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Disease Markers[JOURNAL]

Sun 200 papers
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Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway.

Lu Y, Zhang Y, Wang X … +11 more , Zhang H, Zhu Y, Zhang J, Sha H, Zou R, Gan Y, Sui Y, Wang J, Du T, Wu J, Feng J

Dis Markers · 2023 · PMID 37457886 · Full text

Colorectal cancer (CRC) is a serious threat to human health, and its underlying mechanisms remain to be further explored. Aldolase A (ALDOA) has received increasing attention for its reported association with multiple ca... Colorectal cancer (CRC) is a serious threat to human health, and its underlying mechanisms remain to be further explored. Aldolase A (ALDOA) has received increasing attention for its reported association with multiple cancers, but the role and mechanisms of ALDOA in CRC are still unclear. In the current study, high expression levels and enzymatic activity of ALDOA were detected in CRC tissues and cell lines, indicating the clinical significance of ALDOA in human CRC. In addition, silencing ALDOA significantly impaired the proliferation and metastasis of CRC cells and . Mechanistically, immunoprecipitation assays and mass spectrometry analysis identified the binding protein COPS6 of ALDOA. Furthermore, the promoting effects of upregulated ALDOA on CRC cell proliferation and metastasis were inhibited by COPS6 depletion, demonstrating COPS6 was required for ALDOA in mediating CRC progress. Moreover, the epithelial-mesenchymal transition (EMT) program and MAPK signaling pathway were found to be activated by ALDOA overexpression as well. In summary, our findings suggested that ALDOA facilitated the proliferation and metastasis of CRC by binding and regulating COPS6, inducing EMT, and activating the mitogen-activated protein kinase (MAPK) signaling pathway. The present study provided evidence for ALDOA as a promising potential biomarker for CRC.

Retracted: The Perspectives of Surrogates and Healthcare Providers Regarding SDM (Shared Decision-Making).

Markers D

Dis Markers · 2023 · PMID 37387775 · Full text

[This retracts the article DOI: 10.1155/2023/6251492.]. [This retracts the article DOI: 10.1155/2023/6251492.].

Retracted: Changes in T-Cell Subsets and Serum IFN-, IL-17, and IgE Levels in Children with Respiratory Syncytial Virus Capillary Bronchitis and Their Clinical Significance.

Markers D

Dis Markers · 2023 · PMID 37387774 · Full text

[This retracts the article DOI: 10.1155/2022/2549845.]. [This retracts the article DOI: 10.1155/2022/2549845.].

Retracted: Probiotic Supplement Preparation Relieves Test Anxiety by Regulating Intestinal Microbiota in College Students.

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Dis Markers · 2023 · PMID 37387773 · Full text

[This retracts the article DOI: 10.1155/2021/5597401.]. [This retracts the article DOI: 10.1155/2021/5597401.].

Retracted: Efficacy of Laparoscopic Totally Extraperitoneal Repair for Inguinal Hernia.

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Dis Markers · 2023 · PMID 37387772 · Full text

[This retracts the article DOI: 10.1155/2022/2970257.]. [This retracts the article DOI: 10.1155/2022/2970257.].

Retracted: Senkyunolide H Affects Cerebral Ischemic Injury through Regulation on Autophagy of Neuronal Cells Via P13K/AKT/mTOR Signaling Pathway.

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Dis Markers · 2023 · PMID 37387771 · Full text

[This retracts the article DOI: 10.1155/2022/9211621.]. [This retracts the article DOI: 10.1155/2022/9211621.].

Retracted: To Explore the Diagnostic Value of Bulbocavernosus Muscle Reflex and Pudendal Somatosensory Evoked Potentials for Diabetic Neurogenic Bladder.

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Dis Markers · 2023 · PMID 37387770 · Full text

[This retracts the article DOI: 10.1155/2022/6096326.]. [This retracts the article DOI: 10.1155/2022/6096326.].

Retracted: A Meta-analysis: Cost Comparison of Flow Diversion and Coil Embolization for Intracranial Aneurysm.

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Dis Markers · 2023 · PMID 37387769 · Full text

[This retracts the article DOI: 10.1155/2022/2925366.]. [This retracts the article DOI: 10.1155/2022/2925366.].

Retracted: Multiomics Immune-Related lncRNA Analysis of Oral Squamous Cell Carcinoma and Its Correlation with Prognosis.

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Dis Markers · 2023 · PMID 37387768 · Full text

[This retracts the article DOI: 10.1155/2022/6106503.]. [This retracts the article DOI: 10.1155/2022/6106503.].

Retracted: Exogenous Hydrogen Sulfide Mitigates Oxidative Stress and Mitochondrial Damages Induced by Polystyrene Microplastics in Osteoblastic Cells of Mice.

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Dis Markers · 2023 · PMID 37387767 · Full text

[This retracts the article DOI: 10.1155/2023/2516472.]. [This retracts the article DOI: 10.1155/2023/2516472.].

Retracted: Sappanone A Alleviated IL-1-Induced Inflammation in OA Chondrocytes through Modulating the NF-B and Nrf2/HO-1 Pathways.

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Dis Markers · 2023 · PMID 37387766 · Full text

[This retracts the article DOI: 10.1155/2022/2380879.]. [This retracts the article DOI: 10.1155/2022/2380879.].

Retracted: Development and Validation of Diagnostic Models for Hand-Foot-and-Mouth Disease in Children.

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Dis Markers · 2023 · PMID 37387765 · Full text

[This retracts the article DOI: 10.1155/2021/1923636.]. [This retracts the article DOI: 10.1155/2021/1923636.].

Retracted: Effect of Targeted Care plus Exercise Intervention on Blood Glucose Levels and Maternal and Newborn Outcomes in Patients with Gestational Diabetes Mellitus.

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Dis Markers · 2023 · PMID 37387764 · Full text

[This retracts the article DOI: 10.1155/2022/7584936.]. [This retracts the article DOI: 10.1155/2022/7584936.].

Retracted: Clinical Application of Anlotinib Combined with Docetaxel: Safe and Effective Treatment for Lung Carcinoma.

Markers D

Dis Markers · 2023 · PMID 37387763 · Full text

[This retracts the article DOI: 10.1155/2022/2483816.]. [This retracts the article DOI: 10.1155/2022/2483816.].

Retracted: Circular RNA circFAT1(e2) Facilitates Cell Progression through the miR-30e-5P/MYBL2 Pathway in Glioma.

Markers D

Dis Markers · 2023 · PMID 37387762 · Full text

[This retracts the article DOI: 10.1155/2023/7418365.]. [This retracts the article DOI: 10.1155/2023/7418365.].

Retracted: Correlation between Glycated Haemoglobin Level, Cardiac Function, and Prognosis in Patients with Diabetes Mellitus Combined with Myocardial Infarction.

Markers D

Dis Markers · 2023 · PMID 37387761 · Full text

[This retracts the article DOI: 10.1155/2022/2191294.]. [This retracts the article DOI: 10.1155/2022/2191294.].

Retracted: The Value of MRI Combined with AFP, AFP-L3, GP73, and DCP in the Diagnosis of Early Primary Liver Cancer.

Markers D

Dis Markers · 2023 · PMID 37387760 · Full text

[This retracts the article DOI: 10.1155/2022/8640999.]. [This retracts the article DOI: 10.1155/2022/8640999.].

Retracted: Application of Preoperative Adductor Canal Block Coupled with General Anaesthesia in Elderly Patients Undergoing Total Knee Arthroplasty.

Markers D

Dis Markers · 2023 · PMID 37387759 · Full text

[This retracts the article DOI: 10.1155/2022/3071665.]. [This retracts the article DOI: 10.1155/2022/3071665.].

Retracted: To Explore and Analyze the Safety and Clinical Efficacy of Periocline-Assisted Periodontal Basic Therapy on Chronic Periodontitis.

Markers D

Dis Markers · 2023 · PMID 37387758 · Full text

[This retracts the article DOI: 10.1155/2022/4601259.]. [This retracts the article DOI: 10.1155/2022/4601259.].

Retracted: The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation.

Markers D

Dis Markers · 2023 · PMID 37387757 · Full text

[This retracts the article DOI: 10.1155/2022/1111438.]. [This retracts the article DOI: 10.1155/2022/1111438.].
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