Patient Preference And Adherence[JOURNAL]
Sun
200 papers
Medical Coping as a Mediator Between Social Support and Illness Uncertainty in Cancer Patients Across Age Groups: A Mediation Analysis.
Wei Y, Wang Y, Cao P … +6 more , Gong Y, Gong J, Yang L, Chen J, Wang J, Li X
Patient Prefer Adherence · 2026 · PMID 41767767 · Full text
OBJECTIVE: To examine the mediating role of medical coping in the relationship between social support and illness uncertainty among patients with malignant tumors, and to explore differences across age groups. METHODS: A...
OBJECTIVE: To examine the mediating role of medical coping in the relationship between social support and illness uncertainty among patients with malignant tumors, and to explore differences across age groups. METHODS: A secondary analysis was conducted using cross-sectional data from 905 hospitalized patients. Patient-reported outcomes were measured using the Mishel Uncertainty in Illness Scale-Adult, the Social Support Rating Scale, and the Medical Coping Modes Questionnaire. Pearson correlation analyses were conducted using SPSS version 25.0, and mediation effects were tested using the PROCESS macro with bootstrap resampling. RESULTS: In the overall sample, medical coping partially mediated the relationship between social support and illness uncertainty (indirect effect: β = 0.177, SE = 0.061, bootstrap 95% CI [0.067, 0.306]). Age-stratified analyses showed a full mediation effect in younger patients (β = 1.362, SE = 0.218, 95% CI [0.875, 1.737]). In contrast, the mediation effects were weaker in middle-aged and older patients, accounting for only 2.96% and 17.65% of the total effect, respectively. These findings indicate that the mediating role of medical coping varies across age groups, with distinct patterns observed among younger, middle-aged, and older patients. CONCLUSION: In this cross-sectional sample, the results were statistically consistent with an indirect association between social support and illness uncertainty via medical coping, with age-related differences. Younger patients showed a stronger indirect association via coping, whereas middle-aged and older patients showed relatively stronger direct associations between social support and illness uncertainty.
Exploration of Reasons for Patient Loss to Follow-Up Management-A Cross-Sectional Study of Patients with Rosacea.
Huang Y, Liu X, Tan P … +1 more , Jiang X
Patient Prefer Adherence · 2026 · PMID 41767766 · Full text
BACKGROUND: Rosacea is a chronic skin condition requiring long-term management and regular follow-up for treatment optimization. However, significant patient loss to follow-up in clinical practice hinders the collection...
BACKGROUND: Rosacea is a chronic skin condition requiring long-term management and regular follow-up for treatment optimization. However, significant patient loss to follow-up in clinical practice hinders the collection of essential clinical data. This study aims to investigate the reasons for patient attrition to inform improved retention strategies and patient management. METHODS: We randomly selected 100 lost-to-follow-up patients with rosacea and 100 rosacea patients who adhered to regular follow-ups from our outpatient system and conducted a survey and interviews with them based on their basic information, disease and treatment status, exploration of reasons for loss to follow-up, and assessment of disease status and willingness to return for follow-up. RESULTS: The results indicated that demographic factors, such as gender and education level, are not the primary reasons for patient loss to follow-up. The lost-to-follow-up group exhibited milder symptoms (p<0.001) and lower treatment willingness (p<0.001), while the regular follow-up group had a higher level of disease awareness. The main reasons for patient loss to follow-up were improvement in condition and dissatisfaction with treatment outcomes. Most patients expressed satisfaction with our follow-up services. Patients desire more personalized and flexible follow-up services and patient education. CONCLUSION: Demographic factors are not the primary reasons for patient loss to follow-up, but milder symptoms and dissatisfaction with treatment outcomes are the main reasons for patients discontinuing follow-up. Effective patient education enhances patients' understanding of their condition, which encourages them to adhere to follow-up appointments.
Knowledge, Attitudes, and Practices Toward Acupuncture Among Patients with Knee Pain: A Cross-Sectional Study.
Wan X, Song S, Chen Y … +2 more , Tao Q, Zhang S
Patient Prefer Adherence · 2026 · PMID 41767765 · Full text
PURPOSE: This study aimed to evaluate the knowledge, attitudes, and practices (KAP) regarding acupuncture among patients experiencing knee pain. PATIENTS AND METHODS: A cross-sectional survey was conducted at Jiangsu Pro...
PURPOSE: This study aimed to evaluate the knowledge, attitudes, and practices (KAP) regarding acupuncture among patients experiencing knee pain. PATIENTS AND METHODS: A cross-sectional survey was conducted at Jiangsu Provincial Hospital of Traditional Chinese Medicine from November 9, 2022, to December 27, 2024. Data were gathered using a structured questionnaire designed to assess participants' demographic information and their KAP related to acupuncture. RESULTS: A total of 337 valid responses were obtained. Of these, 235 respondents (69.73%) were female, and 271 (80.42%) reported living in urban areas. Additionally, 160 participants (47.48%) resided within a 5-kilometer radius of the hospital. The knowledge, attitude, and practice scores were 5.87±2.43 (possible range: 0-12), 34.49±4.56 (possible range: 10-50), and 16.75±3.75 (possible range: 13-65), respectively. The structural equation modeling (SEM) results showed that knowledge directly affected attitude (β = 0.634, P = 0.004) and practice (β = 0.255, P = 0.023), attitude directly affected practice (β = 0.520, P = 0.019), and knowledge also indirectly affected practice through attitude (β = 0.330, P = 0.012). CONCLUSION: Patients with knee pain exhibited limited knowledge, moderately positive attitudes, and low engagement in acupuncture practices. The SEM results demonstrated that knowledge significantly influenced both attitude and practice. These findings underscore the necessity for targeted educational interventions to improve patient understanding and encourage the active use of acupuncture in managing knee pain. These conclusions are most applicable in China.
Self-Disclosure and Fear of Progression in Younger and Middle-Aged Adults with Diabetes: Chain-Mediating Roles of Social Support and Illness Perception.
Qin Y, Zhou L, Wang S … +3 more , Wang L, Zhuang L, Zhou M
Patient Prefer Adherence · 2026 · PMID 41756109 · Full text
BACKGROUND: Among younger and middle-aged adults with diabetes, fear of progression (Fop) is a prominent psychological burden that is associated with impaired self-management and poorer long-term treatment adherence. Alt...
BACKGROUND: Among younger and middle-aged adults with diabetes, fear of progression (Fop) is a prominent psychological burden that is associated with impaired self-management and poorer long-term treatment adherence. Although self-disclosure has shown benefits in alleviating Fop in other chronic conditions, its role in younger and middle-aged adults with diabetes, and the pathways through which it might relate to Fop remain unclear. PURPOSE: To examine the effect of self-disclosure on FoP among younger and middle-aged adults with diabetes and to test the chain-mediating roles of social support and illness perception using a cross-sectional design. PATIENTS AND METHODS: A survey was conducted in a tertiary hospital in Nanjing, China, from March 2023 to August 2024. Standardized scales were used to assess self-disclosure, social support, illness perception, and FoP. A multiple mediation model was tested using the PROCESS macro for SPSS (v22.0). RESULTS: A total of 193 participants were included. Self-disclosure exhibited a substantial direct impact on FoP. It also exerted indirect effects through two pathways: (1) the independent mediation of illness perception and (2) the serial mediation of social support followed by illness perception. CONCLUSION: Self-disclosure is a meaningful and modifiable psychosocial factor associated with reduced FoP among younger and middle-aged adults with diabetes. Interventions aimed at facilitating disclosure, enhancing supportive communication, and reshaping maladaptive illness perceptions may help reduce FoP and support long-term self-management and adherence.
Preferences of Patients and Cardiologists Regarding Pacemaker Characteristics in Spain: A Discrete Choice Experiment.
García Fernández FJ, Fidalgo Andrés ML, Álvarez Orozco M … +3 more , Comellas M, Viciano Delibano E, Ruiz Mateas F
Patient Prefer Adherence · 2026 · PMID 41743933 · Full text
PURPOSE: A better understanding of the preferences of patients and cardiologists for pacemaker characteristics is essential for advancing patient-centered care. We therefore aimed to identify and quantify the preference...
PURPOSE: A better understanding of the preferences of patients and cardiologists for pacemaker characteristics is essential for advancing patient-centered care. We therefore aimed to identify and quantify the preference that patients and cardiologists assign to specific characteristics. PATIENTS AND METHODS: We conducted an observational, cross-sectional, descriptive study based on a discrete choice experiment (DCE). The design was informed by a literature review, a patient focus group, and a scientific committee. RESULTS: A total of 42 patients (66.7% male, mean [SD] age 64.2 [12.1] years) and 42 cardiologists (64.3% male, mean age 47.3 [9.3] years) participated in the study. For both patients (P) and cardiologists (C), the most important characteristics of pacemakers (higher relative importance, RI) are MRI compatibility (P: 28.1%; C: 25.1%) and battery longevity (P: 22.6%; C: 23.8%). The type of follow-up is more highly valued by cardiologists than by patients (P: 10.2%; C: 21.1%), whereas pacemaker size is prioritized by patients (P: 19.1%; C: 7.7%). From the cardiologists' perspective, safety (12-month post-implantation infection rate: 19.39%) and technical aspects such as conduction system pacing (CSP) (15.14%), algorithms for minimizing unnecessary right ventricular stimulation (9.43%), and programming modes (9.11%) are also important decision drivers. CONCLUSION: MRI compatibility and battery longevity are key factors for both patients and cardiologists in decision-making. Patients also prioritize generator size and replacement processes, while cardiologists additionally focus on safety (infection rates) and technical aspects (CSP and algorithms to reduce unnecessary right ventricular stimulation).
Fear of Complications Among Patients with Type 2 Diabetes: A Latent Profile Analysis.
Liang Y, Yang Y, Zhang X … +2 more , Chen L, Su D
Patient Prefer Adherence · 2026 · PMID 41743932 · Full text
AIM: This study aimed to identify latent profiles of fear of complications among hospitalized patients with type 2 diabetes and to examine factors associated with these profiles. METHODS: A convenience sampling method wa...
AIM: This study aimed to identify latent profiles of fear of complications among hospitalized patients with type 2 diabetes and to examine factors associated with these profiles. METHODS: A convenience sampling method was employed to recruit patients with type 2 diabetes from a single tertiary hospital endocrine department for a cross-sectional study. Data were collected using a general information questionnaire, Chinese version of the Fear of Complications Questionnaire, Diabetes Distress Scale, and EuroQol Five-Dimension Three-Level Scale. Latent profile analysis was performed to classify fear of complications, and group differences were examined using univariate analyses. Multinomial logistic regression was performed to explore potential associations between related factors and group classification. RESULTS: A total of 324 valid questionnaires were collected. Individuals with fear of complications were categorized into three potential groups: low fear-stable (30%), moderate fear-complication-focused (47%), and high fear-high-risk vulnerable (23%). Multinomial logistic regression showed that, compared with the low fear-stable group, the presence of complications ( 2.591, 0.05), insulin therapy ( 4.490, 0.01), higher diabetes distress ( 2.822, 0.01), and poorer quality of life ( 0.010, 0.05) were independently associated with membership in the high fear-high-risk vulnerable group. CONCLUSION: Fear of complications among patients with diabetes exhibits significant categorical characteristics. These profiles differ in diabetes distress and quality of life, highlighting the potential value of stratified psychosocial interventions and complication-focused educational programs. Routine screening for fear of complications using validated brief tools may help healthcare professionals identify high risk patients early and provide targeted care support, particularly for the high fear-high-risk vulnerable group. Future research should prioritize this population and develop scientifically effective and targeted intervention programs.
Comparative Systematic Review of Home-Based and Center-Based Cardiac Rehabilitation of Delivery Models and Outcomes.
Karisa P, Sylviana N, Syamsunarno MRAA … +3 more , Fitria N, Tiksnadi BB, Setiawan S
Patient Prefer Adherence · 2026 · PMID 41743931 · Full text
AIM: Center-based cardiac rehabilitation (CBCR) is a cornerstone of secondary prevention, yet participation remains limited due to access constraints and adherence barriers. Home-based cardiac rehabilitation (HBCR) has e...
AIM: Center-based cardiac rehabilitation (CBCR) is a cornerstone of secondary prevention, yet participation remains limited due to access constraints and adherence barriers. Home-based cardiac rehabilitation (HBCR) has evolved from conventional telephone- and logbook-supported programs to technology-assisted telerehabilitation. However, the extent to which specific delivery models translate into clinical and patient-centered benefits remains unclear. PURPOSE: To compare HBCR and CBCR delivery models and outcomes, and to evaluate whether variation in HBCR delivery approaches is associated with differences in functional capacity, adherence, quality of life, and cardiovascular risk factors. PATIENTS AND METHODS: A PRISMA 2020-guided systematic review of randomized controlled trials compared HBCR with Phase II/III CBCR. Risk of bias was assessed using RoB 2. Outcomes were synthesized narratively, and random-effects meta-analyses (inverse-variance) were conducted where data were sufficiently comparable for VOpeak, 6-minute walk distance (6MWD), and adherence. RESULTS: Fourteen trials (2002-2023), including 1,085 participants (22-242 per study), were included. HBCR delivery clustered into traditional programs (exercise prescription with telephone/logbook follow-up) and technology-assisted models (web/app platforms, wearable monitoring, and/or video-supported supervision). Overall risk of bias was low in six trials, some concerns in seven, and high in one; concerns were most commonly related to randomization, while outcome measurement was consistently low risk. Meta-analysis favored HBCR for VOpeak at follow-up (MD 0.68 mL·kg·min, 95% CI 0.06-1.29; I=4%), whereas 6MWD showed no between-setting difference (MD -6.77 m, 95% CI -55.06 to 41.52; I=61%). Adherence modestly favored HBCR (MD 3.24 sessions, 95% CI -0.10 to 6.58; I=70%). HRQoL and cardiovascular risk factors were generally comparable. CONCLUSION: HBCR yields outcomes comparable to CBCR, with small advantages in VOpeak and adherence, supporting the scalability of HBCR, particularly technology-assisted models, to expand rehabilitation access and uptake.
Cognitive and Behavioral Transformation in Type 2 Diabetes Through a Self-Efficacy-Focused Structured Education Program: A Descriptive Qualitative Study.
Jiang X, Jiang H, Tang R … +1 more , Li M
Patient Prefer Adherence · 2026 · PMID 41737151 · Full text
PURPOSE: To explore how adults with type 2 diabetes perceived and sustained self-management 12 months after completing a Self-Efficacy-Focused Structured Education Program (SSEP). METHODS: A descriptive qualitative desig...
PURPOSE: To explore how adults with type 2 diabetes perceived and sustained self-management 12 months after completing a Self-Efficacy-Focused Structured Education Program (SSEP). METHODS: A descriptive qualitative design was employed. Seventeen participants from a multicenter randomized controlled trial in China completed in-depth, semi-structured interviews. Data were analyzed using Braun and Clarke's reflexive thematic analysis with NVivo 11. RESULTS: Five researcher-constructed themes were identified: (1) restructuring of diabetes cognition, (2) enhancement of self-efficacy, (3) reshaping of mindset through learning, (4) reconstruction and internalization of behaviors, and (5) factors influencing behavioral persistence. Participants experienced a cognitive-behavioral transformation in which reflective learning facilitated sustained behavioral change. CONCLUSION: The findings reveal a dual-process mechanism: reflective System 2 learning evolved into automatic System 1 habits supported by heuristic tools. Integrating contextual cues, visual prompts, and mobile-based nudges into future SSEP delivery may enhance habit formation and long-term adherence. Combining reflective training with ongoing family and community support could further strengthen diabetes self-management behaviors sustainability.
A Co-Design Study Developing an Early Prototype Intervention to Support Oral Anticancer Medication Use in Breast Cancer.
Seo Y, Hudmon KS, Weddle KJ … +3 more , Yih Y, Miller KD, Abebe E
Patient Prefer Adherence · 2026 · PMID 41737150 · Full text
PURPOSE: Breast cancer is the most commonly diagnosed cancer among women and a leading cause of cancer-related death. The increasing use of oral anticancer medications (OAMs) shifts responsibility for medication manageme...
PURPOSE: Breast cancer is the most commonly diagnosed cancer among women and a leading cause of cancer-related death. The increasing use of oral anticancer medications (OAMs) shifts responsibility for medication management to patients, often without adequate support. This study aimed to co-design an early-stage prototype intervention to support patients with breast cancer in managing OAMs, using a patient-centered, participatory design approach. PATIENTS AND METHODS: We conducted three rounds of participatory design (PD) sessions with five patients receiving OAMs at a federally qualified health center's outpatient breast cancer clinic, in central Indiana. Eligible participants were 18 years old or older, diagnosedwith breast cancer, and currently taking OAMs. The PD process involved three stages: (1) Inspiration-patients identified key challenges in OAM management; (2) Ideation-patients co-developed potential solutions; and (3) Convergence-patients evaluated and selected preferred design concepts. RESULTS: Participants (median age: 66; range: 38-75) identified key challenges, including side-effect management, difficulty navigating resources, and lack of clear information. Ten solution ideas were generated and grouped into three categories: resource booklet, care navigation/support, and transportation assistance. Two priority prototypes emerged: (1) a physical breast cancer handbook, and (2) an interactive treatment navigation app. Participants favored the ease of use from the handbook while appreciated the mobile app's potential for bidirectional communication and peer support features. CONCLUSION: This study highlights the value of engaging patients as co-designers in the early stages of intervention development. Both the physical handbook and interactive app show potential to support OAM adherence and management. While the two design concepts require further refinement before implementation and pilot testing, the findings offer valuable insight for potential interventions in the context of oral anticancer medications used for treating breast cancer.
Coping and Resilience in Chinese Couples with Connective Tissue Diseases: A Culturally Informed Qualitative Explanation.
Cai X, Xu S, Dong C … +1 more , Gu Z
Patient Prefer Adherence · 2026 · PMID 41737149 · Full text
PURPOSE: Connective tissue diseases (CTDs) predominantly affect women, creating complex self-care and psychosocial demands that extend to their spouses. Yet, how couple-level interactions shape outcomes-or how nurses can...
PURPOSE: Connective tissue diseases (CTDs) predominantly affect women, creating complex self-care and psychosocial demands that extend to their spouses. Yet, how couple-level interactions shape outcomes-or how nurses can harness dyadic resources in care-remains poorly understood. This study aims to explain and deeply understand how couples co-construct resilience in managing CTDs, thereby elucidating the interactional mechanisms underlying the previously observed null effect of partner coping. PATIENTS AND METHODS: A descriptive qualitative study was conducted and reported following the COREQ guidelines. Twelve couples (comprising women with CTDs and their husbands) were purposively sampled. Semi-structured joint interviews, lasting 60-90 minutes, were audio-recorded, transcribed verbatim, and analyzed using reflexive thematic analysis in NVivo 14. To ensure credibility, member checking and dual-coder consensus were employed. RESULTS: Three themes emerged: (1) emotional resonance from disease shock, involving shared disbelief, role imbalance, and contagion; (2) an evolution in dyadic coping from joint avoidance to a division of labor and finally to embodied support; and (3) the joint construction of resilience through meaning-making, trust-building rituals, and humorous future re-imagining. However, well-intentioned support was found to subvert patient autonomy, providing a key explanation for the null effect of positive dyadic coping observed in quantitative studies. CONCLUSION: Resilience is a dynamic, dyadic construct, co-constructed in moment-to-moment interactions. This necessitates viewing the couple, not the individual, as the essential unit of care in CTDs management. Interventions must therefore be designed to preserve patient autonomy while cultivating authentic emotional disclosure and collaborative problem-solving.
Prescriber- and Patient-Level Characteristics Associated with Patient Adherence to Any Antipsychotics Among Patients with Schizophrenia in the United States.
Voegel A, Naranjo RR, Diaz L … +5 more , Vanden Eynde C, Wang Y, Pilon D, Benson C, Citrome L
Patient Prefer Adherence · 2026 · PMID 41737148 · Full text
PURPOSE: Antipsychotic (AP) medication adherence is important for the management of schizophrenia. This study thus aimed to evaluate prescriber- and patient-level characteristics and long-acting injectable (LAI) treatmen...
PURPOSE: Antipsychotic (AP) medication adherence is important for the management of schizophrenia. This study thus aimed to evaluate prescriber- and patient-level characteristics and long-acting injectable (LAI) treatment use among patients with schizophrenia to determine the association between these factors and AP adherence. PATIENTS AND METHODS: Adult patients with schizophrenia in the United States were identified from Komodo Research Data (01/01/2016-06/30/2023). Patients were required to have been initiated on an oral or LAI AP (index date) during the intake period (07/01/2021-06/30/2022), by a provider who prescribed APs to ≥6 patients with schizophrenia over the intake period (index prescriber). Providers were characterized using quartiles of the proportion of LAIs over all APs prescribed during the intake period (non-LAI prescribers; Q1: low, ≤8.5% LAIs; Q2-3: intermediate, >8.5% and <27% LAIs; Q4: high, ≥27% LAIs). Adherence to any AP (proportion of days covered ≥80%) was reported over the fixed 12-month follow-up period, and factors associated with adherence were evaluated using multivariate logistic regression. RESULTS: In total, 22,255 patients were included (mean age: 40.9; male: 66%; Medicaid: 76%). At index, 82% and 18% of patients were initiated on an oral AP or LAI, respectively, with 10%, 21%, 47%, and 22% of index APs prescribed by non-, low-, intermediate-, and high-LAI prescribers, respectively. Prescription of the index AP by an intermediate- or high- LAI prescriber was associated with 39% and 63% higher odds of adherence, respectively, relative to non-LAI prescribers (both p<0.001). Prescription of an LAI versus oral index AP was associated with 25% higher odds of adherence (p<0.001). Patients of all racial/ethnic minorities had lower odds of adherence relative to White patients (all p<0.050). CONCLUSION: Adherence was higher among patients treated by high-LAI prescribers, indicating that familiarity with LAI treatment and awareness of adherence challenges may improve adherence rates among patients with schizophrenia.
Glucosuria as a Biomarker of Adherence to Sodium-Glucose Co-Transporter Protein Type 2 Inhibitors.
Escribano-Serrano J, Jiménez-Varo E, Escribano-Cobalea M … +6 more , Casto-Jarillo C, López-Ceres A, Campos-Dávila E, Hormigo-Pozo A, Franch-Nadal J, Michán-Doña A
Patient Prefer Adherence · 2026 · PMID 41737147 · Full text
PURPOSE: Adherence to treatment with sodium-glucose co-transporter protein type 2 inhibitors (SGLT2i) is essential for the successful treatment of type 2 diabetes. As SGLT2i induce glucosuria, the main study objective wa...
PURPOSE: Adherence to treatment with sodium-glucose co-transporter protein type 2 inhibitors (SGLT2i) is essential for the successful treatment of type 2 diabetes. As SGLT2i induce glucosuria, the main study objective was to assess the potential relationship between glucosuria level and adherence to SGLT2i. PATIENTS AND METHODS: The study used electronic health records of patients aged ≥45 years old that had urinalysis data. Glucosuria was classified as absent/normal (0 mg/dL), intermediate (1-1000 mg/dL), and evident (>1000 mg/dL). Renal function, expressed by estimated glomerular filtration rate and stage of chronic kidney disease (CKD), was also assessed. Adherence to SGLT2i was measured with the proportion of days covered in 6 months. RESULTS: Only 9.2% of samples showed evident glucosuria; of these, 87.5% belonged to patients treated with SGLT2i. Among these patients, glucosuria was mostly evident (78.9%). Absent glucosuria was more common in patients with CKD and in advanced KDIGO stages; therefore, in these patients glucosuria as adherence marker should be interpreted with caution.In patients treated with SGLT2i, absent glucosuria was detected in 4.5% of samples from patients with good adherence, 18.5% of samples from patients with intermediate adherence, and up to 38.5% of samples from patients with poor adherence (p <0.01). Absent glucosuria was also associated with higher blood uric acid level and lower hemoglobin and hematocrit. Absent glucosuria was more common in women and older patients. CONCLUSION: Absent glucosuria could be an easy biomarker of poor adherence in patients treated with SGLT2i in clinical practice.
Patients' Perspectives on the Role of General Practice-Based Pharmacists: A Focus Group Study.
Hazen A, Kempen T, Leendertse A … +3 more , Bouvy M, van Dijk L, Zwart D
Patient Prefer Adherence · 2026 · PMID 41737146 · Full text
BACKGROUND: An aging population, increasingly complex health conditions, and high workloads in primary care highlight the need for more efficient healthcare organisation. Integrating pharmacists into general practice can...
BACKGROUND: An aging population, increasingly complex health conditions, and high workloads in primary care highlight the need for more efficient healthcare organisation. Integrating pharmacists into general practice can improve pharmacotherapeutic care and reduce hospital admissions. In the Netherlands, this collaborative model is being explored for broader implementation. Limited research has examined how patients perceive the role of pharmacists within general practice settings. AIM: What are the perspectives of patients using chronic medications on the role of general practice-based pharmacists?. METHODS: A qualitative descriptive study using focus group interviews was conducted with patients from five health centers in the Netherlands. Between May and September 2024 five focus groups were held: two with patients who had experience with pharmacist services in general practice, three with inexperienced patients. The inclusion criterion was the use of at least one medication on a chronic basis; no exclusion criteria were applied. An independent patient representative moderated the session, using a semi-structured topic guide. Discussions were audio-recorded, transcribed, and analysed using inductive thematic analysis in NVivo 12. RESULTS: A total of 31 patients participated, with five to eight in each group. Patients recognised and trusted general practice-based pharmacists for their expertise in complex pharmacotherapy, clear role distinction from GPs and community pharmacists, and strong communication skills. Key enablers of trust included secure data handling, adequate funding, and accessibility. Pharmacists were valued for delivering personalised, proactive care, contributing to multidisciplinary networks, and reducing GP workload. It was also suggested that a pharmacist working across both community pharmacy and general practice may offer added value, though this hybrid role could potentially lead to fragmented care. CONCLUSION: Overall, patients perceived the role of the general practice-based pharmacist as a valuable addition to primary care, particularly in the management of complex medication regimens. Trust in the pharmacist's new role and clear delineation of responsibilities between health care professionals are crucial for success.
Factors Influencing Adherence to Home-Based Exercise Rehabilitation in Stroke Patients from a Temporal Perspective: An Explanatory Sequential Mixed-Methods Study.
Shao J, Cong S, Han Y … +5 more , Xu W, Wang Q, Zhang J, Wei X, Ren R
Patient Prefer Adherence · 2026 · PMID 41716752 · Full text
PURPOSE: This study aimed to examine the factors influencing the adherence of stroke patients to home-based exercise rehabilitation and to elucidate the potential driving mechanisms of temporal perspective on rehabilitat...
PURPOSE: This study aimed to examine the factors influencing the adherence of stroke patients to home-based exercise rehabilitation and to elucidate the potential driving mechanisms of temporal perspective on rehabilitation adherence. PATIENTS AND METHODS: This study employed a sequential, explanatory, and mixed-methods design. In the quantitative phase, a questionnaire survey was conducted among 289 stroke patients from January 2025 to May 2025 using convenience sampling. In the qualitative phase, 16 stroke patients were selected from the quantitative sample through purposive and maximum variation sampling to explain and supplement the quantitative findings using semi-structured interviews. RESULTS: Quantitative analysis demonstrated a significant positive correlation between temporal perspective and rehabilitation adherence, with rehabilitation intention partially mediating this relationship. Behavioral advantage exerted a negative moderating effect on the intention-adherence pathway, whereas the moderating effect of self-regulation ability did not reach statistical significance. Qualitative analysis identified four main themes: consistency belief, time-bound potency, behavioral advantage, and self-regulation ability. CONCLUSION: Temporal perspective is an important driver of adherence to home-based rehabilitation among stroke patients. As rehabilitation habits develop, behavioral patterns gradually shift from being "intention-driven" to becoming "automatic habits", thereby weakening the direct driving effect of intention. Given the potential presence of latent executive dysfunction in stroke patients, targeted assessment tools and intervention strategies should be developed to bridge the gap between intention and behavior.
Calling for Inclusive Sampling, Stakeholder Representation, and Ethical/Privacy Considerations: Methodological Reflections on a Qualitative Study of Unaccompanied Care [Letter].
Zhao FY, Fu QQ, Qian J
Patient Prefer Adherence · 2026 · PMID 41710339 · Full text
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Perspectives of Healthcare Professionals on the Treatment Landscape of Ocular Redness.
Toyos MM, Forster K, Savar S … +9 more , Aguado S, Kiskiras K, Akbas E, DiVito M, Ryan R, Gallop K, Boboridis K, Salgado-Borges JM, Alio JL
Patient Prefer Adherence · 2026 · PMID 41710338 · Full text
BACKGROUND: Ocular redness (OR) is a common clinical presentation that can significantly impact patients' health-related quality of life (HRQoL), yet treatment options have historically been limited by side effects and e...
BACKGROUND: Ocular redness (OR) is a common clinical presentation that can significantly impact patients' health-related quality of life (HRQoL), yet treatment options have historically been limited by side effects and efficacy concerns. Brimonidine tartrate 0.025% represents a newer therapeutic option, but real-world perspectives from healthcare professionals (HCPs) on its clinical utility remain understudied. METHODS: A cross-sectional exploratory qualitative interview study was conducted with 18 ophthalmologists purposively recruited from a sponsor-acquired list. Participants had experience prescribing or recommending brimonidine tartrate 0.025% and were interviewed across Spain, Portugal, Poland, the United States, and Greece. Semi-structured interviews explored current treatment landscapes, unmet needs, and experiences with brimonidine tartrate 0.025%. Transcripts were analysed using qualitative content analysis. RESULTS: Participants reported OR as highly prevalent in their practice, with dry eye disease being the most commonly cited underlying cause. HCPs described significant HRQoL impact on patients, including social embarrassment, workplace concerns, and emotional distress. Prior to brimonidine tartrate 0.025%, treatment options were limited, with traditional vasoconstrictors avoided due to rebound redness and tachyphylaxis. All participants reported brimonidine tartrate 0.025% as effective, with rapid onset and good tolerability. Key advantages included lack of rebound redness and suitability for various patient types. CONCLUSION: This study with brimonidine tartrate 0.025% prescribers found it addresses a significant unmet need in OR management, providing effective relief with improved safety profile compared to traditional options. However, emphasis on proper diagnosis and use remains crucial.
Medication Discrepancy in the Hospital-to-Home Transition Period of Elderly Chinese Patients with Coronary Heart Disease: A Qualitative Study.
Hu H, Xu W, Su PP … +2 more , Wu X, Feng X
Patient Prefer Adherence · 2026 · PMID 41710337 · Full text
PURPOSE: This study aimed to explore the factors influencing medication discrepancies in elderly patients with coronary heart disease during the hospital-to-home transition through qualitative interviews. METHODS: This s...
PURPOSE: This study aimed to explore the factors influencing medication discrepancies in elderly patients with coronary heart disease during the hospital-to-home transition through qualitative interviews. METHODS: This study used a descriptive qualitative research design. Purposive sampling was employed. Between March and September 2025, we conducted face-to-face, semi-structured interviews with sixteen elderly patients with coronary heart disease who had experienced medication discrepancies within one week after hospital discharge. All interviews were audio-recorded, transcribed, and subjected to content analysis guided by the Health Ecology Model. RESULTS: Five themes and twelve subthemes were identified: 1) Personal Characteristics, 2) Behavioral Characteristics, 3) Interpersonal Networks, 4) Living and Working Conditions, and 5) Policy Conditions. CONCLUSION: Elderly patients with coronary heart disease face challenges with medication discrepancies during the hospital-to-home transition period, influenced by factors at the individual, interpersonal, community, and policy levels. Future research should focus on this critical and vulnerable phase to develop personalized interventions for this population. Strategies such as the teach-back method and encouraging patient involvement in medication decision-making may help improve medication safety.
Decision Conflict Faced by First-Degree Relatives of Liver Cancer Patients in Liver Cancer Screening: A Cross-Sectional Study in China.
Zhang J, Xia J, Su N … +3 more , Wu Y, Wang S, Tao X
Patient Prefer Adherence · 2026 · PMID 41710336 · Full text
PURPOSE: This study aimed to investigate the level of decision conflict regarding liver cancer screening among first-degree relatives (FDRs) of liver cancer patients, and to explore its associations with decision prepara...
PURPOSE: This study aimed to investigate the level of decision conflict regarding liver cancer screening among first-degree relatives (FDRs) of liver cancer patients, and to explore its associations with decision preparation, social support, and health literacy management. PATIENTS AND METHODS: This cross-sectional study enrolled 172 FDRs of liver cancer patients from a tertiary general hospital in Chongqing, China. Data was collected using the General Information Survey, the Decision Conflict Scale, the Preparation for Decision-Making Scale, the Perceived Social Support Scale, and the Health Literacy Management Scale. Descriptive statistics, one-way analysis of variance (ANOVA), Pearson correlation analysis, and multivariate regression analysis were performed to identify factors influencing decision conflict. RESULTS: The total score of decision conflict was 33.37 (SD = 13.38). Specifically, 40.11% of participants (n = 69) reported clinically significant decision conflict (score ≥ 37.5), and an additional 36.63% (n = 63) reported scores between 25 and 37.5, indicating a tendency toward decisional delay. Multiple linear regression analysis identified the educational level of FDRs and prior liver cancer screening experience as significant determinants. Higher decision conflict scores were associated with lower decision preparation (β = -0.562, P < 0.001), lower social support (β = -0.580, P < 0.001), and lower health literacy management (β = -0.232, P = 0.023). The model accounted for 71.6% of the total variance. CONCLUSION: FDRs of liver cancer patients experience moderate decision conflict regarding liver cancer screening. To address this issue, the development of structured decision aids incorporating liver cancer screening education and clear risk-benefit information is recommended. Interventions should prioritize enhancing patients' understanding and preparedness for decision making, particularly among individuals with lower educational attainment or no prior screening experience.
Depression, Anxiety and Quality of Life in Adults and Older Adults with Irritable Bowel Syndrome (IBS): Observational Analysis of MEPS National Database.
Alwhaibi M, Almazrou SH
Patient Prefer Adherence · 2026 · PMID 41710335 · Full text
BACKGROUND: Irritable bowel syndrome (IBS) is associated with impaired health-related quality of life (HRQoL) and a high burden of comorbid mental health conditions, However, limited population-level evidence exists. The...
BACKGROUND: Irritable bowel syndrome (IBS) is associated with impaired health-related quality of life (HRQoL) and a high burden of comorbid mental health conditions, However, limited population-level evidence exists. Therefore, this study examined the relationship between anxiety, depression, and HRQoL among adult and elderly populations with IBS in the United States. METHODS: A cross-sectional observational analysis was conducted. Data were drawn from the 2017-2022 Medical Expenditure Panel Survey (MEPS). Adults aged ≥18 years with a diagnosis of IBS were included. HRQoL was assessed using the Veterans RAND 12-Item Health Survey, generating Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Adjusted multivariable linear regression models provides weighted national estimates for the associations between IBS groups (IBS only, IBS with anxiety, IBS with depression, and IBS with both) and HRQoL. Depression and anxiety were identified from MEPS using the ICD-10-CM codes. Subgroup analyses compared adults (18-64 years) and older adults (≥ 65 years). RESULTS: Among 595 adults with IBS, most were women (78%) and aged >65 years (39%). IBS with comorbid depression and/or anxiety was strongly associated with lower HRQoL. Participants with both depression and anxiety reported the poorest HRQoL (PCS mean = 38.84; MCS mean = 39.20). Regression analyses showed significant reductions in both PCS and MCS for individuals with comorbid psychiatric disorders compared with IBS only (all p<0.001). In age-stratified analyses, depression and anxiety were primarily associated with larger declines in mental HRQoL among younger adults, whereas in older adults these comorbidities were associated with reductions in both physical and mental HRQoL, with greater overall impairment in the presence of chronic comorbid conditions. Protective factors included employment, higher income, physical activity, and good self-rated health. CONCLUSION: Comorbid depression and anxiety substantially reduce both physical and mental HRQoL among individuals with IBS, with distinct age-specific patterns. Younger adults are primarily affected in mental domains, whereas older adults experience broader impairment in in physical and mental domains. These findings suggest the need for integrated clinical approaches that address both IBS and mental health to improve overall HRQoL in IBS patients.
Monetary Risk Preferences and Demand for Preventative Treatment: A Discrete Choice Experiment Among Individuals at High Risk for Lung Cancer.
Liu X, Smith IP, Janssen EM … +1 more , Mansfield C
Patient Prefer Adherence · 2026 · PMID 41710334 · Full text
PURPOSE: People's risk preferences may differ depending on the domain in which someone is taking the risk, influencing their demand for innovative medical treatment with uncertain future benefits. This study aims to exam...
PURPOSE: People's risk preferences may differ depending on the domain in which someone is taking the risk, influencing their demand for innovative medical treatment with uncertain future benefits. This study aims to examine how monetary risk preferences are associated with health risk preferences for a hypothetical lung cancer preventative treatment (one that reduces the chance of getting lung cancer) and the demand for other preventative treatments or measures. METHODS: A total of 803 individuals aged 50-80 years at high risk of lung cancer completed a hypothetical investment exercise to measure monetary risk preference, as well as a discrete-choice experiment to measure health risk preference for lung cancer preventative treatment. They also answered questions about other preventative treatments or measures and screening tests they have taken. RESULTS: On average, respondents were willing to invest $67.40 (SD= $31.20) out of $100 in the hypothetical investment exercise. Given the presented levels of benefits and side effects of hypothetical treatment, 50.2% of the participants favored lung cancer preventative treatment, 29.2% were undecided, while 20.7% disliked it. Compared to those not willing to invest any amount, those willing to invest higher amounts were less likely to fall into the no-treatment group (OR=0.171 (p<0.001) to 0.335 (p=0.049), depending on the investment amount category). Additionally, individuals who expressed greater willingness to invest were also more likely to have previously received other forms of preventative healthcare (OR=1.008, p=0.025). CONCLUSION: Monetary risk preference is related with risk preferences in health and can predict demand for preventative treatments or measures.
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