Bratislavske Lekarske Listy[JOURNAL]
Sun
200 papers
Fine-needle biopsy of thyroid nodules and the contribution of molecular analysis of BRAF and RAS mutations.
Kasko M, Grigerova M, Alemayehu A … +3 more , Zavodna K, Kasko V, Podoba J
Bratisl Lek Listy · 2023 · PMID 37983279 · Publisher ↗
BACKGROUND: Thyroid cancer is the most common endocrine malignancy. There is a significant overdiagnosis of thyroid carcinomas that would never clinically manifest, with consequent unnecessary surgical treatment. The fin...
BACKGROUND: Thyroid cancer is the most common endocrine malignancy. There is a significant overdiagnosis of thyroid carcinomas that would never clinically manifest, with consequent unnecessary surgical treatment. The fine-needle biopsy and subsequent cytologic examination is of crucial importance in the differential diagnosis of thyroid nodules. On the other hand, a significant portion of the results are indeterminate. OBJECTIVE: To assess the relationship of BRAF/RAS mutations in biopsy specimens to histological characteristics of thyroid nodules in individuals who undergone fine-needle biopsy and surgery. METHODS: This cross-sectional study involves 170 subjects with indeterminate cytology analyzed for BRAF/RAS mutations. RESULTS: Of all 170 patients with indeterminate cytological finding, 103 were indicated for surgery. Of these, 31 were BRAF and 25 RAS positive. Thyroid cancer was diagnosed in 59 patients, while 44 patients had non-malignant thyroid lesions. The BRAF V600E mutation was detected in 30 patients, and the RAS (K-RAS, N-RAS, and H-RAS) mutation in 13 patients with thyroid cancer. In all BRAF-positive nodules, thyroid cancer was histologically confirmed. This means a 100 % positive predictive value of BRAF testing in our study. CONCLUSION: Stratification of thyroid lesions with uncertain results of fine-needle cytology using genetic markers can help to deliver more tailored medical treatment (Tab. 6, Ref. 19).
Artificial neural networks based multimodal device for autism spectrum disorder.
Yan H
Bratisl Lek Listy · 2023 · PMID 37874810 · Publisher ↗
The neuro developmental condition known as Autism Spectrum Disorder (ASD) affects people on a lifetime basis and exhibits itself in a wide range of ways. In this research work a brand-new semi-supervised training method...
The neuro developmental condition known as Autism Spectrum Disorder (ASD) affects people on a lifetime basis and exhibits itself in a wide range of ways. In this research work a brand-new semi-supervised training method for the recognition of discrete multi-modal autism spectrum disorder is proposed. At the coarse-grained level, we consider that various methodologies are anticipated to explore equivalent information about child autism. To build DC AlexNet, this combines two small network branches and a large network (trunk network). The network trunk is programmed just to become familiar with the distinguishing characteristics shared by face images at different resolutions. It is built using recently suggested residential components. To project images to a place where their ranges are as little as possible, two branch networks are programmed to learn coupled-mappings (CMs) that are particular to a given resolution. The suggested technique is properly assessed utilizing the databases for the OMEGE and DIAEMO datasets by evaluating it to state-of-the-art techniques in terms of many parameters. Deep Coupled AlexNet is developed to obtain 98.13 % of accuracy, 95.1 % of precision, 94.3 % of recall and 95.4 of F1-score for OMEGE dataset. Moreover, 98.6 % of accuracy, 97.2 % of precision, 98.5 of recall and 97.5 % of F1-score for DIAEMO dataset (Tab. 8, Fig. 10, Ref. 16). Keywords: autism spectrum disorder, artificial neural networks, emotion recognition, interaction design, multimodal factors.
The issue of vaccine refusal: study of risky behaviour.
Stroiteleva N, Kartashova O, Osadchuk M … +2 more , Tikhonova Y, Krivetskaya M
Bratisl Lek Listy · 2023 · PMID 37874809 · Publisher ↗
BACKGROUND: The aim of this study is to identify the influence of factors that determine the refusal of influenza vaccine among three subjects groups. METHODS: A survey was conducted amongst three high‑risk groups in yea...
BACKGROUND: The aim of this study is to identify the influence of factors that determine the refusal of influenza vaccine among three subjects groups. METHODS: A survey was conducted amongst three high‑risk groups in years 2018-2019 (Moscow, Russia). The survey involved 1,620 parents and pregnant women (group 1), 324 doctors (group 2) and 433 students (group 3). The analysis revealed a poor vaccine uptake among respondents of all three groups. RESULTS: According to the survey results, only 22.2 % of children and 13.8 % of adults were vaccinated against influenza. The group 2 showed higher rates for vaccinated adults and children, namely 36.7 % and 58.7 % , respectively. The lowest adherence to annual vaccinations was recorded in group 3 (only 17.3 %). There is also a negative correlation between adherence to vaccination and smoking -0.66), unhealthy diet -0.73), poor oral hygiene -0.61) as well as insufficient awareness of the need of influenza vaccine -0.81). CONCLUSION: The general lack of vaccination awareness has a fundamental role in forming a negative attitude toward influenza vaccine. It is necessary to conduct research to promote vaccination against influenza to improve vaccine uptake among high‑risk groups, particularly in students (Tab. 1, Fig. 1, Ref. 32).
Anticoagulation therapy in hospitalized patients with COVID-19: a meta-analysis of randomized clinical trials.
Matos B, Paludeto GT, Neto AC … +1 more , Bignardi PR
Bratisl Lek Listy · 2023 · PMID 37874808 · Publisher ↗
Thromboembolic events are common in hospitalized patients with COVID-19, suggesting that SARS-CoV-2 infection may be related to a prothrombotic state. Several clinical trials evaluating different anticoagulation strategi...
Thromboembolic events are common in hospitalized patients with COVID-19, suggesting that SARS-CoV-2 infection may be related to a prothrombotic state. Several clinical trials evaluating different anticoagulation strategies were developed. Thus, we proposed conducting a meta-analysis of randomized clinical trials that evaluated the efficacy and safety of therapeutic anticoagulation with heparins in hospitalized patients with COVID-19. We searched PubMed, Cochrane, and Epistemonikos for studies published until December 22, 2022. Nine studies compared prophylactic/intermediate anticoagulation versus therapeutic anticoagulation with heparins were included. Four efficacy and one safety endpoints were analyzed: all-cause mortality, thromboembolic events, pulmonary embolism, need of intensive care unit or non-invasive ventilation, and major bleeding. Compared with prophylactic/intermediate anticoagulation, therapeutic anticoagulation with heparins was not associated with a reduction in all-cause mortality and need of intensive care unit or non-invasive ventilation in hospitalized patients with COVID-19, but showed a reduction in the number of thromboembolic events (RR 0.54, 95% CI 0.41-0.71, I2 = 0 %) and pulmonary embolisms (RR 0.37, 95% CI 0.24-0.57, I2 = 0 %), besides an increase in major bleeding (RR 1.67, 95% CI 1.05-2.64, I2 = 0 %). This meta-analysis did not show a reduction in all-cause mortality in hospitalized patients with COVID-19 who received anticoagulation with heparin at a therapeutic dose compared to those who received a prophylactic/intermediate dose, as well as no significant differences were found in the need of intensive care unit admission or use of non-invasive ventilation. There was, however, a reduction in thromboembolic events, pulmonary embolism, and increased bleeding (Tab. 1, Fig. 5, Ref. 31). Keywords: COVID-19, anticoagulation, heparins, meta-analysis.
The effect of protocatechuic acid on ovarian histopathology and reserve in rat ovarian torsion model.
Erimsah S, Cetinkaya A
Bratisl Lek Listy · 2023 · PMID 37874807 · Publisher ↗
OBJECTIVES: The aim of the study is to investigate the effects of Protocatechuic Acid (PCA), which is an antioxidant, anti-inflammatory and anti-apoptotic agent, on ovarian tissue and ovarian reserve against ischemia-rep...
OBJECTIVES: The aim of the study is to investigate the effects of Protocatechuic Acid (PCA), which is an antioxidant, anti-inflammatory and anti-apoptotic agent, on ovarian tissue and ovarian reserve against ischemia-reperfusion (IR) injury in a rat ovarian torsion model. BACKGROUND: Reactive oxygen radicals cause histopathological changes in the ovarian tissue during the reperfusion phase. PCA may have protective effects on ovarian tissue and reserve due to its antioxidant and antiapoptotic properties. METHODS: A total of 24 Wistar adult female rats were divided into 3 groups as the control (sham operation, n = 8), IR (Ischemia-Reperfusion, n = 8), and IR+PCA (Ischemia-Reperfusion + 80 mg/kg protocatechuic acid, n = 8). The IR and IR + PCA groups underwent 3 hours of ischemia followed by 3 hours of ovarian reperfusion. Protocatechuic acid (80 mg/kg) was administered to the IR+PCA group 30 minutes before reperfusion. After reperfusion, the ovaries were removed for histopathological and biochemical examination. RESULTS: Histopathological score and TUNEL+ cell count were significantly lower and AMH expression level was significantly higher in the IR+PCA group when compared to the IR group (p <0.05). However, in the comparison of the follicle counts, there was no statistically significant difference between all groups. Due to the increase in antioxidant activity, the MDA levels were found to be significantly lower in the IR+PCA group compared to the IR group (p < 0.05). CONCLUSION: Protocatechuic acid may be an effective antioxidant in protecting ovarian tissue and follicle reserve against IR injury of the ovary (Tab. 1, Fig. 4, Ref. 36).
Joinpoint analysis of colorectal cancer trend in the Slovakia.
Pham PT, Pekarcikova J, Edelstein R … +1 more , Majdan M
Bratisl Lek Listy · 2023 · PMID 37874806 · Publisher ↗
OBJECTIVES: The aim of this study is to describe the colorectal cancer trend in the Slovakia between 2002 and 2019. BACKGROUND: In 2020, the Slovakia ranked second among the 10 countries with the highest incidence of col...
OBJECTIVES: The aim of this study is to describe the colorectal cancer trend in the Slovakia between 2002 and 2019. BACKGROUND: In 2020, the Slovakia ranked second among the 10 countries with the highest incidence of colorectal cancer and the highest number of deaths from colorectal cancer (hereafter also referred to as CRC). METHODS: To describe the situation of CRC, indicators of incidence and mortality rates stratified by age and sex for the available time period were chosen. A joinpoint regression software was used to identify changes in the trend of development. RESULTS: During the 18-year follow-up period (2002-2019), the overall trend in colorectal cancer incidence continued to increase with an overall mean annual change of 1.3 %. The incidence of CRC tended to increase from 50 years of age and increased with age. The most pronounced increasing trend was observed in the age group of 75 years and older (AAPC in men 1.9 %, IS +1.4; +2.5 and in women 2.0 %, IS +1.6; +2.4). CRC mortality remained relatively stable for the entire 18-year period. A decreasing trend in mortality was observed in the 25-49 age group with an overall annual percentage decrease of 0.9 % (IS -1.5; -0.3), while an increasing trend was observed in the 75+ age group with an overall annual percentage increase of 1.0 % (IS +0.8; +1.3). The incidence and mortality rates in men were higher than in women. CONCLUSION: The situation of colorectal cancer trend in the Slovakia has improved compared to the previous period (1971-2001) (Tab. 4, Fig. 4, Ref. 34).
The importance of sentinel lymph node diagnostic biopsy from the lateral neck compartment in the surgical treatment of papillary thyroid cance.
Arciniegas LM, Reken V, Nemergut S … +3 more , Sabol M, Durdik S, Kralik R
Bratisl Lek Listy · 2023 · PMID 37874805 · Publisher ↗
OBJECTIVES: The aim of our study is to determine whether mapping the lymphatic drainage and diagnostic excision of lymph nodes from lateral neck compartment is able to detect ultrasound unknown metastases in this compart...
OBJECTIVES: The aim of our study is to determine whether mapping the lymphatic drainage and diagnostic excision of lymph nodes from lateral neck compartment is able to detect ultrasound unknown metastases in this compartment early and thus favorably affect the prognosis of patients with papillary thyroid cancer (PTC). BACKGROUND: Lymph node involvement in the lateral neck compartment is seen in 30-60 % of patients with PTC at the time of diagnosis and affects the prognosis of patients in terms of disease recurrence. METHODS: From June 2012 to December 2016, 154 patients with no evidence of lateral nodal involvement on imaging studies were treated with total thyroidectomy and central comparment neck dissection. A volume of 0.2 ml of Patent Blue dye was applied in the upper half of the thyroid gland with subsequent exposure of lymphatic drainage in the lateral compartment and 2-3 sentinel lymph nodes (SLN) were removed for frozen section (Group 1). In case of metastatic involvement, a lateral comparment neck dissection was performed. The reference groups were composed of a set of patients without detected lymphatic drainage (Group 2) and a set of patients who underwent lateral compartment neck dissection for preoperatively detected metastases in the lymph nodes (Group 3). The biochemical, structural and overall persistence of the disease at the time of administration of adjuvant radioiodine ablation was evaluated. RESULTS: The SLN identification rate was 95.45 %. In Group 1, a total of 32 patients had a positive SLN. Out of these, 24 patients had positive SLNs based on the analysis of frozen section, while in 8 patients, the positive diagnosis was confirmed through definitive histology. The comparison of data from the entire follow-up period in all three groups of patients revealed statistically significant differences in persistence of disease, namely in favor of Group 1. The percentage of reoperations for persistence and recurrence of disease was significantly lowest in Group 1 (2.04 %) compared to Groups 2 and 3 (6.94 % and 45.45 % respectively). CONCLUSION: The method is safe and sensitive for detecting unknown lymph node metastases in the lateral neck compartment, and may facilitate a decision to perform accurate surgical treatment of patients with PTC (Tab. 4, Fig. 2, Ref. 38).
Investigating the effectiveness of self-management program based on 5A model on fatigue and dyspnea in patients with heart failure.
Hajmohamadi M, Imani-Goghary Z, Jahani Y … +1 more , Sabzevari S
Bratisl Lek Listy · 2023 · PMID 37874804 · Publisher ↗
BACKGROUND: Some symptoms such as fatigue and dyspnea decrease the quality of life in patients with heart failure. The effectiveness of self-management programs on management of chronic conditions was discussed. So, this...
BACKGROUND: Some symptoms such as fatigue and dyspnea decrease the quality of life in patients with heart failure. The effectiveness of self-management programs on management of chronic conditions was discussed. So, this study aimed to investigate the effectiveness of self-management program based on 5A model on fatigue and dyspnea in patients with heart failure. METHODS: In this clinical trial study, 60 patients with heart failure were included. The intervention group underwent self-management program based on 5A model and the control group received routine care. All the enrolled patients were evaluated once at baseline and once after 3 months using fatigue severity and Borg dyspnea scales. The obtained data were analyzed using SPSS software version 16 by descriptive statistics and independent t-test, covariance test, and paired sample t- test. The significance level was set at 0.05. RESULTS: There was no significant difference in the mean scores of fatigue and dyspnea at the beginning of the study between control and intervention groups (p > 0.05), but 3 months after intervention a significant difference was found in mean scores of fatigue and dyspnea between two groups, (p < 0.05). The difference between pre- and post-intervention scores in terms of the dyspnea and fatigue variables was significant based on the result of paired sample t-test (p < 0.05). CONCLUSION: According to the results of this study, self-management program based on 5A Model can be used to reduce the severity of fatigue and dyspnea as well as improve the quality of life in patients with heart failure (Tab. 4, Fig. 1, Ref. 33).
Investigation of the miR-637 and miR-523-5p as candidate biomarkers in breast cancer.
Coskunpinar E, Tiryakioglu DZ, Abaci N … +2 more , Tukenmez M, Pence S
Bratisl Lek Listy · 2023 · PMID 37874803 · Publisher ↗
OBJECTIVES: The distinction of benign lesions from malign tumors is crucial for the diagnosis and treatment of breast cancers. BACKGROUND: The aim of this study was to investigate the use of miRNAs as plasma biomarkers f...
OBJECTIVES: The distinction of benign lesions from malign tumors is crucial for the diagnosis and treatment of breast cancers. BACKGROUND: The aim of this study was to investigate the use of miRNAs as plasma biomarkers for the discrimination of malign and benign breast tumors. METHODS: Whole blood samples obtained from 40 individuals in 3 groups designated as invasive ductal carcinoma group, fibroadenoma group and healthy controls were included in this study. The expression levels of 372 miRNAs were determined using RT-PCR. Results: The comparison of fibroadenoma group with healthy controls revealed an upregulation of thirty miRNAs and downregulation of twenty-nine miRNAs. The comparison of invasive ductal carcinoma (IDC) group with controls has shown that eight miRNAs were upregulated while eleven miRNAs were downregulated. When comparing IDC and fibroadenoma groups, 15 miRNAs were found to be upregulated, while 10 miRNAs were downregulated. Further analysis of these miRNAs aimed to determine their power in distinguishing IDCs from fibroadenomas. Among the miRNAs analyzed, seven miRNAs have shown sufficient discriminative power, of which three miRNAs, namely miR-637, miR-523-5p and miR-490-3p, have shown a significantly high discriminative power. CONCLUSIONS: Circulating miR-637 and miR-523-5p combination maybe used to discriminate between invasive ductal carcinomas and fibroadenomas. (Tab. 9, Fig. 4, Ref. 30).
Branchiogenic cyst ‒ a rare finding in vascular surgery.
Zavacka M, Pobehova J, Zavacky P
Bratisl Lek Listy · 2023 · PMID 37874802 · Publisher ↗
Branchiogenic cysts are benign lesions caused by anomalous development of the branchial cleft. They are typically detected in individuals aged between their twenties and forties. Ultrasonography is the first-line imaging...
Branchiogenic cysts are benign lesions caused by anomalous development of the branchial cleft. They are typically detected in individuals aged between their twenties and forties. Ultrasonography is the first-line imaging method of choice. Surgical excision is the sole treatment modality (Tab. 1, Fig. 6, Ref. 25). Keywords: branchiogenic cyst, extirpation, ultrasonography, computed tomography.
Acute pancreatitis - predicting the severity of the disease.
Csomor J, Hribek P, Kupsa T … +2 more , Bradac O, Urbanek P
Bratisl Lek Listy · 2023 · PMID 37874801 · Publisher ↗
RATIONALE: Acute pancreatitis (AP) is a serious acute abdominal disease. AP is often referred to as an unpredictable illness, which can take a mild to severe (fatal) course. AIMS OF THE STUDY: 1) To identify clinical par...
RATIONALE: Acute pancreatitis (AP) is a serious acute abdominal disease. AP is often referred to as an unpredictable illness, which can take a mild to severe (fatal) course. AIMS OF THE STUDY: 1) To identify clinical parameters that are significantly related to the clinical course of acute pancreatitis. 2) To compile a scoring system enabling the severity of AP to be predicted when the patient is first admitted to hospital. METHODS: Analysis of available publications and clinical guidance, and retrospective analysis of data on patients hospitalised with AP at our clinic enable us to identify clinical details and laboratory results recorded at the time of patients' admission to hospital that are related to the subsequent severity of the disease. For the purposes of statistical analysis, the sample of patients was divided into two groups: group A (mild AP, without local or organ complications), group B (moderately severe and severe AP with local and/or organ complications). PATIENT GROUPS AND RESULTS: In total, between 01.01.2013 and 30.06.2022, 312 patients with acute pancreatitis were allocated to the retrospective-prospective study sample. 74 % (231/312) of these patients were allocated to group A and 26 % (81/312) were allocated to group B. Univariate analysis of the data collected on the patient sample identified 5 parameters that are statistically significantly associated with the severity of the clinical course of the disease. Presence of SIRS on admission (A vs B, Odds ratio 10.787, 95% CI 5.09-22.85, p < 0.0001), diabetes mellitus type 2 in case history (A vs B, Odds ratio 7.703, 95% CI 3.04-19.51, p 2 mmol/l (A vs B, Odds ratio 3.293, 95% CI 1.59-6.82, p = 0.0013).In order to develop a scoring system, each of these parameters was allocated a points value based on its Odds ratio (OR): presence of SIRS 3 points, hypocalcaemia 3 points, diabetes mellitus type 2 in case history 2 points, urea concentration > 8 mmol/l 1 point and lactate concentration > 2 mmol/l 1 point. The authors refer to their scoring system as The Acute Pancreatitis Admission Score (APAS). The accuracy of APAS was modelled for various cut off values. Across the whole sample, we ascertained that an APAS ≥ 4 points predicts moderately severe or severe AP with a sensitivity of 81 % (95% CI: 71 - 89 %) and specificity of 87 % (95 CI: 81 - 91 %). The positive predictive value (PPV) of APAS ≥ 4 is 0.68, while its negative predictive value (NPV) is 0.93 and accuracy 0.85 (95% CI 0.81 - 0.89). CONCLUSION: In this study we identify significant simple clinical and laboratory parameters that are commonly tested as part of an initial examination when admitting a patient with AP to hospital. Having identified these parameters we are able to establish a simple scoring system that is able to predict the severity of the course of AP at the moment of hospitalisation (Tab. 5, Fig. 2, Ref. 27).
The influence of gender differences on the illness perception and women's point of view on COPD.
Jankovic J, Djurdjevic N, Jandric A … +4 more , Karic U, Milivojevic I, Ratkovic A, Buha I
Bratisl Lek Listy · 2023 · PMID 37874800 · Publisher ↗
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is an irreversible disease and has influence on patients' quality of life. The aim is to investigate the influence of gender on the illness perception in COPD pati...
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is an irreversible disease and has influence on patients' quality of life. The aim is to investigate the influence of gender on the illness perception in COPD patients. MATERIALS AND METHODS: This prospective study enrolled 151 COPD patients. For the evaluation of illness perception, we used Brief Illness Perception Questionnaire (BIPQ). RESULTS: Average FEV1 values were significantly different (p = 0.007) in favor of woman compared to men. There was a higher proportion of GOLD stage 3 and less stage 4 in women. We found a significant difference in total BIPQ scores between female and male patients (p = 0.008). Women gave a significantly higher score on question 6 and 8 (p = 0.003). We found a significant difference in total BIPQ scores between female and male patients. Women perceive COPD as a significantly more threatening disease and accept chronic course and long-term treatment. CONCLUSION: COPD is no longer a disease that predominantly affects men. BIPQ is a convenient tool for fast assessment of illness perception for COPD. Patients' perceptions of COPD is in correlation with gender and GOLD stadium. The results of this study have potential benefits in terms of health promotion and improvement of the quality of life and outcome (Fig. 4, Ref. 21).
The contemporary ways of introduction ECG technology: ML, telemetry and bioauthentification.
Shcheglov B, Konoreva N, Koval V … +2 more , Andryukov B, Shcheglova S
Bratisl Lek Listy · 2023 · PMID 37789797 · Publisher ↗
It has been exactly 180 years since the pioneering work of Dr. Carlo Matteucci, professor of physics at the University of Pisa (1842), laid the basis of the method for the registration of biopotentials generated by muscl...
It has been exactly 180 years since the pioneering work of Dr. Carlo Matteucci, professor of physics at the University of Pisa (1842), laid the basis of the method for the registration of biopotentials generated by muscles. In particular, these studies have found practical application in the principal non-invasive method of functional diagnosis of the cardiac muscle - electrocardiography (ECG). Almost a century has passed since this method became recognized and widely used in the clinic. However, to date, it has not only retained its importance in practical medicine but also remains a valuable diagnostic tool. This method allows understanding and effectively prevents errors in the present and future repetition. There are observed favorable trends of ECG-based diagnostics systems implementation and improvement in functional assessment of myocardium electrophysiological characteristics, which reflect cardiovascular pathological vital markers. The essential aim of this article is to demonstrate modern approaches of implementing ECG technology to various fields of medicine and health informatics. This research demonstrated a large number of modern innovations devoted to the automation and modification of implementation of this electrophysiological method and the possible ways to implement it in matters of home and individual monitoring of patients. Furthermore, the review examines the socio-economic issues of deploying and administering tele-ECG technologies to follow up on the global principles of digitization of healthcare and on-site diagnostics by emergency medical services (Tab. 2, Fig. 4, Ref. 87). Keywords: electrocardiography, tele-ECG, user bioauthentification.
The frequency of, and predisposing risk factors for, ciprofloxacin-induced neuro-psychiatric adverse drug reactions.
Hartinger JM, Dvorackova E, Myslivecek M … +7 more , Hruskova Z, Satny M, Zlatohlavek L, Krizova J, Sima M, Tesar V, Slanar O
Bratisl Lek Listy · 2023 · PMID 37789796 · Publisher ↗
OBJECTIVES: Ciprofloxacin induces rare neuro-psychiatric adverse drug reactions (ADRs) that are, as yet, not possible to predict due to unknown predisposition factors. BACKGROUND: The aim of the analysis was to assess th...
OBJECTIVES: Ciprofloxacin induces rare neuro-psychiatric adverse drug reactions (ADRs) that are, as yet, not possible to predict due to unknown predisposition factors. BACKGROUND: The aim of the analysis was to assess the frequency of neuro-psychiatric ADRs and to identify potential risk factors that predisposed patients to ciprofloxacin neurotoxicity. METHODS: This observational retrospective study involved the evaluation of the medical records of patients in the Nephrology department and 3rd Internal Clinic of the General University Hospital in Prague. RESULTS: The overall incidence of neurological ADRs was 3.6 %. No neurological ADRs developed in patients aged less than 70 years. The covariates that were significantly more prevalent in the patients who developed neuropsychiatric ADRs were as follows: higher age, a history of neuropsychiatric disorders and the use of anticonvulsants. The administration of drugs from other ATC groups, gender, weight, body mass index, body surface area, renal functions, level of C-reactive protein at the beginning of treatment and the total daily dose/kg did not differ significantly between the two groups. CONCLUSION: Ciprofloxacin neuropsychiatric ADRs are more frequent in older patients with a history of neurologic or psychiatric disorders. No other tested covariates were proven to predispose patients to neuropsychiatric ADRs during treatment with ciprofloxacin (Tab. 2, Ref. 20).
Basal cell carcinoma cytology revisited - a modern perspective on an old technique.
Durikova P
Bratisl Lek Listy · 2023 · PMID 37789795 · Publisher ↗
Basal cell carcinoma is the most frequently occurring cancer in humans. In light of its vast prevalence, this disease causes a substantial burden on the quality of life of patients. Histopathologic examination is current...
Basal cell carcinoma is the most frequently occurring cancer in humans. In light of its vast prevalence, this disease causes a substantial burden on the quality of life of patients. Histopathologic examination is currently the gold standard for diagnostic confirmation and a requisite for therapeutic planning. Cytology possesses several advantages compared to biopsy. This is namely due to its minimal invasiveness, absence of scarring, improved aesthetic outcome, cost-effectiveness, and procedural simplicity. This review focused on contemporary evidence on basal cell carcinoma cytology to provide a comprehensive description of the technique with practical insights for specific clinical scenarios. This review also aimed to delineate and discuss evidence gaps and potential novel applications of this technique in the context of recent advances in cytopathology, dermatosurgery, molecular targeted therapy, and precision medicine (Tab. 2, Ref. 43). Keywords: basal cell carcinoma, cytology, Papanicolaou test, May-Grunwald Giemsa.
Comparison of effects of quercetin and ascorbic acid on inflammatory cytokines and antioxidant biomarkers in infant rats using an experimental sepsis model.
Bozkurt EU, Ozel A, Erol M … +4 more , Tenekecigil A, Gayret OB, Buke O, Tosun V
Bratisl Lek Listy · 2023 · PMID 37789794 · Publisher ↗
OBJECTIVE: There is ongoing research on treatments that promote antioxidant and anti-inflammatory mechanisms, which will reduce mortality in sepsis. In this study, we compared the anti-inflammatory and antioxidant activi...
OBJECTIVE: There is ongoing research on treatments that promote antioxidant and anti-inflammatory mechanisms, which will reduce mortality in sepsis. In this study, we compared the anti-inflammatory and antioxidant activities of quercetin and ascorbic acid using a sepsis model induced in infant rats. METHODS: A total of 28 infant rats 21-days-old that had just completed the lactation period were divided into four groups: control, sepsis, sepsis + quercetin, and sepsis + ascorbic acid. The sepsis model was created with an intraperitoneal injection of bacterial lipopolysaccharide. After 24 hours, blood samples were collected for analysis of serum levels of inflammatory cytokines (IL-1β, IL-6, TNF-α, and CRP) and antioxidants (CAT, GPx, SOD, and GST). RESULTS: The superoxide dismutase levels were significantly higher in the sepsis + ascorbic acid group compared to the sepsis and sepsis + quercetin groups. The levels of the most active cytokines in sepsis were significantly lower in the serum samples of the septic subjects who received quercetin and ascorbic acid. CONCLUSION: The antioxidant activity, which is impaired in sepsis, was increased by both molecules. We observed that these two molecules, which are free of side effects, have a positive influence on the progression of sepsis to severe and fatal sepsis in childhood (Tab. 2, Ref. 38).
Radar reflector guidance system in breast surgery: A single-institution feasibility study.
Pohlodek K, Feriancova M, Meciarova I
Bratisl Lek Listy · 2023 · PMID 37789793 · Publisher ↗
Mammography breast cancer screening programs and continuing improvements in early diagnosis of the disease have led to more frequent detection of nonpalpable breast lesions. The commonly used technique in guiding the sur...
Mammography breast cancer screening programs and continuing improvements in early diagnosis of the disease have led to more frequent detection of nonpalpable breast lesions. The commonly used technique in guiding the surgical removal of these lesions is hook wire-guided localization (WGL). However, the WGL procedure has been criticized for the last years. Key disadvantages of WGL are possible wire transection, wire migration before or during surgery, patient discomfort and pneumothorax. Over the last decade, alternatives to wire localization have emerged. In this study the authors present their initial experience with a wireless, nonradioactive, wave reflection implant system that enables surgeons to safely and accurately remove breast lesions (Tab. 2, Fig. 4, Ref. 20). Keywords: breast cancer, breast surgery, nonpalpable lesions, preoperative localization.
Advantages of virtual planning in reconstructive surgery of bone defects in the maxillofacial region.
Simko K, Czako L, Sovis M … +4 more , Vidova I, Sufliarsky B, Odnoga P, Galis B
Bratisl Lek Listy · 2023 · PMID 37789792 · Publisher ↗
OBJECTIVES: Our analysis focuses on the advantages of virtual surgical planning (VSP) compared to a conventional treatment method as well as on a wider range of parameters influencing the surgical procedure, postoperativ...
OBJECTIVES: Our analysis focuses on the advantages of virtual surgical planning (VSP) compared to a conventional treatment method as well as on a wider range of parameters influencing the surgical procedure, postoperative care, morbidity and lastly, the survival rate of these patients. BACKGROUND: Patients with extensive bone defects of different etiologies of the upper or lower jaw who underwent complex reconstructive surgery with a free fibula flap (FFF). METHODS: We retrospectively analyzed data from a total of 34 patients (12 female and 22 male) whose defects were reconstructed with an osteomyocutaneus FFF. The data were collected over a period of 6 years from 2017 to 2023. We divided the patients into two groups, namely those who underwent conventional surgical treatment (5 patients) and those who underwent computer‑planned surgical treatment (29 patients). RESULTS: The duration of surgery showed a significant difference between the VSP group and the conventional group (t(32) = 3.316; p < 0.01), with the VSP group having a significantly shorter surgery time (M= 8:10; SD = 1:18) compared to the conventional group (M = 10:52; SD = 2:41). The independent t-test revealed significant differences between the VSP group (M = 45.967; SD 14.548) and conventional group (M = 17.61; SD = 24.996) for the dose of unfractionated heparin per kilogram administrated immediately after vascular micro anastomosis (t(32) = -3.609; p < 0.001). CONCLUSION: Among all the risk factors, administering a higher unfractionated dosage of heparin administered immediately after completing the anastomosis was identified as a significant predictor of postoperative complications. Using VSP in cases of advanced stage head and neck malignancy for salvage surgery is highly recommended. Shorter duration of these comprehensive surgeries in the VSP group leads to a significantly favorable outcome (Tab. 2, Fig. 2, Ref. 19). Text in PDF www.elis.sk Keywords: virtual planning, microvascular flap, maxillofacial, free fibula flap, reconstructive surgery.
Very early risk modeling in patients with chest pain based on the pattern on admission ECG.
Muzyk P, Morawiec B, Szydlowski R … +4 more , Pabis P, Siwek M, Kocjan M, Kawecki D
Bratisl Lek Listy · 2023 · PMID 37789791 · Publisher ↗
OBJECTIVES: The aim was to investigate the prognostic accuracy of admission ECG and its usefulness in determining the population at the highest risk of worse outcomes. BACKGROUND: Fast and accurate assessment of chest pa...
OBJECTIVES: The aim was to investigate the prognostic accuracy of admission ECG and its usefulness in determining the population at the highest risk of worse outcomes. BACKGROUND: Fast and accurate assessment of chest pain patients remains a challenge for clinicians. Electrocardiogram (ECG) is performed in each case of suspicion of the cardiac origin of chest pain. METHODS: Consecutive adult chest pain patients with suspicion of acute myocardial infarction (AMI) were enrolled in the study. The prognostic value of admission ECG changes alone and in combination with other clinical variables (cardiac troponin, diagnosis of AMI) were analyzed for the incidence of major adverse cardiac events (MACE) in a one‑year observation. RESULTS: The ischemic pattern on admission ECG was a single risk factor of MACE (HR 2.996 95% CI 1.31-6.86, p = 0.009), contrary to the single admission high-sensitivity cardiac troponin T assay (hs-cTnT) (HR 1.79 95% CI 0.695-4.61). The highest risk of MACE was identified in case of the presence of both ischemic-ECG and positive hs-cTnT (HR 3.19 95% CI 1.496-6.81, p = 0.003). CONCLUSIONS: The presence of ischemic changes in ECG in chest pain population with AMI suspicion increases the risk of MACE. The group at highest risk of MACE can by identified by the additional stratification with the admission single hs-TnT measurement (Tab. 2, Fig. 4, Ref. 40). Text in PDF www.elis.sk Keywords: acute coronary syndromes, cardiac troponin, electrocardiogram, emergency department, chest pain.
A single-centre report of acute pyelonephritis in a patient after kidney transplantation - analyses of risk factors.
Gala I, Baltesova T, Hulik S … +4 more , Kalanin R, Adandedjan D, Katuchova J, Bena L
Bratisl Lek Listy · 2023 · PMID 37789790 · Publisher ↗
BACKGROUND: Urinary tract infections (UTI) are the most common infectious complications after kidney transplantation (KTx) with highest incidence in the first three months of transplantation. UTI in transplant recipients...
BACKGROUND: Urinary tract infections (UTI) are the most common infectious complications after kidney transplantation (KTx) with highest incidence in the first three months of transplantation. UTI in transplant recipients increase morbidity and mortality, risk of graft failure and incidence of acute rejection episodes. According to published data, urinary tract infections significantly affect graft survival. The aim of our study was to identify possible risk factors for the development of UTI. MATERIAL AND METHODS: We retrospectively analyzed a cohort of patients who received kidney transplantation between January 2014 and December 2016 in the Transplant Center of Louis Pasteur University Hospital in Košice. One hundred and fifty-three patients after kidney transplantation were included in the study. RESULTS: A total of 47 Caucasian patients (30%) developed UTI, namely - acute pyelonephritis after KTx. We identified independent risk factors associated with UTI such as female gender OR (7.98, 95% CI 2.88-22.12, p < 0.001), diabetes mellitus (OR 5.26, 95% CI 2.01-13.74, p = 0.001; 95% CI 4.57-53.82, p < 0.001) urologic complication (OR 15.68, 95% CI 4.57-53.82; p < 0.001) and acute rejection episode (OR 3.15, 95% CI 1.13-8.76, p = 0.027). The most common microbiological agent was Escherichia coli. CONCLUSION: We identified the aforementioned risk factors of urinary tract infections in the files of our patients. Statistically, the most significant risk factors are the female gender, and presence of urological complications. The urological complications and BMI of the patients are considered modifiable factors. Based on our analysis, we confirmed a significantly higher number of ACR patients who overcame infection which is in accordance with the published data on association of UTI with the development of acute cellular rejection (ACR) (Tab. 2, Fig. 1, Ref. 15).
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe