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Oxidative Medicine And Cellular Longevity[JOURNAL]

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Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro.

Wagle S, Lee JA, Rupasinghe HPV

Oxid Med Cell Longev · 2024 · PMID 38268969 · Full text

Chaga mushroom () contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant pr... Chaga mushroom () contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties. This study investigated the cytotoxicity of different extracts prepared from and microalgae using cultured human and canine cancer cell lines (MCF-7, HepG2, HOS, D-17, and DH-82). MTS cell viability assay was used to study the cytotoxicity of and microalgae extracts, and a synergy matrix effect was used to study the combined effect of the extracts. Isobologram analysis and the highest single agent synergy model were applied to study and validate the synergy between the extracts from and microalgae. Ethanol-based extraction and supercritical water extract significantly inhibited the growth of various mammalian cancer cells compared to aqueous extracts. Osteosarcoma cells were more susceptible to the supercritical extracts of and chlorophyll-free and sugar-free ethanol extracts of microalgae. A combination of ethanol-based extract and chlorophyll-free microalgae extract resulted in a synergistic interaction with various tested cancer cells. This study provides experimental evidence supporting the potential therapeutic application of and microalgae extracts with a synergistic effect to inhibit the growth of various mammalian cancer cells. Additional in vivo studies are required to fully explore possible therapeutic applications of these unique mixtures to be used in treating cancers.
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Retracted: si-PDGFR-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway.

Longevity OMAC

Oxid Med Cell Longev · 2024 · PMID 38236530 · Full text

[This retracts the article DOI: 10.1155/2022/5081439.]. [This retracts the article DOI: 10.1155/2022/5081439.].
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Retracted: Antioxidant Indexes and Immune Function of the Intestinal Flora of Compound Microecological Preparations.

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Oxid Med Cell Longev · 2024 · PMID 38236495 · Full text

[This retracts the article DOI: 10.1155/2022/5498514.]. [This retracts the article DOI: 10.1155/2022/5498514.].
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Retracted: Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies.

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Oxid Med Cell Longev · 2024 · PMID 38234576 · Full text

[This retracts the article DOI: 10.1155/2022/9530007.]. [This retracts the article DOI: 10.1155/2022/9530007.].
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Retracted: Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats.

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Oxid Med Cell Longev · 2024 · PMID 38234575 · Full text

[This retracts the article DOI: 10.1155/2022/6482363.]. [This retracts the article DOI: 10.1155/2022/6482363.].
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Retracted: A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases.

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Oxid Med Cell Longev · 2024 · PMID 38234574 · Full text

[This retracts the article DOI: 10.1155/2022/4289383.]. [This retracts the article DOI: 10.1155/2022/4289383.].
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Retracted: The Protective Role of Brain CYP2J in Parkinson's Disease Models.

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Oxid Med Cell Longev · 2024 · PMID 38234573 · Full text

[This retracts the article DOI: 10.1155/2018/2917981.]. [This retracts the article DOI: 10.1155/2018/2917981.].
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Retracted: Composite Dietary Antioxidant Index and Plasma Levels of Soluble Klotho: Insights from NHANES.

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Oxid Med Cell Longev · 2024 · PMID 38234572 · Full text

[This retracts the article DOI: 10.1155/2023/3524611.]. [This retracts the article DOI: 10.1155/2023/3524611.].
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Retracted: Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation.

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Oxid Med Cell Longev · 2024 · PMID 38234571 · Full text

[This retracts the article DOI: 10.1155/2021/2094665.]. [This retracts the article DOI: 10.1155/2021/2094665.].
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Retracted: The Risk Model Based on the Three Oxidative Stress-Related Genes Evaluates the Prognosis of LAC Patients.

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Oxid Med Cell Longev · 2024 · PMID 38234570 · Full text

[This retracts the article DOI: 10.1155/2022/4022896.]. [This retracts the article DOI: 10.1155/2022/4022896.].
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Retracted: ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes.

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Oxid Med Cell Longev · 2024 · PMID 38234569 · Full text

[This retracts the article DOI: 10.1155/2021/5888432.]. [This retracts the article DOI: 10.1155/2021/5888432.].
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Retracted: Dietary Quercetin Supplementation Attenuates Diarrhea and Intestinal Damage by Regulating Gut Microbiota in Weanling Piglets.

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Oxid Med Cell Longev · 2024 · PMID 38234568 · Full text

[This retracts the article DOI: 10.1155/2021/6221012.]. [This retracts the article DOI: 10.1155/2021/6221012.].
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Retracted: Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury via Upregulating AMPK1 Expression.

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Oxid Med Cell Longev · 2024 · PMID 38234567 · Full text

[This retracts the article DOI: 10.1155/2022/3737137.]. [This retracts the article DOI: 10.1155/2022/3737137.].
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Retracted: Association between Oxidative Burden and Restenosis: A Case-Control Study.

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Oxid Med Cell Longev · 2024 · PMID 38234566 · Full text

[This retracts the article DOI: 10.1155/2022/3577761.]. [This retracts the article DOI: 10.1155/2022/3577761.].
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Retracted: Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects.

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Oxid Med Cell Longev · 2024 · PMID 38234565 · Full text

[This retracts the article DOI: 10.1155/2022/8615242.]. [This retracts the article DOI: 10.1155/2022/8615242.].
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Retracted: Assessing the Role of Nrf2/GPX4-Mediated Oxidative Stress in Arsenic-Induced Liver Damage and the Potential Application Value of Rosa roxburghii Tratt [Rosaceae].

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Oxid Med Cell Longev · 2024 · PMID 38234564 · Full text

[This retracts the article DOI: 10.1155/2022/9865606.]. [This retracts the article DOI: 10.1155/2022/9865606.].
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Retracted: Screening and Identification of Antidepressant Active Ingredients from Puerariae Radix Extract and Study on Its Mechanism.

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Oxid Med Cell Longev · 2024 · PMID 38234563 · Full text

[This retracts the article DOI: 10.1155/2021/2230195.]. [This retracts the article DOI: 10.1155/2021/2230195.].
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Retracted: Platelet-Rich Plasma-Derived Exosomal USP15 Promotes Cutaneous Wound Healing via Deubiquitinating EIF4A1.

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Oxid Med Cell Longev · 2024 · PMID 38234562 · Full text

[This retracts the article DOI: 10.1155/2021/9674809.]. [This retracts the article DOI: 10.1155/2021/9674809.].
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Retracted: MicroRNA-133b Inhibition Restores EGFR Expression and Accelerates Diabetes-Impaired Wound Healing.

Longevity OMAC

Oxid Med Cell Longev · 2024 · PMID 38234561 · Full text

[This retracts the article DOI: 10.1155/2021/9306760.]. [This retracts the article DOI: 10.1155/2021/9306760.].
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Retracted: Hemodynamic and Geometric Risk Factors for In-Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis.

Longevity OMAC

Oxid Med Cell Longev · 2024 · PMID 38234560 · Full text

[This retracts the article DOI: 10.1155/2022/6951302.]. [This retracts the article DOI: 10.1155/2022/6951302.].
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