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Blood[JOURNAL]

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SIGN of the times: DC-SIGN and the follicular lymphoma niche.

Tobin JWD, Gandhi MK

Blood · 2026 Apr · PMID 42060334 · Publisher ↗

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Plasmodium gets inside through the back door.

Jajosky RP, Stowell SR

Blood · 2026 Apr · PMID 42060333 · Full text

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A siRNA slice of PAI.

Lee GM

Blood · 2026 Apr · PMID 42060332 · Publisher ↗

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Checkpoint blockade in HL: is transplant still needed?

Chen AI

Blood · 2026 Apr · PMID 42060331 · Publisher ↗

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Nuclear architecture: a mechanical lever for HSC fitness.

Rezk R

Blood · 2026 Apr · PMID 42060330 · Publisher ↗

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Toggling STAT to restore T-cell homeostasis in ITP.

Semple JW

Blood · 2026 Apr · PMID 42060329 · Publisher ↗

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Plasmin tames lung inflammation by redirecting immune cells.

Kapur R

Blood · 2026 Apr · PMID 42060328 · Publisher ↗

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Immune clues to infection risk in myeloma.

Ainley L, Yong K

Blood · 2026 Apr · PMID 42060327 · Publisher ↗

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Dissecting the genetic threads underlying the fabric of pediatric myelofibrosis.

Al-Jumaili Z, Parisi X

Blood · 2026 Apr · PMID 42060324 · Publisher ↗

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Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesis.

Bariboloka KT, Serrano-Saenz S, Savcigil DP … +28 more , Spoeck S, Poss RE, Schreurs LD, Löber J, Serin N, Valiulis J, Nugraha K, Gangarossa G, Lütz A, Reese M, Klein S, Enssle JC, Büttner R, Kashkar H, Peifer M, Chapuy B, Knittel G, Labi V, Villunger A, Nguyen PH, Scheich S, Oellerich T, Walczak H, Flümann R, Jachimowicz RD, Hallek MJ, Reinhardt HC, Annibaldi A

Blood · 2026 Apr · PMID 42024475 · Publisher ↗

Diffuse large B cell lymphoma (DLBCL) is a highly heterogenous malignant disease that remains a major clinical challenge as relapsed and refractory disease is difficult to treat. Apoptosis evasion is a major feature of D... Diffuse large B cell lymphoma (DLBCL) is a highly heterogenous malignant disease that remains a major clinical challenge as relapsed and refractory disease is difficult to treat. Apoptosis evasion is a major feature of DLBCL. However, while the suppression of intrinsic apoptosis has long been recognized as a lymphoma-promoting event, the role of extrinsic apoptosis has remained poorly defined. Here, we demonstrated at the genetic level that expression of cFLIP, the most crucial, non-redundant inhibitor of extrinsic apoptosis, in B cells is necessary for the development of diffuse large B cell lymphoma (DLBCL) in an autochthonous murine model. Indeed, B cell-specific deletion of Cflar, the gene encoding for cFLIP, prevented lymphomagenesis mediated by oncogenic Myd88 and overexpression of BCL2. In human lymphoma cells, we showed that the absence of cFLIP sensitizes ABC- but not GCB DLBCL subtype cells to TRAIL- or LPS-induced, Caspase-8-mediated apoptosis. Furthermore, we unveiled a cell death-independent role of cFLIP in the suppression of pro-inflammatory cytokines at the transcriptional level, selectively in the ABC subtype.These results indicate that the suppression of intrinsic apoptosis can support lymphomagenesis only if extrinsic apoptosis is properly controlled. Moreover, licensing extrinsic apoptosis via cFLIP deletion can efficiently promote the death of DLBCL cells despite the suppression of the intrinsic pathway. Overall, these data provide the rationale for the development of cFLIP inhibitors for the treatment of ABC DLBCL and possibly other haematological cancers.

Novel phosphatase-based regulatory loop for HbF expression.

De Franceschi L

Blood · 2026 Apr · PMID 42024402 · Publisher ↗

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Beyond the code: noncoding splicing rewires mutant SF3B1.

Barati Z, Schweiger MR

Blood · 2026 Apr · PMID 42024401 · Publisher ↗

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Common variants, rare disease: new insights into AML risk.

Wen S

Blood · 2026 Apr · PMID 42024400 · Publisher ↗

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What next after the first BITE of the CD19 cherry in ALL?

Fielding AK

Blood · 2026 Apr · PMID 42024399 · Publisher ↗

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lncRNA and protein team up to drive immune cell identity.

Erkeland SJ

Blood · 2026 Apr · PMID 42024398 · Publisher ↗

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Fueling, then wrecking the megakaryocyte ship.

Pincez T

Blood · 2026 Apr · PMID 42024397 · Publisher ↗

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Donor T cells on double duty: VCAR33 for AML after transplant.

Geyer MB

Blood · 2026 Apr · PMID 42024396 · Publisher ↗

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Engineering ABO histocompatibility in transplant and beyond.

West LJ

Blood · 2026 Apr · PMID 42024395 · Publisher ↗

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