Patient Preference And Adherence[JOURNAL]
Sun
200 papers
Trajectories and Influencing Factors of Depression in Patients with H-Type Hypertension-Related Ischemic Stroke: A Single-Center Longitudinal Study.
Guo Y, Wang J, Zhao P … +8 more , Zhang M, Zhou X, Guo J, Li Q, Du S, Yuan A, Liu Y, Guo L
Patient Prefer Adherence · 2026 · PMID 42293170 · Full text
BACKGROUND: This study aimed to identify depression trajectory patterns in patients with H-type hypertension-related ischemic stroke and explore predictors using the COM-B framework. METHODS: A prospective longitudinal s...
BACKGROUND: This study aimed to identify depression trajectory patterns in patients with H-type hypertension-related ischemic stroke and explore predictors using the COM-B framework. METHODS: A prospective longitudinal study enrolled 588 patients from a Chinese tertiary hospital (September 2023-December 2024). Data were collected at six time points (admission and 1, 3, 6, 9, 12 months post-discharge). Growth mixture modeling identified trajectory classes, and multivariate logistic regression determined predictive factors. RESULTS: Four depression trajectory classes were identified: (1) Rapid Recovery group (n=155, 26.4%): swift symptom resolution; (2) Moderate Improvement group (n=70, 11.9%): moderate symptom improvement; (3) Persistent Low-Symptom group (n=102, 17.3%): optimal reference category; (4) Symptom-Aggravation group (n=261, 44.4%): exacerbation over time. Protective factors included positive health behaviors (strongest across all comparisons), first-time stroke onset, urban residence, and employed status (all p < 0.05). Risk factors included higher health knowledge levels, elevated homocysteine, unemployed/retired status, and higher social support. Notably, elevated homocysteine and higher social support were associated with worsening depression, especially in the Symptom-Aggravation group (p < 0.05). CONCLUSION: Four distinct depression trajectories were identified in H-type hypertension-related ischemic stroke patients, with specific predictors. These findings inform targeted interventions to improve depression outcomes.
Latent Profiles and Associated Factors of Health Problem-Solving Ability in Patients with Coronary Heart Disease: A Cross-Sectional Study.
Hou Q, Xing Q, Duan M … +1 more , Lan Y
Patient Prefer Adherence · 2026 · PMID 42293169 · Full text
PURPOSE: To explore the latent profile characteristics of health problem-solving ability in coronary heart disease (CHD) patients and analyze their demographic and clinical determinants, providing empirical evidence for...
PURPOSE: To explore the latent profile characteristics of health problem-solving ability in coronary heart disease (CHD) patients and analyze their demographic and clinical determinants, providing empirical evidence for tailored transitional care. PATIENTS AND METHODS: A cross-sectional study was conducted among 381 hospitalized CHD patients recruited via convenience sampling from the cardiovascular department of a tertiary hospital in Ganzhou, Jiangxi Province, China, between November 2025 and March 2026. Data were collected using a sociodemographic questionnaire, Health Problem-Solving Scale (HPSS), Cardiac Self-Efficacy Scale (CSES), Coronary Artery Disease Education Questionnaire Short Version (CADE-Q SV), and Perceived Social Support Scale (PSSS). Subgroups were identified via LPA using Mplus 8.3. Multinomial logistic regression explored associated factors using SPSS 27.0. RESULTS: The mean HPSS score was 13.65 ± 4.84. LPA identified three distinct profiles: Rational-Active Coping (26.8%), Ambivalent-Passive Adaptation (52.2%), and Negative-Impulsive Avoidance (21.0%). Compared to the Rational-Active Coping profile, higher perceived social support (OR=0.897) and self-efficacy (OR=0.825) were independent protective factors against the Ambivalent-Passive Adaptation profile (both < 0.01). Furthermore, poorer disease knowledge (OR=0.796), lower perceived social support (OR=0.785), and diminished self-efficacy (OR=0.681) emerged as significant independent risk factors for the Negative-Impulsive Avoidance profile. CONCLUSION: CHD patients exhibit significant heterogeneity in health problem-solving ability. Profiling these patients provides a practical framework for personalized clinical management. Healthcare providers could target the "Negative-Impulsive" and "Ambivalent-Passive" groups. Enhancing disease knowledge, social support, and self-efficacy can promote active problem-solving, thereby optimizing self-management and long-term clinical outcomes.
Silent Dissatisfaction Despite High Patient Satisfaction Scores: A Pilot Cross-Sectional Survey of Urban Patients with Prior Rural Care Experience at a Tokyo Dental Clinic.
Takahashi M
Patient Prefer Adherence · 2026 · PMID 42283055 · Full text
PURPOSE: This pilot study examined whether patients who had experienced medical care in both urban and rural areas perceived differences in healthcare service experiences, negative emotions, and unvoiced concerns. The st...
PURPOSE: This pilot study examined whether patients who had experienced medical care in both urban and rural areas perceived differences in healthcare service experiences, negative emotions, and unvoiced concerns. The study focused on comparative perception and silent dissatisfaction that may not be captured by conventional patient satisfaction surveys. PATIENTS AND METHODS: A cross-sectional, anonymous, self-administered paper questionnaire was conducted at a cooperating dental clinic in Tokyo. The questionnaire addressed hospital visit experiences in urban and rural areas by the same healthcare recipient. The dental clinic was used as a pragmatic field site; the survey asked about medical care experiences rather than dental satisfaction. Descriptive statistics were calculated for 90 respondents. RESULTS: Among 90 respondents, 38 (42.2%) reported that they strongly or somewhat perceived differences between urban and rural care experiences, whereas 48 (53.3%) reported little or no difference and 4 (4.4%) were missing. Among the 38 respondents who perceived differences, 17 (44.7%) reported negative emotions such as inconvenience, discomfort, dissatisfaction, or endurance. Among the 20 respondents for whom expression of concerns was applicable, 7 (35.0%) communicated their concerns to the facility, whereas 13 (65.0%) did not. Among respondents with perceived differences who answered the comparison item, 8 of 32 (25.0%) reported that they recognized the feelings because they compared facilities across regions. CONCLUSION: High satisfaction scores and low complaint rates should not be interpreted as evidence that dissatisfaction is absent. These pilot findings are consistent with, but do not directly test, a reference-point interpretation. Larger multi-site studies using validated instruments are needed to examine the proposed mechanism and its implications for patient feedback systems.
Social Support and Hospital Discharge Readiness in CHD Patients: Mediating Roles of Self-Efficacy and Adherence.
Wang D, Yang N, Wei C … +3 more , Wang J, Yuan L, Sun R
Patient Prefer Adherence · 2026 · PMID 42273252 · Full text
OBJECTIVE: To explore the associations among social support, self-efficacy, medication adherence, and discharge readiness in patients with coronary heart disease (CHD), specifically examining the mediating roles of self-...
OBJECTIVE: To explore the associations among social support, self-efficacy, medication adherence, and discharge readiness in patients with coronary heart disease (CHD), specifically examining the mediating roles of self-efficacy and medication adherence. METHODS: Participants included 463 patients with coronary heart disease (CHD) recruited from a tertiary hospital in Wuhu City (February-June 2025) via convenience sampling. To assess the key variables, we employed the Oslo-3 Social Support Scale, the GSES, the MMAS-8 [MMAS 2006 used with permission www.moriskyscale.com], and the RHDS. Data analysis was performed in SPSS 26.0 for descriptive statistics, followed by the PROCESS macro (version 3.5) to examine the hypothesized mediation pathways. RESULTS: Among the 463 participants with valid responses, the mean score for readiness for hospital discharge was 66.75±23.29. Correlation analysis indicated that social support, self-efficacy, and medication adherence were each significantly and positively associated with discharge readiness ( <0.050). Mediation analysis revealed that social support showed a significant and positive association with self-efficacy (=1.425, <0.001). The Bootstrap test confirmed a significant indirect relationship between social support and discharge readiness through the mediating role of self-efficacy (95% : [0.262,1.187]). While the moderating effect of medication adherence on the "self-efficacy→discharge readiness" pathway was not statistically significant (= 0.121), medication adherence itself showed a significant and direct positive association with readiness for hospital discharge (=4.039, <0.001). CONCLUSION: In conclusion, our findings underscore that social support exerts a significant indirect effect on readiness for hospital discharge via the mediating role of self-efficacy. Although the moderating effect of medication adherence was not supported in this specific pathway, it emerged as a critical and independent factor related to discharge readiness. Consequently, clinical nursing interventions should prioritize a multifaceted approach: mobilizing social support systems, bolstering patients' psychological self-efficacy, and rigorously reinforcing medication adherence. Such targeted strategies are beneficial to support a safe, high-quality transition from hospital to home for patients with coronary heart disease.
Efficacy of Nurse-Led WIKAP Intervention on Hypoglycemia Coping Confidence and Outcomes in Adolescents with Type 1 Diabetes Mellitus: A Quasi-Experimental Study in Zhijiang, China.
Xiao W, Zheng D, Guo Q … +1 more , Peng X
Patient Prefer Adherence · 2026 · PMID 42266228 · Full text
BACKGROUND: Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remai...
BACKGROUND: Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China. This study evaluated the effectiveness of the nurse's web-based Information-Knowledge-Attitude-Practice (WIKAP) model in improving coping confidence, reducing hypoglycemia events, and enhancing caregiver satisfaction. METHODS: This quasi-experimental, non-randomized controlled trial was conducted in the Endocrinology Department of a tertiary hospital in Zhijiang, China. A total of 110 adolescents with type 1 diabetes mellitus (T1DM) were assigned to either the WIKAP intervention group (n = 55) or routine care control group (n = 55) based on sequential enrollment period. The 8-week WIKAP intervention combined web-based and offline approaches targeting knowledge, attitude, and practice. Primary outcomes included hypoglycemia coping confidence measured by the Hypoglycemia Avoidance Behavior Scale (HABS; anxiety, avoidance, and confidence subscales), HbA1c levels, hypoglycemia incidence, and primary caregiver satisfaction. Descriptive statistics summarized baseline characteristics. Mixed-design ANOVA and MANOVA were used to analyze continuous outcomes over time, while chi-square tests compared categorical variables. Analyses were performed using SPSS 27.0 and R software. RESULTS: Doubly multivariate MANOVA revealed a significant Group × Time interaction (Pillai's Trace = 0.855, < 0.001). Compared with routine care, the 8-week WIKAP intervention significantly improved hypoglycemia coping confidence (reduced anxiety and enhanced confidence and total scores, all < 0.001), lowered hypoglycemia incidence ( = 0.015), and increased caregiver satisfaction ( = 0.002), with no significant effect on HbA1c ( = 0.851). CONCLUSION: The WIKAP model effectively improved hypoglycemia coping confidence, reduced hypoglycemia incidence, and enhanced caregiver satisfaction in adolescents with T1DM, without significant effect on HbAlc. These results support its integration into clinical diabetes care, with future multi-center studies needed to confirm long-term benefits. TRIAL REGISTRATION: ChiCTR2500104670 (registered at Chinese Clinical Trial Registry).
Patient Engagement in Person-Centered Communication About Medication Adherence: Perspectives From Patients, Next of Kin, and Healthcare Professionals.
Kudusova T, Devold HM, Lilleheim NE … +1 more , Sletvold H
Patient Prefer Adherence · 2026 · PMID 42266227 · Full text
PURPOSE: To explore how patients can be actively engaged in medication adherence communication in a person-centered manner. PATIENTS AND METHODS: A design thinking approach was applied, involving patients, next of kin, p...
PURPOSE: To explore how patients can be actively engaged in medication adherence communication in a person-centered manner. PATIENTS AND METHODS: A design thinking approach was applied, involving patients, next of kin, physicians, nurses, and pharmacists through workshops and individual interviews. Data was analyzed using reflexive thematic analysis. RESULTS: Two main themes were identified. The first, Reassurance as a foundation for person-centered communication about medication adherence, described adherence communication as a multi-layered and co‑constructed process. Reassurance was established through relational engagement and mutual trust, enabling patients to participate more openly and confidently in discussions about their medication use. The second theme, Healthcare professional as fellow human and expert, highlighted patients' need to be met "as a person" while simultaneously relying on the healthcare professional's expertise. Participants emphasized the importance of professionals who "know their stuff but speak my language" translating clinical knowledge into understandable, meaningful dialogue. A "reassuring mindset" where human and expert qualities converge, was identified as central to fostering patient engagement in adherence conversations. CONCLUSION: Reassurance was identified as a central enabling factor for engaging patients in medication-adherence communication. The findings emphasize that a synergistic combination of human connection and professional competence is essential. These results can inform the development of communication strategies and professional skills aimed at building partnerships in adherence. Further research should explore how reassurance can be operationalized in person-centered adherence interventions and its impact on treatment outcomes.
Erratum: Effects of Education on Treatment Adherence and Fatigue in Individuals with Treatment-Inadherent Iron Deficiency Anemia: A Randomized Trial in Türkiye [Corrigendum].
Patient Prefer Adherence · 2026 · PMID 42266226 · Full text
[This corrects the article DOI: 10.2147/PPA.S565466.].
[This corrects the article DOI: 10.2147/PPA.S565466.].
A Cross-Sectional Study on Knowledge, Attitude, and Practice of Tooth-Supported Complete Overdenture Among Middle-Aged and Elderly People: A Structural Equation Modeling Analysis.
Cui J, Guo G
Patient Prefer Adherence · 2026 · PMID 42261371 · Full text
INTRODUCTION: Complete overdenture is an important treatment option for edentulous patients, but limited data exist on public awareness. This study aimed to assess the knowledge, attitude, and practice (KAP) regarding co...
INTRODUCTION: Complete overdenture is an important treatment option for edentulous patients, but limited data exist on public awareness. This study aimed to assess the knowledge, attitude, and practice (KAP) regarding complete overdenture among middle-aged and elderly individuals aged 45 years and above. METHODS: A cross-sectional study was conducted from November 2023 to July 2024 at Changzhi People's Hospital in Changzhi City. RESULTS: A total of 602 participants provided valid questionnaires, including 318 females (52.82%). The participants showed poor knowledge (median score: 6 [2, 11], possible range: 0-20), positive attitude (median score: 27 [24, 30], possible range: 8-38), and positive practice (median score: 25 [20, 27], possible range: 6-30). The Structural equation modeling (SEM) analysis indicated that knowledge directly affected attitude (β = 0.572, P < 0.001), and attitude strongly influenced practice (β = 0.807, P < 0.001). Attitude fully mediated the association between knowledge and practice (indirect effect: β = 0.462, 95% CI: 0.392-0.531, P < 0.001). CONCLUSION: Middle-aged and elderly individuals showed poor knowledge but positive attitudes and practices regarding complete overdenture, indicating the need for targeted education.
Evaluation of Needs for Chronic Disease Management Services in Patients with Inflammatory Bowel Disease Based on the Kano Model: A Cross‑Sectional Study.
Feng Z, Xu C, Li C … +6 more , Yang C, Qu J, Li X, Mai G, Li H, Hu P
Patient Prefer Adherence · 2026 · PMID 42261370 · Full text
PURPOSE: To investigate and analyze the needs for chronic disease management services among patients with inflammatory bowel disease (IBD) and provide recommendations for service optimization. PATIENTS AND METHODS: A Kan...
PURPOSE: To investigate and analyze the needs for chronic disease management services among patients with inflammatory bowel disease (IBD) and provide recommendations for service optimization. PATIENTS AND METHODS: A Kano model-based questionnaire on chronic disease management service needs was developed through preliminary research. Using a convenience sampling method, 240 IBD patients were recruited for a cross-sectional survey between July 2024 and November 2024. The Kano model was applied to categorize service needs according to distinct attributes. RESULTS: Among the 32 demand items, Kano attribute categorization (based on frequency distribution of paired responses) revealed 16 one‑dimensional attributes, 15 attractive attributes, and 1 indifferent attribute No must-be or reverse attributes were identified. Satisfaction (Better) and importance (Worse) coefficients were calculated for each item, followed by matrix quadrant analysis using the mean Better (0.7204) and mean Worse (0.3936) as cutoffs. This analysis placed 14 items in the competitive advantage area (eg, Hands-on Training for Medication Use), 4 items in the improvement priority area (eg, Access to a Designated IBD Nurse Liaison), 10 items in the secondary improvement area (eg, Creation of Personal Health Records), and 4 items in the maintenance area (eg, Early Detection of Osteoporosis). CONCLUSION: This exploratory cross‑sectional Kano study found that the chronic disease management needs of IBD patients were mainly one‑dimensional and attractive attributes. These findings offer a preliminary framework for prioritizing service delivery and allocating resources accordingly, with Quadrant I (competitive advantage area) and Quadrant II (improvement priority area) guiding immediate attention.
Cultural Determinants of Assistive Health Technology Acceptance in Asian Older Adults in Low- and Middle-Income Countries: A Mixed-Methods Systematic Review with Evidence Predominantly from East Asia.
Dharmansyah D, Rahayuwati L, Pramukti I … +1 more , Mutyara K
Patient Prefer Adherence · 2026 · PMID 42253871 · Full text
PURPOSE: This mixed-methods systematic review synthesizes evidence on how cultural determinants influence acceptance of assistive health technologies (AHTs) among older adults aged 60 years and over in Asian low- and mid...
PURPOSE: This mixed-methods systematic review synthesizes evidence on how cultural determinants influence acceptance of assistive health technologies (AHTs) among older adults aged 60 years and over in Asian low- and middle-income countries (LMICs). Despite increasing availability of digital health technologies, adoption rates among elderly populations in these settings remain critically low, and the dominant technology acceptance frameworks, developed in Western contexts, may inadequately account for cultural dimensions prevalent in Asian societies. METHODS: Following a protocol pre-registered on the Open Science Framework (DOI: 10.17605/OSF.IO/8E9CD), systematic searches were conducted across PubMed, Scopus, IEEE Xplore, and Web of Science. From 488 records identified, 20 underwent full-text screening against five eligibility criteria. The most critical criterion required that cultural factors be explicitly investigated as a variable or theme. Six studies met all criteria. Quality assessment used design-matched tools: the JBI Critical Appraisal Checklist for Qualitative Research (10 items), the JBI Checklist for Analytical Cross-Sectional Studies (8 items), and the Mixed Methods Appraisal Tool (MMAT, 5 items). Synthesis followed a convergent integrated approach per JBI methodology. RESULTS: Six studies (3 qualitative, 2 quantitative, 1 mixed-methods) from China (n=4), India (n=1), and Thailand (n=1) were included. Five overarching cultural themes emerged: (1) family and filial piety as a double-edged enabler; (2) stigma and face culture (mianzi); (3) collectivist social norms; (4) trust and traditional health beliefs; and (5) digital literacy as a culturally mediated gap. Methodological quality was good: qualitative studies scored 8/10 to 10/10, the cross-sectional studies scored 6/8 and 8/8, and the mixed-methods study scored 5/5. CONCLUSION: Cultural determinants exert pervasive influence on AHT acceptance. Current acceptance frameworks require cultural adaptation. The evidence is geographically concentrated in East Asia, predominantly China, indicating an urgent need for studies from Southeast and South Asian LMICs.
More Than Just Talk: The Role of Therapist Interactions in Patient Adherence.
Hesters L, Compernolle S, Van de Velde D … +1 more , De Cocker K
Patient Prefer Adherence · 2026 · PMID 42246024 · Full text
BACKGROUND: Communication of healthcare professionals (HCPs) plays an important role in patient therapy experiences. According to Self-Determination Theory, HCPs' motivating interaction styles foster these experiences. H...
BACKGROUND: Communication of healthcare professionals (HCPs) plays an important role in patient therapy experiences. According to Self-Determination Theory, HCPs' motivating interaction styles foster these experiences. However, empirical evidence on how patients perceive their HCP's interaction styles and how these perceptions relate to their basic psychological needs, therapy motivation, and therapy adherence remains limited. METHODS: This cross-sectional study included patients who received physiotherapy or occupational therapy (N=346). Participants completed valid and reliable questionnaires to assess their perceptions of their HCP's motivating (autonomy-support, structure) and demotivating (control, chaos) interaction styles, their basic psychological needs (satisfaction, frustration), motivation toward therapy (intrinsic motivation, integrated, identified, introjected, external regulation, amotivation), and therapy adherence. Data were analyzed using Structural Equation Modeling (SEM)-analysis. RESULTS: The SEM analysis revealed that perceived autonomy-support was positively related to need satisfaction and negatively to need frustration. Perceived control was positively related to need frustration. Need satisfaction, in turn, was positively related to intrinsic motivation, integrated, identified and introjected regulation, while need frustration showed a negative relationship with intrinsic motivation and introjected regulation, and a positive association with external regulation and amotivation. Integrated and identified regulations were positively related to adherence, while external regulation and amotivation showed negative associations. CONCLUSION: These findings suggest the importance of HCPs adopting an autonomy-supportive interaction style to foster patients' need satisfaction, promote self-determined motivation, and enhance therapy adherence. Conversely, controlling interaction style undermines patient therapy experiences by increasing need frustration, reducing self-determined motivation and lowering adherence. It is recommended to focus on these components during training.
Caregivers' Preference for Antipsychotic Medication for Youth Less Than 18 Years-Old: A Discrete Choice Experiment Pilot.
Fu YH, Bozzi LM, Butler B … +1 more , dosReis S
Patient Prefer Adherence · 2026 · PMID 42246023 · Full text
BACKGROUND: Antipsychotics are often prescribed for youth with complex mental health conditions but carry risks of metabolic adverse effects. Caregivers play a key role in weighing the potential benefit of treating the u...
BACKGROUND: Antipsychotics are often prescribed for youth with complex mental health conditions but carry risks of metabolic adverse effects. Caregivers play a key role in weighing the potential benefit of treating the underlying mental health condition with the potential risk of side effects. OBJECTIVE: To evaluate caregivers' preferences for the benefits and risks of antipsychotic medication for their child and to assess how these preferences relate to treatment acceptability. METHODS: We recruited 26 caregivers of youth <18 years-old across the greater Baltimore region to pilot test a discrete choice experiment (DCE). The DCE included nine choice tasks, each with three profiles and six attributes per profile, with three for the risks (weight gain, diabetes, cholesterol) and three for the benefits (self-harm episodes, aggressive behavior, hospitalizations) of antipsychotics. For each choice task, participants first selected the most acceptable profile; second, indicated if they would use their chosen profile. Conditional logit models estimated part-worth utilities. We calculated the relative attribute importance and assessed trade-offs between attributes. Summing the part-worth utilities for attributes within each DCE profile, we identified profiles with the largest utility and assessed the acceptance of the profile chosen. RESULTS: Participants were, on average, 44 years-old; 76% were biological mothers. Nearly half of the youth (46%) had prior psychiatric hospitalization, 70% had aggression towards property, and 90% had aggression towards others. Reduction in hospitalizations (34%), days with aggressive behavior (22%), and self-harm episodes (15%) achieved greater relative importance than diabetes risk (14%), weight gain (11%), and high cholesterol (4%). Participants accepted 2.21 hospitalizations per year to reduce diabetes risk from four-fold to two-fold. Sixty-five percent of the profiles selected were those participants would use. CONCLUSION: Prioritizing outcomes over the antipsychotic metabolic adverse effects underscores the importance of eliciting caregiver preferences for the benefits and risks of medication.
Factors Associated with Treatment Adherence in People with Both Hypertension and Pre-Diabetes: A Cross-Sectional Study in a Semi-Rural Community in Thailand.
Chomchoo N, Maneesriwongul W, Chaladthanyagid K … +1 more , Keawpugdee J
Patient Prefer Adherence · 2026 · PMID 42246022 · Full text
PURPOSE: Hypertension (HTN) combined with prediabetes (pre-DM) has become an important public health concern worldwide. Patients need to adhere to both pharmacological and non-pharmacological treatments in order to regul...
PURPOSE: Hypertension (HTN) combined with prediabetes (pre-DM) has become an important public health concern worldwide. Patients need to adhere to both pharmacological and non-pharmacological treatments in order to regulate both blood pressure and blood glucose levels and reduce the risk of serious complications. This study examined factors associated with treatment adherence in people with both HTN and pre-DM. METHODS: A cross-sectional study was conducted between January and March 2025. A sample of 275 people with both HTN and pre-DM was recruited from 11 subdistrict health-promoting hospitals (HPHs) in Sai Noi, a semi-rural district in Nonthaburi Province, Thailand. Data were collected using structured questionnaires. Multiple regression analysis was used to examine factors associated with treatment adherence. RESULTS: It was revealed that female sex, knowledge about HTN and pre-DM/T2DM, social support, patient-provider relationship, convenience of traveling to health services, and convenience in using these services were significantly positively correlated with adherence to treatment. Meanwhile, experience of medication side effects, smoking, and alcohol consumption were negatively correlated with it. The multiple regression model was statistically significant in predicting treatment adherence ( = 11.36 (5, 269), < 0.001) and included overall support from family (B = 2.23, < 0.001), smoking (B = -132.61, < 0.001), experience of medication side effects (B = -89.51, = 0.004), knowledge of pre-DM/T2DM (B = 14.67, = 0.013), and patient-provider relationship (B = 2.23, = 0.033) as significant factors. CONCLUSION: Disease-related knowledge, support from family, and patient-provider relationship positively influence treatment adherence of people with both HTN and pre-DM, while side effects of medication and smoking negatively influence it. These findings provide valuable insights for health officials that could inform future intervention and management strategies for this dual-risk population.
Factors Influencing Transition Readiness in Adolescents with Systemic Lupus Erythematosus: A Qualitative Study.
Chen C, Gan S, Liu T … +5 more , Xiong H, Tang J, Lu Y, Xiang Y, Yang X
Patient Prefer Adherence · 2026 · PMID 42238840 · Full text
OBJECTIVE: This study aimed to identify the factors influencing transition readiness among adolescents with systemic lupus erythematosus, thereby providing a foundation for the development of targeted intervention progra...
OBJECTIVE: This study aimed to identify the factors influencing transition readiness among adolescents with systemic lupus erythematosus, thereby providing a foundation for the development of targeted intervention programs. METHODS: Guided by the Social-Ecological Model of Adolescent and Young Adult Readiness for Transition, a descriptive qualitative study was conducted from September 2024 to October 2025. Using purposive sampling, we recruited 17 adolescent patients with systemic lupus erythematosus, their respective caregivers, and 12 healthcare providers from a tertiary hospital in Guangdong Province, China. Semi-structured interviews were performed, and the data were analyzed using directed content analysis. RESULTS: Six themes and sixteen subthemes were identified: (1) knowledge, encompassing both the active acquisition of disease-related information and a general lack of transition awareness; (2) skills/efficacy, characterized by poor medication adherence and insufficient competence in navigating healthcare systems; (3) beliefs/expectations, reflecting recognition of the importance of transition preparation; (4) goals, primarily defined by the absence of clear transition objectives; (5) relationships, incorporating barriers such as communication challenges between patients and healthcare providers or caregivers, a lack of coordination between pediatric and adult care departments, as well as facilitators like support from healthcare providers, emotional support from caregivers, and peer encouragement; (6) psychosocial functioning, manifested as emotional distress, caregiver over-involvement, substantial family financial burdens, alongside experiences of social stigma and discrimination. CONCLUSION: This study highlights that transition readiness in adolescents with systemic lupus erythematosus is influenced by multiple interacting factors. Healthcare providers should implement tailored interventions to improve treatment adherence and self-care during the transition process.
Readiness for Hospital Discharge and 30‑Day Unplanned Readmission in Older Adult Sepsis Survivors from Internal Medicine Wards: A Cross‑Sectional Study.
Hou S, Wei L, Gong Y … +3 more , Tang Q, Huang Q, Li H
Patient Prefer Adherence · 2026 · PMID 42238839 · Full text
AIM: To investigate discharge readiness among older adult sepsis survivors and its influencing factors, and to explore the relationship with 30-day unplanned readmission. METHODS: From May 2024 to May 2025, a cohort of 3...
AIM: To investigate discharge readiness among older adult sepsis survivors and its influencing factors, and to explore the relationship with 30-day unplanned readmission. METHODS: From May 2024 to May 2025, a cohort of 330 older adult sepsis survivors was recruited from an infectious disease center in China. Before discharge, participants completed questionnaires on demographic and disease characteristics, the Readiness for Hospital Discharge Scale (RHDS), and the Quality of Discharge Teaching Scale (QDTS). A follow-up survey on the 30-day unplanned readmission was subsequently conducted. The data were analyzed using Spearman correlation and multiple linear regression. RESULTS: The mean scores for RHDS and QDTS were 93.54 ± 19.96 and 155.21 ± 24.57. RHDS was primarily influenced by the QDTS, length of hospitalization, medical expenses payment, and general self-efficacy, which together explained 43.0% of the variance. Lower discharge readiness was associated with a higher risk of unplanned readmission within 30 days. CONCLUSION: The readiness for hospital discharge of older adult sepsis survivors is moderate and influenced by multiple factors, with the quality of discharge teaching being particularly significant. Higher levels of discharge readiness are associated with a lower rate of unplanned readmission.
Treatment Satisfaction with Tenapanor: Real-World Survey of Patients with End-Stage Renal Disease and Hyperphosphatemia.
Kendrick JB, Scott LL, Gist B … +1 more , Williams LA
Patient Prefer Adherence · 2026 · PMID 42233046 · Full text
PURPOSE: Tenapanor (XPHOZAH), approved by the US FDA in October 2023, is indicated to reduce serum phosphorus in adults with chronic kidney disease on dialysis as add-on therapy in patients who have an inadequate respons...
PURPOSE: Tenapanor (XPHOZAH), approved by the US FDA in October 2023, is indicated to reduce serum phosphorus in adults with chronic kidney disease on dialysis as add-on therapy in patients who have an inadequate response to or are intolerant of any dose of phosphate binders. Unlike phosphate binders, tenapanor inhibits phosphate absorption by reducing permeability through the paracellular pathway. We report results of a real-world survey on patient perspectives of serum phosphate management while receiving tenapanor for hyperphosphatemia. PATIENTS AND METHODS: Survey invites were distributed via the ArdelyxAssist patient assistance program and survey responses were coupled to pharmacy dispensing data. Eligible participants were patients with hyperphosphatemia on maintenance dialysis receiving tenapanor for at least 7 weeks, last dispensed no more than 12 weeks before the survey. RESULTS: Among 163 respondents (60% male, median age 60), the median duration of tenapanor use was 133 days. Many patients were unaware of their current serum phosphate levels (39%) or changes since starting tenapanor (57%). Excluding these patients, 74% reported good/very good serum phosphate control and 63% noted improved control. Longer duration of tenapanor use correlated with increased awareness of ( under 0.001) and perceived improvement in phosphate control ( under 0.05). Most patients (71%) reported tenapanor was easy to take. Median prescription fill adherence was 94% and stable over time. Fifty-seven percent of patients reported improved outlook on serum phosphate management, citing better bowel movements (49%), improved serum phosphate control (33%), and reduced pill burden (14%). Patient education questions revealed that 58% of patients received information from non-clinical sources and 20% from nephrologists. CONCLUSION: The survey results suggest that patients experience positive outcomes with real-world use of tenapanor, including improved bowel movements, serum phosphate control, and reduced pill burden. These findings highlight the ability of tenapanor to address unmet needs in hyperphosphatemia management.
Influence of Mask-Wearing Attitudes on Compliance with Removable Orthodontic Devices: A Cross-Sectional Study.
Huang Z, Guan G, Zhang C … +3 more , Yang R, Mei L, Li H
Patient Prefer Adherence · 2026 · PMID 42233045 · Full text
AIM: To investigate the impact of mask-wearing on orthodontic patient compliance and to identify factors associated with adherence. METHODS: A cross-sectional questionnaire-based survey was conducted among 214 orthodonti...
AIM: To investigate the impact of mask-wearing on orthodontic patient compliance and to identify factors associated with adherence. METHODS: A cross-sectional questionnaire-based survey was conducted among 214 orthodontic patients (64.0% female; predominantly aged 19-30 years) who had used removable orthodontic devices. Data on demographics, treatment duration, appliance type, mask-wearing attitudes and wear times were collected. Key variables included mask-wearing attitudes, which were assessed on a 5-point Likert scale (ranging from "Strongly Disagree" to "Strongly Agree"), actual and recommended wear times of appliances, overall compliance (actual/recommended wear time), and daytime compliance proportion (actual daytime/total wear time). RESULTS: Although 52.2% of participants agreed that masks facilitated acceptance of unaesthetic appliances, this perception was associated with lower daytime ( = -0.568) and overall compliance ( = -0.245) (both p < 0.01). Daytime wear proportion strongly correlated with overall compliance (β = 0.74, p < 0.01). Patients with neutral mask attitudes showed higher daytime compliance than those with polarized views (p < 0.01). Gender was the only independent predictor of mask-facilitated compliance, with males reporting higher acceptance (coefficient = -0.71, p = 0.03). CONCLUSION: Most orthodontic patients believe that wearing a mask helps them accept less attractive appliances, but this belief did not lead to better treatment compliance. Those with neutral attitudes wore appliances more during the day. Daytime wear strongly predicts overall compliance. For clinicians, this means that patients who count on masks to hide their appliances may need extra attention. Rather than focusing only on reducing aesthetic concerns, efforts should also focus on helping patients build consistent daytime wear habits.
Development and Validation the Uterine Fibroid Symptom and Quality of Life Short-Form: Integrating Classical and Modern Test Theory.
Zhang Y, Xu W, Nie Y … +6 more , Zhang J, Chen D, He C, Xu F, Bai J, Shi Q
Patient Prefer Adherence · 2026 · PMID 42233044 · Full text
PURPOSE: To develop a shorter version of the uterine fibroid symptom and quality of life (UFS-QoL) questionnaire and evaluate its psychometric properties, aiming to provide a more efficient instrument for symptom and qua...
PURPOSE: To develop a shorter version of the uterine fibroid symptom and quality of life (UFS-QoL) questionnaire and evaluate its psychometric properties, aiming to provide a more efficient instrument for symptom and quality-of-life assessment. PATIENTS AND METHODS: Items were selected using classical test theory (CTT) and item response theory (IRT), and the standardized response mean was used to identify inconsistent items and to evaluate their ability to detect change. The short-form was evaluated for dimensionality, internal consistency reliability, and criterion and known-group validity. Data were obtained from a 20-center prospective cohort of premenopausal Chinese women with symptomatic uterine fibroids who underwent hysterectomy, myomectomy, or HIFU (n = 1939; development n = 969, validation n = 970). RESULTS: To improve adaptability and clinical application, we removed the self-consciousness subscale and retained only one item in the sexual functioning subscale. The resulting 11-item UFS-QoL (UFS-QoL-11) reduced the administrative burden by 70% (from 37 items to 11 items) compared to the original version. It exhibited a strong correlation with UFS-QoL in each domains (all exceeding 0.7). Exploratory factor analysis accounted for 64.22% of total variance, slightly higher than the original scale (63.60%). UFS-QoL-11 demonstrated excellent internal consistency and reliability, and sensitivity in detecting varying levels of current health status. The responsiveness of UFS-QoL-11 was comparable to that of UFS-QoL, with all effect sizes > 0.45. CONCLUSION: The UFS-QoL-11 demonstrated comparable psychometric performance to the original scale while substantially reducing the number of items. It offers a more efficient instrument for assessing symptom severity and quality of life and shows potential for use in clinical and research settings, although further validation in independent populations is warranted.
"The Ventilator Means Death": Patient and Family Beliefs, Cost Anxiety and Trust as Drivers of Mechanical Ventilation Refusal in Somali Intensive Care.
Ahmed MA, Omar AA, Siyad AO
Patient Prefer Adherence · 2026 · PMID 42233043 · Full text
Mechanical ventilation is a life-sustaining therapy, yet in Somali intensive care settings it may be perceived by families as a marker of inevitable death. This commentary examines how refusal of intubation, pressure to...
Mechanical ventilation is a life-sustaining therapy, yet in Somali intensive care settings it may be perceived by families as a marker of inevitable death. This commentary examines how refusal of intubation, pressure to discontinue ventilatory support, and self-discharge may emerge from interacting system constraints, belief-based fatalism, out-of-pocket cost anxiety, limited ICU knowledge, and trust and communication gaps related to sedation, prognosis, and goals of care. Using a patient-preference and adherence lens, we argue that some refusal events may represent modifiable non-adherence to a medically indicated plan rather than simple rejection of treatment, while emphasizing that this framing should not blame patients or families facing distress, uncertainty, and financial pressure. We propose pragmatic, culturally responsive steps that are feasible in resource-constrained ICUs, including standardized family orientation to ventilation and sedation, structured daily updates, early cost transparency linked to social support pathways, and documented non-coercive escalation for high-risk refusal. These actions may strengthen informed preference formation, reduce misunderstanding, protect patient rights, and improve alignment between family decisions and appropriate life-sustaining care. Future qualitative, audit, and implementation studies are needed to evaluate these proposed interventions in local critical care settings.
The Mediating Role of Care Preparedness Between Social Support and Relocation Stress Among Parents of Children Transferred from the PICU: A Cross-Sectional Mediation Analysis.
Lin J, Liu J, Zhang Y … +2 more , Zhang L, Liang W
Patient Prefer Adherence · 2026 · PMID 42226944 · Full text
PURPOSE: After children are transferred from the PICU to the general ward, parents experience significant relocation stress due to drastic changes in the care environment and their roles, yet the internal mechanisms for...
PURPOSE: After children are transferred from the PICU to the general ward, parents experience significant relocation stress due to drastic changes in the care environment and their roles, yet the internal mechanisms for alleviating this stress remain understudied. The purpose of this study is to examine the mediating role of care preparedness in the relationship between social support and relocation stress in parents of children transferred from the PICU and to provide empirical data for developing precise nursing interventions aimed at enhancing parental preparedness. METHODS: A cross-sectional study design was adopted, 212 parents of children transferred out of the PICU from a tertiary Grade A specialized hospital in Guangzhou were selected as study participants. Assessments were conducted using the Family Relocation Stress Syndrome Scale (FRSS, total score range 17-85, with lower scores indicating higher relocation stress), the Care Preparedness Scale (CPS, total score range 0-32, with higher scores indicating better preparedness), and the Social Support Rating Scale (SSRS, total score range 12-66, with higher scores indicating higher levels of social support). Pearson correlation analysis was used to explore relationships among the variables. Structural equation modeling and the bootstrap method (5000 resamples, 95% confidence interval) were employed to test the mediating effect of care preparedness. The total effect refers to the overall impact of social support on relocation stress, including both the direct effect and the indirect effect mediated through care preparedness. RESULTS: The relocation stress score among parents was 60.25 ± 8.10, the social support score was 42.36 ± 7.31, and the care preparedness score was 24.19 ± 6.44. Relocation stress showed a moderate positive correlation with both care preparedness, and showed a weak positive correlation with social support (higher support and preparedness are associated with lower stress), while a weak positive correlation was found between social support and care preparedness. Care preparedness played a mediating role between social support and relocation stress, accounting for 29.3% of the total effect. CONCLUSION: Care preparedness is an important mediating link through which social support of parents of children transferred out of the PICU influences relocation stress. In clinical practice, healthcare professionals should systematically assess parents' levels of social support, provide targeted structured transitional care education, focus on enhancing parents' care preparedness, and thereby effectively alleviate their relocation stress.
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