American Journal Of Therapeutics[JOURNAL]

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Efficacy of Switching From Multidrug Regimens to Dolutegravir and Lamivudine in Virologically Suppressed HIV-1-Infected Individuals: A Systematic Review and Meta-Analysis.

Azeem MB, Khurram L, Arif F … +6 more , Rani S, Raja A, Kumar S, Xxx A, Rehman HU, Oduoye MO

Am J Ther · 2025 Oct · PMID 41056027 · Publisher ↗

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Clopidogrel Versus Aspirin After Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Yasmin F, Ali Fahim MA, Ahmed M … +5 more , Tabassum M, Moeed A, Asghar MS, Shaharyar M, Alraies MC

Am J Ther · 2025 Oct · PMID 41056026 · Publisher ↗

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Xanomeline/Trospium (Cobenfy): A Novel Approach for the Treatment of Schizophrenia in Adults.

Miron AA, Ifteni PI, Nguyen T … +1 more , Dima L

Am J Ther · 2025 Nov-Dec 01 · PMID 41056016 · Publisher ↗

BACKGROUND: Schizophrenia is characterized by 3 main groups of symptoms: positive, negative, and cognitive. Traditional antipsychotics primarily address positive symptoms via dopamine D2 receptor blockade but often cause... BACKGROUND: Schizophrenia is characterized by 3 main groups of symptoms: positive, negative, and cognitive. Traditional antipsychotics primarily address positive symptoms via dopamine D2 receptor blockade but often cause side effects like movement disorders, sedation, and hormonal imbalances xanomeline/trospium, Food and Drug Administration (FDA) approved for the treatment of schizophrenia in adults, represents a novel, nondopaminergic approach to schizophrenia treatment, without being categorized as an antipsychotic. Xanomeline is a muscarinic receptor agonist (mainly M1 and M4) that reduces dopamine release in the associative striatum, a region linked to psychotic symptoms, while sparing sensorimotor regions involved in movement and endocrine regulation. M1 receptor stimulation also influences Gamma-aminobutyric acid (GABA)/glutamate pathways that modulate the ventral tegmental area, contributing to dopaminergic balance. PHARMACODYNAMICS AND PHARMACOKINETICS: Xanomeline binds to all 5 muscarinic receptor subtypes, exerting central effects. Trospium, a peripherally acting anticholinergic with limited blood-brain barrier penetration, mitigates xanomeline's peripheral cholinergic side effects, such as nausea, vomiting, and sweating. However, higher doses of trospium may introduce additional peripheral side effects. Xanomeline undergoes extensive liver metabolism, whereas trospium is primarily excreted unchanged in urine. The combination is contraindicated in patients with moderate to severe hepatic or renal impairment or urinary retention. CLINICAL TRIALS: EMERGENT-1 was a phase 2 trial, whereas the subsequent 2 EMERGENT trials were phase 3 studies evaluating the safety, tolerability, and efficacy of xanomeline/trospium compared with placebo in adult patients diagnosed with schizophrenia. The final 2 EMERGENT trials were 52-week, open-label studies designed to assess the long-term safety and efficacy of the drug. Xanomeline/trospium treatment significantly reduced Positive and Negative Syndrome Scale (PANSS) total score across the 2 phase 3 trials. THERAPEUTIC ADVANCE: Xanomeline/trospium represents an innovative drug approach, targeting the improvement in positive, cognitive, and negative symptoms in individuals with schizophrenia. This combination seeks to provide therapeutic benefits while displaying a different adverse effect profile than antipsychotic medications and potentially reducing the treatment discontinuation risk.

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Lithium Carbonate Monotherapy for Nonaffective Behavioral Decompensation in Low-Functioning Autism.

Naguy A, Abdelaal A, Elsori D … +1 more , Alamiri B

Am J Ther · 2026 Mar-Apr 01 · PMID 41026914 · Publisher ↗

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Unveiling the Therapeutic Landscape of Salvia fruticosa: A Systematic Exploration of Pharmacology and Clinical Promise.

Ahmad F

Am J Ther · 2026 Jan-Feb 01 · PMID 41004275 · Publisher ↗

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Dobutamine-Associated Superficial Thrombosis.

Aoun I, Dahmani I, Fatma Z … +5 more , Kaabi W, Debbeche S, Daghfous R, Aouinti I, El Aidli S

Am J Ther · 2025 Nov-Dec 01 · PMID 40986652 · Publisher ↗

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Associations of Increasing Serum Lactate Dehydrogenase Levels With Chemotherapy Responsiveness and Survival in Patients With Extensive Disease Small Cell Lung Cancer.

Tas F, Ozturk A, Erturk K

Am J Ther · 2026 Mar-Apr 01 · PMID 40965371 · Publisher ↗

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Efficacy of BPaL and BPaLM Regimens in Treating Drug-Resistant Tuberculosis: A Systematic Review and Meta-Analysis.

Sridharan K, Sivaramakrishnan G

Am J Ther · 2025 Sep · PMID 40960978 · Publisher ↗

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From Critique to Cautionary Tale: A Methodological Response to Qasim's Flawed Appraisal of Proton Pump Inhibitors for Upper Gastrointestinal Bleeding Prevention in Dual Antiplatelet Therapy.

Arredondo Montero J

Am J Ther · 2025 Sep · PMID 40956983 · Publisher ↗

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Re-evaluating Ketamine Delivery Modalities in Treatment-Resistant-Depression: Opportunities Beyond Intravenous Use.

Kainat K, Raza MA

Am J Ther · 2025 Sep · PMID 40899867 · Publisher ↗

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Risk Factors for Antibodies Response to Adalimumab: A Systematic Review and Meta-analysis.

Gao J, Zhao M, Sun C … +5 more , Wen T, Pang T, Liu Y, Chen W, Zhang F

Am J Ther · 2025 Aug · PMID 40899862 · Publisher ↗

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Letter to the Editor: Current Knowledge and Implementation of Therapeutic Strategies in Cardio-Oncology: A National Physician-Based Survey.

Siddiqui D, Tariq H

Am J Ther · 2025 Sep-Oct 01 · PMID 40828631 · Publisher ↗

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Hypotension Shock Caused by Combination of Nifedipine and Itraconazole.

Yang XL, Chen YJ, Zhang HF

Am J Ther · 2025 Aug · PMID 40815790 · Publisher ↗

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Intravenous Iron Therapy in Patients With Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.

Pinilla J, Jaramillo S, Patel R … +4 more , Nava N, Oliveira Amador WF, Samaniego MA, Modi K

Am J Ther · 2025 Aug · PMID 40815789 · Publisher ↗

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Coronary Artery Calcium as a Key Indicator of Chemotherapy Cardiotoxicity in Patients With Colorectal Cancer.

Jabri A, Kumar S, Maligireddy AR … +11 more , Anaya F, Matta M, Dehaini H, Sukhon F, Al-Abdouh A, Hammad N, Bloomingdale R, Dixon S, Trivax J, Aneja A, Balakumaran K

Am J Ther · 2025 Aug · PMID 40815788 · Publisher ↗

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