Boudjema K, Robin F, Jeddou H
… +1 more, Houssel-Debry P
Rev Prat
· 2026 Apr · PMID 42083845
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), have become common clinical conditions in everyday practice. Long regar...Metabolic dysfunction-associated steatotic liver disease (MASLD) and its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), have become common clinical conditions in everyday practice. Long regarded as benign, they can lead to serious liver complications, including cirrhosis and hepatocellular carcinoma, which may require liver resection or, in selected cases, liver transplantation.The presence of steatosis or steatohepatitis increases the risk of postoperative complications after hepatic resection. In the transplant setting, MASH is an increasingly frequent indication and is reshaping the management of liver transplant recipients, who often have associated metabolic syndrome (obesity, diabetes, hypertension). After transplantation, recurrence of steatosis in the graft is almost inevitable, likely reflecting the persistence of underlying genetic and environmental factors that drive metabolic syndrome.At the same time, the rising prevalence of steatosis in the general population also affects organ donors, potentially impairing graft quality and complicating post-transplant management.The growing burden of MASLD and MASH therefore calls for close collaboration between hospital-based specialists and primary care physicians, particularly for screening, management of metabolic risk factors, and long-term follow-up of patients who have undergone liver surgery or transplantation.
Children who are victims of sexual abuse may exhibit a wide range of disorders, both in terms of their manifestations and the time it takes for them to appear. The consequences can be manifold and have severe repercussio...Children who are victims of sexual abuse may exhibit a wide range of disorders, both in terms of their manifestations and the time it takes for them to appear. The consequences can be manifold and have severe repercussions on their psychomotor development, or even major consequences on the health of adult victims in their childhood. This article, based on the author's clinical experience and a review of the literature, highlights the consequences of sexual abuse on children and the difficulties in identifying it. It describes the multiple psychological and physical consequences in the lives of children who suffer abuse. It proposes an assessment focused on identifying specific, non-specific, and suggestive disorders associated with sexual abuse.
Eating disorders (EDs) are very frequent and are increasing since the Covid-19 pandemic. They include anorexia nervosa, bulimia nervosa, binge eating disorder, avoidance and restriction disorders and their subsyndromic f...Eating disorders (EDs) are very frequent and are increasing since the Covid-19 pandemic. They include anorexia nervosa, bulimia nervosa, binge eating disorder, avoidance and restriction disorders and their subsyndromic forms. EDs affect people of all ages, they generate somatic, psychiatric and social complications. Early diagnosis and appropriate care can considerably improve the prognosis. Unfortunately, these disorders steel underdiagnosed and the specialized care pathway available are not well known. After describing eating disorders, the article outlines elements for identification and initial assessment, and discusses the main lines of treatment, which must be multidisciplinary, coordinated, gradual and tailored to each individual.
Cancer prognosis has steadily improved over recent decades. In 2025, approximately 85% of patients with cancer were in remission. The growing complexity of oncologic treatments has led to substantial gains in progression...Cancer prognosis has steadily improved over recent decades. In 2025, approximately 85% of patients with cancer were in remission. The growing complexity of oncologic treatments has led to substantial gains in progression-free survival, albeit at the cost of increased cardiotoxic risk. Cardiotoxicity most commonly manifests as heart failure or left ventricular dysfunction. Consequently, the cardiovascular mortality of individuals treated for childhood cancers, as well as of older women treated for breast cancer, now equals or even exceeds oncologic mortality.In response, the European Society of Cardiology has issued its first cardio-oncology guidelines, establishing precise thresholds for left ventricular ejection fraction, longitudinal function (as assessed by echocardiographic strain parameters), and selected cardiac biomarkers. Within this framework, it is crucial to develop robust strategies to predict, enable early detection of, and ideally prevent treatment-related adverse cardiac effects. Rigorous control of traditional cardiovascular risk factors remains the cornerstone of preventing oncology-treatment-induced cardiotoxicity.
Sergent L, Gisbert M, Frot M
… +4 more, Cantilzoglou C, de la Fontaine C, Dargent-Molina P, Descamps É
Rev Prat
· 2026 Mar · PMID 41878981
Chronic pain predominantly affects women, yet they continue to receive suboptimal care due to scientific and social biases, leading to diagnostic delays, prolonged medical wandering, and a significant impact on quality o...Chronic pain predominantly affects women, yet they continue to receive suboptimal care due to scientific and social biases, leading to diagnostic delays, prolonged medical wandering, and a significant impact on quality of life. In response to this invisibilization, patient associations have mobilized to document lived experiences, support research, and contribute to the structuring of care pathways. It is within this context that the Dolora project emerged: a participatory initiative bringing together researchers, affected women, and patient associations to co-construct an assessment and support tool for chronic pain. As a pluripathological project, Dolora aims to identify common determinants of the pain experience and to integrate dimensions often absent from traditional assessment tools.
Preterm birth is defined as any birth occurring before 37 completed weeks of gestation (WG). It affects 9.9% of live births, representing 13.4 million births a year worldwide. In France, preterm birth rate is of 7.0%. Th...Preterm birth is defined as any birth occurring before 37 completed weeks of gestation (WG). It affects 9.9% of live births, representing 13.4 million births a year worldwide. In France, preterm birth rate is of 7.0%. The causes of preterm birth can be grouped into 3 main categories: infectious/inflammatory, vascular, and other. Risk factors, preventive measures, and impact on the child's health depend of these causes. Risks of death and of neonatal complications are strongly associated with gestational age at birth. Other factors are also involved, such as birth weight (fetal growth restriction) or the administration of antenatal corticosteroids. In 2020 in France, survival rates were of 47% for children born alive at 24 WG, 80% at 26 WG, 92% at 28 WG and 97% at 31 WG.
Neonatal respiratory distress is one of the leading causes of hospitalization of preterm newborns in intensive care units. Regardless of the pathology, initial respiratory support is usually delivered nasally (non-invasi...Neonatal respiratory distress is one of the leading causes of hospitalization of preterm newborns in intensive care units. Regardless of the pathology, initial respiratory support is usually delivered nasally (non-invasive ventilation), with intubation now being much less common than in previous decades, even for the most extremely preterm babies.The most frequent respiratory pathology is respiratory distress syndrome (RDS) also termed hyaline membrane disease. It is prevented by antenatal corticosteroid therapy and very effectively treated by the administration of exogenous surfactant directly in the lungs. Apnea of prematurity can last for a long time and partly explains the need for prolonged hospitalization in intensive care units. The major risk is the progression toward bronchopulmonary dysplasia, a chronic respiratory disease of preterm babies which can have longer-term consequences. In the very long term, this pathology is likely to promote the development of adult chronic obstructive pulmonary disease.
Maillard F, Ramandraivonona N, Jubin I
… +1 more, Perroteau A
Rev Prat
· 2026 Mar · PMID 41878974
The paradox between the beneficial intention of care and procedural pain highlights tensions relating to professional knowledge, denial attitudes and organizational deficiencies. Recognizing and assessing this pain categ...The paradox between the beneficial intention of care and procedural pain highlights tensions relating to professional knowledge, denial attitudes and organizational deficiencies. Recognizing and assessing this pain category is critical for healthcare quality improvement. Current knowledge offers rich and effective preventive strategies. The multimodal approach incorporates the patient/caregiver relationship, non-pharmacological methods and preemptive analgesic administration. In this context, thanks to its properties and ease of use, EMONO (Equimolar Mixture of Oxygen and Nitrous Oxide) is a product worth knowing about and worth using, alone or in combination. Lifting the taboo and preventing procedural pain with patients is part of a process that can no longer be ignored.
Premature infants have somatic vulnerabilities that warrant specific monitoring and preventive measures in the first few months after leaving the neonatal unit. Their sensory and developmental vulnerabilities require als...Premature infants have somatic vulnerabilities that warrant specific monitoring and preventive measures in the first few months after leaving the neonatal unit. Their sensory and developmental vulnerabilities require also regular monitoring, at least until they reach the age of basic school learning. For very premature infants, coordinated monitoring is generally organized within a network for monitoring vulnerable children. Children with moderate prematurity also require special attention. Follow-up care for premature infants includes specific support for parents, who are often affected by the perinatal experience. They are the primary caregivers and developers of their children.