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Archives Of Ophthalmology[JOURNAL]

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Correlation of recognition visual acuity with posterior retinal structure in advanced retinopathy of prematurity.

Wallace DK, Bremer DL, Good WV … +4 more , Fellows R, Summers CG, Tung B, Hardy RJ

Arch Ophthalmol · 2012 Dec · PMID 22892757 · Publisher ↗

OBJECTIVE To compare Early Treatment Diabetic Retinopathy Study visual acuity outcome with retinal structural outcome at the 6-year follow-up examination of infants randomized in the Early Treatment for Retinopathy of Pr... OBJECTIVE To compare Early Treatment Diabetic Retinopathy Study visual acuity outcome with retinal structural outcome at the 6-year follow-up examination of infants randomized in the Early Treatment for Retinopathy of Prematurity study. METHODS We compared the results in 606 eyes of subjects in whom both functional (visual acuity) and retinal structural assessments were obtained at age 6 years. Visual acuity assessments were performed by masked testers, and retinal examinations were performed by certified ophthalmologists. MAIN OUTCOME MEASURES Visual acuity and retinal structure at age 6 years. RESULTS Concordant outcomes occurred in 462 eyes (76.2%): 402 eyes had favorable functional and structural outcomes and 60 eyes had unfavorable functional and structural outcomes. Discordant outcomes occurred in 92 eyes (15.2%): 86 eyes had unfavorable functional and favorable structural outcomes and 6 eyes had favorable functional and unfavorable structural outcomes. Of the 86 eyes with unfavorable functional and favorable structural outcomes, 43 had optic atrophy (23 eyes) and/or retinal abnormalities that were less severe than those considered to be unfavorable (32 eyes). In 52 eyes (8.6%), retinal structure could not be assessed or the visual acuity was untestable. CONCLUSION Posterior pole appearance correlates well with visual acuity in 6-year-old infants with a history of advanced retinopathy of prematurity. APPLICATION TO CLINICAL PRACTICE When the retinal structure is normal but visual acuity is poor in infants with a history of severe retinopathy of prematurity, other diagnoses such as optic atrophy and cortical visual impairment could at least partially account for the discrepancy. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00027222.

A combined index of structure and function for staging glaucomatous damage.

Medeiros FA, Lisboa R, Weinreb RN … +3 more , Girkin CA, Liebmann JM, Zangwill LM

Arch Ophthalmol · 2012 May · PMID 22826832

OBJECTIVES: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage. METHODS: Observational study including 333 glaucomatous eyes (295 with perimetric g... OBJECTIVES: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage. METHODS: Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects.All the eyes were tested with standard automated perimetry and spectral domain optical coherence tomography within 6 months. Estimates of the number of retinal ganglion cells (RGCs) were obtained from standard automated perimetry and spectral domain optical coherence tomography and a weighted averaging scheme was used to obtain a final estimate of the number of RGCs for each eye. The CSFI was calculated as the percent loss of RGCs obtained by subtracting estimated from expected RGC numbers. The performance of the CSFI for discriminating glaucoma from normal eyes and the different stages of disease was evaluated by receiver operating characteristic curves. RESULTS: The mean CSFI, representing the mean estimated percent loss of RGCs, was 41% and 17% in theperimetric and preperimetric groups, respectively(P.001). They were both significantly higher than the mean CSFI in the healthy group (P.001). The CSFI had larger receiver operating characteristic curve areas than isolated indexes of structure and function for detecting perimetric and preperimetric glaucoma and differentiating among early, moderate, and advanced stages of visual field loss. CONCLUSION: An index combining structure and function performed better than isolated structural and functional measures for detection of perimetric and preperimetric glaucoma as well as for discriminating different stages of the disease.

Update on risk of endophthalmitis after intravitreal drug injections and potential impact of elimination of topical antibiotics.

Bhavsar AR, Stockdale CR, Ferris FL … +4 more , Brucker AJ, Bressler NM, Glassman AR, Diabetic Retinopathy Clinical Research Network

Arch Ophthalmol · 2012 Jun · PMID 22801859 · Full text

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Endodrainage of macular schisis through optic disc pit.

Shukla D

Arch Ophthalmol · 2012 Jun · PMID 22801858 · Publisher ↗

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Subgroup analysis in the steroids for corneal ulcers trial.

Dulku S

Arch Ophthalmol · 2012 Jun · PMID 22801856 · Publisher ↗

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Systemic and ocular risks associated with therapies for macular degeneration: clarification vs confusion.

Friberg TR, Shah V, Bilonick RA

Arch Ophthalmol · 2012 Jun · PMID 22801854 · Publisher ↗

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Exacerbation of Susac syndrome retinopathy by interferon Beta-1a.

Laird PW, Newman NJ, Yeh S

Arch Ophthalmol · 2012 Jun · PMID 22801853 · Full text

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Endogenous endophthalmitis caused by salmonella serotype B in an immunocompetent 12-year-old child.

Rachitskaya AV, Flynn HW, Davis JL

Arch Ophthalmol · 2012 Jun · PMID 22801852 · Publisher ↗

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Significant treatment failure with intravitreous bevacizumab for retinopathy of prematurity.

Patel RD, Blair MP, Shapiro MJ … +1 more , Lichtenstein SJ

Arch Ophthalmol · 2012 Jun · PMID 22801851 · Publisher ↗

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Early refractive outcome after intravitreous bevacizumab for retinopathy of prematurity.

Harder BC, von Baltz S, Schlichtenbrede FC … +1 more , Jonas JB

Arch Ophthalmol · 2012 Jun · PMID 22801850 · Publisher ↗

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Pupillometric quantification of residual rod and cone activity in leber congenital amaurosis.

Kawasaki A, Munier FL, Leon L … +1 more , Kardon RH

Arch Ophthalmol · 2012 Jun · PMID 22801849 · Publisher ↗

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Ten-year evolution of retinopathy lesions in an older nondiabetic population.

Wang JJ, Rochtchina E, Kaushik S … +4 more , Kifley A, Cugati S, Wong TY, Mitchell P

Arch Ophthalmol · 2012 Jun · PMID 22801848 · Publisher ↗

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Intravitreous tissue plasminogen activator with pneumatic displacement in submacular hemorrhage.

Ratra D, Basia A

Arch Ophthalmol · 2012 Jun · PMID 22801847 · Publisher ↗

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Impact of availability of anti-vascular endothelial growth factor therapy on visual impairment and blindness due to neovascular age-related macular degeneration.

Campbell JP, Bressler SB, Bressler NM

Arch Ophthalmol · 2012 Jun · PMID 22801846 · Publisher ↗

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Uveitis exacerbation after varicella-zoster vaccination in an adult.

Sham CW, Levinson RD

Arch Ophthalmol · 2012 Jun · PMID 22801845 · Publisher ↗

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Effect of peripapillary vitreous opacity on retinal nerve fiber layer thickness measurement using optical coherence tomography.

Hwang YH, Kim YY

Arch Ophthalmol · 2012 Jun · PMID 22801844 · Publisher ↗

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Two cases of cosmetic iris implant explantation secondary to uveitis, glaucoma, and corneal decompensation.

Veldman PB, Behlau I, Soriano E … +2 more , Starling JC, Pineda R

Arch Ophthalmol · 2012 Jun · PMID 22801843 · Publisher ↗

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Educating a nation: renewing the promise.

Drake MV

Arch Ophthalmol · 2012 Jun · PMID 22801842 · Publisher ↗

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Predicting risk of diabetic retinopathy from retinal vessel analysis: personalized medicine in transition.

Cheung N, Wong TY

Arch Ophthalmol · 2012 Jun · PMID 22801841 · Publisher ↗

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Outcomes from a modified microkeratome-assisted lamellar keratoplasty for keratoconus.

Busin M, Scorcia V, Zambianchi L … +1 more , Ponzin D

Arch Ophthalmol · 2012 Jun · PMID 22801840 · Publisher ↗

To improve visual and refractive outcomes, microkeratome-assisted lamellar keratoplasty for the treatment of keratoconus (exchange of a 9.0-mm anterior recipient lamella with a 9.0-mm donor lamella, using a 200-μm head f... To improve visual and refractive outcomes, microkeratome-assisted lamellar keratoplasty for the treatment of keratoconus (exchange of a 9.0-mm anterior recipient lamella with a 9.0-mm donor lamella, using a 200-μm head for the former and a 300-μm head for the latter) was modified by adding a 6.5-mm incomplete full-thickness incision in the recipient bed before suturing the donor graft in place. After complete suture removal, 1 year postoperatively, best spectacle-corrected visual acuity was 20/40 or better in 92 of 97 eyes and 20/25 or better in 67 of 97 eyes; regular astigmatism was 4.5 diopters or worse in 86 of 97 eyes; endothelial cell loss averaged 20.4%. The disruption of the recipient's architecture induced by the full-thickness circular incision makes the final corneal shape closely resemble the physiologic curvature of the donor cornea, thus optimizing postoperative refractive error and spectacle-corrected visual acuity.
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