Searches / Journal Of The Formosan Medical Association = Taiwan Yi Zhi[JOURNAL]

Journal Of The Formosan Medical Association = Taiwan Yi Zhi[JOURNAL]

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Community-based Helicobacter pylori screening and empiric eradication in health promotion program participants aged 50-69 Years in Chiayi county, Taiwan.

Ding YJ, Wen HP, Chen WM … +7 more , Tung WL, Hsieh YY, Chen YH, Chang KC, Chao WH, Cheng HH, Chang TS

J Formos Med Assoc · 2026 Jun · PMID 42315471 · Publisher ↗

BACKGROUND: Taiwan has launched community-based Helicobacter pylori (H. pylori) screening programs in select areas. However, in many parts of Taiwan, the most effective treatment strategies remain unclear. METHODS: In Ju... BACKGROUND: Taiwan has launched community-based Helicobacter pylori (H. pylori) screening programs in select areas. However, in many parts of Taiwan, the most effective treatment strategies remain unclear. METHODS: In July 2023, H. pylori stool antigen (HpSA) screening for adults aged 50-69 years was added to the county-wide community-based health promotion program conducted by the Chiayi County Health Bureau. This single-center retrospective analysis included 531 HpSA-positive individuals who were evaluated at Chiayi Chang Gung Memorial Hospital between July 2023 and June 2024. RESULTS: Among the 5749 screened adults aged 50-69 years in Chiayi County, HpSA positivity was 25.6% (95% CI, 24.5-26.7). Of 1470 HpSA-positive individuals identified through screening, 531 (36.1%) were evaluated at the study hospital. Of them, 458 (86.3%) underwent endoscopy, which identified gastric ulcers in 24.5%, duodenal ulcers in 17.0%, and both in 6.6%. Rapid urease test and histological assessment were performed in 316 and 158 patients, respectively, yielding a positivity rate of 87.0% and 86.7% respectively. Among the 441 patients with available follow-up data, eradication rates were 94.7% (216/228) for those receiving 14-day clarithromycin-based triple therapy and 93.1% (149/160) for those receiving pooled 7-14-day concomitant therapy (p = 0.508). Reverse hybrid therapy achieved a 100% eradication rate in 20 patients, without significant difference compared to triple therapy (p = 0.293). CONCLUSION: Among screened adults aged 50-69 years in Chiayi County, HpSA positivity was approximately 25.6%. Fourteen-day triple therapy, 7-14-day concomitant therapy and reverse hybrid therapy all achieved high eradication rates.
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Response to the comment letter on 'Effectiveness of comprehensive geriatric assessment in frail older inpatients'.

Kuo HL, Chou YC, Chang WN … +2 more , Chang KV, Chan DC

J Formos Med Assoc · 2026 Jun · PMID 42315470 · Publisher ↗

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Comment on:Paradigm shift in gestational diabetes mellitus management: Integrating Ribonuclease L with precision nursing and digital health interventions.

Lu H

J Formos Med Assoc · 2026 Jun · PMID 42315469 · Publisher ↗

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Plateau patella angle reference range for Taiwanese TKA: scope, calibration, and outcome considerations.

Zhong X, Wu L

J Formos Med Assoc · 2026 Jun · PMID 42315468 · Publisher ↗

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Response to "Comment on 'Consensus of the hematology society of Taiwan on the management of paroxysmal nocturnal hemoglobinuria (PNH)'".

Huang WH, Hou HA, Chou WC … +3 more , Wu YF, Chen YC, Ko BS

J Formos Med Assoc · 2026 Jun · PMID 42315467 · Publisher ↗

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Comment on"Serum and tissue IGFBP2 as a prognostic biomarker in gastric adenocarcinoma: A multi-cohort clinical validation study".

Cheng T

J Formos Med Assoc · 2026 Jun · PMID 42309882 · Publisher ↗

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Response to "Comment on Multi-vendor, multi-field strength validation of MRI-Proton density fat fraction for fat quantification: A standardized phantom study".

Yen KC, Wu CH

J Formos Med Assoc · 2026 Jun · PMID 42303559 · Publisher ↗

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Response to the letter to the editor regarding "Use of technetium-99m-pyrophosphate single-photon emission computed tomography/computed tomography in monitoring therapeutic changes of RNA interference therapeutics in patients with hereditary transthyretin amyloid cardiomyopathy".

Hung YH, Cheng MF, Chao CC … +1 more , Lin YH

J Formos Med Assoc · 2026 Jun · PMID 42303558 · Publisher ↗

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The first genome-wide association study on pediatric obesity in Taiwan.

Wu HR, Liu TY, Chen CM … +1 more , Tsai FJ

J Formos Med Assoc · 2026 Jun · PMID 42297719 · Publisher ↗

BACKGROUND: The global prevalence of pediatric obesity has risen sharply, increasing from 0.7% to 5.6% in girls and from 0.9% to 7.8% in boys between 1975 and 2016. Genetic factors contribute an estimated 50-80% to obesi... BACKGROUND: The global prevalence of pediatric obesity has risen sharply, increasing from 0.7% to 5.6% in girls and from 0.9% to 7.8% in boys between 1975 and 2016. Genetic factors contribute an estimated 50-80% to obesity risk. In 2007, FTO was identified as the first obesity-associated gene through a genome-wide association study (GWAS), but research in Asian pediatric populations remains limited. This study investigated the genetic architecture of pediatric obesity in Taiwanese children. METHODS: Data were obtained from the China Medical University Hospital Biobank. Obese cases were defined as BMI above 95th percentile for age and sex; controls had BMI between the 3rd and 50th percentiles. GWAS was performed on 5854 cases and 12,343 controls aged 2-17 years using the TPMv1 customized single nucleotide polymorphism (SNP) array. Polygenic risk scores (PRS) were constructed with PRSice2. Phenome-wide association studies (PheWAS) evaluated PRS-disease associations, and network analyses were conducted via Ingenuity Pathway Analysis. (IPA). RESULTS: GWAS identified 367 SNPs associated with pediatric obesity at P < 1 × 10, with leading SNPs rs79500119 (ASB3, chromosome 2) and rs74617772 (near FTO, chromosome 16). Obesity cases had significantly higher PRS (P < 0.05). PheWAS linked obesity PRS to type 2 diabetes, hypertension, respiratory infections, liver disease, and precocious puberty. Network analysis highlighted the insulin-AKT pathway as potentially central to pathogenesis. CONCLUSIONS: This first GWAS of pediatric obesity in Taiwan revealed novel, population-specific genetic associations. The PRS offers potential for metabolic risk stratification, and the insulin-AKT pathway represents a relevant biological framework for further investigation of pediatric obesity pathogenesis.
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Total kidney volume and frailty severity in ADPKD: A pilot observation.

Wang J, Chao CT

J Formos Med Assoc · 2026 Jun · PMID 42288451 · Publisher ↗

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Age-stratified patterns of sarcopenic traits: Evidence for a life-course screening strategy from young adulthood to old age.

Wang TY, Lee CH, Hong WW … +4 more , Lin CW, Liang CL, Wu CH, Hung WC

J Formos Med Assoc · 2026 Jun · PMID 42288450 · Publisher ↗

AIM: Recent guidelines (AWGS 2025) advocate for a life-course approach to muscle health, lowering the screening age and redefining physical performance as an outcome measure rather than a diagnostic criterion. This study... AIM: Recent guidelines (AWGS 2025) advocate for a life-course approach to muscle health, lowering the screening age and redefining physical performance as an outcome measure rather than a diagnostic criterion. This study investigates the prevalence and clinical correlates of discordant sarcopenic traits across diverse age strata in a cross-sectional Taiwanese adult cohort. METHODS: This single-center study analyzed 2991 Taiwanese adults aged ≥20 years using DXA and functional assessments. AWGS thresholds were applied as absolute benchmarks across all ages to identify early-onset phenotypes and discordant patterns. Regression and trend analyses evaluated patterns among sarcopenia components. RESULTS: A distinct, age-dependent difference in sarcopenia phenotypes was identified across strata. In those <50 with low muscle mass, the predominant pattern was low physical performance with preserved strength. A critical age-related trend occurred at ages 50-64, where strength deficits emerged significantly. Older groups progressed toward combined deficits in both strength and performance. CONCLUSIONS: Sarcopenic traits manifest as age-stratified phenotypes. High prevalence of low performance with preserved strength in younger adults justifies separating performance from core diagnostic algorithms. Strength deficits in middle-aged adults provide epidemiological support for lowering the screening age to 50. These findings suggest that future screening strategies may consider prioritizing performance screening in early adulthood and initiate targeted strength assessments from age 50.
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From "Deqi" to Sng: Can the sensations of acupuncture advance from terminological consensus to standardization?

Lai Y, Zheng L

J Formos Med Assoc · 2026 Jun · PMID 42285875 · Publisher ↗

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Comment on "SGLT2 inhibitors and geriatric syndromes in older adults with type 2 diabetes: A real-world cohort study".

Tan Y, Zhang B

J Formos Med Assoc · 2026 Jun · PMID 42276873 · Publisher ↗

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Reply to: Comment on "Genetic testing for adult-onset neurodegenerative diseases: A clinical perspective" by Dr. Pandey.

Lee NC, Lin CH, Chien YH … +1 more , Hwu WL

J Formos Med Assoc · 2026 Jun · PMID 42276872 · Publisher ↗

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Response to comment on "Serum ANGPTL4 as a biomarker for hemorrhagic transformation after endovascular therapy in acute ischemic stroke".

Guo F, Zheng C

J Formos Med Assoc · 2026 Jun · PMID 42276871 · Publisher ↗

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Comment on "Serum ANGPTL4 as a biomarker for hemorrhagic transformation after endovascular therapy in acute ischemic stroke".

Fan X

J Formos Med Assoc · 2026 Jun · PMID 42276870 · Publisher ↗

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Authors' response to the Letter to the Editor on "From Deqi to sng: Can the sensations of acupuncture advance from terminological consensus to standardization?".

Chen CC, Sun WZ

J Formos Med Assoc · 2026 Jun · PMID 42276869 · Publisher ↗

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Comment on "2025 Taiwan guidelines on the drug therapy of lung cancer: Advanced non-squamous cell carcinoma with actionable oncogenic drivers".

Sayana SB

J Formos Med Assoc · 2026 Jun · PMID 42270504 · Publisher ↗

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Comment on "Ethics for neurodegenerative disorder patient care".

Yao Y, Zhu C

J Formos Med Assoc · 2026 Jun · PMID 42270503 · Publisher ↗

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The unmeasured role of concomitant medication dynamics and immortal time bias in SGLT2 inhibitors study.

Jia Z, Li M

J Formos Med Assoc · 2026 Jun · PMID 42270502 · Publisher ↗

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