Supportive Care In Cancer[JOURNAL]
Sun
200 papers
Feasibility and preliminary effects of mhealth supportive care interventions in adults with myeloid neoplasms: a systematic review.
Chen K, Gou C, Wu Z … +1 more , Guo L
Support Care Cancer · 2026 Jun · PMID 42287545 · Publisher ↗
PURPOSE: Mobile health (mHealth) supportive care interventions have the potential to address the complex supportive care needs of adults with myeloid neoplasms (MNs); however, existing evidence remains fragmented, limiti...
PURPOSE: Mobile health (mHealth) supportive care interventions have the potential to address the complex supportive care needs of adults with myeloid neoplasms (MNs); however, existing evidence remains fragmented, limiting meaningful interpretation and clinical application. This systematic review aimed to synthesize the feasibility and preliminary effects of mHealth supportive care interventions for adults with MNs. METHODS: PubMed, Embase, Web of Science, and the Cochrane Library were searched from inception to November 18, 2025. Studies examining patient-facing mHealth supportive care interventions in adults with MNs were included. Given the heterogeneity in study design, intervention functions, and outcome operationalization, a structured narrative synthesis was conducted. Feasibility and preliminary effects were synthesized narratively. Methodological quality was assessed using the Mixed Methods Appraisal Tool (MMAT). RESULTS: Sixteen reports from 11 studies were included. MMAT scores ranged from 40 to 100% (median 80%). mHealth supportive care interventions were classified into four predefined functional domains: medication adherence and clinical monitoring; psychological support; value-based goal setting and self-efficacy support; and exercise rehabilitation support. Overall, mHealth supportive care interventions showed generally favorable but variable feasibility. Preliminary effects differed across these domains, with observed benefits tending to align with the primary supportive care function of each intervention. CONCLUSION: mHealth supportive care interventions for adults with MNs appear feasible and show domain-specific signals of benefit, although the evidence base remains small, unevenly distributed across domains, and preliminary. The function-oriented perspective proposed in this review may offer a useful lens for synthesizing and interpreting evidence on mHealth supportive care interventions.
Effectiveness of virtual delivery of cancer education for patients: a systematic review.
Mascan B, Sferrazza D, Zhang B … +11 more , Csaki M, Rembielak A, Szumacher E, Goh P, Patel P, Alkhafi M, Lee SF, Raman S, Rivlin L, Chow E, Wong HCY
Support Care Cancer · 2026 Jun · PMID 42287464 · Publisher ↗
BACKGROUND: Patient education is critical to effective cancer care; however, many patients experience unmet informational needs due to a lack of accessible, reliable, and comprehensible resources. Virtual education progr...
BACKGROUND: Patient education is critical to effective cancer care; however, many patients experience unmet informational needs due to a lack of accessible, reliable, and comprehensible resources. Virtual education programs have emerged as a promising approach to help patients gain information about their condition. This systematic review with narrative synthesis aims to evaluate the effectiveness of virtual cancer education in terms of knowledge translation and patient satisfaction. METHODS: A comprehensive literature search was conducted using Ovid MEDLINE, Embase, Cochrane, Web of Science, and CINAHL databases from database inception to April 2025. Studies were screened and data were extracted by two independent reviewers (B.M. and D.S.). Studies that evaluated knowledge translation and patient satisfaction with the virtual intervention were included. RESULTS: The search identified 454 studies, of which 21 met the inclusion criteria, including 10 randomized controlled trials. The virtual interventions primarily focused on educating patients about their disease and anti-cancer treatment options, with 17 studies (81%) using web-based interventions, and the remaining studies were delivered via phone, email, or text messaging. Seventeen (81%) studies reported a positive impact of virtual education on knowledge translation, with 9 reporting increased self-efficacy, 3 demonstrating improved informed decision-making, and 3 showing enhanced patient participation during medical consultations. By contrast, 3 studies (14.3%) found no significant effect on knowledge translation. Nine studies (42.9%) provided additional information on psychosocial impact, revealing overall positive effects on emotional well-being and reduced distress. Fourteen studies (67%) reported high patient satisfaction with the virtual intervention, while 6 (28.6%) suggested room for improvement in usability and design. CONCLUSION: Virtual education effectively enhances cancer-specific knowledge and is generally well-received by patients, providing a valuable alternative to in-person sessions. However, variability in outcomes highlights the need for further research into the development of personalized, interactive, and comprehensive approaches to optimize virtual education programs.
Mapping the literature on breast cancer and spirituality: emerging trends and thematic evolution in a 25-year bibliometric analysis.
Hançer AT, Demirel BR, Kılıncarslan GT
Support Care Cancer · 2026 Jun · PMID 42287448 · Publisher ↗
PURPOSE: The absence of a comprehensive bibliometric mapping study addressing breast cancer and spirituality in the literature constitutes a significant gap. Therefore, this study aims to examine research on spirituality...
PURPOSE: The absence of a comprehensive bibliometric mapping study addressing breast cancer and spirituality in the literature constitutes a significant gap. Therefore, this study aims to examine research on spirituality in breast cancer from a bibliometric perspective, identify current research trends, illustrate the conceptual evolution of the field, and provide a guiding framework for future research. METHODS: This retrospective bibliometric study analyzed publications on breast cancer and spirituality indexed in the Scopus database between 2000 and August 2025. Bibliometric analyses were conducted using the Bibliometrix package in R and VOSviewer to examine publication trends, citation patterns, collaboration networks, and thematic evolution across 470 eligible articles. RESULTS: The United States emerged as the leading contributor in terms of research productivity and citation impact, while countries such as Brazil and Portugal demonstrated notable roles within international collaboration networks. Psycho-Oncology was identified as the most influential journal in this research area, followed by Supportive Care in Cancer. The University of California system was the most prolific institution, and Gall TL was identified as the most prominent author in the field. Thematic analyses revealed a clear progression from early conceptual explorations toward more practice-oriented topics, including spiritual care, spiritual well-being, coping strategies, resilience, quality of life, and the expanding role of nursing and oncology nursing. Recent trends also indicate increasing attention to family caregivers and unmet spiritual needs. CONCLUSION: This study provides valuable guidance for researchers, academics, and clinical healthcare professionals seeking to strengthen evidence-based spiritual care in oncology settings. The literature on breast cancer and spirituality has expanded substantially over the past 25 years, with a clear shift toward applied and intervention-focused research relevant to clinical practice. Nevertheless, geographic disparities and limited representation from under-resourced regions remain evident. Future research should prioritize inclusive, interdisciplinary, and methodologically rigorous approaches to facilitate the integration of spiritual care into routine clinical practice and to advance holistic, patient-centered breast cancer care.
Impact of prophylactic skin toxicity management on treatment continuity and clinical outcomes in EGFR-mutant non-small cell lung cancer treated with osimertinib: a 7-year real-world retrospective cohort study.
Khongyot T, Melgo MNB, Nurat R … +10 more , Chanthachot M, Kochasen R, Homkaen W, Longakit RZ, Sunphakorn C, Detkaew N, Biswas M, Srikaew P, Dejrattanawichai S, Majam T
Support Care Cancer · 2026 Jun · PMID 42287425 · Publisher ↗
INTRODUCTION: Osimertinib is the preferred epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with EGFR-mutant non-small cell lung cancer (NSCLC) due to its superior efficacy and favorable...
INTRODUCTION: Osimertinib is the preferred epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with EGFR-mutant non-small cell lung cancer (NSCLC) due to its superior efficacy and favorable safety profile. Nevertheless, dermatologic toxicities remain common and may disrupt treatment continuity, underscoring the importance of effective supportive care. Evidence regarding the clinical impact of proactive skin toxicity management during osimertinib therapy in real-world settings remains limited. AIM: To evaluate the association between proactive versus reactive skin toxicity management and toxicity severity, treatment modification, and clinical outcomes in patients with EGFR-mutant NSCLC treated with osimertinib. METHODS: This retrospective cohort study included adult patients with advanced or recurrent EGFR-mutant NSCLC who received osimertinib at Surat Thani Hospital between January 2019 and January 2026. Patients were classified into a proactive skin toxicity management group, in which supportive skin care was initiated at the start of osimertinib therapy, or a reactive management group, in which skin toxicity management was initiated after the onset of dermatologic adverse events. Skin toxicities were graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0, and tumor response was assessed using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Multivariate logistic regression was used to evaluate the associations between skin toxicity management strategy (proactive vs reactive) and skin toxicity severity, osimertinib treatment modification, and objective response rate. Progression-free survival (PFS) was analyzed using Kaplan-Meier methods and Cox proportional hazards models. RESULTS: A total of 120 patients were included (60 per group), with comparable baseline characteristics. The overall incidence of skin toxicity did not differ between the proactive and reactive management groups (60.0% vs 53.3%, p = 0.290). However, proactive management was independently associated with a substantially lower risk of severe skin toxicity (adjusted odds ratio [OR] 0.122; 95% confidence interval [CI] 0.022-0.681; p = 0.006). Temporary and permanent treatment discontinuations due to skin toxicity were significantly reduced in the proactive group (both p < 0.001). Patients receiving proactive management demonstrated a higher objective response rate (78.3% vs 38.3%; adjusted OR 5.640; p < 0.001) and longer median PFS (14.0 vs 10.0 months; hazard ratio 0.313; 95% CI 0.163-0.600; p < 0.001). CONCLUSION: Proactive skin toxicity management during osimertinib therapy does not reduce the incidence of dermatologic adverse events but significantly mitigates toxicity severity, improves treatment continuity, and is associated with superior clinical outcomes compared with reactive management. These findings highlight the clinical value of proactive, supportive care-oriented skin management strategies to optimize osimertinib treatment in routine oncology practice.
Differences in perceptions of hematologists and palliative care physicians regarding transfusion therapy in patients with terminal hematological malignancies: a nationwide cross-sectional questionnaire survey in Japan.
Hattori Y, Matsumoto Y, Kosugi K … +8 more , Uehara Y, Terada T, Ge H, Akebo H, Ashitomi Y, Takeuchi M, Hashimoto C, Miura T
Support Care Cancer · 2026 Jun · PMID 42287319 · Publisher ↗
PURPOSE: To examine differences in perceptions between hematologists (HOs) and palliative care physicians (PCs) regarding red blood cell transfusion at the end of life. METHODS: This cross-sectional questionnaire survey,...
PURPOSE: To examine differences in perceptions between hematologists (HOs) and palliative care physicians (PCs) regarding red blood cell transfusion at the end of life. METHODS: This cross-sectional questionnaire survey, conducted from August to September 2020, included responses from 1000 hematologists (HOs) and 759 palliative care physicians (PCs). The questionnaire assessed cutoff indications and opinions regarding red blood cell transfusion for anemia due to hematologic malignancy progression in patients with no indication for anticancer therapy. We defined a consensus Hb threshold as the highest level at which ≥ 70% of respondents would transfuse. RESULTS: Of 659 responses, 596 were valid (269 HOs and 327 PCs). For symptomatic cases, > 70% of HOs and PCs considered Hb cutoffs of 8.0 and 7.0 g/dL, respectively. For asymptomatic cases, < 70% of PCs recommended transfusion even at Hb ≤ 6.0 g/dL; therefore, an Hb cutoff for PCs could not be determined. Most HOs and PCs agreed to reduce transfusion frequency, while PCs were more likely than HOs to agree to discontinue transfusion. In contrast, HOs were more likely than PCs to agree to continue transfusion upon patient and/or family request and to consider patients with performance status 4 eligible for transfusion. CONCLUSION: Among adult patients with hematological malignancies who have no indication for anticancer therapy, hematologists tend to view transfusion more favorably and to transfuse more actively than palliative care physicians. Greater mutual understanding and consensus-building regarding transfusion indications at the end of life may facilitate appropriate palliative care referral for these patients.
TAR-0520, a new candidate in oncodermatology: Results of a phase 1 program in healthy volunteers.
Andres P, Winckle G, Lamquin A … +1 more , Czernielewski J
Support Care Cancer · 2026 Jun · PMID 42283933 · Full text
PURPOSE: TAR-0520 gel is a new topical formulation of brimonidine tartrate designed to prevent chemotherapy-induced skin toxicities. We report here the main outcomes of the phase 1 program which included two double-blind...
PURPOSE: TAR-0520 gel is a new topical formulation of brimonidine tartrate designed to prevent chemotherapy-induced skin toxicities. We report here the main outcomes of the phase 1 program which included two double-blind, randomized trials in healthy volunteers (TAR006 and TAR012) and were performed to evaluate the safety, local tolerability, pharmacokinetics, and pharmacodynamics (PD) of TAR-0520 gel. METHOD: In TAR006, participants received four concentrations of TAR-0520 gel (0.5%, 0.75%, 1% and 1.5% of Brimonidine tartrate), placebo, or active comparator (Mirvaso® Galderma International, France) applied daily to the chest for 21 days, while TAR012 evaluated TAR-0520 gel 1% and 1.5% on the chest and face over the same duration. Local tolerance was assessed daily in both studies using mean cumulative irritation index and maximum irritation score as key endpoints. Skin blanching was assessed via chromameter-measured reductions in skin redness as a marker of vasoconstriction and product potency. In TAR006, systemic exposure to brimonidine tartrate was assessed from blood samples collected in a separate cohort treated with TAR-0520 gel 1%. RESULTS: Overall, 28 participants were randomized in TAR006 and 26 were randomized in TAR012. Both studies showed excellent local tolerance with 50 healthy volunteers reporting no evidence of irritation with any treatment and four patients reporting barely perceptible minimal erythema. No adverse events related to TAR-0520 gel were reported. Minimal systemic absorption was observed that was not considered to be clinically relevant. PD studies indicated dose-dependent vasoconstriction with once-daily use lasting over 24 h. CONCLUSION: Under the conditions of these studies, TAR-0520 gel presents a very favorable safety profile with little to no local irritation and insignificant systemic exposure. Allowing a superficial skin vasoconstriction over a period of 24 h, it offers a safe, patient-friendly, and adaptable topical solution. The 1.5% concentration was selected for further development and phase II trials for managing chemotherapy-related skin toxicities are in progress. REGISTRATION DETAILS: - TARIAN 006, 2023-504178-39-00 approved 24/08/203. - TARIAN 012, 2324CMCL096 approved 28/05/2024.
"Don't be a hero, don't keep it a secret": understanding the lived experience of Chinese American patients with cancer through their expressive writing entries.
Chebli P, Kranick J, Mazor M … +7 more , Estrada WM, Mui A, Foster V, Kwon SC, Ngo V, Trinh-Shevrin C, Tsai W
Support Care Cancer · 2026 Jun · PMID 42283914 · Full text
PURPOSE: Cancer is the leading cause of death for Chinese Americans, and research on optimal psychosocial interventions is scarce. Understanding the specific experiences of Chinese Americans with cancer is essential for...
PURPOSE: Cancer is the leading cause of death for Chinese Americans, and research on optimal psychosocial interventions is scarce. Understanding the specific experiences of Chinese Americans with cancer is essential for developing supportive interventions. This study is a qualitative analysis of patient narratives collected from an Expressive Helping intervention, obtained from Chinese Americans with cancer to explore their experiences and meaning making of their cancer diagnosis and treatment journeys. METHODS: Thirty-one participants completed four 20-min writing sessions related to their cancer experiences. Informed by the Common-Sense Model of illness self-regulation, we used iterative, blended deductive-inductive coding and conducted a thematic analysis to explore meaning making, illness perception/narrative, and peer-helping recommendations. RESULTS: Significant themes were identified at the intrapersonal, interpersonal, and organizational/community levels. Participants felt initial disbelief and distress at the cancer diagnosis, which were attenuated through reframing of their experiences and finding support from various sources. Participants were also worried about burdening their families with their diagnosis but subsequently came to appreciate their support. They described challenges with navigating the healthcare system but appreciated having access to trusted providers and modern medicine. Patients also provided advice to support other patients on their cancer journey. CONCLUSION: Understanding the factors that influence the mental health of patients with cancer and survivors is key to informing responsive supportive strategies. Our analysis of expressive writing narratives by Chinese Americans with cancer illuminates their unique challenges and myriad ways they find resilience and acceptance.
Social inequalities in return-to-work among colorectal cancer survivors in Germany.
Soff J, Demirer I, Sibert NT … +11 more , Breidenbach C, Ernstmann N, Heidkamp P, Heier L, Hiltrop K, Schellack SK, Weiß J, Rick O, Benz SR, Dragano N, Kowalski C
Support Care Cancer · 2026 Jun · PMID 42283908 · Full text
BACKGROUND: For working-age patients with colorectal cancer, returning to work is a key rehabilitation goal. This study examines the association between socio-economic position (SEP) and return-to-work (RTW), including c...
BACKGROUND: For working-age patients with colorectal cancer, returning to work is a key rehabilitation goal. This study examines the association between socio-economic position (SEP) and return-to-work (RTW), including competing outcomes (pension entry and death), following medical rehabilitation. METHODS: German Pension Insurance data (2013-2022) were analysed, including 32,174 formerly employed patients (ICD-10 C18-C20) of working age undergoing oncological rehabilitation. Patients were categorised by SEP (education, occupational position, income). Logistic regression and restricted mean survival time (RMST) analyses investigated socio-economic differences in RTW, unemployment, sick leave, pension, and death. RESULTS: Following rehabilitation, 31% of patients returned to work in the first month, and by 2 years, 65% had experienced a long-term RTW lasting ≥ 6 months. SEP was significantly associated with both initial and long-term RTW. The strongest associations were observed for income (long-term RTW highest vs. lowest income tertile: adjusted odds ratio [aOR] 3.06; 95% CI 2.84-3.31) and university education (long-term RTW ISCED‑2011 levels 5-8 vs. 1-3: aOR 2.20; 95% CI 1.94-2.50). RMST showed that patients with higher SEP spent more time in employment and less time unemployed or receiving disability pension than those with lower SEP. The employment time lost between the highest and lowest SEP levels was 8 months for education, 8 months for occupational position, and 10 months for income. CONCLUSIONS: Fifty-eight percent of patients with colorectal cancer were stably employed 2 years after medical rehabilitation. However, despite universal access to rehabilitation in Germany, strong social inequalities in RTW were observed. Monthly employment and pension data allowed reliable estimates, preventing selective non-response and recall bias. However, the results might not generalise to those who do not undergo rehabilitation.
Classifying family resilience trajectory of patients undergoing lung cancer surgery: a longitudinal study.
Gao SR, Zhu J, Yan H … +5 more , Xu H, Wu XY, Luo GH, Li XT, Ye M
Support Care Cancer · 2026 Jun · PMID 42283863 · Publisher ↗
BACKGROUND: Lung cancer creates significant challenges for patients and families. Surgery and recovery bring heavy physical and psychological burdens. Family resilience, the ability to adapt and recover from crises, is v...
BACKGROUND: Lung cancer creates significant challenges for patients and families. Surgery and recovery bring heavy physical and psychological burdens. Family resilience, the ability to adapt and recover from crises, is vital for coping. However, current research is mostly cross-sectional and fails to reveal how family resilience changes over time. This study aims to identify the distinct trajectories and predictors of family resilience in lung cancer patients undergoing surgery. AIM: To identify trajectories of family resilience and their predictors in lung cancer surgery patients. METHODS: This longitudinal study initially enrolled 442 patients, with 381 completing follow-up at 2 weeks (T1) and 3 months (T2). Socio-demographic and clinical data were collected at baseline (T0). Family resilience, psychological resilience, and perceived social support were assessed at all three time points. K-means clustering and multinomial logistic regression were used to identify trajectories and predictors. STROBE guidelines were followed. RESULTS: Three trajectories emerged: Cluster A (28.9%, high baseline with a rapid decline), Cluster B (42.3%, moderate baseline with a gradual decline), and Cluster C (28.9%, low baseline with a slight rise and a following decline). Predictors of Cluster A included male gender, no comorbidities, and greater psychological and perceived social support. Older age (51-60) and low income (< 1000 RMB) predicted Cluster B. Middle income (1000-5000 RMB) and no family cancer history predicted Cluster C. CONCLUSION: Family resilience showed three distinct trajectories. Males without comorbidities and with greater perceived social support had higher family resilience. Females, middle-income households, no cancer family history, and low perceived social support were linked to low family resilience. Early nursing intervention is essential for at-risk families.
Development and practice of a standardized management pathway for chemotherapy-induced neutropenia in patients with gynecological malignancies.
Dan X, Tian Y, Yin R … +5 more , Song L, Li S, Chen L, Huang Y, He Y
Support Care Cancer · 2026 Jun · PMID 42277458 · Publisher ↗
BACKGROUND: Chemotherapy-induced neutropenia (CIN) is the most common type of myelosuppression in patients undergoing chemotherapy. It can lead to chemotherapy dose reduction, treatment delays, diminished antitumor effic...
BACKGROUND: Chemotherapy-induced neutropenia (CIN) is the most common type of myelosuppression in patients undergoing chemotherapy. It can lead to chemotherapy dose reduction, treatment delays, diminished antitumor efficacy, reduced quality of life, and increased healthcare burden. Although various guidelines have been established domestically and internationally to standardize the management of CIN, their effectiveness in controlling its incidence remains limited. PURPOSE: This study aimed to evaluate the role of a standardized management pathway in the management of CIN and its impact on chemotherapy-related adverse events and satisfaction among gynecological cancer patients. METHODS: A total of 230 patients receiving conventional management from July to December 2024 were selected as the control group, while 230 patients managed under the CIN standardized pathway from January to June 2025 were enrolled as the intervention group. The CIN standardized management pathway integrated functions such as febrile neutropenia (FN) risk calculation, visual risk stratification alerts, intelligent decision support for prophylactic medication, multi-approach health education, and cloud-based follow-up. Comparisons were made between the two groups regarding hematological toxicity markers (ANC, WBC), incidence of chemotherapy-related adverse events (FN, chemotherapy delay, and dose reduction), FN risk assessment compliance rate, and patient satisfaction. RESULTS: After three chemotherapy cycles, unadjusted comparisons showed more favorable ANC and WBC distributions in the intervention group than in the control group (all P < 0.001). However, adjusted analyses did not show statistically significant associations with grade 3-4 ANC reduction or grade 3-4 WBC reduction. The FN risk-assessment compliance rate reached 100% in the intervention group, higher than the 54.6% observed in the control group (P < 0.001). The observed incidence of FN was lower in the intervention group than in the control group (1.4% vs. 8.3%; P = 0.002), although FN was analyzed descriptively. The intervention was associated with lower adjusted odds of chemotherapy delay and dose reduction and with higher adjusted patient satisfaction scores. CONCLUSION: The standardized CIN management pathway was associated with favorable changes in hematologic toxicity indicators, chemotherapy-related adverse events, and patient satisfaction. Further multicenter randomized or cluster-randomized studies are needed to confirm these findings.
Treatment-related pain in refractory cancer pain: prevalence, mechanisms, and clinical implications in a tertiary referral cohort.
Agur R, Cohen B, Sabbah M … +5 more , Brill S, Staierman M, Goldsmith D, Khashan M, Hochberg U
Support Care Cancer · 2026 Jun · PMID 42277447 · Full text
BACKGROUND: The long-term effects of cancer treatment are increasingly driving persistent pain in cancer survivors; however, the contribution and clinical profile of cancer treatment-related pain (CTRP) in refractory pai...
BACKGROUND: The long-term effects of cancer treatment are increasingly driving persistent pain in cancer survivors; however, the contribution and clinical profile of cancer treatment-related pain (CTRP) in refractory pain populations remain poorly defined. METHODS: We conducted a retrospective cohort study of consecutive patients (N = 622) referred to a tertiary multidisciplinary cancer pain clinic for initial evaluation of refractory pain (January 2021-June 2025). Pain etiology was classified using ICD-11 criteria as treatment-related pain (TRP; MG30.11), tumor-related pain (MG30.10), or non-cancer-related pain. The multivariate logistic regression analysis identified factors associated with TRP attribution. RESULTS: TRP was identified in 42.1% of patients (n = 262). Patients with TRP were younger than those with tumor-related pain (mean 58.1 ± 14.8 vs 64.2 ± 12.8 years, p < 0.001). Peripheral neuropathy was strongly associated with TRP attribution (adjusted odds ratio 9.18; 95% CI 2.56-32.83). Neuropathic (46.2%) and mixed (35.9%) mechanisms predominated in TRP, whereas nociceptive mechanisms were more common in tumor-related pain. CONCLUSIONS: Treatment-related pain constitutes a major component of refractory cancer pain and demonstrates a distinct clinical and mechanistic profiles. Its predominance among younger survivors supports its characterization as a survivorship-associated morbidity rather than an end-of-life phenomenon. These findings support the earlier recognition and integration of mechanism-informed, multidisciplinary supportive care strategies to improve outcomes in patients with persistent treatment-related pain.
Feasibility and acceptability of ExerciseGuideUK for those living with and beyond lung cancer: a mixed methods study.
Curry J, Pearson M, Short CE … +4 more , Vandelanotte C, Evans HEL, Lind M, Forbes CC
Support Care Cancer · 2026 Jun · PMID 42277446 · Full text
PURPOSE: Digital health interventions offer promise for addressing unmet needs in individuals living with and beyond lung cancer (LWBLC). ExerciseGuideUK, a personalised, web-based exercise platform, was developed for th...
PURPOSE: Digital health interventions offer promise for addressing unmet needs in individuals living with and beyond lung cancer (LWBLC). ExerciseGuideUK, a personalised, web-based exercise platform, was developed for those LWBLC. This study aimed to evaluate ExerciseGuideUK. METHODS: Participants were recruited from Hull University Teaching Hospital and used ExerciseGuideUK over eight weeks. Feasibility and acceptability were assessed using quantitative measures, including the System Usability Scale, structured questionnaires, and qualitative interviews (guided by the Theoretical Framework of Acceptability). A novel mixed-methods integration approach called the Pillar Integration process (PIP) was used to integrate quantitative and qualitative findings on feasibility, engagement, barriers, and adaptation potential. RESULTS: Eighteen participants (mean age 65 ± 14.42y) enrolled. Recruitment and retention rates were 30.5% and 77%, respectively. Notably, 25.4% of those screened were excluded due to digital access issues, including some participants who owned smartphones, suggesting limited digital literacy. Among those who participated, acceptability, usability, and engagement were high. Valued features included goal-setting tools, breathlessness management strategies, and personalised exercise prescriptions. Barriers included treatment side effects, work responsibilities, and low confidence with technology. CONCLUSION: ExerciseGuideUK showed moderate feasibility and high acceptability among users. This is the first known application of PIP in the context of lung cancer, exercise, and digital health. The PIP facilitated a comprehensive understanding of feasibility and acceptability, guiding informed adaptations by users. The PIP warrants further testing and refinement in relation to optimising digital intervention design that promotes equitable, patient-centred care. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05121259.
Assessing the impact of nutritional status at allogeneic stem cell transplantation on clinical outcomes.
Paviglianiti A, Sanchis MB, Peña M … +12 more , Martínez IP, Peña-Muñoz F, Hurtado L, Gil RL, Mussetti A, Arnan M, Pomares H, Barca EG, López P, Strollo R, Pozzilli P, Sureda A
Support Care Cancer · 2026 Jun · PMID 42277329 · Publisher ↗
PURPOSE: Nutritional status at allogeneic hematopoietic cell transplantation (HCT) can significantly impact outcomes, but conflicting results are reported. METHODS: We investigate the role of nutritional status on HCT ou...
PURPOSE: Nutritional status at allogeneic hematopoietic cell transplantation (HCT) can significantly impact outcomes, but conflicting results are reported. METHODS: We investigate the role of nutritional status on HCT outcomes in 158 patients, including diabetes, body mass index (BMI), nutritional risk index (NRI) and the patient-generated subjective global assessment (PG-SGA). RESULTS: PG-SGA was scored as A (well nourished) in 52%, B (risk of malnutrition or moderate malnutrition) in 44% and C (severely malnourished) in 4%. NRI was mild in 14 (9%), moderate in 33 (21%) and severe in 4 (3%) patients. Oral nutritional support and total parenteral nutrition was used during hospitalization in 86% and 36% patients. The cumulative incidence of grade II-IV acute graft-versus-host disease (GvHD) at 100 days was 20% (95% CI 14-27%). At 30 months, chronic GvHD was 17% (95% CI 12-24%), non-relapse mortality (NRM) was 25% (95% CI 19-33%) and relapse incidence (RI) was 24% (95% CI 18-32%). Overall survival and progression-free survival were 57% (95% CI 49-64%) and 50% (95% CI 42-58%) at 30 months. Patients with a median BMI above the median (median BMI = 25.87 kg/m2) had a lower risk of both acute (HR 0.42, 95%CI 0.12-0.92, p = 0.03) and chronic (HR 0.42, 95%CI 0.19-0.90, p = 0.02) GvHD in multivariate analysis. No statistical differences were found according to PG-SGA and NRI. CONCLUSIONS: Our findings highlight the critical role of pre-transplant metabolic evaluation, personalized nutritional support, and optimal glycemic regulation in HCT care. Further large-scale studies are required to determine the association between nutritional status and HCT outcomes.
Associations of symptom burden with patient-reported outcomes and clinical outcomes among early phase cancer clinical trial participants.
Lam AB, Pelletier A, Durbin SM … +14 more , Lynch K, Petrillo LA, Jimenez R, Boulanger M, Moore C, Thompson L, Bame V, Yalala V, Ollila N, Malowitz B, McIntyre C, Juric D, Lundquist D, Nipp RD
Support Care Cancer · 2026 Jun · PMID 42274780 · Publisher ↗
PURPOSE: Individuals with cancer often endure a substantial symptom burden. However, little is known about the symptom burden of patients with cancer participating in early phase cancer clinical trials (EPCT). METHODS: W...
PURPOSE: Individuals with cancer often endure a substantial symptom burden. However, little is known about the symptom burden of patients with cancer participating in early phase cancer clinical trials (EPCT). METHODS: We prospectively enrolled adults with cancer participating in EPCTs at Massachusetts General Hospital from 4/2021-1/2023. Participants completed surveys prior to EPCT initiation that assessed symptoms (Edmonton Symptom Assessment System [ESAS]), quality of life (QOL; Functional Assessment of Cancer Therapy-General), depression/anxiety symptoms (Patient Health Questionnaire-4), and financial well-being (COST). We used regression models to explore associations of symptom burden with patient-reported outcomes and clinical outcomes. RESULTS: Among 195 patients enrolled, 185 participants completed the surveys (94.9% response rate). Participants had a median age of 63.5 years (range: 31.8-88.6) and 57.3% were female. Most common cancer types were gastrointestinal and breast. Median survival was 7.82 (IQR: 3.88-18.71) months, and median follow-up time was 12.20 (IQR: 7.99-16.80) months. Participants reported moderate/severe fatigue (51.7%), poor well-being (49.7%), drowsiness (36.2%), pain (26.4%), and lack of appetite (25.8%). Higher ESAS-total scores and greater number of moderate/severe symptoms were associated with lower QOL, increased depression/anxiety symptoms, and worse financial well-being (p-values < 0.05 for all). Higher ESAS-total scores (HR:1.02, p < 0.001) were associated with worse overall survival. CONCLUSION: Among EPCT participants, higher symptom burden at time of clinical trial initiation correlated with decreased QOL, increased depression/anxiety symptoms, worse financial well-being, shorter time on trial, and worse overall survival. Interventions seeking to enhance care delivery and outcomes for EPCT participants should strive to address the symptom burden of this population.
Does the Edmonton Symptom Assessment Scale rule in or rule out anxiety and depression?
Davis MP
Support Care Cancer · 2026 Jun · PMID 42274773 · Publisher ↗
Abstract loading — click title to view on PubMed.
The relationship between quality of life and spiritual fortitude in individuals with an intestinal stoma.
Güney A, Ordu Y, Alabay KNK
Support Care Cancer · 2026 Jun · PMID 42274771 · Full text
PURPOSE: This study aims to examine the relationship between quality of life and spiritual fortitude in individuals with an intestinal stoma. METHODS: This descriptive and correlational study was conducted with 66 indivi...
PURPOSE: This study aims to examine the relationship between quality of life and spiritual fortitude in individuals with an intestinal stoma. METHODS: This descriptive and correlational study was conducted with 66 individuals with an intestinal stoma between November 2024 and May 2025. Data were collected face-to-face in a hospital setting using the "Descriptive Characteristics Form," the "Stoma Quality of Life Scale," and the "Spiritual Fortitude Scale." Data were analyzed using SPSS 22.0, and p < 0.05 was considered statistically significant. RESULTS: The participants had a mean age of 61.71 ± 13.90 years; 53% were women, and 45.5% were primary school graduates. The mean total score for Stoma Quality of Life Scale was 52.21 (SD = 8.21), and the mean total score for Spiritual Fortitude was 33.79 (SD = 8.20). There was a significant association between the spiritual fortitude of individuals with an intestinal stoma and their quality of life (β = 0.261, R = 0.261, p = 0.035). CONCLUSION: Nurses can provide spiritual counseling services to enhance the spiritual fortitude of individuals with an intestinal stoma. Future research should focus on nurses' competencies in spiritual counseling and the effectiveness of such services.
Multinational Association of Supportive Care in Cancer (MASCC) endorsement and global perspectives on implementation of the American Society of Clinical Oncology and Society of Integrative Oncology (ASCO-SIO) fatigue in adult cancer survivors guideline.
Kleckner AS, Agbejule OA, Al-Harrasi A … +10 more , Escalante CP, Keane P, Lin PJ, Molassiotis A, Mustian KM, Potter L, Prue G, Singh Uppal R, Whitehead M, Hart NH
Support Care Cancer · 2026 Jun · PMID 42268440 · Publisher ↗
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A mixed-method study of identifying symptom clusters in adult patients with advanced cancer.
Miladinia M, Zarea K, Gheibizadeh M … +3 more , Jahangiri M, Karimpourian H, Rokhafroz D
Support Care Cancer · 2026 Jun · PMID 42268436 · Publisher ↗
PURPOSE: This study aimed to identify symptom clusters (SCs) in adults with advanced cancer using a mixed-method approach. METHODS: This parallel mixed-method study was conducted in academic cancer care centers in Ahvaz,...
PURPOSE: This study aimed to identify symptom clusters (SCs) in adults with advanced cancer using a mixed-method approach. METHODS: This parallel mixed-method study was conducted in academic cancer care centers in Ahvaz, Iran. In the quantitative phase, 640 patients completed the Memorial Symptom Assessment Scale, and SCs were extracted using hierarchical cluster analysis with dendrogram and heatmap visualization. In the qualitative phase, 24 semi-structured interviews were conducted with 18 participants, and data were analyzed using conventional content analysis. Integration followed Creswell's approach through simultaneous comparison and joint display of findings. A multidisciplinary expert panel guided the data merging process. RESULTS: Quantitative analysis identified six clusters: gastrointestinal problems, appearance changes, respiratory issues, psychoneurological symptoms, mind-body symptoms, and hormonal. Qualitative analysis revealed seven clusters: mind-body symptoms, respiratory issues, appearance changes, psychoneurological symptoms, gastrointestinal problems, psychosocial symptoms, and spiritual-emotional symptoms. Integration led to eight final clusters. Five clusters were identified by both methods, mutually reinforcing and complementing one another. The hormonal cluster was exclusive to quantitative analysis, while psychosocial and spiritual-emotional clusters emerged only through qualitative analysis. Symptoms such as lack of energy, difficulty sleeping, worrying, feeling sad, and feeling nervous appeared across multiple clusters and were identified as overlapping (bridge) symptoms. CONCLUSION: The mixed-method approach enabled a multidimensional understanding of SCs in advanced cancer, allowing for both confirmation and expansion of findings. This study facilitates effective symptom management through the identification of SCs. Recognizing bridge symptoms offers key targets for intervention, with potential to impact multiple clusters simultaneously.
Patient-reported and caregiver-reported outcomes after limb salvage or amputation for pediatric bone and soft tissue sarcomas: a scoping review.
Jibb L, Feliciano J, Zaffino I … +5 more , Palmert T, Gray M, Hashemi E, Deans E, Deans L
Support Care Cancer · 2026 Jun · PMID 42268432 · Full text
PURPOSE: Children diagnosed with bone tumors or soft tissue sarcomas often undergo limb salvage surgery or amputation, procedures that shape long-term functioning and quality of life (QOL). Patient-reported and caregiver...
PURPOSE: Children diagnosed with bone tumors or soft tissue sarcomas often undergo limb salvage surgery or amputation, procedures that shape long-term functioning and quality of life (QOL). Patient-reported and caregiver-reported outcomes (PROs) provide essential insight into physical, psychosocial, and participation impacts, yet existing evidence is dispersed and methodologically heterogeneous. This scoping review mapped the PRO literature for children, survivors, and caregivers following cancer-related limb surgery and identified gaps limiting clinical care and research advancement. METHODS: Six databases were searched. Eligible studies included children with bone or soft-tissue sarcomas and their family caregivers that reported PROs or needs related to limb salvage or amputation. Two reviewers independently screened studies and charted data. Quantitative and qualitative findings were summarized descriptively and synthesized narratively across QOL domains. RESULTS: Twenty-seven studies fulfilled inclusion criteria. Physical functioning was the most assessed domain, with generally moderate-to-good outcomes and limited differences between limb salvage and amputation. Pain remained common months to years post-surgery. Psychosocial findings were mixed, reflecting peer acceptance but also body image, recreation, and school participation challenges. Only four studies included caregivers, who reported anxiety, depression, financial strain, and shifting family roles. Across studies, PRO measurement was highly heterogeneous, with inconsistent domains of assessment, measurement tool use, and timepoints. CONCLUSIONS: Children and families experience complex functional and psychosocial impacts after limb surgery, underscoring needs for enhanced rehabilitation, pain care, school reintegration, and caregiver support.
Oral microbiota associated with radiation-related caries among nasopharyngeal carcinoma patients following radiation therapy: analysis based on a longitudinal study.
Zhang W, Chen W, Zhao L … +5 more , Li X, Li Q, Hao X, Su Y, Zou L
Support Care Cancer · 2026 Jun · PMID 42265469 · Publisher ↗
PURPOSE: The study aimed to characterize the oral microbiota of patients with nasopharyngeal carcinoma (NPC) before and after radiotherapy (RT), and to compare the differences in microbiota between patients with and with...
PURPOSE: The study aimed to characterize the oral microbiota of patients with nasopharyngeal carcinoma (NPC) before and after radiotherapy (RT), and to compare the differences in microbiota between patients with and without radiation-related caries (RRC). METHODS: Saliva and tongue swab samples were collected from 29 NPC patients pre-RT (baseline) and 3-9 months post-RT. Patients were categorized into the RRC group (those who developed new radiation-related caries post-RT) or the non-RRC group (those without new caries) based on clinical diagnosis. Oral microbiota composition was assessed via 16S rRNA gene sequencing. The permutational multivariate analysis of variance (PerMANOVA) and linear discriminant analysis (LDA) effect size (LEfSe) were used to compare the oral microbiota composition before and after RT and between patients with and without RRC after RT. RESULTS: There were no significant differences in alpha diversity between patients before and after RT, nor between the RRC and non-RRC groups after RT. The beta diversity analyses detected significant differences on post-RT saliva samples between the RRC and non-RRC groups (R = 0.062, F = 1.720, P = 0.005). There were also significant differences in the beta diversity of both saliva samples (R = 0.099, F = 2.192, P = 0.001) and tongue swab samples (R = 0.118, F = 2.671, P = 0.002) before and after RT in the RRC group, as well as in saliva (R = 0.062, F = 2.183, P = 0.005) and tongue swab (R = 0.099, F = 3.639, P = 0.001) samples in the non-RRC group. The LEfSe analysis showed no substantial difference when comparing microbiota composition of saliva and tongue swab samples between RRC and non-RRC groups before RT. However, an enrichment of Streptococcus mutans and Ligilactobacillus salivarius was detected post-RT in both the salivary and tongue swab samples of the RRC group. CONCLUSION: RT was associated with significantly altered oral microbiota composition of NPC patients, while RRC was associated with tooth decay related microbiota enrichment after RT.
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