Clinical, Cosmetic And Investigational Dermatology[JOURNAL]
Sun
200 papers
Network Pharmacology and Animal Experimental Validation on the Therapeutic Mechanisms of Extract in Psoriasis.
Wang H, Ding Y, Wang Z … +4 more , Wang Y, Liu Y, Ma Y, Wu W
Clin Cosmet Investig Dermatol · 2026 · PMID 42388899 · Full text
BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by excessive keratinocyte proliferation and persistent inflammation. Its multifactorial pathogenesis involves complex inflammato...
BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by excessive keratinocyte proliferation and persistent inflammation. Its multifactorial pathogenesis involves complex inflammatory mediators and signaling pathways. Current treatments remain limited by high recurrence and adverse effects, highlighting the need for safe and effective natural bioactive compounds for psoriasis prevention and management. In addition, cyclin B1 (CCNB1) has been reported as a hub gene associated with psoriasis; however, its mechanism of action remains unclear. OBJECTIVE: To elucidate the potential therapeutic mechanisms of a bioactive extract derived from fruit powder (PCE10) by integrating network pharmacology and animal experimental validation. METHODS: A psoriasis-like mouse model was established using imiquimod (IMQ) in mice as the study subjects. The anti-psoriatic effect of PCE10 was assessed using the Psoriasis Area and Severity Index (PASI), histopathological examination, and inflammatory cytokine assays. Network pharmacology combined with machine learning algorithms was employed to identify psoriasis-associated target genes potentially regulated by PCE10. Molecular docking were subsequently performed to predict the binding interactions between candidate bioactive compounds and key molecular targets. RESULTS: Network pharmacology identified 67 psoriasis-related targets, with 23 hub genes detected in the protein-protein interaction network. Enrichment analyses indicated involvement in inflammatory regulation and TNF, NF-κB, and p53 pathways. Machine learning identified CCNB1 as a key psoriasis-associated gene. Molecular docking indicated interactions between p53 and the bioactive compounds of PCE10. In vivo, PCE10 alleviated IMQ-induced psoriasis-like dermatitis and reduced epidermal hyperplasia, decreasing serum levels of IL-23, IL-17A, and TNF-α. Mechanistically, PCE10 suppressed keratinocyte proliferation by modulating the p53/CCNB1 axis. CONCLUSION: PCE10 may exert anti-psoriatic effects through modulation of p53/CCNB1 regulatory axis. Nevertheless, this study is mainly based on an IMQ-induced mouse model and is not supported by validation in human psoriatic skin tissues or clinical specimens. Additional translational studies are required to establish its clinical applicability.
Evaluation of Parameters Determining the Pull-Out Strength of Poly(L-Lactide-Co-ε-Caprolactone) Barbed Suspension Threads: A Comparative ex vivo Study.
Fundaro S, Malgapo DMH, Manni M
Clin Cosmet Investig Dermatol · 2026 · PMID 42388898 · Full text
PURPOSE: This study aimed to examine a pull-out strength test methodology and compare the pull-out strength of different insertion methods for poly(L-lactide-co-ε-caprolactone) (PLCL) barbed suspension threads. METHODS:...
PURPOSE: This study aimed to examine a pull-out strength test methodology and compare the pull-out strength of different insertion methods for poly(L-lactide-co-ε-caprolactone) (PLCL) barbed suspension threads. METHODS: A custom-designed "pull-out strength test device" was used to measure the maximum force required to pull out threads inserted into an ex vivo turkey breast model. RESULTS: Insertion techniques influence pull-out strength. Additionally, trend analysis indicated that thinner needles (0.85 mm) generally yielded higher pull-out resistance than larger diameter needles (1.28 mm), suggesting they may create a tighter initial grip within the tissue. CONCLUSION: Different insertion techniques influence the pull-out strength of PLCL in an ex vivo model.
Optimizing Abrocitinib Use for Atopic Dermatitis in India: Expert Recommendations for Patient Selection, Dosing, and Long‑Term Remission.
Kandhari S, De A, Shankar K … +7 more , G R, Pereira R, Jagadeesan S, Panda M, Singh V, Chakravadhanula U, Banodkar P
Clin Cosmet Investig Dermatol · 2026 · PMID 42382839 · Full text
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder which significantly impairs quality of life due to persistent pruritus, sleep disturbance, and recurrent flares. Conventional systemic therapies,...
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder which significantly impairs quality of life due to persistent pruritus, sleep disturbance, and recurrent flares. Conventional systemic therapies, such as cyclosporine and methotrexate, often provide inadequate itch and disease control, with limited safety and poor long-term tolerability. The introduction of targeted small-molecule therapies, particularly Janus kinase (JAK) inhibitors, has substantially transformed AD management by enabling rapid itch relief and sustained clinical improvements. Abrocitinib, an oral selective JAK1 inhibitor, has demonstrated rapid and clinically meaningful reduction in pruritus, improvement in skin lesions, and a favorable benefit-risk profile in pivotal clinical trials. However, guidance regarding its optimal real-world use in Indian patients remains limited. This expert recommendation aims to provide practical, experience-based recommendations for the initiation, dosing, monitoring, and long-term management of abrocitinib in patients with moderate-to-severe AD in India. A multistep approach was employed, including a targeted literature review conducted between September and November 2025, a nationwide survey of 36 experienced dermatologists, and two virtual expert panel meetings involving 10 senior clinicians. Experts have identified abrocitinib as a valuable systemic option, particularly for patients with pruritus‑dominant disease, head and neck involvement, hand eczema, elderly patients with comorbidities, and those inadequately controlled with biologics or other systemic agents. Baseline assessment of hematologic, hepatic, renal, lipid, infectious, cardiovascular, and thrombotic risks was emphasized, with follow-up monitoring recommended at four weeks and following dose modifications. An induction dose of 200 mg once daily was preferred for most patients, with 100 mg reserved for the selected populations. Strategies for maintenance, dose tapering, and treatment transitions were also discussed. Overall, these expert recommendations provide practical real-world guidance supporting the individualized, safe, and effective use of abrocitinib in the Indian clinical setting, while emphasizing the importance of structured monitoring and long-term treatment planning.
Evolving Research Hotspots and Emerging Trends in Atopic Dermatitis and Inflammatory Bowel Disease: A Bibliometric Analysis.
Li Z, Deng C, Lu B … +4 more , Chen F, Cao X, Fan J, Song Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42382838 · Full text
BACKGROUND: The number of people affected by atopic dermatitis (AD) and inflammatory bowel disease (IBD) continues to rise, increasing the disease burden. These conditions are epidemiologically linked and share features...
BACKGROUND: The number of people affected by atopic dermatitis (AD) and inflammatory bowel disease (IBD) continues to rise, increasing the disease burden. These conditions are epidemiologically linked and share features related to barrier dysfunction, immune dysregulation, and microbial dysbiosis, making them an important focus of integrated research. However, systematic bibliometric analysis of this field remains lacking. This study aimed to characterize the publication landscape, knowledge structure, evolving hotspots, and emerging translational trends in AD-IBD research. METHODS: English-language articles and reviews on the intersection of AD and IBD published between 2000 and 2025 were retrieved from the Web of Science Core Collection and Scopus. After merging, deduplication, and data standardization, CiteSpace, VOSviewer, and Scimago Graphica were used to analyze publication trends, country/region and institutional contributions, author and journal profiles, keyword co-occurrence, and co-cited references. RESULTS: A total of 1,542 publications were included. Annual publication output increased steadily, with a marked acceleration after 2020. The United States ranked first in publication volume, total citations, and international collaboration strength, while Harvard University occupied a central position in the institutional collaboration network. The Journal of Allergy and Clinical Immunology ranked first in both citation and co-citation counts. Keyword clustering and co-cited reference burst analyses identified four major directions: gut microecology and immune regulation, shared inflammatory pathways and immune-mediated comorbidities, therapeutic strategies involving biologics and JAK inhibitors, and genetic susceptibility and causal inference. The field has gradually shifted from epidemiological associations and inflammatory mechanism exploration toward clinical translation and safety evaluation. CONCLUSION: AD-IBD research has evolved into a multidisciplinary field centered mainly in North America and Europe, with rapidly expanding contributions from Asia. Future studies should strengthen interdisciplinary and cross-regional collaboration and prioritize gut-skin axis mechanisms, stratified management of comorbid populations, and long-term risk-benefit assessment of targeted therapies.
A Preliminary Study of Polycaprolactone Filler After Hyaluronidase for Facial Overfilled Syndrome.
Xue Z, Kim C, Hwang D
Clin Cosmet Investig Dermatol · 2026 · PMID 42371529 · Full text
BACKGROUND: Hyaluronidase effectively degrades hyaluronic acid (HA) fillers in facial overfilled syndrome (FOS). However, the subsequent volume reduction may create soft tissue hollowing and contour irregularities. OBJEC...
BACKGROUND: Hyaluronidase effectively degrades hyaluronic acid (HA) fillers in facial overfilled syndrome (FOS). However, the subsequent volume reduction may create soft tissue hollowing and contour irregularities. OBJECTIVE: To evaluate the aesthetic and structural changes following polycaprolactone (PCL) filler injection after hyaluronidase treatment in patients with FOS. METHODS: This single-arm, retrospective study enrolled patients with FOS who underwent hyaluronidase treatment followed by a PCL injection. Outcomes included Global Aesthetic Improvement Scale (GAIS), upper cheek fullness, temporal hollowing, 3D midfacial volume, and ultrasound-measured soft tissue-to-bone distance. Assessments were performed at baseline, after hyaluronidase, and at 3 and 6 months post-PCL treatment. RESULTS: 12 patients were enrolled. At 6 months after PCL injection, improvements were observed in GAIS (P < 0.001) and upper cheek fullness (P = 0.016). Using the pre-hyaluronidase state as baseline, the 3D midfacial filler volume decreased by 2.48 mL after hyaluronidase injection (P < 0.001), by 4.88 mL at 3 months after PCL treatment (P < 0.001), and by 5.14 mL at 6 months after PCL treatment (P < 0.001). Conversely, the ultrasound-assessed distance from soft tissue to bone surface was 1.21 mm greater than baseline after hyaluronidase treatment (P < 0.001), and 2.09 mm and 3.23 mm lower than baseline at 3 and 6 months after PCL injection, respectively (both P < 0.001). No adverse events were reported after hyaluronidase and PCL treatment. CONCLUSION: In this preliminary study, aesthetic improvement and changes in soft tissue parameters were observed after PCL injection following hyaluronidase treatment.
Successful Treatment of Extensive Ritlecitinib-Refractory Alopecia Areata with Upadacitinib.
Sun W, Wang H, Liu Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42368720 · Full text
Alopecia areata is a non-scarring form of hair loss with an undetermined etiology that can profoundly affect patients both cosmetically and psychologically. As immune cells are implicated in the pathogenesis, molecularly...
Alopecia areata is a non-scarring form of hair loss with an undetermined etiology that can profoundly affect patients both cosmetically and psychologically. As immune cells are implicated in the pathogenesis, molecularly targeted drugs can be used for therapy. This report presents a case of a patient who suffered from alopecia areata for two years. Our patient failed to respond to standard therapy using traditional Chinese medicine techniques. This necessitated a shift to a different drug with improved efficacy and outcomes. Initial treatment revealed that the patient had ritlecitinib-resistant alopecia areata, which showed significant signs of recovery following treatment with upadacitinib. By the 24-week follow-up, all symptoms of alopecia had sufficiently normalized. This report also highlights the advantages of upadacitinib and the role of JAK1-mediated pathways in certain patients with alopecia. Thus, It suggests that adoption of personalized treatment strategies might have an effect for patients with alopecia areata.
Clinical Characteristics, Dermoscopic Features and Prognosis of Acquired Facial Pigmented Macules in Young Children: A Retrospective Analysis of 160 Cases.
Sun C, Zhang H
Clin Cosmet Investig Dermatol · 2026 · PMID 42358346 · Full text
OBJECTIVE: To investigate the clinical manifestations, dermoscopic features, and long-term prognosis of acquired facial pigmented macules in young children, and to provide evidence for clinical diagnosis and management....
OBJECTIVE: To investigate the clinical manifestations, dermoscopic features, and long-term prognosis of acquired facial pigmented macules in young children, and to provide evidence for clinical diagnosis and management. PATIENTS AND METHODS: A retrospective study was conducted on 160 children diagnosed with acquired facial pigmented macules at the Dermatology Outpatient Clinic of the Children's Hospital of Nanjing Medical University between January 2017 and September 2025. Clinical data, including sex, age of onset, lesion distribution, color, morphology, and dermoscopic features, were analyzed. Follow-up was performed during outpatient visits or during WeChat to assess lesion regression and prognosis. RESULTS: The male-to-female ratio was 1.46:1, with a mean onset age of (0.66 ± 0.35) years, mostly within 6-8 months after birth. Lesions were irregular brown or brownish-red macules (4mm-3cm, mainly 4mm-1cm), predominantly located on the forehead and temporal regions. Two dermoscopic patterns were identified: a non-infiltrating pattern (pseudogrid-like brown pigmentation with linear or punctate telangiectasia), and an infiltrating pattern (pseudogrid-like brown pigmentation without vascular changes). Among 110 followed-up children, 93.64% achieved complete lesion regression at a mean age of (2.82 ± 0.69) years, mostly within 4 years old. CONCLUSION: Acquired facial pigmented macules in young children are benign, self-limiting disorders with characteristic clinical and dermoscopic findings. Spontaneous regression occurs in most cases and no specific treatment is required.
Emerging Surgical Therapies for Vitiligo: Tissue vs Cell-Based Approaches.
Ren C, Dong L, Zhang J
Clin Cosmet Investig Dermatol · 2026 · PMID 42358345 · Full text
Vitiligo is a common dermatologic condition characterized by skin depigmentation. The current spectrum of treatments includes topical and systemic therapies, phototherapy, and surgical options. Recent years have witnesse...
Vitiligo is a common dermatologic condition characterized by skin depigmentation. The current spectrum of treatments includes topical and systemic therapies, phototherapy, and surgical options. Recent years have witnessed notable advancements in surgical techniques, which are broadly categorized into tissue grafting and cell transplantation. Tissue grafting methods include follicular unit grafting, suction blister epidermal grafting, and thin split-thickness skin grafts. Cell transplantation techniques involve the use of autologous cultured melanocytes, non-cultured epidermal cell suspensions, and non-cultured cell suspensions from hair follicle outer root sheaths. To enhance surgical efficacy, future studies should aim to uncover the therapeutic mechanisms and identify relevant biomarkers.
Mapping the Fine-Scale Aging Landscape of Young Chinese Women: A LOESS-Based Analysis of 45 Biophysical Skin Parameters.
Fan Y, Hu J, Shan S
Clin Cosmet Investig Dermatol · 2026 · PMID 42344746 · Full text
BACKGROUND: Facial skin aging is a complex, progressive process, but subtle and nonlinear changes during young adulthood remain insufficiently characterized. This study aimed to develop an early-aging atlas of facial ski...
BACKGROUND: Facial skin aging is a complex, progressive process, but subtle and nonlinear changes during young adulthood remain insufficiently characterized. This study aimed to develop an early-aging atlas of facial skin in young Chinese women and to identify key age-related turning points among the various aging traits. METHODS: A total of 500 Chinese female volunteers aged 18-33 years participated in this study. We assessed 45 physiological skin parameters associated with barrier function, color, texture, pigmentation, and wrinkles using various noninvasive skin assessment techniques. Beyond Pearson correlation analysis, we used locally weighted scatterplot smoothing (LOESS) to model how these skin parameters evolve with age, capturing any nonlinear patterns. RESULTS: Age-related facial changes were detectable even within this young cohort. Sebum secretion and skin elasticity declined with age, whereas pigmentation, roughness, and wrinkle-related parameters increased. LOESS analysis suggested several approximate age-related transition points. Around 22 years of age, skin dullness and latent UV damage appeared to increase. Around 25 years, periocular wrinkles and mid-face roughness became more evident. After 27 years, brown spots showed a more apparent upward trend. Around 29-30 years, skin elasticity showed a more marked decline, accompanied by a secondary decrease in sebum secretion. These LOESS-indicated transition periods should be interpreted as exploratory rather than mathematically confirmed thresholds. CONCLUSION: Early facial aging in young Chinese women follows asynchronous and nonlinear trajectories across different skin dimensions. The identified transition points before age 30 provide a quantitative basis for understanding the temporal progression of early facial aging and may support age-specific prevention and intervention strategies.
Townes-Brocks Syndrome as Familial Isolated Bilateral Cup Ear Deformity: A Case Report.
Chang Y, Yang L, Zhang Z … +2 more , Zhang H, Xue F
Clin Cosmet Investig Dermatol · 2026 · PMID 42338547 · Full text
Townes-Brocks syndrome (TBS) is a rare autosomal dominant disorder caused by pathogenic variants in SALL1. Although classically characterized by external ear anomalies, anorectal malformations, and thumb/radial defects,...
Townes-Brocks syndrome (TBS) is a rare autosomal dominant disorder caused by pathogenic variants in SALL1. Although classically characterized by external ear anomalies, anorectal malformations, and thumb/radial defects, its expressivity is highly variable and mild presentations may be overlooked. We report a 7-year-old boy presenting for cosmetic correction of bilateral cup ear deformities. Initial hearing screening and renal ultrasonography showed no abnormalities, and no other anomalies were identified on clinical examination. Detailed history-taking and construction of a three-generation pedigree revealed that the patient's father and paternal grandfather had similar bilateral auricular deformities, suggesting autosomal dominant familial transmission. Genetic testing of the proband and father demonstrated a heterozygous frameshift variant in exon 2 of SALL1 (c.1949del; p.Gly650AlafsTer46). The proband and his father underwent corrective otoplasty and achieved satisfactory early cosmetic outcomes. This family illustrates that SALL1-related TBS can present as an apparently isolated auricular phenotype. Familial congenital cup ear deformity, even when encountered in a cosmetic setting, should prompt careful family history-taking, consideration of genetic evaluation, counseling, and longitudinal surveillance.
A Successful Outcome of Upadacitinib Therapy in a Patient with Genital Erosive Fixed Drug Eruption: A Case Report.
Li C, Wang X, Li X … +5 more , Xu M, Kong S, Tao X, Liu W, Wan H
Clin Cosmet Investig Dermatol · 2026 · PMID 42338546 · Full text
Fixed drug eruption (FDE) is a common cutaneous adverse drug reaction with limited effective treatments for severe genital erosive cases. This first reported case demonstrates the successful use of the selective Janus ki...
Fixed drug eruption (FDE) is a common cutaneous adverse drug reaction with limited effective treatments for severe genital erosive cases. This first reported case demonstrates the successful use of the selective Janus kinase 1 (JAK1) inhibitor upadacitinib as monotherapy for a severe, erosive FDE involving the genitalia. A 50-year-old male presented with rapidly progressing, painful erythema, erosions, and exudation on the scrotum and glans penis following drug intake, confirmed by histopathology. Treated solely with upadacitinib, the lesions achieved near-complete re-epithelialization by day 18, with no recurrence or adverse events during follow-up. This case highlights upadacitinib as a rapidly effective and well-tolerated novel therapeutic option for severe FDE in sensitive areas, addressing an unmet need and expanding the potential application of targeted Janus kinase (JAK) inhibition in cutaneous adverse drug reactions.
Ultrasound Features and Clinical Pathological Characteristics of Acquired Periungual Fibrokeratoma: Two Case Reports.
He D, Tao H, Xia H … +1 more , Liu Z
Clin Cosmet Investig Dermatol · 2026 · PMID 42338545 · Full text
BACKGROUND: Acquired periungual fibrokeratoma (APF) is a rare benign neoplasm that can cause longitudinal nail plate malformation. Although the significance of high-frequency ultrasound (HFUS) in the assessment of nail u...
BACKGROUND: Acquired periungual fibrokeratoma (APF) is a rare benign neoplasm that can cause longitudinal nail plate malformation. Although the significance of high-frequency ultrasound (HFUS) in the assessment of nail unit lesions has been well - established, its sonographic characteristics remain insufficiently documented. To describe the sonographic characteristics of acquired periungual fibrokeratoma in two cases, offering early observations to inform future studies. METHODS: Two patients with histopathologically confirmed acquired periungual fibrokeratoma were examined using high-frequency ultrasound (HFUS), and the sonographic features were correlated with clinical and histopathological findings. RESULTS: High-frequency ultrasound (HFUS) accurately delineated the size, location, and morphology of acquired periungual fibrokeratoma as well-defined, hypoechoic, nail matrix-based nodules with minimal internal vascularity. Sonographic measurements closely matched gross specimens, demonstrating strong imaging-surgical correlation and supporting the utility of ultrasound in preoperative evaluation. CONCLUSION: High-frequency ultrasound (HFUS) revealed that the acquired periungual fibrokeratoma presented as a well-demarcated, hypoechoic nodule originating from the nail matrix, with minimal internal vascularity,correlating closely with histopathology. These findings add to the limited imaging literature, aid differentiation from other periungual tumors, and support preoperative mapping to protect the nail matrix. Routine use of HFUS is advocated to improve surgical outcomes and preserve nail apparatus function.
Current Perspectives on Photodynamic Therapy for Skin Diseases: A Narrative Review.
Beutler K, Nowicka D, Chilicka-Hebel K
Clin Cosmet Investig Dermatol · 2026 · PMID 42333210 · Full text
Photodynamic therapy (PDT) is a minimally invasive treatment widely used in dermatology for various skin diseases. It works through the interaction of a photosensitizer, light, and oxygen, producing reactive oxygen speci...
Photodynamic therapy (PDT) is a minimally invasive treatment widely used in dermatology for various skin diseases. It works through the interaction of a photosensitizer, light, and oxygen, producing reactive oxygen species that selectively destroy abnormal cells. PDT is well established in treating conditions such as actinic keratosis, Bowen's disease, and superficial basal cell carcinoma, with good cosmetic outcomes. Increasing evidence also supports its use in non-cancerous conditions, including acne, photoaging, and certain infections. Despite its advantages, limitations such as treatment-related pain and reduced effectiveness in thicker lesions remain challenges. Ongoing research aims to improve photosensitizers, delivery methods, and light technologies to enhance its clinical effectiveness.
Q-Switched 1064 nm Fractional Laser with Intradermal Tranexamic Acid for Melasma: A Retrospective Propensity Score-Matched Study.
Zhang R, Zhang Q, Jing H … +1 more , Song P
Clin Cosmet Investig Dermatol · 2026 · PMID 42333209 · Full text
PURPOSE: To evaluate the efficacy and safety of Q-switched 1064 nm fractional laser combined with intradermal tranexamic acid (TXA) injection in the treatment of melasma. PATIENTS AND METHODS: This retrospective study in...
PURPOSE: To evaluate the efficacy and safety of Q-switched 1064 nm fractional laser combined with intradermal tranexamic acid (TXA) injection in the treatment of melasma. PATIENTS AND METHODS: This retrospective study initially reviewed 161 female patients with melasma who received laser therapy alone (group A), intradermal TXA injection alone (group B), and combination therapy (group C). After eligibility screening and 1:1:1 propensity score matching, 90 patients were included in the final matched analysis, with 30 patients in each group. Clinical outcomes were assessed using the Melasma Area and Severity Index (MASI), VISIA-derived ultraviolet and brown spot indices, and patient satisfaction. Adverse events and recurrence at 6 months were also evaluated. RESULTS: All groups demonstrated significant improvements in MASI scores and VISIA parameters (all P < 0.001). The combination group achieved significantly greater reductions in MASI scores and pigmentation indices compared with the other groups (all P < 0.001), along with a higher likelihood of patient satisfaction (OR = 3.82, 95% CI: 1.15-12.69, P = 0.028). Recurrence rates at 6 months were not significantly different among groups (P = 0.31), although numerically lower in the combination group. All treatments were well tolerated, with only mild and transient adverse events. CONCLUSION: Q-switched 1064 nm fractional laser combined with intradermal TXA injection was associated with greater clinical improvement and higher patient satisfaction compared with monotherapies.
Aesthetic Use of Poly-L-Lactic Acid and Hyaluronic Acid Fillers in Medication-Driven Weight Loss Due to GLP-1 Receptor Agonists: Real-World Case Series from Latin America.
Avelar LET, Sarlos P, Guarnieri C … +8 more , Alvarez PP, Rojas GA, Rossiere N, Toro VA, Kamamoto C, Gomes RT, Nogueira A, Miot HA
Clin Cosmet Investig Dermatol · 2026 · PMID 42328491 · Full text
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prescribed for diabetes and obesity management. The medication-driven weight loss (mdWL) induced by GLP-1RAs may lead to facial hollowing,...
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prescribed for diabetes and obesity management. The medication-driven weight loss (mdWL) induced by GLP-1RAs may lead to facial hollowing, laxity, and wrinkle accentuation. Minimally invasive strategies are needed to restore facial harmony in this population. PURPOSE: To evaluate the effectiveness of poly-L-lactic acid (PLLA-SCA) and hyaluronic acid fillers for facial rejuvenation in women undergoing GLP-1RA-induced mdWL. PATIENTS AND METHODS: This retrospective, multicenter, real-world case series included 15 women (aged 30-50 years) from four Latin American countries who used GLP-1RAs for mdWL and were treated with PLLA-SCA and hyaluronic acid filler injections. Outcomes were assessed through clinical photos at baseline and around 85-100 days (D90) using the Facial Laxity Rating Scale (FLRS), Wrinkle Severity Rating Scale (WSRS), Global Aesthetic Improvement Scale (GAIS; participant and investigator assessments), and a satisfaction questionnaire. Safety events were recorded. RESULTS: Participants achieved 17.9% weight reduction from baseline. At D90, FLRS scores decreased from 4.5 (SD 2.2) to 2.6 (SD 1.8; p<0.001), and WSRS scores from 3.1 (SD 1.5) to 1.9 (SD 1.0; p=0.003). Eight patients (53%) reduced FLRS by ≥2 points, and 11 of 13 patients (85%) with baseline WSRS >1 showed improvement. All participants reported aesthetic improvement (pGAIS), with 40% rating "exceptional improvement". Investigator GAIS confirmed improvement in 100% of cases. At D90, 87% were satisfied or very satisfied. No serious adverse events occurred; transient ecchymoses and edema resolved spontaneously within 72 hours. CONCLUSION: The combined use of PLLA-SCA and hyaluronic acid fillers is an effective strategy to correct facial skin laxity, volume loss, and smooth nasolabial fold and wrinkles following GLP-1RA-induced mdWL with a satisfactory safety profile. These findings suggest that a combined injectable approach may be beneficial to address the aesthetic impact of mdWL in real-world clinical practice among Latin Americans.
Operational Standard for Tissue-Extracted Collagen Facial Injection Techniques.
Ao Y, Wang X, Shi B
Clin Cosmet Investig Dermatol · 2026 · PMID 42328490 · Full text
BACKGROUND: Since its first approval in 1981, tissue-extracted collagen injection technology has become an important method for minimally invasive facial rejuvenation, with substantial clinical experience accumulated par...
BACKGROUND: Since its first approval in 1981, tissue-extracted collagen injection technology has become an important method for minimally invasive facial rejuvenation, with substantial clinical experience accumulated particularly in the periorbital area. However, due to significant differences in physicochemical properties and metabolic mechanisms compared to hyaluronic acid, its clinical application still faces limitations in understanding and unique complication risks. Furthermore, no unified technical operating standards currently exist internationally. METHODS: This standard is based on a synthesis of multicenter expert clinical experience. It systematically outlines the product characteristics, classification, and specifications of tissue-extracted collagen; defines clinical indications, contraindications, and operational precautions; specifies qualification requirements for medical institutions and operating physicians; establishes protocols for pre-operative assessment, regional injection design, post-operative management, and complication prevention and treatment strategies; and proposes multimodal treatment recommendations combining surgery, thread lifting, energy-based devices, and other fillers. CLINICAL RECOMMENDATIONS: Through standardized operating procedures and layered injection techniques, the safety and efficacy of tissue-extracted collagen injection therapy can be effectively improved, reducing the occurrence of complications such as nodules and vascular embolism. Combined treatment strategies further expand the application of collagen in facial rejuvenation, achieving complementary effects and optimizing recovery periods. CONCLUSION: This operational standard provides systematic and standardized clinical guidance for tissue-extracted collagen facial injection. It contributes to promoting the appropriate application and healthy development of this technology, enhancing overall treatment quality and patient satisfaction.
Exosomes in Psoriasis: From Pathogenic Mechanisms to Therapeutic Innovations.
Xu Q, Liu W, Zhang S … +1 more , Zhou L
Clin Cosmet Investig Dermatol · 2026 · PMID 42328489 · Full text
Psoriasis is a chronic recurrent inflammatory disease driven by keratinocytes and immune cells. Exosomes, as key mediators of intercellular communication, play multidimensional roles in this disease. In terms of pathogen...
Psoriasis is a chronic recurrent inflammatory disease driven by keratinocytes and immune cells. Exosomes, as key mediators of intercellular communication, play multidimensional roles in this disease. In terms of pathogenic mechanisms, exosomes released from psoriatic lesions carry non‑coding RNAs and proteins that program T‑cell polarization, drive M1 macrophage activation, and amplify keratinocyte inflammation, thereby sustaining the IL‑23/Th17 immune axis. Translational breakthroughs have repurposed these same vesicles into diagnostic and therapeutic tools. Circulating exosomal fingerprints offer non‑invasive biomarkers for disease activity and psoriatic arthritis differentiation. Leveraging their biocompatibility and low immunogenicity, exosomes from mesenchymal stem cells, plants, and microbes serve as cell‑free platforms achieving immune regulation, antioxidant effects, and microecological repair. Engineering strategies-including cargo loading, membrane surface modification and intelligent microneedle delivery systems-further enhance targeting and efficacy. Despite these advances, clinical translation faces fundamental challenges: lack of production standardization, undefined core active components and insufficient high‑level clinical evidence. Future efforts should prioritize international standards, rational design, and rigorous trials to accelerate exosome‑based precision medicine for psoriasis.
Exploring the Role of Skin Microbiota in Autoimmune Skin Diseases from a Bidirectional Mendelian Randomization Perspective.
Wang J, Wang X, Tao X … +4 more , Yang Q, Zhang M, Wang Y, Liu S
Clin Cosmet Investig Dermatol · 2026 · PMID 42328488 · Full text
BACKGROUND: The etiologies of psoriasis, localized scleroderma (LoS), and systemic lupus erythematosus (SLE) remain incompletely understood. Although skin microbiota are implicated in cutaneous immune homeostasis, their...
BACKGROUND: The etiologies of psoriasis, localized scleroderma (LoS), and systemic lupus erythematosus (SLE) remain incompletely understood. Although skin microbiota are implicated in cutaneous immune homeostasis, their causal relationships with autoimmune skin diseases are unclear. OBJECTIVE: To investigate bidirectional causal associations between skin microbiota and psoriasis, LoS, and SLE. METHODS: Summary-level genome-wide association study (GWAS) data for 1656 skin microbiome traits were obtained from public resources, and GWAS data for psoriasis, LoS, and SLE were obtained from FinnGen version 9. Two-sample Mendelian randomization (MR) was performed using inverse-variance weighting as the primary method, supplemented by MR-Egger regression, weighted median, simple mode, weighted mode, heterogeneity tests, pleiotropy assessment, MR-PRESSO, and leave-one-out analysis. RESULTS: Forward MR identified skin microbiota traits associated with the risk of psoriasis, LoS, and SLE. Specifically, 4, 5, and 5 microbiota traits were positively associated with these diseases, respectively, whereas 4, 3, and 8 traits were inversely associated. Reverse MR suggested that psoriasis, LoS, and SLE may also influence skin microbiota composition: psoriasis and LoS were associated with increased abundance of 4 and 1 microbiota traits, respectively, and psoriasis, LoS, and SLE were associated with reduced abundance of 8, 6, and 2 traits, respectively. Most significant associations showed no strong evidence of heterogeneity or horizontal pleiotropy. CONCLUSION: This bidirectional MR study provides genetic evidence supporting reciprocal relationships between skin microbiota and autoimmune skin diseases. The findings are exploratory and require replication in larger multi-ancestry cohorts and functional validation before clinical translation.
Integrated Transcriptomic and Single-Cell Analyses Link ATP7A, a Cuproptosis-Related Hub Gene, to ECM-Adhesion Signaling Dysfunction in UVB-Induced Skin Photodamage.
Li S, Wan W, Meng T … +3 more , Zhang J, Xiao Y, Cao X
Clin Cosmet Investig Dermatol · 2026 · PMID 42328487 · Full text
OBJECTIVE: To investigate the link between UVB-induced skin photodamage and cuproptosis, and identify key regulatory genes. METHODS: Transcriptomic data from UVB-irradiated human skin (GSE41078) were obtained from GEO. D...
OBJECTIVE: To investigate the link between UVB-induced skin photodamage and cuproptosis, and identify key regulatory genes. METHODS: Transcriptomic data from UVB-irradiated human skin (GSE41078) were obtained from GEO. Differentially expressed genes (DEGs) were identified, followed by GO and KEGG enrichment, and WGCNA. Key regulators were defined by intersecting DEGs, cuproptosis-related genes (CRGs), and the WGCNA module most correlated with photodamage. Single-cell RNA-seq data (GSE289389) were used to assess ATP7A expression in keratinocytes and to infer cell-cell communication (CellChat), focusing on ECM and adhesion signaling. Hub genes were validated via qRT-PCR and Western blot in UVB-induced acute photodamage cells and mouse models. RESULTS: Examination of the GSE41078 dataset revealed 509 DEGs associated with photodamage. WGCNA identified the blue module as most strongly correlated with photodamage. Cross-referencing 978 core module genes with 55 CRGs and 509 DEGs identified a single hub gene, ATPase copper transporting alpha (ATP7A). Single-cell analysis confirmed significant ATP7A downregulation after UVB exposure (p = 1.83 × 10) and showed that ATP7A-high keratinocytes exhibited stronger integration with stromal cells via enhanced ECM-adhesion signaling (e.g. collagen, laminin), whereas ATP7A-low cells displayed weakened responsiveness to microenvironmental cues. Experimental confirmation suggested that both mRNA and protein expression of ATP7A were markedly diminished in photodamaged cellular and mouse models (P < 0.05), aligning with the computational predictions. CONCLUSION: This study suggests a potential association between ATP7A downregulation and UVB-induced photodamage with possible relevance to cuproptosis-related pathways. ATP7A downregulation is associated with reduced ECM-adhesion signaling interactions in keratinocytes, as indicated by CellChat. This analysis provides new clues to the mechanism of photodamage and suggests that ATP7A may be involved in the functional regulation of skin photodamage.
Efficacy and Safety of Sonidegib in the Treatment of Multiple Facial Cutaneous Basal Cell Carcinomas with Chronic Renal Insufficiency: A Case Report.
Jing W, Yang J, Gong Z … +4 more , Lei W, Zhang Z, Rao WB, Ai Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42311335 · Full text
Basal cell carcinoma (BCC) is one of the most common malignant skin tumors. Most BCCs can be effectively treated with surgical resection. Hedgehog signaling pathway inhibitors (HHIs) are effective systemic treatment opti...
Basal cell carcinoma (BCC) is one of the most common malignant skin tumors. Most BCCs can be effectively treated with surgical resection. Hedgehog signaling pathway inhibitors (HHIs) are effective systemic treatment options for patients with locally advanced or metastatic BCC who are unsuitable for radical surgery. However, evidence-based guidelines for managing advanced or metastatic BCC are limited, particularly regarding treatment safety in patients with chronic renal insufficiency. Here, we report a case of a patient with multiple facial BCCs complicated by chronic renal insufficiency who was treated with sonidegib. This case demonstrates that sonidegib may be a safe and effective therapeutic option for inoperable cutaneous BCC in patients with chronic renal insufficiency.
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