Revista Medico-chirurgicala A Societatii De Medici Si Naturalisti Din Iasi[JOURNAL]
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200 papers
ATOPIC DERMATITIS--CLINICAL EPIDEMIOLOGY AND IMMUNOLOGICAL CORRELATIONS.
Coclici SE, Bozomitu LI, Mîndru DE … +2 more , Moraru E, Hăncianu M
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125071
AIM: Medical records from 2010-2014 were retrospectively reviewed and analyzed in view of determining the correlations between the clinical severity of atopic dermatitis (AD) and total IgE level, eosinophilia, place of r...
AIM: Medical records from 2010-2014 were retrospectively reviewed and analyzed in view of determining the correlations between the clinical severity of atopic dermatitis (AD) and total IgE level, eosinophilia, place of residence, family history of atopy, type of birth, and natural or artificial feeding. MATERIAL AND METHODS: Following medical record review, 296 cases diagnosed with AD were included in the study. Statistical analysis was performed using SPSS v20 for determining the frequency and testing the hypotheses, for p < 0.05, by t tests and One-Way ANOVA. RESULTS: Of the 296 cases, 53% were male children and 47% female children aged 1 month to 16 years. According to total serum IgE level, 49.3% of patients had elevated IgE levels, 20.6% normal levels and in 30.03% of cases it was not determined. According to the SCORAD, children had mild AD in 20% of cases, moderate in 70%, and severe in 10%. The independent samples t tests showed a statistically significant difference between the means demonstrating correlations between IgE level and place of residence (p < 0.01), family history of atopy (p < 0.01), baby feeding (p < 0.01), and by one-way ANOVA for SCORAD (p < 0.05). CONCLUSIONS: Atopy in AD can be influenced by complex factors, both internal and environmental, but this remains a controversial topic. External factors acting on a background genetically predisposed to atopy trigger the manifestation of AD.
ANEMIA IN INFLAMMATORY BOWEL DISEASE MORE THAN AN EXTRAINTESTINAL COMPLICATION.
Nemeş RM, Pop CS, Calagiu D … +4 more , Dobrin D, Chetroiu D, Jantea P, Postolache P
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125070
The most common hematologic complication of inflammatory bowel disease (IBD)--ulcerative colitis and Crohn's Disease is anemia. Anemia in patients with IBD may be a result of iron, vitamin B12 or folate deficiency; anemi...
The most common hematologic complication of inflammatory bowel disease (IBD)--ulcerative colitis and Crohn's Disease is anemia. Anemia in patients with IBD may be a result of iron, vitamin B12 or folate deficiency; anemia of chronic disease and hemolytic anemia are other causes in these patients. Factors contributing to the development of anemia include chronic gastrointestinal blood loss, vitamin B12 malabsorption secondary to terminal ileitis, folate deficiency as a result of sulfasalazine therapy. Approximately 30% of patients with IBD have hemoglobin levels below 12 g/dl. The risk of developing anemia relates to disease activity, given that blood loss and inflammatory anemia are triggered by intestinal inflammation. In the management strategy of IBD patients with anemia it is important to distinguish between the different types of anemia in order to decide an appropriate manner of treatment.
NADPH OXIDASE: STRUCTURE AND ACTIVATION MECHANISMS (REVIEW). NOTE I.
Filip-Ciubotaru F, Manciuc C, Stoleriu G … +1 more , Foia L
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125069
NADPH oxidase (nicotinamide adenine dinucleotide phosphate-oxidase), with its generically termed NOX isoforms, is the major source of ROS (reactive oxigen species) in biological systems. ROS are small oxygen-derived mole...
NADPH oxidase (nicotinamide adenine dinucleotide phosphate-oxidase), with its generically termed NOX isoforms, is the major source of ROS (reactive oxigen species) in biological systems. ROS are small oxygen-derived molecules with an important role in various biological processes (physiological or pathological). If under physiological conditions some processes are beneficial and necessary for life, under pathophysiological conditions they are noxious, harmful. NADPH oxidases are present in phagocytes and in a wide variety of nonphagocytic cells. The enzyme generates superoxide by transferring electrons from NADPH inside the cell across the membrane and coupling them to molecular oxygen to produce superoxide anion, a reactive free-radical. Structurally, NADPH oxidase is a multicomponent enzyme which includes two integral membrane proteins, glycoprotein gp9 1 Phox and adaptor protein p22(phox), which together form the heterodimeric flavocytochrome b558 that constitutes the core of the enzyme. During the resting state, the multidomain regulatory subunits p40P(phox), p47(phox), p67(Phox) are located in the cytosol organized as a complex. The activation of phagocytic NADPH oxidase occurs through a complex series of protein interactions.
NONSELECTIVE BETA-BLOCKERS IN PATIENTS WITH CIRRHOSIS: "THE THERAPEUTIC WINDOW".
Dimache M, Gîrleanu I, Carpov E … +2 more , Trifan A, Stanciu C
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125068
For over 30 years, nonselective beta-blockers (NSBB) have been successfully used for preventing variceal bleeding in patients with cirrhosis and portal hypertension. Nevertheless, recent studies suggest that NSBB may be...
For over 30 years, nonselective beta-blockers (NSBB) have been successfully used for preventing variceal bleeding in patients with cirrhosis and portal hypertension. Nevertheless, recent studies suggest that NSBB may be effective only within a particular "therapeutic window" in patients with advanced liver disease. Outside of this window, in early stages of cirrhosis and in very advanced cirrhosis, NSBB may be ineffective and even potentially harmful. In this paper we review the beneficial effects and potential harms of beta-blocker therapy in cirrhosis and underline the most recent recommendations for their use in very advanced cases of liver disease.
ETHICAL AND GENETIC ASPECTS REGARDING PRESYMPTOMATIC TESTING FOR NEURODEGENERATIVE DISEASES.
Cozaru GC, Aşchie M, Mitroi AF … +2 more , Poinăreanu I, Gorduza EV
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125067
Neurodegenerative diseases, such as Alzheimer's dementia, Huntington's chorea, Parkinson's disease or spinocerebellar ataxia, manifests into adulthood with an insidious onset, slowly of progressive symptoms. All of these...
Neurodegenerative diseases, such as Alzheimer's dementia, Huntington's chorea, Parkinson's disease or spinocerebellar ataxia, manifests into adulthood with an insidious onset, slowly of progressive symptoms. All of these diseases are characterized by presimptomatic stages that preceded with many years of clinical debut. In Parkinson's disease, more than half of the dopaminergic neurons of the black substance are lost before the advent of motor characteristic manifestations. In Huntington's chorea, the progressive neurodegenerative disease could be diagnose prenatal and presymptomatic by analyse of the number of CAG repeats in exon 1 of the huntingtin gene. A similar mechanism represented by expansion of trinucleotide repeats during hereditary transmission from parents to children was identified in fragile X syndrome, spinocerebellar ataxia, spinal muscular and bulbar atrophy, or myotonic dystrophy. Presymptomatic diagnosis in all these progressive diseases raise many ethical issues, due to the psychological impact that can cause the prediction of a disease for which there is currently no curative treatment. Therefore, a positive result can produce serious psychological trauma and major changes in the lifestyle of the individual, instead, a negative result can bring joy and tranquillity. But the problem arises if presymptomatic testing in these neurodegenerative diseases brings greater benefits compared to the possible psychological damage, which can add the risk of stigmatization or discrimination.
ADHD (ATTENTION DEFFICIT HYPERACTIVITY DISORDER)--A TROUBLING ENTITY, SOMETIMES PERPETUATING DURING ADULT LIFE.
Amihăesei IC, Zamfir CL
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125066
Attention deficit hyperactivity disorder (ADHD) is considered a neurologic development disorder resulting in impairment of attention and inhibitory control, manifested as attention deficit, hyperactivity, impulsiveness;...
Attention deficit hyperactivity disorder (ADHD) is considered a neurologic development disorder resulting in impairment of attention and inhibitory control, manifested as attention deficit, hyperactivity, impulsiveness; symptoms should develop between age six and twelve and have to persist for more than six months. Approximately 30-50% of the diagnosed cases are manifesting the disorder during adulthood and 2.5-5% of the adults are suffering of ADHD. Genetics are important factors in ADHD, being involved in 75% of the cases, as well in the persistence of ADHD during adult life. Three subtypes of ADHD are described--one in which is predominating the attention deficit, one with predominant hyperactivity and impulsiveness and a third combined subtype. Diagnosis criteria in ADHD are established by the American Psychiatric Association (DSM criteria) and by World Health Organization. Differential diagnosis is mainly considering bipolar disorder and borderline personality disorder. Management of ADHD is including behavioral therapies and medication, alone or combined. Stimulant medications such as amphetamine represent the therapy of choice, being effective in 80% of the cases. New data are underlying the need for following up of the cases during adulthood, since the risk for development of psychiatric conditions such as depression, anxiety, as well as the suicidal behavior is higher than in the general population.
HUMAN PAPILLOMAVIRUS AND SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK.
Cobzeanu MD
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27125065
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A NEW SPECTROPHOTOMETRIC METHOD FOR THE ASSAY OF LISINOPRIL.
Vieriu M, Tântaru G, Apostu M … +2 more , Panainte AD, Bibire N
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793870
AIM: A new spectrophotometric method for the assay of lisinopril using 2,4-dinitrophenol as reagent is described. MATERIAL AND METHODS: The method involved the addition of 2,4-dinitrophenol to lisinopril in methanol foll...
AIM: A new spectrophotometric method for the assay of lisinopril using 2,4-dinitrophenol as reagent is described. MATERIAL AND METHODS: The method involved the addition of 2,4-dinitrophenol to lisinopril in methanol followed by absorbance measurement at 400 nm. Experimental conditions that provide wide linear range, maximum sensitivity, selectivity, accuracy and precisions were optimized. RESULTS AND DISCUSSIONS: Beer's law was obeyed in the concentration range 2.0-14.0 μg/mL. Linear regression equation of calibration graph was A = 0.005 + 0.045 x concentration, with a regression coefficient (r) of 0.9995 (n = 8). The limits of detection (LOD) and quantification (LOQ) calculated according to the ICH guidelines were 0.42 and 1.42 μg/mL, respectively. Accuracy and precision of the assays were determined by computing the intra-day and inter-day variations at three different lisinopril concentrations; the intra-day and inter-day RSD was < 1.43% and accuracy was better than 1.72%. CONCLUSIONS: The proposed method is simple, easy to perform, sensitive, linear, precise, accurate and robust.
ANTINFLAMMATORY ACTIVITY OF AN N, N'-DISALICYLIDENEMETHYLENDIAMINE-DERIVED SCHIFF BIS BASE AND ITS COPPER(II) COMPLEX.
Tântaru G, Nechifor M, Apostu M … +3 more , Vieriu M, Panainte AD, Bibire N
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793869
AIM: The cooper(II) complex combination of N, N'-disalicylidenemethylenediamine and the Schiff bis base were investigated for anti-inflammatory activity. MATERIAL AND METHODS: In vivo, the anti-inflammatory activity of t...
AIM: The cooper(II) complex combination of N, N'-disalicylidenemethylenediamine and the Schiff bis base were investigated for anti-inflammatory activity. MATERIAL AND METHODS: In vivo, the anti-inflammatory activity of the metallic complex in comparison with the activity of the Schiff bis base was tested by the method of Winter and co-workers using the Levy technique. RESULTS AND DISCUSSIONS: Our study on the anti-inflammatory activity of a new Schiff bis base and its complex cooper(II) combination showed that the Schiff bis bases exhibited significant anti-inflammatory action in acute experimental inflammation when compared to the control group. The copper cation from the complex combination enhanced the anti-inflammatory effect of the Schiff bis base, the effect being stronger at doses of 10 mg/kg cooper(II) complex. CONCLUSIONS: The Schiff bis base and its cooper(II) complex had an anti-inflammatory effect comparable to that of indomethacin.
IN VITRO TESTING OF XANTHAN/LIGNIN HYDROGELS AS CARRIERS FOR CONTROLLED DELIVERY OF BISOPROLOL FUMARATE.
Răschip IE, Panainte AD, Pamfil D … +2 more , Profire L, Vasile C
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793868
AIM: To develop sustained release matrix tablets based on xanthan as highly water-soluble, cost-effective, non-toxic, easily available, and suitable hydrophilic systems. MATERIAL AND METHODS: Xanthan and lignin epoxy-mod...
AIM: To develop sustained release matrix tablets based on xanthan as highly water-soluble, cost-effective, non-toxic, easily available, and suitable hydrophilic systems. MATERIAL AND METHODS: Xanthan and lignin epoxy-modified resin (LER) mixture were crosslinked using epichlorohydrin as crosslinking agent leading to superabsorbent hydrogels with high swelling rate in aqueous mediums. RESULTS AND CONCLUSIONS: These hydrogels were tested as carries by the loading/delivery behaviour of bisoprolol fumarate in physiological conditions and based on the obtained results these hydrogels may show interest for application in medical and pharmaceutical areas. The amount of drug loaded in polymer networks was found to be ranging between 14.4% and 19.2%. Drug release was retarded and the release mechanism of the active principle was found to depend on matrix composition.
α,β-DIBROMOCHALCONE DERIVATIVES--SYNTHESIS AND ANTIMICROBIAL ACTIVITY.
Jităreanu A, Zbancioc AM, Tuchiluş C … +3 more , Balan M, Stănescu U, Tătărîngă G
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793867
AIM: To obtain some chalcones and their dibrominated analogues and to evaluate their antimicrobial potential. MATERIAL AND METHODS: Eight chalcones were synthesized using the Claisen-Schmidt condensation of acetophenone/...
AIM: To obtain some chalcones and their dibrominated analogues and to evaluate their antimicrobial potential. MATERIAL AND METHODS: Eight chalcones were synthesized using the Claisen-Schmidt condensation of acetophenone/4-bromo-acetophenone and different benzaldehyde derivatives. These chalcones were further brominated using two different bromination agents: molecular bromine and pyridinium tribromide. The antimicrobial activity was tested using the disk diffusion method. RESULTS AND DISCUSSIONS: The classical bromination technique was compared to the eco-friendly one using pyridinium tribromide. Pyridinium tribromide bromination did not improve the reaction yields (except for one compound), but it had the advantage of being a stable, non-corrosive and non-toxic salt. The results of the antimicrobial assessment indicated that the bromination of the double bond slightly increased the antimicrobial potential in some cases, but the results obtained during the antimicrobial evaluation were modest, some of the derivatives being active especially on Sarcina lutea ATCC 9341 and Bacillus cereus ATCC 14579. CONCLUSIONS: In this study, eight chalcones and their dibrominated analogues were synthesized, four of the α,β-dibromochalcones being reported for the first time. Pyridinium tribromide was used as an alternative for liquid bromine, the main advantage of this method being related to the reduced toxicity of the reagents. The synthesized compounds did not exhibit a very good antimicrobial potential.
DEVELOPMENT AND VALIDATION OF THE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE QUANTITATIVE DETERMINATION OF ERYTHROMYCIN IN DERMO-PREPARATIONS.
Hortolomei M, Ochiuz L, Popovici I … +3 more , Timofte D, Petrescu DC, Ghiciuc CM
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793866
PURPOSE: For the analysis of erythromycin (ER) in topical pharmaceutical forms we developed a high performance liquid chromatography dosage method (HPLC) greatly improved over the method formalized by the European Pharma...
PURPOSE: For the analysis of erythromycin (ER) in topical pharmaceutical forms we developed a high performance liquid chromatography dosage method (HPLC) greatly improved over the method formalized by the European Pharmacopoeia 5th ed. MATERIALS AND METHODS: The work conditions for using a chromatography column with C18 stationary phase were established as follows: optimal column temperature, 45 degrees C; the mobile phase consisted of a mixture of 0.001 M disodium phosphate solution : acetonitrile in the ratio 20:80, volume of sample injected 20 μL, injection rate 1 mL/min and spectrum was recorded at λ = 200 nm. The method was validated by determining the following parameters: system precision, linearity, limit of detection (LOD), limit of quantification (LOQ) and accuracy. RESULTS: We determined linearity in the concentration range studied, 0.025 to 1.5 mg/mL. The equation of the regression line is: A = 53.7430 x C + 0.00203 with a regression coefficient of 0.9997. The method has LOQ = 0.0196 mg/mL and LOD = 0.005969. The accuracy of the method is appropriate, the ER recovery degree is in the range of 101.27 - 104.99%. CONCLUSIONS: The HPLC method with UV detection for the quantitative determination of ER is manageable, responsive, linear, precise and accurate and it can be used for the quantitative analysis of ER in topical pharmaceutical formulations. UV DETECTION.
DIVALENT CATIONS PROFILE IN PATIENTS WITH LIVER CIRRHOSIS AND VARICEAL BLEEDING.
Dumea M, Cimpoesu DC, Nechifor M
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793865
AIM: The objective of this study is to evaluate divalent cations serum levels (magnesium, zinc, copper) in liver cirrhossis and one of its major complication (variceal bleeding). MATERIAL AND METHODS: A prospective case-...
AIM: The objective of this study is to evaluate divalent cations serum levels (magnesium, zinc, copper) in liver cirrhossis and one of its major complication (variceal bleeding). MATERIAL AND METHODS: A prospective case-control study including 60 patients with liver cirrhosis complicated with variceal bleeding admitted to the Emergency Department, and 35 subjects without liver cirrhosis which served as group control. Serum concentrations of zinc, copper and magnesium were determined using atomic absorption spectrophotometer. RESULTS: The concentration of magnesium was significantly lower between patients with liver cirrhosis (11.6 ± 2.77mg/l) vs group control study (17.7 = 3.86 mg/l) (p < 0.001), regarding decreased magnesium levels and the presence of complications as hepatic encephalopathy, ascites (Child C class). Serum concentrations of zinc were decreased (0.77 ± 0.35 mg/l) compared to control group (p < 0.001) in patients with liver cirrhosis and variceal bleeding. Serum levels of copper were increased (1.69 ± 0.722 mg/l) compared to control group in patients with liver cirrhosis and variceal bleeding and are also correlated with serum albumin levels (p < 0.001, Pearson coefficient r-0.631). CONCLUSIONS: Variceal bleeding in patients with liver cirrhosis is associated to important imbalances in blood concentrations of zinc, copper and magnesium.
OPTIMIZATION OF THE PREPARATION OF KOLLIDON SR-BASED AMIODARONE HYDROCHLORIDE TABLETS WITH SUSTAINED RELEASE.
Creţeanu A, Tàntaru G, Vieriu M … +2 more , Panainte AD, Ochiuz L
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793864
AIM: The formulation of sustained release tablets of AMD-HCl using KOLLIDON SR as matrix-forming agent. Chitosan, a natural polysaccharide with superior hydrating and absorbing properties was used in the formulation stag...
AIM: The formulation of sustained release tablets of AMD-HCl using KOLLIDON SR as matrix-forming agent. Chitosan, a natural polysaccharide with superior hydrating and absorbing properties was used in the formulation stage to optimize the release characteristics of those matrix tablets. MATERIAL AND METHODS: Nine formulations of sustained release matrix tablets of AMD x HCl (200 mg/tablet) were prepared through direct compression. The concentrations of matrix forming agents were included as independent variables of a type 2(3) mixed factorial plan in order to develop formulations of AMD-HCl with optimal release characteristics. The dependent variables of that plan were the amount of AMD released from the tablets studied by using in vitro dissolution testing. The test was carried out in the paddle apparatus II for 12 hours in two pH media that were relevant to oral delivery: 2 hours at pH 1.2 and 10 hours at pH 6.8. The released AMD-HCl was quantitatively determined through a validated HPLC method. RESULTS: The increase in KOL concentration leads to a decrease in AMD release rate at both pH values. The use of CHT resulted in a decrease of AMD release only at pH 6.8 in formulations with the lowest concentration of KOL. CONCLUSIONS: The retarding effect on the release of AMD-HCl in the tablets developed in this study was directly proportional to the KOL concentration in the formulation.
CEPHALOMETRIC FEATURES OF CLASS III MALOCCLUSION.
Zegan G, Dascălu C, Mavru RB … +1 more , Anistoroaei D
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793863
AIM: The study aimed to identify quantitative and relational characteristics of bone, dental and soft tissue structures for Class III malocclusion, according to gender and age range. MATERIAL AND METHODS: 60 conventional...
AIM: The study aimed to identify quantitative and relational characteristics of bone, dental and soft tissue structures for Class III malocclusion, according to gender and age range. MATERIAL AND METHODS: 60 conventional lateral cephalograms were divided into two groups according to ANB angle: the group of cases with skeletal Class III (n = 36) and a control group with skeletal Class I (n = 24). There were performed 53 digital cephalometric measurements according to Steiner, Tweed and Jarabak analyzes. The Kolmogorov-Smirnov, t-student and Levene tests were used to find the characteristics of Class III, using SPSS 16.0 for Windows. RESUITS: We found 14 parameters that distinguished the two classes disorders (the angles SNB, SND, FMA, IMPA, MeGoOcP, Mand 1-MeGo, NSAr, ArGoMe, NGoMe and SNPog; the distances Ao-Bo and lu-NPog; Holdaway and AFH ratios) and 3 parameters for the Class III age ranges (NGoAr angle, Ls-NsPog' distance and S-Ar:Ar-Go ratio) (p ≤ 0.05). There were found no significant differences between genders for skeletal Class III. CONCLUSION: Emphasizing the cephalometric characteristics of Class III malocclusion, with the overall growth together with dental and occlusion development, requires early orthodontic therapy.
CONTRIBUTIONS TO RECOGNITION OF SOME PARTICULARITIES OF THE LINGUAL MUCOSA CONDITIONS.
Scutariu MM, Surdu A, Macovei G
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793862
UNLABELLED: Part of the oral cavity structure, the tongue plays an important role, both by its functions, and pathology, which sometimes can seriously damage the state of the entire body. As an important component of the...
UNLABELLED: Part of the oral cavity structure, the tongue plays an important role, both by its functions, and pathology, which sometimes can seriously damage the state of the entire body. As an important component of the dento-maxillary apparatus, the tongue has particular appreciative and perceptive abilities, also playing a role in articulation. The conditions of the mucosa and profound tissues of the tongue are generically named glossitis. Glossitis encompasses a wide range of conditions, from the common saburral deposits up to various forms of glossitis or the impressive tumoral lesions. MATERIAL AND METHOD: A clinical-statistical study has been conducted on a group of 24 patients, females and males, 55 - 70 years old, in order to monitor the detection of the lingual mucosa lesions. RESULTS: The damage of the lingual mucosa of the examined patients was subject to statistical analysis, revealing 24 patients with lingual mucosa lesions. The analysis of the type of lesion highlighted the diversity of the presented forms of lesions. CONCLUSIONS: For a proper medical conduct, the dentist should know the degree of involvement of the aggravating factors in the onset of oral mucosa lesion, its particularities, and apply them in a customized manner; proper examination can be very important in detecting and treating these conditions.
ETIOLOGY AND RESISTANCE PROFILE OF ISOLATED STRAINS FROM SEVERE SYSTEMIC INFECTIONS IN PATIENTS WITH IMMUNODEPRESSION--EXPERIENCE OF THE IASI INFECTIOUS DISEASES HOSPITAL 2011-2014.
Pleşca CE, Luca MC, Luca AS … +2 more , Constantinescu S, Iancu LS
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793861
UNLABELLED: Microbial resistance is an increasingly serious threat to global public health and it is linked to patient's age, immune status, and also antibiotic overuse or misuse and repeated hospitalizations. The high i...
UNLABELLED: Microbial resistance is an increasingly serious threat to global public health and it is linked to patient's age, immune status, and also antibiotic overuse or misuse and repeated hospitalizations. The high incidence of infections caused by multidrug-resistant bacteria requires rethinking the first-line therapeutic schemes. AIM: Retrospective study of the etiologic and antibiotic resistance profile of the bacterial strains isolated from immunocompromised hosts diagnosed with severe systemic infections, aimed at gaining a better understanding of the potential infectious sources and optimizing the antibiotic therapy. MATERIAL AND METHODS: 178 cases of severe sepsis associated with immunosuppression (caused by diabetes, malignancies, liver cirrhosis, chronic alcohol abuse, kidney failure) were admitted to the "St. Parascheva" Infectious Diseases Hospital Iaşi in the interval January 2011- December 2014. RESULTS: The mean age of the study patients was 61 years, most patients being female (53%) and living in urban areas (51%). The causal agents were: Escherichia coli (20.2%), Klebsiella pneumoniae (16.8%), Pseudomonas aeruginosa (14.6%), Methicillin-Sensitive Staphylococcus aureus (MSSA) (11.2%), Enterococcus spp. (10.1%), Methicillin-Resistant Staphylococcus aureus (MRSA) (8.9%), Proteus spp.(5%), Acinetobacter baumanii (5%), Streptococcus pyogenes (1.6%), Staphylococcus epidermidis (1.1%) and Citrobacter (0.5%). As to the resistance profile the following were found: 100% susceptibility of MRSA and Enterococcus species to vancomycin, as well as for the Enterococcus species; 27% of E. coli strains were resistant to beta-lactams and 20% of Klebsiella pneumoniae to carbapenems. Antibiotic therapy associated two or three drugs with an immediate result and a favorable outcome in 84.2% of the cases. CONCLUSIONS: The etiological agents implicated in the occurrence of severe sepsis in patients with acquired immunosuppression were Gram-positive bacteria (GPB) as well as Gram-negative bacteria (GNB) with moderate resistance to usual antibiotics. The infections caused by GNB were predominant in immunocompromised patients, but also in those with associated urinary and respiratory tract infections and chronic indwelling urinary catheters. In our severe sepsis patients Gram positive bacteria caused mainly skin and joint infections.
PREDICTORS OF SUICIDE RISK IN INCARCERATED MALE OFFENDERS: THE ROLE OF PERSONALITY DISORDERS.
Mihai C, Robu V, Knieling A … +2 more , Iliescu DB, Chirita R
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793860
AIM: This paper summarizes the results of a cross-sectional study aimed at exploring the role of personality disorders in predicting the suicide risk among males imprisoned for various offenses. MATERIAL AND METHODS: The...
AIM: This paper summarizes the results of a cross-sectional study aimed at exploring the role of personality disorders in predicting the suicide risk among males imprisoned for various offenses. MATERIAL AND METHODS: The data set used in analyses was based on the responses of 124 males imprisoned for various violent or non-violent offenses (M(age) = 32.39 years, SD = 8.43 years). Male offenders were interviewed using a form for demographic data and information on suicidal history. Also, they completed the Suicide Behaviors Questionnaire-Revised, as part of a broader protocol used in an ongoing study focused on the psychosocial and pharmacological aspects relevant to the diagnosis and management of personality disorders among inmates. RESULTS: At the time of data collection, forty-three respondents (34.7%) were diagnosed with at least one personality disorder. Data were analyzed using hierarchical multiple linear regression. The frequency of suicide attempts during the periods of freedom and during incarceration were significant predictors of suicide risk. Moreover, the diagnosis of personality disorder brought a significant addition to the power of final regression model, explaining almost 8% of the variance in suicide risk among the inmates. CONCLUSIONS: The findings highlight the importance of implementing prevention programs in correctional institutions, with screening and monitoring of inmates diagnosed with severe mental disorders as an important component.
BURNOUT SYNDROM AMONG PUBLIC AMBULANCE STAFF.
Iorga M, Dascalu N, Soponaru C … +1 more , Ioan B
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793859
UNLABELLED: Healthcare professionals are frequently confronted with urgent situations and a high-risk human intervention. They are usually exposed to what is called burnout syndrome. AIM: To identify the effects of burno...
UNLABELLED: Healthcare professionals are frequently confronted with urgent situations and a high-risk human intervention. They are usually exposed to what is called burnout syndrome. AIM: To identify the effects of burnout syndrome on the professional conduct and attitudes of doctors and nurses who work in the Romanian public ambulance service. Secondary, the causal relationships between burnout and various socio-demographic variables were analyzed. MATERIAL AND METHODS: The 20-item Toronto Alexithymia Scale (TAS- 20), Maslach Burnout Inventory and Job Satisfaction Questionnaire were administered to 122 ambulance doctors, nurses and drivers (62 females and 60 males). RESULTS: The degree of job satisfaction is the most important indicator of burnout syndrome. Significant differences were found between low and high alexithymic subjects. Women are more susceptible to experience higher levels of burnout than men. The level of burnout is influenced by the combined effect of job satisfaction and alexithymia. CONCLUSIONS: Burnout syndrome is a common problem among people working in the emergency medical system. The causes of job-related burnout have to be identified in order to apply an appropriate level of burnout intervention program and to increase the efficiency of coping strategies.
ADDITIONAL DEMOGRAPHIC AND CLINICAL EVIDENCES ON THE RELEVANCE OF THE SYSTEMIC THERAPY IN ALCOHOL DEPENDENCE.
Alexinschi O, Chirita R, Manuela P … +5 more , Ciobica A, Dobrin R, Petrariu FD, Timofte D, Chirita V
Rev Med Chir Soc Med Nat Iasi · 2015 · PMID 26793858
The modern treatment for alcohol dependence is still problematic, in many cases with the costs exceeding benefits. In these conditions a new management approach was developed lately, known as the systemic therapy. In thi...
The modern treatment for alcohol dependence is still problematic, in many cases with the costs exceeding benefits. In these conditions a new management approach was developed lately, known as the systemic therapy. In this way, the crystallization and practical transposition of this new treatment approach is represented by the Clubs of Alcoholics in Treatment. These clubs are in fact a form of psycho-social intervention consisting of multi-family communities in order to maintain long-term abstinence from alcohol and to change their lifestyle and behavior. Thus, in the present paper we were interested in understanding the demographics of this systemic theory and how these aspects are influencing the final results of the therapy, as well as studying/confirming how relevant is this systemic approach on the management of alcohol dependence. Our results presented in this report bring additional evidences for the superiority of the systemic, multi-family approach of alcohol-related problems, as complemented to the standard medicinal therapy. Moreover, the data collected from patients in this study might suggest that patients with a higher educational level and therefore better capacity of understanding the information, with family support, and also with a better occupational insertion, have accepted to follow The Clubs of Alcoholics in Treatment program, with a subsequently better evolution.
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