Alanazi R, Alshammari S, Aldossari K
… +6 more, Alwatban R, Aljeribah D, Alanazi S, Alsalhi A, Alhumam A, Alajlan A
J Cosmet Dermatol
· 2026 Apr · PMID 41954038
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BACKGROUND: Hair loss is a common condition affecting both men and women, with significant psychosocial impact. While oral supplements are marketed to improve hair growth, their clinical efficacy remains debated. This sy...BACKGROUND: Hair loss is a common condition affecting both men and women, with significant psychosocial impact. While oral supplements are marketed to improve hair growth, their clinical efficacy remains debated. This systematic review aimed to evaluate the effectiveness and safety of commercial oral nutraceuticals for hair growth. METHODS: For this systematic review, a comprehensive search was undertaken in PubMed, Embase, Cochrane CENTRAL, and Web of Science. Eligible studies included randomized controlled trials (RCTs), open-label trials, and proof-of-concept studies evaluating oral supplements in adults (≥ 18 years) with alopecia or hair thinning. Primary outcomes included objective measures including hair counts, density, growth rate, tensile strength, and pull test. Secondary outcomes were investigator/patient assessments and adverse events. RESULTS: A total of 14 studies, including 967 participants, were included. Supplements assessed included Ceramosides, Nutrafol, Nourkrin, Lambdapil, Viviscal, Forti5, GFM oral supplement, and Cynatine HNS. Most trials were RCTs with durations of 12 weeks to 12 months. Meta-analysis demonstrated significant improvements with oral supplements versus placebo: reduced telogen hair density (mean difference [MD] -5.91, 95% confidence interval [CI] -6.74 to -5.08, p < 0.00001), increased anagen hair density (MD 10.48, 95% CI: 8.81 to 12.14, p < 0.00001), and reduced telogen proportion (MD 3.08, 95% CI: -3.35 to -2.81, p < 0.00001). Similarly, significant differences were observed regarding anagen proportion, elongation, and hairs extracted on a pull test (p < 0.00001 for all). Total hair count showed no significant difference (p = 0.06). Patient-reported outcomes consistently favored supplements, reporting improved thickness, reduced shedding, and better satisfaction. Adverse events were minimal, and safety profiles were favorable. CONCLUSIONS: In conclusion, supplements show promising preliminary results, but more rigorous, independent research is needed to confirm these findings.
Liu Y, Fang M, Xu Y
… +7 more, Wang M, Dou M, Zhang Y, Li S, Dou J, Zhang W, Wang L
J Cosmet Dermatol
· 2026 Apr · PMID 41952560
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PURPOSE: Treatment of early post-traumatic scars with energy-based devices like plasma radiofrequency is often complicated by post-inflammatory hyperpigmentation (PIH). This study aimed to evaluate the efficacy and safet...PURPOSE: Treatment of early post-traumatic scars with energy-based devices like plasma radiofrequency is often complicated by post-inflammatory hyperpigmentation (PIH). This study aimed to evaluate the efficacy and safety of a combination regimen of plasma radiofrequency and immediate topical application of tranexamic acid (TXA) to simultaneously address both scars and concomitant PIH. METHODS: This retrospective study included 35 patients with early post-traumatic scars and hyperpigmentation. All patients underwent three sessions of plasma radiofrequency at 6-week intervals, each followed by immediate in-office and 7-day at-home topical application of TXA. Efficacy was evaluated using the Modified Vancouver Scar Scale (mVSS), Investigator's Global Assessment (IGA), and a patient-reported Visual Analogue Scale (VAS) for satisfaction at baseline and 6 weeks after the final session. RESULTS: Significant improvements were observed in all patients. The mean mVSS score decreased from a baseline of 5.71 ± 1.47 to 2.66 ± 2.07 at the final follow-up (p < 0.001). According to IGA, 91.4% (32/35) of patients achieved moderate to excellent improvement. High patient satisfaction was reported on the VAS. No serious adverse events were observed; side effects were limited to transient erythema and edema. CONCLUSION: The combination of plasma radiofrequency with immediate topical TXA application is a safe and effective strategy for treating early scars with hyperpigmentation. This dual-action approach successfully improves scar characteristics while controlling and reversing pigmentation, offering a valuable therapeutic option to optimize outcomes with energy-based devices.
Huang J, Chen C, Zhang M
… +5 more, Li J, Wang R, Wang Y, Zhang J, Chen Q
J Cosmet Dermatol
· 2026 Apr · PMID 41952536
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OBJECTIVE: This study aims to evaluate the effects of Fish Collagen Peptide Nutritional Combination (FCPNC) on facial skin rejuvenation and biochemical indicators, including body mass index (BMI), blood lipids, superoxid...OBJECTIVE: This study aims to evaluate the effects of Fish Collagen Peptide Nutritional Combination (FCPNC) on facial skin rejuvenation and biochemical indicators, including body mass index (BMI), blood lipids, superoxide dismutase (SOD), and bone mineral density in participants. METHODS: This study involved 29 female participants aged 20-55 years, who consumed FCPNC daily for 90 days. Facial skin changes, including wrinkle percentage, pigmentation area, skin hydration, and elasticity, were assessed before and after the intervention. Additionally, BMI, blood tests, and bone mineral density were measured on Day 0 and Day 90. Participants completed questionnaires on skin, nails, hair, and product satisfaction at Days 30, 60, and 90. RESULTS: After 30, 60, and 90 days, participants exhibited significant improvements in skin hydration, elasticity, and a reduction in wrinkle area percentage. This nutritional combination not only improved skin health but also yielded systemic benefits, including normalizing BMI in 58.33% of overweight participants. SOD activity increased by 31.03%, reflecting enhanced antioxidant capacity. Additionally, calcium levels rose by 48.28%, suggesting potential bone health benefits. Satisfaction surveys revealed increasing positive feedback, with 93% of participants rating the product favorably by the study's conclusion (score ≥ 4). CONCLUSIONS: These findings suggest that FCPNC may positively influence skin health and overall health status, emphasizing its potential as a functional food. However, further large-scale randomized controlled trials are necessary to validate these results.
Han JH, Ju HJ, Kim TI
… +7 more, Yoon YH, Woo YJ, Kye H, Kim JY, Jeong SJ, Baek E, Bae JM
J Cosmet Dermatol
· 2026 Apr · PMID 41949173
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BACKGROUND: Current acne management relies largely on topical and systemic pharmacotherapy, but these treatments frequently cause cutaneous adverse reactions. Such side effects are of particular concern in patients with...BACKGROUND: Current acne management relies largely on topical and systemic pharmacotherapy, but these treatments frequently cause cutaneous adverse reactions. Such side effects are of particular concern in patients with initial skin sensitivity, highlighting the need for personalized approaches. METHODS: This 12-week prospective observational study included 308 Korean acne patients to compare the clinical efficacy of a specific dermo-cosmetic (DC) formulation used as monotherapy versus combination therapy in acne patients, and to evaluate a sensitivity-based approach to improve quality of life. Patients were classified into DC monotherapy (n = 151) or combination therapy (n = 157), and to sensitive (n = 144) or non-sensitive (n = 164) subgroups. Primary outcomes were Global Evaluation of Acne (GEA), total lesion count, and sebum secretion levels. Secondary outcomes included skin sensitization score, tolerance assessment, quality of life, and adverse events. RESULTS: The DC monotherapy group showed significantly greater improvement in GEA scores, fewer sensitivity symptoms, improved quality of life, and greater tolerability than the combination therapy group (all p < 0.0001). In the sensitive patient subgroup, DC monotherapy was also significantly superior to combination therapy in terms of GEA, tolerability, sensitivity symptoms, and quality of life (all p < 0.0001). In patients without initial sensitivity, improvement in GEA (p = 0.0079), total lesion count (p < 0.0001), and sebum secretion (p < 0.0001) was significantly greater in the combination therapy than in the DC monotherapy. CONCLUSION: These findings suggest that baseline skin sensitivity may represent an important determinant of treatment selection and support a sensitivity-guided personalized treatment approach in acne management.
Kumar N, Suh DH, Lee SJ
… +2 more, Kasif SA, Carruthers JDA
J Cosmet Dermatol
· 2026 Apr · PMID 41947517
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BACKGROUND: Radiofrequency microneedling (RFMN) is a prominent minimally invasive treatment for facial rejuvenation. While individual studies report positive outcomes, a comprehensive synthesis of evidence across efficac...BACKGROUND: Radiofrequency microneedling (RFMN) is a prominent minimally invasive treatment for facial rejuvenation. While individual studies report positive outcomes, a comprehensive synthesis of evidence across efficacy, safety, and patient satisfaction is lacking. OBJECTIVES: To synthesize evidence on the aesthetic, safety, tolerability, and psychological outcomes of RFMN for facial rejuvenation. METHODS: We conducted this systematic review in accordance with PRISMA and JBI guidelines. We systematically searched four electronic databases (PubMed, Embase, CENTRAL, LILACS) for studies published between 2015 and 2025. We included 22 studies. We assessed risk of bias using a JBI tool and conducted a thematic synthesis of aesthetic outcomes, patient satisfaction, and safety. We evaluated confidence in the findings using the GRADE-CERQual approach. RESULTS: Our synthesis of 20 studies (558 participants) found that RFMN treatments consistently improved aesthetic outcomes, with significant improvements in skin texture and tightening supported by high Global Aesthetic Improvement Scale scores. We found a favorable safety profile, where adverse events were predominantly mild and transient (erythema and edema were most common), and no serious complications were reported. Pain was typically mild to moderate and well-tolerated. Patient satisfaction was remarkably high, with most studies reporting rates exceeding 90%, which was strongly correlated with the procedure's efficacy and minimal downtime. CONCLUSION: The synthesis of evidence indicates that RFMN is an effective and well-tolerated intervention for facial rejuvenation, characterized by robust clinical outcomes and exceptionally high patient satisfaction. These findings solidify its role as a cornerstone treatment in modern aesthetic practice. TRIAL REGISTRATION: PROSPERO Registration number: CRD420251152380.
Rutnin S, Smitthisakda S, Wittayabusarakam N
… +3 more, Yongpisarn T, Sakpuwadol N, Thadanipon K
J Cosmet Dermatol
· 2026 Apr · PMID 41947502
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BACKGROUND: Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus that causes visible pigmentation and significantly impacts quality of life. Current treatments for LPP are limited, with inconsistent ou...BACKGROUND: Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus that causes visible pigmentation and significantly impacts quality of life. Current treatments for LPP are limited, with inconsistent outcomes from topical, oral, and laser therapies. The 1064-nm picosecond laser has shown potential in managing pigmented skin disorders; however, evidence regarding its effect on LPP remains scarce. OBJECTIVES: This study aimed to evaluate the efficacy, safety, and patient satisfaction of the 1064-nm picosecond laser in treating LPP. METHODS: The study was a randomized, split-face controlled trial. Twelve patients with biopsy-confirmed LPP were enrolled, with one side of each participant treated with four sessions of the 1064-nm picosecond laser at monthly intervals. The Modified Dermal Pigmentation Area and Severity Index (mDPASI) and melanin index (MI), assessed by three-dimensional imaging, were measured before each treatment and at 1, 3, and 6 months following the last treatment. Physician global assessment (PGA) and patient satisfaction scores were assessed at 1 and 6 months following the last treatment. Additionally, adverse events were recorded. RESULTS: A total of 12 patients with LPP, aged 55 ± 11.1 years, were recruited, and 11 completed the study. During the 6 months following the end of laser treatment, no significant differences were found in MI, mDPASI, or PGA between treatment and control groups. However, satisfaction scores showed a significant improvement on the treated side compared to the control. The mean overall pain score was 3.70 ± 1.72, with no major adverse events reported. CONCLUSION: The 1064-nm picosecond laser demonstrated limited effectiveness in improving LPP clinical outcomes. Further studies with sham-controlled trials and larger sample sizes are needed to optimize treatment parameters and sessions, and to validate the role of the picosecond laser as a therapeutic option for LPP.
Maloney ME, Hall M, Kelm RC
… +2 more, Kononov T, Zahr A
J Cosmet Dermatol
· 2026 Apr · PMID 41947480
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BACKGROUND: Ascorbic acid (AA) has protective and corrective functions critical for counteracting extrinsic and intrinsic skin aging and hyperpigmentation, but it is highly unstable, making it challenging to formulate in...BACKGROUND: Ascorbic acid (AA) has protective and corrective functions critical for counteracting extrinsic and intrinsic skin aging and hyperpigmentation, but it is highly unstable, making it challenging to formulate into skincare products. Tetrahexyldecyl (THD) Ascorbate, a lipid-soluble derivative of AA, has superior stability and skin-mimicking properties. AIMS: To investigate the efficacy and tolerability of a novel antioxidant serum containing 30% THD Ascorbate (THD-AA serum), a patent-pending blend of antioxidants and prebiotics, on photoaged and hyperpigmented skin with respect to long-term skin health. METHODS: Using preclinical models and a randomized, double-blind clinical trial, the antioxidant potential, antimelanogenesis, and antiaging properties of the THD-AA serum were evaluated. RESULTS: Using an in vitro tissue model exposed to blue light, there was an 88% reduction in reactive oxygen species (ROS) formation after 30 min, 87% reduction after 60 min, and an 82% reduction after 120 min compared to the blue light-exposed control. Melanin production was reduced by 24% in vitro tissue co-culture. THD-AA serum improved the structural architecture of the skin, including the epidermis, dermal-epidermal junction, and dermis, and upregulated dermal collagen production 4-fold compared to a controlled moisturizer in an ex vivo model. In the clinical trial, existing damage and hyperpigmentation were visibly corrected on VISIA-CR and Antera 3D photographs, as well as in Clinical Grader results. There were no adverse events, and participants tolerated the serum well. CONCLUSIONS: THD-AA serum has clinical and molecular efficacy in buffering ROS, reducing melanogenesis, and promoting antiaging, providing a safe alternative to hydroquinone products.
Olivares M, Araya D, Forero E
… +2 more, Benoit MJ, Mercado V
J Cosmet Dermatol
· 2026 Apr · PMID 41947479
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BACKGROUND: The widespread use of hyaluronic acid (HA) dermal fillers has been accompanied by an increase in vascular complications, including ischemia and cutaneous necrosis. Although uncommon, filler-induced vascular c...BACKGROUND: The widespread use of hyaluronic acid (HA) dermal fillers has been accompanied by an increase in vascular complications, including ischemia and cutaneous necrosis. Although uncommon, filler-induced vascular compromise represents one of the most severe adverse events in aesthetic medicine and requires immediate recognition and intervention. Conventional management strategies based primarily on hyaluronidase may be insufficient in advanced ischemic stages, where inflammatory amplification and microvascular dysfunction contribute to progressive tissue injury. OBJECTIVE: To evaluate the clinical outcomes of the Advanced Regenerative and Immunomodulatory Drainage Protocol (ARDIP), a multimodal therapeutic approach designed to restore tissue perfusion, reduce inflammatory burden, and promote regenerative healing in patients with facial skin necrosis secondary to hyaluronic acid dermal fillers. METHODS: A prospective, non-randomized interventional case series was conducted including 20 patients presenting with vascular occlusion (VO) and cutaneous necrosis following hyaluronic acid injections. Lesions were classified according to a staged ischemic progression system (VO Stages III-Vb). All patients were treated using the ARDIP, which integrates high-dose hyaluronidase reperfusion, topical fibrinolytic therapy, controlled mechanical drainage through micropuncture techniques, and stage-adjusted systemic and regenerative adjuvant therapies. Clinical outcomes were assessed through standardized photographic documentation, healing time, and the Global Aesthetic Improvement Scale (GAIS). RESULTS: All patients completed treatment and follow-up. Complete tissue recovery without visible scarring was achieved in 95% of cases. Mean healing time was 15 ± 2.6 days, with faster recovery in early stages. The mean GAIS score was 1.05 ± 0.22, indicating exceptional aesthetic improvement. No systemic or local adverse events were observed. CONCLUSIONS: ARDIP appears to be a safe and effective multimodal strategy for the management of filler-induced skin necrosis, addressing both mechanical vascular obstruction and the associated inflammatory cascade.
Afzal L, Nguyen N, Afzal N
… +7 more, Adnan S, Khan Z, Dulai AS, Nayak S, Trivedi RR, Min A, Sivamani RK
J Cosmet Dermatol
· 2026 Apr · PMID 41947475
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BACKGROUND: Photoaged skin is primarily induced by prolonged exposure to ultraviolet radiation, leading to increased pigmentation, reduced elasticity, and pronounced wrinkles. There has been an increasing recognition of...BACKGROUND: Photoaged skin is primarily induced by prolonged exposure to ultraviolet radiation, leading to increased pigmentation, reduced elasticity, and pronounced wrinkles. There has been an increasing recognition of the influence of nutrition on skin health, with dietary elements emerging as a viable alternative approach to preventing photoaging. This study explores how oral supplementation impacts photoaged skin, hydration, and elasticity. AIMS: This study evaluates the effects of an antioxidant-rich synbiotic supplement on facial elasticity, hydration, and photoaging markers, such as erythema and pigmentation. PATIENTS/METHODS: In this 8-week study, 36 participants from the Sacramento region were randomized to receive either the antioxidant-rich synbiotic supplement or a placebo. Participants had 3 visits: baseline, week 4, and week 8. Noninvasive facial measurements, including hydration, elasticity, erythema, and pigmentation, were obtained. Facial photography and analysis were performed. Tolerability was assessed. RESULTS: At week 8, the treatment group showed a significant reduction in wrinkle severity (-5.28%, p < 0.01), whereas the placebo group did not. Cheek elasticity increased significantly at week 4 (22.0%, p < 0.01) and week 8 (13.8%, p < 0.05), along with firmness at week 8 (12.2%, p < 0.01). The placebo group showed no significant changes in these parameters. Additionally, the viscoelasticity of the cheek increased at week 4 (30.2%, p < 0.01) in the treatment group, with no change in the placebo group. CONCLUSIONS: The antioxidant-rich synbiotic supplement improved wrinkle severity, skin facial elasticity, and skin firmness, enhancing several parameters of photoaging.
Kang JW, Hur JW, Jang AR
… +2 more, Cho HE, Lee IC
J Cosmet Dermatol
· 2026 Apr · PMID 41947429
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BACKGROUND: Hyperpigmentation, caused by excessive melanin accumulation, is a significant cosmetic concern in dermatology. Natural compounds are receiving attention as safe and effective skin-lightening agents due to the...BACKGROUND: Hyperpigmentation, caused by excessive melanin accumulation, is a significant cosmetic concern in dermatology. Natural compounds are receiving attention as safe and effective skin-lightening agents due to their antioxidant properties and ability to inhibit melanin synthesis. AIMS: To investigate the antioxidant and melanin biosynthesis inhibitory effects of leatherleaf fern water extract (LFWE) and the skin-lightening efficacy of a facial serum containing LFWE through in vitro and clinical trials: MATERIALS AND METHODS: The antioxidant and tyrosinase inhibitory activities of LFWE were confirmed in vitro, along with its inhibitory effects on factors involved in melanin biosynthesis. Its skin-lightening effects were then validated through clinical trials. RESULTS: LFWE demonstrated excellent 1,1-diphenyl-2-picrylhydrazyl and ABTS cation radical scavenging activity and inhibited mushroom tyrosinase activity in a concentration-dependent manner. LFWE also suppressed melanin biosynthesis in B16-F10 melanoma cells without toxicity up to 500 μg/mL and significantly inhibited the protein expression levels of tyrosinase, TRP-1, and TRP-2, which promote melanin production. Clinical trials of a serum containing LFWE showed that it reduced the melanin index after 4 and 8 weeks, thereby confirming its skin-lightening effects. CONCLUSION: LFWE exerts excellent antioxidant effects and inhibits the expression of factors involved in melanin biosynthesis, thereby demonstrating skin-lightening effects. Moreover, LFWE-containing serum significantly reduced melanin indices in clinical trials.
J Cosmet Dermatol
· 2026 Apr · PMID 41947347
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BACKGROUND: Contemporary lip augmentation has evolved from simple volumization techniques to more intricate contour-specific enhancements. Among these advancements, the Modified Cupid's bow lips, characterized by their d...BACKGROUND: Contemporary lip augmentation has evolved from simple volumization techniques to more intricate contour-specific enhancements. Among these advancements, the Modified Cupid's bow lips, characterized by their distinctive Cupid's bow shape and vertical projection, have gained significant popularity as a prominent aesthetic trend. AIMS: This study aims to evaluate the prevalence of patient preference for the Modified Cupid's bow lips contour and to propose a systematic approach for its clinical implementation based on retrospective analysis. METHODS: A retrospective analysis was conducted, including 67 consecutive female patients seeking primary lip augmentation. Demographic information and preferences regarding lip contours were statistically analyzed using chi-square tests with age stratification. Anthropometric measurements of labial tubercle area and upper lip angles were performed using Image Pro Plus software for quantitative assessment. RESULTS: This analysis revealed that 42 patients (62.7%) preferred Modified Cupid's bow lips, a significantly higher proportion compared to the 25 patients (37.3%) who favored natural lips (χ = 4.31, p = 0.038). In addition, a significant correlation was found between age group and lip preference (χ = 8.74, p = 0.033), with the highest preference for Modified Cupid's bow lips (73.9%) that was observed in the 31-40 year age group. Morphometric analysis demonstrated statistically significant post-treatment increases in labial tubercle area (228.5 ± 169.6 mm vs. 297.0 ± 157.3 mm, p = 0.039) and alterations in key angular measurements (Angle γ, δ, ε; p < 0.05), confirming enhanced central projection, vertical height, and contour definition. CONCLUSION: The Modified Cupid's bow lips represent a dominant aesthetic preference and necessitate specialized injection techniques and an understanding of anatomy for optimal results. Objective morphometric changes validate the efficacy of the technique in achieving defined lip contours.
Luo Y, Yu H, Pan L
… +6 more, Yang C, Zhang J, Yu T, Li W, Li X, Xu J
J Cosmet Dermatol
· 2026 Apr · PMID 41937110
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BACKGROUND: Skin aging is a key focus in aesthetic and dermatologic medicine. Transcutaneous electrical acupoint stimulation (TEAS) is a noninvasive, acupuncture-based technique that integrates traditional meridian theor...BACKGROUND: Skin aging is a key focus in aesthetic and dermatologic medicine. Transcutaneous electrical acupoint stimulation (TEAS) is a noninvasive, acupuncture-based technique that integrates traditional meridian theory with modern electrical stimulation. This study evaluated the clinical efficacy and safety of TEAS in improving the clinical signs of facial skin aging and promoting facial rejuvenation. OBJECTIVE: This study aimed to evaluate the effects of TEAS on the clinical signs of facial skin aging. METHODS: Ninety participants were randomly assigned to TEAS, acupuncture, or Sham-TEAS groups. The TEAS group received 30-min treatments, five times per week for four weeks. Primary and secondary outcomes were assessed using the VISIA analysis system and the FACE-Q scale. RESULTS: TEAS significantly reduced wrinkle scores at week 4 and week 8 compared with baseline (p < 0.001) and achieved greater improvement than acupuncture (p < 0.05). FACE-Q scores increased significantly in the TEAS and acupuncture groups compared with Sham-TEAS (p < 0.01), with greater improvement in Social Function in the TEAS group (p < 0.05). Both physician-rated and self-assessed GAIS and WSRS scores also improved in the TEAS group (p < 0.001). CONCLUSION: TEAS appears to be a safe, noninvasive intervention that is primarily effective in reducing wrinkle severity and improving patient-reported outcomes, while showing limited effects on other VISIA parameters of facial skin aging.
Humphrey S, Shimoga S, Kaufman J
… +6 more, Bank D, Biesman B, Harutunian C, West GS, Tong W, Patel V
J Cosmet Dermatol
· 2026 Apr · PMID 41933889
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BACKGROUND: Repetitive contractions of the platysma muscle may result in vertical neck bands that blunt the jawline (i.e., platysma prominence [PP]). We report patient-reported outcomes (PROs) from a phase 2 study evalua...BACKGROUND: Repetitive contractions of the platysma muscle may result in vertical neck bands that blunt the jawline (i.e., platysma prominence [PP]). We report patient-reported outcomes (PROs) from a phase 2 study evaluating onabotulinumtoxinA (onabotA) for moderate or severe PP. METHODS: Subjects were randomized 1:1:1 to onabotA dose 1 (26 U, 31 U, or 36 U), onabotA dose 2 (52 U, 62 U, or 72 U), or placebo. De novo, validated, fit-for-purpose PROs were used to assess treatment satisfaction, bother with vertical neck bands and jawline, jawline definition, and psychosocial impact. RESULTS: Subjects with PRO data (N = 164; mean age, 50.0 years) were predominantly female (95.1%) and White (93.9%). Response rates for improvement in both onabotA dose groups were higher than placebo for treatment satisfaction, bother with vertical neck bands and jawline, as well as jawline definition (unadjusted p < 0.05 for all). Greater improvements in treatment satisfaction and psychosocial impact were observed in both dose groups versus placebo based on the mean total scores on the Appearance of Neck and Lower Face Questionnaire (ANLFQ): Satisfaction and the mean change from baseline in ANLFQ: Impacts total score, respectively (unadjusted p < 0.0001 for all). Response rates generally peaked across all measures at day 14 or 30 for both dose groups, with a trend in improvement continuing through day 120. CONCLUSIONS: Compared with placebo, both onabotA dose groups reported greater satisfaction with the effect of treatment, improvements in jawline definition and psychological impact, as well as reductions in bother due to vertical neck bands and jawline. TRIAL REGISTRATION: ClinicalTrials.gov: NCT03915067.
Callender V, Burgess C, Harvey VM
… +5 more, Heath C, Mitchell H, Woolery-Lloyd H, Andriessen A, McMichael A
J Cosmet Dermatol
· 2026 Apr · PMID 41928381
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BACKGROUND: Hair type classification is crucial for developing personalized hair care, maximizing hair health, and selecting appropriate treatment for scalp disorders, yet it remains underutilized in clinical practice. A...BACKGROUND: Hair type classification is crucial for developing personalized hair care, maximizing hair health, and selecting appropriate treatment for scalp disorders, yet it remains underutilized in clinical practice. AIMS: This review aimed to address three main questions: (1) How can hair types be defined according to specific shape criteria, without referring to race/ethnicity? (2) Why does certain hair exhibit a curly pattern, and how does curly hair behave uniquely? (3) How is the classification of curly hair clinically relevant to the development of seborrheic dermatitis? METHODS: PubMed and Google Scholar were the primary and secondary platforms used for the literature search, respectively. The scope of the search included English-language human studies published between 2000 and 2025 that investigated classification systems defining hair types based on specific shape criteria. RESULTS: The literature review revealed four mainstream hair classification systems: the André Walker Hair Typing System, the LOIS Hair Typing System, the FIA Hair Typing System, and the L'Oréal Curl Classification System. There are shared characteristics across the systems, as each was built on previous ones to incorporate nuances of different hair types and curl patterns. The L'Oréal Curl Classification System acknowledges the broader continuum of hair types by categorizing straight, wavy, curly, and coiled hair using four morphological parameters. CONCLUSIONS: There are several existing hair classification systems that dermatologists and other health care professionals can use to optimize communication with patients. Dermatologists' use of these classification systems and increased awareness of practices for high-curl-pattern hair could ultimately improve treatment outcomes. Curl pattern classification may also have predictive value in the treatment of scalp diseases (e.g., seborrheic dermatitis), but further validation is required.