Journal Of Pediatric And Adolescent Gynecology[JOURNAL]
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200 papers
Multi-Site Pain During Menstruation in Adolescents is Associated With Impaired Functioning Across Various Domains: A Cross-Sectional Observational Study.
Seidman LC, Payne LA
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41109475 · Publisher ↗
STUDY OBJECTIVE: To evaluate multi-site pain (i.e., number of painful body regions) during menstruation in a sample of adolescents, and to assess relationships between multi-site pain during menstruation and other menstr...
STUDY OBJECTIVE: To evaluate multi-site pain (i.e., number of painful body regions) during menstruation in a sample of adolescents, and to assess relationships between multi-site pain during menstruation and other menstrual cycle, pain, and psychosocial factors. METHODS: Participants in this cross-sectional observational study included 141 girls ages 13-19 years with varying levels of menstrual pain. Participants indicated on a body map the areas where they usually experience pain when menstruating. Participants also completed a set of validated self-report questionnaires. Menstruation-associated multi-site pain was calculated as the total number of body regions reported (out of 21). Partial correlations controlling for baseline menstrual pain intensity were conducted between menstruation-associated multi-site pain and other variables of interest. RESULTS: The average number of body regions reported was 2.8 (SD = 1.5; min = 0; max = 8). Menstruation-associated multi-site pain was significantly positively correlated with number of pre-menstrual syndrome symptoms, non-menstrual multi-site body pain, pain interference over the prior week, fatigue, sleep disturbance, somatization, and multisensory sensitivity. Menstruation-associated multi-site pain was not significantly correlated with age, age at menarche, gynecologic age, menstrual pain interference, and non-menstrual body pain intensity. CONCLUSION: Pain during menstruation in adolescents is not limited to the abdominal and pelvic regions, and many girls experience pain in numerous body locations during their periods. The associations between menstruation-associated multi-site pain and other pain and psychosocial measures provide preliminary evidence for the existence of a sub-group of adolescents who may be at increased risk for future pain problems.
Age-related Trends and 30-day Postoperative Complications in Variations in Sex Characteristic-related Procedures: A National Surgical Quality Improvement Program Study.
Grimstad F, Scatoni A, Boskey ER
J Pediatr Adolesc Gynecol · 2026 Apr · PMID 41106770 · Publisher ↗
STUDY OBJECTIVE: The goal of this study was to describe the age ranges in which common genital, gonadal, and reproductive variations in sex characteristic (VSC)-related procedures are done and evaluate the variability in...
STUDY OBJECTIVE: The goal of this study was to describe the age ranges in which common genital, gonadal, and reproductive variations in sex characteristic (VSC)-related procedures are done and evaluate the variability in 30-day postoperative complications based on age range to address ongoing uncertainties about optimal surgery age for VSCs. METHODS: This was a retrospective cohort study utilizing data from the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (NSQIP-P) database from 2012 to 2021. Included cases had a postoperative diagnosis associated with a VSC condition. Descriptive analyses were used. Fisher's exact test was used to test differences in complication risk. RESULTS: Our final analysis included 48,227 cases. Most cases were performed on individuals under the age of 3. When comparing the risk of any short-term, surgical complication by age category for each procedure, only three had significant age differences: ureter/bladder procedures had a higher risk of complications when performed in individuals under 11, and urethral/hypospadias surgeries and scrotoplasties had higher complication rates when performed in those 11 or older. In NSQIP-P, over 5 times as many vaginoplasties and clitoroplasties were performed under the age of 3 as over the age of 11. There were no differences across age groups for any assessed type of complication in either vaginoplasties or clitoroplasties. CONCLUSION: There were few variations seen in NSQIP-P-assessed complications by age at the time of surgeries performed for VSCs, including in vaginoplasties and clitoroplasties. Many later surgeries do not appear to result in significantly worse intraoperative and 30-day postoperative outcomes.
A Scoping Review of Barriers to Accessing Abortions among Adolescents in the United States.
Maslowsky J, Thyden NH, Odom-Konja R … +5 more , Gimbrone C, Paul J, Esbrook E, Hanneke R, Lindberg LD
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41075970 · Full text
STUDY OBJECTIVE: Even before the Dobbs Supreme Court decision, minors experienced a wide variety of barriers to abortion care in the United States, including legal, financial, cultural, transportation, and misinformation...
STUDY OBJECTIVE: Even before the Dobbs Supreme Court decision, minors experienced a wide variety of barriers to abortion care in the United States, including legal, financial, cultural, transportation, and misinformation barriers as well as pressure from parents and partners. This scoping review summarizes the literature on barriers to abortion among minors in the United States prior to the Dobbs decision. METHODS: We conducted a database search to identify original research in the United States published between 2007 and 2022. We included quantitative and qualitative empirical articles and assessed their quality. We created categories for the barriers to abortion among minors identified in the articles. We screened 7584 records and included 70 articles in the scoping review. We charted study aims, study designs, data sources, analytic samples, and results. RESULTS: The articles explored factors related to abortion access and identified several categories of barriers to abortion among minors. These included legal barriers (41 articles found them to be a barrier), financial barriers (14 articles), cultural barriers (13 articles), transportation barriers (12 articles), pressure from parents (11 articles), misinformation (8 articles), and pressure from a partner (8 articles). Legal barriers, including laws that require minors to inform or get permission from an adult guardian, were the most commonly identified barrier. CONCLUSION: These findings suggest that minors need policy and interpersonal support to overcome general and age-specific barriers to abortion care. Future research should examine if and how barriers for minors have intensified post-Dobbs, informing targeted policy responses.
Cyclic Gastrointestinal Symptoms Induced by Selective Serotonin Reuptake Inhibitors: A Case Report of Menstruation-related Adverse Effects.
Sungur I, Kuman Tunçel Ö, Hortu I
J Pediatr Adolesc Gynecol · 2026 Apr · PMID 41072719 · Publisher ↗
BACKGROUND: Gastrointestinal adverse effects are common with selective serotonin reuptake inhibitors (SSRIs), yet menstruation‑specific cyclic gastrointestinal symptoms have not been described. OBJECTIVE: This report des...
BACKGROUND: Gastrointestinal adverse effects are common with selective serotonin reuptake inhibitors (SSRIs), yet menstruation‑specific cyclic gastrointestinal symptoms have not been described. OBJECTIVE: This report describes, to the best of our knowledge, the first documented case of menstruation-specific exacerbation of cyclic gastrointestinal symptoms associated with SSRI treatment and proposes a pragmatic management approach. CASE SUMMARY: A 20‑year‑old woman with generalized anxiety disorder developed nausea, vomiting, diarrhea, and dizziness limited to menstrual periods after initiating escitalopram 10 mg/d; gastrointestinal symptoms persisted following a switch to paroxetine 20 mg/d. A comprehensive gynecologic work‑up (pelvic examination, hormonal assessment, and ultrasonography) was unremarkable. The Naranjo Adverse Drug Reaction Probability Scale scored 7, indicating a "probable" menstruation-specific adverse reaction. Reducing paroxetine to 10 mg/d resolved gastrointestinal symptoms, but anxiety symptoms recurred; titration to 15 mg/d achieved psychiatric remission without gastrointestinal symptom recurrence. After 6 months of stability, paroxetine was tapered off without recurrence of either gastrointestinal or anxiety symptoms. KEY FINDINGS: This case demonstrates a menstruation‑modulated SSRI adverse effect mediated by a possible interaction between serotonergic signaling and cyclical sex steroid fluctuations. IMPLICATIONS: An interdisciplinary, stepwise strategy (ruling out gynecologic disease, considering dose optimization, and monitoring menstruation‑linked symptoms) may help balance efficacy with tolerability in reproductive‑age patients. Prospective studies should evaluate SSRI-hormone interactions and menstrual-aware adverse effect monitoring.
Trisomy 18 and Ambiguous Genitalia: A Case Report.
Tosun D, Bingöl İ, Akçay N … +2 more , Sarıcalı ÇÖ, Mehmet MŞ
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41072718 · Publisher ↗
BACKGROUND: Trisomy 18 (Edwards syndrome) is a rare chromosomal disorder characterized by multiple congenital anomalies and poor survival. While the clinical spectrum is well-documented, ambiguous genitalia is not common...
BACKGROUND: Trisomy 18 (Edwards syndrome) is a rare chromosomal disorder characterized by multiple congenital anomalies and poor survival. While the clinical spectrum is well-documented, ambiguous genitalia is not commonly associated with this syndrome and is infrequently reported in the literature. CASE PRESENTATION: We report the case of a 35-day-old female infant presenting with respiratory distress and ambiguous genitalia. Physical examination revealed multiple dysmorphic features including micrognathia, dysmorphic facial features, low-set ears, agenesis of the left auricle, and limb abnormalities such as rocker-bottom feet. Ambiguous genitalia were staged as Prader and Sinnecker stage 2. Echocardiography revealed complex congenital cardiac defects, and chromosomal analysis confirmed 47,XX,+18. Despite severe anomalies, the patient remained clinically stable with supportive care. A multidisciplinary follow-up was initiated. DISCUSSION: This case highlights the importance of considering chromosomal anomalies such as Edwards syndrome in neonates with ambiguous genitalia, even in the absence of typical phenotypic findings. The presence of ambiguous genitalia should not preclude the diagnosis of Trisomy 18. Early recognition and genetic confirmation allow for appropriate counseling and management. CONCLUSION: This case contributes to the limited body of literature documenting ambiguous genitalia in Trisomy 18. Recognizing rare phenotypic presentations expands our understanding of the clinical heterogeneity of Edwards syndrome and supports early cytogenetic evaluation in neonates with multisystem anomalies.
Comparative Analysis of Dysmenorrhea Self-Care Practices Among Immigrant and Nonimmigrant Adolescents.
Sabetsarvestani R, Hosseini A, Badieisardroud S … +2 more , Köse S, Geçkil E
J Pediatr Adolesc Gynecol · 2026 Apr · PMID 41067698 · Publisher ↗
AIM: The experience of dysmenorrhea can vary significantly between immigrant and non-immigrant adolescents. This study aims to compare the dysmenorrhea self-care practices among immigrant and non-immigrant adolescents. M...
AIM: The experience of dysmenorrhea can vary significantly between immigrant and non-immigrant adolescents. This study aims to compare the dysmenorrhea self-care practices among immigrant and non-immigrant adolescents. METHOD: This study had a comparative cross-sectional design that was done in 2025. The population consisted of 209 immigrant and non-immigrant adolescent girls in 7th and 8th grade in Konya, Türkiye. Data were collected using the Adolescent Dysmenorrhea Self-Care Scale and a demographic form. Data was analyzed using independent samples t-tests, one-way ANOVA, and Pearson correlation coefficients. A p-value of less than 0.05 was considered as a statistically significant level. RESULTS: The mean age of participants was 13.71 years, and the average age at menarche was 11.84 years. Reported pain severity averaged 4.76 (maximum possible score: 10). The total dysmenorrhea self-care score averaged 87.85 (maximum possible score: 200), with significantly lower scores observed among immigrant adolescents (p < .001). Immigrants also reported a later age at menarche (p = .002) and lower scores in several dysmenorrhea self-care subdimensions. A moderate positive correlation was observed between pain severity and dysmenorrhea self-care (r = 0.394, p < .001), and a weak positive correlation was found between years lived in Türkiye and dysmenorrhea self-care (r= 0.181, p < .001). CONCLUSION: Immigrant adolescents had lower dysmenorrhea self-care scores, later menarche, and relied more on traditional methods than Turkish peers, who practiced evidence-based care. Family and culture influenced self-care, while higher pain increased engagement. Culturally sensitive school and community education is vital to enhance menstrual health literacy and equitable self-care practices.
Laparoscopic Management of Tubercular Pyosalpinx Torsion in an Adolescent Girl: A Case Report.
Gupta A, Choudhury S, Kattimani V … +1 more , Mangani D
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41067697 · Publisher ↗
Female genital tuberculosis (FGTB) is a form of extrapulmonary tuberculosis that predominantly affects women of reproductive age and is a significant cause of infertility in TB-endemic countries such as India. Tubercular...
Female genital tuberculosis (FGTB) is a form of extrapulmonary tuberculosis that predominantly affects women of reproductive age and is a significant cause of infertility in TB-endemic countries such as India. Tubercular pyosalpinx is a rare presentation of FGTB. Even more uncommon is its complication by isolated tubal torsion, which may mimic other causes of acute abdomen, making early diagnosis challenging. We report the case of a 15-year-old girl who presented with acute lower abdominal pain and vomiting. She had a 2-month history of low-grade evening fever. Clinical evaluation and ultrasound findings suggested pyosalpinx or hematosalpinx with normal ovarian morphology, raising suspicion of isolated tubal torsion. Diagnostic laparoscopy revealed a torsed, distended fallopian tube filled with purulent material and multiple peritoneal tubercles. The tube was excised using a glove-made improvised endobag to prevent intra-abdominal spillage. Histopathology confirmed tubercular salpingitis with caseous necrosis, and GeneXpert was positive for Mycobacterium tuberculosis. The patient was started on standard anti-tubercular therapy and had an uneventful recovery. This case underscores the importance of considering tuberculosis as an etiology in adolescent girls presenting with pyosalpinx, especially in TB-endemic regions. It also highlights the value of safe laparoscopic management with innovative surgical techniques in resource-limited settings. Early diagnosis, surgical intervention, and timely initiation of anti-tubercular therapy are crucial for effective management and preservation of reproductive health.
"I am so grateful you made me do this": Navigating AYA-Caregiver Discordance on Shared Decision-making about Fertility Preservation.
Feuerstein JL, Menon S, Lockart B … +2 more , Zarnegar-Lumley S, Johnson AK
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41067696 · Publisher ↗
STUDY OBJECTIVE: As survival rates improve for adolescents and young adults (AYAs) with cancer, understanding barriers to fertility preservation (FP) decision-making has become increasingly important. FP decisions involv...
STUDY OBJECTIVE: As survival rates improve for adolescents and young adults (AYAs) with cancer, understanding barriers to fertility preservation (FP) decision-making has become increasingly important. FP decisions involve both AYAs and caregivers, yet discordance in fertility goals is common and may hinder FP utilization. The factors contributing to discordance and its impact remain underexplored. This study used the Ottawa Decision Support Framework (ODSF), which identifies essential medical decision-making needs and categorizes barriers into 7 domains, to examine the experiences of discordance in FP decision-making. METHODS: Semi-structured qualitative interviews were conducted with AYA-caregiver dyads who experienced discordance during FP decision-making. Participants were aged 12-25, were ≥6 months post-cancer diagnosis, read and spoke English, and were at risk for infertility due to gonadotoxic therapy. Interviews were conducted via ZOOM between July 2024 and January 2025. Data analysis used a content analysis approach guided by existing theory and the ODSF. RESULTS: Caregivers emphasized accurate information, AYAs' maturity, and seeking external advice, whereas AYAs had greater difficulty with internal confidence and decision-making uncertainty. Caregivers often assumed directive roles due to treatment urgency and perceived AYA immaturity. AYAs, despite valuing autonomy, deferred to caregivers due to emotional distress and limited knowledge. CONCLUSION: The ODSF-guided analysis revealed several sources of discordance, though none led to FP refusal. Structured counseling mitigated decisional conflict, and all participants expressed decision satisfaction. The findings support structured counseling to align AYAs' autonomy with caregiver support. Future studies should include more diverse sociodemographic, multi-institutional samples and the perspectives of those who declined FP.
Providing Contraception to Trans Youth: A Qualitative Study Investigating the Acceptability of Subcutaneous Depot Medroxyprogesterone Acetate and Prior Experiences With Contraceptive Counseling.
Cleland NRW, Graves CE, Reade LM … +3 more , Nokoff NJ, O'Connell RP, Fang NZ
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41052747 · Publisher ↗
INTRODUCTION: The transgender and gender diverse (TGD) population continues to face unmet healthcare needs, especially when pertaining to sexual and reproductive health (SRH). When receiving care, TGD individuals may fac...
INTRODUCTION: The transgender and gender diverse (TGD) population continues to face unmet healthcare needs, especially when pertaining to sexual and reproductive health (SRH). When receiving care, TGD individuals may face discrimination or receive care that does not affirm their gender identity or is rooted in cisgender, heteronormative assumptions. This qualitative study sought to understand the experiences and perspectives of TGD youth surrounding contraceptive use and counseling, and investigate acceptability of self-administered subcutaneous depot medroxyprogesterone acetate (DMPA-SC). METHODS: We conducted semi-structured focus groups and individual interviews to understand what drove initiation and discontinuation of contraceptives, specifically DMPA-SC. We recruited 35 TGD individuals assigned female at birth, with median (IQR) age of 17.5 (2.75) years. Twenty-one participants completed focus groups and 10 completed individual interviews. Interviews were conducted virtually and analyzed using rapid thematic analysis. RESULTS: We identified 4 themes: (1) Dysmenorrhea and dysphoria associated with menses that were alleviated by DMPA; (2) DMPA seen as the best method for menstrual suppression; (3) Negative experiences with previous primary care providers (PCPs); the importance of language and a desire for individualized care regarding SRH. DISCUSSION: The SRH needs of TGD individuals differ from their cisgender counterparts. Historically, the primary endpoint for contraceptive studies focused on preventing pregnancies. Assuming this as the primary goal for TGD individuals can be harmful to the provider-patient relationship and lead to avoidance of care. When providing contraceptives at the intersection of gender identity and sexual orientation, counseling should be tailored towards an individual's unique SRH needs.
Fertility Attitudes of Adolescents and Young Adults With Turner Syndrome and Their Parents/Guardians: A Pilot Cross-Sectional Survey Study.
Dowlut-McElroy T, Hyunh VO, Roth L … +4 more , Ross M, Priebe AM, Maher JCY, Gomez-Lobo V
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41043543 · Full text
STUDY OBJECTIVE: To compare differences in attitudes between adolescents and young adults with Turner syndrome (AYA with TS) and their parents regarding future fertility and fertility preservation. DESIGN: (1) FertilityC...
STUDY OBJECTIVE: To compare differences in attitudes between adolescents and young adults with Turner syndrome (AYA with TS) and their parents regarding future fertility and fertility preservation. DESIGN: (1) FertilityConcepTS survey development with a 2-staged Delphi procedure. (2) Cross-sectional survey study. SETTING: (1) Web-based focus groups. (2) Survey dissemination during the multidisciplinary Turner syndrome clinic at a tertiary care children's hospital and via the social media platform of the Turner Syndrome Global Alliance. PARTICIPANTS: Members of the Turner syndrome community. MAIN OUTCOME MEASURES: Attitudes about (1) Interest in understanding the effects of TS on fertility and pregnancy, (2) Opinions of having children that are genetically similar, (3) Alternative methods of building a family, and (4) Medical/surgical fertility preservation procedures with unknown outcomes. RESULTS: Twenty-eight participants were included in the analysis. The median age of AYA with TS was 17.5 (IQR: 10.5) years, and of parents was 48.0 (IQR: 9.3) years. AYA with TS and their parents differed in their consideration for adoption (p = .005), use of donor egg (p < .001), use of a gestational carrier (p < .001) and raising a child as a single parent (p = .002). Although all parents agreed/strongly agreed with oocyte cryopreservation (OC) and ovarian tissue cryopreservation (OTC), 18.8% and 43.8%, of AYA with TS, respectively, disagreed/strongly disagreed with OC (p = .042) and OTC (p = .021). CONCLUSIONS: In this pilot study, AYA with TS and their parents have differing attitudes about fertility and fertility preservation. Counselling should include consideration of the needs of AYA with TS alongside parent priorities.
Adolescents, Abortion, and Reproductive Justice: An Unpostponable Debt.
Labovsky M
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41038310 · Publisher ↗
Abstract loading — click title to view on PubMed.
Implementation of No-Test Medication Abortions in Primary Care: A Roadmap from an Adolescent and Young Adult Medicine Clinic.
Raney JH, Bryson AE, Garnett CA … +3 more , Mihaly L, Buckelew SM, Raymond-Flesch M
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41038309 · Publisher ↗
STUDY OBJECTIVE: Over 2 years post-Roe, 22 states have banned or significantly limited abortion access, exacerbating existing structural barriers to abortions for adolescents and young adults (AYAs), including cost, tran...
STUDY OBJECTIVE: Over 2 years post-Roe, 22 states have banned or significantly limited abortion access, exacerbating existing structural barriers to abortions for adolescents and young adults (AYAs), including cost, transportation, parental notification requirements, and confidentiality concerns. We provide a roadmap for and demonstrate the feasibility of implementing no-test medication abortions (MABs) to expand abortion access in an adolescent-focused pediatric primary care setting. METHODS: An interdisciplinary team in an AYA-focused primary care clinic developed and implemented a no-test MAB protocol. Iterative rounds of protocol development engaged stakeholders including hospital leadership, OBGYN consultants, nurses, and program directors for residency, fellowship, and nursing trainees. Frequent interdisciplinary debriefs identified facilitators, barriers, and solutions to optimize care. RESULTS: Over 6 months, we identified clinic champions, built relationships with key stakeholders, developed clinic protocols, and disseminated MAB clinical training. In our first 6 months of implementation, we provided 4 MABs. Facilitators identified by staff include provider expertise in AYA development and patient and parent preferences for MABs in their medical home. System-level barriers (eg, timely scheduling challenges), staff factors (eg, fear of complications), and patient factors (eg, ambivalence about pregnancy) were identified. Solutions developed include establishing scheduling procedures, formalizing consultative pathways with gynecology, and integrating social work support. CONCLUSION: It is feasible for adolescent primary care practices to provide no-test MABs. Through interdisciplinary planning and iterative design, barriers from the health system, clinic staff, and patient levels can be identified and addressed, expanding equitable access to safe, AYA-focused abortion care.
Hidradenitis Suppurativa in the Pediatric and Adolescent Population.
Hickerson N, Lev-Tov H, Danker S … +1 more , Simms-Cendan J
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41038308 · Publisher ↗
Hidradenitis suppurativa (HS) is a complex disease that manifests with nodules, abscesses, and tunnels in the intertriginous regions of the body. Symptoms often begin after adrenarche and may progress to severe disease w...
Hidradenitis suppurativa (HS) is a complex disease that manifests with nodules, abscesses, and tunnels in the intertriginous regions of the body. Symptoms often begin after adrenarche and may progress to severe disease with draining tunnels and permanent scars, leading to a significant reduction in quality of life and mental health. Diagnostic delays are common, increasing the risk of disease progression. Timely diagnosis and effective management are essential to the prevention of complications in the pediatric and adolescent population. This review will cover the currently available information on pathophysiology, risk factors, presentation, diagnosis, and management of HS in this population.
Female Genital Mutilation/Cutting: A Systematic Review of Global Patterns, Sociocultural Drivers, and Health Consequences.
Xu Z, Chen X, Yu J … +1 more , Hu Y
J Pediatr Adolesc Gynecol · 2026 Apr · PMID 41038307 · Publisher ↗
STUDY OBJECTIVE: This review aims to systematically examine the global distribution, health consequences, and sociocultural drivers of female genital mutilation/cutting (FGM/C), with the aim of informing targeted elimina...
STUDY OBJECTIVE: This review aims to systematically examine the global distribution, health consequences, and sociocultural drivers of female genital mutilation/cutting (FGM/C), with the aim of informing targeted elimination strategies. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Web of Science, and Elsevier Science Direct from inception to July 2025 for studies examining FGM/C prevalence patterns, determinants, and health effects. Eligible studies were in English, addressed at least one of the review's thematic domains, and had ethics approval. Data from 329 articles were extracted and synthesized within the Socio-Ecological Model framework. RESULTS: FGM/C is mainly practiced in Africa (with national prevalence exceeding 80% in some countries) and persists within immigrant diaspora communities in Europe, North America, and Australia. While prevalence has declined in regions such as East Africa, progress has stalled in parts of West Africa and Sudan. Key drivers include limited education, deep-rooted social and religious norms, marital and economic incentives, and poverty. Legal bans exist in over 80 countries, yet enforcement gaps, cultural resistance, and medicalization hinder elimination. Across all 4 WHO-defined types, FGM/C is linked to acute and chronic physical complications (eg, hemorrhage, urogenital injury, obstetric morbidity), profound psychological sequelae (eg, PTSD, depression, sexual dysfunction), and substantial economic burden on healthcare systems. CONCLUSIONS: Eliminating FGM/C requires integrated, context-specific strategies that combine strong legislation, community engagement, educational initiatives, and expansion of survivor-centered medical and psychosocial care. Linking these actions to broader Sustainable Development Goals could accelerate progress toward ending FGM/C by 2030.
Perforated Rotated Mesenteric Cyst Presenting as Acute Abdominal Pain in a Female Pediatric Patient: A Case Report.
Dirjayanto VJ, Sugianto AI, Tamba RP
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41022299 · Publisher ↗
INTRODUCTION: Although more than half of cases are asymptomatic or mild in symptoms, mesenteric cysts can present clinically and radiologically similar to gynecologic diseases. CASE: A female child presented with worseni...
INTRODUCTION: Although more than half of cases are asymptomatic or mild in symptoms, mesenteric cysts can present clinically and radiologically similar to gynecologic diseases. CASE: A female child presented with worsening episodes of abdominal pain 1 day before admission. Abdominal x-ray suggested mechanical obstruction of the small bowel, and CT scan suggested ileal abnormality. DISCUSSION: During open surgery, we found 2 rotated chylous mesenteric cysts, accompanied by adhesions and jejunal perforation 57 cm from the ligament of Treitz. Cyst excision, adhesiolysis, ileo-ileal resection, and anastomosis were performed. CONCLUSION: Although rare and challenging to identify, mesenteric cysts should be kept in the differential diagnosis of female children presenting with abdominal pain.
Beyond PCOS: An Unusual Presentation of Type A Insulin Resistance Syndrome.
Cehic M, Milenkovic T, Todorovic S … +4 more , Mitrovic K, Zaric SP, Cvetkovic D, Vukovic R
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41022298 · Publisher ↗
BACKGROUND: Insulin resistance (IR) is commonly seen in adolescent polycystic ovary syndrome (PCOS). However, severe IR with polycystic ovaries in non-obese adolescent girls should prompt suspicion for causes other than...
BACKGROUND: Insulin resistance (IR) is commonly seen in adolescent polycystic ovary syndrome (PCOS). However, severe IR with polycystic ovaries in non-obese adolescent girls should prompt suspicion for causes other than typical PCOS. CASE: A 16-year-old normal-weight girl presented with polyuria and polydipsia, along with irregular periods, hirsutism, and acanthosis nigricans. Her clinical presentation, laboratory results and ultrasound findings suggested severe PCOS with type 2 diabetes, but the pronounced degree of IR prompted further investigations. Genetic testing identified a heterozygous deletion in the INSR gene, confirming type A insulin resistance syndrome (TAIRS). SUMMARY: This case highlights the importance of considering genetic insulin receptor abnormalities in atypical PCOS presentations, especially in non-obese adolescents with severe IR. Early recognition is crucial for appropriate management and genetic counselling.
Knowledge, Attitude, and Practice of Parents of Children Aged 9-15 Years for Human Papillomavirus Vaccine and Vaccination in Guangdong Province, China.
Wang Y, Sun N, Chen B … +3 more , Liu M, Bu R, Liu G
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41016424 · Publisher ↗
STUDY OBJECTIVE: In China, HPV vaccination coverage among young girls is relatively low, with parental knowledge, attitude, and practice (KAP) significantly influencing their daughters' vaccination decisions. To enhance...
STUDY OBJECTIVE: In China, HPV vaccination coverage among young girls is relatively low, with parental knowledge, attitude, and practice (KAP) significantly influencing their daughters' vaccination decisions. To enhance vaccination rates, Guangdong Province has implemented a free vaccination policy for the bivalent HPV vaccine for eligible girls. This study aimed to assess the KAP levels of parents in Guangdong with daughters aged 9-15 regarding HPV vaccine and HPV vaccination and identify associated factors. METHODS: A cross-sectional online survey was conducted from April 21 to 29, 2022, recruiting 4976 parents in Guangdong Province. Socio-demographic characteristics and KAP levels were analyzed using frequencies and percentages. The Chi-square test compared KAP differences across various socio-demographic groups, while multivariable logistic regression identified factors associated with KAP. RESULTS: The sample included 1837 fathers (36.98%) and 3130 mothers (63.02%). The overall correct response rate of knowledge, attitude and practice questions was 80.91%, 79.05% and 66.26% respectively. 71.41% of parents demonstrated "good" knowledge, 40.69% exhibited "positive" attitude toward vaccination, and 56.79% reported "favorable" practice. Mothers, those aged 35 or older, and individuals with university/college -level education or above were more likely to show "good" knowledge and "positive" attitude, though they also exhibited "unfavorable" practice. Additionally, parents employed in public institutions and being married tended to have better KAP. CONCLUSION: While parents in Guangdong display high knowledge and positive attitude towards HPV vaccine and HPV vaccination, inconsistencies exist between their knowledge, attitude, and practice. Future interventions should focus on well-designed educational campaigns with clear messaging and timely, transparent communication through trusted sources, in order to promote favorable practice alongside improving parental knowledge and attitude.
Improving Minimally Invasive Surgical Approaches to Large Adnexal Masses in Pediatric Gynecology: Combining Mini-Laparotomy With Single Port Laparoscopy.
Sumida MF, Winfrey OK, Hakim J … +1 more , Dietrich JE
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 41016423 · Publisher ↗
In pediatric populations large ovarian cysts are often benign, and minimally invasive approaches are preferred to minimize perioperative pain and recovery, allow for same day discharge, and improve incision cosmesis. Ova...
In pediatric populations large ovarian cysts are often benign, and minimally invasive approaches are preferred to minimize perioperative pain and recovery, allow for same day discharge, and improve incision cosmesis. Ovarian preservation is also prioritized and cystectomy is preferred over oophorectomy. While tactile sensation and dexterity are improved in mini laparotomy cases, there are limitations with visualization that are improved with laparoscopy. We describe a technique that employs both diagnostic laparoscopy and mini laparotomy using the GelPOINT Mini™ Advanced Access Platform for single site laparoscopy in pediatric patients. This case series includes cysts ranging 7-24 cm with benign preoperative risk stratification, in patients aged 3-16 years, who underwent successful same-day, ovarian-sparing surgery with the benefits of both open and laparoscopic procedures.
Enhancing Athlete Well-being with RED-S: The Potential Role of Virtual Reality for Stress Management.
Herawati AA, Ln SY, Ilfiandra … +2 more , Irawan AW, Habibi ASY
J Pediatr Adolesc Gynecol · 2025 Dec · PMID 40983308 · Publisher ↗
Abstract loading — click title to view on PubMed.
Bridging the Gap between Hypothyroidism and Precocious Puberty: A Case Report of Van Wyk Grumbach Syndrome.
Kumari O, Sharma N, Jindal M … +2 more , Dubey K, Chawla L
J Pediatr Adolesc Gynecol · 2026 Feb · PMID 40972707 · Publisher ↗
INTRODUCTION: Van Wyk Grumbach syndrome (VWGS) is a rare clinical entity that presents with the triad of precocious puberty, polycystic ovaries, and severe hypothyroidism. VWGS is an uncommon cause of precocious puberty...
INTRODUCTION: Van Wyk Grumbach syndrome (VWGS) is a rare clinical entity that presents with the triad of precocious puberty, polycystic ovaries, and severe hypothyroidism. VWGS is an uncommon cause of precocious puberty characterized by the dissociation of gonadarche and adrenarche. Unlike other etiologies of precocious puberty, VWGS is associated with absent growth acceleration and delayed bone maturation due to prolonged, untreated hypothyroidism. The diagnosis is often delayed or overlooked, as the overt or unusual pubertal manifestations may overshadow the subtle signs of hypothyroidism. Failure to identify hypothyroidism as the cause of ovarian cysts and precocious puberty may lead to catastrophic ovary resection and oophorectomy in prepubertal girls and adolescents. CASE PRESENTATION: We present a case of VWGS in a 7-year-old girl presenting with a painful abdomen with precocious puberty and menarche. A relevant review of the literature on this uncommon clinical entity is also presented. CONCLUSION: This study underscores the importance of recognizing the atypical presentation of prolonged hypothyroidism with precocious puberty in young children. This emphasizes the need for clinicians to consider the rare entity of VWGS, which could help prevent delays in appropriate management.
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