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Indian Journal Of Pediatrics[JOURNAL]

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Development of a Simple Clinical Risk Score for Mortality Prediction in Neonatal Gram-Negative Sepsis.

Verma A, Sinha R, Periwal S … +4 more , Mishra P, Anbarasan A, Naranje K, Singh A

Indian J Pediatr · 2026 Jul · PMID 42176111 · Publisher ↗

OBJECTIVES: To identify clinical and laboratory predictors of mortality and develop a simple bedside risk score for neonates with Gram-negative sepsis. METHODS: A total of 50 neonates satisfying as per the inclusion crit... OBJECTIVES: To identify clinical and laboratory predictors of mortality and develop a simple bedside risk score for neonates with Gram-negative sepsis. METHODS: A total of 50 neonates satisfying as per the inclusion criteria during the reference period were included in the study. Independent predictors of mortality were identified using univariable and multivariable binary logistic regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression, and were used to develop a Neonatal Risk Scoring System (NRSS). RESULTS: Mortality occurred in 38% (19/50). On multivariable analysis, necrotizing enterocolitis (NEC) ≥ Stage II (OR 45.24, p = 0.003), refractory shock (OR 6.54, p = 0.047), and leukopenia (OR 20.01, p = 0.018) independently predicted mortality. The NRSS (weights 8, 4, and 6, respectively) showed excellent discrimination (AUC > 0.9). Mean NRSS was higher in non-survivors (9.47 ± 5.37) vs. survivors (1.74 ± 2.35, p < 0.001). A cut-off ≥ 7 predicted mortality with 73.7% sensitivity and 96.8% specificity. CONCLUSIONS: NEC ≥ Stage II, refractory shock, and leukopenia independently predict mortality. The NRSS provides a simple, reliable tool for early risk stratification.
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Hypoglossal Nerve Palsy During Kawasaki Disease.

Missaire J, Merlin E

Indian J Pediatr · 2026 Jul · PMID 42176110 · Publisher ↗

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Diagnostic Challenges in High-Functioning Autism: A Case of Misdiagnosed Psychiatric Disorder.

Vikram A, Arumugam A, Nithya M

Indian J Pediatr · 2026 Jul · PMID 42176109 · Publisher ↗

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Normal Saline Versus Ringer's Lactate for Intravenous Fluid Therapy in Children with Diabetic Ketoacidosis: A Randomized Controlled Trial - Authors' Reply.

Gupta S, Singhal D, Kumar V

Indian J Pediatr · 2026 Jul · PMID 42171946 · Publisher ↗

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Asymmetric Trilaminar Sign in a Child with Severe Cytokine Storm Due to Dengue-Associated Acute Necrotizing Encephalopathy of Childhood: Author's Reply.

Bhanudeep S

Indian J Pediatr · 2026 Jul · PMID 42171945 · Publisher ↗

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Wide Complex Tachyarrhythmia - Be Careful before Labelling: A Case of Supraventricular Tachycardia with Aberrancy.

Venkatesan DK, Ginigeri C, Arigela K … +2 more , Ali SMN, Krishnappa D

Indian J Pediatr · 2026 Jun · PMID 42168493 · Publisher ↗

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Fascioliasis Presenting with Eosinophilia, Gastrointestinal Bleed and Biliary Obstruction.

Kumari J, Dash N, Bhujade H … +4 more , Thunga C, Verma S, Bhatia A, Lal SB

Indian J Pediatr · 2026 Jun · PMID 42159661 · Publisher ↗

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Protocolized vs. Conventional Sedation Among Mechanically Ventilated Children in a Pediatric Intensive Care Unit - A Pre-Post Study: Authors' Reply.

Chidambaram M, Parameswaran N

Indian J Pediatr · 2026 Jun · PMID 42159660 · Publisher ↗

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Prediabetes in Indian Adolescents: A Window for Intervention.

Nanda PM, Yadav J

Indian J Pediatr · 2026 Jul · PMID 42154160 · Publisher ↗

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Oral Melatonin Supplementation for Sleep Disturbances in Children with Cerebral Palsy: A Randomized Double-Blind Controlled Trial - Authors' Reply.

Mundada S, Zambani J

Indian J Pediatr · 2026 Jul · PMID 42154159 · Publisher ↗

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Risk Factors for False-Positive Ultrasound in Pediatric Acute Appendicitis: A Prospective Cohort Study - Correspondence.

Jiang W

Indian J Pediatr · 2026 Jul · PMID 42154158 · Publisher ↗

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Inflammatory Myofibroblastic Tumor of the Gallbladder with IgG4-Positive Plasma Cell Infiltration.

Zhao A, Huo B, Luo X

Indian J Pediatr · 2026 Jul · PMID 42154157 · Publisher ↗

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Neurotuberculosis Presenting as Acute Flaccid Paralysis.

Gaddigoudar M, Gupta R, Khera R … +1 more , Wander A

Indian J Pediatr · 2026 Jul · PMID 42154156 · Publisher ↗

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Dilated Cardiomyopathy with Ectodermal Features Due to Homozygous PPP1R13L Variant.

Acharya R, Bhalla K, Agarwal K

Indian J Pediatr · 2026 Jul · PMID 42154155 · Publisher ↗

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Perforated Subhepatic Appendicitis Presenting as a Large Intrahepatic Abscess: CT-Based Diagnosis and Successful Conservative Management.

Bharti A, Singh R, Ahluwalia S

Indian J Pediatr · 2026 Jul · PMID 42154154 · Publisher ↗

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Immune Mediated Cognitive Dysfunction Following Japanese Encephalitis.

Veeraraghavan V, Ghosh S, Das A … +2 more , Kaman S, Kaushik JS

Indian J Pediatr · 2026 Jul · PMID 42154153 · Publisher ↗

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Extreme Hyperbilirubinemia with Hepatitis - A Infection in a Child with Sickle Cell Trait.

Ansari E, Das S, Tripathy SK

Indian J Pediatr · 2026 Jul · PMID 42154152 · Publisher ↗

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A Prospective Model for Detecting Missed Appendicitis in Low-Risk Pediatric Patients.

Zouari M, Belhajmansour M, Laadhar M … +5 more , Tounsi MK, Hbaieb M, Jarboui O, Dhaou MB, Mhiri R

Indian J Pediatr · 2026 Jul · PMID 42149353 · Publisher ↗

OBJECTIVES: To identify predictors of true appendicitis among children with a Pediatric Appendicitis Score (PAS) <4 and to develop a model for detecting missed appendicitis in this low-risk population. METHODS: A prospec... OBJECTIVES: To identify predictors of true appendicitis among children with a Pediatric Appendicitis Score (PAS) <4 and to develop a model for detecting missed appendicitis in this low-risk population. METHODS: A prospective study including consecutive children aged 2-14 y presenting with suspected appendicitis was conducted between January 2022 and October 2025. Only children with PAS <4 were included in the analysis. RESULTS: Among 1174 children evaluated, 404 (34.4%) had PAS <4 and were included. Of these, 39 (9.6%) had confirmed appendicitis. The mean age of this cohort was 9.8 ± 2.6 y, and males accounted for 48.5% of the population. Compared with non-appendicitis cases, affected children had higher rates of vomiting (61.5% vs. 40.3%, p = 0.011), higher median WBC counts (8.8 vs. 7.7 × 10⁹/L, p = 0.001), and higher CRP levels (17 vs. 5 mg/L, p = 0.001). On multivariable analysis, WBC >8.8 × 10⁹/L (OR 2.77; p = 0.012), CRP ≥10 mg/L (OR 3.17; p = 0.005), and positive ultrasound (OR 17.36; p <0.001) were independent predictors. Ultrasound showed the highest diagnostic accuracy (85%) and negative predictive value (97%). CONCLUSIONS: Nearly 10% of children with PAS <4 had confirmed appendicitis. Combining inflammatory markers with targeted ultrasound may improve early detection of missed appendicitis in low-risk pediatric patients.
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Normal Saline Versus Ringer's Lactate for Intravenous Fluid Therapy in Children with Diabetic Ketoacidosis: A Randomized Controlled Trial - Correspondence.

Jiang W, Wang T, Bai C

Indian J Pediatr · 2026 Jul · PMID 42149352 · Publisher ↗

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Inhaled Corticosteroids Plus Tiotropium Compared to Inhaled Corticosteroids Plus Montelukast in Children with Partly Controlled/Uncontrolled Asthma: A Non-Inferiority Trial - Authors' Reply.

Sengupta S, Kumar K, Das RR

Indian J Pediatr · 2026 Jul · PMID 42141333 · Publisher ↗

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