Granulocytic sarcoma (GS), a rare extramedullary manifestation of acute myeloid leukaemia (AML) has been frequently reported in the skin, orbits, gingiva, maxilla and lymph nodes. GS in the mediastinum is often mistaken...Granulocytic sarcoma (GS), a rare extramedullary manifestation of acute myeloid leukaemia (AML) has been frequently reported in the skin, orbits, gingiva, maxilla and lymph nodes. GS in the mediastinum is often mistaken as lymphoblastic lymphoma or mediastinal germ cell tumour. We presented here three cases of AML with normal cytogenetics who presented with mediastinal masses with superior vena caval (SVC) syndrome. All the three cases summarised in this write-up, received standard AML therapy but had, poor outcome.
Isolated injury to the extrahepatic biliary system after blunt trauma is rare, Complete transection of the common bile duct is also a rare entity. Here a case of a 45-year-old male admitted with the history of blunt trau...Isolated injury to the extrahepatic biliary system after blunt trauma is rare, Complete transection of the common bile duct is also a rare entity. Here a case of a 45-year-old male admitted with the history of blunt trauma abdomen with features of peritonitis and jaundice, found to have complete transection of common bile duct and there was no other visceral injury is reported. Cases of isolated complete transection of common bile duct in blunt trauma abdomen are rarely reported in the literature.
Renal allograft rupture is defined as a renal laceration, which involves two or more surfaces of the graft and extends beyond renal capsule with or without involvement of the collecting system. Acute and hyperacute rejec...Renal allograft rupture is defined as a renal laceration, which involves two or more surfaces of the graft and extends beyond renal capsule with or without involvement of the collecting system. Acute and hyperacute rejections are the causes in most of the cases. Non-rejection aetiologies of graft rupture include acute tubular necrosis, renal vein thrombosis, ureteric obstruction, polyarteritis nodosa, ischaemia, hypertension and biopsy. Early detection of these causes is of prime importance for graft salvage. Here we report an uncommon case of spontaneous renal allograft rupture due to intrarenal ischaemia leading to infarction and hypertensive crisis.
A young male patient was admitted to our hospital with history of dysuria, recurrent vomiting, severe muscle pain and weakness which was induced by a session of rigorous exercise for the first time in the local gymnasium...A young male patient was admitted to our hospital with history of dysuria, recurrent vomiting, severe muscle pain and weakness which was induced by a session of rigorous exercise for the first time in the local gymnasium. He was subsequently diagnosed with exercise-induced acute kidney injury and rhabdomyolysis and managed accordingly. Later on during follow-up he was found to have extreme hypouricaemia (serum uric acid 0.2 mg/dl) and was subsequently diagnosed with renal hypouricaemia. Biochemical investigations on other family members of the patient revealed hereditary renal hypouricaemia in the family.
To find out the safety, effectiveness and tolerability of using desogestrel (75 microg/day), a progesterone only pill on lactating mother, a prospective clinical study was undertaken among 200 lactating women during the...To find out the safety, effectiveness and tolerability of using desogestrel (75 microg/day), a progesterone only pill on lactating mother, a prospective clinical study was undertaken among 200 lactating women during the period from 1st January 2010 to 13th June 2011 at Gice Clinic, Kalyani, Nadia, West Bengal. The same number of cases were taken as placebo for comparison. Desogestrel was started after six weeks of delivery for six months. Patients were reviewed at 8th, 12th, 16th, 24th weeks and one year. The very interesting results were found from the follow-up study that desogestrel (75 microg/day) did not alter the amount and composition of breast milk, pregnancy was not reported as compared to placebo. The drug had good tolerability, less side-effects and did not affect the growth and development of breastfed babies. Due to the safety, good efficacy, tolerability and less side-effects it is concluded that desogestrel (75 microg/day) was well accepted in majority of women (97.5%) and provided good contraceptive efficacy during the lactating period. This treatment does not have any effect on the growth and development of breastfed baby.
Even in the light of newer and less nephrotoxic contrast media solutions, their increased use during standard and new radiological procedures has resulted in the growing incidence of contrast-induced nephropathy, an iatr...Even in the light of newer and less nephrotoxic contrast media solutions, their increased use during standard and new radiological procedures has resulted in the growing incidence of contrast-induced nephropathy, an iatrogenic disorder caused by exposure to contrast media. This retrospective study was conducted among the patients admitted in North Bengal Medical College from January 2007 to December 2010 with significant rise in serum creatinine level within 48 to 72 hours of systemic administration of contrast media. The study sample constituted 14 patients with mean age being 45.2 years. Among them, 10 patients (71.4%) required haemodialysis. One patient (7.1%) expired after receiving three sessions of haemodialysis. Three patients (21.4%) became dependent on haemodialysis. Once developed, contrast induced nephropathy is associated with high morbidity, long hospital-stay and patient becomes dependent on haemodialysis. Till now, no available current treatment can reverse or ameliorate the condition once it develops. Some precautionary measures taken in the high risk patients before administration of contrast medium is essential to reduce the incidence.
Kidneys play a significant role in thyroid hormone metabolism by conversion of thyroxine (T4) to triiodothyronine (T3) and abnormal thyroid function tests are frequently observed in patients of chronic kidney disease. Th...Kidneys play a significant role in thyroid hormone metabolism by conversion of thyroxine (T4) to triiodothyronine (T3) and abnormal thyroid function tests are frequently observed in patients of chronic kidney disease. The aim of present study was to analyse the thyroid function in patients of chronic kidney disease and its correlation with severity of kidney disease. Fifty patients of chronic kidney disease were included. All patients were on conservative management and were divided into 3 groups. Those with creatinine clearance < 7.5 ml/minute were placed in group A (n = 21), with creatinine clearance 7.5 - 15 ml/minute in group B (n = 21) and with creatinine clearance > 15 ml/minute in group C (n = 8). Thyroid profile was studied in all patients. The results were compared to age and sex matched healthy controls. Thirty-five patients (70%) of chronic kidney disease were found to be having abnormal thyroid functions. The mean values of serum total T3, free T3, total T4, free T4 were significantly reduced and that of thyroid stimulating hormone (TSH) were significantly higher in cases as compared to controls and these abnormities in thyroid function test increased as the creatinine clearance decreased (from group C to group A). It is concluded that thyroid dysfunction occurs in patients with chronic kidney disease. Mean values of TT3, FT3, TT4, FT4 reduced and that of TSH increased as severity of renal failure increased.
To evaluate the efficacy of placentrex injection along with oral doxycycline against oral doxycycline in pelvic inflammatory diseases, a comparative study was undertaken among two groups of patients comprising 60 in each...To evaluate the efficacy of placentrex injection along with oral doxycycline against oral doxycycline in pelvic inflammatory diseases, a comparative study was undertaken among two groups of patients comprising 60 in each at Pt BD Sharma Postgraduate Institute of Medical Sciences, Rohtak during the period April 2010 to April 2012. It was observed remission of symptoms and signs was better noticed among the group of patients receiving placentrex + doxycycline than those getting only doxycycline. Placentrex is safe with less side-effects and inexpensive.