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Oncology Nursing Forum[JOURNAL]

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Caregiver Burden and Workplace Productivity Among Hospice Cancer Caregivers.

Thomas Hebdon MC, Xu J, Beck AC … +6 more , Cloyes KG, Mooney K, Reblin M, Lyn Tay D, Cleary C, Ellington L

Oncol Nurs Forum · 2023 Aug · PMID 37677767 · Full text

OBJECTIVES: To examine the relationships among family caregiver burden and workplace productivity and activity impairment among home hospice family caregivers of individuals with cancer who worked while providing end-of-... OBJECTIVES: To examine the relationships among family caregiver burden and workplace productivity and activity impairment among home hospice family caregivers of individuals with cancer who worked while providing end-of-life caregiving. SAMPLE & SETTING: Baseline data from a longitudinal study of communication between hospice providers and hospice family caregivers were used for this secondary analysis. METHODS & VARIABLES: Working family caregivers with complete workplace productivity and activity impairment data were included in this analysis (N = 30). Demographic data, caregiver burden, and workplace productivity and activity impairment were examined with descriptive statistics, correlation analysis, and hierarchical linear regressions. RESULTS: Hospice family caregivers were primarily White, female, married, and employed full-time. Caregiver burden levels were significantly positively associated with activity impairment, presenteeism, and work productivity loss. These relationships remained statistically significant when controlling for age. IMPLICATIONS FOR NURSING: Hospice and oncology nurses can support working hospice family caregivers by assessing for burden and associated workplace challenges, as well as by providing referrals for respite and community resources.

Risk Factors for a Higher Symptom Burden in Patients With Cancer During the COVID-19 Pandemic.

Hun Kwak J, Mackin LA, Block A … +14 more , Paul SM, Cooper BA, Abbott M, Chang SM, Hammer MJ, Kober KM, Levine JD, Pozzar R, Rhoads KF, Snowberg KE, Tsai KK, Van Blarigan EL, Van Loon K, Miaskowski C

Oncol Nurs Forum · 2023 Aug · PMID 37677766 · Publisher ↗

OBJECTIVES: To evaluate for subgroups of patients with distinct symptom profiles and differences in demographic and clinical characteristics and stress and resilience among these subgroups. SAMPLE & SETTING: 1,145 pa... OBJECTIVES: To evaluate for subgroups of patients with distinct symptom profiles and differences in demographic and clinical characteristics and stress and resilience among these subgroups. SAMPLE & SETTING: 1,145 patients with cancer aged 18 years or older completed a survey online. Data were collected between May 2020 and February 2021. METHODS & VARIABLES: Patients completed measures for depression, state anxiety, cognitive function, morning fatigue, evening fatigue, morning energy, evening energy, sleep disturbance, pain, stress, and resilience. Latent class profile analysis was used to identify subgroups of patients with distinct symptom profiles. Differences among the subgroups on study measures were evaluated using parametric and nonparametric tests. RESULTS: Four distinct profiles were identified (none, low, high, and very high). Patients in the high and very high classes reported clinically meaningful levels of all nine symptoms. Differences among the four profiles for stress and resilience exhibited a dose-response effect. IMPLICATIONS FOR NURSING: Findings can serve as benchmark data of the symptom burden of patients with cancer following the COVID-19 pandemic.

Changes in Health-Related Quality of Life During Multiple Myeloma Treatment: A Qualitative Interview Study.

Sonsby L, Rahbæk Dueholm J, Danbjørg DB … +2 more , Abildgaard N, Kongsgaard Nielsen L

Oncol Nurs Forum · 2023 Aug · PMID 37677765 · Publisher ↗

PURPOSE: To explore whether patients with multiple myeloma changed their construct of health-related quality of life during treatment. PARTICIPANTS & SETTING: 14 participants were selected from 10 hematology-oncology... PURPOSE: To explore whether patients with multiple myeloma changed their construct of health-related quality of life during treatment. PARTICIPANTS & SETTING: 14 participants were selected from 10 hematology-oncology departments in Denmark. METHODOLOGIC APPROACH: This interview study used a prospective, longitudinal, exploratory design. Semistructured interviews were conducted while participants were undergoing active treatment for multiple myeloma and six months after the baseline interview. Interviews were analyzed using systematic text condensation. FINDINGS: The overall theme at baseline was insecurity, and the overall theme at six months was coping. The following subthemes were also identified based on participants' description of their health-related quality of life: concerns about having a meaningful life, dealing with everyday limitations, and maintaining social networks; adjusting expectations to abilities; expanding social networks; and exploring a meaningful life. IMPLICATIONS FOR NURSING: Patients' ability to use coping strategies should be considered when screening for rehabilitation needs. During systematic in-depth symptom screening, unmet rehabilitation needs (e.g., physical functioning, fatigue, pain) may become apparent.

Exploring the Relationship Between Health-Illness Transition Experiences and Distress Among Patients With Pancreatic Cancer.

Goldberg JI, Flynn JR, Baser RE … +3 more , Nelson JE, Capezuti E, Schulman-Green D

Oncol Nurs Forum · 2023 Aug · PMID 37677764 · Full text

OBJECTIVES: To explore the correlation between health-illness transition (HIT) experiences and distress among patients with pancreatic cancer. SAMPLE & SETTING: 55 patients with a diagnosis of pancreatic cancer recei... OBJECTIVES: To explore the correlation between health-illness transition (HIT) experiences and distress among patients with pancreatic cancer. SAMPLE & SETTING: 55 patients with a diagnosis of pancreatic cancer receiving chemotherapy at a tertiary cancer center in New York. METHODS & VARIABLES: A prospective correlational study was performed to explore the frequency, extent, and management of HITs. HITs were evaluated using the Measurement of Transitions in Cancer Scale, and distress was measured with the National Comprehensive Cancer Network Distress Thermometer. RESULTS: All patients experienced at least one HIT. The extent of HITs decreased over time. Patients reported that they managed HITs moderately well. There was a significant correlation between unmanaged HITs and distress. As distress increased, the extent of the physical and emotional HITs increased and management worsened. IMPLICATIONS FOR NURSING: HITs are ubiquitous among patients diagnosed with pancreatic cancer. Associated distress inhibits management. Nurses are well suited to assess for potential HITs and to support self-management of HITs.

Women's Health Beliefs and Intention to Use Chemoprevention for Breast Cancer.

Keller KG, Toriola AT, Kraenzle Schneider J

Oncol Nurs Forum · 2023 Aug · PMID 37677763 · Publisher ↗

OBJECTIVES: To investigate the associations between women's health beliefs and their intention to use chemoprevention. SAMPLE & SETTING: Participants were postmenopausal women (N = 400) aged 50-64 years who were recr... OBJECTIVES: To investigate the associations between women's health beliefs and their intention to use chemoprevention. SAMPLE & SETTING: Participants were postmenopausal women (N = 400) aged 50-64 years who were recruited for a study on mammographic breast density. METHODS & VARIABLES: Participants completed a screening mammogram and breast cancer health belief questionnaires. The authors regressed intention to use chemoprevention onto health belief scores (breast cancer fatalism, fear, perceived threat, perceived benefits, barriers, and self-efficacy). RESULTS: Nearly half of the participants indicated that they would be interested in using chemoprevention if they were found to be at high risk for developing breast cancer. Women who reported higher perceived benefits of chemoprevention, higher perceptions of their ability to use chemoprevention (self-efficacy), and fewer logistic barriers to seeking health care had significantly higher intention to use chemoprevention. IMPLICATIONS FOR NURSING: Interventions aimed at reducing logistic barriers to health care may increase the uptake of chemoprevention among at-risk women. In addition, women at the time of mammography and women with higher levels of education may be motivated to consider using chemoprevention.

The Effect of Acceptance and Commitment Therapy-Based Psychoeducation on Body Image, Quality of Sexual Life, and Dyadic Adjustment of Women After Breast Cancer Surgery.

Tunç E, Sevcan Orak O, İşeri Ö

Oncol Nurs Forum · 2023 Aug · PMID 37677762 · Publisher ↗

OBJECTIVES: To determine the effect of acceptance and commitment therapy-based psychoeducation applied to women who have undergone breast cancer surgery on body image, quality of sexual life, and dyadic adjustment. SAMPL... OBJECTIVES: To determine the effect of acceptance and commitment therapy-based psychoeducation applied to women who have undergone breast cancer surgery on body image, quality of sexual life, and dyadic adjustment. SAMPLE &AMP; SETTING: Women who have undergone breast cancer surgery were included. The research had a single-group quasi-experimental design with pre-/post-test measurements and 31 participants. METHODS &AMP; VARIABLES: The research was carried out between February and July 2021. Data were collected using a personal information form, a body image perception scale, the Dyadic Adjustment Scale, and the Sexual Quality of Life-Female. RESULTS: The post-test mean scores of body image, quality of sexual life, and dyadic adjustment scales were significantly higher than pretest (p < 0.05). IMPLICATIONS FOR NURSING: To improve the body image, quality of sexual life, and dyadic adjustment of women who have undergone breast cancer surgery, nurses are recommended to include psychoeducation based on acceptance and commitment therapy interventions in the nursing care process and to evaluate the effectiveness.

The Formation of Stigma and Its Social Consequences on Chinese People Living With Lung Cancer: A Qualitative Study.

Liu X, Zhong J, Ren J … +1 more , Zhang JE

Oncol Nurs Forum · 2023 Aug · PMID 37677761 · Publisher ↗

PURPOSE: To explore the formation of stigma toward lung cancer and its social consequences for Chinese patients living with this diagnosis. PARTICIPANTS &AMP; SETTING: A purposive sample of 19 patients with lung cancer w... PURPOSE: To explore the formation of stigma toward lung cancer and its social consequences for Chinese patients living with this diagnosis. PARTICIPANTS &AMP; SETTING: A purposive sample of 19 patients with lung cancer were recruited in the outpatient clinic of a tertiary cancer center in southern China. METHODOLOGIC APPROACH: This is a descriptive qualitative study. Semistructured interviews were conducted to explore the formation of stigma toward lung cancer and its social consequences. Audio recordings were transcribed verbatim and coded by the thematic analysis approach. FINDINGS: The following three themes emerged from interviews: (a) sources of stigma, (b) stigma manifestations, and (c) social consequences of stigma. IMPLICATIONS FOR NURSING: Considering that the formation of lung cancer stigma is socioculturally specific, existing stereotypes and prejudice in Chinese society should be the focus of antistigma interventions at the population level. At the individual level, cancer concealment, resistance to cancer identity, and feelings of no longer being a normal person were three common manifestations that may be indicators for stigma screening among people with lung cancer. In addition, stigmas profoundly affected patients' social lives and their help-seeking behaviors, and medical staff should use effective strategies to alleviate stigma toward lung cancer and its effects.

Advances in Treatment and Health-Related Quality of Life: A Cohort Study of Older Adult Survivors of Breast Cancer.

Burrell SA, Sasso GE, MacKenzie Greenle M

Oncol Nurs Forum · 2023 Aug · PMID 37677760 · Publisher ↗

OBJECTIVES: To determine whether there are differences in the health-related quality of life (HRQOL) of older adult survivors of breast cancer (BC) diagnosed in different time periods and to gain insight into whether adv... OBJECTIVES: To determine whether there are differences in the health-related quality of life (HRQOL) of older adult survivors of breast cancer (BC) diagnosed in different time periods and to gain insight into whether advances in BC treatment have improved HRQOL. SAMPLE &AMP; SETTING: Three cohorts of older adult survivors of BC diagnosed before 1995, from 1996 to 2005, and from 2006 to 2015 were examined using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linked databases. METHODS &AMP; VARIABLES: HRQOL was measured using the Veterans RAND 12-Item Health Survey. Mean cohort HRQOL scores were compared using analysis of variance, then multivariate regression models were used to examine the effects of cohort membership and covariates on mental and physical HRQOL. RESULTS: Adjusted mean HRQOL scores trended significantly lower with each successive cohort. Higher comorbidity count and increased functional limitations were negatively associated with HRQOL, and income, education level, and better general health perceptions were positively associated with HRQOL. IMPLICATIONS FOR NURSING: Regardless of time since diagnosis, older survivors of BC are at risk for poor HRQOL and should be regularly assessed. Maximizing HRQOL requires consideration of the survivor's resources, comorbidities, and functional limitations when planning care.

Empowering Lung Cancer Survivors in Post-Treatment Survivorship Care Using Participatory Action Research.

Filchner K, Zoucha R, Lockhart JS … +1 more , Denlinger CS

Oncol Nurs Forum · 2023 Aug · PMID 37677759 · Publisher ↗

PURPOSE: To explore the experiences of lung cancer survivors (LCSs) and their informal and professional caregivers with post-treatment care and to empower them to implement action-based study findings. PARTICIPANTS &AMP;... PURPOSE: To explore the experiences of lung cancer survivors (LCSs) and their informal and professional caregivers with post-treatment care and to empower them to implement action-based study findings. PARTICIPANTS &AMP; SETTING: Participants were recruited using purposeful and snowball sampling from patients at a National Cancer Institute-designated cancer center in the northeastern United States. METHODOLOGIC APPROACH: This study used a participatory action research (PAR) four-phase design. Phase 1 was a focused ethnography; phase 2 consisted of a core group of participants deciding on an action, which was implemented in phase 3; and phase 4 consisted of an evaluation of the action. FINDINGS: The study found 28 categories, eight patterns, and three themes. The themes were the need for resources and education, involvement in mentoring and advocacy, and the value of living versus surviving. The action was creating two flyers focused on resources and advocacy for post-treatment support for LCSs. All participants agreed with the themes and action. Tobacco management and smoking-related stigma for LCSs were the only topics of dissent. IMPLICATIONS FOR NURSING: Oncology nurses can use PAR to empower survivors in their post-treatment care. Future PAR cycles should focus on creating support groups and alleviating stigma for LCSs and their caregivers.

Finding the Optimal Exercise Dose While Living With Cancer-Related Fatigue: A Qualitative Study.

Wechsler S, Fu MR, Wood Magee L … +1 more , Lyons KD

Oncol Nurs Forum · 2023 Aug · PMID 37677758 · Publisher ↗

PURPOSE: To gain insight into how survivors of breast cancer (SBCs) with cancer-related fatigue (CRF) self-monitor and manage exercise dose in the context of daily life, and how they identify an optimal exercise dose. PA... PURPOSE: To gain insight into how survivors of breast cancer (SBCs) with cancer-related fatigue (CRF) self-monitor and manage exercise dose in the context of daily life, and how they identify an optimal exercise dose. PARTICIPANTS &AMP; SETTING: 11 SBCs with CRF who reported weekly exercise were recruited from a breast cancer center at a large urban hospital in the northeastern region of the United States. METHODOLOGIC APPROACH: One-on-one semistructured interviews were conducted using a descriptive phenomenologic method. Inductive data analysis was performed within and across cases. FINDINGS: The following themes emerged: examining the impact of exercise, finding an optimal dose, and remaining flexible to sustain exercise. Participants used trial and error to explore exercise dose, examining the effects of varying doses on daily life. These effects had behavioral implications and resulted in a nonlinear process and the perception that an optimal exercise dose is dynamic within the context of daily life. IMPLICATIONS FOR NURSING: Strategies to support SBCs with CRF to efficiently achieve optimal exercise doses with fewer setbacks may improve individuals' ability to self-manage and mitigate CRF. This study's findings provide practical approaches for nurses to encourage the initiation and adoption of exercise behaviors after treatment for breast cancer.

Next-Generation Symptom Science in Oncology Nursing.

Lyon D

Oncol Nurs Forum · 2023 Jun · PMID 37677755 · Publisher ↗

The 2023 Oncology Nursing Society (ONS) Congress® was outstanding. More than 3,000 attendees gathered to focus on oncology nursing in San Antonio, Texas. The timing of ONS Congress coincided with Fiesta, the annual festi... The 2023 Oncology Nursing Society (ONS) Congress® was outstanding. More than 3,000 attendees gathered to focus on oncology nursing in San Antonio, Texas. The timing of ONS Congress coincided with Fiesta, the annual festival.

Effects of Physical Exercise Interventions for Individuals With Gynecologic Cancer: A Systematic Review and Meta-Analysis.

Ma RC, Li XJ, Liu R … +1 more , Xu XX

Oncol Nurs Forum · 2023 Jun · PMID 37677754 · Publisher ↗

PROBLEM IDENTIFICATION: Data on the efficacy of physical exercise interventions for individuals with gynecologic cancer are limited and discordant. The purpose of this review was to determine the benefits of exercise int... PROBLEM IDENTIFICATION: Data on the efficacy of physical exercise interventions for individuals with gynecologic cancer are limited and discordant. The purpose of this review was to determine the benefits of exercise interventions in this population. LITERATURE SEARCH: The PubMed®, Web of Science, Embase® (Ovid), and Cochrane Central Register of Controlled Trials databases were searched for studies published from January 1, 2010, to November 9, 2022. DATA EVALUATION: 12 randomized controlled trials were included. A quantitative synthesis method was used to investigate the effects of exercise interventions on individuals with gynecologic cancer. SYNTHESIS: The findings indicate that physical exercise interventions may have beneficial effects on the fatigue, depression, and health-related quality of life of this patient population. However, because of the small group of studies available, the evidence must be regarded as preliminary. IMPLICATIONS FOR PRACTICE: Clinicians and oncology nurses should recommend and refer individuals with gynecologic cancer to clinic- or community-based physical exercise programs.

Understanding mHealth Patient-Reported Priority Symptoms for Gynecologic Cancer During Chemotherapy: A Secondary Analysis.

Wilson CM, Iacob E, Mooney K

Oncol Nurs Forum · 2023 Jun · PMID 37677753 · Publisher ↗

OBJECTIVES: To determine the percentage of and the most prevalent moderate to severe symptoms and to analyze longitudinal patterns and co-occurrence of symptoms during the first three cycles of chemotherapy. SAMPLE &AMP;... OBJECTIVES: To determine the percentage of and the most prevalent moderate to severe symptoms and to analyze longitudinal patterns and co-occurrence of symptoms during the first three cycles of chemotherapy. SAMPLE &AMP; SETTING: A secondary analysis of 26 women with gynecologic cancer who reported daily symptoms. METHODS &AMP; VARIABLES: Moderate to severe symptom presence and severity levels were calculated as proportions. Symptoms for each patient were graphed during three cycles and analyzed for patterns of onset, duration, and clustering. RESULTS: Patients completed 1,562 calls to the remote symptom monitoring system. The most commonly reported moderate to severe symptoms were pain, fatigue, and trouble sleeping. Pain and fatigue co-occurred with trouble sleeping in one symptom pattern. Patterns included no moderate to severe symptoms, moderate to severe symptoms during one cycle, moderate to severe symptoms during two cycles, and moderate to severe symptoms during all cycles. IMPLICATIONS FOR NURSING: Nurses should consistently assess symptoms across cycles. To verify distinct classes of symptoms and better target interventions, further study is warranted.

The Effects of Pranayama or Deep Breathing Exercises on Fatigue and Sleep Quality in Women Receiving Radiation Therapy for Breast Cancer.

Gündogdu F, Koçaşlı S

Oncol Nurs Forum · 2023 Jun · PMID 37677752 · Publisher ↗

OBJECTIVES: To evaluate the effects of pranayama and deep breathing exercises on fatigue and sleep quality in women undergoing radiation therapy for breast cancer. SAMPLE &AMP; SETTING: This randomized controlled study w... OBJECTIVES: To evaluate the effects of pranayama and deep breathing exercises on fatigue and sleep quality in women undergoing radiation therapy for breast cancer. SAMPLE &AMP; SETTING: This randomized controlled study was conducted on the outpatient radiation oncology unit of a hospital with 20 patients each in pranayama, deep breathing, and standard care groups (N = 60). METHODS &AMP; VARIABLES: The Piper Fatigue Scale and the Pittsburgh Sleep Quality Index were used to evaluate the participants' fatigue and sleep quality. RESULTS: The control group showed a significant increase in fatigue levels at the end of radiation therapy compared to the beginning. Sleep quality was improved only in the pranayama group. IMPLICATIONS FOR NURSING: Pranayama can be learned easily, can be performed anywhere, and does not require any equipment, making it a convenient exercise for patients. Oncology nurses can take the lead in suggesting pranayama for symptom management.

The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy.

Jeong An H, Kang SJ

Oncol Nurs Forum · 2023 Jun · PMID 37677751 · Publisher ↗

OBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy. SAMPLE &AMP; SETTING: A descriptive correlational study was... OBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy. SAMPLE &AMP; SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey. METHODS &AMP; VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life. RESULTS: More than half of the participants experienced severe TSAs. The longest-lasting taste after the start of chemotherapy was a bitter taste, and participants experienced it more strongly after starting chemotherapy than before. The more severe the TSAs, the lower the overall quality of life, particularly physical well-being and functional well-being. IMPLICATIONS FOR NURSING: Nurses should be vigilant about whether people with cancer receiving chemotherapy are experiencing TSAs. It is recommended to educate women in this population about avoiding bitter foods and foods with strong smells. Providing information about TSAs before treatment can help people with cancer cope.

Rebuilding and Guiding the Self With Spirituality: A Grounded Theory of Experiences of Adolescents and Young Adults With Cancer.

Gürsu O, Gürcan M, Turan S

Oncol Nurs Forum · 2023 Jun · PMID 37677750 · Publisher ↗

PURPOSE: To clarify the experiences of spirituality among adolescents and young adults (AYAs) with cancer following diagnosis. PARTICIPANTS &AMP; SETTING: Participants were recruited at a clinic and on an oncology unit i... PURPOSE: To clarify the experiences of spirituality among adolescents and young adults (AYAs) with cancer following diagnosis. PARTICIPANTS &AMP; SETTING: Participants were recruited at a clinic and on an oncology unit in Turkey. A combination of purposive sampling and theoretical sampling strategy was used to identify 14 participants. METHODOLOGIC APPROACH: A grounded theory design was used for this study. Semistructured interviews were conducted with each participant between October 2021 and January 2022. The data were analyzed using open, axial, and selective coding. FINDINGS: All the participants were Muslim, were aged 15-39 years, spoke Turkish, and had undergone treatment for any type of cancer. The core category was identified as rebuilding and guiding the self with spirituality. AYAs connected more closely with their sense of spirituality after being diagnosed with cancer. IMPLICATIONS FOR NURSING: This study demonstrated the importance of providing a supportive healing environment to address the spiritual dimension of the cancer experience for AYAs. Individualized interventions ensuring an appropriate level of spiritual care based on clinical standards are essential to meet the needs of patients and ensure positive long-term health outcomes.

Symptom Clusters in Patients With Colorectal Cancer and Diabetes Over Time.

Storey S, Luo X, Ren J … +2 more , Huang K, Von Ah D

Oncol Nurs Forum · 2023 Jun · PMID 37677749 · Publisher ↗

OBJECTIVES: To examine symptoms and symptom clusters in patients with colorectal cancer (CRC) with or without diabetes at three key periods (0-6 months, 12-18 months, and 24-30 months) post-initial chemotherapy. SAMPLE &... OBJECTIVES: To examine symptoms and symptom clusters in patients with colorectal cancer (CRC) with or without diabetes at three key periods (0-6 months, 12-18 months, and 24-30 months) post-initial chemotherapy. SAMPLE &AMP; SETTING: Patients with CRC from a cancer center in the midwestern United States between January 2007 and December 2017. METHODS &AMP; VARIABLES: Eight of the most common symptoms (fatigue, gastrointestinal issues, depression, anxiety, peripheral neuropathy, physical function, cognition, and sleep disturbance) reported by patients with CRC and patients with diabetes were extracted from electronic health records. Exploratory factor analysis was used to identify symptom clusters, which were assessed for patterns and clinical relevance. RESULTS: Gastrointestinal issues and fatigue were the most prevalent symptoms in patients with CRC at each period. Across the three periods, patients with CRC and diabetes had more symptom clusters (n = 7) compared to patients with CRC without diabetes (n = 4). No stable symptom clusters were identified for either group. IMPLICATIONS FOR NURSING: Oncology clinicians must recognize that patients with CRC and diabetes may present with exacerbated symptoms or symptom clusters. Ongoing assessment and monitoring of patients with CRC and diabetes for symptoms and symptom clusters is important because they may be at an increased risk for higher symptom burden.

Higher Levels of Stress and Neuropsychological Symptoms Are Associated With a High Nausea Profile in Patients With Cancer Receiving Chemotherapy.

Singh KP, Cooper BA, Tofthagen CS … +9 more , Fryer JD, Singh P, Pituch K, Zhu Q, Gu H, Hammer MJ, Conley YP, Levine JD, Miaskowski C

Oncol Nurs Forum · 2023 Jun · PMID 37677748 · Publisher ↗

OBJECTIVES: To evaluate differences in the severity of global, cancer-specific, and cumulative life stress, resilience, and common neuropsychological symptoms among four subgroups of patients with distinct chemotherapy-i... OBJECTIVES: To evaluate differences in the severity of global, cancer-specific, and cumulative life stress, resilience, and common neuropsychological symptoms among four subgroups of patients with distinct chemotherapy-induced nausea (CIN) profiles. SAMPLE &AMP; SETTING: Adult patients with cancer (N = 1,343) receiving chemotherapy. METHODS &AMP; VARIABLES: Patients completed stress, resilience, and neuropsychological symptom severity measures. The Memorial Symptom Assessment Scale was used to assess CIN occurrence six times over two cycles of chemotherapy. Parametric and nonparametric statistics were used to evaluate differences among subgroups of patients with distinct CIN profiles. RESULTS: The high class had significantly higher levels of global, cancer-specific, and cumulative life stress; significantly higher levels of depression, anxiety, sleep disturbance, morning and evening fatigue, and pain; and lower levels of morning and evening energy and cognitive dysfunction. IMPLICATIONS FOR NURSING: Clinicians need to evaluate CIN occurrence across each cycle of chemotherapy and assess patients for various types of stress and common neuropsychological symptoms.

Impact of Race and Area Deprivation on Triple-Negative Metastatic Breast Cancer Outcomes.

Rosenzweig MQ, Nugent B, McGuire M

Oncol Nurs Forum · 2023 Jun · PMID 37677747 · Publisher ↗

OBJECTIVES: To describe area deprivation, anxiety, depression, relative dose intensity of first-line metastatic breast cancer (MBC) treatment, and survival in Black and White women who had died from triple-negative MBC,... OBJECTIVES: To describe area deprivation, anxiety, depression, relative dose intensity of first-line metastatic breast cancer (MBC) treatment, and survival in Black and White women who had died from triple-negative MBC, including interaction analysis. SAMPLE &AMP; SETTING: This cohort study drew from a database of women who had died from MBC (N = 53). METHODS &AMP; VARIABLES: Descriptive statistics, independent t tests, analysis of variance, and Mann-Whitney U tests were used, and effect sizes were calculated. RESULTS: Compared with White women, Black women reported higher anxiety and depression at MBC baseline. Black women living in areas of higher deprivation experienced shorter overall survival than White women living in similar areas (9.9 months versus 24.6 months). These results were not statistically significant, likely because of a small sample size, but were clinically meaningful. IMPLICATIONS FOR NURSING: Black and low-income women with breast cancer experience inferior survival as compared with White and higher-income women. Newer explanatory models for racial disparity in cancer outcomes include the assessment of neighborhood deprivation. White women may be less affected by their neighborhood, even when living in areas of greater deprivation influencing cancer outcomes. This merits further exploration.

Familiarity and Perceptions of Ovarian Cancer Biomarker Testing and Targeted Therapy: A Survey of Oncology Nurses in the United States.

Weimer J, Bozorghadad H, Schoonover K … +2 more , Carll C, Repco K

Oncol Nurs Forum · 2023 Jun · PMID 37677746 · Publisher ↗

OBJECTIVES: To assess oncology nurses' awareness of biomarker testing and targeted therapy for ovarian cancer. SAMPLE &AMP; SETTING: 100 oncology nurses completed an online survey in June 2022. METHODS &AMP; VARIABLES: A... OBJECTIVES: To assess oncology nurses' awareness of biomarker testing and targeted therapy for ovarian cancer. SAMPLE &AMP; SETTING: 100 oncology nurses completed an online survey in June 2022. METHODS &AMP; VARIABLES: A cross-sectional survey was used to examine nurses' understanding of ovarian cancer testing and treatments, assess barriers, and identify opportunities for further education. RESULTS: Almost all respondents believed biomarker testing and targeted therapy were very/extremely important in diagnosing and supporting treatment of patients with ovarian cancer. Nurses were very/extremely familiar with cancer antigen 125 and germline testing, but fewer reported the same familiarity with somatic testing. Most nurses were familiar with targeted therapy for ovarian cancer, but only about half were very/extremely familiar with poly(ADP-ribose) polymerase (PARP) inhibitors. Less than half felt highly knowledgeable about PARP inhibitors. IMPLICATIONS FOR NURSING: It is important that oncology nurses understand biomarker testing and targeted therapy. There is an opportunity to provide resources to nurses to help them become more comfortable with PARP inhibitors in particular.
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