Searches / The British Journal Of Dermatology[JOURNAL]

The British Journal Of Dermatology[JOURNAL]

Sun 200 papers

Long-term Particulate Matter Exposure and Risk of Alopecia Areata: A Nationwide Epidemiological Study with Preliminary In Vitro Evidence.

Kim M, Nam J, Lee J … +9 more , Kang S, Heo J, Woo H, Kang SW, Park JY, Huh CH, Cho J, Kang D, Shin JW

Br J Dermatol · 2026 Jun · PMID 42311104 · Publisher ↗

BACKGROUND: Although particulate matter (PM) has been implicated in various systemic and cutaneous diseases, large-scale evidence on whether PM exposure affects the risk of alopecia areata (AA) remains limited. OBJECTIVE... BACKGROUND: Although particulate matter (PM) has been implicated in various systemic and cutaneous diseases, large-scale evidence on whether PM exposure affects the risk of alopecia areata (AA) remains limited. OBJECTIVES: To assess the epidemiologic association between long-term PM exposure and incident AA risk with exploration of potential biological mechanisms. METHODS: In the epidemiologic study, annual average concentrations of fine (PM2.5) and coarse (PM10) PM were linked to individuals who underwent national health screening between 2006 and 2022, and the risk of incident AA, defined as ≥3 outpatient claims with relevant diagnostic codes within a 1-year period, was evaluated. In the preliminary in vitro experiment, human hair outer root sheath (ORS) cells were exposed to varying concentrations of PM10-like fine dust for 24 hours. The expression of inflammatory cytokines was evaluated using quantitative real-time polymerase chain reaction, western blotting, and immunofluorescence analyses. RESULTS: Higher long-term PM2.5 and PM10 exposures were associated with increased risk of incident AA (per 10μg/m3 increase, adjusted HR 1.45, 95% CI 1.39-1.52 for PM2.5 and adjusted HR 1.32, 95% CI 1.28-1.36 for PM10) with the strongest association for alopecia universalis subtype (per 10μg/m3 increase, adjusted HR 2.23, 95% CI 1.83-2.63 for PM2.5 and adjusted HR 1.82, 95% CI 1.58-2.07 for PM10). PM10 exposure increased reactive oxygen species generation, expression of IL-1β, IL-6, IL-8, and IL-15RA, and phosphorylation of p38 and STAT3 in ORS cells. CONCLUSIONS: This study suggests that ambient PM may be a modifiable environmental risk factor for AA through activation of selective inflammatory pathways, underscoring the need for public health efforts to reduce PM exposure and potentially mitigate AA risk.

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Antipsoriatic medications and their safety: why seeking for registry data exploration.

Stephan B

Br J Dermatol · 2026 Jun · PMID 42304614 · Publisher ↗

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Pruritic Rash and Diarrhea in a Man with Chronic Alcohol Use Disorder.

Hu HH, Li JH

Br J Dermatol · 2026 Jun · PMID 42304612 · Publisher ↗

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Microbial diversity as a proxy for skin health: an ecological framework misapplied.

Xia J, Kuzyakov Y, Krutmann J

Br J Dermatol · 2026 Jun · PMID 42304609 · Publisher ↗

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Further Validation and Threshold Determination of Brazilian-Portuguese Version of the CU-Q2oL Questionnaire.

Marcelino J, Aulenbacher F, Pereira H … +9 more , Regateiro F, Todo-Bom A, Leão L, Mota D, Ferreira R, Horta A, Guimarães J, Tomaz E, Metz M

Br J Dermatol · 2026 Jun · PMID 42299909 · Publisher ↗

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In-depth Human Phenotype Ontology Curation Boosts Prioritization Performance for Netherton Syndrome.

Cuperus E, Pasmans SGMA, Han HL … +10 more , Arterbery AS, Danis D, van Geel M, Has C, Weibel L, Hannula-Jouppi K, Bodemer C, Hovnanian A, Robinson PN, van Gijn ME

Br J Dermatol · 2026 Jun · PMID 42299620 · Publisher ↗

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Dermatopathology in 4D: in situ spatial transcriptomics maps the cellular and molecular architecture of skin.

Cheng HC, Cheng JB, Cho RJ … +2 more , McGrath JA, Hsu CK

Br J Dermatol · 2026 Jun · PMID 42294859 · Publisher ↗

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Context, not class, may be the key signal in systemic JAK inhibitor exposure in MF/SS.

He Y, Li C

Br J Dermatol · 2026 Jun · PMID 42288380 · Publisher ↗

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When less is more: The role of dermatologists in promoting societal and self-acceptance of skin health and disease.

Demirel S, McPherson T, Rajan N … +1 more , Affleck A

Br J Dermatol · 2026 Jun · PMID 42287662 · Publisher ↗

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Comment on 'Context, not class, may be the key signal in systemic JAK inhibitor exposure in MF/SS': reply from authors.

Amitay-Laish I, Mitsunaga K, Ortiz-Romero PL … +10 more , de Masson A, Morsia E, Sanches JA, Enz PA, Nikolaou V, Jonak C, Porkert S, Leshem YA, Avitan-Hersh E, Hodak E

Br J Dermatol · 2026 Jun · PMID 42287026 · Publisher ↗

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Insulin resistance in psoriasis: metabolic recalibration and therapeutic prediction; a prospective cohort study at a tertiary referral centre.

Cheung S, Wang H, Wu J … +8 more , Zhang L, Ruan Y, Zhou J, Wang Y, Chen L, Pan M, Li X, Zheng J

Br J Dermatol · 2026 Jun · PMID 42284119 · Publisher ↗

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Expanding histopathological assessment may provide limited prognostic value for metastatic cutaneous squamous cell carcinoma: insights from two nationwide nested case-control studies.

Steijlen OFM, Rentroia-Pacheco B, Tokez S … +5 more , Amir AL, Koppes SA, Hollestein LM, Wakkee M, Mooyaart AL

Br J Dermatol · 2026 Jun · PMID 42276591 · Publisher ↗

BACKGROUND: Multiple refined histopathological variables have been proposed to improve risk stratification of cutaneous squamous cell carcinoma (CSCC) patients, but evidence of their added value over conventional clinico... BACKGROUND: Multiple refined histopathological variables have been proposed to improve risk stratification of cutaneous squamous cell carcinoma (CSCC) patients, but evidence of their added value over conventional clinicopathological variables such as depth of invasion or differentiation grade is limited. OBJECTIVE: To evaluate the association between refined histopathological variables and metastasis in CSCC and their value relative to routinely available variables. METHODS: We conducted two nested case-control (NCC) studies using data from the Netherlands Cancer Registry and nationwide pathology registry with over 10 years of follow-up (n=19,120 patients). The first NCC study included a population-based set of 195 primary CSCCs of metastatic cases matched to 195 primary CSCCs of non-metastatic controls only based on follow-up time. The second NCC study included a metastatic risk-matched set, matching 250 cases with 250 controls based on calculated metastatic risk. Pathologists reviewed all primary CSCCs, including the refined variables: morphological subtype, solar elastosis, peritumoral infiltrate, tumour budding, and mitosis. Analyses were conducted using conditional logistic regression. RESULTS: In the population-based set, multivariable analyses showed no significant associations between refined histopathological variables and metastasis. In the risk-matched set, severe (OR 0.28; 95%CI 0.09-0.87) and moderate (OR 0.20; 95%CI 0.07-0.56) solar elastosis were negatively associated with metastasis. CONCLUSIONS: Most refined histopathological variables may not provide additional prognostic value beyond conventional risk factors for metastasis in CSCC patients. The observed inverse association between solar elastosis and metastasis warrants further research.

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Psoriasis flare-ups in non syndromic autosomal recessive epidermal differentiation disorders.

Assan F, Miskinyte S, Sylvain S … +8 more , Masson Regnault M, Poizeau F, Leclerc-Mercier S, Fischer J, Hovnanian A, Bachelez H, Hickman G, Bourrat E

Br J Dermatol · 2026 Jun · PMID 42274354 · Publisher ↗

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Risk of major adverse cardiovascular events in patients with chronic hand eczema from the Danish National Patient Register.

Christensen MO, Sieborg J, Vittrup I … +6 more , Hamann CR, Olesen C, Zachariae C, Thomsen SF, Egeberg A, Thyssen JP

Br J Dermatol · 2026 Jun · PMID 42274228 · Publisher ↗

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Comparing narrowband and broadband ultraviolet B for atopic dermatitis: new knowledge about an "old" therapy.

Knöps E, Spuls PI

Br J Dermatol · 2026 Jun · PMID 42267665 · Publisher ↗

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Treatments for Pediatric Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Critical Appraisal and Systematic Review.

Chiu YC, Ma SH, Chen TL

Br J Dermatol · 2026 Jun · PMID 42266102 · Publisher ↗

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Engineered Caf1 Constructs Encoding Laminin-332 Motifs: A Novel Approach for Enhanced Cutaneous Wound Healing.

Nie Y, Waller H, Caley MP … +6 more , Peters DT, Young L, Gulati P, Jones EM, Lakey JH, Reynolds NJ

Br J Dermatol · 2026 Jun · PMID 42263674 · Publisher ↗

BACKGROUND: Laminin-332 is a key extracellular matrix (ECM) protein that supports keratinocyte adhesion, migration, and re-epithelialisation during wound healing. Its loss, as in Junctional Epidermolysis Bullosa (JEB) di... BACKGROUND: Laminin-332 is a key extracellular matrix (ECM) protein that supports keratinocyte adhesion, migration, and re-epithelialisation during wound healing. Its loss, as in Junctional Epidermolysis Bullosa (JEB) disrupts re-epithelialization, which highlights its therapeutic relevance. However, direct application of full-length laminin or its fragments is limited by poor stability and high production costs. As an alternative, biomaterial scaffolds are being developed. The Capsular Antigen F1 (Caf1) is one such scaffold, offering a stable, customisable platform for presenting bioactive motifs in a more practical format. OBJECTIVES: To develop stable Caf1 scaffolds displaying laminin-332 motifs and evaluate their therapeutic potential in promoting epithelial repair under both normal and laminin-deficient conditions, with the goal of enabling clinically translatable wound-healing strategies. METHODS: Laminin-332-derived peptide motifs were identified through a systematic literature review and ranked using a scoring system. Leading candidates were engineered into Caf1 and expressed in Escherichia coli. Keratinocyte migration, motility, adhesion and pSMAD2 signalling were assessed in vitro using normal human epidermal keratinocytes and LAMA3-knockdown cells cultured on Caf1-coated plates. An ex vivo human skin wound model was used to assess translational relevance: wounded skin explants were treated with Caf1 constructs and cultured at the air-liquid interface for 7 days. Re-epithelialization and epithelial thickness were evaluated by haematoxylin and eosin staining. RESULTS: Caf1 proteins displaying laminin-332-derived motifs were expressed in E. coli and purified. Among the engineered constructs, Caf1-J3 and Caf1-J4 significantly enhanced keratinocyte migration and single-cell motility in vitro. Combined application further accelerated wound closure, suggesting complementary effects. In LAMA3-deficient keratinocytes, these coatings restored adhesion, promoted actin cytoskeletal organisation, and reduced nuclear pSMAD2 levels. In ex vivo wounded human skin, they also promoted re-epithelialisation and supported homogeneous neo-epidermis formation. CONCLUSIONS: These findings show that short laminin-332-derived motifs, when presented on the Caf1 scaffold, can mimic and partially recover key basement membrane functions in epithelial repair. Caf1-J3 and Caf1-J4 function as minimal bioactive units that restore keratinocyte cell adhesion and modulate key signalling pathways involved in wound healing. This modular protein platform offers a clinically relevant strategy for chronic wounds and ECM-deficient skin, and provides a foundation for next-generation regenerative therapies.

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Comment on 'Incidence and Mortality of Mucous Membrane Pemphigoid in France'.

Ghanim D, Ghebrial M, Ansari Z … +4 more , Tognaccini C, Gupta K, Thomas LE, Wu JJ

Br J Dermatol · 2026 Jun · PMID 42261683 · Publisher ↗

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The US-UK pharmaceutical deal - do dermatologists have skin in the game?

Yiu ZZN, Wilson ECF

Br J Dermatol · 2026 Jun · PMID 42252504 · Publisher ↗

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Melanoma diagnosis during COVID-19: delay, disruption and the question of overdiagnosis.

Boada A, Tejera-Vaquerizo A

Br J Dermatol · 2026 Jun · PMID 42251709 · Publisher ↗

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