Searches / Nature Cell Biology[JOURNAL]

Nature Cell Biology[JOURNAL]

Sun 200 papers

Author Correction: Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Romani P, Nirchio N, Arboit M … +20 more , Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S

Nat Cell Biol · 2026 Jul · PMID 42399457 · Publisher ↗

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An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.

Liu RF, Huang M, Shen Y … +10 more , Shao M, Jing J, Xu N, Tang L, Liu B, Shi J, Chen F, Hao ZZ, Jiang X, Liu S

Nat Cell Biol · 2026 Jul · PMID 42393360 · Publisher ↗

The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-b... The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and characterized 78 detailed cell types in the macaque AIC, revealing the diversity and specialization of this region in cell type, connectivity profile, signal-processing strategy and metabolic characteristics. Among these, we identified two transcriptomically and morphoelectrically defined von Economo neuron (VEN) subtypes, DSG2-expressing VEN-L and POC5-expressing VEN-S, transcriptomically relating to extratelencephalic and corticothalamic projection neurons, respectively. We also uncovered a previously underappreciated signal-processing strategy by VENs, whereby the geometry of the dendrite-originating axon reshapes action potential dynamics and enhances somatic responsiveness to deep-layer synaptic inputs. Our multimodal atlas establishes a molecular and functional framework for investigating the circuit principles underlying cognitive processes in the primate AIC.

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Primate neurons with special signalling logic.

Romanov RA

Nat Cell Biol · 2026 Jul · PMID 42393359 · Publisher ↗

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Cell surface liposome binding (CLiB) allows lipid-binding probe engineering via high-throughput screening.

Nishimura T, Tsuboyama K, Nakagaki Y … +6 more , Lu SL, Ishino Y, Kono N, Noda T, Yamamoto E, Mizushima N

Nat Cell Biol · 2026 Jul · PMID 42393358 · Publisher ↗

Lipid-binding domains, traditionally isolated from natural proteins, are essential tools for probing membrane lipid dynamics and specialized cellular compartments. Despite diverse applications, a general strategy for the... Lipid-binding domains, traditionally isolated from natural proteins, are essential tools for probing membrane lipid dynamics and specialized cellular compartments. Despite diverse applications, a general strategy for their engineering remains elusive. Here we present a robust and high-throughput method for monitoring protein-lipid interactions, named the cell surface liposome binding (CLiB) assay. Using the assay, we conducted directed evolution of the PX domain from SnxA, isolating high-affinity variants specific for phosphatidylinositol 3,5-bisphosphate (PI(3,5)P). Combining the CLiB assay with next-generation sequencing enabled parallel analysis of >6,000 clones, comprehensively identifying key residues critical for lipid binding. An engineered variant, PX-SnxA, functioned as a lipid biosensor in yeast and mammalian cells, visualizing PI(3,5)P-enriched membrane subdomains upon hyperosmotic shock and during microautophagy, thereby suggesting localized PI(3,5)P synthesis within spatially restricted regions. This study provides a framework for on-demand generation of lipid-binding probes, facilitating the discovery of membrane compartments characterized by unique lipid compositions.

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Mapping the human female reproductive tract.

Gomez-Lopez N, Lee S

Nat Cell Biol · 2026 Jul · PMID 42393357 · Publisher ↗

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Learning from stem cell-based embryo models.

Nat Cell Biol · 2026 Jul · PMID 42387152 · Publisher ↗

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Why the temporal dimension matters in cellular signalling.

Yang S, Jin F

Nat Cell Biol · 2026 Jun · PMID 42380615 · Publisher ↗

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Transcription factor condensates as storage.

Chen L, Liu Z

Nat Cell Biol · 2026 Jun · PMID 42373741 · Publisher ↗

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Author Correction: Spatial regulation of VEGF receptor endocytosis in angiogenesis.

Nakayama M, Nakayama A, van Lessen M … +11 more , Yamamoto H, Hoffmann S, Drexler HCA, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH

Nat Cell Biol · 2026 Jun · PMID 42362940 · Publisher ↗

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Mitochondria-endoplasmic reticulum contact sites as hubs where mitochondria acquire iron.

Nat Cell Biol · 2026 Jun · PMID 42362939 · Publisher ↗

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Cis and trans regulatory mechanisms of extrachromosomal DNA segregation.

Xie Y, Lim JYS, Liu W … +5 more , Gilbreath C, Sun X, Qiao K, Kim YJ, Wu S

Nat Cell Biol · 2026 Jun · PMID 42342951 · Publisher ↗

Extrachromosomal DNAs (ecDNAs) attach to chromosomes during mitosis for random segregation and promote cancer heterogeneity. However, the mechanism governing ecDNA-chromosome mitotic interactions remains poorly understoo... Extrachromosomal DNAs (ecDNAs) attach to chromosomes during mitosis for random segregation and promote cancer heterogeneity. However, the mechanism governing ecDNA-chromosome mitotic interactions remains poorly understood. Here we show that ecDNAs tether to histone H3 lysine 27 acetylation (H3K27ac)-marked chromatin during mitosis. Depleting H3K27ac disrupts this interaction. Diverse bromodomain proteins, as H3K27ac readers, stabilize ecDNA-chromosome binding in a context-dependent and complementary manner. Although disrupting the Mediator complex in asynchronous cells detaches ecDNAs from mitotic chromosomes, Mediator and active Pol II are absent from ecDNAs during mitosis, suggesting that ecDNAs are transcriptionally silent during mitosis. Instead, inactive Pol II mediates ecDNA attachment. Furthermore, CRISPR interference targeting transcriptional regulatory elements on ecDNA impairs ecDNA segregation. Mis-segregated ecDNAs were expelled into the cytosol, leading to diminished oncogene expression and a reversal of therapy resistance. Our research provides universal cis and trans regulatory mechanisms of ecDNA segregation, offering deeper insight into ecDNA-driven oncogenesis.

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Author Correction: DNA nanodevices detect an acidic nanolayer on the lysosomal surface.

Zhang Y, Hu M, Meng Y … +13 more , Wang X, Huang F, Li P, Zhuo Y, Chen D, Wang Z, Zhang Q, Wu H, He Y, Du Y, Xu H, Qiu L, Tan W

Nat Cell Biol · 2026 Jun · PMID 42337100 · Publisher ↗

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Author Correction: Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing.

Wang B, Wang Y, Pan T … +14 more , Zhou L, Ran Y, Zou J, Yan X, Wen Z, Lin S, Ren A, Wang F, Liu Z, Liu T, Lu H, Yang B, Zhou F, Zhang L

Nat Cell Biol · 2026 Jun · PMID 42332202 · Publisher ↗

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Mediator subunit MED4 enforces metastatic dormancy in breast cancer.

Bae SS, Ling HH, Zhang J … +8 more , Chen Y, Chen H, Kumar D, Saw AK, Rai K, Viny AD, DePinho RA, Giancotti FG

Nat Cell Biol · 2026 Jun · PMID 42332201 · Publisher ↗

Long-term survival in breast cancer is often limited by metastatic recurrence arising from disseminated cancer cells that persist in a dormant state. The mechanisms that enable these dormant cells to survive and subseque... Long-term survival in breast cancer is often limited by metastatic recurrence arising from disseminated cancer cells that persist in a dormant state. The mechanisms that enable these dormant cells to survive and subsequently reawaken remain incompletely understood. Here an unbiased genome-scale genetic screen identified Med4 as a cancer cell-intrinsic gatekeeper in metastatic reactivation. Correspondingly, MED4 haploinsufficiency was found to be prevalent in metastatic breast cancer and associated with poorer clinical outcomes. Syngeneic mouse metastasis models revealed that MED4 enforces metastatic dormancy. Mechanistically, and unexpectedly given the canonical role of the Mediator complex in transcriptional activation, MED4 suppresses enhancer priming (H3K4me1) and activation (H3K27ac). Loss of a single Med4 allele disrupts enhancer poise, leading to extracellular matrix remodelling and integrin-mediated mechanotransduction programmes that ultimately drive metastatic outgrowth. Together, these findings establish MED4 as a key regulator of breast cancer cell dormancy and nominate MED4 haploinsufficiency as a potential predictive biomarker for patients at high risk of metastatic relapse.

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Rewiring dormancy.

Tsuji T, Ghajar CM

Nat Cell Biol · 2026 Jun · PMID 42332200 · Publisher ↗

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Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.

Nguyen ST, Watson RL, Gao F … +14 more , Campos M, Jung S, Seabrook LJ, Kim MC, Hanse EA, Yang Y, Kong M, Zuckerman JE, Pereira RC, Salusky IB, Catz SD, Jang C, Skowronska-Krawczyk D, Albrecht LV

Nat Cell Biol · 2026 Jun · PMID 42321517 · Publisher ↗

Lysosomes are integral organelles that communicate cellular status to an entire tissue through mechanisms that are poorly defined. Here we developed an unbiased platform, integrating human plasma metabolomes and single-l... Lysosomes are integral organelles that communicate cellular status to an entire tissue through mechanisms that are poorly defined. Here we developed an unbiased platform, integrating human plasma metabolomes and single-lysosome metabolomics, and show the byproducts of proteolysis are an unexpected class of signalling molecules. We show that dimethylarginine is a lysosomal-derived metabolite and a predictor of patient morbidity. Genetic depletion of a lysosomal exporter, cystinosin, accumulated dimethylarginine in lysosomes. Leveraging a lysosomal storage disease with cystinosin mutations, we show that the rapid plasticity of dimethylarginine compartmentalization ensures cell and tissue homeostasis. Strikingly, lysosomal entrapment of dimethylarginine in patients and disease models corresponds with lipid accumulation, lipid droplets and lipotoxicity. Exogenously restoring asymmetric dimethylarginine buffers oxidative stress, decreasing lipid peroxidation and cell death. These data show that dimethylarginine engages an interorganellar process-with peroxisomes, lysosomes and lipid droplets-that confers a crucial adaptive response mechanism.

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Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain.

Zhang X, Chen L, Zhu B … +17 more , Wang L, Chen C, Hong M, Huang Y, Li H, Han H, Cai B, Yu W, Yin S, Yang L, Yang Z, Liu M, Zhang Y, Mao Z, Wu Y, Liu M, Li D

Nat Cell Biol · 2026 Jun · PMID 42310430 · Publisher ↗

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Author Correction: Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution.

Yue Y, Zong W, Li X … +17 more , Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, Zhou B, Chen L, Xiao W, Cheng H, He A

Nat Cell Biol · 2026 Jun · PMID 42303821 · Publisher ↗

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Author Correction: MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains.

Zhang Y, Xia Y, Wang X … +6 more , Xia Y, Wu S, Li J, Guo X, Zhou Q, He L

Nat Cell Biol · 2026 Jun · PMID 42303820 · Publisher ↗

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Author Correction: BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

Peng G, Yim EK, Dai H … +6 more , Jackson AP, van der Burgt I, Pan MR, Hu R, Li K, Lin SY

Nat Cell Biol · 2026 Jun · PMID 42298061 · Publisher ↗

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