QUESTION: In patients undergoing invasive thoracic procedures, what are the effects of prophylactic non-invasive positive pressure ventilation (NIV)? DESIGN: Systematic review with meta-analysis of randomised trials. Met...QUESTION: In patients undergoing invasive thoracic procedures, what are the effects of prophylactic non-invasive positive pressure ventilation (NIV)? DESIGN: Systematic review with meta-analysis of randomised trials. Methodological quality was assessed using the PEDro scale and the certainty of evidence with the GRADE approach. PARTICIPANTS: Patients undergoing invasive thoracic procedures. INTERVENTION: Continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP). OUTCOME MEASURES: Length of hospital stay, postoperative pulmonary complications, need for tracheal intubation, mortality, hypoxaemia, pulmonary function and adverse events. Meta-analysis was performed for all outcomes. Subgroup analyses estimated the effects of CPAP and BIPAP independently. RESULTS: Sixteen trials with 1,814 participants were included. The average quality of the included studies was fair. Moderate certainty evidence indicated that NIV reduces postoperative pulmonary complications (RD -0.09, 95% CI -0.15 to -0.04) without increasing the rate of adverse events (RD 0.01, 95% CI -0.02 to 0.04). Low certainty evidence indicated that NIV reduces length of hospital stay (MD -1.4 days, 95% CI -2.2 to -0.5) compared with usual care. The effects on intubation and mortality rates were very close to no effect, indicating that NIV is safe. Subgroup analyses showed that the evidence for CPAP had more precise estimates that that for BiPAP. CONCLUSION: NIV reduces postoperative pulmonary complications and length of stay after invasive chest procedures without increasing the risk of adverse events. REGISTRATION: PROSPERO CRD42015019004.
QUESTION: In stroke rehabilitation, what is the effect of adding non-stimulation-based priming prior to task-specific practice on activity and motor impairment outcomes compared with task-specific practice alone? DESIGN:...QUESTION: In stroke rehabilitation, what is the effect of adding non-stimulation-based priming prior to task-specific practice on activity and motor impairment outcomes compared with task-specific practice alone? DESIGN: Systematic review with meta-analysis. PARTICIPANTS: Adult stroke survivors. INTERVENTION: The experimental groups completed a non-stimulation priming intervention prior to task-specific practice. The priming interventions were: motor imagery; action observation; combined motor imagery and action observation; mirror therapy; movement-based priming; and aerobic exercise-based priming. The control groups completed task-specific practice alone. OUTCOME MEASURES: Upper and lower limb activity and motor impairment. RESULTS: Twenty-four trials involving 803 participants were included in this systematic review. Twenty trials were included in the meta-analyses of activity outcomes and 11 trials in the meta-analyses of impairment outcomes. Four trials examined the effect of motor imagery priming prior to task-specific practice on activity outcomes (SMD 0.48, 95% CI 0.13 to 0.82). Three trials examined the effect of motor imagery priming prior to task-specific practice on motor impairment outcomes (SMD 0.51, 95% CI 0.12 to 0.89). Nine trials examined the effect of action observation priming prior to task-specific practice on activity outcomes (SMD 0.18, 95% CI -0.06 to 0.41). Two trials examined the effect of movement-based priming prior to task-specific practice on activity outcomes (SMD -0.11, 95% CI -0.64 to 0.42). Three trials examined the effect of aerobic exercise priming prior to task-specific practice on activity outcomes (SMD 0.30, 95% CI -0.19 to 0.80). The quality of the evidence was low to moderate. CONCLUSION: In stroke rehabilitation, motor imagery priming implemented prior to task-specific training has a very small to large effect on activity and motor impairment outcomes. Action observation priming implemented prior to task-specific training has a negligible to small effect on activity outcomes. Movement-based and aerobic exercise-based priming do not have any clear effect on outcomes. REGISTRATION: CRD42020093519.
QUESTION: In people with shoulder pain, what is the effect of adding mobilisation with movement (MWM) to a standard exercise program on function and pain compared with sham MWM and the same exercise program? DESIGN: A ra...QUESTION: In people with shoulder pain, what is the effect of adding mobilisation with movement (MWM) to a standard exercise program on function and pain compared with sham MWM and the same exercise program? DESIGN: A randomised trial with concealed allocation, blinded outcome assessment and intention-to-treat analysis. PARTICIPANTS: Seventy people with chronic atraumatic rotator cuff related pain, with a mean age 48 years (SD 10). INTERVENTIONS: The experimental group received MWM plus exercise and the control group received sham MWM plus exercise. Treatments were delivered twice per week for 5 weeks. OUTCOME MEASURES: The primary outcome measures were function (0 to 100 Shoulder Pain and Disability Index) and pain (0 to 10 Numerical Pain Rating Scale). Secondary outcomes were self-efficacy, perceived improvement and active pain-free range of movement. Assessment time points were at baseline (week 0), the end of the treatment period (week 5) and a follow-up 1 month after the end of treatment (week 9). RESULTS: At week 5, the experimental group improved more than the control group in function (MD -15 points, 95% CI -24 to -7), pain at night (MD -2.1, 95% CI -3.1 to -1.1), pain on movement (MD -1.5, 95% CI -2.5 to -0.6) and active range of movement in flexion (MD 16 deg, 95% CI 1 to 30), abduction (MD 23 deg, 95% CI 6 to 40), external rotation (MD 11 deg, 95% CI 4 to 17) and hand behind back (MD 20 deg, 95% CI 8 to 32). At week 9, benefits were seen in the Shoulder Pain and Disability Index (MD -9 points, 95% CI -17 to -1), pain at night (MD -1.9, 95% CI -2.9 to -0.8) and on movement (MD -1.3, 95% CI-2.3 to -0.3). The effects of the experimental intervention on other outcomes were mostly unclear due to wide confidence intervals. Blinding was successful. CONCLUSIONS: Adding MWM to exercise improved function, pain and active range of movement in people with shoulder pain. These benefits were not placebo effects. REGISTRATION: NCT04175184.
QUESTIONS: What are physiotherapy students' attitudes and beliefs towards providing care for lesbian, gay, bisexual, transgender, queer, intersex, asexual and other related identities (LGBTQIA+) individuals? What educati...QUESTIONS: What are physiotherapy students' attitudes and beliefs towards providing care for lesbian, gay, bisexual, transgender, queer, intersex, asexual and other related identities (LGBTQIA+) individuals? What education have students received on LGBTQIA+ healthcare needs? What are students' preferences for receiving this content? DESIGN: Mixed-methods design using a purpose-built online survey. PARTICIPANTS: Australian undergraduate and postgraduate physiotherapy students. METHODS: Participants were invited to complete an online survey. Data were collected on: personal, clinical, professional and educational exposure to LGBTQIA+ identities and topics; heteronormative attitudes and beliefs via the modified Heteronormative Attitudes and Beliefs Scale (mHABS); and perspectives about LGBTQIA+ care. Welch's t-test and analysis of variance were used to analyse differences in mHABS and subscale scores between groups based on personal, clinical, professional and educational exposure. Open text responses were analysed thematically. Quantitative and qualitative data were first analysed separately and then cross-validated for integration in the results. RESULTS: The survey was completed by 324 eligible students. Cross-comparison of data generated four key themes pertaining to students' perspectives about working with the LGBTQIA+ community and education about LGBTQIA+ health: students with closer personal relationships to the LGBTQIA+ community demonstrated more inclusive attitudes and beliefs about LGBTQIA+ care and education; there are cis/heteronormativity and negative views towards LGBTQIA+ health; students who are ambivalent about LGBTQIA+ care hold egalitarian beliefs; and integrated education on LGTBQIA+ health delivered by members of the community is important. CONCLUSION: Physiotherapy students' attitudes and beliefs about the LGBTQIA+ community were diverse, with cis/heteronormativity prevalent in respondents. Students with closer relationships to the LGBTQIA+ community demonstrated more inclusive attitudes and beliefs. The lack of understanding of LGBTQIA+ needs and relevance to physiotherapy highlights the need for improved LGBTQIA+ education in physiotherapy curricula.
QUESTION: Do five baseline moderators identify patients with chronic low back pain who respond best to cognitive functional therapy (CFT) when compared with usual care? DESIGN: Secondary analysis of the RESTORE randomise...QUESTION: Do five baseline moderators identify patients with chronic low back pain who respond best to cognitive functional therapy (CFT) when compared with usual care? DESIGN: Secondary analysis of the RESTORE randomised controlled trial. PARTICIPANTS: A total of 492 adults with low back pain for > 3 months with at least moderate pain-related activity limitation. INTERVENTION: Participants were allocated to CFT alone or CFT plus biofeedback; these two groups were combined for this secondary analysis. The control group was usual care. OUTCOME MEASURES: The outcome was activity limitation measured using the Roland Morris Disability Questionnaire (RMDQ) at 3, 6, 13, 26, 40 and 52 weeks. Investigated effect modifiers were baseline measures of activity limitation, cognitive flexibility, pain intensity, self-efficacy and catastrophising. RESULTS: Baseline levels of activity limitation and, potentially, cognitive flexibility were associated with different effects of CFT treatment, while pain intensity, self-efficacy and catastrophising were not. Patients who had higher baseline activity limitation had greater treatment effects at 13 and 52 weeks. A person with a baseline RMDQ score of 18 (90th percentile) would on average be 6.1 (95% CI 4.8 to 7.4) points better at 13 weeks if they received CFT compared with usual care. However, a person with a baseline score of 7 (10th percentile) would on average be 3.6 (95% CI 2.6 to 4.6) points better at 13 weeks. CONCLUSION: The finding that CFT is most effective among patients who are most disabled and incur the greatest burden strongly suggests that CFT should be considered as a treatment for this group of patients. REGISTRATION: ACTRN12618001396213.