International Journal Of Clinical And Experimental Medicine[JOURNAL]
Sun
200 papers
Application of flash dual-source CT at low radiation dose and low contrast medium dose in triple-rule-out (tro) examination.
Chen HL, Chen TW, Qiu LH … +3 more , Diao XM, Zhang C, Chen L
Int J Clin Exp Med · 2015 · PMID 26885160
OBJECTIVE: To evaluate the clinical imaging capacity of FLASH dual-source CT at low radiation dose and low contrast medium dose in thoracic aorta, pulmonary artery & vein and coronary artery. METHOD: One hundred and eigh...
OBJECTIVE: To evaluate the clinical imaging capacity of FLASH dual-source CT at low radiation dose and low contrast medium dose in thoracic aorta, pulmonary artery & vein and coronary artery. METHOD: One hundred and eight patients of thoracalgia were randomly divided into two groups; 60 cases (group A) received dual-source CT scan in flash model at 100 KV and contrast medium dose of 74 ml combined with digital subtraction angiography (DSA) examination; 48 cases (group B) received retrospectively. ECG-triggered high-pitch spiral acquisition at 120 KV and contrast medium dose of 101 ml. Several image reconstruction techniques were adopted for coronary artery, pulmonary artery and aorta. The imaging quality and the diagnostic value of this technique were evaluated. Coronary artery stenosis of group A was compared against the results of DSA examination. RESULTS: The scan time in group A was obviously shorter than that of group B, i.e., t=0.7±0.1 s in group A and t=7.7±1.7 s in group A. The image reconstruction phase of coronary artery was 70.4±15.6% in group A, and the systolic phase accounted for 13.3% of the optimal reconstruction phase. Compared with group B, the radiation dose of group A decreased obviously, i.e. ED=2.7±0.7 mSv for group A and ED=21.6±6.0 mSv for group B. Moreover, less contrast agent was consumed in group A than in group B, which was 74 ml in group A and 101 ml in group B. The image quality of aorta and pulmonary artery & vein was grade 1 for all cases in group A, which was the same as with group B. The coronary artery images of group A had better quality, with score of 2.9±0.1. Of 780 segments, only 2 segments could be effectively diagnosed, showing no statistically significant differences from group B (P>0.05). The coronary artery stenosis revealed by dual-source CT for group A was not significantly different from that by DSA (P>0.05). CONCLUSION: FLASH dual-source CT scan at reduced radiation dose and reduced contrast medium dose used for triple-rule-out (TRO) examination achieved good image quality and clear visualization of blood vessels. Moreover, this CT scan technique is fast and rapid in diagnosis and suitable for extensive clinical settings.
Tooth loss and risk of oral squamous cell carcinoma in Chinese Han population.
Zuo C, Zhu Y, Wang X … +2 more , Zeng X, Huang C
Int J Clin Exp Med · 2015 · PMID 26885159
OBJECTIVE: Association between tooth loss and oral cancer risk was investigated primary studies and meta-analyses, however, the results remain inconsistent. This study is to test the association between tooth loss and or...
OBJECTIVE: Association between tooth loss and oral cancer risk was investigated primary studies and meta-analyses, however, the results remain inconsistent. This study is to test the association between tooth loss and oral squamous cell carcinoma (OSCC) in Chinese Han population. METHODS: Case-control study including histologically confirmed OSCC cases and healthy controls individually matched to the cases for age, sex, and district of residence between May 1, 2010, and Match 31, 2014. Univariate and multiple logistic regression models were used to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) using the STATA 12.0 software. RESULTS: Finally included 150 OSCC patients and 167 healthy controls. Cases had a significantly higher mean (SD) number of lost teeth than controls (10.03±6.62 vs. 8.69±5.20; P = 0.045). The results of univariate analysis and adjustment for smoking and alcohol showed a non-significant association between tooth loss and OSCC. After adjustment for age at diagnosis, gender, smoking, alcohol use, body mass index, and history of diabetes mellitus, those in the upper tertiles of lost tooth were significantly more likely to have OSCC (OR = 3.64, 95% CI = 1.15-11.53, P = 0.03; P for trend = 0.11) than in the lower tertiles. The unadjusted and adjusted results of per teeth also revealed non-significant association. CONCLUSIONS: Tooth loss may be not associated with risk of oral cancer in this case-control study. The relevant large-scale studies in Chinese are suggested to perform.
Association of transforming growth factor-β1 polymorphisms with the risk of diabetes mellitus.
Mao S, Zhang J, Zhao M … +1 more , Zhang Y
Int J Clin Exp Med · 2015 · PMID 26885158
The association between transforming growth factor-β1 (TGF-β1) polymorphisms with the risk of diabetes mellitus (DM) remains elusive. We aimed to evaluate the relationship between TGF-β1 polymorphisms and DM risk. We sea...
The association between transforming growth factor-β1 (TGF-β1) polymorphisms with the risk of diabetes mellitus (DM) remains elusive. We aimed to evaluate the relationship between TGF-β1 polymorphisms and DM risk. We searched the association studies according to a predefined criteria using electronic databases. The strength of association between TGF-β1 codon 10/25 polymorphisms and the risk of DM was evaluated by odds ratio (OR) with the corresponding 95% confidence interval (CI). Six case-control studies were identified for the analysis of the association between TGF-β1 codon 10/25 polymorphism and the risk of DM. CC genotype at the codon 10 polymorphism was associated with the risk of type 2 DM (T2DM) (P = 0.026, OR = 1.397, 95% CI = 1.041-1.874). No marked association was observed between codon 25 polymorphism and the risk of DM. No evidence of marked publication bias was observed. CC genotype at the TGF-β1 codon 10 site may be an indicator for the risk of T2DM. However, further larger studies should be performed in the future.
Is there any difference in survivorship of total hip arthroplasty with different bearing surfaces? A systematic review and network meta-analysis.
Yin S, Zhang D, Du H … +3 more , Du H, Yin Z, Qiu Y
Int J Clin Exp Med · 2015 · PMID 26885157
PURPOSE: Although many total hip bearing implants are widely used all over the world, simultaneous comparisons across the numerous available bearing surfaces are rare. The purpose of this study was to compare the survivo...
PURPOSE: Although many total hip bearing implants are widely used all over the world, simultaneous comparisons across the numerous available bearing surfaces are rare. The purpose of this study was to compare the survivorship of total hip arthroplasty (THA) with six available bearing implants. METHODS: We conducted a systematic review of randomized controlled trials (RCTs) reporting survivorship or revision of ceramic-on-ceramic (CoC), ceramic-on-conventional polyethylene (CoPc), ceramic-on-highly-crosslinked polyethylene (CoPxl), metal-on-conventional polyethylene (MoPc), metal-on-highly-crosslinked polyethylene (MoPxl), or metal-on-metal (MoM) bearing implants. The synthesis of present evidence was performed by both the traditional direct-comparison meta-analysis and network meta-analysis. RESULTS: In total, 40 RCTs involving a total of 5321 THAs were identified. The pooled data of network meta-analysis showed no difference in relative risk (RR) of revision across CoC, CoPc, CoPxl and MoPxl bearings. However, the MoM bearing was demonstrated with a significant higher risk of revision compared with CoC (RR 5.10; 95% CI=1.62 to 16.81), CoPc (RR 4.80; 95% CI=1.29 to 17.09), or MoPxl (RR 3.85; 95% CI=1.16 to 14.29), and the MoPc bearing was indicated with a higher risk of revision compared with CoC (RR 2.83; 95% CI=1.20 to 6.63). The ranking probabilities of the effective interventions also revealed the inferiority of the MoM and MoPc implants in survivorship (both 0%, 95% CI=0% to 0%) compared with CoC (39%, 95% CI=0% to 100%), CoPc (33%, 95% CI=0% to 100%), CoPxl (7%, 95% CI=0% to 100%) or MoPxl (21%, 95% CI=0% to 100%). CONCLUSIONS: The present evidence indicated the similar performance in survivorship among CoC, CoPc, CoPxl and MoPxl bearing implants, and that all likely have superiority compared with the MoM and MoPc bearing implants in THA procedures. Long-term RCT data are required to confirm these conclusions and better inform clinical decisions.
The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model.
Ibrahim RY, Hassan AI, Al-Adham EK
Int J Clin Exp Med · 2015 · PMID 26885156
This study aimed to evaluate the anti-inflammatory effects of Annona squamosa (A. squamosa) leaf aqueous extract against acetic acid induced colitis in rats with a trial to explore its use for the treatment of colon infl...
This study aimed to evaluate the anti-inflammatory effects of Annona squamosa (A. squamosa) leaf aqueous extract against acetic acid induced colitis in rats with a trial to explore its use for the treatment of colon inflammation. Sprague Dawley rats weighing 180-200 g were used in this study. Treatment with A. squamosa extract at dose 300 mg/kg for 4 weeks counteracted acetic acid induced ulcerative colitis by a significant decrease (P<0.05) of colonic tissue of malondialdehyde (MDA) and significant increases of catalase (CAT), glutathione (GSH) and glutathione peroxidase (Gpx) compared to ulcerative colitis control group. Furthermore, induction of oxidative stress was observed in the colonic tissue through the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) which significant increase in colonic tissue DNA by acetic acid. Moreover AA induced significant increase in serum interleukin-10 (IL10), tumor necrosis factor-α (TNF-α), transforming growth factor (TGF 1β), and C reactive protein (CRP) as compared to the control group. On the contrary, our results showed AA induced significant decrease of vascular endothelial growth factor (VEGF) and thyroid hormones triiodothyronin and thyroxin (T3 & T4) in installed group with AA as compared to control which significantly improved after treatment with A. squamosa leaf extract. Histopathological observation in our study confirmed the biochemical study. Thus, therapeutic method offer a sign to analyze further the effectiveness of A. squamosa as a unique agent for alleviating colitis.
Clinical significance of urothelial carcinoma associated 1 in colon cancer.
Tao K, Yang J, Hu Y … +6 more , Sun Y, Tan Z, Duan J, Zhang F, Yan H, Deng A
Int J Clin Exp Med · 2015 · PMID 26885155
This study aimed to investigate the expression levels of urothelial carcinoma associated 1 (UCA1) in cancer tissues and plasma of colon cancer patients, and evaluate its clinical significance. Quantitative real-time PCR...
This study aimed to investigate the expression levels of urothelial carcinoma associated 1 (UCA1) in cancer tissues and plasma of colon cancer patients, and evaluate its clinical significance. Quantitative real-time PCR was used to determine the expression levels of UCA1 in 80 pairs of colon cancer and adjacent normal tissues, plasma samples from 20 healthy controls, 20 colon cancer patients before and after tumor removal. The relationships between UCA1 expression and clinical features and overall survival were analyzed. Compared with adjacent normal tissues, UCA1 was significantly upregulated in colon cancer tissues, especially in cases with LNM and advanced TNM stages (P < 0.05). High UCA1 expression was associated with LMN, higher pT category, and advanced TNM stages (P < 0.05). Patients with high UCA1 expression had worse survival time than those with low UCA1 expression (adjusted HR = 2.002, 95% CI 1.007-3.981, P = 0.048). Furthermore, plasma levels of UCA1 in colon cancer patients were significantly higher than those of controls (P = 0.016). There was significant difference in plasma level of UCA1 between samples taken before and after surgery (P = 0.048). In conclusion, tissue expression of UCA1 is related to prognosis in colon cancer. Plasma UCA1 may serve as a potential biomarker for early diagnosis and disease monitoring of colon cancer patients.
Effects of two kinds of radio frequency ablations on morphology and function of left atrium in patients with atrial fibrillation.
Lin G, Yang XJ
Int J Clin Exp Med · 2015 · PMID 26885154
OBJECTIVE: This study aims to observe the effects of circumferential pulmonary vein ablation (CPVA) and CPVA combined with complex fractionated atrial electro-gram (CPVA+CFAE) on morphology and function of left atrium in...
OBJECTIVE: This study aims to observe the effects of circumferential pulmonary vein ablation (CPVA) and CPVA combined with complex fractionated atrial electro-gram (CPVA+CFAE) on morphology and function of left atrium in patients with atrial fibrillation (AF). METHODS: To evaluate the effects of CPVA and CPVA+CFAE on morphology and function of left atrium, the left atrial volume and late diastolic velocity peak (Va) were determined by tissue Doppler imaging before and after CPVA and CPVA+CFAE, respectively. RESULTS: There was no statistical difference in the left atrial volume before and after CPVA. However, Va was significantly higher after CPVA (P=0.001). There was no statistical difference in both the left atrial volume and Va before and after CPVA+CFAE. Va after ablation was significantly higher in CPVA group than in CPVA+CFAE group (P=0.031). CONCLUSION: The left atrial function was significantly improved after CPVA, but CPVA+CFAE failed to markedly improve the left atrial function. This suggests that excessive atrial substrate ablation may damage the left atrial function.
Astragalus polysaccharide improves cardiac function in doxorubicin-induced cardiomyopathy through ROS-p38 signaling.
Zhou L, Chen L, Wang J … +1 more , Deng Y
Int J Clin Exp Med · 2015 · PMID 26885153
Doxorubicin (DOX) is widely used as an antitumor agent, but it is significantly challenged by clinical workers due to the severe and acute cardiotoxitity. Astragalus polysaccharide (APS) is characterized by an anti-infla...
Doxorubicin (DOX) is widely used as an antitumor agent, but it is significantly challenged by clinical workers due to the severe and acute cardiotoxitity. Astragalus polysaccharide (APS) is characterized by an anti-inflammation and anti-oxidant features. In the current study, we explored the effects and specific mechanisms of APS on DOX-induced-cardiomyopathy in mouse primary myocardial cells. To explore the effect of DOX on ROS production, DHE staining and flow cytometry analysis were used in primary cardiomyocytes treated with 1 μM DOX for 24 h. MTT assay was applied to determine the effect of DOX on cell viability. The effects of DOX on rat cardiomyocytes apoptosis by Hoechst staining and annexin V-PI staining, while caspase3 activity was determined using an assay kit. Two-dimensional echocardiography of rats was performed to determine left ventricular fraction and relative wall thickness. Activation of p38 and Akt was analyzed using western blot. ROS production was significantly enhanced by DOX stimulation in primary cardiomyocytes. DOX reduced rat cardiomyocytes viability in a time- and dose-dependent manner. DOX induced apoptosis in rat cardiomyocytes via activation of caspase-3. Cardiac function was significantly impaired by enhanced p38 activation. APS treatment reduced DOX-induced rat cardiomyocytes apoptosis by decreasing ROS production. To conclude, APS reduced DOX-induced cell apoptosis and ROS production by reduced activation of p38 signaling pathway.
Post-neurosurgical meningitis caused by acinetobacter baumannii: case series and review of the literature.
Ni S, Li S, Yang N … +4 more , Zhang S, Hu D, Li Q, Lu M
Int J Clin Exp Med · 2015 · PMID 26885152
BACKGROUND: Acinetobacter baumannii (A. baumannii), a gram-negative bacterium, has now become an important hospital pathogen, which causes various serious nosocomial infections worldwide. Bacterial meningitis is a common...
BACKGROUND: Acinetobacter baumannii (A. baumannii), a gram-negative bacterium, has now become an important hospital pathogen, which causes various serious nosocomial infections worldwide. Bacterial meningitis is a common complication after neurosurgical operation, and the percentage of A. baumannii meningitis is growing, especially the one resisting multiple drugs. METHOD: We retrospectively reviewed the cases with postoperative A. baumannii meningitis (PABM) in the First Affiliated Hospital of Wenzhou Medical University from January 2013 to October 2014. And we retrieved the PubMed for cases with PABM and reviewed them. RESULT: Five cases were included in our retrospective study. Two cases with sensitive A. baumannii and one with multidrug-resistant acinetobacter baumannii (MRAB) were cured, and other two with MRAB died. CONCLUSION: Intraventricular or intrathecal colistin could be a treatment to the MRAB.
Prostatic melioidosis rarely reported in China: two cases report and literatures review.
Tan G, Li J, Chen L … +4 more , Chen X, Zhang S, Ke L, Liu J
Int J Clin Exp Med · 2015 · PMID 26885151
Melioidosis is a fatal, endemic disease caused by Burkholderiapseudomallei which is a gram-negative bacillus. Melioidosis present diversely that ranging from chronic disease to fulminant sepsis, and may affect almost any...
Melioidosis is a fatal, endemic disease caused by Burkholderiapseudomallei which is a gram-negative bacillus. Melioidosis present diversely that ranging from chronic disease to fulminant sepsis, and may affect almost any organ in the body. And in China, melioidosis presenting primarily as prostatic abscesses has rarely been reported. Rapid and accurate diagnostics are needed for melioidosis as the clinical presentation is nonspecific and treatment requires specific antibiotics. Here, we report the clinic features of two cases of prostatic melioidosis that we had cured during 1995 to 2015 and discuss its diagnosis and specific treatment.
Parathyroid adenoma causing a spontaneous cervical and mediastinal massive hematoma.
Zhao C, Wang X, Wei H … +1 more , Ma G
Int J Clin Exp Med · 2015 · PMID 26885150
Cervical and mediastinal hemorrhaging caused by a spontaneous rupture of a parathyroid adenoma has been rarely reported. Herein, we report a case of a 52-year-old woman who experienced a sudden onset of cervical and medi...
Cervical and mediastinal hemorrhaging caused by a spontaneous rupture of a parathyroid adenoma has been rarely reported. Herein, we report a case of a 52-year-old woman who experienced a sudden onset of cervical and mediastinal bleeding related to a parathyroid adenoma. The patient had a history of trauma to the left thorax with a fracture of two ribs. Ultrasonography and computer tomography revealed a nodule in the retrotracheal space and hematoma of the bilateral trachea and thorax. Laboratory examinations revealed significant hypercalcemia, hypophosphatemia, and a high level of intact parathyroid hormone. Surgery was performed and a dark-red, soft tumor was found behind the trachea, which adhered to the surrounding tissues. The pathological diagnosis was a parathyroid adenoma with hemosiderin deposition and fibrosis.
Pulmonary sequestration: a case report and literature review.
Qian X, Sun Y, Liu D … +3 more , Wu X, Wang Z, Tang Y
Int J Clin Exp Med · 2015 · PMID 26885149
PURPOSE: Pulmonary sequestration (PS) is a rare congenital lung malformation. It is characterized by an abnormal mass of dysplastic lung tissue supplied by an anomalous systemic artery and separated from normal bronchopu...
PURPOSE: Pulmonary sequestration (PS) is a rare congenital lung malformation. It is characterized by an abnormal mass of dysplastic lung tissue supplied by an anomalous systemic artery and separated from normal bronchopulmonary tree. Misdiagnosis and inadequate treatment can lead to recurrent pneumonia and fatal hemoptysis. METHODS: We report a 45 years female was diagnosed PS, and performed a brief review about the clinical features, diagnostic strategies, and management options of the PS. RESULTS: Her remarkable symptoms were cough and hemoptysis, the contrast- enhanced computed tomography of the chest revealed a multiloculated cystic solid mass filled with low density lesions and a feeding artery from the descending abdominal aorta to the cystic solid mass was visualized, then the patient suffered a right lower- lobe resection, and the surgery and pathological examination all supported the diagnosis of intralobar sequestration. CONCLUSIONS: Symptomatic patients of the pulmonary sequestration should be treated by surgery to avoid the risk of death due to massive hemoptysis.
Stent-assisted mechanical recanalization for symptomatic subacute or chronic middle cerebral artery occlusion.
Guo D, Ma J, Li TF … +3 more , Zhu M, Han XW, Shui SF
Int J Clin Exp Med · 2015 · PMID 26885148
To assess the feasibility and short-term effects of treating patients with subacute or chronic middle cerebral artery (M1) occlusion by stent-assisted mechanical recanalization. Six patients with cerebral arteries occlus...
To assess the feasibility and short-term effects of treating patients with subacute or chronic middle cerebral artery (M1) occlusion by stent-assisted mechanical recanalization. Six patients with cerebral arteries occlusion underwent surgery. Six cerebral arteries occlusion in 5 patients were successfully recanalized. On postoperative day 1, four patients' symptoms were relieved and two patients' symptoms were exacerbated, of which one was significantly improved after 3 days, the other one's symptoms were recovered to preoperative levels in 2 weeks. No patients died after surgery. No stroke or transient ischemic attack occurred. The average follow-up of was 4.2 months, no worsening of condition, recurrence or death occurred. The results indicate that for patients with subacute or chronic middle cerebral artery (M1) occlusion, mechanical recanalization was technically feasible under the premise of strict case screening. Mechanical recanalization is able to improve ischemic symptoms and promote dysfunction restoration. But its long-term effect remains to be evaluated by further large samples, long-term follow-up studies.
Tumors and pseudotumors at the temporomandibular joint region in pediatric patients.
Wei WB, Chen MJ, Yang C … +2 more , Qiu Y, Zhou Q
Int J Clin Exp Med · 2015 · PMID 26885147
OBJECTIVE: To describe the clinical manifestations and types of, and our surgical experience with, neoplasms in the region of the temporomandibular joint (TMJ) in pediatric patients. MATERIALS AND METHODS: From September...
OBJECTIVE: To describe the clinical manifestations and types of, and our surgical experience with, neoplasms in the region of the temporomandibular joint (TMJ) in pediatric patients. MATERIALS AND METHODS: From September 1997 to December 2013, a total of 18 patients with neoplasms in the region of the TMJ were treated at our department. They all underwent open surgeries. The clinical manifestations and radiological aspects of all the patients were reviewed. The average follow-up period was 61.8 months with a range of 12-221 months. We reviewed the history, physical examination, images, and related radiological examinations. RESULTS: Of the 18 patients, 14 had benign tumors or pseudotumors, and four had malignant tumors. The ratio of pseudotumor to benign tumor to malignant tumor was 2.5:1:1. Limitations of mouth opening were more likely to occur with malignant tumors, and facial deformity had a higher incidence in benign tumors. Local resection was the first choice for patients with benign tumors or pseudotumors. All patients with malignant tumors underwent whole-tumor resection along the boundary, including the joint capsule, disc, and part of the temporal bone and mandible. During the follow-up period, no tumor reformation or new deformity was detected. CONCLUSIONS: In the diagnosis of masses in the TMJ region, CT and MRI play an important role. Surgical removal of the mass with/without joint attachment was sufficient to treat benign and malignant tumors.
Severe hydrocephalus complicated with benign paroxysmal positional vertigo: one case report.
Chen JJ, Cheng WJ, Rao J … +2 more , Lu YF, Qiu WW
Int J Clin Exp Med · 2015 · PMID 26885146
In this study, we reported one female patient diagnosed with severe hydrocephalus who presented with benign paroxysmal positional vertigo (BPPV). She presented with progressive headache and dizziness prior to hospitaliza...
In this study, we reported one female patient diagnosed with severe hydrocephalus who presented with benign paroxysmal positional vertigo (BPPV). She presented with progressive headache and dizziness prior to hospitalization as chief complaints. She received Diagnostic Dix-Hallpike and Roll tests to make a definite diagnosis. The patient was cured after Gufoni maneuver and did not recur after 6-month follow-up. The diagnostic procedures of this female case prompted that prior to formal treatment, patients developing severe hydrocephalus complicated with BPPV should receive provocative test for positional dizziness, performed by experienced physicians from the Department of neurology and otolaryngology.
Intrahepatic biliary papillomatosis associated with malignant transformation: report of two cases and review of the literature.
Li Z, Gao C, Zhang X … +5 more , He Z, Abm K, Biswas S, Niu J, Niu W
Int J Clin Exp Med · 2015 · PMID 26885145
Biliary papillomatosis (BP) is a rare disease characterized by multiple numerous papillary adenomas in both the intrahepatic and extrahepatic biliary tree. Due to its high recurrence rate and frequent transformation to m...
Biliary papillomatosis (BP) is a rare disease characterized by multiple numerous papillary adenomas in both the intrahepatic and extrahepatic biliary tree. Due to its high recurrence rate and frequent transformation to malignancy, BP should not be considered a benign disease, and a radical resection with an adequate resection margin is advocated in cases of localized intrahepatic biliary papillomatosis. Since BP is a rare disease and its clinical features and outcomes are not well known, it's really difficult to diagnose the disease before operation. We encountered two cases diagnosed as intrahepatic biliary papillomatosis postoperatively, and herein present the diagnostic difficulties and therapeutic options for this rare disease.
Repair of acute injuries of the lateral ligament complex of the ankle by suture anchors.
Liu XF, Fang Y, Cao ZH … +2 more , Li GF, Yang GQ
Int J Clin Exp Med · 2015 · PMID 26885144
OBJECTIVE: The objective of this study was to investigate the clinical curative effect of stage I repair of acute injuries of the lateral ligament complex of the ankle by the application of suture anchors. METHODS: We re...
OBJECTIVE: The objective of this study was to investigate the clinical curative effect of stage I repair of acute injuries of the lateral ligament complex of the ankle by the application of suture anchors. METHODS: We retrospectively analyzed 18 cases of III degree acute injuries of the lateral ligament complex of the ankle. RESULTS: There were statistically significant differences in preoperative and last follow-up VAS pain scores and AOFAS ankle hind-foot function scores. The X-ray talus displacement values in the anterior drawer test and pressure anteroposterior X-ray talar tilt in the ankle talar tilt test also showed statistically significant differences. Complications occurred in 2 patients, incision surface infection in one, and postoperative lateral dorsal skin numbness in one. All these cases were cured after symptomatic treatment. At the last follow-up all patients' ankle joint activity recovered to their preinjury function levels. CONCLUSION: The application of suture anchors for small incision stage I repair of the lateral collateral ligament of ankle joint degree III injury, can effectively restored the stability of ankle joint, and prevent the occurrence of chronic ankle instability complications. It is effective and feasible for the treatment of ankle joint lateral collateral ligament injuries.
Direct clipping of a blister-like aneurysm in the supraclinoid segment of the internal carotid artery: a clinical analysis of nine cases.
Yu J, Xu B, Guo Y … +1 more , Xu K
Int J Clin Exp Med · 2015 · PMID 26885143
To investigate the method and outcome from direct clipping of a blister-like aneurysm (BBA) of the internal carotid artery supraclinoid segment. This study featured nine BBA patients, including eight females and one male...
To investigate the method and outcome from direct clipping of a blister-like aneurysm (BBA) of the internal carotid artery supraclinoid segment. This study featured nine BBA patients, including eight females and one male. The patients presented subarachnoid hemorrhage (SAH) as the initial symptom and were diagnosed with BBA in the supraclinoid segment through a vascular exam and imaging. During the exam, the internal carotid artery was pressed to block the blood flow, and a transcranial Doppler (TCD) was performed to examine the blood flow in the (BBA) ipsilateral middle cerebral artery. The results showed that the blood flow was reduced by less than 40% in all nine patients. During surgery, a pterional craniotomy was used to fully expose the aneurysm for clipping. While clipping the aneurysm, the arterial wall at the root of the aneurysm was also clipped to improve stability. Intraoperative ultrasonography was performed before and after clipping to examine the blood flow in the parent artery, middle cerebral artery and anterior cerebral artery. Moreover, a TCD was performed within one week after surgery to monitor intracranial blood flow. During BBA clipping, four patients exhibited stenosis of the parent artery, but intraoperative ultrasonography showed adequate blood flow in the anterior cerebral artery and middle cerebral artery. TCD was performed within one week after surgery to examine the blood flow in the middle cerebral artery on the operative side; the TCD showed adequate blood flow. The patients recovered well after surgery and were discharged. Digital subtraction angiography (DSA) or computed tomography angiography (CTA) was performed six to 12 months after the surgery and showed no aneurysm relapse. Moreover, six patients exhibited no stenosis of the parent artery, 20% stenosis was observed in one patient, 30% stenosis was observed in one patient, and 50% stenosis was observed in one patient; none of the patients showed clinical symptoms, and all patients exhibited good collateral circulation. Therefore, if a pre-operative TCD shows adequate compensatory contralateral blood flow in the (BBA) ipsilateral middle cerebral artery after the internal carotid artery is pressed to block the blood flow, then direct clipping of the BBA is a simple and feasible treatment strategy. However, when the aneurysm is clipped, the artery wall at the root of the aneurysm must also be clipped to improve stability. With adequate compensation, partial stenosis of the parent artery is acceptable.
Pre-operative TNM staging of primary colorectal cancer by (18)F-FDG PET-CT or PET: a meta-analysis including 2283 patients.
Ye Y, Liu T, Lu L … +5 more , Wang G, Wang M, Li J, Han C, Wen J
Int J Clin Exp Med · 2015 · PMID 26885142
The aim of the present study was to perform a meta-analysis to assess the diagnostic value of fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET-CT/PET in the pre-operative evaluation of TNM staging in patients with primary...
The aim of the present study was to perform a meta-analysis to assess the diagnostic value of fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET-CT/PET in the pre-operative evaluation of TNM staging in patients with primary colorectal cancer (CRC). The Medline, Embase and Web of Knowledge were searched for studies assessing the diagnostic value of (18)F-FDG PET-CT/PET in the pre-operative evaluation of TNM staging in CRC patients. We pooled the sensitivity, specificity, positive and negative Likelihood ratio (LR+ and LR-) and Diagnostic Odds Ratio (DOR) and constructed summary receiver operating characteristic curves. A total of 28 studies including 2283 CRC patients were analyzed. The pre-operative tumor detecting rate of PET-CT was 95.35%, which was superior to CT (P < 0.05). The pooled sensitivity and specificity of pre-operative T staging by PET-CT/PET was 0.73 (95% CI: 0.65-0.81) and 0.99 (95% CI: 0.98-0.99), which the AUC and Q* were 0.96 and 0.91, respectively. Concerning pre-operative N staging, the pooled sensitivity and specificity of PET-CT/PET were 0.62 and 0.70, which the AUC and Q* were 0.76 and 0.70, respectively. As for M staging, the pooled sensitivity and specificity of PET-CT/PET were 0.91 (95% CI: 0.80-0.96) and 0.95 (95% CI: 0.91-0.98), which the AUC and Q* were 0.96 and 0.91, respectively. (18)F-FDG PET-CT/PET had good performance in the pre-operative tumor detecting rate, T staging and M staging in patients with primary CRC, which might alter the therapeutic strategy. However, the diagnostic value of (18)F-FDG PET-CT/PET in pre-operative N staging in CRC patients was not ideal.
Highly differentiated squamous cell carcinoma arising from a suprapubic cystostomy tract in a patient with transplanted kidney.
Zhang X, Mi Y, Wang D … +3 more , Yuan X, Zhang B, Bai T
Int J Clin Exp Med · 2015 · PMID 26885141
Squamous cell carcinoma arising from a suprapubic cystostomy tract (SCC-SCT) is a relatively rare bladder malignancy. We present a case of highly differentiated SCC-SCT involving the bladder in a 61-year-old patient with...
Squamous cell carcinoma arising from a suprapubic cystostomy tract (SCC-SCT) is a relatively rare bladder malignancy. We present a case of highly differentiated SCC-SCT involving the bladder in a 61-year-old patient with transplanted kidney. Abdominal magnetic resonance imaging revealed an anomalous mass (8 cm × 6 cm × 5 cm) surrounding the suprapubic cystostomy and a space-occupying lesion in the bladder. The pathology report revealed highly differentiated SCC. The patient received radiation therapy after he refused aggressive surgical management in 2012. There was no evidence of metastasis at his latest follow-up in early 2015.
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