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Journal Of Nuclear Cardiology[JOURNAL]

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Effect of deep learning attenuation correction on accuracy of stress myocardial perfusion imaging.

Lima BB, Dupont WD, Carr CM … +5 more , Jahangir E, Smith GT, Gregory SA, Plummer WD, Kronenberg MW

J Nucl Cardiol · 2026 May · PMID 42000122 · Publisher ↗

BACKGROUND: Attenuation correction (AC) improves the accuracy of myocardial perfusion imaging for detecting coronary artery disease (CAD). There has been limited application of deep learning attenuation correction (DLAC)... BACKGROUND: Attenuation correction (AC) improves the accuracy of myocardial perfusion imaging for detecting coronary artery disease (CAD). There has been limited application of deep learning attenuation correction (DLAC) in cadmium zinc telluride (CZT) cameras. METHODS: We employed DLAC for CZT imaging in a consecutive series of 100 patients with suspected CAD who had myocardial perfusion imaging with a DSPECT camera and coronary angiography. CAD was defined as left main stenosis ≥50% or another stenosis ≥70%. Automated analysis was compared with visual interpretation for the summed stress score (SSS) and was employed before (non-attenuation correction, NAC) and after DLAC. Accuracy was compared across upright, supine, and combined imaging positions using receiver operating characteristic analysis of the SSS, summed difference score (SDS), and a pixel-by-pixel approach. RESULTS: Automated analysis of SSS was not dissimilar to detailed visual analysis in the first 41 patients and was superior to visual analysis for the entire series. The SSS with NAC was highly accurate in detecting CAD (area under curve (AUC): 0.915) and was similar for SDS. DLAC was less accurate than NAC (P = 0.01 for SSS and 0.0003 for SDS). For SDS, upright imaging was superior to combined images (P = 0.002). The pixel-by-pixel analysis for reversibility correctly classified 93% of patients with NAC and 74% of patients with DLAC. CONCLUSIONS: For detecting CAD with a DSPECT camera, automated analysis for SSS had greater accuracy than visual analysis. While DLAC was effective, non-AC methods proved to be more accurate. Upright imaging was superior to combined imaging for detecting ischemia by SDS, highlighting opportunities to optimize CZT imaging protocols.
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Protocol optimization for F-flurpiridaz positron emission tomography myocardial perfusion imaging to enhance clinical workflow.

Ali FZ, Packard RRS

J Nucl Cardiol · 2026 Apr · PMID 41967882 · Publisher ↗

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Precision physiology in CAD.

Di Carli MF

J Nucl Cardiol · 2026 Apr · PMID 41967881 · Publisher ↗

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Targeting the "invisible" injury after myocardial infarction: Microvascular and sympathetic remodeling.

Weber BN, Aun JA

J Nucl Cardiol · 2026 Apr · PMID 41967880 · Publisher ↗

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Fluorine-18 flurpiridaz positron emission tomography myocardial perfusion imaging in women: A new radiotracer for improving coronary artery disease detection?

Veeranna V, Campisi R

J Nucl Cardiol · 2026 Apr · PMID 41967879 · Publisher ↗

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Moving toward positron emission tomography-determined phenotyping of coronary microvascular dysfunction?

Schindler TH, Ozkan E

J Nucl Cardiol · 2026 Apr · PMID 41967878 · Publisher ↗

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Top 3 practice-changing advancements in nuclear cardiology in 2025-2026.

Bourque JM

J Nucl Cardiol · 2026 May · PMID 41967825 · Publisher ↗

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Assessment of cardiac involvement in rare forms of amyloidosis using positron emission tomography/computed tomography with I-evuzamitide (I-p5+14, AT-01).

Clerc OF, Romero Pabón AJ, Cuddy SAM … +7 more , Bhimaniya S, Robertson M, Gracia SV, Di Carli MF, Bianchi G, Falk RH, Dorbala S

J Nucl Cardiol · 2026 Jun · PMID 41935606 · Publisher ↗

BACKGROUND: I-evuzamitide (I-p5+14, AT-01) is a novel pan-amyloid-binding radiotracer that accurately detects cardiomyopathy in light chain and wild-type transthyretin amyloidosis. However, data on this radiotracer are l... BACKGROUND: I-evuzamitide (I-p5+14, AT-01) is a novel pan-amyloid-binding radiotracer that accurately detects cardiomyopathy in light chain and wild-type transthyretin amyloidosis. However, data on this radiotracer are limited in rarer forms of amyloidosis, for which diagnosing cardiac involvement can be challenging. Hence, we investigated the ability of I-evuzamitide positron emission tomography/computed tomography (PET/CT) to detect cardiac involvement in rare forms of amyloidosis with or without known cardiomyopathy. METHODS AND RESULTS: We enrolled 10 participants with rare amyloidosis: 6 with cardiomyopathy (2 ATTRv p.T80A, ATTRv p.V142I, ATTRv p.L78H, AApoAIV, and AGel + ATTRwt) and 4 without cardiomyopathy (ATTRv p.G107R, 2 AApoAI, and localized pulmonary AL), and 12 control participants. They underwent PET/CT 5 hours after I-evuzamitide injection (median net injected activity: 0.97 mCi). Images were assessed visually, then myocardial radiotracer uptake above the blood pool was quantified using multiple metrics, including left ventricular percent injected dose (LV %ID = [LV mean activity concentration/injected activity] x LV activity volume x 100). All amyloidosis participants with cardiomyopathy exhibited visible myocardial uptake, while control participants showed no myocardial uptake. Among amyloidosis participants without cardiomyopathy, 3/4 exhibited myocardial uptake despite no signs of amyloidosis on echocardiogram, magnetic resonance imaging, and/or single-photon emission computed tomography. The participant with localized pulmonary AL showed normal myocardial uptake. LV %ID appropriately discriminated groups (P = 0.002): cardiomyopathy median: 1.74 (range: 0.20-2.53), no cardiomyopathy: 0.22 (0.00-1.16), control: 0.00 (0.00-0.02). CONCLUSIONS: I-evuzamitide PET/CT offers the potential to noninvasively diagnose cardiac involvement in rare forms of amyloidosis and may detect cardiomyopathy when other imaging methods are negative.
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Anatomical determinants of ischemia in myocardial bridging: A multimodality imaging study.

Liga R, De Gori C, Catalano F … +1 more , Gimelli A

J Nucl Cardiol · 2026 Apr · PMID 41935605 · Publisher ↗

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Gated single photon emission computed tomography imaging of left ventricular mechanical dyssynchrony: Predictive value in cardiac resynchronization therapy candidates.

Stępień-Wroniecka A, Szot W, Dziewięcka E … +10 more , Boczar K, Ząbek A, Holcman K, Graczyk K, Winiarczyk M, Przytuła N, Wiśniowska-Śmiałek S, Deleska K, Rubiś P, Kostkiewicz M

J Nucl Cardiol · 2026 Jun · PMID 41912136 · Publisher ↗

BACKGROUND: Cardiac resynchronization therapy (CRT) is recommended for patients with heart failure with reduced ejection fraction (HFrEF) who meet specific electrocardiographic (ECG) criteria of electrical dyssynchrony.... BACKGROUND: Cardiac resynchronization therapy (CRT) is recommended for patients with heart failure with reduced ejection fraction (HFrEF) who meet specific electrocardiographic (ECG) criteria of electrical dyssynchrony. Gated single-photon emission computed tomography (G-SPECT) is an imaging method that allows for the assessment of left ventricular mechanical dyssynchrony (LVMD); however, its predictive value for CRT response remains uncertain. This study aimed to evaluate the utility of G-SPECT in identifying LVMD and predicting CRT response in patients with HFrEF. METHODS: Patients with HFrEF and a LVEF <35% were prospectively enrolled and stratified into two groups: 60 patients CRT-eligible (Group 1) and 40 CRT-ineligible (Group 2). All patients underwent ECG, echocardiography, and G-SPECT imaging at baseline and at 6-month follow-up. LVMD was assessed using G-SPECT-derived parameters: (a) histogram bandwidth (HBW), (b) phase standard deviation (PSD), and (c) phase entropy, both at rest and under stress. CRT response was evaluated based on changes in LVEF. RESULTS: At baseline, patients in Group 1 exhibited greater LVMD as assessed by both echocardiography and G-SPECT. All G-SPECT-derived parameters, along with septal-to-posterior wall motion delay on echocardiography, were correlated with QRS duration. After CRT, LVMD significantly improved in Group 1. Super-response, defined as EF normalization, was observed in 11.9% of patients. G-SPECT-derived LVMD parameters, particularly rest PSD and entropy measures, were significant predictors of the favorable outcome of LVEF normalization. CONCLUSIONS: LVMD parameters obtained from G-SPECT were significantly correlated with electrical dyssynchrony as measured by QRS duration. Following CRT implantation, LVMD improved in parallel with increases in LVEF.
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Temporal changes in [13N]-Ammonia positron emission tomography myocardial perfusion imaging: Population characteristics and imaging findings over 25 years.

Sager DF, Caflisch C, Giannopoulos AA … +4 more , Pazhenkottil AP, Kaufmann PA, Buechel RR, Benz DC

J Nucl Cardiol · 2026 Mar · PMID 41905550 · Publisher ↗

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DOTA-based perfusion imaging in hybrid positron emission tomography/magnetic resonance: Promise, limits, and the importance of tracer kinetics.

Moura FA, Sinusas AJ

J Nucl Cardiol · 2026 May · PMID 41905549 · Publisher ↗

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Beyond fluorodeoxyglucose: High-definition macrophage imaging to predict heart failure.

Dobrucki LW

J Nucl Cardiol · 2026 May · PMID 41905548 · Publisher ↗

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Evaluating deep learning attenuation correction for single-photon emission computed tomography myocardial perfusion imaging: Lessons from clinical validation.

Shokravi A, Miller RJ

J Nucl Cardiol · 2026 May · PMID 41905547 · Publisher ↗

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When FDG misleads: Lateral wall uptake, dyssynchrony, and the risk of overdiagnosing cardiac sarcoidosis.

Pizzi MN, Roque A

J Nucl Cardiol · 2026 Mar · PMID 41866690 · Publisher ↗

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Refining signal from noise.

Di Carli MF

J Nucl Cardiol · 2026 Mar · PMID 41866689 · Publisher ↗

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Patient-centered care: Assessing coronary artery calcification and exercise ability in patients referred for nuclear cardiology stress testing.

Schwartz RG, Raco J

J Nucl Cardiol · 2026 Mar · PMID 41866688 · Publisher ↗

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Quantifying what matters: Clarifying the value of longitudinal flow gradients in [82Rb]rubidium-positron emission tomography myocardial perfusion imaging.

Murphy NP, Cremer PC

J Nucl Cardiol · 2026 Mar · PMID 41866687 · Publisher ↗

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Harnessing the full potential of positron emission tomography myocardial perfusion imaging with artificial intelligence.

Kwiecinski J

J Nucl Cardiol · 2026 Mar · PMID 41866686 · Publisher ↗

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Expanding American Society of Nuclear Cardiology's global partnerships-Collaboration benefits everyone.

Bourque JM

J Nucl Cardiol · 2026 Mar · PMID 41866685 · Publisher ↗

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