treatment of Atopic Dermatitis: A Review.
Shi H, Liu X, Zhao P … +6 more , Huang W, Wang H, Jin H, Zhu J, Wang J, Li T
Planta Med · 2025 May · PMID 39947646 · Publisher ↗
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disorder characterized by dry skin, eczema-like lesions, and severe itching. The multifaceted etiology of AD, which is not yet fully understood, includes g...
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disorder characterized by dry skin, eczema-like lesions, and severe itching. The multifaceted etiology of AD, which is not yet fully understood, includes genetic predispositions, immune dysfunctions(such as an impaired skin barrier and abnormal immune regulation), imbalances in the skin microbiota, and environmental factors, among others. In the field of AD treatment, the combination of traditional Chinese medicine and modern medicine is becoming an emerging trend. Given the potenzial side effects and reduced efficacy of conventional therapeutic drugs, Chinese herbal medicines offer patients new treatment options because of their unique efficacy and low toxicity. Some saffron extracts derived from saffron and gardenia, such as crocin, crocetin, and safranal, have shown promising potenzial in the treatment of AD. These natural ingredients not only possess anti-inflammatory and immunomodulatory properties similar to those of traditional Chinese medicines but also demonstrate excellent effects in promoting the repair of damaged skin barriers. Therefore, this article reviews the therapeutic potenzial of saffron extract in the treatment of AD, with a special focus on its mechanisms and potenzial interventions, while emphasizing the importance of herbal medicines as alternatives to traditional treatments, providing AD patients with safer and more effective treatment options.
Pseudopeptides of Marine Vibrio spp. from Taiwan and Their Combined Treatment Effects with Commercial Antibiotics.
Hong MX, Wang BW, Lo LH … +8 more , Jayalath GED, Lin WT, Yang YL, Tseng SP, Chen YH, Tsai WC, Cheng WC, Liaw CC
Planta Med · 2025 May · PMID 39933728 · Publisher ↗
strains, identified by 16S rDNA, were isolated from the marine environment surrounding Taiwan, revealing diverse bioactive effects, such as iron-chelating and antimicrobial activities. Notably, the hierarchical clusterin...
strains, identified by 16S rDNA, were isolated from the marine environment surrounding Taiwan, revealing diverse bioactive effects, such as iron-chelating and antimicrobial activities. Notably, the hierarchical clustering dendrogram of mass spectrum profiles of the strains using matrix-assisted laser desorption ionization time-of-flight, in contrast to the phylogenetic tree based on 16S rDNA sequencing analysis, exhibited a strong correlation with their observed bioactivities. Within this set, global natural products social molecular network analysis by LC-HRMS/MS highlighted that three strains, DJW05 - 1, DJW05 - 8, and DJW21 - 4, shared similar bioactive pseudopeptides in the same cluster. Subsequent chromatographical isolation and purification yielded an unprecedented unsaturated diketopiperazine, ()-3-(2-methylpropylidene)-2,3-dihydropyrrolo[1,2-]pyrazine-1,4-dione (1: ), along with a series of diketopiperazines, and a potential new annotated pseudopeptide (2: ), as well as three pseudopeptides, including andrimid (10: ), moiramide B (11: ), and moiramide C (12: ), and several alkaloids from DJW05 - 1. Further investigation into the combined applications of the major antimicrobial compound and commercial antibiotics revealed that andrimid (10: ) displayed significant inhibitory effects against gram-positive , and gram-negative , and , but not . Nevertheless, the potential for synergistic and additive effects of andrimid (10: ) with certain antibiotics remains, presenting valuable prospects for medicinal applications.
Real-World Data to Document the Use of Herbal Medicinal Products in Children - Report of a Workshop in Krakow.
Symma N, Hensel A, Roether B … +2 more , Steinhoff B, Bauer R
Planta Med · 2025 Apr · PMID 39933713 · Publisher ↗
The workshop "Real-world data to document the use of phytopharmaceuticals in children" was organized by the GA Foundation Plants for Health in collaboration with multiple international scientific societies on July 14, 20...
The workshop "Real-world data to document the use of phytopharmaceuticals in children" was organized by the GA Foundation Plants for Health in collaboration with multiple international scientific societies on July 14, 2024, during the International Congress on Natural Products Research in Kraków, Poland. The event focused on leveraging real-world data and real-world evidence to support the use of herbal medicinal products (syn. phytopharmaceuticals) in pediatric care. The workshop aimed to discuss the current state and future approaches for utilizing real-world data/real-world evidence in expanding the use of herbal medicinal products in children and adolescents. Therefore, the workshop highlighted the unmet needs and challenges in documenting the effectiveness and safety of herbal medicinal products in children and emphasized the coordinated exchange and collaboration among academia, industry, and regulatory authorities. After an e-symposium in May 2022 with more than 300 participants and an in-person workshop on this topic in Bonn in June 2023, this workshop in Krakow was the third event of its kind hosted by the Foundation Plants for Health. Participants concluded that interdisciplinary collaboration is highly needed to establish qualified methods of data collection and assessment of real-world data, e.g., establishing requirements to incorporate nonprescription herbal medicinal products into electronic patient records and registries that can be accessed by all stakeholders.
Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA.
Kemper L, Herrmann F, König S … +2 more , Falcone FH, Hensel A
Planta Med · 2025 Apr · PMID 39929245 · Publisher ↗
is the leading cause of severe enteritis worldwide. Identification of natural products against that inhibit early-stage host-pathogen interactions is a promising strategy, particularly by blocking bacterial adhesion to...
is the leading cause of severe enteritis worldwide. Identification of natural products against that inhibit early-stage host-pathogen interactions is a promising strategy, particularly by blocking bacterial adhesion to and invasion into the host cells. This should help to reduce the bacterial load in vector animals. From the seeds of , an aqueous extract (fenugreek high molecular fraction) of high-molecular compounds (polysaccharides, proteins) was obtained. The polysaccharide was characterized as galactomannan (1,4-mannose backbone, substituted at -6 with single galactose residues and galactose oligosaccharide chains). The protein part consisted of 50 kDa vicilin as the main compound. The fenugreek high molecular fraction did not influence proliferation of and viability of Caco-2 cells (1 - 1000 µg/mL). The fenugreek high molecular fraction reduced bacterial adhesion to Caco-2 significantly (500 - 1000 µg/mL), which was due to an interaction with the bacterial adhesin JlpA, preventing the interaction of this outer membrane protein to its ligand HSP90 (IC = 23.4 µg/mL). Bacterial invasion was reduced significantly. Both polysaccharides as well as vicilin contribute to the observed antiadhesive effect. As vicilin-like proteins are widely found in plants from the Fabaceae family, a vicilin-enriched protein preparation from was investigated for antiadhesive activity. These findings suggest that fenugreek seeds or vicilin-rich plant extracts could be used to develop novel strategies to control infections in food-producing animals, ultimately helping to decrease the prevalence of campylobacteriosis in humans.
The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs.
Zhu Y, Yu Y, Jia Y … +6 more , Lin Z, Lei J, Wu D, Xu T, Li L, Zheng B
Planta Med · 2025 Apr · PMID 39875131 · Publisher ↗
Herbal decoctions always contain numerous plant microRNAs, and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne pl...
Herbal decoctions always contain numerous plant microRNAs, and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne plant microRNAs are more likely to be absorbed. Thus, two antiviral herbal decoctions, Qingfei Paidu and Qingre Huashi Kangdu, were administered to human volunteers and rats, respectively, to investigate the characteristics of orally absorbed decoction-borne plant microRNAs. MIR-6240 - 3 p was identified as an absorbed plant microRNA in humans and is most highly expressed in Qingfei Paidu decoction. Therefore, the kinetics of MIR-6240 - 3 p were monitored in humans following the administration of the Qingfei Paidu decoction, and its antiviral effect on human coronavirus type 229E (HCoV-229E) was examined . There were 586 176 small RNAs identified in Qingfei Paidu decoction, of which 100 276 were orally absorbed by humans. In the Qingre Huashi Kangdu decoction, 124 026 small RNAs were detected, with 7484 being orally absorbed by rats. Logistical repression analysis revealed that absorbable plant small RNAs in both humans and rats presented higher expression levels, greater minimum free energy, and increased AU/UA frequencies compared to nonabsorbable plant small RNAs. The amount of MIR-6240 - 3 p in humans increased between 1 and 3 h after the administration of the Qingfei Paidu decoction. In addition, MIR-6240 - 3 p significantly reduced the RNA copy number and TCID of HCoV-229E . These results suggest that herbal decoction-borne plant small RNAs with a higher expression level, greater minimum free energy, or an increased AU/UA frequency are more likely to be orally absorbed and could potentially mediate cross-kingdom gene regulation.
Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp.
Fajardo-Hernández CA, Zavala-Sierra ÁG, Merlin-Lucas VI … +2 more , Morales-Jiménez JI, Rivera-Chávez J
Planta Med · 2025 Apr · PMID 39870085 · Publisher ↗
An approach combining enzymatic inhibition and untargeted metabolomics through molecular networking was employed to search for human recombinant full-length protein tyrosine phosphatase 1B (PTP1 B) inhibitors from a coll...
An approach combining enzymatic inhibition and untargeted metabolomics through molecular networking was employed to search for human recombinant full-length protein tyrosine phosphatase 1B (PTP1 B) inhibitors from a collection of 66 mangrove-associated fungal taxa. This strategy prioritized two strains (IQ-1612, section , and IQ-1620, section ) for further studies. Chemical investigation of strain IQ-1612 resulted in the isolation of a new nonanolide derivative, roseoglobuloside A (1: ), along with two known metabolites (2: and 3: ), whereas strain IQ-1620 led to the isolation of four known naphtho-γ-pyrones and one known diketopiperazine (4: -8: ). Of all isolates, compounds 2, 3: , and 7: showed a marked inhibitory effect on PTP1B with an IC value < 20 µM, while 6: showed moderate inhibition with IC of 65 µM. Compounds 1: and 8: were inactive at a concentration of 100 µM, whereas 4: and 5: demonstrated significant inhibition at 20 µM. The structure of 1: was established by comprehensive spectroscopic analysis, and its relative and absolute configuration was assigned based on NOE correlations and by comparison of calculated and experimental ECD curves. Molecular docking indicated that these molecules primarily bind to two different allosteric sites, thereby inducing conformational changes that impact enzymatic activity.
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