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Journal Of The American Academy Of Dermatology[JOURNAL]

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Hypoactive Sexual Desire Disorder in Menopausal Women: Dermatologic Implications of Antiandrogen and Testosterone Therapy.

Mauskar MM, Marmon S

J Am Acad Dermatol · 2026 Jul · PMID 42401263 · Publisher ↗

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Incise parallel, section perpendicular to the dermatoglyphs for diagnosis of acral melanocytic lesions-A comment on Thakker et al.

Phelan PS, Shalin SC

J Am Acad Dermatol · 2026 Jul · PMID 42401262 · Publisher ↗

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Response to Xue et al, "Defining super-responders is not the same as predicting rituximab response in pemphigus".

Wu Z, Jiang J, Duan K … +4 more , Li G, Guo F, Zhang J, Xue R

J Am Acad Dermatol · 2026 Jul · PMID 42401261 · Publisher ↗

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Defining super-responders is not the same as predicting rituximab response in pemphigus.

Xue Y, Yan J

J Am Acad Dermatol · 2026 Jul · PMID 42401259 · Publisher ↗

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Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

Riller Q, Azoyan L, Garrault L … +18 more , Dousset L, Zuelgaray E, Mary-Prey S, Zehou O, Templier C, Guicheney M, Chasset F, Bolko L, Bourgault-Villada I, Roguedas-Contios AM, Lesort C, Viguier M, Sène D, Battistella M, Bouaziz JD, Lebbe C, Mahévas T, Eosinophilic Fasciitis study group

J Am Acad Dermatol · 2026 Jul · PMID 42401258 · Publisher ↗

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Re: Effect of anatomical site on prognosis and progression pattern in early-stage acral melanoma: A retrospective cohort study of 281 cases.

Tooba F, Khan AM, Talha M … +2 more , Shah SA, Hasan AH

J Am Acad Dermatol · 2026 Jul · PMID 42401257 · Publisher ↗

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Adjuvant radiation therapy is not associated with improved survival in low-risk localized Merkel cell carcinoma: an Analysis of the National Cancer Database.

Kasheri E, Zumsteg ZS, Kodumudi V … +2 more , Gharavi N, Rosenthal A

J Am Acad Dermatol · 2026 Jul · PMID 42401256 · Publisher ↗

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Sexual function is missing from the adverse-effect map of GLP-1 receptor agonists in dermatology.

Grimolizzi F

J Am Acad Dermatol · 2026 Jul · PMID 42398782 · Publisher ↗

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Safety of Biologic Therapy in Psoriasis Patients With Malignancy.

Lin L, Ho CK, Wu G

J Am Acad Dermatol · 2026 Jul · PMID 42398780 · Publisher ↗

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Letter from the Editor: Glucagon-Like Peptide-1 (GLP-1) agonists in dermatology.

Elston DM

J Am Acad Dermatol · 2026 Jul · PMID 42398779 · Publisher ↗

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Rethinking the Occipital Scalp as a Control in Advanced Androgenetic Alopecia.

Maas D, Spindler A, Zappi I … +2 more , Shapiro J, Lo Sicco KI

J Am Acad Dermatol · 2026 Jul · PMID 42398778 · Publisher ↗

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Parallel-Polarized Dermoscopy for Acral Parallel Pattern Analysis.

Yurekli A, Simsek G

J Am Acad Dermatol · 2026 Jul · PMID 42398777 · Publisher ↗

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Retinal Abnormalities in Alopecia Areata: A Systematic Review and Meta-Analysis.

Ameri K, Ashamalla M, Shunmugam M … +2 more , Kipfer S, Donovan J

J Am Acad Dermatol · 2026 Jul · PMID 42398776 · Publisher ↗

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Remote shutter release for improving image quality in smartphone-mounted super high magnification photo and videodermoscopy.

Kaliyadan F, Suresh S, Pietkiewicz P

J Am Acad Dermatol · 2026 Jul · PMID 42398775 · Publisher ↗

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Interpreting Radiographic Outcomes Across IL-23 Inhibitor Trials in Psoriatic Arthritis: The Role of Trial Design.

Oberlin D, Veenstra J

J Am Acad Dermatol · 2026 Jul · PMID 42398773 · Publisher ↗

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Comparative Alopecia Outcomes After Copper and Hormonal Intrauterine Device Placement: A TriNetX Database Retrospective Cohort Study.

Maas D, Zaminski D, Spindler A … +7 more , Adler R, Kozlov M, Zappi I, Pomeranz MK, Bieber AK, Shapiro J, Lo Sicco KI

J Am Acad Dermatol · 2026 Jul · PMID 42392459 · Publisher ↗

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Uncovering a Dual Th17/Type 2 Transcriptomic Endotype in Psoriasis.

Chen CH, Lee MS, Chang WY … +7 more , Cho YT, Lu YT, Huang WL, Chu CY, Tsai TF, Krueger JG, Chan TC

J Am Acad Dermatol · 2026 Jul · PMID 42392458 · Publisher ↗

BACKGROUND: The IL-23/Th17 axis is the cornerstone of psoriasis pathogenesis, but molecular heterogeneity across different ethnicities remains poorly defined. OBJECTIVE: To comprehensively define the immunological and pa... BACKGROUND: The IL-23/Th17 axis is the cornerstone of psoriasis pathogenesis, but molecular heterogeneity across different ethnicities remains poorly defined. OBJECTIVE: To comprehensively define the immunological and pathogenic transcriptomic profiles of a Taiwanese psoriasis cohort. METHODS: Lesional skin (LS) and non-lesional skin (NL) biopsies from 11 patients with chronic plaque psoriasis and normal skin (N) from 9 healthy controls were analyzed via bulk RNA-sequencing. Differential gene expression (DEG), pathway enrichment (GSEA), and clinical correlations (PASI score) were performed. Serum levels of cytokines were validated via ELISA from all 50 psoriasis patients and 9 healthy controls. RESULTS: Analysis identified 4,694 DEGs in LS vs. N. We confirmed robust Th17 upregulation (IL-17A/C, IL-23A). Unanticipatedly, a profound dual immune dysregulation was identified, involving significant upregulation of Type 2 (Th2) signatures (IL-4R, CCL17, TSLP). The IL-36 family was the most highly activated cytokine axis (IL-36G log2FCH=5.5). Barrier function genes (KRT77, GJB4) were significantly downregulated. Correlation analysis identified IL-36RN and the combination of AREG/CDSN (r ≈ -0.9, p=0.002) as potential severity biomarkers. LIMITATIONS: The small sample size and focus on a single ethnic group. Transcriptomic findings represent associations rather than mechanistic evidence of pathogenesis. CONCLUSION: Taiwanese psoriasis is characterized by a dual Th17/Type 2 endotype and extreme IL-36 activation. This molecular landscape underscores the need for stratified therapeutic strategies in Taiwanese populations.
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