Tobacco Induced Diseases[JOURNAL]
Sun
200 papers
Awareness of the Saudi population regarding the effects of smoking on fracture healing.
Alrabai HM, Alduraibi A, Alrabiah A … +5 more , Al Ghadir S, Alghamdi K, Alhamdi K, Bahammam A, Albishi W
Tob Induc Dis · 2025 · PMID 40861879 · Full text
INTRODUCTION: Smoking tobacco negatively affects fracture healing, increasing the risk of delayed union, malunion, and nonunion, as well as healthcare expenses. Although smoking is common in Saudi Arabia, the literature...
INTRODUCTION: Smoking tobacco negatively affects fracture healing, increasing the risk of delayed union, malunion, and nonunion, as well as healthcare expenses. Although smoking is common in Saudi Arabia, the literature on public awareness of the negative impact of smoking on fractures is limited. Our study aimed to address this gap and assess the population's knowledge on the effects of smoking on fracture healing. METHODS: An analytical cross-sectional study, involving 1033 Saudi adults, was conducted between June and September 2024 in Saudi Arabia. A validated and reliable self-created Smoking and Fracture Knowledge Assessment tool (SFKAT) was used in an online questionnaire to collect the participants' responses. Participants were categorized into good- or poor-knowledge groups based on the median SFKAT score. Binary logistic regression was used to adjust for confounding variables. RESULTS: The participants included 54.4% men. The median age of the participants was 39 years and 24.1% of them were smokers. Most smokers were men (87%). The median SFKAT score was 16 (interquartile range, IQR=12-19) and 53% of the respondents demonstrated good knowledge on the effects of smoking on fracture healing. The likelihood of good-knowledge scoring was considerably lower for men than women (adjusted odds ratio, AOR=0.48: 95% CI: 0.36-0.65; p<0.001). Healthcare workers were more likely to have a good-knowledge scoring (AOR=2.78; 95% CI: 1.90-4.08; p<0.001). Smokers had lower odds of having a good-knowledge scoring (AOR=0.54; 95% CI: 0.38-0.75; p<0.001). CONCLUSIONS: The awareness of the detrimental effects of smoking on fracture healing is suboptimal, particularly among men and smokers. Sex, healthcare work, and smoking were significantly associated with knowledge levels after adjusting for confounders. These findings may encourage educational strategies and direct counseling for populations with an observed knowledge gap to help lower the burden and treatment costs.
Usage patterns, knowledge, and attitudes of healthcare providers regarding e-cigarettes: A cross-sectional study in Saudi Arabia.
Alasmari AM, Alzahrani AA, Philip KEJ … +7 more , Alshehri Z, Alghamdi SM, Alsulayyim AS, Almaghrabi MA, Alahmadi FH, Hawsawi AM, Alasmari MM
Tob Induc Dis · 2025 · PMID 40851755 · Full text
INTRODUCTION: As electronic cigarettes (e-cigarettes) gain global popularity, healthcare providers (HCPs) play a critical role in shaping public health responses. In Saudi Arabia, little is known about HCPs' perspectives...
INTRODUCTION: As electronic cigarettes (e-cigarettes) gain global popularity, healthcare providers (HCPs) play a critical role in shaping public health responses. In Saudi Arabia, little is known about HCPs' perspectives on e-cigarettes. Hence, this study aimed to evaluate HCPs' knowledge and attitudes toward e-cigarette use and examine differences based on their personal usage patterns. METHODS: This is an observational, cross-sectional study. An online questionnaire was distributed from February to May 2024 among HCPs in Saudi Arabia. The survey, which was previously validated, collected data on sociodemographic, smoking characteristics, and 17 items designed to assess HCPs' knowledge and attitudes about e-cigarette use. RESULTS: A total of 301 HCPs participated in the study. Among the participants, 19.3% were nurses, 18.9% were PharmDs, 13.2% were dentists, 24.3% were respiratory therapists (RTs), and 24.3% were medical doctors (MDs). Approximately 64% of the respondents were male, and the median age was 32 years (IQR: 22-55). E-cigarette users comprised 22.9% of the respondents. The prevalence of e-cigarette use was highest among dentists (20.0%), with lower rates observed among respiratory therapists (11.0%), nurses (8.6%), pharmacists (7.0%), and medical doctors (6.8%). The majority of respondents (68.1%) recognized that e-cigarettes contain nicotine, 64.5% believed that e-cigarettes are addictive, and 48.9% were unsure whether e-cigarettes are FDA-approved products. Additionally, 33.3% of HCPs relied primarily on social media for information about e-cigarettes. HCPs strongly agreed [median score: 5 (IQR: 4-5)] that HCPs should be educated about e-cigarettes. HCPs who used e-cigarettes exhibited significantly more favorable attitudes toward e-cigarettes compared to non-users, based on the total score (p=0.020). CONCLUSIONS: HCPs' knowledge and attitudes regarding e-cigarettes vary widely in Saudi Arabia. Specific, targeted, and regularly updated educational initiatives are needed to ensure that healthcare professionals are confident and well informed regarding the use, risks, and guidelines related to e-cigarettes.
Association of prenatal tobacco exposure and child neurodevelopment: Analysis of the ECHO cohort study.
Zar A, Al-Amri SA, Karen AA … +6 more , Elkhalaf AS, Almalki AM, Abdulrahman AM, Al-Framarzi MH, Babu GR, Tartour AI
Tob Induc Dis · 2025 · PMID 40851754 · Full text
INTRODUCTION: We aimed to explore the association between exposure to prenatal tobacco exposure (PTE) in pregnant women and the neurodevelopment of infants and toddlers. We conducted a study using the Environmental Influ...
INTRODUCTION: We aimed to explore the association between exposure to prenatal tobacco exposure (PTE) in pregnant women and the neurodevelopment of infants and toddlers. We conducted a study using the Environmental Influences on Child Health Outcomes (ECHO)-wide cohort dataset. METHODS: We included 1970 mother-child dyads with children aged 1-42 months from the ECHO-wide cohorts. PTE was measured via self-reported active maternal smoking and secondhand smoke (SHS) exposure. Neurodevelopment was assessed using the Bayley-III, focusing on cognitive, motor, and language domains. Delay was defined as a composite score ≤85. We used Stata-18 for logistic regression to estimate the adjusted odds ratio (AOR) of the association between PTE and neurodevelopmental delay, adjusting for socioeconomic status, maternal age, and prenatal alcohol exposure. Additionally, we explored the mediation effects of birthweight. RESULTS: Active maternal smoking during pregnancy was associated with 84% higher odds of cognitive delay (AOR=1.84; 95% CI 1.25-2.7), 2-fold higher odds of language delay (AOR=2.04; 95% CI 1.49-2.8), and 16% higher odds of motor delay (OR=1.16; 95% CI 0.76-1.78) compared to children whose mothers did not smoke during pregnancy. However, adjusted models showed that SHS exposure did not affect the three domains. Additionally, mediation analysis revealed that birthweight partially mediated the negative effect of maternal smoking on cognitive function, with a natural indirect effect of -0.08 (95% CI: -0.16 - -0.01; p=0.028) and a marginal total effect of -0.81 (95% CI: -1.20 - -0.43; p=0.0001), indicating both direct and indirect pathways of influence. CONCLUSIONS: Our study supports the growing evidence linking PTE to cognitive delay. Moreover, our findings underscore the importance of optimizing prenatal smoking cessation interventions during pregnancy to mitigate the risk of neurodevelopmental delay in early childhood.
Association between maternal smoking during pregnancy and attention-deficit/hyperactivity disorder (ADHD) in children aged 4-15 years: A secondary data analysis from the NHANES dataset.
He B, Peng J, Wu M … +2 more , Deng Y, Zhang Y
Tob Induc Dis · 2025 · PMID 40785796 · Full text
INTRODUCTION: The association between maternal smoking during pregnancy (MSDP) and the risk of attention-deficit hyperactivity disorder (ADHD) in children remains inconclusive. This study aims to investigate the relation...
INTRODUCTION: The association between maternal smoking during pregnancy (MSDP) and the risk of attention-deficit hyperactivity disorder (ADHD) in children remains inconclusive. This study aims to investigate the relationship between MSDP and ADHD in children aged 4-15 years, with a particular focus on sex differences. METHODS: This secondary analysis used cross-sectional data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES), comprising 5548 US children and adolescents aged 4-15 years. Inclusion criteria comprised complete maternal smoking history during pregnancy and parent-reported ADHD diagnosis data. Multivariable logistic regression models were employed to assess the association between MSDP and ADHD, with further stratified analyses. RESULTS: Multivariable logistic regression analysis identified a significant association between MSDP exposure and elevated odds of ADHD (OR=2.11; 95% CI: 1.48-3.00). Sex-stratified analyses revealed that this association was more pronounced in female children (OR=4.18; 95% CI: 2.17-8.03) than in male children (OR=1.64; 95% CI: 1.13-2.38), the interaction between groups was significant (p for interaction <0.01). CONCLUSIONS: MSDP showed a statistically significant association with higher ADHD odds, with more pronounced estimates observed in females compared to males.
Polycyclic aromatic hydrocarbons exposure as a potential risk factor for miscarriage among women in the United States: A secondary dataset analysis of NHANES data for the period 2005-2014.
Liu X, Li Y, Chen N … +3 more , Ma J, Xing Y, Miao F
Tob Induc Dis · 2025 · PMID 40785795 · Full text
INTRODUCTION: Numerous studies have shown that polycyclic aromatic hydrocarbons (PAHs) are endocrine disruptors associated with reproduction, with tobacco smoke identified as a major non-occupational source of PAH exposu...
INTRODUCTION: Numerous studies have shown that polycyclic aromatic hydrocarbons (PAHs) are endocrine disruptors associated with reproduction, with tobacco smoke identified as a major non-occupational source of PAH exposure. However, there is still a lack of information on the relationship between PAH exposure - particularly from tobacco-related sources - and miscarriage. METHODS: The data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2014. Excluding populations with missing PAH, miscarriage, or baseline information, a total of 2573 individuals were included in this study. Logistic regression, linear regression, restricted cubic spline (RCS) analysis and subgroup analysis were used to analyze the effects of PAHs. RESULTS: Following logistic and linear regression analyses, we found that higher concentrations of 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxypyrene were associated with miscarriage (p<0.05, OR>1). Moreover, after RCS, we found a nonlinear relationship between 1-hydroxynaphthalene and miscarriage (p=0.01). The relationship between 1-hydroxynaphthalene and miscarriage could be described as an 'n-shaped' curve, with a cutoff value (4705 ng/L). At concentrations lower than the cutoff, there was a positive correlation between 1-hydroxynaphthalene and miscarriage. Conversely, at concentrations higher than the cutoff, there was a negative correlation between the two variables. Finally, a subgroup analysis was performed to explore the interaction effect of confounders with the outcome variables, to further demonstrate the robustness of the results. CONCLUSIONS: The probability of miscarriage increases with increasing concentration of certain PAHs in the body. Enhancing monitoring of tobacco-related PAHs exposure is highly important for the prevention of miscarriage.
Tobacco exposure and risk of spontaneous abortion, a dose-dependent association: A systematic review and meta-analysis.
Yuan X, Zhang F, Lv Y … +6 more , Zhao B, Zhang H, Chen L, Yan H, Hao X, Dong Z
Tob Induc Dis · 2025 · PMID 40757095 · Full text
INTRODUCTION: This systematic review and meta-analysis aimed to quantify the dose-dependent association between tobacco exposure (active and passive smoking) and the risk of spontaneous abortion (SA), incorporating subgr...
INTRODUCTION: This systematic review and meta-analysis aimed to quantify the dose-dependent association between tobacco exposure (active and passive smoking) and the risk of spontaneous abortion (SA), incorporating subgroup analyses to evaluate the influence of study design. METHODS: Following PRISMA guidelines, we conducted a systematic search of PubMed, Embase, and Cochrane Library databases for English-language observational studies published between 1991 and 2023. Studies were included if they reported on the association between active or passive tobacco exposure during pregnancy and SA risk (defined as pregnancy loss before 20 weeks of gestation). Studies involving induced abortion, ectopic pregnancy, or molar pregnancy were excluded. Eligible participants included pregnant women with documented smoking status. Methodological quality was assessed using MMAT, NOS, and GARD. Data were analyzed using fixed-effects or random-effects models, with heterogeneity assessed using I statistics. Interaction p-values were reported to evaluate heterogeneity between study designs. RESULTS: Fourteen studies (5 cohort, 7 case-control, 2 nested case-control) with a combined sample size of 741698 pregnancies met the inclusion criteria. Active smoking was significantly associated with increased SA risk (OR=1.35; 95% CI: 1.18-1.55; I=46.8%), with the highest risk observed among individuals consuming ≥20 cigarettes/day (OR=1.45; 95% CI: 1.04-2.03). Secondhand smoke exposure also elevated SA risk (OR=1.32; 95% CI: 1.14-1.55; I=37.6%). Significant heterogeneity was observed between cohort and case-control studies (interaction p=0.001). No significant interaction was found between active and passive smoking (interaction p=0.842), but a dose-dependent interaction was observed (interaction p=0.049). CONCLUSIONS: Tobacco exposure is associated with increased SA risk, particularly at higher levels. Interventions targeting heavy smokers and those exposed to secondhand smoke are needed. Limitations include imprecise smoking exposure measurement and incomplete adjustment for confounders. Future research should focus on biomarker-guided cessation strategies and explore underlying mechanisms.Systematic Review Registration: The protocol was registered in PROSPERO.ID: CRD42023406664.
Evidence synthesis of effective e-cigarette prevention messages for adolescents and young adults: A scoping review.
Chen Y, Liu H, Liu S … +5 more , Xu J, Yu X, Cai Y, Chen S, Wang Y
Tob Induc Dis · 2025 · PMID 40741485 · Full text
INTRODUCTION: This scoping review aims to examine existing evidence regarding information design for youth e-cigarette prevention, identify research gaps, and provide recommendations for future research and practice. MET...
INTRODUCTION: This scoping review aims to examine existing evidence regarding information design for youth e-cigarette prevention, identify research gaps, and provide recommendations for future research and practice. METHODS: A comprehensive literature search was conducted from the inception of databases to April 2024 across six databases: Web of Science Core Collection (including MEDLINE), PubMed, Embase, Scopus, PsycINFO, and CNKI. Peer-reviewed articles related to information design for youth e-cigarette prevention were included based on eligibility criteria. Two reviewers independently screened articles, extracted data, and synthesized results following PRISMA-ScR guidelines. RESULTS: Thirty studies met the inclusion criteria. Most studies were conducted in the United States (n=28) and employed quantitative methods (n=20). Gain-loss framing was the most commonly used theoretical framework. Three core themes in youth e-cigarette prevention information design were identified: emphasizing usage risks, optimizing presentation methods, and segmenting target audiences. Primary outcome measures included perceived message effectiveness (PME) and e-cigarette-related knowledge, beliefs, attitudes, and behavioral intentions. CONCLUSIONS: Preliminary evidence provides guidance for youth e-cigarette prevention information design. Future research should evaluate message effectiveness across diverse populations, explore message customization strategies, assess behavioral outcomes, and strengthen theoretical foundations and applications.
Vaping is associated with increased length of stay among cardiac inpatients.
Heshmati J, Mullen KA, Walker KL … +1 more , Mir H
Tob Induc Dis · 2025 · PMID 40741484 · Full text
INTRODUCTION: The rapid increase in e-cigarette use, especially among youth, raises significant health concerns. Understanding their impact on high-risk populations, such as those with cardiovascular disease, is crucial...
INTRODUCTION: The rapid increase in e-cigarette use, especially among youth, raises significant health concerns. Understanding their impact on high-risk populations, such as those with cardiovascular disease, is crucial for improving patient outcomes and reducing healthcare utilization. The aim of this study is to assess the impact of e-cigarette use on hospital length of stay (LOS) in patients with cardiovascular disease. METHODS: This cross-sectional survey was conducted at the University of Ottawa Heart Institute (November 2019-May 2020) among consecutive cardiology inpatients. Eligible participants were those admitted to the cardiac unit, fluent in French or English, and without cognitive or hearing impairments. The primary outcome is length of hospital stay. Data analysis included descriptive statistics and adjusted linear regression to explore e-cigarette use and hospital stay length, with significance set at p<0.05. RESULTS: Of 1616 cardiac patients, 1089 (73.0%) completed the survey. E-cigarette ever users were 10.4% (4.9% former, 5.5% current). Mean LOS was 11.03 days, longer for ever-users (13.1 days) than never-users (10.8 days). Ever users had a significantly longer LOS by 2.45 days (p=0.040), and current users by 3.24 days (p=0.039). CONCLUSIONS: E-cigarette use is associated with longer hospital stays among cardiac patients, even after adjusting for confounders. This underscores the potential harmful effects of vaping on cardiac recovery. Further research is needed to explore these associations and their implications for healthcare utilization.
An analysis of the global, regional, and national epidemiology and trends of Alzheimer's disease and other dementias linked to smoking from 1990 to 2021 and projections to 2050.
Xu H, Yang L, Hu S … +2 more , Xu X, Yang Y
Tob Induc Dis · 2025 · PMID 40735367 · Full text
INTRODUCTION: This research assesses the smoking-related impact on Alzheimer's disease and other dementias (ADOD), analyzing variables such as sex, age, sociodemographic index (SDI), region, and country from 1990 to 2021...
INTRODUCTION: This research assesses the smoking-related impact on Alzheimer's disease and other dementias (ADOD), analyzing variables such as sex, age, sociodemographic index (SDI), region, and country from 1990 to 2021, with forecasts to 2050. METHODS: Using data from the Global Burden of Disease Study 2021, we examined smoking-related ADOD trends from 1990 to 2021, focusing on deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) by age, sex, SDI, location, and country. We quantified trends with estimated annual percentage changes and used decomposition analysis to evaluate the effects of population growth, aging, and epidemiological shifts. A frontier analysis identified improvement areas and disparities among countries by development status. Time series prediction models were used to predict smoking-attributable ADOD trends from 2022 to 2050, considering population profiles. RESULTS: Between 1990 and 2021, there was an observable upward trend in deaths, DALYs, YLLs, and YLDs. In 2021, the burden of smoking-attributable age-related diseases predominantly impacted males across all age groups. Females, however, experienced a more pronounced reduction in age-standardized rates (ASR) of deaths, DALYs, YLLs, and YLDs compared to their male counterparts. The data from 2021 reveal that ASR of deaths, DALYs, and YLLs increased with age, reaching a peak among individuals aged ≥95 years. These ASR trends were consistent across genders, although higher rates were observed in males than in females. In 2021, the high-middle SDI region recorded the highest ASR of deaths, DALYs, YLLs, and YLDs. All five SDI regions experienced declines in ASR of deaths, DALYs, YLLs, and YLDs, with the high-SDI region demonstrating the most significant reductions in the estimated annual percentage change (EAPC). Decomposition analyses suggested that population growth was the primary factor contributing to the increase in overall deaths. CONCLUSIONS: From 1990 to 2021, there was an increase in deaths, DALYs, YLLs, and YLDs attributable to smoking-related ADOD, with projections indicating a continued rise globally until 2050. The burden of disease is mainly caused by males and middle-aged and elderly people, which should be given sufficient attention. Understanding epidemiological factors is crucial for designing effective, tailored interventions to mitigate the global burden.
Patterns of tobacco use and related factors among adolescents in South Africa: Insight from the Global Youth Tobacco Survey.
Londani M, Sewani-Rusike C, Ayo-Yusuf O … +1 more , Oladimeji O
Tob Induc Dis · 2025 · PMID 40735366 · Full text
INTRODUCTION: Adolescent multiple tobacco use is a major public health issue, both in South Africa and globally. This study sought to use latent class analysis to identify patterns of tobacco products use (combustible ci...
INTRODUCTION: Adolescent multiple tobacco use is a major public health issue, both in South Africa and globally. This study sought to use latent class analysis to identify patterns of tobacco products use (combustible cigarettes, chewing tobacco, snuff) and combustible non-cigarette tobacco products smoking (such as cigars, little cigars, pipes) and related factors among adolescents in South Africa. METHODS: Data from the Global Youth Tobacco Survey (2011) were used. A nationally representative cross-sectional school-based survey was conducted among secondary school students using a stratified two-stage cluster sampling. The sample comprised 10822 students in grades 8 to 11 in South Africa (approximately aged 13-18 years). Latent class analysis was used to identify patterns of tobacco use and examined how sociodemographic and tobacco-related characteristics are associated with such patterns. Subsequently, the multinomial logistic regression analysis was used to assess the relationship between covariates and tobacco-related variables with the probability of belonging to a specific latent class. RESULTS: The latent class analysis identified three classes: Class 1 (8.8%) was characterized by high probabilities of multiple tobacco product use; Class 2 (3.4%) had high probabilities of combustible non-cigarette tobacco products smoking; and Class 3 (83.9%) showed a minimal likelihood of current use across all four products. Compared to non-users, adolescents exposed to peer smoking had significantly higher odds of multiple product use (AOR=4.07; 95% CI: 2.93-5.66) and combustible tobacco use (AOR=6.29; 95% CI: 4.15-9.53). Parental smoking was also associated with increased odds of both multiple (AOR=2.33; 95% CI: 1.81-3.00) and combustible (AOR=1.91; 95% CI: 1.31-2.79) tobacco use. Females had lower odds than males of using multiple (AOR=0.65; 95% CI: 0.49-0.87) and combustible products (AOR=0.51; 95% CI: 0.36-0.71). Older adolescents (aged ≥18 years) were more likely to be multiple users (AOR=4.18; 95% CI: 1.59-10.98). Support for smoke-free policies was associated with reduced odds of tobacco use, while knowledge of smoking harms was associated with combustible tobacco use (AOR=1.60; 95% CI: 1.07-2.39). CONCLUSIONS: Multiple tobacco use and combustible non-cigarette tobacco products smoking is common among South African adolescents. Understanding different patterns of multiple tobacco use and combustible non-cigarette tobacco products smoking can help to inform prevention and cessation programs for adolescents. Given the risk adolescents face, tobacco cessation interventions tailored to their tobacco product of choice are urgently needed.
Global trends and cross-country inequalities in laryngeal cancer: A systematic analysis of the 2021 Global Burden of Disease study represented by China.
He Z, Hu Y, Yang X … +4 more , Han B, Li S, Huang S, Chen X
Tob Induc Dis · 2025 · PMID 40735365 · Full text
INTRODUCTION: Laryngeal cancer is one of the most common malignant tumors in the upper respiratory tract, accounting for approximately 4.5% of all malignant tumors. Smoking, drinking alcohol and occupational exposure are...
INTRODUCTION: Laryngeal cancer is one of the most common malignant tumors in the upper respiratory tract, accounting for approximately 4.5% of all malignant tumors. Smoking, drinking alcohol and occupational exposure are its main risk factors. Based on the Global Burden of Disease (GBD) database from 1990 to 2021, this study conducted a comparative analysis of laryngeal cancer-related data in China and around the world. METHODS: This is a secondary dataset analysis based on the Global Burden of Disease Study 2021. Chinese and global laryngeal cancer data for the period from 1990 to 2021 were extracted from the GBD database, and the Joinpoint regression model was used to analyze age-standardized incidence, prevalence, mortality, and DALYs. The inequality slope index (SII) and concentration index were calculated to assess health inequalities and risk factor attribution analysis was performed. Finally, a Bayesian hierarchical modeling method was used to predict the laryngeal cancer burden from 2022 to 2050. RESULTS: From 1990 to 2021, the ASPR in China increased from 7.83 per 100000 people to 9.86, while the ASIR in the world decreased from 15.27 per 100000 people to 12.56, showing an opposite trend. The global inequality index (SII) shows a downward trend but is still greater than 0 (SII was 3.70 in 2021), and the concentration index has changed from -0.23 to -0.13, indicating that health problems related to laryngeal cancer are concentrated in poor countries, but the inequality between poor and rich countries is narrowing. Among women in high-income countries, the attributed deaths caused by tobacco and alcohol consumption are 58.5% and 9.8%, respectively, which are much higher than the global average of 30.9% and 3%. The attributable proportions of DALYs caused by tobacco and alcohol consumption were 61.5% and 10.7%, respectively, which were much higher than the global average proportions of 29% and 3.1%. It is estimated that by 2050, the global incidence rate of laryngeal cancer will decrease to 2.020 per 100000 people, the mortality rate will decrease to 1.028 per 100000 people, the cancer incidence rate among Chinese men will be 0.453 per 100000 people, and the ASMR will decrease to 0.173 per 100000 people. CONCLUSIONS: The global burden of laryngeal cancer decreased overall from 1990 to 2021, but the incidence and prevalence in China are complex and may be influenced by urbanization and lifestyle changes. The incidence of laryngeal cancer in Chinese women continues to rise, which is worthy of attention. Low-income countries face greater challenges, where digital health technologies can help with early screening and treatment.
Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach.
Lin B, Ma H, Lin Y … +4 more , Lin T, Han X, Lin M, Gao H
Tob Induc Dis · 2025 · PMID 40735364 · Full text
INTRODUCTION: Viral hepatitis, caused by various hepatitis viruses, is a global health threat leading to chronic liver disease, hepatic cirrhosis, hepatic failure, and hepatocellular carcinoma. Smoking, a known risk fact...
INTRODUCTION: Viral hepatitis, caused by various hepatitis viruses, is a global health threat leading to chronic liver disease, hepatic cirrhosis, hepatic failure, and hepatocellular carcinoma. Smoking, a known risk factor for numerous chronic diseases, has been implicated in the pathogenesis of viral hepatitis. However, understanding the relationship between smoking and viral hepatitis is complex due to the presence of confounding factors and the potential for reverse associations. METHODS: We utilized Mendelian randomization (MR) analysis to explore the potential association between smoking behavior and viral hepatitis. In this study, SNPs were utilized as instrumental variables in a Mendelian randomization framework to examine the relationship between smoking behavior and viral hepatitis risk. To ensure the accuracy of the experiment, our data were sourced from large-scale genome-wide association studies (GWAS) and analyzed using a series of methods, such as inverse variance weighting (IVW) and leave-one-out analysis. RESULTS: The MR analysis revealed significant positive associations between SNPs related to smoking initiation, status, and cessation, and the risk of viral hepatitis. The IVW method demonstrated a consistent rightward shift of the effect estimates, indicating a potential increase in viral hepatitis risk associated with smoking exposure. Smoking initiation, status, and cessation were associated with increased odds of viral hepatitis by 2.17-fold (95% CI: 1.45-3.24, p=0.00015), 2.93-fold (95% CI: 1.58-5.41, p=0.00061), and 5.30-fold (95% CI: 2.05-13.70, p=0.00057), respectively. The leave-one-out analysis further validated the robustness of our model, with minor SNP-specific deviations observed. CONCLUSIONS: Our study presents strong associations between smoking behavior and an elevated risk of viral hepatitis, highlighting the need for further investigation into this potential connection. These findings underscore the importance of smoking cessation in liver disease management and inform public health strategies aimed at reducing the burden of viral hepatitis.
Deciphering gene-smoking interactions in age-related macular degeneration through cross-biobank genomic integration.
Guo J, Jiang Y, Xu X … +6 more , Wang J, Yao X, Wang X, Yang H, Li MJ, Yan H
Tob Induc Dis · 2025 · PMID 40735363 · Full text
INTRODUCTION: This study aims to identify genetic loci associated with age-related macular degeneration (AMD) and assess the interaction between genetic susceptibility and smoking history. METHODS: A meta-analysis of dis...
INTRODUCTION: This study aims to identify genetic loci associated with age-related macular degeneration (AMD) and assess the interaction between genetic susceptibility and smoking history. METHODS: A meta-analysis of discovery genome-wide association studies (GWASs), involving a total of 42542 AMD patients and 920322 controls from four large-scale European cohorts, was conducted using METAL, a software tool commonly used for meta-analysis of GWAS. A polygenic risk score (PRS) was derived from the meta-analysis results for 331281 UK Biobank participants. Cox proportional hazards models evaluated interactions between genetic predisposition and smoking history at both PRS and variant levels. Logistic regression models examined plasma complement protein profiles across AMD PRS and smoking status groups. RESULTS: We identified two novel risk loci, OCA2 melanosomal transmembrane protein (OCA2) and nitric oxide associated 1 (NOA1). Incorporating the PRS significantly enhanced AMD risk prediction in 331281 UK Biobank participants, with the area under the curve (AUC) increasing from 0.74 to 0.76 (p=2×10). During a mean follow-up of 13.6 years, Cox models revealed significant additive (relative excess risk due to interaction, RERI=0.13; 95% CI: 0.06-0.19; attributable proportion, AP=0.08; 95% CI: 0.04-0.13; synergy index, SI=1.33; 95% CI: 1.13-1.56) and multiplicative interactions (hazard ratio, HR=1.08; 95% CI: 1.03-1.14, p=2.65×10) between PRS and smoking history. Variant-level interactions were prominent at complement factor H (CFH) and complement factor I (CFI) loci. Individuals who have ever smoked and high PRS exhibited dysregulated plasma proteins in the alternative, classical and lectin complement pathways. CONCLUSIONS: This study revealed the genetic architecture of AMD and highlighted the synergistic effects of smoking and genetic risk, emphasizing the potential need to integrate genetic assessments into prevention strategies.
Tobacco smoking as an endocrine disrupting chemical: An assessment through biological monitoring.
Lee HS, Na HK, Chang SS … +4 more , Kim SY, Kim CS, Kim MJ, Yang M
Tob Induc Dis · 2025 · PMID 40735362 · Full text
INTRODUCTION: Tobacco smoke is a mixture of endocrine disrupting chemicals (EDCs), which may accelerate biological ageing. METHODS: Within this cross-sectional study we recruited adult and adolescent subjects (2013-2014)...
INTRODUCTION: Tobacco smoke is a mixture of endocrine disrupting chemicals (EDCs), which may accelerate biological ageing. METHODS: Within this cross-sectional study we recruited adult and adolescent subjects (2013-2014) and performed biological monitoring to clarify health end points of tobacco smoking between adolescents and adults (n=620) with exposure biomarkers, i.e. CO, urinary cotinine, t,t-muconic acid (TTMA), malondialdehyde (MDA), and obtained information of behavioral factors and tobacco addiction status in South Korea. We also analyzed the 96 SNPs for metabolism, addiction, and expression differences and compared mtDNA abnormalities in buccal and blood cells. RESULTS: There was an association between tobacco smoking and oxidative stress with urinary cotinine and MDA levels. Youth smokers showed lower frequency in some of mtDNA alteration, SNPs for consistent bases between buccal and blood cells, than youth non-smokers or adult smokers. Among the SNPs, the polymorphisms on SULT1A1, DRD2, and ADH1B were related to multiple of the above exposure biomarkers. Interestingly, urinary MDA or TTMA in youth were similar to those in adults (MDA, 2.7 ± 1.5 vs 2.4 ± 1.3 μM; TTMA, 74.1 ± 129.9 vs 98.8 ± 126.1 μg/L), although urinary cotinine levels were approximately four-fold lower in youth than adults (0.1 ± 0.4 vs 0.6 ± 0.9 mg/L; p<0.0001). Urinary MDA, an oxidative stress biomarker, were negatively associated with the growth rate among the adolescents. CONCLUSIONS: The present biological monitoring study assessed the impact of combustible cigarette smoking with various exposure, susceptibility and response biomarkers to clarify how tobacco smoking differently affects adolescents and adults in South Korea.
Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES.
Wei K, Chen X
Tob Induc Dis · 2025 · PMID 40718136 · Full text
INTRODUCTION: α-Klotho is a circulating protein linked to longevity and healthy aging. While tobacco use is known to reduce α-Klotho levels, the effects of marijuana use on this aging-related biomarker remain unclear. Th...
INTRODUCTION: α-Klotho is a circulating protein linked to longevity and healthy aging. While tobacco use is known to reduce α-Klotho levels, the effects of marijuana use on this aging-related biomarker remain unclear. This study aimed to examine the association between marijuana use and serum α-Klotho levels in a nationally representative sample of US adults. METHODS: We conducted a secondary analysis of publicly available data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016, including 6601 adults aged 40-59 years with available serum α-Klotho levels and complete substance use data. Multivariable linear regression models were used to estimate the association between marijuana use and α-Klotho levels. RESULTS: Current marijuana use was significantly associated with lower serum α-Klotho levels compared to never use (β= -0.084; 95% CI: -0.126 - -0.041), independent of tobacco and illicit drug use. In the combined exposure model, those using both marijuana and tobacco exhibited the greatest reduction in α-Klotho (β= -0.112; 95% CI: -0.162 - -0.062). The inverse association persisted across most subgroups, including both current smokers (β= -0.078; 95% CI: -0.134 - -0.021) and non-smokers (β= -0.087; 95% CI: -0.151 - -0.002). CONCLUSIONS: Marijuana use was independently associated with lower circulating α-Klotho levels, suggesting a potential link between cannabis exposure and accelerated biological aging, even after adjusting for tobacco use. These findings highlight the need for further longitudinal studies to investigate the long-term impact of marijuana and tobacco use on systemic aging processes and health effects.
Knowledge and perceptions of nicotine, smoking cessation and electronic nicotine delivery systems among physicians and pharmacists in a Swiss hospital group.
Christen SE, Scanniello E, Hammann F … +4 more , Meyer-Massetti C, Auer R, Etter JF, Liakoni E
Tob Induc Dis · 2025 · PMID 40709317 · Full text
INTRODUCTION: Despite the important role that healthcare professionals play in smoking cessation strategies, recent reports from several countries show misperceptions about nicotine, pharmacotherapy for smoking cessation...
INTRODUCTION: Despite the important role that healthcare professionals play in smoking cessation strategies, recent reports from several countries show misperceptions about nicotine, pharmacotherapy for smoking cessation and novel nicotine products, but little is known about such knowledge gaps among healthcare professionals in Switzerland. METHODS: This study involved a cross-sectional anonymous survey. Physicians and pharmacists from a large hospital group in Switzerland were invited in 2023 by e-mail to participate. The survey covered nicotine, smoking cessation, and knowledge of electronic nicotine delivery systems (ENDS). RESULTS: Of the 2035 healthcare professionals contacted, 279 responded to the survey (14%). Fifty-three percent of participants identified as women, 69% were in the age group of ≤40 years, 77% were never smokers, and 85% saw patients daily. The majority (76%) agreed that nicotine is the main substance in tobacco responsible for addiction, while 73% and 69% disagreed that nicotine on its own causes cancer or chronic obstructive pulmonary disease (COPD), respectively. Most participants (n=128; 63%) opposed the recommendation of e-cigarettes as a smoking cessation aid, although e-cigarettes were considered less harmful than combustible cigarettes, both for users and bystanders. Nevertheless, 64% considered them to be equally or more problematic for public health than tobacco cigarettes. CONCLUSIONS: This survey highlights knowledge gaps and misperceptions about nicotine and smoking cessation products among healthcare professionals in a large hospital group in Switzerland. Respondents appeared to have a relative accurate understanding regarding most of the direct effects of nicotine. However, uncertainties were noted in relation to newer products such as e-cigarettes. Future research should extend to other healthcare professionals and assess the impact of targeted training on knowledge and clinical practice.
Alcohol dependence trajectories and smoking cessation among Korean men who smoke: A secondary data analysis from the Korean longitudinal study of aging dataset.
Han M, Kang H, Chun HR … +1 more , Cho SI
Tob Induc Dis · 2025 · PMID 40704130 · Full text
INTRODUCTION: Alcohol dependence may hinder smoking cessation, yet few studies have examined how long-term patterns of alcohol use influence quit outcomes. This study assessed how alcohol dependence trajectories affect s...
INTRODUCTION: Alcohol dependence may hinder smoking cessation, yet few studies have examined how long-term patterns of alcohol use influence quit outcomes. This study assessed how alcohol dependence trajectories affect smoking cessation among Korean men who smoke. METHODS: We performed a secondary analysis using waves 1-7 (2006-2018) of the Korean Longitudinal Study of Aging (KLoSA). Latent class growth analysis (LCGA) identified alcohol dependence trajectories among 2356 men aged ≥45 years who participated in at least three consecutive waves. Multinomial logistic regression (n=1959) was used to assess predictors of trajectory class membership, and Cox proportional hazards models (n=1122) were used to evaluate the association between class membership and smoking cessation. Statistical significance was set at a two-sided p<0.05. RESULTS: Three alcohol dependence trajectories were identified: stable low (80.7%), decreasing (14.3%), and increasing (5.0%). Participants in the decreasing (adjusted hazard ratio, AHR=0.77; 95% CI: 0.63-0.95) and increasing (AHR=0.60; 95% CI: 0.42-0.86) groups were less likely to quit smoking than the stable low group. Multinomial regression showed that, compared to non-smokers, both former smokers (AOR=1.83; 95% CI: 1.24-2.70) and current smokers (AOR=2.23; 95% CI: 1.60-3.09) were associated with higher odds of belonging to the decreasing trajectory. Only current smoking was significantly associated with the increasing trajectory (AOR=2.28; 95% CI: 1.36-3.84). In stratified analyses, the inverse association between increasing trajectory and quitting was significant only in those aged 45-54 years. Sensitivity analyses using weighted and complete-case data confirmed the robustness of the findings. CONCLUSIONS: Alcohol dependence trajectories were significantly associated with smoking cessation outcomes, especially among younger individuals. Smoking status was also a significant predictor of trajectory class membership, with current smokers more likely to belong to the increasing trajectory. Integrated interventions addressing both behaviors may improve cessation outcomes in high-risk groups.
Tobacco smoking in a high-IQ society in Indonesia.
Putra TMH, Siburian R, Mukmina S … +4 more , Wardhani N, Alam FE, Wattanasiriporn W, Munirwan H
Tob Induc Dis · 2025 · PMID 40704129 · Full text
INTRODUCTION: Individuals with higher intelligence are often believed to be more aware of the health risks associated with smoking and more inclined to adopt healthier lifestyles. This study investigates the prevalence o...
INTRODUCTION: Individuals with higher intelligence are often believed to be more aware of the health risks associated with smoking and more inclined to adopt healthier lifestyles. This study investigates the prevalence of smoking among high-IQ individuals in Indonesia, providing insights that could inform targeted health interventions. METHODS: This is a cross-sectional study conducted in a population with high IQ. An online-based survey form was distributed to all active members of the Mensa high-IQ society in Indonesia over a three-month period (October to December 2024). The survey form collected sociodemographic data and queried participants about their smoking status and related details. The primary outcome of interest was the smoking habits of the subjects. RESULTS: A total of 102 respondents aged ≥18 years participated in the study, which involved 73 men (71.6%) and 29 women (28.4%), with a mean age of 33.8 ± 10.2 years. The overall smoking prevalence among high-IQ individuals in Indonesia was 10.8%, with 12.3% of men and 6.9% of women currently smoking. Additionally, 9.8% were former smokers, leading to a total current or past smoking rate of 20.6%. This number is dramatically lower than the national smoking prevalence, which currently stands at around 40.3%. Although various sociodemographic factors were assessed, none showed a statistically significant association with smoking status in this population. CONCLUSIONS: The prevalence of tobacco smoking among high-IQ individuals in Indonesia is 10.8% which is significantly lower than the national average. Although no statistically significant associations were found between sociodemographic variables and smoking status, smokers tended to have a family member who smoked, and individuals with higher annual incomes were less likely to smoke.
Childhood cigarette smoking is associated with health-related quality of life in older US adults.
Ozga JE, Sargent JD, Steinberg AW … +3 more , Tang Z, Stanton CA, Paulin LM
Tob Induc Dis · 2025 · PMID 40704128 · Full text
INTRODUCTION: Childhood smoking onset is associated with chronic obstructive pulmonary disease (COPD), independent of current smoking and smoking history. Its association with lower quality of life has not been tested. W...
INTRODUCTION: Childhood smoking onset is associated with chronic obstructive pulmonary disease (COPD), independent of current smoking and smoking history. Its association with lower quality of life has not been tested. We examined the association between childhood smoking and measures of global health among older US adults. METHODS: This study involved a cross-sectional survey of US adults ≥40 years (n=7056) from Wave 5 (2019) of the Population Assessment of Tobacco and Health Study. Ever smokers were asked when they began smoking regularly. Weighted multivariable analysis assessed onset of regular smoking at age of <15 years as a risk factor for lower Patient-Reported Outcomes Measurement Information System Global Physical and Mental Health (GPH and GMH) scores, adjusting for current smoking, smoking intensity, cigarette pack-years, secondhand smoke exposure, and other covariates. Sensitivity analysis added smoking-related disease comorbidities (e.g. COPD). RESULTS: Sociodemographics were reflective of the US population aged ≥40 years, with 6.8% reporting childhood smoking and 16.9% current smoking. Mean (SD) for GPH and GMH were 14.8 (3.1) and 14.5 (3.8), respectively. In the multivariable analysis, compared to onset smoking at an older childhood age, GPH and GMH were significantly lower for those with early onset of smoking (-4.27%; 95% CI: -6.52 - -1.97 and -3.34%; 95% CI: -6.08 - -0.52; respectively). Global health was also negatively associated with current smoking, higher pack-years, and secondhand smoke exposure. The association between childhood smoking and GPH (but not GMH) remained significant after further adjustment for disease mediators. CONCLUSIONS: Childhood smoking was independently associated with lower quality of life among adults aged ≥40 years. Adverse effects of smoking on development during adolescence may have implications that extend beyond associations with chronic disease.
Conflicts of interest and the role of governments in tobacco control.
Bover PC, Huber L, Salgado L … +1 more , Bostic C
Tob Induc Dis · 2025 · PMID 40704127 · Full text
Abstract loading — click title to view on PubMed.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe