Polskie Archiwum Medycyny Wewnetrznej[JOURNAL]

A growing body of evidence indicates that coagulation factors may exhibit not only prothrombotic but also proatherogenic effects. Recent years have yielded numerous animal studies demonstrating that factor (F) XI, largel... A growing body of evidence indicates that coagulation factors may exhibit not only prothrombotic but also proatherogenic effects. Recent years have yielded numerous animal studies demonstrating that factor (F) XI, largely genetically determined, which constitutes a junction between the tissue factor-dependent coagulation and contact pathways, may contribute to the development and progression of atherosclerosis. Moreover, abundancy of FXI may propagate thrombus formation and render dense and lysis‑resistant fibrin clots, thus contributing to thromboembolic events, such as myocardial infarction (MI) and, in particular, ischemic stroke. Among FXI inhibitors, asundexian was evaluated in patients following acute MI in a phase 2 randomized PACIFIC AMI trial, without clear benefits from this intervention, while the phase 3 LIBREXIA ACS study, which aimed to assess milvexian on top of dual antiplatelet therapy in the prevention of secondary ischemic events in high‑risk MI survivors, was discontinued after interim analysis on the basis of futility. The current review summarizes the latest preclinical and clinical studies on the role of FXI in atherogenesis and its thromboembolic manifestations. Moreover, it discusses potential therapeutic options offered by FXI inhibitors.

Get PDF PubMed ↗

Recurrence of hepatocellular carcinoma after liver transplant: what is the role of direct-acting antivirals in hepatitis C virus-infected patients?

Hartleb M

Pol Arch Intern Med · 2025 Nov · PMID 41307286 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Lipoprotein(a) and body mass index in new-onset atrial fibrillation: synergistic in risk?

Mavilakandy AK, Gu T, Lip GYH

Pol Arch Intern Med · 2025 Nov · PMID 41307285 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Abstract proceedings of Young Talents in Internal Medicine World Contest 2025 (10th McMaster International Review Course in Internal Medicine, May 8-10, 2025, Kraków, Poland; hybrid course).

Pol Arch Intern Med · 2025 Nov · PMID 41262056 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Paraneoplastic palmoplantar keratoderma secondary to multiple myeloma.

Bator M, Usnarska-Zubkiewicz L, Dębski J … +3 more , Wozniak Z, Maj J, Jankowska-Konsur A

Pol Arch Intern Med · 2025 Dec · PMID 41247309 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Prevalence and characteristics of a demanding attitude among patients in Poland.

Rak J, Bonczek M, Gruszczyńska K … +1 more , Winder M

Pol Arch Intern Med · 2026 Jan · PMID 41235824 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Echocardiographic predictors of symptom relief and quality of life improvement in patients undergoing transcatheter aortic valve implantation and surgical aortic valve replacement.

Garbacz J, Lemek T, Priadka A … +3 more , Nowak S, Roczniak J, Chyrchel M

Pol Arch Intern Med · 2026 Jan · PMID 41235823 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Coexistence of Sjögren syndrome and sarcoidosis presenting as severe xerostomia.

Dudzik A, Michalak E, Płatek M … +3 more , Zielińska-Pałasz A, Ścisłowska K, Cześnikiewicz-Guzik M

Pol Arch Intern Med · 2025 Dec · PMID 41230855 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Hybrid extraction of a dislodged Abbott Aveir leadless pacemaker from the left pulmonary artery.

Kurek A, Dyrbuś M, Piegza J … +2 more , Gąsior M, Tajstra M

Pol Arch Intern Med · 2025 Dec · PMID 41230854 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Factors influencing fractional flow reserve value response after adenosine dose escalation.

Glądys K, Wojtylak M, Cionżyński W … +3 more , Roczniak J, Januszek R, Chyrchel M

Pol Arch Intern Med · 2025 Dec · PMID 41230853 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Adrenal and pancreatic echinococcosis.

Dziedzic M, Jarczyk O, Sokołowski G … +3 more , Bednarek J, Trofimiuk-Müldner M, Hubalewska-Dydejczyk A

Pol Arch Intern Med · 2025 Dec · PMID 41200950 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Novel candidate markers for early prediction of severe acute pancreatitis identified by serum proteomics.

Suski M, Dumnicka P, Sporek M … +2 more , Olszanecki R, Kuśnierz-Cabala B

Pol Arch Intern Med · 2025 Dec · PMID 41200949 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

The role of 3-dimensional echocardiography in heart thrombus assessment.

Budnik M, Wilimski R, Popko G … +1 more , Kuśmierczyk M

Pol Arch Intern Med · 2025 Dec · PMID 41182130 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Monoclonal and oligoclonal gammopathies secondary to allogeneic hematopoietic cell transplantation: a phenomenon associated with an increased survival and frequency of chronic graft-versus-host disease.

Karaszewski K, Karakulska-Prystupiuk E, Jędrzejczak WW

Pol Arch Intern Med · 2025 Dec · PMID 41181858 · Publisher ↗

INTRODUCTION: The occurrence of monoclonal gammopathies (MGs) and oligoclonal gammopathies (OGs; 2 or more monoclonal proteins) might be triggered by such factors as immune recovery following allogeneic hematopoietic cel... INTRODUCTION: The occurrence of monoclonal gammopathies (MGs) and oligoclonal gammopathies (OGs; 2 or more monoclonal proteins) might be triggered by such factors as immune recovery following allogeneic hematopoietic cell transplantation (allo‑HCT). It has been suggested that post-allo‑HCT gammopathy is associated with increased survival and frequent occurrence of chronic graft‑versus‑host disease (cGvHD). OBJECTIVES: This study aimed to verify these notions by comparing patients with and without gammopathy and, similarly, patients with MG and OG after allo‑HCT in terms of long‑term survival, the incidence and severity of cGvHD, and patient characteristics. Moreover, we aimed to explain the relation between allo‑HCT, the onset of gammopathy, and cGvHD diagnosis. PATIENTS AND METHODS: Among 241 allo‑HCT recipients evaluated from 2014 to 2024, we identified 36 cases of post-allo‑HCT gammopathy (20 MG and 16 OG). From the remaining allo‑HCT recipients, we selected a case‑by‑case matched control group of patients without gammopathy. Survival was analyzed with the Kaplan-Meier method, the Cox proportional hazards model, and the log‑rank test. RESULTS: The patients with post-allo‑HCT gammopathy had a superior 5‑year overall survival (OS) rate, as compared with the control group (79.6% vs 50.9%; P = 0.02). The frequency of cGvHD was significantly higher in the gammopathy group (odds ratio, 4.02). OG was identified mostly before cGvHD diagnosis (median [interquartile range, IQR], 6.3 [14.2-2.5] months following allo‑HCT), while MG mostly after cGvHD diagnosis (median [IQR], 4.5 [0.9-20] months following allo‑HCT). CONCLUSIONS: Post-allo‑HCT gammopathies (both MG and OG) are associated with better prognosis and increased frequency of cGvHD. There are only minor clinical differences between the patients with post-allo‑HCT MG and OG.

Get PDF PubMed ↗

Lower urinary tract symptoms in older adults as a manifestation of underlying geriatric conditions: results of a national population-based study PolSenior2.

Kujawska-Danecka H, Mossakowska M, Chudek J … +4 more , Hajduk A, Wieczorowska-Tobis K, Chmielewski M, Gryglewska B

Pol Arch Intern Med · 2025 Dec · PMID 41147427 · Publisher ↗

INTRODUCTION: Lower urinary tract symptoms (LUTS) are a common problem among older patients in primary and general care. OBJECTIVE: We aimed to estimate the prevalence of LUTS and their association with issues related to... INTRODUCTION: Lower urinary tract symptoms (LUTS) are a common problem among older patients in primary and general care. OBJECTIVE: We aimed to estimate the prevalence of LUTS and their association with issues related to health status, other geriatric problems, lifestyle factors, and social conditions in a population of Polish citizens aged over 60 years.. PATIENTS AND METHODS: The analysis was part of a national cross‑sectional study PolSenior2, conducted in the years 2018 and 2019 in a cohort of 5698 community‑dwelling older adults. Data on LUTS, health status, and socioeconomic situation were obtained based on a detailed questionnaire, International Prostate Symptom Score (IPSS), Comprehensive Geriatric Assessment, and laboratory analyses. RESULTS: The prevalence of LUTS in the Polish population aged over 60 years was estimated at 60.5%; it was significantly higher in women (67.8%; 95% CI, 64.3-71.2) than men (50.3%; 95% CI, 47.2-53.5). The most frequent symptom was nocturia (46.7%), followed by stress urinary incontinence (28.7%) and urgency (21.5%). Univariable analysis showed associations between LUTS and age, obesity, reduced functional capacity, mobility problems, a history of falls, depressive symptoms, cognitive dysfunction, multimorbidity, heart failure, diuretic use, and polypharmacy. In a multivariable regression model, age of 75 years or above, obesity, functional disability, falls, depression, cognitive impairment, multimorbidity, and polypharmacy were independently associated with the occurrence of LUTS. CONCLUSIONS: LUTS affect the majority of older adults. They are associated with numerous sociodemographic and health‑related factors, including typical geriatric problems. Therefore, it is recommended that elderly patients who present with LUTS be investigated for other common age‑related conditions and referred to a geriatrician.

Get PDF PubMed ↗

Endothelial function and cardiovascular disease in patients with rheumatoid arthritis.

Blum A

Pol Arch Intern Med · 2025 Oct · PMID 41147229 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Polskie Archiwum Medycyny Wewnetrznej[JOURNAL]

About