Journal Of The Neurological Sciences[JOURNAL]

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Comment on "Stroke preventive strategies and long-term cognitive function: A population-based study".

Jia L

J Neurol Sci · 2026 May · PMID 42250521 · Publisher ↗

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Acute akinetic collapse in Parkinson's disease: A retrospective study of sustained immobilization and clinical outcomes.

Hagiwara Y, Tomoda Y, Kobayashi S

J Neurol Sci · 2026 May · PMID 42250520 · Publisher ↗

BACKGROUND: Acute deterioration in Parkinson's disease (PD) often results in emergency hospitalization. While parkinsonism-hyperpyrexia syndrome (PHS) represents the most severe malignant form, acute motor worsening with... BACKGROUND: Acute deterioration in Parkinson's disease (PD) often results in emergency hospitalization. While parkinsonism-hyperpyrexia syndrome (PHS) represents the most severe malignant form, acute motor worsening without hyperthermia is frequently encountered. OBJECTIVE: To characterize the clinical features and outcomes of acute sustained immobilization in PD requiring emergency hospitalization. METHODS: We conducted a retrospective observational study of PD patients who developed acute immobilization lasting ≥12 h and required emergency transportation and hospitalization. Clinical characteristics, precipitating factors, laboratory findings, and outcomes were analyzed. RESULTS: Forty patients were included (mean age 76.5 ± 8.6 years; 42.5% female). Most patients were alert at admission (median Glasgow Coma Scale 15 [IQR 14-15]) and lacked hyperthermia or overt autonomic instability. Falls were the most frequent precipitating event (45%). The mean duration of immobilization before hospital arrival was 24 h (IQR 16-38). Laboratory findings indicated dehydration and muscle injury (median creatine kinase 1638 IU/L, IQR 431-4543). Mean hospital stay was 31.9 ± 22.1 days. Functional status worsened significantly, with modified Rankin Scale scores increasing from 2.5 ± 0.8 to 3.2 ± 1.0 (p < 0.001). CONCLUSIONS: Acute sustained immobilization without classical malignant features such as hyperpyrexia or autonomic instability represents a clinically significant pattern of acute motor deterioration in PD, associated with prolonged hospitalization and functional decline. We propose the term acute akinetic collapse (AAC) to describe this underrecognized clinical presentation. Recognition of AAC may facilitate earlier intervention and preventive strategies.

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Reply to the letter of editor addressed by Thulamy Raman D. Et al., about our article entitled "Radiosensitivity and delayed radiation-induced Nucleo-shuttling of the ATM protein in fibroblasts from Duchenne muscular dystrophy expressing residual dystrophin".

Foray N, Bourguignon M

J Neurol Sci · 2026 May · PMID 42247793 · Publisher ↗

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Response to "Comment on 'Upper limb plexopathy secondary to herpes zoster: A PRISMA-guided systematic case review'".

Jover-Diaz F, Parra-Muñoz L, Trigueros-Rocamora M … +3 more , Delgado-Sánchez E, Esteve-Atiénzar P, Peris-García J

J Neurol Sci · 2026 May · PMID 42242165 · Publisher ↗

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Letter to the editor on Fatigue prevalence, interactions with associated symptoms and longitudinal changes in those with multiple sclerosis: Insights from the TONiC study.

Zahra E, Azhar A

J Neurol Sci · 2026 May · PMID 42235141 · Publisher ↗

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Sexual dysfunction in Parkinson's disease: What about women?

Odhwani A, Deewan K

J Neurol Sci · 2026 May · PMID 42235140 · Publisher ↗

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Comment on "Explainable machine learning on clinical features to predict and differentiate Alzheimer's progression by sex: Toward a clinician-tailored web interface".

Mangala N, Amistapuram K, Garapati RS

J Neurol Sci · 2026 May · PMID 42235139 · Publisher ↗

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Comment on "Comparison of outcomes among generations in endovascular treatment for unruptured intracranial aneurysms: Insights from a single-center study".

Sarala G, Ganesan M, Aashish A … +1 more , Jayannan J

J Neurol Sci · 2026 May · PMID 42229336 · Publisher ↗

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The end of semiology, or the rise of precision overdiagnosis?

Tiwa TM, Sengkey SB, Sengkey MM … +2 more , Pondalos T, Padillah R

J Neurol Sci · 2026 May · PMID 42224899 · Publisher ↗

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Capturing female sexuality in Parkinson's disease.

Panichelli BS, Spitz M

J Neurol Sci · 2026 May · PMID 42224898 · Publisher ↗

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Reply to the Letter to the editor by Barnoyevich et al.

Jensen-Kondering U

J Neurol Sci · 2026 May · PMID 42224897 · Publisher ↗

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Response to the letter to the editor regarding "Comparison of outcomes among generations in endovascular treatment for unruptured intracranial aneurysms: insights from a single-center study".

Matsukawa H, Kazekawa K, Yasaka M … +8 more , Fukui Y, Maruyama K, Fujii T, Takigawa K, Tashiro N, Hashiguchi Y, Aikawa H, Go Y

J Neurol Sci · 2026 May · PMID 42218851 · Publisher ↗

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Beyond hypoxia: Systemic acidemia and respiratory insufficiency in Lance-Adams syndrome.

McDonald K, Duque KR, Tarcha L … +3 more , Lapinski C, Mahajan A, Espay AJ

J Neurol Sci · 2026 May · PMID 42217299 · Publisher ↗

Although cardiac arrests are common, most survivors do not develop post-hypoxic myoclonus (Lance-Adams syndrome, LAS), suggesting that hypoxia alone may be insufficient. We retrospectively identified LAS cases from elect... Although cardiac arrests are common, most survivors do not develop post-hypoxic myoclonus (Lance-Adams syndrome, LAS), suggesting that hypoxia alone may be insufficient. We retrospectively identified LAS cases from electronic records and video archives (2000-2025) and reviewed the literature. Among 17 patients, 12 had peri-event blood gases, all showing severe acidemia (mean pH, 7.08), with respiratory acidosis in seven and metabolic acidosis in five; the remaining five had respiratory failure. In published reports, respiratory events commonly preceded LAS. Systemic acidemia associated with respiratory insufficiency frequently accompanies hypoxic injury in LAS and may explain its rarity after isolated cardiac arrest.

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Unmasking the invisible: Correlates and impact of cognitive complaints in MS.

Elisa L, Maria P, Lorenza N … +7 more , Caterina L, Nicola C, Gabriele G, Sabrina AQ, Francesco B, Giacomo B, Matilde I

J Neurol Sci · 2026 May · PMID 42214883 · Publisher ↗

BACKGROUND: Patient-reported outcome measures (PROMs) are increasingly used in multiple sclerosis (MS) to capture subjective aspects of disease burden. However, the relationship between perceived cognitive deficits, obje... BACKGROUND: Patient-reported outcome measures (PROMs) are increasingly used in multiple sclerosis (MS) to capture subjective aspects of disease burden. However, the relationship between perceived cognitive deficits, objective cognitive impairment, psychological symptoms, and functional outcomes remains unclear. METHODS: We conducted a cross-sectional study on 263 people with MS. Objective cognition was assessed using the Brief International Cognitive Assessment for MS (BICAMS). Subjective cognitive complaints were derived from selected items of the Modified Fatigue Impact Scale, while independence was evaluated using items from the Multiple Sclerosis Impact Scale-29. Mood was assessed with the Hospital Anxiety and Depression Scale. Multivariable regression models were applied. RESULTS: Objective cognitive impairment was detected in 15.2% of patients, whereas 76.8% reported subjective cognitive difficulties. Subjective complaints were not independently associated with objective cognitive performance. Depressive symptoms emerged as the only significant predictor of perceived slowed thinking and concentration difficulties. Physical disability (EDSS) was the sole independent predictor of both dependence on others and limited independence. These findings were consistent across disability subgroups. CONCLUSIONS: Subjective cognitive complaints in MS appear to be more closely related to psychological factors than to objective cognitive impairment, while functional autonomy is primarily driven by physical disability. These results highlight the importance of integrating psychological assessment into routine clinical evaluation to better address patients' perceived cognitive difficulties and overall quality of life.

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