Annals Of Internal Medicine[JOURNAL]

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Annals Graphic Medicine - If Care Came in Doses: A Family Caregiver's Perspective.

Ayeni BO

Ann Intern Med · 2026 Apr · PMID 41871355 · Publisher ↗

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Experts discuss developments in dementia.

Butterfield S

Ann Intern Med · 2026 May · PMID 41871354 · Publisher ↗

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Timing of Pegfilgrastim Administration and Pegfilgrastim-Induced Bone Pain : A Prospective, Randomized, Phase 3 Trial.

Li P, Chen Y, Lin Y … +15 more , Zhang X, Cheng M, Zhu T, Gao HF, Zhang L, Li J, Huang N, Chen Y, Liang M, Zhang Y, Huang S, Zheng J, Wu C, Yang C, Wang K

Ann Intern Med · 2026 May · PMID 41871353 · Publisher ↗

BACKGROUND: Pegfilgrastim-induced bone pain (PIBP) is common and lacks effective treatment. OBJECTIVE: To determine whether there is an association between the timing of pegfilgrastim administration and PIBP. DESIGN: Thr... BACKGROUND: Pegfilgrastim-induced bone pain (PIBP) is common and lacks effective treatment. OBJECTIVE: To determine whether there is an association between the timing of pegfilgrastim administration and PIBP. DESIGN: Three-arm randomized controlled trial. (ClinicalTrials.gov: NCT05841186). SETTING: A tertiary A-level hospital. PATIENTS: Patients with I to III stage breast cancer who were naive to chemotherapy. INTERVENTION: Patients were randomly allocated in a 1:1:1 ratio to the 24-hour, 48-hour, or 72-hour group based on the timing of pegfilgrastim administration postchemotherapy. MEASUREMENTS: The primary end point was the area under the curve (AUC) of the daily worst bone pain score (assessed using the "worst pain" question from the Brief Pain Inventory, a 0 to 10 numerical rating scale [NRS]) for 5 consecutive days in the first chemotherapy cycle. Secondary end points included the incidence of severe bone pain (>5 on the NRS), neutropenia, and febrile neutropenia (FN). RESULTS: The intention-to-treat analyses included 159 patients, with 53 in each group. For the first cycle, in the 72-hour group, the mean AUC exhibited a statistically significant reduction from 12.74 in the 24-hour group and 14.20 in the 48-hour group to 6.05 (all 0.001). Furthermore, the incidence of severe bone pain also declined significantly from 58.5% in the 24-hour group and 66.0% in the 48-hour group to 22.6% in the 72-hour group (all 0.001). There was no substantial difference in the incidence of neutropenia among groups, and no patients developed FN. LIMITATION: Open label, single center, and relatively small sample size. CONCLUSION: Administration of pegfilgrastim 72 hours postchemotherapy reduced PIBP compared with 24- and 48-hour administration and did not seem to be associated with higher rates of neutropenia or FN. PRIMARY FUNDING SOURCE: National Natural Science Foundation of China.

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Annals Video Summary - Prevention of Recurrent Nephrolithiasis in Adults and Children.

Ann Intern Med · 2026 May · PMID 41871352 · Publisher ↗

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Annals On Call - Managing Hyponatremia Part 1.

Centor RM, Topf JM

Ann Intern Med · 2026 Mar · PMID 41839056 · Publisher ↗

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Annals Consult Guys - Colonoscopy and Anticoagulation: A Challenging Combination.

Weitz HH, Merli GJ, Coben RM

Ann Intern Med · 2026 Mar · PMID 41839055 · Publisher ↗

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Annals for Educators - March 2026.

Laine C

Ann Intern Med · 2026 Mar · PMID 41839054 · Publisher ↗

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Behind the Seen: Searching for Peace in a House With Violence.

Acharya B

Ann Intern Med · 2026 Mar · PMID 41839053 · Publisher ↗

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The Problem of Suffering.

Allencherril J

Ann Intern Med · 2026 Mar · PMID 41839052 · Publisher ↗

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Reported Mammography Screening Interval by Age Among U.S. Women.

Aripoli A, Lee MV

Ann Intern Med · 2026 Mar · PMID 41839051 · Publisher ↗

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Reported Mammography Screening Interval by Age Among U.S. Women.

Dixit MN, Wolfson EA, Aliberti GM … +1 more , Schonberg MA

Ann Intern Med · 2026 Mar · PMID 41839050 · Publisher ↗

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Aware, Guided, and Grateful.

Hingle ST

Ann Intern Med · 2026 Mar · PMID 41839049 · Publisher ↗

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Correction: Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer.

Ann Intern Med · 2026 May · PMID 41839040 · Publisher ↗

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Dementia: Clinical Challenges.

Laine C, Turner BJ, Qaseem A … +1 more , Moyer DV

Ann Intern Med · 2026 May · PMID 41839039 · Publisher ↗

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The Importance of the Childhood Immunization Schedule for Internal Medicine.

Goldman JM, Mitchell KM, Hopkins RH

Ann Intern Med · 2026 Jun · PMID 41839038 · Publisher ↗

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Q&A: Looking at gun ownership after the pandemic.

Butterfield S

Ann Intern Med · 2026 May · PMID 41839037 · Publisher ↗

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Incentivizing Deprescribing for Health Care Quality Not Quantity.

Langford AV, Reeve E, Lin CC … +1 more , Qaseem A

Ann Intern Med · 2026 May · PMID 41839036 · Publisher ↗

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Firearm Acquisition and New Exposure to Household Firearms After the Initial Pandemic Purchasing Surge: Results From the 2024 National Firearms Survey.

Miller M, Fischer S, Azrael D

Ann Intern Med · 2026 May · PMID 41839035 · Publisher ↗

BACKGROUND: Firearm acquisitions in the United States surged after the onset of the pandemic. The increase, sustained through at least early 2021, resulted from a modest increase in the proportion of long-standing gun ow... BACKGROUND: Firearm acquisitions in the United States surged after the onset of the pandemic. The increase, sustained through at least early 2021, resulted from a modest increase in the proportion of long-standing gun owners who purchased firearms (most were White and men) and an unprecedented increase in the proportion of adults who became new gun owners (half were women; half were Hispanic and/or people of color). Little is known about firearm acquisitions beyond 2021. OBJECTIVE: To estimate the number of adults who acquired firearms since 1 January 2021, how many were new owners, and how many other people they newly exposed to household firearms. DESIGN: Probability-based national survey conducted 18 December to 25 December 2024. SETTING: United States. PARTICIPANTS: 4059 firearm owners. MEASUREMENTS: The number and characteristics of respondents who acquired firearms from 2021 to 2024, distinguishing those who already owned firearms from those who did not; among the latter, the number of household members newly exposed to firearms. RESULTS: An estimated 29.8 million adults (95% CI, 28.2 to 31.5 million) acquired firearms from 2021 to 2024; 11.2 million adults (CI, 10.2 to 12.4 million) became new gun owners (4.2% of U.S. adults). The annual number of new owners declined monotonically, from 3.6 million in 2021 to 1.9 million by 2024. Women made up 46.3% (CI, 41.4% to 51.6%) of new owners; 46.1% (CI, 41.0% to 51.4%) were Hispanic and/or people of color; and 7.8 million lived in a household without firearms at the time of their earliest purchase, newly exposing 9.0 million other adults (CI, 7.5 to 10.6 million) and 6.6 million children (CI, 5.2 to 8.0 million) to household firearms. LIMITATION: Retrospective assessment of when respondents purchased firearms. CONCLUSION: These findings underscore the need for periodic survey-based assessments of firearm exposure and suggest that the risk for violent death has likely increased substantially for millions of Americans who became new gun owners and for millions of other adults and children who were newly exposed to the risks of living in households with guns. PRIMARY FUNDING SOURCE: Joyce Foundation, Fund for a Safer Future, and Robert Wood Johnson Foundation.

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Risk-Guided Antihypertensive Treatment Eligibility in Older Adults Under Updated Hypertension Guidelines.

Mangalesh S, Rossi R, Nouri A … +2 more , Damluji AA, Nanna MG

Ann Intern Med · 2026 Jun · PMID 41839034 · Full text

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Advancing Clinical Mastery: An Essential Element of Primary Care Revitalization.

Kravitz RL

Ann Intern Med · 2026 Apr · PMID 41839033 · Publisher ↗

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Annals Of Internal Medicine[JOURNAL]

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