Schizophr Res
· 2026 Jan · PMID 41240457
·
Publisher ↗
BACKGROUND: The role of peripheral glutamate as an accessible biomarker for schizophrenia remains unclear. Its potential to reflect illness progression or differentiate treatment-resistant (TRS) from non-resistant (non-T...BACKGROUND: The role of peripheral glutamate as an accessible biomarker for schizophrenia remains unclear. Its potential to reflect illness progression or differentiate treatment-resistant (TRS) from non-resistant (non-TRS) patients, and its relationship with central glutamate, require further investigation. This exploratory study assessed plasma glutamate levels and their associations with anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) glutamate in both TRS and non-TRS patients. Additionally, we examined associations between plasma glutamate and clinical characteristics, including psychiatric and cognitive measures. METHODS: We examined 71 patients (33 non-TRS, 38 TRS). Plasma glutamate was measured using colorimetry, and ACC and mPFC glutamate were assessed via Magnetic Resonance Spectroscopy (MRS). RESULTS: Plasma glutamate levels were significantly higher in non-TRS compared to TRS patients. However, there was no significant correlation between plasma glutamate and ACC or mPFC glutamate in either group. Furthermore, plasma glutamate was not associated with clinical measures, including Positive and Negative Syndrome Scale (PANSS) scores, aggression scores, general scores, or the working memory index. CONCLUSION: There is preliminary evidence that peripheral glutamate levels are lower in TRS compared to non-TRS patients; however, peripheral glutamate does not appear to reliably reflect brain glutamate levels or symptom severity in schizophrenia.
Buck B, Whiting E, Hallgren K
… +2 more, Monroe-DeVita M, Ben-Zeev D
Schizophr Res
· 2025 Dec · PMID 41218355
·
Full text
Caregiver involvement is critical to outcomes for young people with early psychosis. Caregiver-focused interventions reduce caregiver distress, improve family communication, and increase likelihood of recovery, but many...Caregiver involvement is critical to outcomes for young people with early psychosis. Caregiver-focused interventions reduce caregiver distress, improve family communication, and increase likelihood of recovery, but many caregivers face barriers to access. Because mHealth interventions can be accessed remotely and require minimal staffing, they could address some of these challenges. Our team conducted a pilot trial of Bolster, an mHealth intervention for early psychosis caregivers, with sixty (N = 60) caregivers to young adults with early psychosis to determine the acceptability and preliminary efficacy of Bolster as well as the feasibility of this approach. Participants were randomized to receive (1) a list of extant online resources (control arm), or (2) these resources alongside the Bolster mobile app (intervention arm). Caregivers used Bolster frequently (30.2 % of days during the intervention period and 10.4 min per use day) and reported finding it usable and helpful in supporting their caregiving activities. Outcome analyses demonstrated improvements in multiple outcomes, including family communication (Cohen's d = 0.86) and caregiver psychological morbidity (d = 0.98). Improvements in the Bolster arm were larger than control for caregiver psychological morbidity (d = 0.61) and distress related to the loved one's illness (d = 0.72), and caregivers in the Bolster arm were more likely to report that their loved one accessed psychotherapy or counseling (aRR = 2.53 [95 % CI: 1.07 to 6.01]) and met with a medication provider (aRR = 2.91 [95 % CI: 1.10 to 7.65]). Results suggest that Bolster is acceptable to caregivers and has promising preliminary efficacy.
Bart TA, Hricovec MM, Taylor S
… +2 more, Amlong W, Cicero DC
Schizophr Res
· 2025 Dec · PMID 41202752
·
Publisher ↗
Paranoid ideation relates to a mistrust or suspicion of other people and their motives and may be especially influenced by environmental and psychosocial factors. Historically marginalized populations consistently endors...Paranoid ideation relates to a mistrust or suspicion of other people and their motives and may be especially influenced by environmental and psychosocial factors. Historically marginalized populations consistently endorse higher levels of paranoid ideation than Non-Hispanic White individuals, but it is unclear whether these differences can be attributed to measurement bias or if they represent genuine between-group differences in the latent construct. The current study aimed to examine the measurement invariance of five common paranoia measures. Participants included Non-Hispanic White (n = 308), Black American (n = 299), and Hispanic (n = 281) groups recruited from the general population. Scales included the Revised-Green Paranoid Thoughts Scale (R-GPTS), Paranoia Scale (PS), Persecution and Deservedness Scale (PaDS), Paranoia/Suspiciousness Questionnaire (PSQ), and the Personality Inventory for the DSM-5 (PID-5) Suspiciousness facet scale. Measurement invariance analyses indicated the R-GPTS, PS, PaDS, PID-5 Suspiciousness facet, and PSQ Negative Mood/Withdrawal and Perceived Hardship/Resentment subscales showed configural, metric, and scalar invariance, while the Interpersonal Suspiciousness/Hostility and Mistrust/Wariness subscales lacked scalar invariance. Black American participants had higher mean scores on all invariant measures, followed by Hispanic and Non-Hispanic White participants. For the scales that displayed scalar invariance, these results are unlikely to be attributable to measurement bias, and instead likely reflect cultural and potentially adaptive responses to the complex relationships between cultural, social, and economic factors. To better understand how demographic variables and social determinants of health may influence paranoid ideation in diverse populations, future research should incorporate these variables into measurement invariance and group difference analyses.
Wang YC, Fan HY, Huang QH
… +9 more, Liu XC, Huang YR, Su Z, Cheung T, Ungvari GS, Feng Y, Wang G, Ng CH, Xiang YT
Schizophr Res
· 2025 Dec · PMID 41197176
·
Publisher ↗
BACKGROUND: Although numerous studies have examined the impact of schizophrenia on quality of life (QoL), the results have been mixed. This meta-analysis compared QoL across various domains between schizophrenia patients...BACKGROUND: Although numerous studies have examined the impact of schizophrenia on quality of life (QoL), the results have been mixed. This meta-analysis compared QoL across various domains between schizophrenia patients and healthy controls and identified the moderators of group differences. METHODS: A meta-analysis of case-control studies was conducted following PRISMA guidelines. Major international databases (PubMed, Web of Science, EMBASE and PsycINFO) and Chinese databases (CNKI and Wanfang) were searched from their inception to December 2024. Studies comparing QoL between patients with schizophrenia and healthy controls using standardized validated instruments (e.g., WHOQOL, SF-36) were included. Standardized mean differences (SMDs) were calculated using a random-effects model. Subgroup and meta-regression analyses were performed to explore the moderators of group differences. RESULTS: Thirty-six studies (5664 patients; 5042 controls) met the inclusion criteria, revealing significant QoL impairment in patients across all domains. Deficits were most pronounced in the physical domain (WHOQOL: SMD = -1.52; SF-36: SMD = -1.16; GQOLI: SMD = -2.38) and social domain (WHOQOL: SMD = -1.33; SF-36: SMD = -1.24; GQOLI: SMD = -2.56), with notable impairment also in psychological (WHOQOL: SMD = -1.11) and environmental (WHOQOL: SMD = -0.87) domains. Meta-regression demonstrated that more severe negative symptoms score (β = -0.051, p = 0.043) and greater general psychopathology (β = -0.038, p = 0.049) were significantly associated with poorer environmental QoL. CONCLUSION: This meta-analysis demonstrated that patients with schizophrenia have significant QoL impairment across multiple domains, particularly in the physical and social functioning domains. These findings highlight the need to address clinical moderators to develop patient-centered interventions.
Schizophr Res
· 2025 Dec · PMID 41192376
·
Publisher ↗
Schizophrenia is a complex neurodevelopmental disorder characterized by widespread cognitive and behavioral impairments, with the hippocampus playing a critical role in its pathophysiology. While traditional approaches s...Schizophrenia is a complex neurodevelopmental disorder characterized by widespread cognitive and behavioral impairments, with the hippocampus playing a critical role in its pathophysiology. While traditional approaches such as animal models and postmortem studies have provided valuable insights, they fall short in capturing the human-specific and developmental features of the disease. Human pluripotent stem cell (hPSC) models, particularly 3D brain organoids, represent a powerful new tool for investigating the cellular and circuit-level mechanisms underlying schizophrenia. Although cortical and striatal organoids have been increasingly utilized in psychiatric research, hippocampal organoid models remain underdeveloped and underused. This review outlines the developmental basis of hippocampal dysfunction in schizophrenia and discusses the emergence of hPSC-derived hippocampal organoids and assembloids as novel in vitro systems. We highlight key findings from the limited studies using hippocampal differentiations in schizophrenia, explore their potential to model region-specific circuitry (e.g., DG-CA3, cortico-hippocampal, and hippocampalstriatal networks), and identify major technical challenges such as the absence of CA1/CA2 subfields, limited vascularization, and the need for microglial integration. Finally, we propose future directions to refine these models and leverage them for mechanistic discovery and therapeutic screening. By integrating genetic, imaging, and developmental perspectives, this review positions hippocampal organoid technology as a promising yet underutilized platform for advancing our understanding of schizophrenia's neurodevelopmental origins.
Wang K, Sun Y, Xia C
… +4 more, Yang X, Liang H, Hu N, Lui S
Schizophr Res
· 2025 Dec · PMID 41135368
·
Publisher ↗
BACKGROUND: Subfield-specific microstructural alterations of the hippocampus and their clinical relevance remain poorly characterized. This study investigated hippocampal subfield-specific microstructural alterations in...BACKGROUND: Subfield-specific microstructural alterations of the hippocampus and their clinical relevance remain poorly characterized. This study investigated hippocampal subfield-specific microstructural alterations in schizophrenia (SCZ) patients using high-resolution diffusion tensor imaging (DTI). METHODS: Forty-six SCZ patients and 55 healthy controls underwent 3.0 T MRI scanning using high-resolution T1-weighted imaging and DTI (0.9-mm isotropic resolution), which was employed to quantify volumes and microstructural integrity across hippocampal subfields, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Volumetric and DTI metrics were compared and correlated with clinical features. RESULTS: Key findings revealed significant microstructural changes in nine of 16 hippocampal subfields in patients. The predominant pattern featured increased MD, AD, and RD, alongside heterogeneous FA; however, a minority of subfields exhibited divergent trends (F = 6.19-19.38, P ≤0.001-0.03). Subfield-specific volume reductions were not statistically significant after correction. Notably, CA2/3 exhibited robust diffusivity alterations, significantly correlated with semantic fluency scores (r = -0.35 - -0.34, P = 0.04). CONCLUSIONS: These results underscored the subfield-specific hippocampal pathology in SCZ and imply that microstructural compromise reflected in DTI parameters may offer greater sensitivity than volumetric changes and precede macroscopic atrophy. Critically, hippocampal microstructural alterations, especially in CA2/3, may be associated with specific cognitive deficits in SCZ.
Myers EJ, Lysaker PH, Rand KL
… +3 more, Salyers MP, Bonfils KA, Minor KS
Schizophr Res
· 2025 Dec · PMID 41135367
·
Full text
Disorganized speech can disrupt effective communication in schizophrenia-spectrum disorders (SSDs). Recent work has tied disorganized speech to deficits in metacognitive capacity, or one's capacity to integrate experienc...Disorganized speech can disrupt effective communication in schizophrenia-spectrum disorders (SSDs). Recent work has tied disorganized speech to deficits in metacognitive capacity, or one's capacity to integrate experiences to form complex mental representations. Specifically, recent work has shown that metacognitive deficits may emerge only at higher levels of disorganized speech, suggesting a possible exponential relationship. The present study investigated this relationship in a large sample of 485 adult outpatients with SSDs. We aimed to: 1) broadly characterize the nature of the relationship between metacognitive capacity and disorganized speech; and 2) compare metacognitive capacity across levels of conceptual disorganization. We employed ANOVAs, Tukey's HSD post hoc tests, and curve estimation analyses to answer these questions. Results provide mixed evidence that the relationship between metacognitive capacity and conceptual disorganization is exponential. Critically, we found that as levels of conceptual disorganization increase, there are small, clinically relevant decreases in metacognitive capacity, especially in metacognitive mastery. These findings have clinical implications for tailoring metacognitive interventions for patients with high levels of disorganized speech. Our results highlight the need for including participants with extreme disorganized speech and using multidimensional measures of disorganized speech in future studies.
Xavier G, Ota V, Kajitani GS
… +13 more, Mauer JH, Asprino PF, Costa GO, Cavalcante DA, Cerqueira R, Novaes A, Dos Santos FR, Gadelha A, Noto C, Boim MA, Galante PAF, Santoro ML, Belangero SI
Schizophr Res
· 2025 Dec · PMID 41125054
·
Publisher ↗
First-episode psychosis (FEP) represents a critical period characterized by severe psychotic symptoms, where early intervention is vital. Identifying objective biomarkers to assess symptoms and guide treatment remains a...First-episode psychosis (FEP) represents a critical period characterized by severe psychotic symptoms, where early intervention is vital. Identifying objective biomarkers to assess symptoms and guide treatment remains a significant challenge. Extracellular vesicles (EVs), particularly their microRNAs (miRNAs), emerge as promising candidates due to their ability to cross the blood-brain barrier and modulate gene expression. Since antipsychotic medications can influence miRNA expression, studying antipsychotic-naïve FEP patients is crucial for isolating disease-specific changes. This study analyzed miRNA expression in serum EVs from 12 antipsychotic-naïve FEP patients, before and after two months of risperidone treatment, comparing results to 12 healthy controls. Next-generation sequencing (NGS) identified 613 miRNAs in total; after filtering out low-expressed transcripts, 428 miRNAs were retained for differential expression analysis. Two miRNAs-miR-335-5p and miR-30d-5p presented reduced expression in FEP patients compared to controls. This reduction persisted after treatment but showed signs of attenuation. Notably, miR-30d-5p expression was negatively correlated with depressive symptoms assessed via the Calgary Depression Scale for Schizophrenia. Additionally, miR-744-5p was upregulated following risperidone treatment, suggesting a potential modulatory effect of the drug on EV miRNA expression. Both miR-30d-5p and miR-744-5p have been previously implicated in mental disorders, neurodevelopment, and schizophrenia-related pathways, with confirmed expression in neurons. Here we also observed that predicted targets from these miRNAs are involved in synaptic related pathways. Although limited by the small sample size, our findings propose novel avenues for psychosis research and biomarker discovery.
Schizophr Res
· 2025 Dec · PMID 41118689
·
Publisher ↗
Schizophrenia (SCZ) is a neurodevelopmental psychiatric disorder that typically emerges in late adolescence or early adulthood. In rats, administration of the DNA-alkylating agent methylazoxymethanol acetate (MAM) on ges...Schizophrenia (SCZ) is a neurodevelopmental psychiatric disorder that typically emerges in late adolescence or early adulthood. In rats, administration of the DNA-alkylating agent methylazoxymethanol acetate (MAM) on gestational day (GD) 17 induces several features resembling those observed in SCZ patients. Preclinical and clinical studies suggest that cannabidiol (CBD) has antipsychotic-like effects. Here, we evaluated whether acute CBD treatment attenuates behavioral deficits and the enhanced dopamine (DA) system activity in the ventral tegmental area (VTA) of adult male and female MAM rats. Pregnant rats received saline or MAM (20 mg/kg) on GD17. In adulthood, offspring were tested in the elevated plus-maze (EPM), novel object recognition (NOR) test, and locomotor responses to the NMDA receptor antagonist MK-801. The in vivo electrophysiological activity of VTA DA neurons was also recorded. CBD (60 mg/kg) was administered 1 h before each behavioral test and electrophysiological recording. Male and female MAM rats exhibited anxiety-like behavior in the EPM, which was not reversed by CBD. In the NOR test, CBD reversed memory impairment in male MAM rats, whereas female MAM rats showed no deficits. Neither male nor female MAM rats exhibited increased locomotor responses to MK-801, and CBD did not affect this behavior. Both male and female MAM rats showed increased VTA DA neuron population activity, which was reversed by CBD in both sexes. Our findings indicate that CBD attenuates cognitive deficits and enhanced DA system activity in the MAM model, supporting the hypothesis that CBD produces antipsychotic-like effects.
Camon E, Masier S, Mota NB
… +1 more, D'Agostino A
Schizophr Res
· 2025 Dec · PMID 41118688
·
Publisher ↗
Language disorganization is a hallmark of psychosis which has traditionally been assessed through clinical interviews and standardized scales. Recent advances in Natural Language Processing (NLP) and graph theory provide...Language disorganization is a hallmark of psychosis which has traditionally been assessed through clinical interviews and standardized scales. Recent advances in Natural Language Processing (NLP) and graph theory provide innovative, objective methodologies to analyze language production in psychosis. In particular, dream reports, as a unique form of narrative, offer a valuable lens through which to examine the presence of disorganized linguistic features. This study analyzed structural speech graphs of written and oral dream reports from 193 Italian participants (115 individuals with acute psychosis and 78 healthy controls), focusing on key connectivity attributes, such as the Largest Connected Component (LCC), the Largest Strongly Connected Component (LSC) and their z-scores relative to random graph distributions. Patients with psychosis exhibited significantly lower connectivity values than controls (p < 0.0125), with their speech graphs resembling random word sequences more frequently. These results remained significant after controlling for education (p < 0.05), with LCC and LSCz surviving Bonferroni correction (p < 0.0125). A Naïve Bayes classifier using these features achieved 68 % accuracy (AUC = 0.75), demonstrating the potential for automated classification of psychosis. To our knowledge, this is the first study conducted with native Italian speakers, reinforcing the cross-linguistic validity of graph-based approaches. Also, our findings support the utility of graph analysis in detecting psychosis and reinforce the notion that speech abnormalities can be captured from a topological perspective through reductions in speech connectedness, thereby providing a novel framework for understanding thought and language impairments associated with the disorder.
Thompson AJ, Marie R, Tonge B
… +2 more, Pantelis C, Wannan CMJ
Schizophr Res
· 2025 Dec · PMID 41118687
·
Publisher ↗
BACKGROUND: Psychotic-Like Experiences (PLEs) during early adolescence may precede development of later psychotic disorders. Given evidence of environmental challenges contributing to the psychotic disorder psychopatholo...BACKGROUND: Psychotic-Like Experiences (PLEs) during early adolescence may precede development of later psychotic disorders. Given evidence of environmental challenges contributing to the psychotic disorder psychopathology, this study examined if child temperament mediates the association between the family environment and PLEs. METHODS: Data from the Adolescent Brain Cognitive Development study (ABCD) was used. The family environment was taken from the baseline reading, with temperament and PLEs taken from 2-year follow-up. Three family environment variables (parental monitoring, parental acceptance, and family conflict) and four temperament variables (executive control, negative affect, asociality and focused attention) were used. A Structural Equation Model (SEM) was created to assess the mediation of temperament between family environment and PLEs. RESULTS: SEM analysis showed that Executive Control and Focused Attention partially mediated the relationship between family environment and PLEs. Higher parental monitoring and acceptance were associated with better executive control and focused attention, which in turn corresponded with fewer distressing PLEs. All family environment variables also had significant direct effects on distressing PLEs. CONCLUSIONS: These findings suggest that child temperament, particularly executive control and focused attention, may mediate the effects of family environment on PLEs. Although causality cannot be inferred, supportive family environments appear to enhance executive control and attention, potentially reducing PLE risk during early adolescence. Direct effects of the family environment on PLEs also emphasize the importance of family functioning in adolescent mental health. Interventions aimed at improving family dynamics and supporting development of positive temperament traits may help mitigate the risk of PLEs.
Schizophr Res
· 2025 Dec · PMID 41118686
·
Publisher ↗
Schizophrenia imposes a global health burden characterized by treatment-refractory cognitive deficits, with converging evidence implicating cerebellar-cortical circuit dysfunction as a pivotal pathophysiological mechanis...Schizophrenia imposes a global health burden characterized by treatment-refractory cognitive deficits, with converging evidence implicating cerebellar-cortical circuit dysfunction as a pivotal pathophysiological mechanism. In this review, we focus on the advances from neuroimaging, molecular, and therapeutic studies to elucidate the cerebellum's role in schizophrenia-related cognitive pathology. Particularly, we aim to address the advances across four domains: cognitive subtyping in schizophrenia; cerebellar-cortical connectivity evidenced from anatomical, lesion, and neuroimaging studies; multiscale neuropathology in molecular, cellular, and structural alterations; and emerging therapeutics targeting cerebellar nodes through pharmacological, neuromodulatory, and molecular approaches. Collectively, this work supports the cerebellum's role as a critical hub involved in cognitive pathology of schizophrenia.
Kwok SYCL, Li Y, Chu MH
… +2 more, Singh H, Fang S
Schizophr Res
· 2025 Dec · PMID 41110249
·
Publisher ↗
OBJECTIVE: This study evaluated the effectiveness of an enhanced WELLFOCUS Positive Psychotherapy intervention (EWPPT) on the well-being, recovery, and quality of life of people with schizophrenia (PWS) in halfway houses...OBJECTIVE: This study evaluated the effectiveness of an enhanced WELLFOCUS Positive Psychotherapy intervention (EWPPT) on the well-being, recovery, and quality of life of people with schizophrenia (PWS) in halfway houses in Hong Kong. METHODS: A single-blind, randomised controlled trial was conducted in 10 halfway houses. The participants (N = 111) were randomly assigned to an intervention group (N = 56, 60.7 % female) or a control group (N = 55, 47.3 % female). The intervention group participated in an 18-week group EWPPT in addition to standard care, while the control group received only standard care. A set of validated questionnaires was administered to assess their well-being, recovery, and quality of life at baseline, post-intervention, and three-month follow-up. Semi-structured interviews with 8 participants provided qualitative insights into their experiences. RESULTS: Repeated measures analyses of variance and post-hoc tests revealed significant improvements in well-being (Cohen's d = .47-.48, p < .01) and recovery (d = .40-.52, p < .001) over time in the intervention group. Quality of life (d = .32, p = .043) showed a smaller but significant improvement at the three-month follow-up. The intervention group also reported significantly higher well-being scores at follow-up (d = .41, p = .024). The qualitative results highlighted personal growth in relationship building, recognition of character strengths, and a renewed sense of self. CONCLUSIONS: These findings support the effectiveness of the EWPPT intervention in promoting the well-being and recovery of PWS in halfway houses. Further refinement and long-term studies are recommended to optimise its impact.
Tabata K, Toriumi K, Suzuki K
… +13 more, Takagi H, Parida IS, Niizato K, Oshima K, Imai A, Nagase Y, Hashimoto R, Yamasaki S, Nishida A, Itokawa M, Takahashi H, Miyashita M, Arai M
Schizophr Res
· 2025 Dec · PMID 41108879
·
Publisher ↗
Schizophrenia (SCZ) is a heterogeneous mental disorder with a complex and multifaceted pathophysiology. Current antipsychotic medications based on the hyperdopaminergic hypothesis, fail to achieve adequate symptom improv...Schizophrenia (SCZ) is a heterogeneous mental disorder with a complex and multifaceted pathophysiology. Current antipsychotic medications based on the hyperdopaminergic hypothesis, fail to achieve adequate symptom improvement in approximately 30 % of patients, indicating the need for novel treatment strategies grounded on homogenous pathophysiology defined by specific biomarkers. Accumulating evidence indicates the presence of zinc (Zn) deficiency in a subpopulation of individuals with SCZ, although its role in SCZ pathophysiology remains underexplored. In this study, we aimed to characterize the clinical features associated with hypozincemia in SCZ to identify a homogeneous subgroup that may benefit from tailored-made treatment with Zn supplementation. A cohort of 497 individuals with SCZ or schizoaffective disorder was classified into hypozincemia (<80.0 μg/dL) and non-hypozincemia groups. Between-group differences in clinical features were examined, and regression analysis was performed to determine the association between serum Zn levels and positive and negative syndrome scale (PANSS) scores. Hypozincemia was diagnosed in 68.0 % of the study participants. The hypozincemia group was characterized by older age, longer disease duration, more frequent hospitalizations, and higher PANSS scores compared with the non-hypozincemia group. After adjusting for age, hospitalization, and antipsychotic medication use, regression analysis demonstrated a significant negative correlation between serum Zn levels and the positive symptom subscale, general psychopathology subscale, and total score. These findings may enhance the understanding of the mechanisms underlying the clinical severity of SCZ and support the potential use of Zn supplementation to mitigate neuropsychiatric symptoms in patients with hypozincemia.
Gonzales L, Saperstein A, Erlich M
… +1 more, Medalia A
Schizophr Res
· 2025 Dec · PMID 41108878
·
Publisher ↗
Cognitive impairment is a core feature of schizophrenia, affecting over 80% of diagnosed people and negatively impacting their daily lives. Recent research has identified stigma toward the cognitive impairment associated...Cognitive impairment is a core feature of schizophrenia, affecting over 80% of diagnosed people and negatively impacting their daily lives. Recent research has identified stigma toward the cognitive impairment associated with schizophrenia, highlighting how changes in sense of self and perception interact with cognition to shape daily interactions and functioning. This scoping review sought to provide an overview of the published research linking stigma and cognition in psychotic disorders, in order to identify gaps in knowledge and directions for future research. The review followed PRISMA-ScR guidelines across PubMed, Web of Science, and PsycInfo databases. A total of 32 papers were eligible and reviewed for data extraction including study design, sample characteristics, and main findings reported. A total of 20 papers evaluated relationships between stigma and neurocognition, while 12 focused on social cognition or metacognition as related to stigma. The vast majority of papers (over 80%) focused on internalized stigma as related to cognition. This current literature suggests that subjective cognition, rather than performance-based cognition, is of importance for internalized stigma among people with psychotic disorders. Additional research is needed regarding how other stigma constructs, such as perceived stigma experiences or stigma specific to cognitive difficulties, may be associated with cognition and functional outcomes.