American Journal Of Translational Research[JOURNAL]
Sun
200 papers
FBXO31-induced ABL2 ubiquitination increases cystine-glutamate antiporter-mediated ferroptosis and inhibits malignant progression in triple-negative breast cancer.
Zhang Y, Luo J, Xu Q … +7 more , Zeng X, Wang X, Xu H, Pan X, Cao T, Huang H, Ma J
Am J Transl Res · 2026 · PMID 42170439 · Full text
F-box only protein 31 (FBXO31) has been implicated in tumorigenesis and development across various human cancers. However, the role of FBXO31 in breast cancer progression remains poorly understood. In this study, we iden...
F-box only protein 31 (FBXO31) has been implicated in tumorigenesis and development across various human cancers. However, the role of FBXO31 in breast cancer progression remains poorly understood. In this study, we identified FBXO31 as a tumor suppressor in triple-negative breast cancer (TNBC), where it inhibited cell proliferation, migration, and invasion. Furthermore, FBXO31 promoted cystine-glutamate antiporter (xCT)-mediated ferroptosis in TNBC cells. Notably, overexpression of FBXO31 suppressed tumor growth in mice. Mechanistically, ABL-related gene (ABL2) was identified as a novel ubiquitin substrate of FBXO31. FBXO31 specifically interacted with ABL2 and promoted ABL2 ubiquitination and subsequent degradation through its F-box motif. Functionally, ABL2 acted as an oncogenic factor in TNBC cells by promoting cell proliferation, migration, and invasion, while inhibiting xCT-mediated ferroptosis. Rescue experiments showed that FBXO31 inhibited TNBC progression at least partly through down-regulating ABL2 expression. Collectively, our findings reveal a novel molecular mechanism for TNBC progression and provide a potential therapeutic strategy for its treatment.
A novel disposable intrauterine infusion catheter reduces pain and shortens procedure time compared to a conventional balloon-tipped catheter in sonohysterography: a retrospective cohort study.
Ruan L, Yang L
Am J Transl Res · 2026 · PMID 42170438 · Full text
OBJECTIVE: To compare pain scores and complication rates between a novel disposable intrauterine infusion catheter (Yikai Medical) and a conventional balloon-tipped 12F double-lumen catheter during hysterosalpingo-contra...
OBJECTIVE: To compare pain scores and complication rates between a novel disposable intrauterine infusion catheter (Yikai Medical) and a conventional balloon-tipped 12F double-lumen catheter during hysterosalpingo-contrast sonography (HyCoSy). METHODS: This single-center retrospective cohort study included 128 infertile women who underwent HyCoSy between January 2022 and June 2023. Patients were divided into observation group (disposable catheter, n = 64) and control group (balloon catheter, n = 64). Primary outcomes were Visual Analog Scale (VAS) pain scores (intraoperative, 30 min, 2 h postoperative) and complication rates. Secondary outcomes included procedure time and imaging success rate. Multivariate logistic regression was used to identify independent predictors of pain. RESULTS: Baseline characteristics were generally comparable between the groups, although patients in the observation group were slightly younger (P = 0.041). VAS scores were significantly lower in the observation group at all time points (all P<0.001). Overall complication rate was lower in the observation group (15.6% vs. 29.7%) but not statistically significant (P = 0.091). Procedure time was shorter in the observation group (8.28 ± 1.44 vs. 10.49 ± 2.32 min, P<0.001). Imaging success was similar (100% vs. 98.4%, P = 1.000). Catheter type was an independent predictor of moderate-to-severe pain (OR = 0.115, 95% CI 0.050-0.267, P<0.001). CONCLUSION: The disposable intrauterine infusion catheter significantly reduces pain and procedure time during HyCoSy compared to the conventional balloon-tipped catheter, with comparable imaging success and a trend toward fewer complications.
Efficacy evaluation and mechanism exploration of Dachaihu Decoction in treating hyperlipidemia: an integrated network meta-analysis and network pharmacology study.
Bu W, Li H, Zhu S … +3 more , Liu Y, Xia Y, Liu F
Am J Transl Res · 2026 · PMID 42170437 · Full text
BACKGROUND: Dachaihu Decoction (DCHD), a traditional herbal formula from Shanghan Lun, has been widely used in the management of hyperlipidemia. However, the comparative efficacy of its modified formulations and their un...
BACKGROUND: Dachaihu Decoction (DCHD), a traditional herbal formula from Shanghan Lun, has been widely used in the management of hyperlipidemia. However, the comparative efficacy of its modified formulations and their underlying mechanisms remain unclear. This study aimed to evaluate the therapeutic efficacy of DCHD and its modifications and to elucidate the potential mechanisms using integrated analytical strategies. METHODS: We conducted a Bayesian network meta-analysis (NMA) of randomized controlled trials (RCTs) systematically retrieved from multiple databases up to May 2024, following the PRISMA-NMA Guidelines. Lipid parameters, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), as well as response rates, were evaluated. In addition, network pharmacology, molecular docking, and molecular dynamics (MD) simulations were performed to further explore the underlying mechanisms. RESULTS: A total of 23 randomized controlled trials (RCTs) involving 1,816 patients were included. The surface under the cumulative ranking curve (SUCRA) analysis indicated that Dachaihu Decoction combined with Shengjiang Powder had the highest efficacy in reducing TC, TG, and LDL-C in patients with hyperlipidemic pancreatitis. However, sensitivity analysis revealed that Dachaihu Decoction alone and in combination with Guizhi Fuling Pill showed more stable efficacy in chronic populations. Network pharmacology identified 69 active components, including quercetin, β-sitosterol, and baicalein, and 305 intersecting targets. Protein-protein interaction (PPI) analysis highlighted TLR4, MMP9, SIRT1, ICAM1, and GSK3B as core targets. KEGG pathway enrichment analysis indicated significant involvement in lipid metabolism and inflammatory pathways. Molecular docking and molecular dynamics simulations revealed that the β-sitosterol-ICAM1 complex exhibited stable conformational stability, with an MM-GBSA binding free energy of -37.09 kcal/mol. CONCLUSIONS: Modified DCHD formulations showed therapeutic potential for hyperlipidemia through multi-target and multi-pathway synergistic mechanisms. DCHD combined with Shengjiang Powder appears particularly promising in hyperlipidemic pancreatitis, whereas DCHD alone shows stable efficacy in chronic populations. These findings provide robust evidence supporting the rational clinical application and modern pharmacological interpretation of the classical formula DCHD documented in Shanghan Lun.
Clinical efficacy of percutaneous transhepatic biliary drainage for obstructive jaundice in pancreatic cancer and risk factors for postoperative pancreatitis.
Meng Y, Li Y, Yang J … +2 more , Yao W, Zhang Y
Am J Transl Res · 2026 · PMID 42170436 · Full text
OBJECTIVE: To investigate the clinical efficacy of percutaneous transhepatic biliary drainage (PTBD) for obstructive jaundice in pancreatic cancer and identify the independent risk factors for postoperative pancreatitis...
OBJECTIVE: To investigate the clinical efficacy of percutaneous transhepatic biliary drainage (PTBD) for obstructive jaundice in pancreatic cancer and identify the independent risk factors for postoperative pancreatitis after PTBD. METHODS: A retrospective cohort study included 145 consecutive patients with pancreatic cancer admitted to Shanghai Seventh People's Hospital from June 2022 to June 2024, assigned to either the endoscopic retrograde biliary drainage (ERBD, n=72) group or the PTBD (n=73) group. The PTBD group was further subdivided into pancreatitis (n=11) and non-pancreatitis (n=62) subgroups. Clinical data were compared between groups. Univariate and Firth multivariate logistic regression analyses identified independent factors, with ROC curves evaluating predictive value. RESULTS: Baseline data were balanced between groups (all P>0.05). PTBD yielded more significant improvements in liver function and a shorter jaundice resolution time (all P<0.05), yet was associated with a significantly higher incidence of postoperative pancreatitis (P<0.05). High body mass index (BMI), Oddi sphincter dysfunction, and difficult intubation were independent risk factors (P<0.05), while external drainage was a protective factor (OR=0.064, P=0.023). A multivariate combined predictive model constructed from these factors exhibited excellent predictive efficacy (area under the curve (AUC) =0.960, 95% CI: 0.918-1.000). CONCLUSION: PTBD effectively relieves obstructive jaundice and improves liver function. High-risk patients (elevated BMI, Oddi sphincter dysfunction, difficult intubation) require close monitoring, and prioritizing external drainage may reduce postoperative pancreatitis risk.
Efficacy of SWIM technology combined with direct aspiration first pass technique for large vessel occlusion in acute ischemic stroke.
Wang D, Zhang F, Zhang Z … +4 more , Qiu H, Zhou W, Li H, Zhang Y
Am J Transl Res · 2026 · PMID 42170435 · Full text
OBJECTIVE: To evaluate the safety and efficacy of Solitaire Flow Restoration stent retriever with intracranial support catheter for mechanical thrombectomy (SWIM) combined with direct aspiration first pass technique (ADA...
OBJECTIVE: To evaluate the safety and efficacy of Solitaire Flow Restoration stent retriever with intracranial support catheter for mechanical thrombectomy (SWIM) combined with direct aspiration first pass technique (ADAPT) for acute large vessel occlusive stroke (AIS-LVO). METHODS: A retrospective analysis was conducted on AIS-LVO patients admitted to the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from April 2021 to April 2022. The patients were divided into an observation group (n=68), who received ADAPT combined with SWIM, and a control group (n=67), who received SWIM only. The time from puncture to recanalization, postoperative vascular recanalization rate, National Institutes of Health Stroke Scale (NIHSS) and Barthel Index scores, and good prognosis rate at 90 days after surgery were compared between the two groups. RESULTS: There was no significant difference in the reperfusion rate or time from puncture to reperfusion between the two groups ( > 0.05). The observation group had a significantly higher rate of excellent and good prognosis at 90 days post-surgery compared to the control group (58.82% vs. 32.84%; χ=6.672, =0.010). Significant differences were found between the two groups in NIHSS scores (6.58±1.47 . 5.63±1.0; t=2.874, P=0.010) and Barthel Index scores (72.35±8.77 . 76.43±7.83; t=3.120, < 0.001). Surgical approach, ≥ 2 thrombectomy passes, and puncture-to-recanalization time ≥ 60 min were identified as predictive factors for prognosis. CONCLUSION: ADAPT combined with SWIM is safe and effective for AIS-LVO and may improve clinical prognosis.
Efficacy and safety of pyrotinib combined with trastuzumab and chemotherapy in patients with HER2-positive locally advanced breast cancer: a multicenter real-world study.
Zhang Y, Yang C, Jia Y … +11 more , Luo R, Wang J, Han M, Liu Y, Wang X, Shi L, Yang J, Yu L, Zhang W, Niu F, Ma L
Am J Transl Res · 2026 · PMID 42170434 · Full text
OBJECTIVES: This multicenter real-world investigation aimed to assess the outcomes resulting from the incorporation of pyrotinib into trastuzumab and chemotherapy regimens for the neoadjuvant treatment of individuals dia...
OBJECTIVES: This multicenter real-world investigation aimed to assess the outcomes resulting from the incorporation of pyrotinib into trastuzumab and chemotherapy regimens for the neoadjuvant treatment of individuals diagnosed with HER2-positive locally advanced breast cancer (LABC). METHODS: A multicenter retrospective cohort analysis was carried out, including patients diagnosed with HER2-positive locally advanced breast cancer from nine medical institutions in Hebei Province, China. Participants were enrolled from January 2023 to June 2023 and followed until December 2025. Based on the neoadjuvant therapy received, patients were divided into two groups: trastuzumab plus chemotherapy (n=127) and pyrotinib plus trastuzumab and chemotherapy (n=101). The main assessment criterion focused on the rate of total pathological complete response (tpCR). Among the secondary evaluation metrics were the breast pathological complete response (bpCR) rate, the objective response rate (ORR), progression-free survival (PFS), overall survival (OS), as well as adverse events related to the treatment. RESULTS: A total of 228 patients were analyzed. The pyrotinib group showed significantly higher tpCR rate (46.53% vs. 31.50%, =0.020), bpCR rate (51.49% vs. 35.43%, =0.015), and ORR (88.12% vs. 77.17%, =0.032) compared with the trastuzumab-only group. Time to initial response was shorter (6.24 vs. 7.84 weeks, <0.001), and PFS was prolonged (21.06 vs. 18.68 months, <0.001) in the pyrotinib group. However, higher incidences of diarrhea (72.28% vs. 21.26%, <0.001), rash (28.71% vs. 9.45%, <0.001), and hematological toxicities were observed. CONCLUSIONS: In a real-world setting the addition of pyrotinib to trastuzumab and chemotherapy significantly improved pathological and radiographic responses and prolonged PFS, albeit with an increased but manageable toxicity profile.
Research progress on risk factors and early predictors of contrast-induced nephropathy.
Ma Y, Liao W, Zhao L
Am J Transl Res · 2026 · PMID 42170433 · Full text
As a serious iatrogenic complication, the incidence and clinical importance of contrast-induced nephropathy (CIN) have become increasingly prominent. CIN not only increases the length of hospital stay, medical cost and s...
As a serious iatrogenic complication, the incidence and clinical importance of contrast-induced nephropathy (CIN) have become increasingly prominent. CIN not only increases the length of hospital stay, medical cost and short-term mortality, but also is an independent predictor of long-term renal function deterioration and adverse cardiovascular events. At present, there is no effective method to completely avoid the occurrence of CIN after the use of contrast media in clinical practice, and the treatment of CIN that has occurred is also limited. Therefore, the prevention of CIN has become the focus of clinical research, and the identification of the risk factors of CIN is the basis and key link in the development of prevention programs. The purpose of this study is to review the existing evidence and further study the pathogenesis, risk factors and early predictors of CIN, so as to provide a reference for medical staff to formulate preventive measures, thereby reducing the risk of CIN and improving medical quality and ensuring patient safety.
Balloon dilatation combined with thrombectomy reduces myocardial injury in massive pulmonary embolism.
Zheng Y, Deng J, Zhou S … +7 more , Cao C, Chen G, Li S, Ye M, Deng L, Li L, Li H
Am J Transl Res · 2026 · PMID 42170432 · Full text
OBJECTIVES: To investigate the alterations in myocardial injury markers following balloon dilatation combined with thrombectomy in patients with massive pulmonary embolism (MPE). METHODS: A retrospective study was conduc...
OBJECTIVES: To investigate the alterations in myocardial injury markers following balloon dilatation combined with thrombectomy in patients with massive pulmonary embolism (MPE). METHODS: A retrospective study was conducted in 90 patients diagnosed with MPE. Clinical efficacy, Miller scores, pulmonary artery pressure (PAP), pulmonary artery diameter (PAD), and levels of myocardial injury markers were evaluated and compared between the combined treatment group (balloon dilatation plus thrombectomy) and the basic treatment group (basic therapy alone). RESULTS: Compared to the basic treatment group, the combined treatment group exhibited significantly improved clinical efficacy, including higher rates of complete response, marked response, and overall response. Hemodynamic and cardiac function indices were significantly improved, as evidenced by lower post-treatment Miller score, PAP, PAD, and right ventricular/left ventricular (RV/LV) ratios. Myocardial injury and inflammation-related indicators, including myoglobin (MYO), troponin T (TnT), creatine kinase (CK), and fibrinogen (FIB) were significantly reduced at specific time points in the combined treatment group. Furthermore, significant correlations were identified between injury markers and arterial blood gas indices: CK at 24 hours was inversely correlated with arterial partial pressure of carbon dioxide (PaCO), and TnT at 72 hours was negatively associated with arterial partial pressure of oxygen (PaO). CONCLUSION: Balloon dilation combined with thrombectomy for the treatment of MPE can significantly reduce myocardial injury and inflammation-related indicators, thereby markedly improving clinical outcome.
Ventilation mode effect on weaning outcome in COPD with type II respiratory failure.
Wu Y, Qing Z, Wei N … +3 more , Sun J, Dong L, Zhao K
Am J Transl Res · 2026 · PMID 42170431 · Full text
OBJECTIVE: To compare adaptive support ventilation (ASV) with synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV+PSV) in patients with chronic obstructive pulmonary disease (COPD) and...
OBJECTIVE: To compare adaptive support ventilation (ASV) with synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV+PSV) in patients with chronic obstructive pulmonary disease (COPD) and type II respiratory failure, and to identify predictors of weaning failure. METHODS: This retrospective study classified patients into ASV and SIMV+PSV groups based on ventilation mode received. We collected blood gas values, respiratory mechanics (peak inspiratory pressure [Ppeak], plateau pressure [Pplat], mean airway pressure [Pmean]), pulmonary function indices, and clinical outcomes. Pulmonary function was not measured during invasive mechanical ventilation. Baseline values were obtained from stable pre-intubation records, and post-treatment values were assessed after successful extubation in awake, cooperative, and clinically stable patients. Firth-corrected logistic regression identified independent predictors of weaning failure. RESULTS: Both groups showed similar improvements in blood gas values. ASV achieved greater reductions in Ppeak, Pplat, and Pmean, and larger improvements in forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEFR), which were assessed after successful extubation, compared to SIMV+PSV (all P<0.001). The ASV group had lower ventilator-associated pneumonia (VAP) incidence (P=0.023), reintubation rate (P=0.042), and weaning failure rate (P=0.007); in-hospital mortality did not differ. Higher Acute Physiology and Chronic Health Evaluation II (APACHE II) score, pre-treatment arterial carbon dioxide tension (PaCO), pre-treatment Pplat, and SIMV+PSV mode independently increased weaning failure risk, whereas higher pre-treatment pH and FEV were protective (all P<0.05). CONCLUSION: ASV reduced airway pressures, improved post-extubation pulmonary function, and was associated with fewer VAP events, reintubations, and weaning failures than SIMV+PSV in COPD patients with type II respiratory failure.
Bidirectional causal relationship between rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study.
Xu W, Wang Z, Li J … +4 more , Deng X, Feng C, Li J, Yu J
Am J Transl Res · 2026 · PMID 42170430 · Full text
BACKGROUND: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic, autoimmune inflammatory diseases. Although overlapping clinical and genetic features have been reported, the presence of a direct...
BACKGROUND: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic, autoimmune inflammatory diseases. Although overlapping clinical and genetic features have been reported, the presence of a direct causal relationship between them remains uncertain. METHODS: A bidirectional two-sample Mendelian randomization (MR) analysis was performed using genetic variants as instrumental variables to evaluate potential causal associations between RA and SLE. Sensitivity analyses were performed to assess heterogeneity, horizontal pleiotropy and the robustness of the findings. RESULTS: Genetically predicted RA did not have a significant causal effect on susceptibility to SLE. Conversely, genetically predicted SLE did not demonstrate a significant causal effect on RA risk. Sensitivity analyses supported the stability and reliability of these findings, with no evidence of substantial heterogeneity or directional pleiotropy. CONCLUSION: We concluded that RA and SLE may share genetic susceptibility and environmental triggers without a unidirectional causal relationship.
Association between mandibular third molar impaction pattern and mandibular crowding severity: a retrospective radiographic study.
Wang Y, Zhu L, Wang L … +1 more , Fan W
Am J Transl Res · 2026 · PMID 42170429 · Full text
OBJECTIVE: This study analyzed mandibular third molar (M3M) impaction and its link to mandibular crowding. METHODS: This retrospective study included 351 M3M patients (Oct 2023-Oct 2024), with 320 analyzed after exclusio...
OBJECTIVE: This study analyzed mandibular third molar (M3M) impaction and its link to mandibular crowding. METHODS: This retrospective study included 351 M3M patients (Oct 2023-Oct 2024), with 320 analyzed after exclusion. Outcome measures included mandibular full dentition crowding (MFDC), retromolar space of the mandible (RSM), impaction angle of the mandibular third molar (IAM3M), crown width of the mandibular third molar (CW-M3), eruption height of the mandibular third molar (EH-M3), adjacent distance between the mandibular second and third molars (AD-M2M3), and root curvature of the mandibular third molar (RC-M3). Spearman correlation and linear regression identified risk factors for mandibular crowding. Receiver operating characteristic (ROC) analysis evaluated radiographic indicators' predictive value for severe crowding (>8 mm). RESULTS: Among 320 subjects, 487 impacted M3M were identified, 53.39% mesial, 20.12% horizontal, 16.22% vertical, 5.75% distal, and 4.52% buccal/lingual. Crowding severity was mild (34.38%), moderate (44.06%), and severe (21.56%). Severe crowding was most frequent in mesial (60.9%) and horizontal (26.1%) impactions, with other types below 10%. One-way ANOVA showed MFDC, IAM3M, CW-M3, and EH-M3 decreased, mesial > horizontal > distal > vertical > buccal/lingual (all <0.05); RSM, AD-M2M3, and RC-M3 increased in the same sequence (all <0.05). Spearman analysis revealed positive correlations between impaction type and MFDC (<0.001). Linear regression identified mesial impaction, horizontal impaction, IAM3M>30°, and RSM<2.5 mm as independent risk factors for crowding (all <0.05). IAM3M had the best predictive value for severe crowding (AUC=0.749, 95% CI: 0.703-0.795), followed by RSM (AUC=0.719, 95% CI: 0.665-0.773). CONCLUSION: M3M impaction worsens mandibular crowding, which offers clinical guidance.
Predictive value of systemic inflammatory response index for the occurrence and prognosis of lung metastases in papillary thyroid carcinoma.
Chen J, Jiang H, Hou X … +2 more , Zhu Y, Li Z
Am J Transl Res · 2026 · PMID 42170428 · Full text
OBJECTIVE: To investigate the predictive value of the systemic immune-inflammation index (SIRI) for the timing and prognosis of lung metastases in patients with papillary thyroid carcinoma (PTC) post-surgery and before t...
OBJECTIVE: To investigate the predictive value of the systemic immune-inflammation index (SIRI) for the timing and prognosis of lung metastases in patients with papillary thyroid carcinoma (PTC) post-surgery and before the first I ablation therapy. METHODS: This retrospective study collected clinical data from 234 outpatients who underwent total or subtotal thyroidectomy followed by their first I ablation therapy. Patients were divided into two groups: a lung metastasis group (n=78) and a PTC control group (n=156). The optimal cutoff value for SIRI in the development of lung metastases was determined using receiver operating characteristic (ROC) curves. The 78 patients with lung metastases were further divided into a high SIRI group (n=60) and a low SIRI group (n=18). RESULTS: Statistically significant differences were found between the groups in terms of SIRI, pre-ablation thyroglobulin (Ps-Tg), maximum tumor diameter, and whether the tumor was multifocal (all P<0.05). Patients with higher SIRI values, higher Ps-Tg levels, larger main tumors, and more multiple tumors were more likely to develop lung metastases (all P<0.05). SIRI was effective in diagnosing lung metastases in patients with PTC, with an area under the curve (AUC) of 0.834 and an optimal cutoff value of 0.64. Overall, in all cases, the disease control rate and progression-free survival were significantly higher in the low-SIRI group than in the high-SIRI group (both P<0.05). CONCLUSION: SIRI prior to the first I treatment has good predictive value for the occurrence of postoperative lung metastases and prognosis in PTC patients.
SKA3 promotes cell growth and metastasis and is associated with poor prognosis in patients with esophageal cancer.
Yang H, Xu HL, Guo Q … +4 more , Fan JH, Zhang YS, Guo JL, Liang HL
Am J Transl Res · 2026 · PMID 42170427 · Full text
OBJECTIVES: Overexpression of Spindle and Kinetochore Associated complex subunit 3 (SKA3) has been strongly implicated in tumor prognosis, proliferation, and metastasis in various cancers. However, its role in esophageal...
OBJECTIVES: Overexpression of Spindle and Kinetochore Associated complex subunit 3 (SKA3) has been strongly implicated in tumor prognosis, proliferation, and metastasis in various cancers. However, its role in esophageal cancer (ESCA) remained unexplored. This study aims to investigate the function of SKA3 in ESCA. METHODS: The expression and prognostic value of SKA3 in ESCA were analyzed through bioinformatics, followed by experimental validation using clinical tissue samples from our hospital. Functional assays were performed to elucidate the role of SKA3 in promoting ESCA cell proliferation and migration. Additionally, the relationship between SKA3 expression and the tumor immune microenvironment was examined. RESULTS: SKA3 was significantly overexpressed in ESCA, with its elevated expression strongly correlating with key clinical features such as Barrett's esophagus, deeper tumor infiltration, lymph node metastasis, advanced pathologic stage, and poor prognosis. Genes co-expressed with SKA3 were enriched in processes related to cell division, DNA replication, the cell cycle, and the p53 signaling pathway. Knockdown of SKA3 significantly reduced ESCA cell proliferation and migration. Moreover, SKA3 overexpression was associated with higher stromal, immune, and ESTIMATE scores. CONCLUSION: SKA3 contributes to poor prognosis and modulates the immune microenvironment in ESCA. Inhibition of SKA3 expression effectively suppressed tumor growth and metastasis.
Significance of surgical margin width versus anatomical resection for hepatocellular carcinoma.
Liu P, Zhao T, Shi Y … +2 more , Yang N, Zhu JN
Am J Transl Res · 2026 · PMID 42170426 · Full text
OBJECTIVES: Extensive research has examined the survival benefits of anatomical resection versus wide surgical margins in hepatocellular carcinoma (HCC). Yet how to choose between them in practice remains unsettled. We t...
OBJECTIVES: Extensive research has examined the survival benefits of anatomical resection versus wide surgical margins in hepatocellular carcinoma (HCC). Yet how to choose between them in practice remains unsettled. We therefore investigated whether tumor size could inform this surgical decision. METHODS: We retrospectively analyzed 302 patients with HCC who underwent curative liver resection at three centers between December 2009 and December 2010. Patients were divided into two groups according to tumor diameter: ≤3 cm (n=104) and >3 cm (n=198). Baseline clinicopathologic characteristics and longterm oncologic outcomes were compared between the two groups. We also assessed how surgical margin width (≥1 cm vs. <1 cm) and anatomical resection influenced overall survival (OS) and recurrencefree survival (RFS) in each subgroup. All statistical analyses were performed using SPSS 25.0 (IBM Corp., Armonk, NY). RESULTS: The effect of surgical margin width on prognosis differed based on tumor size. Among patients with tumors >3 cm, a margin ≥1 cm was associated with better OS and RFS (P<0.05) and lower rates of early recurrence. For tumors ≤3 cm, survival correlated with multiple factors-including Hepatitis B Virus Deoxyribonucleic Acid (HBV-DNA) level, serum Alpha-fetoprotein (AFP), tumor number, Tumor-Node-Metastasis (TNM) stage, tumor capsule, microvascular invasion, and vascular thrombus but not with surgical margin width. CONCLUSION: Tumor diameter influences the choice of surgical strategy for HCC. Anatomical and nonanatomical resection yielded comparable prognosis for tumors ≤3 cm. For lesions larger than 3 cm, however, wide-margin resection offered better survival than anatomical resection alone.
Postoperative pain score and infection risk in lung cancer resection: a propensity score-matching study.
Liu H, Zhang Y, Xia W … +1 more , Hu W
Am J Transl Res · 2026 · PMID 42170425 · Full text
OBJECTIVE: To explore the relationship between postoperative pain score and infection after lung cancer resection using propensity score matching. METHODS: A retrospective analysis was conducted on 206 cases of malignant...
OBJECTIVE: To explore the relationship between postoperative pain score and infection after lung cancer resection using propensity score matching. METHODS: A retrospective analysis was conducted on 206 cases of malignant lung tumors that underwent surgical resection between September 2022 and October 2025. Patients were divided into a low numerical rating scale (NRS) group (NRS ≤ 3, n = 134) and a high NRS group (NRS > 3, n = 72) based on their postoperative pain scores. A 1:1 propensity score matching was used to balance baseline characteristics, and postoperative pulmonary infection rates were compared. RESULTS: Before matching, there were no significant differences between the low and high NRS groups in terms of gender, age, history of back pain, operation time, incision intercostal width, length of hospital stay, and preoperative psychological status (all P < 0.05). After matching, there were no statistically significant differences in these indicators between the two groups (all P > 0.05). The postoperative pulmonary infection rate in patients with low NRS scores was 4.88%, lower than the 24.39% in patients with high NRS scores (P < 0.05). The visual analog scale (VAS) scores of both groups were significantly lower than those of the high NRS group at 2, 6, and 12 hours postoperatively (all P < 0.05), while the overall complication rate was significantly lower in the high-score group (P < 0.05). The forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and maximal voluntary ventilation (MVV) levels were significantly lower in the low-score group than those in the high-score group (all P < 0.05). CONCLUSION: There is a certain correlation between postoperative pain score and pulmonary infection after lung cancer resection.
Association between inflammatory cytokine gene polymorphisms and asthma susceptibility in Chinese Han children: a retrospective case-control study for potential diagnostic biomarkers.
Jiang L, Xu W, Liu X … +3 more , Xiang L, Chen Q, Zhuang C
Am J Transl Res · 2026 · PMID 42170424 · Full text
OBJECTIVES: This retrospective case-control study aimed to examine asthma prevalence and associated risk factors among the Han Chinese population, with particular emphasis on evaluating the interplay between inflammatory...
OBJECTIVES: This retrospective case-control study aimed to examine asthma prevalence and associated risk factors among the Han Chinese population, with particular emphasis on evaluating the interplay between inflammatory cytokine profiles and genetic polymorphisms in asthma pathogenesis. METHODS: Conducted at Shanghai Seventh People's Hospital, the study recruited 480 pediatric asthma patients and 840 matched controls. Comprehensive data collection included standardized clinical evaluations and epidemiological questionnaires. Laboratory analyses comprised enzyme-linked immunosorbent assay (ELISA)-based quantification of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-17 (IL-17), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping of relevant polymorphisms. RESULTS: Asthma cases demonstrated markedly increased cytokine levels versus controls (P<0.05). Significant associations were found for IL-1β -511C/T (OR=1.88, 95% CI: 1.38-2.57, P<0.05), IL-10 -1082G/A (OR=1.65, 95% CI: 1.25-2.17, P<0.05), IFN-γ +2108 A/G (OR=2.36, 95% CI: 1.18-4.73, P<0.05), and TNF-α -308 G/A (OR=1.65, 95% CI: 1.25-2.17, P<0.05). CONCLUSIONS: Cytokine gene polymorphisms in IL-1B, IFN-γ, TNF-α, and IL1B are associated with altered inflammatory profiles in asthma, suggesting a genetic contribution to disease-related immune dysregulation. The findings establish that both cytokine dysregulation and specific genetic variants contribute to asthma susceptibility in the Chinese Han population. Our study suggests that these factors hold potential as biomarkers for the diagnosis and clinical prognosis of asthma.
Nomogram-based risk stratification for postoperative dry eye in diabetic cataract patients and its application in tiered nursing care.
Li S, Yang D, Chen G … +1 more , Sun J
Am J Transl Res · 2026 · PMID 42170423 · Full text
OBJECTIVE: To identify risk factors for postoperative dry eye in diabetic cataract patients, develop a nomogram prediction model, and establish a tiered nursing intervention protocol. METHODS: A retrospective cohort stud...
OBJECTIVE: To identify risk factors for postoperative dry eye in diabetic cataract patients, develop a nomogram prediction model, and establish a tiered nursing intervention protocol. METHODS: A retrospective cohort study was conducted involving 678 diabetic patients who underwent phacoemulsification with intraocular lens implantation between January 2024 and January 2025. Patients were divided into a dry eye group (n=132) and a non-dry eye group (n=546). Least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression were used to identify independent risk factors. A nomogram was constructed, and patients were stratified into low-, moderate-, and high-risk groups based on tertile cutoffs. Model performance was validated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis. RESULTS: Postoperative dry eye occurred in 19.5% (132/678) of patients. Independent risk factors included: preoperative tear break-up time (odds ratio [OR]=0.715), Schirmer test value (OR=0.868), age ≥65 years (OR=1.975), diabetes duration ≥10 years (OR=8.511), glycated hemoglobin (HbA1c) ≥7% (OR=1.907), diabetic retinopathy (OR=0.090), glaucoma (OR=2.530), corneal comorbidities (OR=4.074), operative time ≥20 minutes (OR=2.327), and preservative-free artificial tear use (OR=0.407). The model demonstrated good discrimination (area under the curve [AUC]=0.877), calibration (Brier score = 0.1035), and clinical utility. CONCLUSION: The nomogram effectively identifies high-risk patients. Risk stratification combined with tiered nursing enables rational resource allocation and targeted intervention for diabetic cataract patients.
A case report of postpartum hemolytic uremic syndrome.
Ji S, Chen L, Liu X … +3 more , Wang H, Chen Y, Tang Y
Am J Transl Res · 2026 · PMID 42170422 · Full text
Postpartum hemolytic uremic syndrome (PHUS) is a rare thrombotic microangiopathy, and it poses significant diagnostic challenges due to its nonspecific presentation. Our department treated a patient with PHUS. Therefore,...
Postpartum hemolytic uremic syndrome (PHUS) is a rare thrombotic microangiopathy, and it poses significant diagnostic challenges due to its nonspecific presentation. Our department treated a patient with PHUS. Therefore, the aim of this article is to review and share this rare case treated in our department, providing a thorough understanding of the clinical manifestations and diagnostic criteria of PHUS which is critical for enabling timely therapeutic interventions. Informed consent was granted by the patient to share the case information.
Application of low position percutaneous puncture plus rectus abdominis anterior sheath tunnel operation for peritoneal dialysis catheterization of end-stage renal disease.
Wang H, Li J, Li J
Am J Transl Res · 2026 · PMID 42170421 · Full text
OBJECTIVES: Peritoneal dialysis (PD) is a key treatment for end-stage renal disease (ESRD), with catheter placement being crucial for success. This study evaluates the effectiveness of low-position percutaneous puncture...
OBJECTIVES: Peritoneal dialysis (PD) is a key treatment for end-stage renal disease (ESRD), with catheter placement being crucial for success. This study evaluates the effectiveness of low-position percutaneous puncture combined with the rectus abdominis anterior sheath tunnel (LPCCISTT) technique, comparing it to traditional open abdominal catheter placement (OACP). METHODS: This retrospective study included 420 ESRD patients that came from Liaocheng People's Hospital between the months of January 2020 and February 2022. Patients were divided into two groups: 180 underwent LPCCISTT and 240 received OACP. Data on operative details, recovery, complications, and survival outcome of PD catheter were analyzed. Surgical indicators included incision length, operative time, intraoperative blood loss, and complications. Recovery outcomes focused on length of hospital stay, and postoperative pain. RESULTS: The LPCCISTT group demonstrated significantly shorter incisions, reduced operative time, and less blood loss compared to the OACP group (<0.001). Postoperative recovery was faster, with shorter hospital stays (<0.001) in the LPCCISTT group. The LPCCISTT group demonstrated fewer mechanical catheter complications and infection rates (<0.001), particularly in catheter displacement, non-displacement dysfunction, PD fluid leakage (<0.032), and exit-site/tunnel infections (<0.046). Catheter survival and technical success rates were significantly higher in the LPCCISTT group ( = 0.034 and = 0.025 respectively). The obstacle-free survival (OFS) and overall survival (OS) of the catheters were both significantly prolonged (<0.001). CONCLUSION: LPCCISTT is a safer and more effective method than OACP. It has shorter operation time, faster patient recovery, fewer complications, and makes better use of hospital resources.
Risk factors and clinical strategies for lower extremity deep vein thrombosis following breast cancer surgery.
Xie Y, Deng Q, Xia X … +1 more , Li Y
Am J Transl Res · 2026 · PMID 42170420 · Full text
OBJECTIVE: To analyze the risk factors and clinical strategies for lower extremity deep vein thrombosis (LEDVT) following breast cancer (BC) surgery. METHODS: From August 2022 to August 2025, 139 BC patients who underwen...
OBJECTIVE: To analyze the risk factors and clinical strategies for lower extremity deep vein thrombosis (LEDVT) following breast cancer (BC) surgery. METHODS: From August 2022 to August 2025, 139 BC patients who underwent surgical treatment at The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital were selected for the study. Patients were grouped into the LEDVT group (n = 56) and the non-LEDVT group (n = 83) based on the presence of postoperative LEDVT. Clinical information were collected from both groups for comparative analysis, including baseline data (age, disease duration, body mass index [BMI], menopause status, concomitant hypertension, diabetes, hyperlipidemia, and smoking status), surgery-related parameters (surgery duration, surgical approach, use of adjuvant chemotherapy, diagnostic method), and pathological data (pathological stage, pathological pattern, lymphatic tumor embolus, histological grade, D-dimer [D-D], fibrinogen [FIB], thrombomodulin [TM]). Binary logistic regression analysis was performed to identify factors influencing the occurrence of LEDVT in patients after BC surgery. RESULTS: Neoadjuvant chemotherapy, lymphatic tumor thrombus, and elevated levels of D-D, FIB, and TM were closely associated with postoperative LEDVT, whereas other indicators showed no significant correlation. Multivariate analysis further confirmed that high D-D (≥ 68 ng/L), high FIB (≥ 4.84 g/L), and high TM (≥ 30.00 μg/L) were independent risk factors for LEDVT after BC surgery. A nomogram based on multivariate analysis results was constructed to identify patients at moderate-to-high risk (30-90% risk) for postoperative LEDVT. It demonstrated favorable predictive accuracy and good calibration across low- and high-risk groups. Further evaluation revealed that the area under the curve (AUC) for predicting postoperative LEDVT after BC surgery was 0.732 for D-D, 0.784 for FIB, 0.752 for TM, and 0.889 for the joint prediction of all three factors. CONCLUSION: These findings suggest that elevated levels of D-dimer (≥ 68 ng/L), FIB (≥ 4.84 g/L), and TM (≥ 30.00 μg/L) increase the risk of LEDVT following BC surgery, and the combination of these markers demonstrates superior predictive performance for LEDVT after BC surgery.
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