Acta Informatica Medica[JOURNAL]
Sun
200 papers
Impact of Surgical Timing on Mortality and Functional Outcomes in Elderly Hip Fracture Patients: a Retrospective Cohort Study.
Essa SB, Anaqreh Y, Abueed M … +7 more , Alrawashdeh M, Hussein N, Al-Sa'adi Y, Batbouta J, Alkhatatba M, Mohaidat ZM, Radaideh A
Acta Inform Med · 2024 · PMID 40061008 · Full text
BACKGROUND: Hip fractures among the elderly stem from low-energy trauma and frequently coincide with osteoporosis or low bone mass, along with other related medical conditions that heighten, the risk of falls with the ma...
BACKGROUND: Hip fractures among the elderly stem from low-energy trauma and frequently coincide with osteoporosis or low bone mass, along with other related medical conditions that heighten, the risk of falls with the majority of hip fractures manifest in women aged over 65 years, with an estimated global annual incidence of approximately 1.7 million. The incidence is expected to rise in tandem with increasing life expectancy and the expanding population of elderly individuals and those grappling with chronic health conditions. OBJECTIVE: The aim of this study was to assess the impact of surgical timing on mortality and functional outcomes in elderly hip fracture patients and identify systemic factors contributing to delays. METHODS: This retrospective cohort study analyzed 236 patients aged ≥50 years with surgically treated hip fractures at King Abdullah University Hospital, Jordan (2019-2022). Patients were stratified into early (≤3 days post-admission) and delayed (>3 days) surgery groups. Data on demographics, comorbidities, surgical variables, and outcomes were extracted from electronic health records. Statistical analyses included Wilcoxon rank sum, Chi-squared tests, and logistic regression to evaluate associations between surgical delay and mortality. RESULTS: Delayed patients (31.8%) exhibited significantly higher 1-year mortality (31% vs. 12%, p<0.001), longer hospital stays (11.2 vs. 5.9 days, p<0.001), and reduced ambulation at 3 months (36% vs. 16% non-ambulatory, p<0.001). Logistic regression identified surgical delay as an independent mortality predictor: delayed patients with ≥3 comorbidities had 9.02-fold higher odds of death (95% CI: 1.67-167.85, p=0.038), while those with <2 comorbidities had a 13.18-fold increase (95% CI: 2.27-251.18, p=0.017). Systemic barriers included preoperative ICU admissions (12% vs. 1.2%, p<0.001) and lower preoperative hemoglobin levels (11.26 vs. 11.87 g/dL, p=0.012). CONCLUSION: Surgical delay beyond three days independently elevates mortality and disability risks in hip fracture patients, irrespective of comorbidities. Timely intervention mitigates comorbidity-related risks, underscoring the need for multidisciplinary pathways and policy reforms to reduce delays.
Assessing the Efficacy of Extended Postoperative Enoxaparin as Thromboprophylaxis for Patients Undergoing Laparoscopic Sleeve Gastrectomy: a Prospective Analysis.
Mazahreh T, Al-Jarrah M, Al-Salhi A … +5 more , Al-Jarrah H, Bayyari S, Alahmad B, Aleshawi A, Iannelli A
Acta Inform Med · 2024 · PMID 40061007 · Full text
BACKGROUND: Venous thromboembolism (VTE), encompassing deep venous thrombosis (DVT) and pulmonary embolism (PE), presents significant morbidity and mortality risks post-bariatric surgery. Despite the recognized need for...
BACKGROUND: Venous thromboembolism (VTE), encompassing deep venous thrombosis (DVT) and pulmonary embolism (PE), presents significant morbidity and mortality risks post-bariatric surgery. Despite the recognized need for thromboprophylaxis, optimal strategies, particularly regarding the duration and dosing of chemoprophylaxis, remain under debate. OBJECTIVE: This study evaluates the efficacy of standard versus extended chemoprophylaxis with enoxaparin in preventing VTE following laparoscopic sleeve gastrectomy (LSG) at King Abdullah University Hospital in Irbid, Jordan. METHODS: A prospective cohort study included patients undergoing LSG from January to July 2023. Excluding high-risk individuals based on specific criteria, participants were randomized into two groups: standard prophylaxis (Group A) and extended prophylaxis with enoxaparin for 14 days post-discharge (Group B). Both groups were assessed preoperatively and followed up to one month postoperatively for signs of DVT via venous Doppler ultrasound and for any complications related to enoxaparin use. RESULTS: Of the 116 patients studied, no DVT incidents were reported across both groups. Preoperative and postoperative assessments showed significant weight loss, with no complications associated with enoxaparin. Statistical analysis indicated no significant difference in DVT prevention between groups. The study's findings align with existing literature, underscoring the safety of enoxaparin but questioning its impact on DVT incidence post-LSG. CONCLUSION: The study concludes that extended chemoprophylaxis with enoxaparin post-LSG is safe, with no reported adverse effects. However, its efficacy in significantly reducing postoperative DVT incidence remains uncertain. These outcomes suggest the need for further research with larger sample sizes to optimize thromboprophylaxis strategies, considering patient-specific factors and potential risks.
Bibliometric Indexes - Advantages and Limitations in Practical Application, for the Scientific Validity of Authors and Their Scientific Contents - Stanford Bibliometric List: Truths and Misconceptions.
Masic I
Acta Inform Med · 2024 · PMID 40061006 · Full text
BACKGROUND: The scientific researchers have the role of interacting through published articles in scientific journals or presentations at scientific and professional conferences where they can affect the practices that c...
BACKGROUND: The scientific researchers have the role of interacting through published articles in scientific journals or presentations at scientific and professional conferences where they can affect the practices that can make achievements to society and country. or worldwide. OBJECTIVE: The aim of this article was to describe bibliometric indexes and explained its importance for its evaluation and measuring quality assessment of published papers in scientific journals and advantages and disadvantages of current bibliometric portals for creating the list of universities and its academic staff by counts of deposited articles in databases and number of its citations. METHODS: The author searched the most influential online databases and analyzed deposited papers by bibliometric indexes, and used a descriptive method to review important facts about bibliometrics experiences in scientific and academic practice. The author used facts deposited on the main international portals for analyzing number of citations of deposited scientific papers on Scopus and Google Scholar platform-h-Index and i10-Index and number of citations as basic data for created top list of most citated scientists in almost of all countries in the world. RESULTS AND DISCUSSION: Bibliometric methods are used for quantitative analysis of written materials. Citation is influenced by: article quality, understanding of the article, language in which the article is written, loyalty to a group of researchers, article type, etc. Some indicators used in evaluating scientific work are Impact factor (IF); Citation of the article; Journal citations; Number and order of authors, etc. The index factor of influence depends on the quality of the journal, the language in which it was printed, the area it covers, and the journal distribution system. The portals and its platforms: Webometrics, "AD Scientific Index" and Stanford Bibliometric List are not fully relevant for measuring quality assessment of universities and its academic staff. CONCLUSION: Current academies and academicians can propose criteria how improve indexing scientific papers with the consultation of scientific bodies and experts at universities in one country, selected regions, or worldwide. These criteria should be necessary for quality assessment of the scientific curriculum of scientists and their published papers in scientific journals.
Type of Personality and Characteristics of Nurses in Pediatric Intensive Care Unit.
Georgia K, Maria P, Afroditi Z … +4 more , Eleni E, Chrysoula D, Evangelos D, Ioannis K
Acta Inform Med · 2024 · PMID 40061005 · Full text
BACKGROUND: In recent years, correlation between personality and professional success has become increasingly evident. In modern times, it is well accepted that a persons' personality combined with their abilities are a...
BACKGROUND: In recent years, correlation between personality and professional success has become increasingly evident. In modern times, it is well accepted that a persons' personality combined with their abilities are a prerequisite for the successful practice of any profession. OBJECTIVE: The aim of this study was to explore factors associated with ICU nurses' personality types. METHODS: The sample of the study included 102 nurses working pediatric ICUs. Data collection was performed by the method of the interview using the questionnaire "Greek Version of the TIPI (Ten-Item Personality Inventory)"which includes the following traits: a) Openness to Experience, b) Conscientiousness, c) Extraversion, d) Agreeableness and e) Emotional Stability. RESULTS: A fairly high "agreement" (above average) was observed with all five personality types of the "TIPI" scale (median val ≥5 in all subscales). After multiple linear regression, it was found that nurses who wished to move from the ICU have 0.42 units lower "Extraversion" compared to those who do not wish to (β=-0.42, 95%CI: -0.88 - -0.04). An increase in the age of the nurses by one year increases the score of "Agreeableness" by 0.02 units (β=0.02, 95%CI: 0.01 - 0.04) and the score of "Conscientiousness" by 0.03 points (β=0.03, 95%CI: 0.01 - 0.06). Male pediatric ICU nurses have a 3.95-point higher score of "Openness to experience" than women (β=3.95, 95%CI: 2.96-5.64). No factor was found to be significantly associated with "emotional stability". CONCLUSION: Conclusion: Nurses characteristics are associated personality traits. For the health sciences, this is important to recognizes the vital characteristics that make a health professional a competent, safe and ethical worker.
The First Original Medical Professional Printed Book in Southeast Europe.
Fures R, Hrgovic Z, Cosic V … +4 more , Gredicak M, Malojcic SM, Krajcar M, Kranjcec B
Acta Inform Med · 2024 · PMID 40061004 · Full text
BACKGROUND: The author of the first Croatian medical book, also the first in Southeast Europe, was Dr.John the Baptist Lalangue. He is the one who is most responsible for the fact that in the second half of the 18th cent...
BACKGROUND: The author of the first Croatian medical book, also the first in Southeast Europe, was Dr.John the Baptist Lalangue. He is the one who is most responsible for the fact that in the second half of the 18th century. OBJECTIVE: The aim of thiis article was to describe important facts abot the first original medical professional printed books in the Croatian language. METHODS: The authors searched imprtant information abot the book of the author Lalangue's titled "Medicina ruralis iliti Vrachtva ladanyszka, za potrebochu musev, y sziromakov. Horvatczkoga orszaga y okolu nyega, blisnesseh meszt" deposited in libraries in Zagreb and Varazdin, and also published articles deposited in scientific databases PubMed, PubMed Central, EBSCO., etc. RESULTS AND DISCUSSION: The original medical first printed in the area of Southeast Europe by John the Baptist Lalangue is a book that deserves admiration. It is also the first printed original medical book in the Croatian language. The book "Medicina ruralis iliti Vrachtva ladanyszka, za potrebochu musev, y sziromakov. Horvatczkoga orszaga y okolu nyega, blisnesseh meszt" was published by Lalangue in Varaždin in 1776 at the Trattner printing house. After that, doctor Lalangue published a series of capital works of Croatian medicine, as well as medicine of Southeast Europe. CONCLUSION: Doctor Lalangue is the author of a Croatian midwifery textbook and a balneological first, which are also firsts in the area of Southeast Europe. In this way, we remember the greats of medical thought and express the desire to respect him in accordance with his magnificent achievements.
Development of MitoWizz: a Bioinformatics Solution for Mitochondrial DNA Analysis in Both Forensic and Clinical Applications.
Handzic N, Pecar D, Durgut S … +2 more , Salihefendic L, Konjhodzic R
Acta Inform Med · 2024 · PMID 40061003 · Full text
BACKGROUND: MitoWizz is an advanced bioinformatics tool designed for the analysis of the human mitochondrial genome, offering precise and efficient data interpretation. It enables comparisons of sequencing results obtain...
BACKGROUND: MitoWizz is an advanced bioinformatics tool designed for the analysis of the human mitochondrial genome, offering precise and efficient data interpretation. It enables comparisons of sequencing results obtained from various instrumental methods with the reference Andersen genome (rCRS), aiding in the identification of alterations. This capability is particularly valuable in forensic and clinical mitochondrial DNA analysis. OBJECTIVE: The primary goal of developing MitoWizz is to automate and streamline mitochondrial DNA analysis, providing researchers and forensic experts with a fast, reliable, and comprehensive tool for sequence comparison, variation detection, and data validation. METHODS: MitoWizz compares query sequences in opposed to the reference genome and allows direct comparison of two sequences to identify genetic variations. To ensure accuracy, the results are validated through the Clustal Omega W by aligning sequences with the human mitochondrial DNA reference from GenBank (NC_012920.1). RESULTS: The software detected genetic variations and generated a visual report, as demonstrated in an analysis where 11 mutations were identified in various genes, with an 88% sequence identity to the reference genome. The accuracy of the detected alterations was further validated using the Omega Clustal W program. CONSLUSION: MitoWizz significantly reduces analysis time and enhances result reliability by integrating multiple analytical steps into a single platform. By automating mtDNA comparisons and validation, it provides forensic and research laboratories with a high-throughput, efficient solution for precise mitochondrial genome analysis.
Clinical Features of Children With Anti-N-Methyl-D-Aspartate Receptor Encephalitis Following Viral Encephalitis.
Phuong VTM, Thuy PTB, Nam DH … +2 more , Van NTB, An PN
Acta Inform Med · 2024 · PMID 40061002 · Full text
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) can occur after herpes simplex encephalitis (HSE) and Japanese encephalitis (JE). We describe the clinical features of children with anti-NMDARE a...
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) can occur after herpes simplex encephalitis (HSE) and Japanese encephalitis (JE). We describe the clinical features of children with anti-NMDARE after viral encephalitis. OBJECTIVE: This study aims to describe the clinical characteristics, laboratory findings, and treatment outcomes of these patients. METHODS: We describe the clinical characteristics of 14 children of anti-NMDARE following viral encephalitis treated at National Children's Hospital from January 2021 to December 2022. Patients with evidence of viral reactivation or other antibodies were excluded. RESULTS: There are 12 children with anti-NMDARE after HSE and 2 children after JE. The median age was 2.1 years (range 0.6-12.9), with 8 male patients. All patients (100%) had fever and seizures, while 50% exhibited focal neurological signs. No patients experienced movement disorders, psychiatric symptoms, or sleep disturbances during the viral encephalitis phase. In contrast, the most common symptoms during the anti-NMDARE phase were as follows: movement disorders in 92.9% (13/14), recurrent or prolonged fever in 71.4% (10/14), sleep disturbances in 64.3% (9/14), seizures in 50% (7/14), and psychiatric symptoms in 50% (7/14). The median cerebrospinal fluid (CSF) white blood cell count in the viral encephalitis and anti-NMDARE phases was 57 (4-410) and 13 (2-48), respectively. The mean CSF protein concentration was 0.43 ± 0.16 g/L and 0.85 ± 0.63 g/L, respectively. Brain MRI was performed in both encephalitis phases for 10/14 patients, with 8/10 showing no new lesions. CONCLUSION: There were differences in clinical symptoms and CSF findings between the two phases of encephalitis; however, most patients did not develop new lesions on brain MRI.
Population Effect of Croslinking Treatment for Keratoconus in a Pediatric Population.
Pandurevic B, Ahmedbegovic-Pjano M, Grisevic S … +4 more , Bejdic N, Skopljak-Salkica A, Mravicic I, Biscevic A
Acta Inform Med · 2024 · PMID 40061001 · Full text
BACKGROUND: Keratoconus is a progressive condition that weakens the cornea and affects vision. Symptoms typically emerge in the second or third decade of life, though rare cases in young children occur. Early diagnosis i...
BACKGROUND: Keratoconus is a progressive condition that weakens the cornea and affects vision. Symptoms typically emerge in the second or third decade of life, though rare cases in young children occur. Early diagnosis is crucial to prevent vision deterioration. OBJECTIVE: The aim of this study was to evaluate the effectiveness of the accelerated crosslinking treatment for keratoconus in the pediatric population. METHODS: This prospective study evaluated 20 eyes in 13 patients with keratoconus who underwent accelerated crosslinking procedures at Eye Clinic Svjetlost Sarajevo with a one-year follow-up. Participants aged 12 to 18 had a confirmed keratoconus diagnosis and corneal thickness over 400 microns. Preoperative examinations included visual acuity (LogMAR scale), keratometry measurements, central corneal thickness, and keratoconus grading using the ABCD system on a Pentacam. RESULTS: Postoperative results showed stability and postoperative improvement of uncorrected and corrected visual acuity (P < 0.001). Postoperative keratometries, specifically Km and Kmax, showed a statistically significant decrease, flattening by approximately 1 diopter (D) and 1.5 diopters (D), respectively. Results of postoperative ABCD score showed stability, without postoperative deviation from the mean value and standard deviation. Central corneal thickness values decreased to 456.48 ± 27.2 μm at the one-year examination, and were statisticaly significant compared to preoperative values (P < 0.001). CONSLUSION: Stopping progression with crosslinking is the single most important part of management of the pediatric keratoconus patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the only treatment for pediatric keratoconus that has been proven to halt the progression of the disease and prevent prolonged reduction in a child's visual acuity.
Skopje Declaration on Scientific and Publishing Integrity in Biomedicine.
Karanfilska DP, Mircheski V, Donev D … +4 more , Ristovska G, Elezi N, Trajkovski V, Gligorov I
Acta Inform Med · 2024 · PMID 39959685 · Full text
Abstract loading — click title to view on PubMed.
Left Portal Hypertension and Hypersplenism in a Child With Congenital Diaphragmatic Hernia: A Rare Case Report.
Tri TT, Thuan LA, Kiet PT … +2 more , Huy AN, Vi TH
Acta Inform Med · 2024 · PMID 39959684 · Full text
BACKGROUND: T Congenital diaphragmatic hernia (Bochdalek hernia), which occurs in 1/2,200 live births, is typically diagnosed in the prenatal or immediate postnatal period. Diaphragmatic hernia is rare in older children...
BACKGROUND: T Congenital diaphragmatic hernia (Bochdalek hernia), which occurs in 1/2,200 live births, is typically diagnosed in the prenatal or immediate postnatal period. Diaphragmatic hernia is rare in older children and adults and can be presented with acute respiratory failure, incarcerated hernia, acute pancreatitis, or rare conditions such as left portal hypertension and hypersplenism. OBJECTIVE: The aim of this case report was to present 15-year-old male with vomiting and mild upper abdominal pain who had mild epigastric tenderness with no guard and an IV grade splenomegaly caused by Congenital Diaphragmatic Hernia. Case presentation: We report a case of left portal hypertension and hypersplenism in an adolescent with congenital diaphragmatic hernia. Typical clinical presentations include abdominal pain, respiratory symptoms, or intestinal obstruction in incarcerated diaphragmatic hernia. Additionally, some uncommon symptoms reported in literature include gastrointestinal bleeding as a result of portal hypertension, thrombocytopenia due to hypersplenism, and acute pancreatitis. CONCLUSION: The treatment has released the obstruction in the splenic vein and reduce returned collateral gastric blood flow. Splenectomy should be considered based on many factors, such as anatomic anomalies or the degree of hypersplenism and portal hypertension. This is a rare clinical entity with only a few cases that have been reported in the literature.
On the Occasion of Marking 30 Years of Editorial Work with the Journals "Medical Archives" and "Acta Informatica Medica".
Zildzic M
Acta Inform Med · 2024 · PMID 39959683 · Full text
Abstract loading — click title to view on PubMed.
Novel Intronic Heterozygous Mutation in TSC2 Gene in Pediatric Patient with Tuberous Sclerosis Complex.
Konjhodzic R, Salihefendic L, Mulahuseinovic N … +5 more , Ceko I, Durgut S, Handzic N, Orucevic S, Uzicanin S
Acta Inform Med · 2024 · PMID 39959682 · Full text
BACKGROUND: Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder and involves multiple organs, intellectual disability and epilepsy. Mutations in TSC1 and TSC2 genes are responsible for the molecula...
BACKGROUND: Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder and involves multiple organs, intellectual disability and epilepsy. Mutations in TSC1 and TSC2 genes are responsible for the molecular disease mechanism. OBJECTIVE: The aim is to determine molecular background of a patient with a suspicion of TSC. CASE PRESENTATION: In this case report, we describe a seven year old patient with the clinical manifestation of TSC that includes supratentorial changes, subependymal hamartomas and angifibromas in the facial area. Besides the brain and skin changes, no other TSC characteristics were observed. The patient was referred to molecular genetic testing using Next Generation Sequencing (NGS). Results: Clinical exome sequencing revealed intronic TSC2 c.4849+2T>G variant. The variant was confirmed using Sanger sequencing on the subject. However, the variant was not detected in the parents, which indicated that it arose de-novo. The RegSNP-intron, Mutation Taster and Human Splicing Finder were used as a bioinformatic tools to predict the possible effect on protein. Using bioinformatic tools, it was determined that the variant is possibly damaging to protein. CONCLUSION: This data suggest that observed splicing intronic variant could be the cause of TSC in this pediatric patient.
Evaluation of Human Carbonic Anhydrase II (CA-II) Concentration Using ELISA: Insights into Optical Density's Role in Biomarker Quantification for Cryptorchidism Research.
Nurhadi P, Daryanto B, Purnomo AF … +2 more , Kusworini, Alfandy TN
Acta Inform Med · 2024 · PMID 39959681 · Full text
BACKGROUND: Carbonic Anhydrase II (CA-II) plays a pivotal role in various physiological processes, including maintaining acid-base balance. Its implications in testicular health, especially cryptorchidism, make it an ess...
BACKGROUND: Carbonic Anhydrase II (CA-II) plays a pivotal role in various physiological processes, including maintaining acid-base balance. Its implications in testicular health, especially cryptorchidism, make it an essential focus for researchers. ELISA is widely used to measure biomarker concentrations, with OD serving as a key indicator. Understanding the precision of OD measurements for CA-II can enhance its diagnostic and research applications. OBJECTIVE: This study aims to evaluate the relationship between OD and CA-II concentration using linear regression analysis, thereby establishing a quantitative framework for accurate and reproducible CA-II measurements. By validating the OD-to-concentration relationship, this research will aid in developing standardized protocols that can improve diagnostic reliability, enhance monitoring of disease progression, and support therapeutic interventions targeting CA-II. METHODS: Standardized ELISA was employed to determine CA-II concentrations across sample groups, recording OD at specific wavelengths. Data were analyzed for linearity, group differences using ANOVA, and pairwise comparisons via Tukey's HSD test. Correlation analysis was performed to evaluate the relationship between CA-II concentration and OD. RESULTS: A linear regression model (y=0.3758x+0.1604) demonstrated a nearly perfect R2 value of 0.9957. Statistical tests revealed a strong correlation (0.998) between CA-II concentration and OD values. ANOVA did not indicate significant differences among concentration quartiles; however, the data strongly supported OD's use as a reliable proxy for CA-II measurement. CONCLUSION: The established linear relationship between CA-II concentration and OD confirms the accuracy of ELISA in CA-II measurement. This methodology supports future investigations into CA-II's involvement in testicular health, potentially aiding in diagnostics and understanding of conditions such as cryptorchidism.
Assessement of Radiological Anatomy of Prostatic Artery on 3D DECT in Symptomatic Benign Prostatic Hypertrophy.
Binh NT, Thien LQ, Huyen DK … +4 more , Duy NQ, Anh NTH, Dung LT, Hung ND
Acta Inform Med · 2024 · PMID 39959680 · Full text
BACKGROUND: Benign prostatic hyperplasia (BHP) is a common disease in the urinary system and often appears in old male patients with the incidence increasing proportionally to age. OBJECTIVE: The study aimed to describe...
BACKGROUND: Benign prostatic hyperplasia (BHP) is a common disease in the urinary system and often appears in old male patients with the incidence increasing proportionally to age. OBJECTIVE: The study aimed to describe the anatomy and imaging findings of the prostatic artery (PAs) on 3D rendering dual-energy multi-sequence computed tomography (DECT) in patients with symptomatic benign prostatic hypertrophy (BPH) treated by prostatic artery embolisation (PAE). METHODS: The study was conducted on 64 patients with BPH who underwent DECT scans with 3D rendering of the pelvic artery before intervention from August 2022 to November 2023. The PAs were independently evaluated for each side, focusing on the number of branches, origin, tortuosity, atherosclerotic plaque, and anastomoses with adjacent arteries. RESULTS: Among 128 pelvic sides where the PAs can be observed, the rate of finding 01 prostate artery on each side was high (96.1%), and the rate of 02 prostate arteries on each side was rare (3.9%). In 133 prostatic arteries, the most common type of prostatic artery according to origin is type I (29.6%), followed by type III (24.6%). The atherosclerotic prostatic artery rate is 24.6%, and the average diameter is 1.5±0.4 mm. The tortuosity prostate artery accounted for 74.6%. The anastomosis to the contralateral prostatic artery rate is 48.4%, followed by the penis and rectum anastomoses. CONCLUSION: PAs have abundant original varies between the left and right sides and between patient to patient. The most common form arises from the internal pudendal artery.
Fifteen Years Anniversary of MIE 2009 Conference Held in Sarajevo in the Period August 30th-September 2nd 2009 - Review.
Masic I
Acta Inform Med · 2024 · PMID 39959679 · Full text
Abstract loading — click title to view on PubMed.
Spigelian Hernia in Cirrhotic Patients: When and How to Repair?
Telmesani N, Boumarah D, Alkhaldi N … +4 more , Alsadery H, Busbait S, AlOthman A, Alaqeel F
Acta Inform Med · 2024 · PMID 39959678 · Full text
BACKGROUND: Spigelian hernia, also known as spontaneous lateral ventral hernia, is defined as a protrusion of abdominal contents through an abdominal wall defect within the transversus aponeurosis. The entity was first r...
BACKGROUND: Spigelian hernia, also known as spontaneous lateral ventral hernia, is defined as a protrusion of abdominal contents through an abdominal wall defect within the transversus aponeurosis. The entity was first reported in 1742 and named after Adrian van der Spieghel. It is recognized as a rare condition, accounting for 1 to 2% of all abdominal wall hernias. Cirrhotic patients, in particular, are more predisposed to hernias of all types. When Spigelian hernia is accompanied by hepatic cirrhosis, the decision to repair gets into a controversial aspect. Herein, we present the emergency management of an incarcerated spigelian hernia in a cirrhotic patient, highlighting the challenges in managing similar cases. CASE PRESENTATION: A 65-year-old lady, presented to our emergency department complaining of a left lower quadrant (LLQ) abdominal pain associated with a painful swelling for 9 hours duration. Upon assessment, the patient was jaundiced and haemodynamically stable. Abdominal examination revealed a soft and lax but distended abdomen, with irreducible tender swelling over the LLQ, measuring around 3x2 cm. Laboratory investigations showed anemia, hypoalbuminemia, hyperbilirubinemia, lactic acidosis and prolonged coagulation profile. A contrast-enhanced computed tomography (CT) scan of the abdomen showed evidence of incarcerated left spigelian hernia. Moreover, advanced cirrhosis of the liver was detected with hypertrophy of the caudate lobe, extensive ascites and splenomegaly. After establishing the diagnosis of incarcerated spigelian hernia, with a picture of advanced liver cirrhosis, Child-Pugh-Turcotte (CPT) score of C and a Model for End-Stage Liver Disease (MELD) score of 19 and Mayo score for post-operative mortality of 16% in 7 days and 53% in 30 days. Given the patient's condition which necessitates urgent operative intervention beside the risk of decompensation of pre-existing liver disease and high mortality. Decision was made to proceed with laparoscopic hernia repair. Intraoperatively, ischemic small bowel segment was resected with creation of end ileostomy. Conventional anatomical repair of the hernia defect was performed. Postoperatively, the patient was managed and resuscitated in critical care unit and then discharged home in a satisfactory condition on post-operative day 15. She passed away prior to liver transplantation, thirty-two days post-operatively in a different institution. CONCLUSION: The surgical management of complicated hernias in an emergency setting comprise a notable number of cases encountered by surgeons. It always needs special attention. Moreover, cirrhotic patients with their predicted high morbidity and mortality require even further vigilance. Therefore, a patient-tailored approach is always recommended when managing similar cases to provide optimal outcomes.
Cardiac Arrest Caused by Amniotic Fluid Embolism: a Report of Two Clinical Cases.
Bui DT, Bui DHT, Tran TTT … +4 more , Vu VH, Tran TN, Huynh KA, Nguyen DH
Acta Inform Med · 2024 · PMID 39959677 · Full text
BACKGROUND: Amniotic fluid embolism (AFE) is a rare and catastrophic obstetric complication that can lead to sudden cardiac arrest, respiratory distress, and disseminated intravascular coagulation. Recognizing and managi...
BACKGROUND: Amniotic fluid embolism (AFE) is a rare and catastrophic obstetric complication that can lead to sudden cardiac arrest, respiratory distress, and disseminated intravascular coagulation. Recognizing and managing this condition promptly is crucial for improving maternal and neonatal outcomes. OBJECTIVE: This report includes two case studies describing the timely detection, prompt delivery of medical treatment, and the interdisciplinary approach essential for achieving better outcomes for mothers and children confronting with this catastrophic condition. CASE PRESENTATION: Case 1: A 39-year-old pregnant woman at 36 weeks and 5 days of gestation with central placenta previa was admitted due to antepartum hemorrhage. She developed convulsions and cardiac arrest during a cesarean section, requiring cardiopulmonary resuscitation. Laboratory tests revealed severe anemia, thrombocytopenia, coagulopathy, severe acidosis, and myocardial injury. Bedside echocardiography and CT scan identified high-risk pulmonary embolisms. Intensive care included VA-ECMO, CRRT, transcatheter arterial embolization, and mechanical thrombectomy. Histopathology confirmed amniotic fluid components making up the emboli. Case 2: A 31-year-old female was transferred following a cesarean section for central placenta previa complicated by severe hemorrhage, cardiac arrest, and pulmonary embolism. Laboratory results showed severe anemia, thrombocytopenia, significant coagulopathy, myocardial injury, and hepatic injury. Histopathology confirmed amniotic components in the embolism. Management involved extensive blood transfusions, and pulmonary thromboendarterectomy. She was discharged in improved condition. CONCLUSION: Early diagnosis and prompt intervention are crucial to optimizing outcomes for patients with amniotic fluid embolism, utilizing a comprehensive multidisciplinary approach.
The Role of Neural Network Analysis in Identifying Predictors of Gastric Cancer.
Siyam AA
Acta Inform Med · 2024 · PMID 39959676 · Full text
BACKGROUND: Gastric cancer is one of the most common cancers. We can use AI for predictive models and help us in early detection and diagnosis. OBJECTIVE: This study examines the use of a neural network model to classify...
BACKGROUND: Gastric cancer is one of the most common cancers. We can use AI for predictive models and help us in early detection and diagnosis. OBJECTIVE: This study examines the use of a neural network model to classify gastric cancer based on clinical, demographic and genetic data. METHODS: The data from the participants were divided into two subsets. 70% training data and 30% testing data. The neural network model has 12 input variables. Factors influencing a disease can be age, sex, family history, smoking, alcohol, Helicobacter pylori infection, food habits, diseases, endoscopic images, biopsy, CT scan, gene variants (TP53, KRAS, CDH1). The hyperbolic tangent activation function has four units in the hidden layer of a model. The output layer used a Softmax activation function and cross-entropy error function which predicted the presence of gastric cancer. The assessment was done on the predictors. RESULTS: The training and testing datasets showed 100% accuracy predicting gastric cancer in the model outputs. Age, gender, family history, infection with Helicobacter pylori, smoking, and drinking alcohol are the biggest predictors. Information from clinical diagnosis like endoscopic images, biopsy and CT scans helped the predictive model. CONCLUSION: The neural network was able to perform well for gastric cancer predictions using multiple clinical and demographic factors, showing great utility. The outcomes for AI-based diagnostic tools look promising in cancer, however generalization needs to be confirmed using external datasets. The study shows how artificial intelligence can better precision medicine and cancer diagnosis.
Direct Reciprocal Interaction Between Platelet Count and HBeAg Status in HBsAg-positive Pregnant Women.
Dung NT, Huong BTT, Tu HC … +1 more , Tram HTN
Acta Inform Med · 2024 · PMID 39959675 · Full text
BACKGROUND: Chronic hepatitis B virus (HBV) infection is a global health issue with a significant impact on pregnant women, mainly due to the interplay between liver function and hematological changes. The liver plays a...
BACKGROUND: Chronic hepatitis B virus (HBV) infection is a global health issue with a significant impact on pregnant women, mainly due to the interplay between liver function and hematological changes. The liver plays a key role in erythropoiesis and systemic hemostasis. In HBeAg-positive pregnant women, platelet dynamics may be uniquely influenced by the interaction of HBV, immune modulation in pregnancy, and liver function. This area remains underexplored. OBJECTIVE: Our study aimed to analyze the interaction between HbeAg status with others preclinical factors by using the matrix correlation and multidimensional statistics methods. METHODS: We used SEM (Structural Equation Modeling) to demonstrate and quantify the direct reciprocal interaction between platelet count and HBeAg status in HBsAg-positive pregnant women. RESULTS: We found the quantity of platelet, with the optimal threshold is 201x10^3cells/ml, directly relates with HBeAg status (R =0.24) and negatively correlates with ratio of AST on ALT (R=-0.139). In case of HbeAg positive, the risk ratio having a high quantity of platelet (>201x103cells/ml) and high AST/ALT ratio (>1.42) is 2.16[1.23,3.80] (p<0.05). SEM model shows that platelet count has a direct impact on HBeAg (p<0.05, Coefficient =0.24) and indirectly through the AST/ALT ratio. This impact is greater than the direct impact from HBeAg on platelet count (p < 0.05, coefficient = 0.23). CONCLUSION: Research results show a complex relationship between platelet count, AST/ALT ratio and HBeAg in patients with chronic hepatitis B. The direct interaction between platelet count, HBeAg status, and AST/ALT ratio suggests intriguing complex immuno-biochemical responses to chronic hepatitis B virus (HBV) infection.
The Value of Non-invasive Electrocardiography in Assessing Fetal Status at Term Delivery.
Theodoridou A, Koukou Z, Taousani E … +2 more , Antonakou A, Gourounti K
Acta Inform Med · 2023 · PMID 37781499 · Full text
BACKGROUND: The electrocardiograph (ECG) is efficient method for the accurate assessment of fetal heart rate. The barriers for accurate assessment are maternal heart rate, uterine contractions and abdominal muscles. Alth...
BACKGROUND: The electrocardiograph (ECG) is efficient method for the accurate assessment of fetal heart rate. The barriers for accurate assessment are maternal heart rate, uterine contractions and abdominal muscles. Although previous monitoring methods have struggled to overcome these barriers, recent advances have led to a greater degree of success for listening and recording pulse-by-pulse fetal heart rate. OBJECTIVES: A prospective cohort study evaluating the use, reliability and safety of non-invasive electrocardiography, in conjunction with Fetal Heart Rate parameters such as, Short Term Variability (STV) together with umbilical cord PH and Apgar score, during the active phase of childbirth. METHODS: A total of 41 women with single, normal, full-term pregnancies had systematic obstetric monitoring with Monica AN24. 20 had only monitoring and 21 also had and arterial blood flow measurements. pH was measured and correlated with neonatal Apgar score at 1 and 5 min. The study also included a questionnaire about the safety and usability of obstetric monitoring. Statistical analysis was done using IBM SPSS v. 26.0. RESULTS: Mean age was 28.8 years, (SD ± 6.153). Electrocardiogram recordings (ECG) were classified as normal (71%) and suspicious (29%). Baseline between ECGs was different (p = 0.025) similarly for Short term variability (STV) (p <0.0001). BMI did not differentiate SVT rates. Only high acceleration (p <0.029) and small slowdowns had a statistically significant difference between normal and suspected cardiographs (p <0.029). APGAR score did not differ, whereas the umbilical cord pH was different in normal ECGs compared to the suspect (p = 0.012) and STV was also differentiated. A usability and safety survey was conducted after recording with MONIKA AN24, and the response to whether they would accept recording with the device again, was positive for 96% of the 30 responders. CONCLUSION: The present study shows that the use of electrocardiography in obstetrics allows to draw conclusions about the fetal hematopoiesis and oxygenation status. This method could be clinically applied and be an important tool for further screening in embryos that may be hypoxic and to decide whether to continue with a vaginal or cesarean delivery, thereby achieving the goal of reducing perinatal morbidity and mortality.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe