Asian Pacific Journal Of Cancer Prevention[JOURNAL]
Sun
200 papers
PIK3CA Polymorphisms in Cervical Cancer: Differential Impact of rs6443624 and rs141178472.
Srivastava H, Raghuvanshi S, Bhalla S … +8 more , Raghuvanshi S, Singh A, Singh AK, Singh N, Nigam N, Sonkar GK, Iqbal Z, Prakash S
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793685 · Publisher ↗
BACKGROUND: Cervical cancer remains a major cause of mortality in low- and middle-income settings. We assessed whether two PIK3CA single-nucleotide polymorphisms (SNPs) rs6443624 (A/C) and rs141178472 (C/T) are associate...
BACKGROUND: Cervical cancer remains a major cause of mortality in low- and middle-income settings. We assessed whether two PIK3CA single-nucleotide polymorphisms (SNPs) rs6443624 (A/C) and rs141178472 (C/T) are associated with disease risk, clinicopathological features, and survival. MATERIALS AND METHODS: In a prospective case control study at a tertiary center, 154 participants were enrolled (77 cases, 77 controls). Genomic DNA was isolated from FFPE cervical tumors (QIAamp DNA FFPE Tissue Kit) and genotyped using TaqMan allelic discrimination. Clinicopathological variables (FIGO stage, histology, grade, treatment, tumor-infiltrating lymphocytes [TILs]) were abstracted from records. Genotype distributions were compared by Pearson chi-square. Associations with clinicopathological features used chi-square/Fisher's exact as appropriate; ANOVA compared age across genotypes. Overall survival (OS) was estimated by Kaplan-Meier and compared with the log-rank test; mean OS with SE and 95% CI is reported. RESULTS: Cases were predominantly locally advanced at presentation and squamous histology; most were moderately differentiated. rs6443624 differed significantly between cases and controls (χ²=21.1, p<0.001), with CC over-represented in cases and CA less frequent. rs141178472 showed no significant case control difference (χ²=2.9, p=0.086). For OS, rs6443624 showed a significant genotype effect (log-rank χ²=23.45, p=0.001): AA had the poorest survival, CA the longest, CC intermediate. rs141178472 was not associated with OS (χ²=1.06, p=0.588). Genotype clinicopathological correlations for stage group, grade, TILs, and treatment were non-significant or inconsistent, with some comparisons limited by small sample sizes. CONCLUSION: The PIK3CA rs6443624 variant appears to influence both susceptibility and prognosis in cervical cancer, highlighting its potential as a biomarker for molecular risk stratification. Validation in larger, multi-center cohorts incorporating HPV/p16 assessment and extended follow-up is warranted to confirm its clinical relevance.
Association of ESRα-Pvull and ESRα-Xbal Polymorphisms with Breast Cancer Susceptibility in an Iranian Population: A Hospital-Based Case-Control Study.
Hashemzadeh-Charkhtab L, Kazemi M, Tavakoli N … +3 more , Abdolshahi S, Bozorgnia A, Gilasi H
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793684 · Publisher ↗
BACKGROUND: Genetic variations in estrogen receptor genes are implicated in the development of breast cancer (BC). Among these, the ESR1 PvuII and XbaI polymorphisms have been frequently evaluated, but findings remain in...
BACKGROUND: Genetic variations in estrogen receptor genes are implicated in the development of breast cancer (BC). Among these, the ESR1 PvuII and XbaI polymorphisms have been frequently evaluated, but findings remain inconsistent. This study aimed to examine the association of the PvuII and XbaI polymorphisms with breast cancer risk in an Iranian female population. MATERIALS AND METHODS: A case-control study was conducted on 100 breast cancer (BC) patients and 100 healthy, age-matched controls. Genotyping of the ESR1 PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G) polymorphisms was performed using PCR-RFLP, with results validated by direct DNA sequencing. Associations between genotypes, clinicopathological features, and disease risk were analyzed. RESULTS: Nominal differences in genotype distributions were observed. After applying multiple-testing correction across the pre-specified models, several associations remained statistically significant; however, marked deviations from Hardy-Weinberg equilibrium (HWE) in controls warrant cautious interpretation. CONCLUSION: Given the hospital-based design, small sample size, and significant deviations from HWE in controls, the observed ESR1 associations should be considered hypothesis-generating rather than confirmatory. Replication in larger, population-based Iranian cohorts with orthogonal genotyping approaches is required before any clinical implications are drawn.
Economic Evaluation of Fecal Occult Blood Test and Colonoscopy for Colorectal Cancer Screening in Indonesia: A Cost-Effectiveness Analysis.
Suardiana IK, Suardiani LAK, Yuliawati AN … +4 more , Endarti D, Phodha T, Wati NKS, Dewi NPNL
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793683 · Publisher ↗
OBJECTIVE: to evaluate the cost-effectiveness of Fecal Occult Blood Test (FOBT) and colonoscopy as Colorectal Cancer (CRC) screening methods in Indonesia. It is hoped that the results will serve as a reference for develo...
OBJECTIVE: to evaluate the cost-effectiveness of Fecal Occult Blood Test (FOBT) and colonoscopy as Colorectal Cancer (CRC) screening methods in Indonesia. It is hoped that the results will serve as a reference for developing an efficient and targeted early CRC screening policy. METHODS: A cost-effectiveness analysis comparing FOBT and colonoscopy for CRC screening in Indonesia was performed using a Markov model with a 40-year horizon. The analysis, from a healthcare payer perspective, included direct medical costs and QALYs. Parameters were sourced from literature and national data. Outcomes were lifetime costs, QALYs, and ICERs, with a willingness-to-pay threshold of three times GDP per capita. Costs and outcomes were discounted at 3%. Sensitivity analyses tested model uncertainty. Analyses were done using Microsoft® Excel. RESULT: CRC screening reduced both the incidence of colorectal cancer and CRC-related mortality compared to no screening. In terms of costs and outcomes, colonoscopy every 10 years produced the highest QALYs (2,114,459) and was the only strategy considered cost-effective compared to no screening, with an ICER of US$2,909.675/QALY, well below the willingness-to-pay threshold. While screening strategies incurred higher costs than no screening, colonoscopy was dominant when compared to both annual and biennial FOBT (ICERs: US$ -33,063.979/QALY and US$ -14,338.339/QALY, respectively). One-way sensitivity analysis identified cancer utility as key drivers of ICER variability. Probabilistic sensitivity analysis confirmed the robustness of the results, with the majority of simulations favoring colonoscopy as the most cost-effective option. CONCLUSION: Colonoscopy every 10 years is the most cost-effective strategy for colorectal cancer screening in Indonesia. It is cost-effective compared to no screening and dominant compared to annual or biennial FOBT.
Whole-Genome Analysis of Multidrug-Resistant Escherichia coli from Bloodstream Infections in Iraqi Cancer Patients.
Al-Jewari WM, Hassan BAR, Abdul Majeed AB … +4 more , Othman MF, Alsammarraie AZA, Al Qayyim MK, Alabboodi MK
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793682 · Publisher ↗
BACKGROUND: In Iraq, oncology patients with bloodstream infections face escalating treatment challenges due to rising antimicrobial resistance in Escherichia coli, compounded by limited diagnostic capacity and restricted...
BACKGROUND: In Iraq, oncology patients with bloodstream infections face escalating treatment challenges due to rising antimicrobial resistance in Escherichia coli, compounded by limited diagnostic capacity and restricted therapeutic options. However, data from oncology settings in Iraq are limited. This study aimed to characterize and compare the antimicrobial resistance gene profiles of multidrug-resistant and antibiotic-sensitive E. coli isolates from cancer patients, to inform infection control and stewardship strategies. METHODS: A prospective, multicenter investigation was conducted in three oncology hospitals in Baghdad. Fifty-five Escherichia coli bloodstream isolates, 36 multidrug-resistant (MDR) (65.5%) and 19 antibiotic-sensitive (34.5%), underwent phenotypic susceptibility testing using VITEK® 2 and disk diffusion. Whole-genome sequencing (Illumina MiSeq) was performed, and antimicrobial resistance genes (ARGs) were identified using AMRFinderPlus and classified by functional category. RESULTS: MDR isolates showed a broad resistome dominated by efflux systems. Across all isolates, a total of 36 unique antimicrobial resistance genes were identified, underscoring substantial resistome diversity., efflux pump genes were detected in 100%, β-lactamase genes in 88.9%, macrolide resistance genes in 66.7%, tetracycline resistance genes in 55.6%, and aminoglycoside resistance genes in 41.7%. Representative determinants included AcrAB-TolC/EmrAB-TolC/MdtABC-TolC (efflux) and BlaEC family/CMY-42/TEM types (β-lactams). Among sensitive isolates, only 11 antibiotic-associated genes, mainly efflux or regulators (e.g., acrF, emrD, emrR, emrY, tolC; regulators marR, evgA; target parC; others baeS, cpxA, cysB), overlapped with MDR, suggesting a shared core that is insufficient alone for phenotypic resistance without additional high-level mechanisms. CONCLUSIONS: Multidrug-resistant E. coli from oncology patients harbor dense, efflux-driven resistomes supplemented by diverse β-lactamases and other resistance determinants, while sensitive isolates retain a limited core set of genes. Genomic surveillance in cancer centers is critical for anticipating resistance emergence and informing targeted antimicrobial strategies.
Differential Clinical Outcomes of Palliative Radiotherapy among Different Molecular Subtypes of Metastatic Breast Cancer: A Prospective Study.
Thimmaiah N, Naveen N, Saini A … +4 more , Krishna U, Kannan M, Pasha T, Poojar S
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793681 · Publisher ↗
BACKGROUND: Molecular classification is used to tailor systemic therapy in breast cancer (BC). However, there is a paucity of literature correlating the response to radiotherapy with molecular subtypes of metastatic brea...
BACKGROUND: Molecular classification is used to tailor systemic therapy in breast cancer (BC). However, there is a paucity of literature correlating the response to radiotherapy with molecular subtypes of metastatic breast cancer (MBC) This prospective study intends to evaluate the differences in clinical outcomes in the different molecular subtypes of MBC to hypofractionated palliative radiotherapy (HPRT). METHODS: MBC patients between December 2021 to September 2022, with Karnofsky Performance status > 70, were enrolled and treated with HPRT. All patients received systemic therapy. All patients were evaluated until 12 months post-radiotherapy. The molecular subtype of BC, local control (LC), and progression-free survival (PFS) were documented. RESULT: Eighty patients were recruited, with a mean age of 51 ± 10.48 years. Twelve of 80 patients expired, and 16 of 80 patients were lost to follow-up. The molecular subtypes were: Luminal B (37.5%), Luminal A (30%), TNBC (20%) and HER2+ (12.5%). At 6 months post-RT, 61.5% patients had local control (LC) at their metastatic site, whereas 38.5% had Progressive disease (PD). At 12 months, 71.1% had LC at the metastatic site, and 28.9% had progression. Local control at 6 months by subtype: Luminal A - 83%, Luminal B - 60%, HER2+ - 50% and TNBC - 31.2% (p = 0.01). The median progression-free survival (PFS) of the study group was 6 months (95% CI: 4.78-7.22), with TNBC patients performing the poorest. CONCLUSION: Luminal subtypes have better local control and progression-free survival post-HPRT compared to TNBC and HER2+ subtypes, which can further be used to stratify radiotherapy fractionation schedules.
Quinoxaline as Dual Modulators of Apoptotic Regulators Bcl-2 and Bax: A Combined In Vitro and In Silico Anticancer Approach.
Meshak Dhanashekaran CJ, Venugopal VP, Chokkalingam N … +2 more , Sakthivel KM, Narayanaswamy R
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793680 · Publisher ↗
OBJECTIVE: This study aimed to evaluate the antioxidant potential of quinoxaline and investigate its molecular interactions with cancer-related proteins through computational docking. METHODS: Antioxidant activity of qui...
OBJECTIVE: This study aimed to evaluate the antioxidant potential of quinoxaline and investigate its molecular interactions with cancer-related proteins through computational docking. METHODS: Antioxidant activity of quinoxaline was assessed using DPPH, FRAP, ABTS, hydrogen peroxide, superoxide, and reducing power assays at varying concentrations, and IC₅₀ values were calculated. Molecular docking studies were performed to examine the interactions of quinoxaline with cancer-associated proteins, including epidermal growth factor receptor (EGFR), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and β-actin. RESULTS: Antioxidant assays showed a concentration-dependent increase in inhibitory activity, with IC₅₀ values of 130.446 µM (DPPH), 151.343 µM (FRAP), 171.551 µM (ABTS), 108.194 µM (H₂O₂), 104.592 µM (superoxide), and 95.893 µM (reducing power assay). Molecular docking analysis revealed that quinoxaline exhibited strong binding affinity with the anti-apoptotic Bcl-2, suggesting potential inhibition of its function. Additionally, favorable interactions with the pro-apoptotic Bax were observed, indicating a possible dual mechanism of apoptosis induction. CONCLUSION: Quinoxaline demonstrated significant antioxidant activity and potential pro-apoptotic effects by targeting key apoptotic regulators. The docking results suggest that quinoxaline could inhibit anti-apoptotic Bcl-2 while promoting the activity of the pro-apoptotic Bax, thereby inducing apoptosis and highlighting its potential as a promising anticancer agent.
Effect of Nurse-led Intervention on Shoulder Dysfunction among Breast Cancer Patients Undergoing Modified Radical Mastectomy (MRM), South India: A Randomized Controlled Trial.
S AN, Mj K, Dubashi B … +2 more , Tp E, Ramamoorthy L
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793679 · Publisher ↗
BACKGROUND: Breast cancer can strike women at any age after puberty, though its incidence increases with age. The WHO's Global Breast Cancer Initiative (GBCI), between 2020 and 2040, aims to prevent 2.5 million breast ca...
BACKGROUND: Breast cancer can strike women at any age after puberty, though its incidence increases with age. The WHO's Global Breast Cancer Initiative (GBCI), between 2020 and 2040, aims to prevent 2.5 million breast cancer deaths globally. This study aimed to assess the effect of a nurse-led intervention on shoulder dysfunction among breast cancer patients undergoing modified radical mastectomy (MRM) - a randomized controlled trial. METHODS: A total of 320 breast cancer patients undergoing MRM (Study group-160, Control group-160) who met the inclusion criteria were included in the study. Block randomization was used to allot participants to both groups through a computer-generated random sequence. The experimental group received a nurse-led intervention in addition to routine care, while the control group received routine care only. Shoulder range of motion (ROM) was measured using a goniometer at baseline and at every 3-month interval up to 1 year. Disability of the Arm, Shoulder, and Hand (DASH) was assessed at 6th and 12th month follow-ups using the DASH questionnaire. RESULTS: Overtime comparison of shoulder ROM shows the significant effect of time, group, and a significant time × group interaction (p < 0.001), indicating that the flexion, extension, abduction, internal rotation, and external rotation angles improved significantly over time, and that the pattern of improvement differed between the intervention and control groups. During the 3rd and 6th month follow-up, Grade II loss of shoulder ROM was observed in one patient (0.68%) in the experimental group, whereas in the control group, it was observed in 25 patients (16.89%) and 18 patients (12.41%), respectively. DASH scores during the 6th and 12th month follow-up were 6 (3.06-10.25) and 5.17 (1.72-8.62) in the experimental group, whereas in the control group, they were 21.5 (14.25-34.25) and 24.14 (15.52-35.34) (p <0.001). CONCLUSION: In this study, early intervention and consistent motivation and reinforcement helped in preventing or reducing shoulder dysfunction, thereby reducing disability and enhancing quality of life (QOL).
Cost Disparities Between Hospital Expenditures and Reimbursement Schemes in Indonesia: A Study on Chemotherapy for Breast Cancer.
Kurniawan MD, Abdissalam E, Ariawan MW … +3 more , Rahem A, Yulistiani Y, Wigatiningtyas A
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793678 · Publisher ↗
OBJECTIVE: Significant gaps exist between hospital-incurred medical costs and national health insurance reimbursement rates, challenging the sustainability and equity of breast cancer care in Indonesia. Fixed tariffs oft...
OBJECTIVE: Significant gaps exist between hospital-incurred medical costs and national health insurance reimbursement rates, challenging the sustainability and equity of breast cancer care in Indonesia. Fixed tariffs often fail to capture the complexities and financial burdens associated with chemotherapy. This study compares hospital-incurred medical costs with both INA-CBG and non-INA-CBG reimbursement rates for breast cancer chemotherapy, identifies the key cost components, and evaluates the appropriateness of current tariffs under the National Health Insurance (JKN) scheme. METHODS: A retrospective cross-sectional study was conducted at a tertiary hospital in Surabaya, Indonesia, using data from breast cancer patients who underwent chemotherapy in 2021. Clinical and cost data were obtained from hospital billing records, electronic medical records, and BPJS Kesehatan claims. The Wilcoxon signed-rank test was used to compare hospital-incurred medical costs with reimbursement rates. Subgroup analyses by INA-CBG code and chemotherapy regimen were performed to assess variability in coverage. RESULTS: A total of 80 patients were included, predominantly female (97.5%) and diagnosed with stage IV disease (64.1%). Most were categorized under INA-CBG code C-3-13-0 (93.75%). Overall, the median hospital-incurred medical costs significantly exceeded reimbursement rates: IDR 3,657,290 vs. IDR 1,161,000 for C-3-13-0 (p < 0.001) and IDR 3,964,189 vs. IDR 2,151,900 for C-4-13-I (p = 0.031). Key cost drivers were chemotherapy administration (57.93%), nursing care (14.04%), and handling of cytotoxic drugs (7.88%). Specific regimens, such as vinorelbine, showed significantly higher costs that were not adequately reimbursed. CONCLUSION: JKN tariffs for breast cancer chemotherapy substantially underestimate actual treatment costs. To improve financial sustainability and access, periodic tariff adjustments, adoption of activity-based costing, and consideration of hybrid payment models should be implemented to ensure equitable financing of oncology care in Indonesia.
Quality of Recovery Following Lobectomy for Lung Cancer under the Enhanced Recovery After Surgery (ERAS) Program: A Single-Center, Cross-Sectional Study in Vietnam.
Cuong LT, Bang HT, Hung HQ … +4 more , Vy TT, Tuan LQA, Vu PTN, Tap NV
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793677 · Publisher ↗
BACKGROUND: The Enhanced Recovery After Surgery (ERAS) protocol aims to achieve early recovery. However, its effects on the quality of recovery (QoR), as measured by patient-reported outcomes, still require further evalu...
BACKGROUND: The Enhanced Recovery After Surgery (ERAS) protocol aims to achieve early recovery. However, its effects on the quality of recovery (QoR), as measured by patient-reported outcomes, still require further evaluation. This study aims to assess the QoR in patients undergoing lobectomy under ERAS protocol and identify the factors influencing QoR. METHODS: A cross-sectional study was conducted using the QoR-15 score to measure QoR. The implementation of its twenty-seven components measured ERAS protocol adherence. Descriptive statistics were applied to describe the characteristics of QoR. Correlation and multivariable regression analyses assessed associations between ERAS adherence and QoR-15. Structural equation modeling (SEM) was used to evaluate whether potential factors mediated the ERAS adherence and QoR relationship via the average causal mediation effect (ACME). RESULTS: This study included 98 patients. Their median QoR-15 score was 133, with an interquartile range of 130 to 134. QoR was excellent in 9.2%, good in 85.7%, and moderate in 5.1% of patients. The QoR-15 score moderately correlated with pain severity within the first 24 hours postoperatively (at POD0; ρ=-0.43, p<0.001) and ERAS adherence levels (ρ=0.31, p=0.002). Multivariable linear regression showed that pain at POD0 independently affected QoR-15 scores (β=-0.296, 95% confidence interval [CI] -0.407 to -0.184, p<0.001), while overall ERAS adherence did not (β=0.288, 95% CI -0.293 to 0.868, p=0.327). SEM analysis confirmed that higher ERAS adherence significantly reduced pain severity at POD0 (β = -0.47 per additional factor adhered to, p < 0.001), which in turn improved QoR-15 scores via a significant indirect effect (ACME = 0.381, p = 0.016). CONCLUSIONS: Patients undergoing lobectomy under the ERAS protocol generally report positive QoR experiences. Adherence to the ERAS protocol may indirectly enhance QoR by reducing early postoperative pain. The study shows favorable QoR outcomes with ERAS implementation and highlights the importance of protocol adherence.
Disruption of EMT Signaling and Migration by Moringa oleifera Leaf Powder-Silver Nanoparticles (MOLP-AgNPs) in HeLa Cervical Cancer Cells.
Fatiha RA, Ngabdi CK, Azizah JS … +6 more , Putri BSN, Lestari B, Malek NANN, Susanto H, Riawan W, Permatasari HK
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793676 · Publisher ↗
OBJECTIVE: This study aimed to evaluate the potential anticancer effect of Moringa oleifera leaf powder-silver nanoparticles (MOLP-AgNPs) by assessing their impact on epithelial-mesenchymal transition (EMT) markers and c...
OBJECTIVE: This study aimed to evaluate the potential anticancer effect of Moringa oleifera leaf powder-silver nanoparticles (MOLP-AgNPs) by assessing their impact on epithelial-mesenchymal transition (EMT) markers and cell migration in HeLa cervical cancer cells. METHODS: HeLa cells were treated with MOLP-AgNPs at concentrations of 2, 4, and 6 µg/mL, alongside an untreated control group. Cell viability was assessed using the trypan blue exclusion method to determine non-toxic concentrations. A scratch (wound-healing) assay was used to evaluate cell migration, while immunofluorescence staining was performed to detect the expression of EMT-related proteins Snail and vimentin. RESULT: MOLP-AgNPs significantly inhibited cell migration in a dose-dependent manner (p < 0.05). Additionally, the expression of Snail and vimentin was markedly downregulated following treatment, indicating suppression of EMT-related pathways (p < 0.001). CONCLUSION: These exploratory preclinical findings suggest that MOLP-AgNPs exert anti-migratory effects on cervical cancer cells by modulating EMT. Although HeLa is a non-metastatic cell line, this study highlights the potential of MOLP-AgNPs as a promising candidate for further investigation in metastatic cancer models.
Dysregulated TMPO-AS1/let-7b-5p/PLK1/E2F1 Axis Associated with Poor Prognosis in Lung Adenocarcinoma.
Baweja B, Vats P, Saini C … +1 more , Nema R
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793675 · Publisher ↗
OBJECTIVES: This study examines the regulatory mechanisms underlying PLK1 overexpression in lung adenocarcinoma, especially in smokers. It focuses on understanding the ceRNA network, including mRNAs, miRNAs, and lncRNAs,...
OBJECTIVES: This study examines the regulatory mechanisms underlying PLK1 overexpression in lung adenocarcinoma, especially in smokers. It focuses on understanding the ceRNA network, including mRNAs, miRNAs, and lncRNAs, while also identifying potential prognostic biomarkers. METHODS: Publicly available databases, including Oncomine, TIMER 2.0, UALCAN, OncoMX, GEPIA2, OncoDB, ENCORI, KM Plotter, CellTracer, miRNet, CancerMIRNome, and Enrichr, were extensively utilized to assess the expression profile, prognostic significance, and regulatory interactions of PLK1 in lung adenocarcinoma (LUAD) and normal tissues. RESULTS: PLK1 expression is significantly elevated in lung adenocarcinoma (LUAD), with a hazard ratio of 1.95, indicating a correlation with poor overall survival. Among patients who smoke, elevated PLK1 expression is associated with a higher hazard ratio of 1.64 and reduced survivability. The transcription factor E2F1 has been identified as a potential regulator of PLK1 expression in LUAD. Additionally, the microRNA hsa-let-7b-5p shows a negative correlation with both E2F1 and PLK1, while the long non-coding RNA TMPO-AS1 is positively associated with the E2F1/PLK1 axis. These findings suggest a regulatory cascade where TMPO-AS1 may function as a molecular sponge for hsa-let-7b-5p, thereby enhancing E2F1-mediated PLK1 expression and promoting the progression of LUAD. CONCLUSION: The study highlights the PLK1/E2F1/hsa-let-7b-5p/TMPO-AS1 regulatory axis as a key contributor to aggressive LUAD. Targeting this ceRNA network either by inhibiting TMPO-AS1 or restoring hsa-let-7b-5p activity may offer a promising strategy for therapeutic intervention in smoking-associated LUAD.
Metabolite Profiling and Network Pharmacology of Persimmon Vinegar (Diospyros kaki) Compounds, with in silico Validation for Non-Small Cell Lung Cancer Therapy.
Mutiah R, Rachmawati E, Taufik I … +4 more , Milliana A, Ambar Sari R, Rahmadani N, Fitriyani F
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793674 · Publisher ↗
OBJECTIVE: Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer, with complex mechanisms, drug resistance, and significant side effects from conventional chemotherapy, all of which hinder effectiv...
OBJECTIVE: Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer, with complex mechanisms, drug resistance, and significant side effects from conventional chemotherapy, all of which hinder effective treatment. Diospyros kaki (persimmon) vinegar, produced through spontaneous fermentation, has enhanced flavonoid content that may increase its pharmacological activity; however, its molecular mechanisms against NSCLC remain unclear. This is the first study to map the molecular mechanisms of persimmon vinegar compounds against NSCLC by integrating metabolite profiling, network pharmacology, and molecular docking validation. METHODS: Compounds were identified using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and screened for pharmacological properties, followed by network pharmacology and molecular docking to explore potential targets against NSCLC. RESULT: Twenty-two compounds were identified, with three key compounds benzoyl arginine amine, indoline, and exocarpic acid, implicated in the NSCLC pathway (hsa05223). Twenty-seven target genes were associated with this pathway. Benzoyl arginine amine exhibited a binding affinity of -86.9707 kcal/mol for CDK6 (PDB ID: 8I0M) and -120.017 kcal/mol for HRAS (PDB ID: 3K8Y), greater than their native ligand, suggesting its potential to inhibit CDK6 activity, block the G1/S phase transition, and suppress cancer cell proliferation via the E2F pathway. Its interaction with HRAS may inhibit the MAPK pathway, which is critical for cancer progression. CONCLUSION: These findings provide preliminary evidence for the potential of persimmon vinegar compounds as leads for NSCLC drug development, warranting further in vitro and in vivo studies.
Breast Cancer Screening in Tunisia: A Cross-Sectional Study on Women's Knowledge, Attitudes and Practices.
Ben Youssef F, Skhiri A, Ayedi Y … +2 more , Harizi C, Fakhfakh R
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793673 · Publisher ↗
INTRODUCTION: In Tunisia, the incidence and mortality rates of breast cancer are relatively high and are projected to remain a significant health burden by 2030. We aimed to evaluate the knowledge, attitudes, and practic...
INTRODUCTION: In Tunisia, the incidence and mortality rates of breast cancer are relatively high and are projected to remain a significant health burden by 2030. We aimed to evaluate the knowledge, attitudes, and practices of Tunisian women regarding breast cancer screening and to determine the factors associated with good practice using multivariable regression. METHODS: We conducted a cross-sectional descriptive study among adult female Tunisian population for 10 days period (from 6 till 16 October 2022), using an online self-administered survey. We assessed knowledge related to breast cancer and screening methods, screening practices and attitudes towards breast cancer screening. Good knowledge, good attitude and good practices were defined as achieving ≥75% correct answers. RESULTS: In total of 183 females were included (Mean age 33.7±8.2[18 - 64]). Almost all participants (96.7%, n= 177) lived in urban areas and 74.3% (n=136) were married. One-third of the participants were housewives (33.9%, n=62) and 83.6% (n=153) had an academic education. One participant (0.5%) had a personal history of breast cancer, while 26.2% (n=48) reported a family history of breast cancer. Among the participants, 42.6% (n=78) demonstrated good knowledge, 88.5% (n=162) had a good attitude score, and 21.3% (n=39) achieved a good practice score. Good practice was associated with good knowledge (Adjusted OR= 5.0, 95%CI [2.2-11.2],p<0.01), age ≥35 years (Adjusted OR= 2.5, 95% CI [1.1-5.4], p=0.02) and a family history of breast cancer (Adjusted OR= 2.2, 95% CI [1.0-5.1], p=0.04). CONCLUSION: Our study showed a moderate knowledge and practice regarding breast cancer screening, alongside a generally good attitude. The factors associated with good practice underscore the importance of educational interventions and the targeted screening strategies.
Translation and Validation of the Neurologic Assessment in Neuro-Oncology Scale into Indonesian (NANO-Ina).
Angelita MC, Andini PW, Andriani R … +3 more , Sofyan HR, Savitri I, Aninditha T
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793672 · Publisher ↗
OBJECTIVE: Assessment of treatment efficacy in neuro-oncology is measured by radiographic criteria. This can be misleading, as imaging findings may not translate into clinical benefit. The NANO scale, constructed by mult...
OBJECTIVE: Assessment of treatment efficacy in neuro-oncology is measured by radiographic criteria. This can be misleading, as imaging findings may not translate into clinical benefit. The NANO scale, constructed by multidisciplinary experts, is an objective and measurable metric of neurological function that can be evaluated during routine examinations in brain tumor patients, so that patients receive an overall assessment of progression, along with radiological findings. This study aims to determine the validity and reliability of the Indonesian version of the NANO scale (NANO-Ina). METHODS: The study was performed at Cipto Mangunkusumo National Referral Hospital, Jakarta. The validity and reliability process incorporated forward and backward translation to ensure cross-cultural equivalence, and an initial trial was conducted with 10 physicians to identify potential issues and refine item clarity. Subsequently, the 9 domains of the NANO-INA version were tested on 30 pathologically confirmed brain tumor patients by 2 distinct physicians separately. Inter-rater reliability was analyzed using the Kappa statistics. RESULT: A total of 30 subjects were enrolled from January to August 2023, which included subjects mostly diagnosed with brain metastasis (30%), and the rest were equally distributed among meningioma, glioblastoma, and other primary brain tumors (23.3%). Among these, the majority had not received any treatment (77%), and the remaining were on chemoradiation (10%), chemotherapy (10%), and radiation (3.3%). Our inter-observer variability study demonstrated that the NANO-INA scale exhibits substantial to almost perfect agreement (kappa statistic ranging from 0.629-0.935) for all domains (p<0.05), with the highest agreement observed in strength, facial strength, and language. CONCLUSION: The NANO-INA scale shows a high level of inter-observer agreement and serves as a reliable tool for assessing neurological function in patients with brain tumors in clinical settings in Indonesia.
The Predictors of Liver Fluke Infection-Preventive Behaviors, Khon Kaen Province: A Structural Equation Model.
Rattaporn W, Sillabutra J, Kitidamrongsuk P … +2 more , Kamsa-Ard S, Satitvipawee P
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793671 · Publisher ↗
BACKGROUND: Liver fluke infection is a public health problem and the main cause of cholangiocarcinoma in northeastern Thailand, especially in Khon Kaen Province. This study aimed to determine the prevalence and predictor...
BACKGROUND: Liver fluke infection is a public health problem and the main cause of cholangiocarcinoma in northeastern Thailand, especially in Khon Kaen Province. This study aimed to determine the prevalence and predictors of liver fluke infection-preventive behaviors, using the Health Belief Model (HBM) and Structural Equation Modeling (SEM) among adults living in Khon Kaen Province. METHODS: This analytical cross-sectional study utilized secondary data. A stratified cluster multi-stage sampling technique, proportional to size, was used to select a provincially representative sample of the Khon Kaen adult population. The participants responded via interview. HBM scale, demographic and environmental factors, knowledge, health behaviors, and information on preventive behaviors (avoidance of consuming various types of uncooked freshwater fish and five personal hygiene practices) were measured. The hypothesized causal path models were examined using SEM analysis. RESULTS: Among the 980 adult participants, the prevalence of non-consumption of raw freshwater fish and the practice of good hygiene during the past month was 2.9% (95% CI: 2.0, 4.1). The final structural model demonstrated a good fit. The predictors explained 25.7% of the variance in preventive behaviors. The model indicated that the total effect of perceived susceptibility had the strongest correlation with liver fluke infection-preventive behaviors (β = 0.34, p < 0.001), followed by perceived severity (β = 0.31, p < 0.001), having a family member who did not consume raw fish (β = 0.27, p < 0.001), education (β = 0.14, p < 0.001), self-efficacy (β = 0.13, p < 0.001), perceived benefit (β = 0.13, p < 0.001), knowledge (β = 0.10, p < 0.001), non-smoking (β = 0.09, p < 0.05), age (β = -0.08, p < 0.05), cue to action (β = 0.06, p < 0.05), and perceived barriers (β = -0.05, p < 0.05). CONCLUSION: Our study showed that significant predictors of preventive behaviors included the HBM constructs, age, education, knowledge, non-smoking, and living with family members who do not consume raw fish. Public health campaigns should focus on strengthening HBM constructs and knowledge with particular attention to older adults, smokers, less-educated individuals, and households in which family members consume raw fish.
Cytogenetic Profile of Newly Diagnosed Acute Myeloid Leukemia Patients: Insights from a Study at a Tertiary Care Centre in South India.
Padmakumar D, Radhakrishnan Chandraprabha V, Mohanan Nair JKK … +7 more , Thampirajan Vimala Devi AR, John Anitha GR, Mohanan Sreelatha M, Padmakumar A, Lathika Surendran S, Narayanan G, Sreedharan H
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793670 · Publisher ↗
PURPOSE: Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy characterized by a wide range of cytogenetic abnormalities that have critical diagnostic and prognostic implications. South Indian populatio...
PURPOSE: Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy characterized by a wide range of cytogenetic abnormalities that have critical diagnostic and prognostic implications. South Indian populations are underrepresented in global AML research, warranting region-specific cytogenetic profiling. METHODS: We performed a cytogenetic analysis of 400 newly diagnosed adult AML patients at a tertiary care center in South India. Conventional karyotyping and fluorescence in situ hybridization (FISH) were performed, and findings were correlated with clinical parameters according to the 2016 WHO and FAB classifications. RESULTS: Abnormal karyotypes were observed in 49.5% of cases, while 50.5% showed normal karyotypes. The most frequent abnormalities were t(15;17) (16.2%), t(8;21) (6.7%), and inv(16) (3.7%). Other notable findings included trisomy 8 (1.7%), trisomy 21 (1%), and complex karyotypes (6.5%). AML-M4 (33.5%) was the most common FAB subtype. Significant associations were noted between cytogenetic risk groups and variables such as age, gender, and white blood cell count. The distribution of cytogenetic aberrations revealed both similarities and distinct differences when compared with global data, reflecting ethnic and geographical influences. CONCLUSION: This study highlights the cytogenetic diversity of AML in a South Indian cohort and confirms the importance of cytogenetic analysis in disease classification, risk stratification, and therapeutic decision-making. The findings underscore the need for regional data to refine AML diagnosis and optimize management strategies across different populations.
Diagnostic Value of Rabbit-Derived 47 kDa Epitope-Based Antibodies as a Detection and Evaluation Method for Bladder Cancer.
Nur Budaya T, Seputra KP, Susianti H … +3 more , Aditya Hutama S, Wilianto B, Amanda C
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793669 · Publisher ↗
OBJECTIVE: This study aims to generate polyclonal antibodies against the 47 kDa protein using rabbits, and to evaluate both the diagnostic and prognostic potential of this biomarker in patients with bladder cancer. METHO...
OBJECTIVE: This study aims to generate polyclonal antibodies against the 47 kDa protein using rabbits, and to evaluate both the diagnostic and prognostic potential of this biomarker in patients with bladder cancer. METHODS: Rabbits were immunized intraperitoneally with epitope antigens of the 47 kDa protein over a period of four weeks. Serum was collected in the fifth week five for antibody isolation. The resulting polyclonal antibodies were employed to detect urinary biomarkers in patients with bladder cancer. Additionally, these antibodies were used to evaluate therapeutic response in patients undergoing trimodal therapy, based on the RECIST (Response Evaluation Criteria in Solid Tumors) criteria, using the dot blot technique. RESULTS: The highest density value with the best dilution effectiveness of 18.27 was found at antibody dilution 1/105 and antigen 1/106. From the dot blot analysis, this study found that the sensitivity and specificity of this antibody are 98.7% and 100%, respectively. The 47 kDa protein showed a high significant difference between each cancer stage before and after chemotherapy (PD: 7.91±1.99; SD: -1.00±0.83, PR: -5.80±3.21 CR: -7.95±1.47; p= 0.000), with a negative correlation with RECIST Criteria (r: -0.833, p=0.000). CONCLUSION: The 47 kDa protein demonstrates strong diagnostic performance and may be utilized as a prognostic factor in bladder cancer patients who have undergone trimodal therapy.
Pattern of Somatic Mutations in the PIK3CA Oncogene and Their Role as a Potential Prognostic Biomarker in Breast Cancer Patients in Sri Lanka: A Pilot Study.
Cabraal TR, Kumarasinghe I, Perera R … +4 more , Balawardana J, Viswakula S, Perera N, Galhena GH
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793668 · Publisher ↗
BACKGROUND: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit-alpha (PIK3CA) oncogene is one of the most frequently mutated oncogenes in breast cancer, with mutations influencing prognosis and therapeutic...
BACKGROUND: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit-alpha (PIK3CA) oncogene is one of the most frequently mutated oncogenes in breast cancer, with mutations influencing prognosis and therapeutic response. This study aimed to determine the pattern of hotspot PIK3CA mutations and assess their association with clinicopathological parameters and relapse-free survival (RFS) among Sri Lankan breast cancer patients. MATERIALS & METHODS: A qPCR-based genetic analysis was performed on DNA from formalin-fixed, paraffin-embedded (FFPE) tissue samples of 63 clinically diagnosed female Sri Lankan breast cancer patients, using the QClamp® PIK3CA Mutation Detection Test to detect hotspot mutations in PIK3CA (i.e., H1047R, E545K, E542K), followed by statistical analysis. Patient samples and clinical data were fully anonymized, with no identifying information available to the authors at any point during the study. RESULTS: Somatic missense PIK3CA mutations H1047R and E542K were detected in 17.46% of the cohort. The E545K mutation was not detected. The observed mutations were associated with an increased risk of lymph node (LN) metastasis (p=0.036, OR 9.60) and reduced recurrence-free survival (RFS) (p<0.001, HR 26.19). Patients with a high Ki67 index (p=0.029, HR 79.69) and LN-positive status (p=0.026, HR 123.94) also showed worse outcomes. In addition, the combination of all three factors- presence of a PIK3CA mutation, LN metastasis, and a high Ki67 index- was associated with reduced RFS (p<0.001). CONCLUSION: Despite being a pilot study, the findings indicate that PIK3CA mutations are associated with adverse prognostic outcomes in Sri Lankan breast cancer patients. These results demonstrate the potential utility of PIK3CA testing and PI3K-targeted therapy in clinical management in Sri Lankan, pending validation in larger cohorts.
Meta-Merging the Transcriptomes of Gastric Tumors Redefines the Connections among Molecular and Clinical Subtypes.
Sekar BT, Ganesan K
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793667 · Publisher ↗
INTRODUCTION: The availability of a large number of cancer expression profiles presents an excellent opportunity to re-investigate various biological and clinical questions. While several expression profiles have been es...
INTRODUCTION: The availability of a large number of cancer expression profiles presents an excellent opportunity to re-investigate various biological and clinical questions. While several expression profiles have been established for different cancers, merging them may provide a more powerful platform for extensively extrapolating molecular and clinical features across multiple cohorts. MATERIALS AND METHODS: In this study, five gastric tumor expression profiles from the Gene Expression Omnibus [GEO] and one in-house cohort comprising a total of 1,060 samples were merged. The batch effect was removed using non-parametric ComBat analysis, and the seamless merging of datasets was confirmed through various parameters. RESULTS: Extrapolation of ACRG [Asian Cancer Research Group] and TCGA [The Cancer Genome Atlas] molecular subtypes in the merged cohort of 1,060 gastric tumors revealed nine distinct clusters. Notably, the following patterns were observed: [i] mutual exclusivity between Epithelial to Mesenchymal Transition [EMT] and Microsatellite Instability [MSI] subtypes in 90% of tumors; [ii] overlapping occurrence of EMT and MSI subtypes in the remaining tumors; [iii] overlap between MSI and Epstein-Barr Virus [EBV] subtype tumors; [iv] both commonalities and differences between EMT and Genomically Stable [GS] subtypes; and [v] an association between EBV positivity and PI3K mutation. CONCLUSION: The current study demonstrates that compiling a larger expression profile is valuable for revisiting the molecular features and epidemiology associated with molecular subtypes, thereby aiding in the development of novel diagnostics and targeted therapeutics.
The Impact of the Indonesian National Health Insurance Implementation on Prostate Cancer Detection, Staging, and Treatment in West Java Province, Indonesia.
Sihombing AT, Kartika A, Hengky A
Asian Pac J Cancer Prev · 2026 Mar · PMID 41793666 · Publisher ↗
BACKGROUND: This study aimed to evaluate the impact of National Health Insurance/ Jaminan Kesehatan Nasional (JKN) implementation on prostate cancer detection, staging, and treatment in West Java Province, Indonesia, wit...
BACKGROUND: This study aimed to evaluate the impact of National Health Insurance/ Jaminan Kesehatan Nasional (JKN) implementation on prostate cancer detection, staging, and treatment in West Java Province, Indonesia, with a focus on changes in prostate-specific antigen (PSA) testing accessibility. METHODS: This cross-sectional study retrospectively analyzed medical records from Hasan Sadikin Hospital, a tertiary referral center, to compare prostate cancer cases between 2009-2013 (pre-JKN) and 2015-2019 (post-JKN). Data included age at diagnosis, PSA levels, Gleason grade, T and M stages, and treatment modalities. Additionally, a survey of urologists in West Java was conducted to assess PSA testing practices and JKN coverage. Statistical analyses were performed using Chi-square and Mann-Whitney U-tests. RESULTS: Following JKN implementation, a significant increase in median PSA levels (from 29.275 ng/ml to 85.845 ng/ml, p=0.002) was observed. This was accompanied by a shift towards higher Gleason grade groups (p<0.001), more advanced T stages (p<0.001), and advanced M stages (p=0.003). The survey revealed limited PSA testing coverage under JKN, with only 18.75% of urologists reporting availability at their hospitals. CONCLUSION: Limited PSA testing following JKN implementation resulted in an increase in median PSA levels and a shift toward more advanced disease, suggesting an inability to detect prostate cancer at an early stage. These findings underscore the urgent need for targeted policy adjustments to enhance early detection, particularly in primary care settings.
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