Ghatak T, Singh N, Bhalchandra RA
… +3 more, Gupta B, Halemani K, Mishra P
J Glob Infect Dis
· 2025 · PMID 41049257
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INTRODUCTION: Spontaneous venous thrombosis (SVT) in patients with dengue fever (DF) is a rare and complex phenomenon. The coexistence of thrombosis and hemorrhagic tendencies due to thrombocytopenia and dengue hemorrhag...INTRODUCTION: Spontaneous venous thrombosis (SVT) in patients with dengue fever (DF) is a rare and complex phenomenon. The coexistence of thrombosis and hemorrhagic tendencies due to thrombocytopenia and dengue hemorrhagic fever complicates management decisions. This systematic review aims to analyze the etiology, clinical presentation, management strategies, and outcomes reported in the English literature for such cases. METHODS: A comprehensive search of PubMed, CINAHL, Cochrane Library, Clinical Key, and Google Scholar databases was conducted up to October 31, 2024. Studies reporting SVT in DF were included, and data on demographics, diagnostic methods, treatment modalities, complications, and outcomes were extracted. This review adheres to Cochrane collaboration guidelines and follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement. RESULTS: Fifteen studies comprising 19 patients met the inclusion criteria. The mean age was 43.26 years, with a median onset of SVT occurring 6 days after fever onset. Majority (57.8%, 11/19) presented with thrombocytopenia (<52,000/mm³), and 57.8% (11/19) received subcutaneous low-molecular-weight heparin. Despite complexities, all patients survived without major bleeding complications. CONCLUSION: SVT in DF highlights the potential coexistence of thrombotic and hemorrhagic states. A standardized approach with anticoagulation appears effective in managing these challenging cases.
Rao M, Chen J, Lai W
… +8 more, Yang D, Wang L, Ouyang H, Yin Z, Wu Z, Chen Y, Zheng Q, Chen S
J Glob Infect Dis
· 2025 · PMID 41049255
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INTRODUCTION: Cervical cancer is strongly associated with human papillomavirus (HPV) infection. In this retrospective study, we analyzed the data of individuals who were tested for HPV at Binhaiwan Central Hospital in Do...INTRODUCTION: Cervical cancer is strongly associated with human papillomavirus (HPV) infection. In this retrospective study, we analyzed the data of individuals who were tested for HPV at Binhaiwan Central Hospital in Dongguan. METHODS: We retrospectively analyzed the data of 73,149 participants who underwent HPV examination at Binhaiwan Central Hospital in Dongguan. All participants were tested for HPV genotypes. We subsequently analyzed the infection rate and evaluated the distribution of HPV using the Chi-square test. RESULTS: The results suggest that the five most common HPV infection genotypes for men in the Dongguan area are different from those for women. The five most common high-risk HPV infections in women were the HPV52, 16, 58, 53, and 68 genotypes, whereas the five most common genotypes in men were HPV52, 16, 51, 58, and 39. The highest HPV infection positivity rate for female patients (31.68%) was in the 31-40 year age group, whereas the highest HPV infection positivity rate for male patients (40.47%) was in the 21-30 year age group. CONCLUSIONS: These findings provide a theoretical basis for epidemiological investigations, clinical prevention, and treatment of HPV infection and HPV vaccination in the region. The results could provide valuable information for healthcare professionals and policymakers to develop targeted prevention and screening strategies for reducing the burden of HPV-related diseases in this population.
Pandey P, Dixit A, Aggarwal R
… +5 more, Alam MQ, Chauhan C, Pandey N, Verma P, Yadav A
J Glob Infect Dis
· 2025 · PMID 41049254
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INTRODUCTION: Pap smear is a universally accepted screening test for early diagnosis of premalignant and malignant cervical lesions. Most studies show inflammation as the most common finding in Pap screening. Cervical in...INTRODUCTION: Pap smear is a universally accepted screening test for early diagnosis of premalignant and malignant cervical lesions. Most studies show inflammation as the most common finding in Pap screening. Cervical infections frequently lead to inflammation and pose significant clinical implications due to their potential to manifest as infertility, pelvic inflammatory disease, and pregnancy-related complications such as chorioamnionitis. METHODS: A prospective analysis of 3230 cervical liquid-based cytology smears collected during January 2017 to June 2018 was undertaken to identify prevalent infection types in cervical smears in a North Indian population catered at tertiary care hospital. RESULTS: A total of 2303 (71.3%) cases screened were in the age group of 21-40 years with a median age of 35.7 years. Totally 25.1% of cases had infection, of which the most common was bacterial vaginosis (BV) (58.07%), followed by (20.34%), human papillomavirus-related changes (11.34%), and (9.5%). Rare cases of herpes simplex virus, tuberculosis, and microfilaria were also reported. A total of 24 (5.09%) cases of BV had coexistent low-grade squamous intra-epithelial lesion as compared to 447 (94.9%) cases with BV alone (odds ratio = 0.77; 95% confidence interval: 0.4949-1.1877; = 0.2342), suggesting an association between the two; however, it was insignificant. CONCLUSION: Cervical cancer screening program for early detection of cervical neoplasia has efficiently led to a significant reduction in the incidence of cervical cancer worldwide. Notably, early detection and treatment of infectious lesions in cervix have also helped in reducing complications related to various infections. BV is recognized as the most common vaginal infection, and its association with cervical preneoplasia, as shown by recent studies, is being viewed as a possible etiology behind cervical neoplasia and needs to be explored through further research.
Alserr AHK, Wazir HAB, Abdullah MC
… +4 more, Amer MS, Salama YI, Zaqout F, Al Maashani SA
J Glob Infect Dis
· 2025 · PMID 41049253
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Mycotic aortic aneurysms (MAAs) are infective aneurysms that are associated with catastrophic outcomes if not diagnosed and treated on time. Less than 3% of all aortic aneurysms are mycotic and are mostly seen in the abd...Mycotic aortic aneurysms (MAAs) are infective aneurysms that are associated with catastrophic outcomes if not diagnosed and treated on time. Less than 3% of all aortic aneurysms are mycotic and are mostly seen in the abdominal aorta. , , and are the most common causative organisms for MAAs. species commonly cause infection in humans and occasionally result in serious complications, like mycotic aneurysms. , Typhimurium (serogroup B), Enteritidis (serogroup D), and Choleraesuis (serogroup C) are the most common strains found to be associated with MAA. We present the first case of mycotic aneurysm likely secondary to Kentucky infection.
Ali KB, Ncube F, Yahaya Y
… +2 more, Yakub YM, Magu MB
J Glob Infect Dis
· 2025 · PMID 41049252
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INTRODUCTION: Limited studies have investigated the seroprevalence of dengue viruses (DENVs) in Nigeria. Furthermore, there is no active surveillance program in place. Consequently, this study sought to determine the ser...INTRODUCTION: Limited studies have investigated the seroprevalence of dengue viruses (DENVs) in Nigeria. Furthermore, there is no active surveillance program in place. Consequently, this study sought to determine the seroprevalence of DENV in relevant studies published in all six geopolitical zones in Nigeria. METHODS: The scoping review was carried out using the Arksey and O'Malley framework. Twelve electronic databases were searched for relevant articles using a predesigned search strategy consisting of Mesh terms and Boolean search operators "AND" "OR." RESULTS: Out of a total of 2646 articles, 21 met the inclusion criteria. The results showed a high prevalence of dengue in Nigeria. The southeast and northwest zones had a prevalence of 70.8% and 64.8%, respectively. There was heterogeneity in the reviewed studies, in which enzyme-linked immunosorbent assay was used in 80%. Two studies used polymerase chain reaction and the detected serotypes were DENV 1 and DENV 2. The use of more than one laboratory method for the detection of DENV showed high sensitivity and specificity. CONCLUSION: Based on the above findings, it is deduced that dengue is hyperendemic in Nigeria, but there is no uniform data, only a few laboratory-backed seroprevalences are available in some parts of the country. Given this, it is advocated that there is a need for the public health authorities in Nigeria in collaboration with partners to establish a surveillance program to plan prevention and control efforts. It will also give evidence about the need to make vaccines available to especially those at higher risk.
J Glob Infect Dis
· 2025 · PMID 41049251
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INTRODUCTION: Sexually transmitted infections (STIs) affect approximately more than 1 million people around the world. Specific populations are more predisposed to diseases caused by poor access to health care, especiall...INTRODUCTION: Sexually transmitted infections (STIs) affect approximately more than 1 million people around the world. Specific populations are more predisposed to diseases caused by poor access to health care, especially sexual health. This is the case for Indigenous people and other traditional communities around the globe. This work aimed to evaluate the prevalence of some STIs in traditional quilombola communities in the northern region of Brazil. METHODS: A cross-sectional and prospective study was carried out from March 2021 to March 2022 of quilombola women from 5 communities. A questionnaire was applied to collect sociodemographic, behavioral, and clinical information. A gynecological examination was performed to collect cervical cells for oncotic cytology and to detect the agents through polymerase chain reaction analysis. RESULTS: Almost half of the women (48.3%) had at least one sexually transmitted agent. Human papillomavirus (HPV) was the most observed ( < 0.05). There were differences in the prevalence of STIs between the quilombola communities, and the type of women's profession was also influenced ( = 0.022 and = 0.027, respectively). Lower monthly income was associated with greater STI infection as well as the reproductive life cycle ( = 0.043 and = 0.026, respectively). Nonmenopausal women had a higher prevalence of STIs than those in menopause. CONCLUSIONS: Almost half of the quilombola women had at least one sexually transmitted agent. HPV infection was the most common. The location of the Quilombola community and women's profession was associated with the prevalence of STIs. Low monthly income and not being in menopause were associated with a higher prevalence of STIs.
Sood H, Anureet, Dhibar DP
… +5 more, Singh H, Suri V, Kumar R, Singh H, Bhalla A
J Glob Infect Dis
· 2025 · PMID 41049250
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F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been used previously for the diagnosis of sepsis of unknown focus and pyrexia of unknown origin. Its use in the diagnosis of pyom...F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been used previously for the diagnosis of sepsis of unknown focus and pyrexia of unknown origin. Its use in the diagnosis of pyomyositis has not been fully explored. Pyomyositis was found to be an important cause of sepsis, but its cause has not been fully elucidated in previous studies exploring the role of PET. We studied the role of whole-body F-FDG PET/CT in the diagnosis and management of 10 patients with suspected multifocal pyomyositis. In our study, we were able to find a distant focus in 7 out of 10 patients, which led to changes in treatment and outcome.
Patil BU, Ghongade P, Bhatkule M
… +1 more, Chavhan P
J Glob Infect Dis
· 2025 · PMID 41049249
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Peripheral blood smear examinations are routinely performed as the first investigation to diagnose malaria. Various malarial forms such as Schizonts, ring forms (trophozoites), and gametocytes are seen in the patient's p...Peripheral blood smear examinations are routinely performed as the first investigation to diagnose malaria. Various malarial forms such as Schizonts, ring forms (trophozoites), and gametocytes are seen in the patient's peripheral blood smears. Here, we report a sporadic case of a male patient in his early twenties who presented with dual infection with trophozoites and schizonts of , trophozoites of and multiple exflagellated microgametes of in the peripheral blood smear examination. Identifying the exflagellated form of is challenging due to its similarity with other hemoparasites. Exflagellation is very unusual during the developmental phase in the intermediate hosts such as humans, so exflagellated form should be reported correctly and promptly to receive appropriate treatment and prevent parasite transmission.
Balamurugan S, Mohan R, Mary JF
… +4 more, Sweta K, Thomas TRA, Selvamurthy S, Pasupathy S
J Glob Infect Dis
· 2025 · PMID 40727501
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INTRODUCTION: Scrub typhus is a vector-borne infection caused by the bacterium , transmitted to humans through the bite of larval forms of mites and hence called tsutsugamushi disease or rickettsial disease. The objecti...INTRODUCTION: Scrub typhus is a vector-borne infection caused by the bacterium , transmitted to humans through the bite of larval forms of mites and hence called tsutsugamushi disease or rickettsial disease. The objective of the study is to assess the disease severity, laboratory investigations, and complications of scrub typhus with the association of liver diseases and mortality rate of scrub typhus. METHODS: Data sources PubMed, Cochrane, and Google Scholar were systematically searched for data published up to May 2024. The studies selected were all scrub typhus patients associated with liver diseases. The data extraction was done as per the preestablished checklist. The mean difference for liver function test (LFT)'s aspartate aminotransferease and alanine aminotransferase level was analyzed, and risk difference was evaluated with liver disease and mortality rate using RevMan 5.4 software. Data analyses were performed from 2019 to 2024 (PROSPERO Registration: ID CRD42024515922). RESULTS: The analysis included a total of 901 scrub typhus cases with 554 cases associated with liver diseases. The study further investigated the LFT parameters, clinical symptoms, and 129 case mortality of scrub typhus. The meta-analyses showed that AST and ALT levels of scrub typhus patients had an overall significant effect in scrub typhus with liver disease (95% confidence interval [CI]: 135.81-153.15) with < 0.00001 and scrub typhus with liver disease and mortality rate (risk ratio: 4.29 [95% CI: 3.64-5.07], < 0.0001). A significant statistic -value indicates the presence of heterogeneity, as reflected by high I2 values (I2 = 96% and I2= 78%). CONCLUSION: 61.50% scrub typhus with liver disease patients and 14.32% mortality rate in scrub typhus were evaluated. This study demonstrated an association betweeen scrub typhus and liver disease, highlighting its severity and the mortality rate among hospitalized patients.
Das S, Mohapatra PR, Rath S
… +2 more, Bhuniya S, Mishra B
J Glob Infect Dis
· 2025 · PMID 40727500
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INTRODUCTION: The prevalence of nontuberculous mycobacteria (NTM) is on the rise worldwide. The diagnosis of NTM lung disease (NTM-LD) is a dilemma. The 2020 guidelines jointly established by the American Thoracic Societ...INTRODUCTION: The prevalence of nontuberculous mycobacteria (NTM) is on the rise worldwide. The diagnosis of NTM lung disease (NTM-LD) is a dilemma. The 2020 guidelines jointly established by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) outline the criteria for diagnosing pulmonary NTM disease. Herein, we report a series of cases with an analysis of relevant literature to gain insight into the pathogenicity of NTM species, the risk factors involved, and treatment strategies. METHODS: This is a prospective observational study starting from April 2023 to December 2023. A total of 370 suspected pulmonary tuberculosis (TB) patients were included. Clinical specimens were processed for Ziehl-Neelsen staining, GeneXpert (MTB)/RIF assay, and culture. Culture-positive mycobacteria were classified as MTB complex or NTM based on detection of MPT64 antigen. The NTM isolates were speciated by line probe assay using GenoType Mycobacterium common mycobacteria (Hain Lifescience, Nehren, Germany). The criteria of ATS/IDSA were applied to confirm NTM-LD. RESULTS: Nine ( = 9) patients were diagnosed as cases of NTM-LD. Bronchiectasis and previous TB were the most common comorbidities. ( = 2), ( = 2), ( = 1), ( = 1), ( = 1), ( = 1), and ( = 1) were the species involved. Specific therapeutic drug regimens were administered in four cases, which resulted in clinical improvement. CONCLUSION: People with comorbid (LDs) are at risk of NTM-LD. The severity of NTM-LD and mortality also depend on the species involved. New guidelines with evidence-based recommendations should be formulated to simplify the diagnosis and treatment of NTM-LD caused by an array of more than 190 species.
Mascio SD, Khadra F, Tchikladzé-Mérand C
… +2 more, Labroy S, Decambron M
J Glob Infect Dis
· 2025 · PMID 40727499
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INTRODUCTION: Electrophoresis of serum proteins (ESP) reveals the proteins present during the acute phase of a disease and enables the detection and monitoring of inflammatory syndrome. The aim of this study was to explo...INTRODUCTION: Electrophoresis of serum proteins (ESP) reveals the proteins present during the acute phase of a disease and enables the detection and monitoring of inflammatory syndrome. The aim of this study was to explore whether ESP could help to identify patients at risk of COVID-19 aggravation. METHODS: This was a two-center, observational, prospective study carried out between March 2021 and February 2022. Patients hospitalized in a COVID-19 unit, with an oxygen requirement of <6 L/min, were included. ESP was carried out every 4 days until clinical aggravation or discharge. Aggravation was defined by the requirement for >6 L/min oxygen, intensive care unit admission, or death. Risk factors for aggravation evaluated included age, comorbidities, serum proteins (albumin, globulins), % pulmonary damage (%PD) on computed tomography scans, D-dimers, C-reactive protein (CRP), ferritin, lymphocytes, and PO. Student's -test or Wilcoxon-Mann-Whitney test (quantitative variables) and Chi-square or Fisher's test (qualitative variables) were used for univariate analysis. Risk factors for COVID-19 aggravation were analyzed by logistic regression. The threshold of significance was 5%. RESULTS: A total of 161 patients were analyzed (mean [±standard deviation (SD)] age: 67.3 ± 16.6 years; 50.9% female). COVID-19 aggravated in 37 patients, within a mean (±SD) of 4.1 ± 2.6 days. In univariate analysis, α-1 globulins ( = 0.04), %PD ( = 0.02), and CRP ( = 0.02) at inclusion were significantly higher in patients whose disease aggravated. In multivariate analysis, %PD at inclusion was the only factor significantly linked to aggravation (OR = 2.3 [95% CI: 1.3‒4.7]; = 0.01). CONCLUSIONS: ESP was not predictive of clinical aggravation in hospitalized COVID-19 patients.
Alsahlawi A, Alkuwaiti M, Dhafer M
… +5 more, Alwazzeh M, Juraybi A, Alwarthan SM, AlQahtani S, Alwazzeh MJ
J Glob Infect Dis
· 2025 · PMID 40727498
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Miliary tuberculosis (MTB) is a disseminated form of tuberculosis (TB) arising from the lymphohematogenous dissemination of bacilli followed by millet seed-sized tuberculous foci. It mainly affects immunocompromised pat...Miliary tuberculosis (MTB) is a disseminated form of tuberculosis (TB) arising from the lymphohematogenous dissemination of bacilli followed by millet seed-sized tuberculous foci. It mainly affects immunocompromised patients and can lead to severe complications or even death. The clinical manifestation is diverse and depends on the organ affected, the patient's immune status, and the possible involvement of the central nervous system (CNS). Hence, this case report presents a case of an immunocompetent male with a decreased level of consciousness and convulsions requiring admission to the intensive care unit. The patient was diagnosed with MTB, meningoencephalitis, hydrocephalus, and severe hyponatremia. He subsequently improved after a short period of initiation of anti-TB medications. This report also highlights the clinical features of MTB and reviews the literature on associated CNS complications of MTB.
Bhardwaj SB, Chhibber S, Sood S
… +2 more, Mehta M, Sharma J
J Glob Infect Dis
· 2025 · PMID 40727497
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INTRODUCTION: is a Gram-positive facultative anaerobe bacteria now known to be implicated in periodontitis, tooth root infections, adimplantitis which are oral biofilm-mediated diseases. The ability of to form a biofil...INTRODUCTION: is a Gram-positive facultative anaerobe bacteria now known to be implicated in periodontitis, tooth root infections, adimplantitis which are oral biofilm-mediated diseases. The ability of to form a biofilm even as a mono-infection makes it more resistant to antibiotics. Bacteriophages are known to cure antibiotic-resistant bacterial infections. However, the main concern in phage formulations is the bacteriophage stability and loss of "antibacterial" activity. METHODS: In this study, a novel phage was isolated against 29212 from the sewage sample. The phage was propagated and identified using transmission electron microscope. Encapsulated phages were prepared using a biodegradable food grade chitosan-alginate coating shell suspended in honey-gelatin. The morphology of the chitosan-alginate microsphere was examined using scanning electron microscope (SEM) and pore size was determined by field emission gun-SEM. The encapsulated phages were checked for their lytic activity against host bacteria. The encapsulated bacteriophage was assayed for acid stability and thermal stability in simulated saliva. RESULTS: The phage isolated was lytic belonging to Siphoviridae family. The mean diameter of the chitosan-alginate microspheres was 1.7 ± 0.13 mm. The pore size of the phage-loaded chitosan-alginate shell was less than 100 nm, resulting in sustained release of the phages. The chitosan-alginate encapsulated phage was stable for a long time (6 h) in simulated saliva. The encapsulated phage could withstand exposure to different pH (pH 2, pH 4, and pH 7) in simulated saliva. It was also stable at different temperatures (4°C, 37°C, and 60°C). CONCLUSION: The encapsulated phage has the potential to be used as phage therapy in oral diseases. Further, the chitosan-alginate encapsulated phage microsphere can be incorporated in a patch/membrane/gel in combination with antibiotics/nutritional components/anti-inflammatory agents as treatment for oral diseases induced by .
J Glob Infect Dis
· 2025 · PMID 40727494
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Psittacosis is a zoonotic disease caused by the bacteria . It commonly presents with flu-like symptoms and community-acquired pneumonia (CAP). The bacteria is transmitted from birds to humans. The most common bird is par...Psittacosis is a zoonotic disease caused by the bacteria . It commonly presents with flu-like symptoms and community-acquired pneumonia (CAP). The bacteria is transmitted from birds to humans. The most common bird is parrots. Here, we present a cluster of cases of psittacosis in a family which led to the hospitalization of all the five members of the family. All the five patients presented with fever, weakness, dry cough, and dyspnea on exertion. immunoglobulin M was detected by indirect immunofluorescence assay. The family had a history of contact with parrots. The patients were treated with doxycycline and recovered without any complications. Psittacosis is an uncommon cause of CAP which can have a wide range of presentations, from being asymptomatic, to flu-like symptoms or to fulminant disease. Elaborate history and a high degree of suspicion are very important to come to the diagnosis. The infection is easily treatable with appropriate antibiotics. Public awareness and education regarding the zoonotic transmission of disease can reduce disease incidence.
J Glob Infect Dis
· 2025 · PMID 40727493
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INTRODUCTION: Neurological complications associated with the COVID-19 vaccine can include different neurological diseases. Although these cases are rare, it is crucial for healthcare professionals to recognize them for t...INTRODUCTION: Neurological complications associated with the COVID-19 vaccine can include different neurological diseases. Although these cases are rare, it is crucial for healthcare professionals to recognize them for timely diagnosis and treatment. The aim of this study was to analyze the impact, trend, and visibility of scientific publications on the neurological effects of the COVID-19 vaccine during 2020-2023 in Scopus. METHODS: A bibliometric, descriptive, and retrospective study was conducted. Through Scopus (SciVal), variables were measured objectively. Data were sought from December 2018 to August 2023. All papers on neurological effects associated with the COVID-19 vaccine were published between January 2020 and August 2023 in the Scopus database. On August 18, 2023, 65 articles were identified, of which 59 met the inclusion criteria. They were downloaded and exported in.csv format and subsequently analyzed in Microsoft Excel® 2019 using tables. RESULTS: The United States was the country with the highest number of authors (six) publishing on the subject in Scopus, followed by India with two authors. In addition, it was observed that the United States was the country with the highest production, with 30 publications and 411 countable citations. However, India, being the second in scientific production, was the country with the highest impact. Of the most productive institutions, six were from the United States, with Harvard University being the institution with the highest scientific production. With respect to the journals, six obtained two publications on the subject under study, where "" and "" stand out with 100 and 80 publications, respectively. CONCLUSIONS: The bibliometric analysis reveals that the USA leads in publications on adverse neurological effects of COVID-19 vaccine. India stands out for its impact, especially through institutions such as Ahmedabad Civil Hospital and B. J. Medical College. It is suggested to expand the research to other databases.
Samal J, Preetha GS, Kumar RP
… +3 more, Lakshman N, Dehury RK, Singh H
J Glob Infect Dis
· 2025 · PMID 40290207
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INTRODUCTION: The disastrous impact of the coronavirus disease 2019 (COVID-19) pandemic worldwide necessitated the prompt development of vaccines to combat the situation; however, vaccination drives have been challenged...INTRODUCTION: The disastrous impact of the coronavirus disease 2019 (COVID-19) pandemic worldwide necessitated the prompt development of vaccines to combat the situation; however, vaccination drives have been challenged by vaccine hesitancy among several communities across geographies. Understanding vaccine hesitancy and acceptance can help design appropriate vaccination strategies. With this background, a systematic review and meta-analysis were conducted to estimate the prevalence and assess the factors associated with vaccine hesitancy and acceptance among the Indian population. METHODS: This systematic review is reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The data were extracted from May 1, 2024, to May 30, 2024, using PubMed, Scopus, and DOAJ search engines. The keywords used in the search string are "COVID-19," "vaccine hesitancy," "vaccine acceptance," and "India." Finally, 26 articles were selected, and the included articles underwent a quality assessment with the help of the JBI-Checklist for cross-sectional studies. The pooled vaccine hesitancy and acceptance prevalence was estimated at a 95% confidence interval (CI) using a random effect model assuming potential heterogeneity. Analysis used Stata Now 18 SE (Stata Corp., College Station, TX, USA). RESULTS: Of the 26 studies, 14 studies were conducted among healthcare workers, seven studies among the general population, two studies among pregnant women and one each among school children, parents, and socioeconomically disadvantaged people. The reported highest vaccine acceptance was 92.74% and 86.3%, and hesitancy was 60.8% and 50% among healthcare workers and the general population, respectively. Between the general population and healthcare workers, the estimated pooled prevalence of vaccine acceptance is 66.1% (95% CI: 53%-78%) and 65.9% (95% CI: 57%-74%), respectively. The estimated pooled prevalence of vaccine hesitancy is 33% (95% CI: 20%-46%) among the general population and 24% (95% CI: 11%-40%) among healthcare workers. With the random effect model, high heterogeneity was observed in both acceptance ( >99%) and hesitancy ( >98%). CONCLUSION: A significant variation in the acceptability of the COVID-19 vaccine has been reported across different regions of India. Hence, future research is needed to enable comparability and generalizability, as the variations may also reflect differences in study designs, demographics, and time frames.