Devaux CA, Mediannikov O, Davoust B
… +2 more, Parola P, Raoult D
Med Sante Trop
· 2019 Nov · PMID 31884984
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Since the AIDS pandemic and the demonstration that it originated in the accidental transmission of simian retroviruses to humans, no one can ignore the role of nonhuman primates in carrying pathogens that can cross the s...Since the AIDS pandemic and the demonstration that it originated in the accidental transmission of simian retroviruses to humans, no one can ignore the role of nonhuman primates in carrying pathogens that can cross the species barrier to infect humans. In recent decades, viruses as deadly as those for rabies, Herpes B, Marburg hemorrhagic fever, and Ebola have been transferred from monkeys to humans. Because great apes are genetically our closest relatives, the pathogens that colonize these mammals are probably best adapted to pass into humans should accidental exposure occur. This article attempts to evaluate the risks of infection when apes and humans share the same ecosystem.
Traoré SI, Bilen M, Cadoret F
… +4 more, Khelaifia S, Million M, Raoult D, Lagier JC
Med Sante Trop
· 2019 Nov · PMID 31884983
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The interest in studying gut microbiota has been rekindled with the advent of molecular techniques, in particular, metagenomics. Culturomics (high throughput microbial culture with identification of the colonies by Maldi...The interest in studying gut microbiota has been rekindled with the advent of molecular techniques, in particular, metagenomics. Culturomics (high throughput microbial culture with identification of the colonies by Maldi-TOF) has demonstrated its complementarity with metagenomics for comprehensive study of the microbiota. The main metagenomic studies have revealed an increase in biodiversity, with in particular an increase of Spirochaetes and Prevotella in subjects of African origin compared with Western subjects. Studies on malnutrition have shown a reduction of all bacteria and in particular of anaerobic bacteria and methanogenic archaea. Of the 1,162 bacteria isolated by culturomics studies, 476 were isolated only from non-African samples, 445 were isolated in African and non-African groups, and 241 bacteria were isolated from samples of African origin including 68 new species. Further studies of African microbiota by culturomics and metagenomics will make it possible to assess whether some bacteria have particular specificities and if these might play a role in certain pathologies such as malnutrition.
Ayouba A, Mbala-Kingebeni P, Keita AK
… +7 more, Vidal N, Lacroix A, Touré A, Muyembe-Tamfum JJ, Delaporte E, Peeters M, Ahuka-Mundeke S
Med Sante Trop
· 2019 Nov · PMID 31884982
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Emerging infectious diseases appear recurrently and represent a threat to global health security. Africa is particularly exposed to the risks of infectious epidemics, due to both the number of circulating infectious agen...Emerging infectious diseases appear recurrently and represent a threat to global health security. Africa is particularly exposed to the risks of infectious epidemics, due to both the number of circulating infectious agents, especially in wildlife, and the social and environmental factors that promote their epidemic spread. Ebola outbreaks in West Africa in 2014 and those in the DRC that began in 2018 were an opportunity to develop and deploy new diagnostic techniques in laboratories in Guinea and the Democratic Republic of the Congo (DRC). These tools made it possible to identify the infectious agent rapidly, to trace contamination chains in real time to enable effective interventions, and to develop a reliable serological tool for differential diagnoses. Today, equipped and functional facilities exist in both countries, led by Guinean and Congolese researchers trained to high levels of competence and benefiting from unique experience and field knowledge.
Sokhna C, Basséne H, Diatta G
… +11 more, Diagne N, Doucouré S, Diallo A, Ba EH, Fenollar F, Mediannikov O, Gautret P, Drancourt M, Lagier JC, Raoult D, Parola P
Med Sante Trop
· 2019 Nov · PMID 31884981
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In Senegal, we have developed technology-driven research based on observation and technology transfer especially in molecular biology, genomics, culturomics, and proteomics with the use of the first Maldi-TOF mass spectr...In Senegal, we have developed technology-driven research based on observation and technology transfer especially in molecular biology, genomics, culturomics, and proteomics with the use of the first Maldi-TOF mass spectrometer in clinical microbiology in Africa. This strategy is associated with a policy of training students from the South and helping them to return back. This technology transfer and expertise has enabled us to explore the causes of non-malarial fevers of unknown causes, with the study of the repertoire of infectious pathogens in humans and arthropod vectors, to diagnose infectious diseases in rural areas with Point of Care laboratories, to isolate new bacteria, and to study pathologies linked to mass gatherings. They have also allowed us to develop transdisciplinary research including the study of the microbiota in malnourished children. We wish to continue this technological development, which provides the foundation for high-level research in Senegal.
Cissé B, Fall Cissé NA, Hane AA
… +1 more, Touré Kane C
Med Sante Trop
· 2019 Nov · PMID 31884980
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To reduce congestion in its capital, Dakar, Senegal decided in 2012 to construct a new city in Diamniadio, in the suburbs. This new urban center, an integral part of the Emerging Senegal Plan (PSE), is a major first step...To reduce congestion in its capital, Dakar, Senegal decided in 2012 to construct a new city in Diamniadio, in the suburbs. This new urban center, an integral part of the Emerging Senegal Plan (PSE), is a major first step towards the organization of land use planning. The Institute for Health Research, Epidemiologic Surveillance and Training (Iressef) is one of the very first new operational buildings in this new city. Conceived and directed by Professor Souleymane Mboup, Iressef was made possible by the support of the government of Senegal and the GILEAD Foundation. The vision of its sponsors is to make it a hub of excellence for research in the domain of tropical infectious diseases, with expertise and technical equipment and facilities comparable to those in research institutes in developed countries. The existing platforms include, among others, several state-of-the-art laboratories, a health and demographic surveillance system covering a population of 30 000 inhabitants, a clinical trial center, a dynamic community participation program, and a training center. To achieve this vision in the short- and long-terms, Iressef has developed a strategic 5-year plan focusing on two principal objectives, that is: (i) to conduct research programs according to the strictest ethical standards, and (ii) to train an elite group of Senegalese and African scientists, competitive and capable of developing health research in Africa. To attain these objectives, international partners will play an essential role.
Med Sante Trop
· 2019 Nov · PMID 31884979
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By choosing a capacity-building strategy based on human resources, the late Professor Ogobara Doumbo and Professor Yeya Toure have succeeded in establishing a center devoted to malaria research in the economically unfavo...By choosing a capacity-building strategy based on human resources, the late Professor Ogobara Doumbo and Professor Yeya Toure have succeeded in establishing a center devoted to malaria research in the economically unfavorable environment of Mali. By taking advantage of the advent of a pluralist democracy in Mali in 1991, the Malaria Research and Training Centre (MRTC) has become a model of excellence in training in biomedical research and a renowned clinical research center. Since 2003, MRTC researchers have conducted more than 20 phase-1 and -2 clinical trials of antimalarial vaccines, thus becoming a reference both in Africa and globally. The MRTC owes its success to several factors. While the focus on human capacity building has been critical for sustainability, the quality of the partnerships and the density of the partnership network have also played a critical role. The NIH partnership enabled us to construct new buildings to house modern laboratories. These facilities made it possible to conduct leading-edge research programs, the results of which in turn provided access to significant other funding sources, not only to finance new projects, but also to purchase modern heavy equipment. Lastly, it has been possible to set up a policy for training Malian researchers at the Masters and PhD levels, with the aim of fueling a critical mass of scientific expertise. The combination of each of these factors has created an environment conducive to sustainable research and whose recent results have heightened expectations for a rich future.
Sako FB, Sylla AO, Diallo MOS
… +6 more, Touré A, Traoré FA, Tounkara TM, Chamkoue BW, Barry M, Cissé M
Med Sante Trop
· 2019 Aug · PMID 31573532
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In developing countries, tetanus remains a public health problem because of its frequency, severity, and still high mortality. The objective of this study was to describe the epidemiological profile of patients hospitali...In developing countries, tetanus remains a public health problem because of its frequency, severity, and still high mortality. The objective of this study was to describe the epidemiological profile of patients hospitalized for tetanus and to identify the factors associated with dying from it. This retrospective, descriptive, and analytical study reviewed hospital records of all patients, of all ages and genders who were treated for tetanus in our department over a 5-year period. Among 3549 patients during the study period, 75 had tetanus (2.11%), and 71 of them were included in our study. The median age of patients was 35 years (range: 11-70 years) with a male prevalence of 80%. The most frequently affected socio-professional categories were students (21.1%), farmers (18.3%), workers (15.5%), and shopkeepers and tradespeople (15.5%). The main entry points were post-traumatic (40.9%), cutaneous (33.8%), and post-surgical (16.90%). Paroxysm (95.8%), trismus (93.0%), generalized contracture (67.6%), and dysphagia (46.5%) were the most frequent signs. Among these cases, 40.9% were severe (40.85%), 49.3% moderate (49.30%), and 9.6% benign. We recorded 34 deaths (48%). Factors associated with death were age> 60 years (P = 0.01), fever (P = 0.01), hypertension (P = 0.02), and HIV infection (P = 0.01). Tetanus remains a frequent disease with high lethality. Death is associated with specific factors that should be taken into account in the criteria for assessing its prognosis.
Zeba Lompo S, Barogui Y, Compaore J
… +3 more, Ouedraogo Y, Kafando C, Kambire-Diarra MC
Med Sante Trop
· 2019 Aug · PMID 31573531
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Burkina Faso shares its borders with six countries that regularly report cases of Buruli ulcer, yaws, and leprosy (Hansen disease), three neglected tropical diseases with dermatological manifestations. Treatment of lepro...Burkina Faso shares its borders with six countries that regularly report cases of Buruli ulcer, yaws, and leprosy (Hansen disease), three neglected tropical diseases with dermatological manifestations. Treatment of leprosy has shown excellent results, and it appears to be essentially eliminated. The same cannot be said for Buruli ulcer or yaws, the epidemiology of which remains poorly elucidated. In this context, it was essential to review the situation of these three diseases through a joint survey in the health districts bordering the Côte d'Ivoire, Ghana and the irrigated areas around the dams of Kompienga and Bagré. Our team led a disease survey in these irrigated areas, and we report the results. To determine the current scale of the Buruli ulcer, leprosy, and yaws in the irrigated areas around these two dams and to formulate recommendations. This single-pass survey from April 10-18 was a transverse descriptive study, with sampling based on proximity to the dams. Overall, 1482 people were consulted. Among them, 413 (27.9%) presented dermatosis, distributed as follows: 28 suspected cases of yaws (6.8%), 7 suspected cases of Buruli ulcer (1.7%), 1 case of multibacillary leprosy (0.24%) in an 8-year-old girl, and 377 cases of other dermatoses, dominated by those of fungal origin. A large-scale investigation including all other irrigated areas might make it possible to understand the real situation.
Med Sante Trop
· 2019 Aug · PMID 31573530
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Publisher ↗
To determine the costs of the three types of delivery in the maternity department of the Tiznit Provincial Hospital Center. This quantitative study analyzed costs for the year 2016 by the activity-based costing method. T...To determine the costs of the three types of delivery in the maternity department of the Tiznit Provincial Hospital Center. This quantitative study analyzed costs for the year 2016 by the activity-based costing method. The total maternity ward costs were 6 269 922.31 MAD, of which 5 781 409,09 MAD (92.21%) were attributed to the three types of delivery studied. Human resources accounted for 53.56% of maternity department expenses, pharmaceutical expenses for 16.22%, and administrative expenses for 11.40%. The average costs of a normal delivery were 1257,76 MAD, for a dystocic delivery 1258,00 MAD, and for cesarean delivery 3004.87 MAD. This type of study is the first of its kind to be conducted in a Moroccan hospital. It demonstrates the feasibility of this approach, on the one hand, and on the other it provides managers with a much more accurate idea of the cost of the services offered and the information needed for decision-making.
Kambé Y, Ouattara A, Biérou Bodé T
… +3 more, Hyda J, Konaté S, Dembélé B
Med Sante Trop
· 2019 Aug · PMID 31573529
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Blood product suppliers have two options for blood collection: at fixed sites and mobile collection sites. Those preferring voluntary, unpaid donations must move ever closer to the population by organizing mobile collect...Blood product suppliers have two options for blood collection: at fixed sites and mobile collection sites. Those preferring voluntary, unpaid donations must move ever closer to the population by organizing mobile collection. The objective of this study was to analyze the impact of mobile collection in the production of the Côte d'Ivoire's CNTS. Our results, based on data from the CNTS from 2014 through 2016 and interviews with 22 managers of blood transfusion centers, confirm the increasing preponderance of this approach. Thus, our results raise the problem of blood safety in a context where the prevalence of transfusion-transmissible infections is higher in mobile collections, where most donors are giving blood for the first time.
Komboigo BE, Kiemtoré S, Kain DP
… +5 more, Zamané Y, Kaboré X, Zoundi M, Ouédraogo A, Thiéba B
Med Sante Trop
· 2019 Aug · PMID 31573528
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To study the sexual dysfunctions of women living with a partnerin relationship in the city of Ouagadougou. This was a descriptive, and analytical cross-sectional study collectedwith prospective data collection over the a...To study the sexual dysfunctions of women living with a partnerin relationship in the city of Ouagadougou. This was a descriptive, and analytical cross-sectional study collectedwith prospective data collection over the a period of seven (07-) months period from March 1st through November 30th, 2016,. by interviewing It consisted of collecting from 633 women living with a partner in relationship in Ouagadougou data aboutn their sex livfes. The data werehas been processed and analyzed with epi-info software, in version 3.5.3. Statistical tests (Chi-square and, Fisher's exact tests) were used to assess the association between the different variables at athe 5% significance level of 5%. The study participation rate was 90.8%. In our study, 84.5% (n=or 486) women reported having at least one sexual dysfunction in their lifetime. Of those surveyed, 84.5% (486/575) had anorgasmia, 64.3% (370/575) had dyspareunia, 35.8% (206/575) had an problems of arousalexcitement disorder, and 35.1% had (202/575) frigidity. In addition,There were 116 of them (20.3%) hadwith lowdecreased libidosexual desire and 0.7% (4/575) with vaginismus. Female circumcision was the main factor associated with the sexual dysfunction of the respondents. Dyspareunia was 4.2 times more common in women with genital excisioned women than in uncircumcised women The sSexual dysfunction is frequent amongof a womean living within a partnercouple in the city of Ouagadougou is frequent. Because excision is one of the factors [[[The leading factor]]] found in the occurrence of sexual dysfunction in women, hence the need to proscribe this harmful practice must be proscribed in our societies.
Med Sante Trop
· 2019 Aug · PMID 31573527
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Publisher ↗
Schistosomiasis (also known as bilharziosis) is a parasitic infection still endemic in Madagascar. Its transmission is perpetuated by population lifestyles in tropical countries. A genital location is relatively rare; di...Schistosomiasis (also known as bilharziosis) is a parasitic infection still endemic in Madagascar. Its transmission is perpetuated by population lifestyles in tropical countries. A genital location is relatively rare; diagnosis is histological. This is a retrospective, descriptive study of genital schistosomiasis observed in the anatomic pathology laboratory of Sampan'asa luteriana ho an'ny fahasalamana and the Joseph Ravoahangy Andrianavalona University Hospital Center over the 6-year period from January 2010 through December 2015. We collected 13 cases. The mean age of the patients was 31.6 years and ranged from 4 to 48 years. Localization was cervical (n = 10), tubo-ovarian (n = 2), and vulvar (n = 1). Clinical signs were isolated bleeding or associated with other signs for cervical localization, suspicion of cyst for the vulva, and suspicion of mass for the ovary. The diagnosis was based on the presence of schistosome eggs in all cases, associated with tuberculoid granulomas (n = 9), eosinophilic polynuclear cells (n = 1), and giant cells (n = 2). We observed one case of squamous cell carcinoma that developed on cervical schistosomiasis. Schistosomiasis is a neglected tropical diseases. Malignant transformation is possible. A cervical hemorrhage is not synonymous with cancer but may reveal a specific inflammatory lesion. Histological examination is necessary for diagnosis.
Med Sante Trop
· 2019 Aug · PMID 31573526
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Publisher ↗
Human papillomavirus (HPV) is the leading cause of cervical cancer, which in turn is the leading cause of cancer death in women in Africa. The objective of this study was to determine the prevalence of high-risk HPV infe...Human papillomavirus (HPV) is the leading cause of cervical cancer, which in turn is the leading cause of cancer death in women in Africa. The objective of this study was to determine the prevalence of high-risk HPV infection (HR-HPV) and the distribution of genotypes encountered in the sexually active female population of Ouagadougou. In four level-two health centers, we recruited 234 women who agreed to undergo an endocervical swab. HR-HPV genotypes were identified by real-time PCR. The Chi-square test was used for comparisons, with significance defined by a P-value < 0.05. The prevalence of HR-HPV infection was 52.56%. Fourteen genotypes corresponding to 216 infections were characterized: HPV 59 (42/216), HPV 66 (30/216), HPV 56 (20/216), HPV 45 (20/216), HPV 58 (18/216), HPV 39 (18/216), HPV 51 (16/216), HPV 68 (14/216), HPV 52 (12/216), HPV 18 (12/216), HPV 35 (6/216), HPV 31 (5/216), HPV 16 (3/216), HPV 33 (0/216). HPV infection was statistically associated with age (P = 0.033) and with some specific sexual practices, such as oral sex (P = 0.001). The prevalence of HR-HPV infection among women without lesions in our study is higher than that reported previously in studies conducted in Ouagadougou among women in the general population and those found in the rest of the world. Moreover, HPV16 and 18 were not the genotypes most frequently encountered.
Sadio AJ, Gbeasor-Komlanvi FA, Konu YR
… +7 more, Sewu EK, Zida-Compaore W, Salou M, Kariyiare BG, Blatome TJ, Dagnra AY, Ekouevi DK
Med Sante Trop
· 2019 Aug · PMID 31573525
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Publisher ↗
Men who have sex with men (MSM) are a population at risk of contracting both HIV and hepatitis B virus (HBV). The objective of this study was to assess the prevalence of these diseases and the factors associated with the...Men who have sex with men (MSM) are a population at risk of contracting both HIV and hepatitis B virus (HBV). The objective of this study was to assess the prevalence of these diseases and the factors associated with them among MSM in Togo in 2017. This cross-sectional study took place in eight major cities in Togo from August through September, 2017. MSM aged 18 years and older were recruited with the respondent-driven sampling method. Data on sexual behavior were collected with a standardized questionnaire. Rapid tests were used to screen for HIV and HBV. In all, 678 MSM with a median age of 23 years (interquartile range: 21-26) were recruited, 68.7% of them living in Lomé, the capital of Togo. The prevalence of HIV was 22.0% (95% confidence interval [95% CI] 18.9-25.3) and that of HBV 7.1% (95% CI 5.3-9.3). Seven (1.0%) MSM were co-infected with HIV and HBV. Age, place of residence, living with a male partner, the number of male partners in the 12 months before the study, and history of HIV testing were associated with HIV infection (P<0.05). Age and living in Lomé were associated with HBV infection (P<0.05). The results of this study highlight the importance of focusing response efforts on populations at risk of contracting STIs through routine screening and vaccination.
Assoumou AA, Bekelynck A, Carillon S
… +5 more, Kouadio BA, Ouantchi H, Doumbia M, Larmarange J, Koné M
Med Sante Trop
· 2019 Aug · PMID 31573524
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Publisher ↗
Since the early 2010s, the President's Emergency Plan for AIDS Relief (Pepfar) and the Global Fund to Fight AIDS, Tuberculosis and Malaria have stiffened their result-based management strategies. Disbursement conditions...Since the early 2010s, the President's Emergency Plan for AIDS Relief (Pepfar) and the Global Fund to Fight AIDS, Tuberculosis and Malaria have stiffened their result-based management strategies. Disbursement conditions are increasingly demanding for funded NGOs (achievement of quantified objectives, frequent reporting, and monitoring of activities), and their remuneration depends on the results achieved. This article aims to analyze the effects of this strengthening of policies based on New Public Management on local implementation of activities, based on the example of community-based HIV testing. In three health districts of Côte d'Ivoire, in 2015 and 2016, we mapped the actors involved in community-based HIV testing and conducted semi-directive interviews with members of the community-based NGOs (n = 18). The funding of local HIV testing organizations is channeled through intermediary organizations according to a complex pyramid system. This, combined with cumbersome activity reporting and data validation, results in delays in the disbursement of funds and significantly reduces the actual time available to implement activities, i.e., to less than half the time planned for this purpose. This managerialization -of both Pepfar and the Global Fund - produces the counterproductive effects against which it was supposed to fight.
Med Sante Trop
· 2019 Aug · PMID 31573523
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Publisher ↗
This review assesses the effectiveness of interventions to improve Prevention of Mother-to-Child Transmission (PMTCT) retention and adherence to treatment in Sub-Saharan Africa since the adoption of Option B +. PubMed, C...This review assesses the effectiveness of interventions to improve Prevention of Mother-to-Child Transmission (PMTCT) retention and adherence to treatment in Sub-Saharan Africa since the adoption of Option B +. PubMed, Cochrane, African Index Medicus and the graey literature were used to select articles that used as endpoints whose judgement criteria were retention in the PMTCT circuit and compliance with antiretroviral ARV treatment. Only studies with a comparison group published in or after from 2013 were eligible. Fourteen studies meeting the eligibility criteria were included. Nine studies have a high or moderate level of GRADE evidence. Six studies assessing retention in the PMTCT circuit showed significantly betterhigher outcomes for the intervention group: peer support (n = 1), couple screening (n = 1), text message use (n = 1), financial transfer (n = 1) and integration of maternal and child health services (n = 2). Integration of maternal and child health services, peer support within the community, involvement of male partners, and the use of mobile health techniques can improve PMTCT indicators.
Kabuya MS, Mukuku O, Van Geertruyden JP
… +4 more, Mutombo AM, Luboya ON, Wembonyama SO, Lutumba P
Med Sante Trop
· 2019 Aug · PMID 31573522
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Publisher ↗
Diarrheal diseases are one of the leading causes of death among children younger than 5 years of age in the world in general and in sub-Saharan Africa in particular. Mothers are predominantly responsible for child care a...Diarrheal diseases are one of the leading causes of death among children younger than 5 years of age in the world in general and in sub-Saharan Africa in particular. Mothers are predominantly responsible for child care and housekeeping in this region. The objective of this study was to determine the prevalence of diarrhea and identify its maternal determinants in children under five in the city of Lubumbashi. A cross-sectional study conducted throughout March 2018 collected data from 299 mothers through a household survey. A pretested structured questionnaire was used to collect data in face-to-face interviews. The prevalence of diarrhea in children under 5 in Lubumbashi was 35.8%. In the univariate analysis, the variables associated with diarrhea were single motherhood, soap-free handwashing after latrine use, and the presence of feces around the latrines. Multivariate analysis revealed that the presence of feces around latrines (OR adjusted = 2.12 [1.18-3.80]) was associated with diarrhea. Defective cleaning by mothers, specifically their failure to keep latrine areas clean and free of feces, is associated with the risk of diarrhea in children under five in the study area. A hygiene intervention program must be designed to promote healthy behavior to alleviate the burden of diarrhea in children.
Med Sante Trop
· 2019 Aug · PMID 31573521
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Publisher ↗
This study assessed the prevalence of schistosomiasis among 307 schoolchildren aged from 7 to 17 years at various schools in four districts in the Rosso region. Hematuria was observed among 17.5% (54/307) and Schistosoma...This study assessed the prevalence of schistosomiasis among 307 schoolchildren aged from 7 to 17 years at various schools in four districts in the Rosso region. Hematuria was observed among 17.5% (54/307) and Schistosoma hematobium eggs were found among 15.6% (48/307). We observed the highest prevalence rates (P = 0.003) among schoolchildren in the districts of Breun (19.75% ± 0.09), Tounguen (18.66% ±0.08) and PK 7 (18.42 % ±0.08). The statistical analysis showed that the differences in the prevalence, hematuria rate, and parasite load did not differ significantly by the schoolchildren's age and sex (P > 0.05). Schoolchildren in Demeldek were significantly (P = 0.003) less infested (5.33% ± 0.11) than those in the other districts. The parasite load ranged from 6 to 15 eggs/10 ml of urine. The malacological investigations conducted at the water points of each village visited showed the presence of Bulinus truncatis, Bulinus forskalii, Lymnaea natalanis, Biomphalariae feifferi and Melanoides tuberculata. These results show that schistosomiasis poses a public health problem in the region. To eradicate this parasitosis, it will be necessary to conduct more detailed malacological studies and combine several types of preventive actions.
Togo P, Togo B, Doumbia AK
… +14 more, Traoré F, Touré A, Diakité AA, Coulibaly O, Diall H, Maïga B, Dembélé A, Sacko K, Cissé ME, Coulibaly YA, Konaté D, Kanikomo D, Traoré CB, Sylla M
Med Sante Trop
· 2019 Aug · PMID 31573520
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Publisher ↗
to assess epidemiologic and clinical aspects of childhood brain tumors in Mali. a retrospective, descriptive study of children aged 0-15 years with brain tumors, conducted in the pediatrics department of the Gabriel Tour...to assess epidemiologic and clinical aspects of childhood brain tumors in Mali. a retrospective, descriptive study of children aged 0-15 years with brain tumors, conducted in the pediatrics department of the Gabriel Touré University Hospital Center in Bamako, Mali, from January 31, 2007 to December 3, 2012. In all, 41 cases of brain tumors were recorded during this period (mean: 5.5 years old; range: 1-12 years). Brain tumors were most frequent in the children aged 2-5 years (53.7%) and among boys (53.7%). Late stage at presentation was relatively frequent (34.1%) with a mean time to diagnosis of 10 months. Features of elevated intracranial pressure were the most frequent mode of revelation of primary tumors (26.8%). Supratentorial tumors accounted for 83% of the cases, and gliomas were most frequently (29.3%) identified on computed tomography. Only five patients underwent surgical tumor removal. A broader study including the other hospitals in Bamako could help to assess more accurately the epidemiology of pediatric brain tumors in Mali.