Skin Research And Technology[JOURNAL]

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RETRACTION: Effect of Minoxidil Combined With Triamcinolone Acetonide on Alopecia Areata by Microneedle Injection.

Skin Res Technol · 2025 Oct · PMID 41121644 · Full text

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Vitiligo: Ruxolitinib and Other Oral Treatment Options Beyond Ruxolitinib.

Ghani H, Tan IJ, Ghofrani S … +2 more , Tchack M, Rao B

Skin Res Technol · 2025 Oct · PMID 41117150 · Full text

BACKGROUND: Vitiligo is a chronic autoimmune disorder marked by the loss of melanocytes, causing depigmented patches across the skin. Affecting up to 2% of the global population, vitiligo presents significant psychologic... BACKGROUND: Vitiligo is a chronic autoimmune disorder marked by the loss of melanocytes, causing depigmented patches across the skin. Affecting up to 2% of the global population, vitiligo presents significant psychological impacts, particularly in those with darker skin types. Current hypotheses attribute its etiology to autoimmune destruction, genetic predisposition, and environmental triggers like trauma and stress. MATERIALS AND METHODS: A comprehensive review of recent studies was conducted using PubMed and Google Scholar, focusing on systemic treatments for vitiligo, particularly JAK inhibitors (ruxolitinib, upadacitinib, tofacitinib, ritlecitinib, and baricitinib). Eligible studies included trials and case reports on adults with vitiligo evaluating treatment efficacy, safety, and tolerability. RESULTS: Topical ruxolitinib has achieved the highest efficacy in repigmenting facial and sun-exposed areas, particularly when combined with phototherapy. Emerging evidence supports oral Janus kinase (JAK) inhibitors, especially upadacitinib and tofacitinib, for their repigmenting effects in refractory cases, though side effects like acne and neutropenia warrant monitoring. Limited evidence supports methotrexate and minocycline as adjunct therapies, with minor repigmentation observed. CONCLUSION: Advances in systemic and topical JAK inhibitors have shown promising repigmentation effects in vitiligo, particularly for localized facial lesions. Ruxolitinib cream, the first FDA-approved therapy, and other JAK inhibitors highlight a growing therapeutic approach, with ongoing trials needed to optimize efficacy and evaluate long-term safety. Combination therapy with phototherapy shows enhanced repigmentation outcomes.

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Biophysical Characteristics of Lip Vermilion among Healthy Individuals in Southern China -- Correlations between Age and Vermilion Physiology.

Wang Y, He Q, Kong F … +6 more , Cheng J, Ye R, Liang J, Ou Y, Xie J, Tan J

Skin Res Technol · 2025 Oct · PMID 41074489 · Full text

BACKGROUND: The vermilion of the lips plays an important role in the aesthetic appreciation of the lower face. However, there were few human subject studies on the vermilion of the lips in China. This study aimed to inve... BACKGROUND: The vermilion of the lips plays an important role in the aesthetic appreciation of the lower face. However, there were few human subject studies on the vermilion of the lips in China. This study aimed to investigate the physiological characteristics of lip vermilion of healthy individuals living in China. METHODS: Volunteers aged 18-55 years were divided into three age groups, namely the younger, the medium, and the older. Lip physiological indicators, including stratum corneum hydration (SCH), epidermal layer hydration (ELH) at a depth of 0.5 mm below the vermilion surface, transepidermal water loss (TEWL), instant skin elasticity (ISE), glossiness, and color were measured through objective and noninvasive measurement instruments and optical imaging techniques. Data comparison and analysis among tested physiological indicators and across various instruments were also conducted. RESULTS: Statistically significant negative correlations were identified between age and several parameters, including ISE, glossiness, the L*, a*, and b* values, as well as the erythema index (EI) for the lower lip vermilion (p < 0.05). In contrast, a positive correlation was observed between age and ELH (p < 0.05). The lower lip vermilion in the younger group exhibited markedly higher glossiness and color metrics (L*, a*, EI) compared to the older group (p < 0.05). Additionally, a clear negative relationship was noted between TEWL and both elasticity and SCH for the lower lip vermilion (p < 0.05). Futhermore, the upper lip vermilion demonstrated a higher SCH and a lower TEWL (p < 0.05) than the lower lip vermillion. Image analysis by VISIA-CR proved to be more effective for evaluating lip color than SkinColorCatch due to their different detection mechanisms. CONCLUSION: This study revealed the influence of age on lip physiological indicators, and demonstrated the correlations among non-color physiological parameters. It also highlighted the physiological disparities between the upper and lower lips. These insights may enhance our comprehension of lip vermilion physiology and offer a theoretical foundation for the efficacy assessment of lip care products.

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