Searches
/
Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal Of Sichuan University. Medical Science Edition[JOURNAL]
Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal Of Sichuan University. Medical Science Edition[JOURNAL]
Sun
200 papers
[ Targets miR-4429 to Regulate Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma 6-10B Cells].
Zhang Y, Zhang B, Ding Y
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369701 · Full text
OBJECTIVE: To determine whether circular RNA forkhead box protein P1 () regulates the proliferation, migration and invasion of nasopharyngeal carcinoma 6-10B cells by targeting miR-4429. METHODS: The correlations of and...
OBJECTIVE: To determine whether circular RNA forkhead box protein P1 () regulates the proliferation, migration and invasion of nasopharyngeal carcinoma 6-10B cells by targeting miR-4429. METHODS: The correlations of and miR-4429 with pathological characteristics of nasopharyngeal carcinoma patients were analyzed. Nasopharyngeal carcinoma 6-10B cells were transfected with si-NC, si-circFOXP1, pcDNA, pcDNA-circFOXP1, miR-NC, miR-4429 mimics, or co-transfected with si-circFOXP1 and anti-miR-NC, or si-circFOXP1 and anti-miR-4429. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect and miR-4429 expression in nasopharyngeal carcinoma tissues. Cell viability, colony formation, migration and invasion abilities were assessed by Cell Counting Kit-8 (CCK-8), colony formation, wound healing and Transwell assays. Western blotting was used to detect E-cadherin and N-cadherin protein expression. A dual-luciferase reporter assay verified the targeting relationship between and miR-4429. RESULTS: The expression level of in nasopharyngeal carcinoma tissues (4.61 ± 0.31) was significantly higher than that in adjacent tissues (1.00 ± 0.05) ( < 0.001), while the expression level of miR-4429 (0.37 ± 0.03) was significantly lower than that in adjacent tissues (1.00 ± 0.08) ( < 0.001). The expression of miR-4429 was correlated with tumor volume and TNM stage ( < 0.05), while the expression of was correlated with TNM stage( < 0.05) but not with tumor volume ( > 0.05). Inhibition of expression or overexpression of miR-4429 reduced cell viability, colony formation number, wound healing rate, invasive cell number and N-cadherin protein expression, while increased E-cadherin protein expression in nasopharyngeal carcinoma 6-10B cells ( < 0.05). targeted and negatively regulated miR-4429 expression. Interference with miR-4429 reversed the inhibitory effects of silencing on proliferation, migration and invasion of nasopharyngeal carcinoma cells ( < 0.05). CONCLUSION: Inhibition of expression can attenuate the proliferation, migration and invasion of nasopharyngeal carcinoma 6-10B cells by targeting miR-4429.
[The Impact of Parents' Autonomous Support on the Self-Identity of Adolescent Patients With Depression].
Liu Y, Liu H, Meng L … +3 more , Xin B, Yu M, Li Y
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369700 · Full text
OBJECTIVE: From the perspective of patients' self-identity, this article explores the correlations among coping strategies of adolescent patients with depression, parents' autonomous support, and self-identity, and also...
OBJECTIVE: From the perspective of patients' self-identity, this article explores the correlations among coping strategies of adolescent patients with depression, parents' autonomous support, and self-identity, and also examines the mediating role of coping strategies. METHODS: A total of 240 adolescent patients with depression from the First Hospital of Hebei Medical University were selected between August 2023 and July 2024. Basic information questionnaires, the Simplified Coping Style Questionnaire (SCSQ), the Parental Autonomy Support Scale (PASS), and the Self-Identity Scale (SIS) were used for the survey. Pearson correlation analysis was conducted to examine the relationships among coping styles of adolescent patients with depression, parental autonomy support, and self-identity. The SPSS macro program Process 4.1 was used to analyze the mediating role of coping styles between parental autonomy support and self-identity. RESULTS: A total of 240 questionnaires were distributed in this study, and 236 valid questionnaires were collected, resulting in a recovery rate of 98.33%. The mean score for positive coping strategies among 236 adolescent patients with depression was (19.45 ± 2.68) points, while the mean score for negative coping strategies was (18.97 ± 5.04) points. The mean PASS score was (42.73 ± 9.98) points, and the mean SIS score was (48.64 ± 7.73) points. Pearson correlation analysis showed that positive coping strategies were positively correlated with parental autonomous support and self-identity ( = 0.267, 95% CI: 0.154-0.381; = 0.207, 95% CI: 0.098-0.317). Negative coping strategies were negatively correlated with parental autonomous support and self-identity ( = －0.173, 95% CI: －0.290 to －0.054; = －0.153, 95% CI: －0.265 to －0.039). Parental autonomous support was positively correlated with self-identity ( = 0.182, 95% CI: 0.052-0.313). The bootstrap method confirmed three mediating paths: Path 1 (parental autonomous support → positive coping → self-identity) had an effect value of 0.070 (95% CI: 0.021-0.162), accounting for 17.68% of the effect; Path 2 (parental autonomous support → negative coping → self-identity) had an effect value of 0.020 (95% CI: 0.005-0.042), accounting for 5.05% of the effect; Path 3 (parental autonomous support → positive coping → negative coping → self-identity) had an effect value of 0.017 (95% CI: 0.005-0.033), accounting for 4.29% of the effect. The 95% confidence intervals did not include 0, indicating that the indirect effects were significant. CONCLUSION: Parental autonomous support can directly affect the self-identity of adolescent patients with depression and can also indirectly influence it through coping strategies. Positive coping strategies mediate the beneficial effect of parental autonomous support on self-identity and play a protective role.
[Burden of Diabetic Kidney Disease at Global, Regional, and National Levels From 1990 to 2021].
Ning Y, Zhou X, Wang G … +2 more , Zhang L, Wang J
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369699 · Full text
OBJECTIVE: Based on the Global Burden of Diseases (GBD) 2021 data, this study systematically analyzed the trends in the disease burden of diabetic kidney disease (DKD) and predicted its burden over the next decade in 204...
OBJECTIVE: Based on the Global Burden of Diseases (GBD) 2021 data, this study systematically analyzed the trends in the disease burden of diabetic kidney disease (DKD) and predicted its burden over the next decade in 204 countries and regions worldwide from 1990 to 2021. METHODS: Data on DKD from the GBD study spanning 1990 to 2021 were analyzed for trends using age-standardized rates (ASRs) and average annual percentage change (AAPC). The Joinpoint Regression Model (JRM) was applied to identify turning points, and the Autoregressive Integrated Moving Average (ARIMA) model was used to forecast future trends. Statistical analysis was performed using R software. RESULTS: The age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) of global DKD from 1990 to 2021 showed substantial increases, with cumulative rises of 55.0% (95% CI: 42.3% to 69.8%, < 0.001) and 57.3% (95% CI: 43.1% to 73.5%, < 0.001), respectively. The age-standardized prevalence rate (ASPR) declined by 37.5% (95% CI: －45.2% to －28.8%, < 0.001), while the age-standardized disability-adjusted life years (DALYs) rate rose by 56.2% (95% CI: 42.8% to 71.5%, < 0.001). Noticeable disparities in disease burden were observed among countries and regions. Greenland experienced the largest increase in ASPR, whereas the United Kingdom had the most substantial decrease. Estonia had the highest rise in ASIR, while Ireland saw the greatest decline. The United States had the most pronounced increase in ASDR, while the Maldives had the largest decrease. East Asia had the highest number of current cases, while South Asia bore the heaviest burden of new cases and DALYs. The increase was more prominent in regions with a low socio-demographic index (SDI). Projections for the next decade (2022-2031) indicate that the global ASPR of DKD will increase by an average of 0.45% per year (95% CI: 0.21% to 0.69%), the ASIR will decrease by an average of 0.23% per year (95% CI: －0.47% to －0.01%), and the age-standardized DALYs rate will increase by an average of 1.12% per year (95% CI: 0.89% to 1.35%). The overall burden of the disease is expected to continue growing. CONCLUSION: The global burden of DKD is steadily increasing, and it is especially severe in regions with low SDI. It is essential to implement targeted prevention and control measures in high-burden areas to provide a scientific basis for allocating public health resources.
[Study on the Mechanism by Which Atorvastatin Enhances the Stability of Atherosclerotic Plaques in ApoE Mice Through Regulation of MMP-7/Gα13].
Lu X, Zheng R, Chen Y … +1 more , Feng Y
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369698 · Full text
OBJECTIVE: To explore the pleiotropic molecular mechanisms by which atorvastatin (Ator) regulates atherosclerosis (AS) in ApoE mice. METHODS: Thirty 8-week-old male ApoE mice were induced to develop atherosclerosis by a...
OBJECTIVE: To explore the pleiotropic molecular mechanisms by which atorvastatin (Ator) regulates atherosclerosis (AS) in ApoE mice. METHODS: Thirty 8-week-old male ApoE mice were induced to develop atherosclerosis by a high-fat diet. They were randomly assigned to a control group (normal saline), a low-dose Ator group (5 mg/[kg·d]), and a high-dose Ator group (10 mg/[kg·d]), and received interventions for 10 weeks. The primary outcome indicators were assessed by Oil Red O and HE staining to measure the area of atherosclerotic plaques. Secondary outcome indicators included serum lipid levels detected by a blood chemical analyzer, Masson and Sirius Red staining combined with polarized light to assess plaque stability indicators (collagen fiber content, fibrous cap thickness), immunohistochemistry to detect the expression of α-smooth muscle actin (α-SMA) and CD68, fluorescence microplate reader to measure reactive oxygen species (ROS) levels, Western blot and RT-qPCR to detect protein and gene expression of inflammation, oxidative stress, apoptosis-related molecules, matrix metallopeptidase 7 (MMP-7), and guanine nucleotide-binding protein subunit α-13 (Gα13). RESULTS: Blood lipids and plaques: Ator reduced serum low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG) levels ( < 0.05), and dose-dependently decreased the area of aortic lipid deposition and plaque area (Control group: plaque area [1.62 ± 0.15] mm², Low-dose group: [1.13 ± 0.06] mm², High-dose group: [0.83 ± 0.07] mm², < 0.001). Plaque stability: Ator increased collagen fiber content ( < 0.001), increased fibrous cap thickness, upregulated α-SMA expression, and downregulated CD68 expression ( < 0.001). Oxidative stress: Ator remarkably diminished the levels of ROS in arterial tissue and malondialdehyde (MDA) in serum ( < 0.001). Molecular mechanism: Ator downregulated pro-inflammatory factors (tumor necrosis factor-alpha [TNF-α], interleukin-6 [IL-6]), NLRP3, pro-apoptotic proteins (caspase-3, p53), inducible nitric oxide synthase (iNOS), and MMP-7; and upregulated anti-apoptotic protein Bcl-2, antioxidant proteins [mitochondrial deacetylase 3 (sirtuin 3, SIRT3)/superoxide dismutase 2 (SOD2)], and Gα13 ( < 0.001). The expression trends of these proteins and genes were consistent, with a more significant effect in the high-dose group. CONCLUSION: Atorvastatin exerts its anti-atherosclerotic effects by regulating blood lipids, inhibiting inflammatory responses, reducing oxidative stress, and regulating apoptosis. It also affects the expression of MMP-7 and Gα13.
[Analysis of Factors Affecting Endoscopic Follow-up Compliance in High-Risk Patients With Early Gastrointestinal Cancer].
Han L, Lu Y, Xu H
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369697 · Full text
OBJECTIVE: The random forest method was used to analyze the relationship between disease perception, doctor-patient communication, cognitive load, and the compliance of high-risk patients with early digestive tract cance...
OBJECTIVE: The random forest method was used to analyze the relationship between disease perception, doctor-patient communication, cognitive load, and the compliance of high-risk patients with early digestive tract cancer regarding endoscopic re-examination. METHODS: A total of 303 patients at high risk for early digestive tract cancer from January 2022 to December 2022 were selected as research subjects. Questionnaire surveys were conducted using general information questionnaires, a simplified disease perception questionnaire, a doctor-patient communication evaluation scale, and various cognitive load scales. Spearman analysis was used to examine the relationships among disease perception, doctor-patient communication, cognitive load, and compliance with endoscopic reexamination in patients at high risk for early digestive tract cancer. Multivariate logistic analysis was performed to identify factors influencing patients' compliance with endoscopic reexamination. A random forest model was used to rank the importance of characteristic variables for compliance. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate model efficacy, and five-fold cross-validation was applied for validation. RESULTS: Spearman analysis showed that poor compliance with endoscopic re-examination among patients at high risk for early digestive tract cancer was negatively correlated with disease perception and doctor-patient communication ( = －0.788, －0.815, < 0.05), and positively correlated with cognitive load ( = 0.619, < 0.05). Multivariate logistic analysis identified age (odds ratio [OR] = 1.159, 95% confidence interval [CI]: 1.052-1.276), family history of digestive tract tumors (OR = 0.081, 95% CI: 0.008-0.865), average monthly family income (OR = 0.994, 95% CI: 0.991-0.997), disease perception (OR = 0.745, 95% CI: 0.639-0.870), doctor-patient communication (OR = 0.694, 95% CI: 0.602-0.801), and cognitive load (OR = 1.351, 95% CI: 1.136-1.608) as factors influencing compliance with endoscopic re-examination in these patients ( < 0.05). The variable importance ranking in the random forest model was doctor-patient communication > disease perception > cognitive load > average monthly family income > age > family history of digestive tract tumors. The model's prediction AUC was 0.899 (95% CI: 0.843-0.921), and the average accuracy after five-fold cross-validation was 0.893. CONCLUSION: Disease perception, doctor-patient communication, cognitive load, average monthly household income, age, and family history of digestive tract tumors are key factors influencing compliance with endoscopic re-examination in patients with early digestive tract cancer.
[Investigation of Factors Influencing the Quality of Life in Patients With Chemotherapy-Induced Peripheral Neuropathy and Construction of a Prediction Model].
Hong H, Mo L, Sun Y … +1 more , Wu F
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369696 · Full text
OBJECTIVE: To investigate the factors influencing quality of life in patients with chemotherapy-induced peripheral neuropathy (CIPN) and to construct a risk prediction model. METHODS: Patients with CIPN admitted to our h...
OBJECTIVE: To investigate the factors influencing quality of life in patients with chemotherapy-induced peripheral neuropathy (CIPN) and to construct a risk prediction model. METHODS: Patients with CIPN admitted to our hospital from January 2022 to December 2024 were selected. Based on the mean score of the Functional Assessment of Cancer Therapy-General (FACT-G) scale, 262 patients were divided into good quality of life group and poor quality of life group. Clinical data were compared between the two groups. Binary logistic regression was used to identify factors influencing quality of life, and a nomogram prediction model was constructed. The predictive performance of the model was evaluated using receiver operating characteristic (ROC) curve, calibration curve, Hosmer-Lemeshow goodness-of-fit test, and decision curve analysis. RESULTS: The 262 patients were divided into a good group (135 cases) and a poor group (127 cases) based on the mean FACT-G score of 84.65 ± 13.65. Multivariate analysis showed that marital status (odds ratio [OR] = 2.317, 95% CI: 1.037-5.176), renal dysfunction (OR = 2.635, 95% CI: 1.197-5.801), tumor TNM stage T2 (OR = 2.744, 95% CI: 1.095-6.878), stage T3 (OR = 0.301, 95% CI: 0.110-0.828), anxiety (OR = 2.763, 95% CI: 1.260-6.060), pain (OR = 4.651, 95% CI: 1.998-10.828), vomiting (OR = 3.459, 95% CI: 1.567-7.637), insomnia (OR = 5.215, 95% CI: 1.789-15.197), and somnolence (OR = 3.870, 95% CI: 1.387-10.795) were independent influencing factors for quality of life in CIPN patients (all < 0.05).The nomogram prediction model was established based on the above factors. In the training cohort, the AUC of the ROC curve was 0.864 (95% CI: 0.813-0.915). The specificity and sensitivity corresponding to the optimal cut-off value were 0.827 (95% CI: 0.752-0.901) and 0.741 (95% CI: 0.648-0.834), respectively. In the validation cohort, the AUC was 0.803 (95% CI: 0.707-0.900), with a specificity of 0.703 (95% CI: 0.555-0.850) and a sensitivity of 0.738 (95% CI: 0.605-0.871) at the optimal cut-off value, suggesting good diagnostic efficacy of the model. The ideal curve aligns well with the calibration curve, and the Hosmer-Lemeshow test indicates that the model is well calibrated. Decision curve analysis demonstrated a high net benefit of the model within the range of 0.5 to 1.0. CONCLUSION: Marital status, renal dysfunction, tumor TNM staging, anxiety, pain, vomiting, insomnia, and somnolence are factors associated with a lower quality of life in patients with CIPN. The prediction model constructed based on these factors exhibits good discrimination and calibration, which can facilitate clinical assessment of quality of life in CIPN patients.
[Legal Risks and Regulatory Pathways for the Application of Health and Medical Big Data].
Yang J, Fang Y, Kuang Y … +2 more , Zhang W, Hu Y
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369695 · Full text
As health and medical big data is elevated to a "national key strategic resource," its legal significance in public health governance, individual rights protection, and resource allocation optimization has become increas...
As health and medical big data is elevated to a "national key strategic resource," its legal significance in public health governance, individual rights protection, and resource allocation optimization has become increasingly prominent. The World Health Organization (WHO) states that digital health development should adhere to the principles of ethics, security, equity, and sustainability, with data governance serving as critical support for realizing the universal right to health. China has issued the , which incorporates high-risk areas such as life and health, public order, and algorithmic decision-making into a full-process ethical review, thereby initially establishing a dual regulatory framework of "rule of law + ethics." However, a structural tension remains between technological logic and rule-of-law values. In the application of health and medical big data, multiple risks have gradually emerged, including de-anonymization failures, algorithmic discrimination, imbalances in data-related interests, and ethical misconduct. In light of this, from a scenario-based perspective, this paper systematically identifies the core legal risks and proposes regulatory pathways such as classified and graded protection, dynamic anonymization, algorithm auditing, and the return of public interests, aiming to safeguard human dignity and public health security in the digital era while unlocking the value of data.
[Capacity Management During the Hospital-to-Home Transition Period for Patients With Chronic Heart Failure].
Meng G, You M, Guo Z … +3 more , Tao X, Chen J, Li L
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369694 · Full text
OBJECTIVE: Exploring the effects of the hospital-to-home transitional capacity management plan in patients with chronic heart failure. METHODS: Patients with chronic heart failure who were hospitalized from December 2022...
OBJECTIVE: Exploring the effects of the hospital-to-home transitional capacity management plan in patients with chronic heart failure. METHODS: Patients with chronic heart failure who were hospitalized from December 2022 to August 2024 were selected as research subjects and randomly assigned to either a control group or an observation group, with 96 cases in each group. The control group received the conventional nursing plan, while the observation group received the hospital-to-home transitional volume management plan. The main outcome indicator was the rate of achieving dry weight targets two months after discharge. Secondary outcome indicators included self-care ability, and other outcome indicators included 6-minute walking distance and readmission rate. These outcomes were compared between the two groups. RESULTS: Two months after discharge, the rate of achieving normal body weight in the observation group was higher than in the control group ( < 0.05), The 6-minute walking distance in the observation group was greater than in the control group ( < 0.05), The scores for self-care maintenance, self-care management, and self-care confidence in the observation group were all higher than those in the control group ( < 0.05), and the readmission rate in the observation group was lower than that in the control group ( < 0.05). CONCLUSION: The hospital-family transitional volume management program enhance the self-capacity management ability of patients with chronic heart failure, stabilize the volume load status, and provide a reference for self-capacity management of patients with chronic heart failure.
[Expert Consensus on the Development of Public Oral Health Culture in China].
Oral Culture Professional Committee Of The China Popular Culture S
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369693 · Full text
This expert consensus systematically reviews the current status and future directions of oral health culture in China, providing a clear theoretical framework for "oral health culture," including its conceptual definitio...
This expert consensus systematically reviews the current status and future directions of oral health culture in China, providing a clear theoretical framework for "oral health culture," including its conceptual definition, disciplinary perspective, and core values. It analyzes the current state and challenges of oral health culture. The consensus highlights that under the guidance of the "Healthy China" strategy, China's residents have experienced steady improvements in oral health literacy and access to healthcare services, yet still face challenges such as uneven regional development, an incomplete prevention and treatment system, and insufficient integration of oral health into daily cultural practices. Based on multidisciplinary expert discussions and the nominal group technique, the consensus proposes development goals, basic principles, implementation pathways, safeguard measures, and recommendations for oral health culture. First, establish a Chinese-style oral health culture system by integrating oral health culture into public health policies, primary healthcare services, and the national education system. Second, shift the focus from "treatment" to "prevention," strengthening whole-life-cycle oral health management, with particular attention to children, the elderly, and vulnerable groups. Third, leverage digital and new media technologies to innovate health communication formats, creating scientific, accessible, and positive oral health cultural products to foster a societal atmosphere of "caring for teeth." Fourth, incorporate oral health culture indicators into the evaluation systems for healthy cities and communities. The consensus emphasizes that the development of oral health culture is a crucial foundation for achieving universal oral health, requiring collaborative efforts from the government, professional institutions, media, schools, families, and the public.
[Development and Application of a Method for Determining 33 Aromatic Primary Amines in Medical-Grade Thermoplastic Polyurethane by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry].
Yang Y, Yang J, Xiao Y … +5 more , Hu L, Cheng J, Guo Y, Jiang Y, Zhao D
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369692 · Full text
OBJECTIVE: To develop an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of 33 aromatic primary amines in medical-grade thermoplastic polyureth...
OBJECTIVE: To develop an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of 33 aromatic primary amines in medical-grade thermoplastic polyurethane (TPU). METHODS: The target compounds were extracted using 80% methanol and PBS solution containing 10% ethanol as the solvents. The 80% methanol extract was filtered through and diluted to one-fifth of the original concentration. The PBS extract was processed through an HLB solid-phase extraction column (3 mL, 60 mg, methanol and water equilibrium), eluted with 5 mL methanol, filtered, and diluted to 5 mL with methanol. Then, analysis was performed using UPLC-MS/MS. Chromatographic separation was performed using an Agilent InfinityLab Poroshell 120 EC-C18 column (150 mm × 3.0 mm, 2.7 μm) with methanol (A) and deionized water containing 0.1% formic acid (B) as the mobile phases. Gradient elution was conducted with a column temperature of 40 ℃, a flow rate of 0.2 mL/min, and an injection volume of 1 μL. Mass spectrometry analysis was performed using an electro-spray ionization (ESI) source in multiple reaction monitoring (MRM) positive ion mode. The standard curves, quantification limits, precision, recovery rates, and matrix effects of the method under different extraction conditions were evaluated. RESULTS: The 33 aromatic primary amines analyzed in the study showed good linearity ( > 0.998) within the 2-100 ng/mL concentration range. Detection limits ranged from 0.1 to 0.5 ng/mL, and quantification limits ranged from 0.3 to 1.7 ng/mL. Recovery rates for the 33 aromatic primary amines in 80% methanol samples ranged from 70.7% to 116.0%. Recovery rates for 31 aromatic primary amines in PBS samples containing 10% ethanol ranged from 74.9% to 113.8%. The intra-day and inter-day precision for different samples was both less than 10%, indicating good sample stability. Analysis of aromatic primary amine content in sample extracts using this method revealed that methylenedianiline (MDA) was detected in all 6 initially tested samples. Under simulated extraction at 37 ℃ and accelerated extraction at 60 ℃, 3 samples exhibited continuous or delayed MDA release. 2,4'-MDA was detected in 2 samples during the initial limit extraction phase and remained detectable in 1 sample under 60 ℃ accelerated aging conditions, but no release was observed under the 37 ℃ simulated physiological environment. 2,2'-MDA was detected only in two samples during initial limit extraction and was not released in subsequent simulated or accelerated extraction processes. CONCLUSION: The UPLC-MS/MS method demonstrates high sensitivity and accuracy, meeting the requirements for precise detection of 33 aromatic primary amines in medical-grade TPU and providing reliable technical support for risk assessment and quality control of aromatic primary amines in these materials and products.
[Clinical Study of Robotic Natural Orifice Specimen Extraction Surgery for Right Colon Cancer].
Liu D, Zhou R, Xiao F … +5 more , Hu W, He P, Gao G, Liang Y, Li T
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369691 · Full text
OBJECTIVE: To evaluate the safety and feasibility of robotic natural orifice specimen extraction surgery (NOSES) for right colon cancer. METHODS: Twenty-two female patients undergoing this procedure between January 1, 20...
OBJECTIVE: To evaluate the safety and feasibility of robotic natural orifice specimen extraction surgery (NOSES) for right colon cancer. METHODS: Twenty-two female patients undergoing this procedure between January 1, 2022 and January 31, 2025 were enrolled. Safety and feasibility were assessed by analyzing operative time, intraoperative blood loss, conversion rate to open surgery, postoperative complications, 30-day mortality, and 30-day unplanned surgery-related readmission rate. RESULTS: All procedures were completed successfully. The median operative time was 158 min (152-169 min), and the median blood loss was 53 mL (43-75 mL). No conversions to open surgery occurred. The first postoperative flatus occurred at a median of 53.00 h (49.25-57.50 h), and the median postoperative hospital stay was 9.00 d (8.00-11.00 d). Postoperative complications included one case of intestinal obstruction. No anastomotic leakage, anastomotic bleeding, vaginal hemorrhage, vaginal infection, or abdominal infection was observed. There were no deaths within 30 days and no unplanned surgery-related readmissions. CONCLUSION: Robotic NOSES for right colon cancer is safe and feasible.
[Ethical and Humanistic Reflections on the Use of Remote Robotic Laparoscopic Surgery in Gynecology].
Wang N, Meng Y
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369690 · Full text
As a pioneering development in modern gynecology, telerobotic laparoscopic surgery overcomes geographical barriers and optimizes resource allocation. However, its inherent "de-presence" has also raised significant ethica...
As a pioneering development in modern gynecology, telerobotic laparoscopic surgery overcomes geographical barriers and optimizes resource allocation. However, its inherent "de-presence" has also raised significant ethical challenges and philosophical questions. Based on the practical application of remote technologies in gynecological surgery, this study first examines how network latency affects the safety of delicate pelvic anatomical dissections, considering the "ethicization" of technical parameters. Next, it analyzes the reconstruction of the responsibility chain - including the lead surgeon, on-site assistants, equipment manufacturers, and telecommunication providers - while clarifying the boundaries of legal liability among these stakeholders. Additionally, from the perspectives of both clinicians and patients, this paper discusses the heightened professional responsibility and cognitive anxiety under the "technological halo," as well as patients' expectations and concerns about their bodies being mediated by technology. To address these challenges, the study proposes establishing a "Techno-Humanistic Dual-Gate" ethical review system and emphasizes the importance of upholding the spirit of medical humanities. These measures aim to ensure that telerobotic surgery develops in a healthy manner by integrating technological precision with humanistic care.
[Study of the Correlation Between MRI Parameters, Microvascular Density, and Prognosis in Glioma].
Nan Y, Lu J, Peng S
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369689 · Full text
OBJECTIVE: To analyze the correlations between multimodal MRI examination parameters - apparent diffusion coefficient (ADC), cerebral blood flow (CBF), and choline (Cho)/creatine (Cr)-and microvessel density (MVD) in pat...
OBJECTIVE: To analyze the correlations between multimodal MRI examination parameters - apparent diffusion coefficient (ADC), cerebral blood flow (CBF), and choline (Cho)/creatine (Cr)-and microvessel density (MVD) in patients with glioma, as well as the prognostic value of these parameters. METHODS: The medical records of 200 patients diagnosed with glioma at our hospital from January 2019 to January 2024 were retrospectively analyzed. According to the WHO classification, patients were divided into a low-grade group ( = 122) and a high-grade group ( = 78). Patients were further divided into a good prognosis group ( = 114) and a poor prognosis group ( = 86). The Pearson correlation test was used to analyze the relationship between multimodal MRI parameters and MVD in glioma patients. The area under the curve (AUC) of receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of multimodal MRI parameters and MVD for high-grade glioma and their predictive value for poor prognosis. The Hosmer-Lemeshow test was used to assess the goodness of fit of the model. RESULTS: The ADC value in the low-grade group was higher than in the high-grade group, while CBF, Cho/Cr, and MVD were lower in the low-grade group ( < 0.05). The ADC value in the good prognosis group was higher than in the poor prognosis group, while CBF and Cho/Cr values were lower in the poor prognosis group ( < 0.05). ADC was negatively correlated with MVD in glioma patients ( = －0.226, = 0.001); CBF and Cho/Cr were positively correlated with MVD ( = 0.235 and 0.396, = 0.001 and < 0.001, respectively). The AUCs of ADC, CBF, Cho/Cr, and MVD for diagnosing high-grade glioma were 0.870, 0.696, 0.926, and 0.950, respectively. The combined AUC of these four parameters was 0.997. For prognosis prediction based on multimodal MRI parameters, the combined AUC of ADC+CBF+Cho/Cr was 0.876, while the AUCs of ADC, CBF, and Cho/Cr alone were 0.718, 0.688, and 0.808, respectively. The Hosmer-Lemeshow test showed that the combined model (ADC + CBF + Cho/Cr) fit was good ( = 8.570, = 0.380), indicating that the combined prediction model had high accuracy. CONCLUSION: ADC, CBF, and Cho/Cr have a weak correlation with MVD in glioma patients. The combination of these four parameters has high value in diagnosing high-grade glioma, and the combination of the first three parameters has higher predictive value for patient prognosis.
[Active Oxygen Influences Foam Macrophage Formation by Regulating Peroxisome Proliferator-Activated Receptor-γ Expression].
Liu J, Ye Y, Su R … +2 more , Huang Z, Li J
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369688 · Full text
OBJECTIVE: To investigate the effect of reactive oxygen species (ROS) on foam macrophage formation by regulating the expression of peroxisome proliferator-activated receptor-γ (PPARγ). METHODS: From June 2018 to December...
OBJECTIVE: To investigate the effect of reactive oxygen species (ROS) on foam macrophage formation by regulating the expression of peroxisome proliferator-activated receptor-γ (PPARγ). METHODS: From June 2018 to December 2021, human blood samples were obtained from 30 healthy donors, and peripheral blood mononuclear cells (PBMCs) were isolated. The PBMCs were differentiated into human monocyte-derived macrophages (HMDMs) and subsequently infected with Mycobacterium tuberculosis H37Ra strain to establish an in vitro human macrophage infection model. ROS production was modulated using N-acetylcysteine (NAC) and emodin, while PPARγ activity was regulated using the PPARγ agonist (BRL49653) or antagonist (GW9662). The effects of H37Ra infection on intracellular ROS production and lipid formation in macrophages, as well as the impact of ROS generation on foam macrophage formation, were assessed using 2', 7'-dichlorodihydrofluorescein diacetate (DCFH2-DA) and Oil Red O staining. The influence of ROS production on PPARγ expression in macrophages was examined by qRT-PCR and Western blot. Furthermore, the involvement of PPARγ activity in ROS-mediated regulation of foam macrophage formation was investigated by modulating PPARγ activity. RESULTS: The results of Oil Red O staining and DCFH2-DA detection showed that, compared with the control group, H37Ra infection promoted ROS production in HMDMs and induced foam cell formation, with statistically significant differences ( < 0.01). After treating HMDMs with NAC or emodin for 1 hour and then infecting with H37Ra, NAC treatment reduced intracellular ROS levels and lipid content, while emodin increased intracellular ROS levels and lipid content, both with statistically significant differences ( < 0.01). Western blot analysis indicated that H37Ra infection inhibited PPARγ production, NAC promoted PPARγ expression, and emodin inhibited PPARγ expression, with statistically significant differences ( < 0.05). Pre-treating HMDMs with BRL49653 or GW9662 for 1 hour before H37Ra infection showed that GW9662 promoted lipid accumulation in the cells, with statistically significant differences ( < 0.01). CONCLUSION: ROS can promote the formation of foam macrophages by downregulating the expression of PPARγ.
A Review of Robotic vNOTES Surgery: Current Applications, Advantages, and Future Directions.
Lovell DY, Yang Q, Guan X
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369687 · Full text
Over the past 500 years, the convergence of three distinct paths - vaginal surgery, laparoscopy, and robotic technologies - has enabled the development of robot-assisted vaginal natural orifice transluminal endoscopic su...
Over the past 500 years, the convergence of three distinct paths - vaginal surgery, laparoscopy, and robotic technologies - has enabled the development of robot-assisted vaginal natural orifice transluminal endoscopic surgery (RA-vNOTES). The ongoing evolution of vaginal surgery has led to contemporary procedures such as hysterectomy, myomectomy, sacrocolpopexy, adnexal interventions, and oncologic operations, applicable to a wide range of diagnoses and pathologies. This approach offers patients significant benefits, including superior cosmetic outcomes, less pain, lower infection rates, and faster recovery of baseline quality of life. Surgeons benefit from improved ergonomics, better visualization, the ability to use multiple instruments, and enhanced tremor control. Robotic assistance has greatly expanded the ability to safely perform more complex cases, such as excision of stage 4 endometriosis with complete posterior cul-de-sac obliteration, as well as other procedures previously considered contraindicated in traditional vaginal surgery. Here, we present current findings and advances in RA-vNOTES and consider future developments in robotic surgery aimed at further improving minimally invasive techniques.
[Application and Reflection of Artificial Intelligence in Pharmacy Education].
Liu W, Huang T, Ke B … +1 more , Sun Q
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369686 · Full text
Although the comprehensive, multi-level, and wide-ranging integration of artificial intelligence (AI) with pharmaceutical science has greatly advanced the development of the discipline, the majority of pharmaceutical pro...
Although the comprehensive, multi-level, and wide-ranging integration of artificial intelligence (AI) with pharmaceutical science has greatly advanced the development of the discipline, the majority of pharmaceutical professionals still have limited knowledge about the applications of AI in pharmacy. Particularly in recent years, the rapid development of generative AI technologies represented by large language models has introduced new paradigms for pharmaceutical knowledge acquisition, drug information mining, and intelligent education. Simultaneously, interdisciplinary talents in "AI + Pharmacy" play a crucial and irreplaceable role in the new drug development process.Faced with this reality, pharmaceutical educators should uphold the core philosophy of "AI empowerment, education first," actively disseminate cutting-edge AI concepts, and vigorously develop interdisciplinary advantages to address challenges in traditional pharmaceutical education. The core goal of cultivating innovative talents in "AI + Pharmacy" is to to nurture interdisciplinary professionals with solid pharmaceutical expertise, strong computational and data-driven thinking, and the ability to comprehensively apply AI technologies to solve complex problems in real-world research and application scenarios. To this end, his paper proposes a three-pillar "AI + Pharmacy" innovative talent cultivation model centered on "teaching restructuring, research-driven feedback, and faculty support," aiming to systematically promote comprehensive reforms in pharmaceutical education-from curriculum systems and teaching practices to faculty development. This approach seeks to gradually establish and continuously optimize a new paradigm for interdisciplinary pharmaceutical talent cultivation that aligns with contemporary demands, thereby providing sustainable talent support and innovative momentum for the overall advancement of pharmaceutical science and new drug development.
[Risk Nomogram Prediction Model for Cerebral Edema in Patients With Hypertensive Intracerebral Hemorrhage].
Sun J, Yu M, Huang H … +1 more , Wang Q
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369685 · Full text
OBJECTIVE: To establish and validate a risk prediction model for cerebral edema in patients with hypertensive intracerebral hemorrhage (HICH). METHODS: A total of 320 HICH patients from January 2020 to March 2025 were re...
OBJECTIVE: To establish and validate a risk prediction model for cerebral edema in patients with hypertensive intracerebral hemorrhage (HICH). METHODS: A total of 320 HICH patients from January 2020 to March 2025 were retrospectively selected and divided into a training set ( = 224) and a validation set ( = 96) at a ratio of 7∶3. Based on the occurrence of cerebral edema, the training set was divided into a cerebral edema group ( = 71) and a non-cerebral edema group ( = 153), and the validation set was divided into a cerebral edema group ( = 31) and a non-cerebral edema group ( = 65). LASSO regression was used to screen variables, followed by multivariate logistic analysis, and a nomogram prediction model was established. The model was validated using the receiver operating characteristic (ROC) curve analysis and calibration curve. RESULTS: There were 71 cases (31.70%) in the training set and 31 cases (32.29%) in the validation set with cerebral edema. Statistically significant differences were found in age, hematoma volume, Glasgow Coma Scale (GCS) score, National Institutes of Health Stroke Scale (NIHSS), serum matrix metalloproteinase-9 (MMP-9), angiopoietin-like protein 2 (ANGPTL2), and thrombospondin-1 (TSP-1) levels between the cerebral edema and non-cerebral edema groups ( < 0.05). Multivariate logistic analysis showed that hematoma volume (odds ratio [OR] = 1.227, 95% confidence interval [CI]: 1.115-1.351), GCS (OR = 0.700, 95% CI: 0.569-0.862), NIHSS (OR = 1.176, 95% CI: 1.030-1.342), MMP-9 (OR = 1.017, 95% CI: 1.009-1.026), ANGPTL2 (OR = 3.759, 95% CI: 1.784-7.919), and TSP-1 (OR = 1.097, 95% CI: 1.046-1.149) were influencing factors for cerebral edema in HICH patients ( < 0.05). ROC curve analysis showed that the area under the curve (AUC) of the training set was 0.930 (95% CI: 0.886-0.962), and that of the validation set was 0.952 (95% CI: 0.915-0.990). The calibration curve showed that the prediction curves of the training and validation sets were consistent with the standard curve. CONCLUSION: Hematoma volume, GCS, NIHSS, serum MMP-9, ANGPTL2, and TSP-1 levels are influencing factors for cerebral edema in HICH patients, and the nomogram model constructed based on these factors has demonstrated efficacy.
[A Method for Respiratory Monitoring in Thermal Infrared Video Using Masked Autoencoder Pretraining].
Mao R, Lü X, Zhang W
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 May · PMID 42369684 · Full text
OBJECTIVE: By constructing spatiotemporal maps from thermal infrared videos and applying self-supervised learning methods, temperature change trends in the oral and nasal regions caused by breathing can be automatically...
OBJECTIVE: By constructing spatiotemporal maps from thermal infrared videos and applying self-supervised learning methods, temperature change trends in the oral and nasal regions caused by breathing can be automatically detected, enabling long-term, non-contact breathing monitoring. This offers technical support for early warning of emotions, stress responses, and respiratory system diseases. METHODS: To address the limitations of existing methods in characterizing temperature variation trends in thermal infrared, a two-stage self-supervised reconstruction spatio-temporal graph and downstream fine-tuning method is proposed. First, spatial registration between the ordinary camera and the thermal infrared camera is achieved using an affine transformation matrix, enabling key point tracking and the construction of a spatio-temporal graph. Considering individual differences in the sensitive areas of the respiratory signal, deep representations are initially extracted through self-supervised learning, and the latent vectors are then fine-tuned to adapt to downstream monitoring tasks. Additionally, two new evaluation metrics are introduced: the average absolute error of the ratio of inhaled to exhaled gas volumes and the average absolute error of respiratory duration. RESULTS: The experimental results on the dataset show that this two-stage training method can accurately capture the trend of respiratory signals. The waveform fitting accuracy of end-to-end feature learning is significantly better than that of traditional methods and current popular models. The core performance indicators are as follows: mean absolute error 0.07 ± 0.02, root mean square error 0.69 ± 0.11, Pearson correlation coefficient 0.15 ± 0.04, ratio of inhalation to exhalation volume 0.40 ± 0.12/0.26 ± 0.05, and mean absolute error of respiratory duration 0.79 ± 0.19/0.79 ± 0.10. CONCLUSION: The self-supervised pre-training waveform analysis method based on a masked autoencoder demonstrates advantages in both the frequency and time domains for respiratory monitoring. Additionally, morphological differences in the pulse signal during the respiratory phase were identified. The kurtosis of the photoplethysmography (PPG) signal significantly decreased, and the skewness was reduced during the exhalation phase. This finding offers a new perspective for evaluating cardiopulmonary coupling function and autonomic nerve regulation from the morphological feature dimension of PPG.
[A Study of the Association and Interaction Between Organophosphorus Pesticide Exposure and Insulin Resistance in Non-diabetic Adults].
Zhu X, Wang Z, Zhang Y … +3 more , Li K, Zeng W, Guo B
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 Mar · PMID 42021911 · Full text
OBJECTIVE: To explore the association and interaction between multiple organophosphorus pesticide metabolites and insulin resistance in non-diabetic adults. METHODS: Based on data from the National Health and Nutrition E...
OBJECTIVE: To explore the association and interaction between multiple organophosphorus pesticide metabolites and insulin resistance in non-diabetic adults. METHODS: Based on data from the National Health and Nutrition Examination Survey (NHANES) conducted in the United States from 2003 to 2018, a total of 3395 research subjects were included. After natural logarithmic transformation, multiple linear regression, restricted cubic spline, and quantile-weighted regression models were used to separately evaluate the individual and combined exposure effects of urinary organophosphorus pesticide metabolites on insulin resistance. The analysis focused on exploring the interaction between methyl-type and ethyl-type metabolites. Indicators of insulin resistance included the triglyceride-glucose (TyG) index, triglyceride-glucose-body mass index (TyG-BMI), triglyceride-glucose-waist-to-height ratio (TyG-WHtR), and triglyceride-glucose-waist circumference (TyG-WC). RESULTS: On the natural logarithmic scale, except for dimethylthiophosphate (DMTP), the concentrations of all other organophosphorus pesticide metabolites were positively correlated with TyG-BMI and reached statistical significance ( < 0.05). The values and 95% CI for the methyl group (∑DMAP), ethyl group (∑DEAP), and total exposure (∑DAP) were 0.0041 (95% CI: 0.0005-0.0077), 0.0064 (95% CI: 0.0022-0.0105), and 0.0060 (95% CI: 0.0018-0.0102), respectively. Most of these relationships were linear ( < 0.05, > 0.05). There may be a synergistic effect between the methyl and ethyl group metabolites, but this relationship was not significant. Mixed exposure to organophosphorus pesticide metabolites was positively correlated with TyG-BMI, TyG-WC, and TyG-WHtR. The weight of diethyl dithiophosphate (DEDTP) accounted for more than 50% in different insulin resistance indicators. CONCLUSION: The intake of organophosphorus pesticides may increase indicators used to assess insulin resistance, raising the risk of insulin resistance. Interactions between metabolites may further worsen this effect.
[Efficacy of Ganciclovir Combined With Recombinant Human Interferon α-1b for Viral Encephalitis in Children].
Han B, Zhao L, Han X … +2 more , Kong N, Qin X
Sichuan Da Xue Xue Bao Yi Xue Ban · 2026 Mar · PMID 42021910 · Full text
OBJECTIVE: To explore the efficacy of ganciclovir combined with recombinant human interferon α-1b in the treatment of viral encephalitis in children. METHODS: 160 children with viral encephalitis admitted to third depart...
OBJECTIVE: To explore the efficacy of ganciclovir combined with recombinant human interferon α-1b in the treatment of viral encephalitis in children. METHODS: 160 children with viral encephalitis admitted to third department of pediatrics of Xingtai People' s Hospital were selected, and divided into single group and combined group by random number table method, with 80 cases in each group. The single group was treated with ganciclovir, whereas the combined group was given ganciclovir combined with recombinant human interferon α-1b. Compare the time to recovery of symptoms in patients between groups. After 2 weeks of treatment, compare the clinical efficacy and EEG abnormalities between the two groups. The cerebral hemodynamics (mean blood flow velocity [Vm] and pulsatility index [PI] of anterior cerebral artery and posterior cerebral artery), neurological function (neuron specific enolase [NSE], neurotrophin3 [NT-3], nerve growth factor [NGF]), immune function (immunoglobulin A [IgA], IgG, IgE) and inflammatory factors (tumor necrosis factor α [TNF-α], interleukin β [IL-1β], interleukin 2 [IL-2]) before treatment and after 2 weeks of treatment were compared between groups, and the adverse reactions during treatment were recorded. RESULTS: The disappearance durations of fever, headache, vomiting, convulsion, disturbance of consciousness and meningeal irritation in combined group were shorter than those in single group ( < 0.05). After 2 weeks of treatment, the total effective rate of clinical efficacy was higher in the combined group than in the single group ( < 0.05), the abnormal rate of EEG in the combined group was lower than that in the single group ( < 0.05). There was no statistically significant difference in the clinical effective rate between subgroups with different disease severity between the two groups of children ( > 0.05). The Vm and PI of anterior cerebral artery and posterior cerebral artery and levels of NSE, NGF, IgA, TNF-α, IL-1β and IL-2 were decreased in both groups, and the indicators in combined group were lower compared to single group (all < 0.05). The levels of NT-3, IgG and IgE in both groups were enhanced after 2 weeks of treatment, and the levels were higher in combined group (all < 0.05). There was no significant difference in the total incidence rate of adverse reactions between groups ( > 0.05). CONCLUSION: Ganciclovir combined with recombinant human interferon α-1b can effectively treat viral encephalitis in children, improve cerebral hemodynamics and neurological function, enhance immune function, and relieve inflammatory response, and it dose not increase adverse reactions.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe