BMC Ophthalmol
· 2026 Jun · PMID 42288741
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BACKGROUND: Oculomotor nerve (cranial nerve III) palsy in children and adolescents is uncommon and typically suggests an underlying structural lesion rather than microvascular ischemia. Sphenoid sinus disease represents...BACKGROUND: Oculomotor nerve (cranial nerve III) palsy in children and adolescents is uncommon and typically suggests an underlying structural lesion rather than microvascular ischemia. Sphenoid sinus disease represents a rare cause of ocular cranial neuropathies and most frequently affects the abducens nerve. Consequently, isolated chronic oculomotor nerve palsy secondary to sphenoid sinus pathology is an unusual clinical presentation. CASE PRESENTATION: We report a 16-year-old male who presented with long-standing right ocular deviation and progressive limitation of eye movements beginning in early childhood. Neuro-ophthalmic examination demonstrated severe limitation of adduction, elevation, and depression of the right eye associated with a large-angle exotropia and a fixed dilated pupil, consistent with chronic oculomotor nerve palsy. Notably, no ptosis of the right upper eyelid was observed despite the severity of the motor deficit, a finding that is discussed in the context of divisional and fascicular nerve involvement. The patient had a prior history of a sphenoid sinus lesion treated with functional endoscopic sinus surgery and partial resection. Histopathological examination revealed a histiocyte-rich lesion with surrounding fibrosis. Magnetic resonance imaging obtained during the current evaluation demonstrated postoperative changes with arrested pneumatization of the right sphenoid sinus, with no evidence of residual or recurrent mass lesion, and diffuse fatty atrophy of the right medial and inferior rectus muscles consistent with long-standing denervation. CONCLUSION: This case highlights a rare presentation of chronic isolated oculomotor nerve palsy associated with sphenoid-cavernous sinus pathology in an adolescent. The close anatomical relationship between the sphenoid sinus and the cavernous sinus provides a plausible mechanism for selective involvement of the oculomotor nerve. Early recognition of sphenoid sinus lesions in pediatric patients presenting with unexplained strabismus or cranial nerve deficits is essential to prevent irreversible neuro-ophthalmic sequelae.
Ou Y, Chopra V, Rosdahl JA
… +6 more, Richter GM, Knight OJ, Solá-Del Valle D, Takusagawa HL, Kim SJ, WuDunn D
Ophthalmology
· 2026 Jun · PMID 42287272
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PURPOSE: To review the current published literature on the utility of visual electrophysiology testing in the diagnosis of glaucoma. METHODS: Literature searches of the PubMed database were last conducted in August 2025...PURPOSE: To review the current published literature on the utility of visual electrophysiology testing in the diagnosis of glaucoma. METHODS: Literature searches of the PubMed database were last conducted in August 2025 and restricted to articles published on or after January 1, 2011. The search identified 738 articles that were reviewed in abstract form for relevancy, and 170 were selected for full-text review. After inclusion and exclusion criteria were applied, 37 articles were selected for data abstraction by panel members. A total of 20 studies were selected for inclusion, and the panel methodologist (J.A.R.) assigned each a level of evidence rating. RESULTS: None of these 20 articles were rated level I, 1 article was rated level II, and 19 articles were rated level III. Visual electrophysiology tests, including electroretinography (ERG) and visual evoked potentials (VEP), are objective measures that provide an assessment of visual function. Pattern electroretinography (PERG) may assist the clinician's ability to diagnose early glaucoma before visual field deficits are detected, especially in patients with retinal nerve fiber layer (RNFL) loss as measured by OCT. The photopic negative response (PhNR) of the cone-driven full-field ERG is sensitive to glaucoma damage and has a less strict requirement for lack of media opacity and steady fixation compared with PERG. Visual evoked potentials and multifocal VEP (mfVEP) can discriminate between glaucoma and control eyes, but they are technically challenging to perform, which may limit their adoption for glaucoma diagnosis. CONCLUSIONS: Although significant advances have been made in developing these objective visual electrophysiology tests to discriminate between glaucoma and control eyes, they are not yet recommended in routine clinical evaluation. They may have a role in select scenarios to augment currently accepted structural and functional assessments. Utility is limited because of barriers to widespread clinical implementation, including the lack of consensus on stimulation and analysis protocols with standardized reference ranges. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
Chen W, Chen F, Xie L
… +3 more, Wu C, Ding S, Xiang D
BMC Ophthalmol
· 2026 Jun · PMID 42286519
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BACKGROUND: School-based myopia screening commonly relies on non-cycloplegic refraction because cycloplegic refraction is difficult to implement universally at scale. This study evaluated whether non-cycloplegic spherica...BACKGROUND: School-based myopia screening commonly relies on non-cycloplegic refraction because cycloplegic refraction is difficult to implement universally at scale. This study evaluated whether non-cycloplegic spherical equivalent (NC-SE) could serve as a low-burden first-stage triage metric to identify children who warrant cycloplegic assessment for possible hyperopia reserve insufficiency (HRI). METHODS: This cross-sectional school-based study included 1,650 children aged 6-15 years from Zengcheng District, Guangzhou, China. All participants underwent non-cycloplegic autorefraction, UCVA assessment, and cycloplegic autorefraction. Cycloplegic spherical equivalent (Cyclo-SE) was used as the reference standard for defining HRI, cycloplegic myopia, and pseudomyopia. HRI was operationally defined as preserved UCVA with low cycloplegic hyperopic reserve: Cyclo-SE from 0 to + 1.25 D in children aged 6-8 years and from 0 to + 1.00 D in children aged 9-15 years. Diagnostic performance of NC-SE for identifying HRI was assessed using receiver operating characteristic (ROC) analysis. RESULTS: The prevalence of HRI was 14.1%, 10.5%, and 3.9% in the 6-8, 9-11, and 12-15-year-old groups, respectively. Correlation between NC-SE and Cyclo-SE strengthened with age (Spearman's rho: 0.641, 0.675, and 0.813; all p < 0.001). For detecting HRI, NC-SE achieved an AUC of 0.661 (95% CI: 0.618-0.704). A pragmatic cutoff of -0.50 D yielded a sensitivity of 0.824 (95% CI: 0.765-0.870), specificity of 0.550 (95% CI: 0.524-0.575), PPV of 20.5% (95% CI: 17.9-23.4), and NPV of 95.7% (95% CI: 94.1-96.9). Among children with normal visual acuity, 24.1% had pseudomyopia. CONCLUSION: NC-SE may serve as a low-burden first-stage triage metric in school-based screening to identify children who warrant cycloplegic assessment for possible HRI. However, its moderate AUC and low PPV indicate that NC-SE should not be interpreted as a stand-alone diagnostic test. Cycloplegic refraction remains necessary for confirming hyperopic reserve status. Further longitudinal studies incorporating axial length, accommodative measurements, and external validation are needed to determine its prognostic value for incident myopia. CLINICAL TRIAL NUMBER: Not applicable.
Chacun S, Billant J, Goissaud A
… +8 more, Chirpaz N, Elbany S, Rocher A, Gilli C, Fenniri I, Burillon C, Matagrin B, Dot C
BMC Ophthalmol
· 2026 Jun · PMID 42286485
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OBJECTIVE: To evaluate the long-term effectiveness and safety of selective laser trabeculoplasty (SLT) for controlling intraocular pressure (IOP) in patients with steroid-induced ocular hypertension (OHT) treated with fl...OBJECTIVE: To evaluate the long-term effectiveness and safety of selective laser trabeculoplasty (SLT) for controlling intraocular pressure (IOP) in patients with steroid-induced ocular hypertension (OHT) treated with fluocinolone acetonide (FAc) intravitreal implants. METHODS: This was a single-center retrospective case series of patients with steroid-induced OHT. Eligibility required prior to exposure to ≥ 3 sustained-release dexamethasone intravitreal implants per eye. SLT was performed in all eyes either before (group 1, n = 6), after (group 2, n = 6), or both before and after (group 3, n = 3) the FAc implantation. IOP was analysed with linear mixed-effects models (random intercept for eye). The mean IOP and within-eye variability (SD-IOP) were summarized for the pre-SLT and post-SLT periods. RESULTS: Fifteen eyes from thirteen patients treated for macular edema were followed for 32 ± 17.7 months after SLT. The mean IOP decreased by 14.2 mmHg across the cohort (p < 0,001). In group 1, which was treated with SLT before FAc implantation, the mean IOP decreased from 16.5 ± 4.8 mmHg to 13.7 ± 2.1 mmHg (p < 0.001) with significantly reduced IOP variability (-2.1 mmHg, p < 0.001). No eye required filtering surgery. Steroid-induced OHT resolved in all eyes within ≤ 4 months after the last dexamethasone implant and ≤ 36 months after the FAc implant. CONCLUSION: SLT is a safe, effective, and repeatable intervention for preventing or controlling IOP elevation in OHT responders' eyes receiving FAc implants. Performing SLT prior to FAc injection may offer better IOP control and reduce variability in such patients.
Chen Y, Wang Z, Zhou R
… +7 more, Zhao Y, Liu X, Gou Y, Ren H, Xie B, Li D, Li H
BMC Ophthalmol
· 2026 Jun · PMID 42277757
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BACKGROUND: Percussion massage guns (PMGs) have gained widespread popularity for muscle recovery; however, standardized safety guidelines for application to anatomically vulnerable regions are lacking. Previously reporte...BACKGROUND: Percussion massage guns (PMGs) have gained widespread popularity for muscle recovery; however, standardized safety guidelines for application to anatomically vulnerable regions are lacking. Previously reported PMG-associated ocular injuries have been limited to unilateral or mild bilateral involvement. We report the first documented case of bilateral anterior lens luxation with secondary glaucoma strongly associated with self-application of a PMG to closed eyelids. CASE PRESENTATION: A 62-year-old Chinese male with type 2 diabetes mellitus and bilateral meibomian gland dysfunction presented with progressive visual decline and headache for 20 and 10 days, respectively, beginning approximately 7 days after discontinuing self-application of a PMG to closed eyelids (medium speed, 30-33 Hz; 10 min per session, 2-3 times daily for 3 consecutive days) used to relieve ocular dryness. Visual acuity was 0.12 OD and 0.2 OS, with intraocular pressure 51 mmHg OD and 49 mmHg OS. Ultrasound biomicroscopy revealed bilateral anterior lens luxation with 360° zonular dehiscence and complete angle closure. Hereditary, pseudoexfoliative, and biometric causes (including microspherophakia and phacomorphic glaucoma) were considered unlikely. Both eyes underwent sequential 25-gauge pars plana vitrectomy with lensectomy and closed four-point scleral fixation of a posterior chamber intraocular lens. At the latest follow-up (12 months postoperatively), best-corrected visual acuity was 1.0 OD and 0.8 OS, intraocular pressure was normal without antiglaucoma medication, and no glaucomatous optic neuropathy was detected on RNFL OCT. CONCLUSIONS: PMG application to the eyelids may be associated with severe bilateral ocular injury, including complete zonular dehiscence and secondary glaucoma, particularly in eyes with predisposing factors such as age-related zonular weakness or diabetes-related extracellular matrix changes. Manufacturers should incorporate explicit safety warnings against periorbital use. Clinicians should proactively guide diabetic patients with dry eye disease toward appropriate ophthalmic care to prevent harmful self-treatment.
Ulutaş HG, Birge Ergün M, Gönültaş Özkan EN
… +1 more, Yılmaz S
BMC Ophthalmol
· 2026 Jun · PMID 42277729
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BACKGROUND: The purpose of this study was to evaluate the impact of subepithelial infiltrates (SEIs) developing after adenovirus epidemic keratoconjunctivitis (EKC) on corneal densitometry and biomechanical properties. M...BACKGROUND: The purpose of this study was to evaluate the impact of subepithelial infiltrates (SEIs) developing after adenovirus epidemic keratoconjunctivitis (EKC) on corneal densitometry and biomechanical properties. METHODS: Patients who were followed up for at least six months after an acute EKC episode and had persistent SEI were included in the study. Ophthalmological examination findings, corneal tomographic and densitometric parameters obtained with the Pentacam AXL Wave, and biomechanical measurements acquired with the Corvis ST were recorded. RESULTS: Twenty-three eyes of 12 patients with SEIs after EKC and 32 eyes of 16 healthy controls were analyzed, with no significant differences in age or sex distribution between groups. The EKC group showed worse BCVA, higher K2 and Kmax values, increased total higher-order aberrations (HOAs), and elevated corneal densitometry, predominantly in the anterior and central zones. Among biomechanical parameters, A1-length was significantly lower in the EKC group, whereas the remaining biomechanical and specular microscopy parameters were similar between groups. Within the EKC group, extensive involvement was associated with thinner corneas, greater HOAs, and higher central corneal densitometry values. CONCLUSION: Eyes with persistent SEIs after EKC exhibited increased corneal densitometry, whereas alterations in selected biomechanical parameters were limited. These findings may reflect post-inflammatory corneal remodeling. Because only A1-length remained significantly associated with EKC after multivariable adjustment, the biomechanical findings should be interpreted cautiously. Careful preoperative corneal evaluation is advisable for refractive surgery candidates with persistent SEIs after EKC.
Miyakoshi A, Toyoda N, Katayama H
… +1 more, Hayashi A
BMC Ophthalmol
· 2026 Jun · PMID 42277726
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BACKGROUND: Pterygium progression induces corneal optical distortion, and delayed surgery may limit postoperative recovery of corneal optics. However, quantitative criteria indicating the latest acceptable timing of surg...BACKGROUND: Pterygium progression induces corneal optical distortion, and delayed surgery may limit postoperative recovery of corneal optics. However, quantitative criteria indicating the latest acceptable timing of surgery remain unclear. This study aimed to determine extension-rate thresholds predicting postoperative normalization of corneal asymmetry and higher-order irregularity (HOI). METHODS: This retrospective observational study included 134 eyes with primary pterygium that underwent surgical excision. The pterygium extension rate was calculated from slit-lamp photographs as the ratio of the apex-to-limbus distance to the horizontal corneal diameter. Corneal asymmetry and HOI within the central 3-mm zone were measured preoperatively and 1 month postoperatively using swept-source anterior segment optical coherence tomography. Receiver operating characteristic (ROC) analyses were used to determine cutoff values predicting postoperative normalization. RESULTS: The pterygium extension rate correlated significantly with preoperative corneal asymmetry (r = 0.5899, p < 0.001) and HOI (r = 0.5462, p < 0.001). ROC analysis showed good predictive ability for postoperative corneal asymmetry (AUC 0.80; cutoff 0.359; sensitivity 58.0%, specificity 89.3%) and moderate predictive ability for HOI (AUC 0.74; cutoff 0.292; sensitivity 72.3%, specificity 64.7%). Postoperative normalization occurred in 62.7% of eyes for asymmetry and 38.1% for HOI. CONCLUSIONS: The pterygium extension rate is a simple clinical metric that predicts postoperative optical recovery. These extension-rate thresholds may help support clinical estimation of how long pterygium surgery may be deferred while maintaining the possibility of postoperative optical recovery.
BMC Ophthalmol
· 2026 Jun · PMID 42277682
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BACKGROUND: To evaluate real-world efficacy, durability, and safety of faricimab in treatment-naïve Asian patients with neovascular age-related macular degeneration (nAMD). METHODS: Retrospective study of treatment-naïve...BACKGROUND: To evaluate real-world efficacy, durability, and safety of faricimab in treatment-naïve Asian patients with neovascular age-related macular degeneration (nAMD). METHODS: Retrospective study of treatment-naïve nAMD eyes treated with faricimab at a single centre in South Korea. After four monthly loading doses, treatment intervals (Q8W, Q12W, Q16W) were assigned based on disease activity at weeks 20 and 24. Comprehensive assessments included best-corrected visual acuity (BCVA), central subfield thickness (CST), pigment epithelial detachment (PED) height, subfoveal choroidal thickness (SFCT), and intraretinal/subretinal fluid (IRF/SRF) presence. RESULTS: Eighty-eight treatment-naïve eyes were included. Mean age was 72.8 (9.0) years. At week 20, BCVA improved from 62.1 (15.4) to 69.3 (14.6) ETDRS letters (+ 7.1 letters, P < 0.001). CST decreased from 414 (150) to 280 (94) µm (- 134 μm, P < 0.001). PED height decreased from 297 (167) to 171 (116) µm (- 43%, P < 0.001). SFCT decreased from 208 (91) to 184 (83) µm (- 12%, P < 0.001), with PCV eyes showing the greatest reduction (- 32 μm, P < 0.001). IRF presence (1 mm/6 mm) decreased from 33%/34% to 7%/9%, and SRF from 78%/84% to 12%/20% at week 20. At week 60, 52.3% achieved Q16W and 67.0% achieved ≥Q12W intervals. Among 168 eyes in the safety analysis, there was 1 case of mild vitritis and 2 cases of RPE tear, with no cases of endophthalmitis or retinal vasculitis reported. CONCLUSIONS: Initiation of faricimab in treatment-naïve nAMD patients resulted in favourable visual and anatomical outcomes with durable treatment intervals and a low incidence of adverse events in a real-world setting.
PURPOSE: To describe a novel postoperative optical coherence tomography (OCT) finding following rhegmatogenous retinal detachment (RRD) repair and explore its relationship with retinal displacement. DESIGN: Retrospective...PURPOSE: To describe a novel postoperative optical coherence tomography (OCT) finding following rhegmatogenous retinal detachment (RRD) repair and explore its relationship with retinal displacement. DESIGN: Retrospective consecutive case series. PARTICIPANTS: Patients with primary RRD with partial macular involvement who underwent successful repair. METHODS: Patients after RRD repair who demonstrated a marginal outer retinal ridge (MORR) on postoperative OCT were included. MORR was defined as a linear outer retinal hyperreflective ridge adjacent and parallel to the RRD margin. MAIN OUTCOME MEASURES: Clinical characteristics, surgical variables, multimodal imaging findings, and evidence of retinal displacement were assessed. RESULTS: Twelve eyes were included. MORRs were predominantly located along the inferior RRD margin (11/12) and were detectable as early as postoperative day 1. In 4/12 eyes (33%), MORRs occurred in regions that were attached at presentation. MORRs resolved spontaneously within months in all cases. In two cases, MORR involved the fovea. Retinal displacement was more pronounced superior to a MORR, supporting retinal redundancy as the mechanism of formation. CONCLUSIONS: MORR represents a novel OCT biomarker of retinal displacement and reflects postoperative retinal redundancy. Recognition of MORR provides new insight into the biomechanics of retinal reattachment and may have implications for surgical technique, postoperative imaging, and functional outcomes.
Tusa ES, Tamlander M, Ripatti S
… +5 more, Harju M, Salo K, FinnGen, Turunen JA, Mars N
Ophthalmology
· 2026 Jun · PMID 42276423
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PURPOSE: To investigate the clinical utility of a glaucoma polygenic risk score (PRS) for glaucoma, by benchmarking published glaucoma PRSs and by assessing how the best-performing PRS performs for assessing glaucoma ris...PURPOSE: To investigate the clinical utility of a glaucoma polygenic risk score (PRS) for glaucoma, by benchmarking published glaucoma PRSs and by assessing how the best-performing PRS performs for assessing glaucoma risk, age at onset, and glaucoma prognosis. DESIGN: Cohort study. PARTICIPANTS: 402,739 individuals in FinnGen, with 21,609 individuals with glaucoma diagnosed after the age of 40. MAIN OUTCOME MEASURES: Lifetime risk of glaucoma, the need and escalation of intraocular pressure-lowering medication, need for laser therapies, need for incisional surgery. METHODS: Fourteen published glaucoma PRSs from the PGS Catalog were comprehensively benchmarked using Cox proportional hazards models. The best-performing PRS was selected to further evaluate the lifetime risk of glaucoma by age 85 years using Kaplan- Meier survival analyses, both alone, and alongside family history information. In addition, the impact of PRS on prognostic outcomes was assessed over a 20-year follow-up period. RESULTS: The PRS with the best performance had a hazard ratio (HR) of 3.32 (95% CI, 3.21-3.43) for glaucoma (≥90th PRS percentile vs 20-80th percentile). Lifetime risk of glaucoma increased considerably across PRS categories from 2.5% (95% CI 1.7-3.3%) among individuals in the <1st percentile, to 31.9% (30.5-33.3%) in the 95-99th percentile, and to 45.3% (42.3%-48.1%) in the ≥99th percentile. Family history and PRS contributed independently to glaucoma risk, with the PRS effect size decreasing only by 4.2% when adjusting the PRS effect for FH. Those in the highest PRS decile required more intensive glaucoma care, with higher cumulative incidences of medication escalation (60.6% vs 38.4%), laser therapies (39.8% vs 22.9%), and incisional surgeries (15.8% vs 9.5%) compared to the lowest PRS decile over a 20-year follow-up. CONCLUSIONS: In this large biobank study, a glaucoma PRS effectively stratified individuals according to their lifetime risk of glaucoma, with substantial stratification evident already by midlife. The PRS provided a more precise risk assessment than family history alone, and it was effective in stratifying individuals based on several prognostic measures, including medical treatment escalation and surgical interventions. These findings support the potential utility of PRS-guided screening and management strategies in glaucoma, with future prospective studies warranted to evaluate the clinical implementation and cost- effectiveness.
Çakmak S, Söylemez M, Cebeci Z
… +3 more, Erdogan G, Altınkurt E, Bayraktar Ş
BMC Ophthalmol
· 2026 Jun · PMID 42271301
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PURPOSE: To compare the effectiveness of topical nepafenac 0.1% and 0.3% in the management of pseudophakic cystoid macular edema (PCME) following cataract surgery. METHODS: In this retrospective comparative study, patien...PURPOSE: To compare the effectiveness of topical nepafenac 0.1% and 0.3% in the management of pseudophakic cystoid macular edema (PCME) following cataract surgery. METHODS: In this retrospective comparative study, patients with PCME after cataract surgery and a follow-up of at least three months were included. Patients were assigned to two groups according to the topical nepafenac treatment initiated after PCME diagnosis: 0.1% (Group-1) or 0.3% nepafenac (Group-2). Best-corrected visual acuity (BCVA), macular and choroidal parameters assessed by optical coherence tomography (OCT) were evaluated at diagnosis and during follow-up and were compared between the groups. RESULTS: The study included 97 eyes from 78 patients, with a mean age of 71.3 ± 7.1 years. Baseline demographic characteristics and surgical parameters were comparable between the groups. BCVA, macular and choroidal parameters improved in both groups during follow-up. At the third month, Group-1 showed significantly better mean BCVA (0.056 ± 0.082 vs. 0.122 ± 0.135, p = 0.028). At the first month, mean central foveal subfield thickness was significantly thinner in Group-1 (348.0 ± 96.5 vs. 387.9 ± 130.7, p = 0.047). Mean choroidal vascular index (CVI) increased during follow-up in both groups, with a greater increase observed in Group-2 at the first month (0.5 ± 2.7 vs. 2.1 ± 3.7, p = 0.024). Complete anatomical response at the first month was observed more often in Group-1 (60.0% vs. 38.1%, p = 0.033). CONCLUSION: Topical nepafenac 0.1% and 0.3% were both associated with improvement in PCME. Group-1 showed better early anatomical and later visual outcomes, whereas Group-2 showed a greater early CVI increase. However, these findings do not establish the superiority of either regimen.
BMC Ophthalmol
· 2026 Jun · PMID 42271300
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BACKGROUND: Usher syndrome is an autosomal recessive disorder characterized by retinitis pigmentosa (RP), sensorineural hearing loss, and vestibular dysfunction. Polypoidal choroidal vasculopathy (PCV) is characterized b...BACKGROUND: Usher syndrome is an autosomal recessive disorder characterized by retinitis pigmentosa (RP), sensorineural hearing loss, and vestibular dysfunction. Polypoidal choroidal vasculopathy (PCV) is characterized by branching neovascular networks and polypoidal lesions. While typically classified within the pachychoroid spectrum, PCV can also manifest in eyes without choroidal thickening. Conversely, RP is usually associated with choroidal thinning, which may lead to underdiagnosis of PCV. To the best of our knowledge, PCV has not previously been reported in patients with Usher syndrome. Here, we present the first genetically confirmed case of Usher syndrome type 2 complicated by PCV that was successfully managed with intravitreal faricimab. CASE PRESENTATION: A 63-year-old man presented with night blindness. The diagnosis of Usher syndrome type 2 was confirmed based on bilateral RP features, moderate sensorineural hearing loss, and two pathogenic USH2A variants. Six years after the initial diagnosis, the patient developed visual disturbance in the left eye, with the best-corrected visual acuity (BCVA) declining to 20/80. Multimodal imaging, including spectral-domain optical coherence tomography, fluorescein angiography, indocyanine green angiography, and swept-source optical coherence tomography angiography, confirmed the diagnosis of PCV. An amelanotic choroidal nevus was also identified on SD-OCT. After five intravitreal faricimab injections, the BCVA improved to 20/30, with a 75% reduction in pigment epithelial detachment height and complete subretinal fluid resolution without adverse effects. CONCLUSIONS: To our knowledge, this is the first reported case of PCV associated with a choroidal nevus in a patient with genetically confirmed Usher syndrome type 2. PCV should not be excluded in patients with RP despite characteristic choroidal thinning. Intravitreal faricimab was effective and well-tolerated, suggesting its therapeutic potential in such cases.