Journal Of The American Academy Of Dermatology[JOURNAL]

BACKGROUND: Condyloma lata is a manifestation of secondary syphilis that is underrecognized histopathologically, reported to mimic other entities, including squamous cell carcinoma. OBJECTIVE: To describe characteristic... BACKGROUND: Condyloma lata is a manifestation of secondary syphilis that is underrecognized histopathologically, reported to mimic other entities, including squamous cell carcinoma. OBJECTIVE: To describe characteristic clinical and histopathologic features of condyloma lata. METHOD: A retrospective review was conducted of cases with histopathologic diagnoses of syphilis from January 2010 to February 12, 2025. The histopathologic findings were categorized as condyloma lata or other manifestations of secondary syphilis. RESULT: Of 28 syphilis cases, 12 patients (15 specimens) were diagnosed with condyloma lata. The average age was 36.8 years (range: 21-52), with an equal sex distribution. Twelve of 15 lesions were anogenital, and 3 were extragenital. Syphilis was included in the clinical diagnosis in only 50% of cases, and one oral lesion was initially misdiagnosed as squamous cell carcinoma. In 25% (3/12) of the cases, the patient had other cutaneous manifestations of secondary syphilis. All condyloma lata lesions showed a consistent constellation of findings such as follows: eroded dome-shaped or verrucous plaque with bulbous, jagged, and/or irregular pseudoepitheliomatous hyperplasia, a dense or lichenoid lymphoplasmacytic infiltrate, prominent neutrophilic exocytosis associated with small spongiotic vesicles, and numerous spirochetes concentrated in the lower third of the epidermis. The remaining 16 patients (19 specimens) with noncondyloma lata secondary syphilis demonstrated considerable histopathologic variability. LIMITATION: Retrospective design with a small sample size. CONCLUSION: Condyloma lata exhibits consistent, reliable, reproducible histopathologic features. Recognition of these features can prevent misdiagnosis, particularly at extragenital sites, where syphilis may be clinically unsuspected.

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Anhidrosis: An underappreciated factor in dermatologic diseases.

Lutz GF, Davis MDP, Sandroni P … +2 more , Coon EA, Sartori Valinotti JC

J Am Acad Dermatol · 2026 Jun · PMID 42246918 · Publisher ↗

Dissipation of body heat, essential to human life, is largely achieved through sweating. If sweating does not occur normally-as in patients with hypohidrosis (reduced sweating) or anhidrosis (lack of sweating)-the abilit... Dissipation of body heat, essential to human life, is largely achieved through sweating. If sweating does not occur normally-as in patients with hypohidrosis (reduced sweating) or anhidrosis (lack of sweating)-the ability to dissipate heat via evaporative mechanisms is overwhelmed. Body temperature may rise, leading to heat-related illness, including heat intolerance, hyperthermia, heat exhaustion, heat stroke, and even death. In patients seen by a dermatologist, anhidrosis may underly and contribute to their symptoms and signs but may be difficult to detect given a limited availability of tools to measure anhidrosis. An association between anhidrosis and skin symptoms including flushing syndromes (eg, facial flushing and erythromelalgia) and widespread skin symptoms (eg, itching, burning, numbness, or tingling, and paresthesias) has recently been described. This review explores the existing dermatologic literature on anhidrosis including clues to the pathophysiology of these disorders, its relationship to skin diseases and symptoms, the tests currently available, and approaches to management. Recognition of an underlying anhidrosis by dermatologists may be important for providing optimal management for patients with heat-related symptoms.

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