Revista Medico-chirurgicala A Societatii De Medici Si Naturalisti Din Iasi[JOURNAL]
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200 papers
DEPRESSION--A FELLOW TRAVELER WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
Cojocaru DC, Costin M, Bădeanu LE … +2 more , Negru RD, Aursulesei V
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793837
Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disorder that occurs primarily in women of childbearing age, immunologic abnormalities being a prominent feature of the disease. Psychiatric disord...
Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disorder that occurs primarily in women of childbearing age, immunologic abnormalities being a prominent feature of the disease. Psychiatric disorders frequently coexist, depression being the most common mood disorder in neuropsychiatric lupus. This literature review was performed through searching MEDLINE database for full-text English-language articles--original research, systematic review and updates published in the last five years (2010-2015), using the keywords "depression and systemic lupus erythematosus". The main outcomes identified were prevalence and predictors of depression in various cultural and ethnic groups, depression-related clinical issues (suicidal ideation, cognitive impairment, altered body image, sleep and sexual disturbances, influence of SLE treatment), and influence on quality of life. A multidisciplinary approach that takes into account the polymorphism and individual variability of the SLE clinical manifestations helps to improve early detection of depression, which is responsible for the increased risk of comorbidities, suicidal attempts, decreased treatment adherence, and impaired quality of life. Physicians across all specialties involved in the care for lupus patients should be aware of the major prevalence of this condition, while helping patients to cope with their disabling disease.
THE TRIBES AND TRIBULATIONS OF LARYNGOPHARYNGEAL REFLUX: A REVIEW OF RECENT STUDIES WITH IMPLICATIONS FOR INTERDISCIPLINARY COLLABORATIONS BETWEEN OTOLARYNGOLOGISTS AND GASTROENTEROLOGISTS.
Bărboi OB, Prelipcean CC, Cobzeanu MD … +6 more , Palade D, Albu-Soda A, Floria M, Chirilă I, Drug VL, Bălan G
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793836
Laryngopharyngeal reflux has been recognized since 2006 (Montreal Consensus) as an extradigestive manifestation of gastroesophageal reflux disease. However, despite numerous research studies, the relationship between the...
Laryngopharyngeal reflux has been recognized since 2006 (Montreal Consensus) as an extradigestive manifestation of gastroesophageal reflux disease. However, despite numerous research studies, the relationship between these two pathologies is yet to be fully understood. The aim of this paper is to review the literature of the last five years available via the PubMed database, looking at the controversies about the prevalence, pathophysiology and diagnosis of laryngopharyngeal reflux.
LIVER BIOPSY--IS STILL AN OPTION?
Sporea I
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793835
Abstract loading — click title to view on PubMed.
GRAPHICAL USER INTERFACE WITH APPLICATIONS IN SUSCEPTIBLE-INFECTIOUS-SUSCEPTIBLE MODELS.
Ilea M, Turnea M, Arotăriţei D … +2 more , Rotariu M, Popescu M
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204675
UNLABELLED: Practical significance of understanding the dynamics and evolution of infectious diseases increases continuously in contemporary world. The mathematical study of the dynamics of infectious diseases has a long...
UNLABELLED: Practical significance of understanding the dynamics and evolution of infectious diseases increases continuously in contemporary world. The mathematical study of the dynamics of infectious diseases has a long history. AIM: By incorporating statistical methods and computer-based simulations in dynamic epidemiological models, it could be possible for modeling methods and theoretical analyses to be more realistic and reliable, allowing a more detailed understanding of the rules governing epidemic spreading. MATERIAL AND METHODS: To provide the basis for a disease transmission, the population of a region is often divided into various compartments, and the model governing their relation is called the compartmental model. To present all of the information available, a graphical user interface provides icons and visual indicators. The graphical interface shown in this paper is performed using the MATLAB software ver. 7.6.0. MATLAB software offers a wide range of techniques by which data can be displayed graphically. The process of data viewing involves a series of operations. To achieve it, I had to make three separate files, one for defining the mathematical model and two for the interface itself. RESULTS: Considering a fixed population, it is observed that the number of susceptible individuals diminishes along with an increase in the number of infectious individuals so that in about ten days the number of individuals infected and susceptible, respectively, has the same value. If the epidemic is not controlled, it will continue for an indefinite period of time. By changing the global parameters specific of the SIS model, a more rapid increase of infectious individuals is noted. CONCLUSIONS: Using the graphical user interface shown in this paper helps achieving a much easier interaction with the computer, simplifying the structure of complex instructions by using icons and menus, and, in particular, programs and files are much easier to organize. Some numerical simulations have been presented to illustrate theoretical analysis.
ISOLATION, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF THE CRUDE POLYSACCHARIDE FROM PHYLLOPHORA PSEUDOCERANOIDES.
Trifan A, Sava D, Bucur L … +5 more , Vasincu A, Vasincu I, Aprotosoaie AC, Cioancă O, Miron A
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204674
UNLABELLED: The red seaweed Phyllophora pseudoceranoides (Gmelin) New. et Tayl, commonly found in the Romanian Black Sea coastal waters, has not been studied regarding its chemical composition and biological activities....
UNLABELLED: The red seaweed Phyllophora pseudoceranoides (Gmelin) New. et Tayl, commonly found in the Romanian Black Sea coastal waters, has not been studied regarding its chemical composition and biological activities. AIMS: The aim of the present study was to isolate, characterize and assess the in vitro antioxidant activity of the crude polysaccharide from P. pseudocerano ides. MATERIALS AND METHODS: The water soluble polysaccharide was characterized by Fourier transform infrared spectroscopy (FT-IR). Total phenolic content was determined by Folin-Ciocalteu method. Antioxidant activity was evaluated by ABTS radical cation scavenging and reducing power assays. Commercial-grade carrageenan was used as positive control. RESULTS AND DISCUSSION: FT-IR analysis of the crude polysaccharide showed characteristic bands of carrageenan-type structure. A total phenolic content of 25.08 ± 1.00 mg GAE/g was determined in the crude polysaccharide. At 1.5 mg/mL, the polysaccharide exhibited important ABTS scavenging activity (49.59 ± 0.03%) and showed a good reducing power (0.4060 ± 0.002), when compared with the positive control (ABTS scavenging activity: 30.30 ± 0.03% and reducing power: 0.2494 ± 0.002, at a concentration of 1.5 mg/mL). CONCLUSIONS: The antioxidant activity of the sulfated polysaccharide suggests its possible use as an ingredient and antioxidant agent in the food and pharmaceutical industries.
ANTIOXIDANT AND PHYTOBIOLOGICAL STUDIES ON TWO ALLIUM CEPA L. EXTRACTS.
Tătăringă G, Mircea C, Gille E … +4 more , Hăncianu M, Jităreanu A, Zbancioc AM, Cătălina Stan
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204673
AIM: To investigate the antioxidant potential of two Allium cepa L. extracts. MATERIAL AND METHODS: The antioxidant activity of the two extracts (encoded EC1 and EC2) was assessed using two methods: DPPH (2,2-diphenyl-1-...
AIM: To investigate the antioxidant potential of two Allium cepa L. extracts. MATERIAL AND METHODS: The antioxidant activity of the two extracts (encoded EC1 and EC2) was assessed using two methods: DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging capacity and determination of their reducing power; phytobiological, studies were performed using grains of Triticum aestivum L., Falmura variety. RESULTS AND DISCUSSIONS: EC1 and EC2 extracts had a particular affinity for binding DPPH radicals. At equivalent concentrations, the reducing power of EClextract was about 2 times higher compared to EC2, increasing with the concentration of the analyzed sample. The phytobiological study demonstrated that the investigated extracts had no cytotoxic and genotoxic potential.
EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS.
Cojocaru SI, Stan M, Stoian G … +1 more , Dinischiotu A
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204672
UNLABELLED: Zingiber officinale Roscoe is a very important medicinal plant, with a long history of therapeutic uses, especially in oriental traditional medicine. AIM: To investigate the cytotoxicity of a fresh ginger ext...
UNLABELLED: Zingiber officinale Roscoe is a very important medicinal plant, with a long history of therapeutic uses, especially in oriental traditional medicine. AIM: To investigate the cytotoxicity of a fresh ginger extract on some skin tumor cells compared to normal cells. MATERIAL AND METHODS: C32 amelanotic melanoma cell line and CCD human skin fibroblasts were used. The fresh extract obtained by crushing ginger rhizome was examined for phenolic content. The in vitro cytotoxicity was examined using phase contrast microscopy and MTT assay for the concentrations of 2 and 4 mg% total phenols. RESULTS: Both concentrations used for treatment induced no changes in normal the morphology and viability of fibroblasts compared to control cells. Amelanotic melanoma cells displayed profound changes in cell morphology such as cell shrinkage, rounding-up and membrane blebbing and a decrease in cell viability in a dose-dependent manner. CONCLUSIONS: Fresh ginger extract induced no changes in normal skin fibroblast viability, but caused profound cytotoxic effects on amelanotic melanoma. These results could encourage further studies regarding the intimate mechanisms of the antitumor action displayed by the fresh ginger extract.
FIXED DOSE COMBINATIONS WITH SELECTIVE BETA-BLOCKERS: QUANTITATIVE DETERMINATION IN BIOLOGICAL FLUIDS.
Mahu ŞC, Hăncianu M, Agoroaei L … +3 more , Grigoriu IC, Strugaru AM, Butnaru E
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204671
Hypertension is one of the most common causes of death, a complex and incompletely controlled disease for millions of patients. Metoprolol, bisoprolol, nebivolol and atenolol are selective beta-blockers frequently used i...
Hypertension is one of the most common causes of death, a complex and incompletely controlled disease for millions of patients. Metoprolol, bisoprolol, nebivolol and atenolol are selective beta-blockers frequently used in the management of arterial hypertension, alone or in fixed combination with other substances. This study presents the most used analytical methods for simultaneous determination in biological fluids of fixed combinations containing selective beta-blockers. Articles in Pub-Med, Science Direct and Wiley Journals databases published between years 2004-2014 were reviewed. Methods such as liquid chromatography--mass spectrometry--mass spectrometry (LC-MS/MS), high performance liquid chromatography (HPLC) or high performance liquid chromatography--mass spectrometry (HPLC-MS) were used for determination of fixed combination with beta-blockers in human plasma, rat plasma and human breast milk. LC-MS/MS method was used for simultaneous determination of fixed combinations of metoprolol with simvastatin, hydrochlorothiazide or ramipril, combinations of nebivolol and valsartan, or atenolol and amlodipine. Biological samples were processed by protein precipitation techniques or by liquid-liquid extraction. For the determination of fixed dose combinations of felodipine and metoprolol in rat plasma liquid chromatography--electrospray ionization--mass spectrometry (LC-ESI-MS/MS) was applied, using phenacetin as internal standard. HPLC-MS method was applied for the determination of bisoprolol and hydrochlorothiazide in human plasma. For the determination of atenolol and chlorthalidone from human breast milk and human plasma the HPLC method was used. The analytical methods were validated according to the specialized guidelines, and were applied to biological samples, thing that confirms the permanent concern of researchers in this field.
HYPOGLYCEMIA INDUCED BY ANTIDIABETIC SULFONYLUREAS.
Confederat L, Constantin S, Lupaşcu F … +3 more , Pânzariu A, Hăncianu M, Profire L
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204670
Diabetes mellitus is a major health problem due to its increasing prevalence and life-threatening complications. Antidiabetic sulfonylureas represent the first-line drugs in type 2 diabetes even though the most common as...
Diabetes mellitus is a major health problem due to its increasing prevalence and life-threatening complications. Antidiabetic sulfonylureas represent the first-line drugs in type 2 diabetes even though the most common associated risk is pharmacologically-induced hypoglycemia. In the development of this side effect are involved several factors including the pharmacokinetic and pharmacodynamic profile of the drug, patient age and behavior, hepatic or renal dysfunctions, or other drugs associated with a high risk of interactions. If all these are controlled, the risk-benefit balance can be equal to other oral antidiabetic drugs.
SECOND MOLAR UPRIGHTING AFTER PREMATURE LOSS OF MANDIBULAR FIRST PERMANENT MOLAR--CASE REPORT.
Cernei ER, Mavru RB, Zetui IN
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204669
INTRODUCTION: Uprighting a tipped molar by using an uprighting spring is a fundamental orthodontic treatment technique. Following a weak anchorage done only by the anterior teeth the permanent lower second molar will rot...
INTRODUCTION: Uprighting a tipped molar by using an uprighting spring is a fundamental orthodontic treatment technique. Following a weak anchorage done only by the anterior teeth the permanent lower second molar will rotate around its center of resistance, and besides the distalizing movement will occur its extrusion. Following the reaction, the mandibular anterior teeth will have a movement of intrusion. All these elements will lead to anterior open bite. Correction of vertical problems has become easier with the advent of mini-implants. CASE PRESENTATION: U.I patient aged 24 years presenting for aesthetic and functional disorders. Clinical examination reveals intraoral Class I molar malocclusion on the right sight, upper narrowing arch with a slight overbite, and the both permanent first molars on the left side lost prematurely. The tooth 37 is inclined at 600 degrees to the plane of occlusion. To avoid front opening occlusion we used an orthodontic miniscrew inserted between the canine and the first premolar on the same side to achieve the second molar up righting. Lower second molar uprighting was achieved without unwanted movements in anterior mandibular region and without molar extrusion. CONCLUSIONS: Using mini implants in uprighting a tipped molar will achieve the desired tooth movement and will reduce the number of unwanted side effects and eventually to improve patient's esthetics.
RISK FACTORS AND PREDICTORS OF CROSSBITE AT CHILDREN.
Zegan G, Dascalu CG, Mavru RB … +1 more , Golovcencu L
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204668
AIM: was to determine the etiological risk factors and predictors of crossbite' treatment at children. MATERIAL AND METHODS: 270 cases with crossbites and 255 controls with other malocclusions were uniformly evaluated. T...
AIM: was to determine the etiological risk factors and predictors of crossbite' treatment at children. MATERIAL AND METHODS: 270 cases with crossbites and 255 controls with other malocclusions were uniformly evaluated. The crossbites cases were divided in group I (anterior crossbite), group II (posterior crossbite) and group III (anterior and posterior crossbites) and were compared between them per Angle Class malocclusions, dysfunctional and dental causes, associations with other discrepancies, as well by need and types of treatment. Binary logistic regression was used to find risk factors and predictors. RESULTS: The mean age of cases was 10.25?2.770 years. There were found significant differences between the groups of crossbites cases (p<0.05). There were identified risk factors (non-attrition of deciduous teeth, Angle Class II malocclusion and permanent teeth extraction) and protective factors of the crossbite (the tooth decay of deciduous teeth, eruption anomalies and tongue-thrust swallowing). There were found predictors for early corrective treatment (sucking habit, non-attrition and buds crowding) with a precision of 78.5%; for normal treatment (mouth breathing and buds crowding) with a precision of 71.5%; for late treatment (Angle Class III malocclusion, dental crowding and TMJ disorders) with a precision of 83.0%; for maxillary expansion (eruption anomalies and buds crowding) with a precision of 77.0%; for oral associated surgery (macrodontia and TMJ disorders) with a precision of 75.9% (HL test, p > 0.05). CONCLUSION: The risk factors were dental furthermore; the predictors of treatment were adequate with dentition, etiology and disorders at age identification, suggesting the contribution of practitioners in intercepting this orthodontic emergency.
METHODS OF INTEGRATING AESTHETIC REHABILITATION INTO THE TREATMENT PLAN OF ELDERLY PATIENTS.
Scutariu MM, Surdu A, Macovei G
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204667
UNLABELLED: Dental aesthetics represents a synonym for modern, cutting edge dentistry as it is a simultaneous mixture of art and science. The materials and the technology nowadays provide the resources for achieving extr...
UNLABELLED: Dental aesthetics represents a synonym for modern, cutting edge dentistry as it is a simultaneous mixture of art and science. The materials and the technology nowadays provide the resources for achieving extremely accurate and physiognomic restorations regardless of the amplitude of the intervention needed; consequently the treatment must respect the oral health and the optimal functioning of the dental-maxillary apparatus. One of the treatment phases that precede the final result, one step ahead in the treatment, is represented by the temporary restoration. The purpose of the paper consists in assessing the importance of restoring a patient's facial aesthetics--a key element for treatment success, while going through the phases that precede the final result. MATERIAL AND METHOD: The study includes 88 patients aged between 60-90 years (median age--75 years), treated at the Department of Oro-dental Diagnosis and Gerontostomatology, between January 2012 and December 2013. The patients requested the restoration of the functions affected by odontal coronary lesions, periodontal disease or edentation, malocclusion, cranial mandibular malrelations, and unsuccessful or deteriorated odontal or prosthetic treatments. RESULTS: Dental aesthetics implies a detailed assessment of each individual case because the long term success of the beautiful result achieved depends of the optimal state of health and functionality of the entire system. The final project in the cases studied was transformed into temporary restoration and afterward into permanent restoration. CONCLUSIONS: The use of temporary prosthesis within the treatment plan is important for the patient as it contributes at maintaining his social life active and also at developing the correct techniques for providing the proper hygiene for the restored elements.
DENTAL STUDENTS' PSYCHOLOGICAL WELL-BEING DURING EXAMINATION PERIOD AND HOLIDAY.
Preoteasa CT, Imre M, Preoteasa E
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204666
INTRODUCTION: Psychological well-being is recognized as an important health component, which influences the behavior, ability to cope with stressful events, work performance, and generally the ability to achieve one's fu...
INTRODUCTION: Psychological well-being is recognized as an important health component, which influences the behavior, ability to cope with stressful events, work performance, and generally the ability to achieve one's full potential. AIM: To comparatively assess the psychological well-being of dental students during the summer semester examination period and summer holiday. MATERIAL AND METHODS: A single-arm, prospective study was conducted in second year dental students from the Faculty of Dental Medicine, Bucharest. The psychological well-being was assessed using the WHO-Five Well-being Index. RESULTS: Students' psychological well-being was statistically significantly better during the summer holiday (median=19) than during the summer semester examination period (median = 11.5), Z = 3.69, p < .001. The perceived satisfaction regarding financial means, faculty colleagues, home, family and overall life satisfaction was the same during summer semester examination period and summer holiday, but it was significantly correlated with the WHO-Five Well-being Index score corresponding to the summer holiday, and no association was observed with the WHO-Five Well-being Index score corresponding to the summer semester examination period. CONCLUSIONS: Within the limits of this study, psychological well-being is likely to be negatively influenced, on a fairly large scale, by the semester examination period. Therefore, it is recommended to identify the most appropriate methods of examination with regards to the psychological load that might be a threat to the validity of students' evaluation. Additionally, training students about adequate coping strategies, designed as interventions at individual or group level, may be required.
A PRELIMINARY EVALUATION OF RESIDENTS' PERCEPTION OF THEIR TRAINING AND KNOWLEDGE ON THREE-DIMENSIONAL IMAGING.
Deçolli Y, Haba D, Petcu AE … +3 more , Balan A, Zetu IN, Duma OO
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204665
UNLABELLED: The aim of this preliminary study was to assess the residents' perception on their training program and on their knowledge regarding the use and interpretation of three-dimensional imaging techniques in their...
UNLABELLED: The aim of this preliminary study was to assess the residents' perception on their training program and on their knowledge regarding the use and interpretation of three-dimensional imaging techniques in their clinical practice. MATERIAL AND METHODS: A multi-item questionnaire was distributed among 104 residents training in four medical specialties at the University of Medicine and Pharmacy "Grigore T. Popa" in Iaşi. RESULTS: Fifty-five residents agreed to fill in the questionnaire, achieving a participating rate of 52.88%. The majority of the respondents (74.5%) declared to indicate classic CT scans to their patients. A significantly lower fraction of the participating residents (32.7%) affirmed to indicate CBCT scans. Electronic literature was the most common information source on the use of three-dimensional imaging (52.7%). Most of the residents declared that they cannot interpret correctly CT and CBCT scans (78.2%, respectively 83.6%). A significant percentage of the respondents considered that the level of training provided on the interpretation of CT and CBCT results is very low (49.1%, respectively 60.0%). CONCLUSIONS: The residents' perception of the quality of their education regarding 3D imaging modalities, along with their perception of their knowledge in this area, indicates the necessity to improve their didactic and practical training. A further extended survey will be conducted to evaluate the educational experience of residents from all medical specialties that use 3D imaging techniques in neck and head imaging.
ANTIBIOTIC RESISTANCE SPECTRUM OF NON FERMENTING GRAM NEGATIVE BACILLI ISOLATED IN THE ORTHOPEDIC TRAUMATOLOGY CLINIC OF "SF. SPIRIDON" CLINICAL EMERGENCY HOSPITAL IAŞI.
Tucaliuc D, Alexa O, Tuchiluş CG … +4 more , Ursu RG, Tucaliuc ES, Jelihovsky I, Iancu LS
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204664
AIM: The retro-prospective analysis of antibiotic sensitivity of non-fermenting gram negative bacilli strains circulating in the Orthopedics-Traumatology Clinic from "Sf. Spiridon" Emergency Clinical Hospital in view of...
AIM: The retro-prospective analysis of antibiotic sensitivity of non-fermenting gram negative bacilli strains circulating in the Orthopedics-Traumatology Clinic from "Sf. Spiridon" Emergency Clinical Hospital in view of determining the trend of the resistance phenomenon and indicating the most useful treatment for the infections caused by these strains. MATERIAL AND METHODS: The retrospective component was conducted from 01.01.2003 to 31.12.2012, and the result of the diffusimetric antibiograms was taken from the hospital's informatics system; the prospective component of the study involved the collection of pathological products from the patients admitted during January-December 2013, who showed clinical suspicion of infection, in compliance with the general collection norms for the products destined for the bacteriological exam. RESULTS: From the total 167 strains of Pseudomonas aeruginosa isolated and identified from the patients, 48 (28.74%) were sensitive to at least one antibiotic from each tested class, 29 (17.39%) were resistant to a single antibiotic and the rest of 90 (53.89%) showed multiple resistance. We noticed a statistically significant difference between the number of strains sensitive to at least one antibiotic from each tested class and those with multiple resistance (p < 0.05). For the strains of Acinetobacter baumanii combined resistance was identified for 121 (87.04%), out of which 55 (39.56%) were resistant to two classes of antibiotics and the other (47.48%) to all three classes. The most frequently met was the association of resistance to quinolones and aminoglycosides, namely for a number of 49 strains (35.25%); only 3.59% of them were simultaneously sensitive to the three classes of antibiotics. CONCLUSION: The already high percentages and the rising trends of antibiotic resistance of non-fermenting gram-negative bacteria described in this study confirm the continuous decrease of the efficiency of antimicrobial agents and underline the necessity of a global strategy which aims at all health sectors regarding the rational use of antibiotics, on the one hand, and the continuation of studies concerning the surveillance of the antimicrobial resistance phenomenon, on the other hand.
QUALITY OF LIFE WITH MASTECTOMY FOR BREAST CANCER, IN TERMS OF PATIENTS' RESPONSES OF SF-36 QUESTIONNAIRE.
Gardikiotis I, Manole A, Azoicăi D
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204663
UNLABELLED: The aim of the study was to describe the quality of life in female patients with mastectomy performed for breast cancer. MATERIAL AND METHODS: The study was carried out in Iaşi, between October 2014-January 2...
UNLABELLED: The aim of the study was to describe the quality of life in female patients with mastectomy performed for breast cancer. MATERIAL AND METHODS: The study was carried out in Iaşi, between October 2014-January 2015, on a sample of 23 patients with mastectomy, using the SF-36 Questionnaire (Short Form-36) in a single visit, with direct questioning of patients; a secondary instrument was a general anamnestic questionnaire referring on age group, area of residence, type of surgery, associated diseases, family history, psycho-emotional traumas. RESULTS: The overall profile of the studied case was: woman of 40-49 years (47.8%), from urban area (82.6%), with a family history of neoplastic pathology (43.5%), with psycho-emotional traumas (73.9%) and a self-estimated general health as "moderate" (26.1%), with "a lot of energy" only "some of the time" (43.5%), "feeling worn out" (43.5%), and "cutting down the amount of time spent on work or other activities" (69.6%), with "moderate" (34.8%) or even "intense" (21.7%) "bodily pain", "some of the time" feeling "very nervous" (43.5%) and "so down in the dumps that nothing could cheer her up" (39.1%). The strongest correlation was found between the variable "cut down the amount of time spent on work and other activities" as a result of "physical health" (Role-physical items) and "limited in kind of work or other activities" (r = 0.898 1). CONCLUSIONS: Application of SF-36 Questionnaire in female patients with mastectomy for breast cancer highlighted that strenuous and moderate activities were limited than about half of the surveyed cases, somatic pain affecting their work and normal activities and physical and emotional health influenced the social activity of patients for more than half of the lot. It is necessary to extend the study in order to bring relevant data on the quality of life of these patients, in the social, economic and cultural center of Romania.
RETROSPECTIVE EPIDEMIOLOGIC RESEARCH ON PREVALENCE OF INFECTIONS IN SURGICALLY TREATED ONCOLOGIC PATIENTS.
Manafu E, Jari I, Filimon RM … +1 more , Manole A
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204662
UNLABELLED: The aim of this work was the retrospective study of the frequency of infections in surgically treated oncologic patients. MATERIAL AND METHODS: Our research included 753 oncologic patients treated at the Seco...
UNLABELLED: The aim of this work was the retrospective study of the frequency of infections in surgically treated oncologic patients. MATERIAL AND METHODS: Our research included 753 oncologic patients treated at the Second Surgical Clinic of the Regional Institute of Oncology, Iaşi, between January 2013 and December 2014, with the selection of cases which had infectious complications. RESULTS: The lot of patients was structured in 7 age groups and the most frequent oncologic patients had ages between 60-79 years. The most frequent malignancies were large bowel, breast, rectal, esophageal cancers, malignant hemopathies, gastric and liver malignant tumors. In our lot of 753 oncologic patients we depicted 113 (15.01%) infections. CONCLUSIONS: Our study proved that the anatomic location of the cancer, the hospitalization duration and the number of the hospitalizations has an important role in appearance of the infectious complications. The gastrointestinal malignant tumors were the most frequent malignancies associated with postoperative infections. The patients with gastrointestinal cancers from urban area, with ages between 50 and 79 years had the highest risk of infectious complications. For main causative organism was proved a high sensitivity for colistin. Clinical, paraclinical and epidemiological exams did not emphasize any decisive factors; we took into account the risks of infection during multiple pre-, intra- and postoperative procedures; all these have been associated with increased receptivity of immunosuppressed oncologic patients.
STUDY ON HEALTH PROFESSIONALS' PERCEPTION OF QUALITY OF HEALTHCARE PROVIDED TO PATIENTS.
Druguş D, Oprean C, Azoicăi D
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204661
UNLABELLED: The quality of the health care system is an essential condition for in improving the quality of health services and satisfying both the patients and healthcare professionals. RESEARCH OBJECTIVES: To identify...
UNLABELLED: The quality of the health care system is an essential condition for in improving the quality of health services and satisfying both the patients and healthcare professionals. RESEARCH OBJECTIVES: To identify the characteristics of medical profession, the factors of professional satisfaction or dissatisfaction and health care team-related factors that influence the quality of care. MATERIAL AND METHODS: Qualitative study using a SurveyMonkey online questionnaire consisting of 14 open-ended questions. The respondents were 1013 health professionals in university and non-university hospitals with various unit profiles. RESULTS: According to healthcare professionals, medical profession is defined by: humanism and personal sacrifice (33.37%) and also high professional competence (33.07%). Satisfaction factors are: patient health (40.57%), high social status (36.33) and saved lives (33.07%). Dissatisfaction may be due to: low salary (39.98%), disorganization (38.10%) and lack of procedures (33.96%). Performance may decrease as a result of: stressful working conditions, lack of adequate medical supplies, lack of recognition at work, routine, and strained relations with superiors. CONCLUSIONS: The study shows the need for correlating the medical education system and health systems, and for an integrated analysis of both systems by determining the required skills and modeling the medical team behavior in accordance with the performance variables which take into account satisfaction among both patients and health care professionals.
ELECTRONIC CIGARETTE--A WAY OF SMOKING CESSATION?
Postolache P, Nemeş RM, Şerban RI … +2 more , Rad RM, Stratulat IS
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204660
Specialists have the ethical obligation to promote smoking cessation using evidence-based therapeutic strategies. In the context of the growing popularity of the electronic cigarettes (ECs), the smokers asking us about i...
Specialists have the ethical obligation to promote smoking cessation using evidence-based therapeutic strategies. In the context of the growing popularity of the electronic cigarettes (ECs), the smokers asking us about it and we must be ready to provide expert advice. With the evidence available to date we must be cautious in recommending of the smokers to use ECs for smoking cessation because these have not proven superiority over drugs used for smoking cessation approved by the Food and Drug Administration (FDA), ECs are not FDA approved, short-term safety data shows that they cause airway reactivity and health risk of exposure to ECs in the long term is unknown. Before the ECs to occupy a place in the standard clinical approaches for the treatment of tobacco addiction longer needed more data about their safety clinical and regulatory of their use.
DETECTION OF HUMAN PAPILLOMA VIRUS IN HEAD AND NECK SQUAMOUS CELL CARCINOMAS: A LITERATURE REVIEW.
Jelihovschi I, Bidescu AC, Tucaliuc SE … +1 more , Iancu LS
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26204659
Human papilloma viruses (HPV) are the most common sexually transmitted viruses. There is mounting evidence that incriminates HPV as a risk factor for malignant transformation of oropharyngeal epithelium. In 2011 the Inte...
Human papilloma viruses (HPV) are the most common sexually transmitted viruses. There is mounting evidence that incriminates HPV as a risk factor for malignant transformation of oropharyngeal epithelium. In 2011 the International Research Agency of Cancer and National Cancer Institute (USA) declared HPV-16 as an independent risk factor for oropharyngeal squamous cell carcinoma (OPSCC). Leaders in the field of HPV research admit that this subtype of head and neck cancer is a sexually transmitted entity and its global incidence is on the rise. In the 1980s, clinicians observed a new group of patients with head and neck squamous cell carcinoma (HNSCC) independent of tobacco smoking or alcohol use. The new HNSCC patient is a middle-aged man, non-smoker, non-drinker with higher social status and the suspected risk factors for HNSCC being related to sexual practices (oral sex, multiple sexual partners, unprotected sex and drug use). Routine HPV testing of HNSCC patients is seriously considered as HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical and pathologic entity that has a markedly better prognosis than HPV-negative oropharyngeal cancers. The current treatment protocols for OPSCC include radiation, chemotherapy and surgery alone or in combination, involving high toxicity levels. Future therapeutic concepts for OPSCC may be personalized in relation to HPV-status to avoid unnecessary toxicity. The current review summarizes the contemporary trends in the diagnosis of HPV-related head and neck cancers, presenting the advantages and disadvantages of the main methods.
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