Lianou AD, Dragioti E, Mantzoukas S
… +1 more, Gouva M
Maedica (Bucur)
· 2024 Dec · PMID 39974456
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Rhinoplasty, one of the most prevalent facial plastic surgeries, bears both functional and aesthetic import. This literature review examined the psychosomatic dimensions of rhinoplasty and their influence on patients' qu...Rhinoplasty, one of the most prevalent facial plastic surgeries, bears both functional and aesthetic import. This literature review examined the psychosomatic dimensions of rhinoplasty and their influence on patients' quality of life and self-care. Rhinoplasty, whether undertaken alone or in conjunction with septoplasty, is intricate and technically demanding, with success being largely contingent upon psychosomatic factors. The popularity of rhinoplasty has burgeoned due to augmented social acceptance and media exposure. Postoperative psychological outcomes vary, with dissatisfaction being frequently linked to pre-existing psychopathology. Men often exhibit higher levels of psychopathology and are less satisfied after surgery comparatively to women. Prudent patient selection, realistic expectations and psychological screening are imperative for successful outcomes. Rhinoplasty affects individuals of all ages, from adolescents to the elderly, with involving unique concerns and benefits. Patient satisfaction hinges on factors such as gender, age, education, culture, ethnicity, occupation, economic profile, psychological profile and expectations. The use of patient reported outcome measures (PROMs) is indispensable for evaluating the health-related quality of life and psychosocial changes following rhinoplasty. Comprehending these dimensions is crucial for enhancing patient satisfaction and ensuring successful outcomes.
Lianos GD, Kyrochristou GD, Lianou AD
… +4 more, Tatsis V, Schizas D, Vlachos K, Mitsis M
Maedica (Bucur)
· 2024 Dec · PMID 39974454
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As gastric cancer represents the fifth most common cancer diagnosis and the third leading cause of cancer death worldwide, it remains a current social and health issue. A variety of genetic, epigenetic and environmental...As gastric cancer represents the fifth most common cancer diagnosis and the third leading cause of cancer death worldwide, it remains a current social and health issue. A variety of genetic, epigenetic and environmental factors contribute to the development of gastric cancer, although the etiology remains unclear. Timely diagnosis and appropriate treatment play the most crucial role not only in the containment of morbidity and mortality but also in the prognosis. The establishment of novel non-invasive biomarkers into patient management protocols represents a very promising and challenging approach. In this article, we focus on gastric cancer biomarkers with a special interest in gastric juice that may represent a novel, non-invasive, cost-effective 'liquid biopsy'.
Bahrami SARS, Alshargabi B, Monajem MM
… +2 more, Jiryaei N, Karkhanei B
Maedica (Bucur)
· 2024 Dec · PMID 39974453
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BACKGROUND: COVID-19, in addition to affecting the respiratory system, exerts an impact on various extrapulmonary organs, including the cardiovascular system. This influence may lead to hospitalization in the intensive c...BACKGROUND: COVID-19, in addition to affecting the respiratory system, exerts an impact on various extrapulmonary organs, including the cardiovascular system. This influence may lead to hospitalization in the intensive care unit (ICU) and even mortality. This study aimed to investigate the relationship of right and left bundle branch blocks (RBBB and LBBB) to mortality in COVID-19 patients admitted to the ICU. METHODS: This descriptive-analytical retrospective study examined 650 COVID-19 patients hospitalized in the ICU of Sina Hospital in Hamadan, Iran, during the fifth peak of the pandemic. Patients were initially categorized into two groups. Data were collected using a researcher-designed checklist that included demographic and clinical information, such as age, gender, smoking history, underlying medical conditions, initial electrocardiogram findings on admission (specifically the presence of RBBB or LBBB) and final outcomes (survival or mortality). Data analysis was conducted using SPSS software, at a significance level of 0.05. RESULTS: Among the 650 COVID-19 patients with a mean age of 60.55 ± 17.22 years, 24 subjects had RBBB and 20, LBBB. Among the 161 subjects who did not survive, 11 (6.8%) had RBBB and six (3.7%) LBBB. A significant association between RBBB and mortality in COVID-19 patients was found (P=0.049). Right bundle branch blocks were also significantly associated with underlying medical conditions (P=0.034) and smoking history (P=0.031). CONCLUSION: Electrocardiography (ECG) is a valuable tool in predicting the severity of COVID-19 and patient mortality. The presence of RBBB is associated with higher mortality rates in COVID-19 patients. Therefore, ECG can serve as a valuable diagnostic tool both upon admission and during hospitalization.
Maedica (Bucur)
· 2024 Dec · PMID 39974452
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Indocyanine green (ICG) has emerged as a transformative tool for intraoperative imaging in the field of oncology, significantly improving the identification and localization of tumors, lymphatic structures and metastatic...Indocyanine green (ICG) has emerged as a transformative tool for intraoperative imaging in the field of oncology, significantly improving the identification and localization of tumors, lymphatic structures and metastatic lesions. This narrative review aims to synthesize findings from a comprehensive range of studies that evaluate the efficacy, applications and limitations of ICG fluorescence-guided surgery across various surgical specialties, including colorectal, gynecologic and hepatobiliary oncology. We meticulously analyzed studies published from 2010 to the present, highlighting the technical aspects of ICG administration and imaging techniques as well as the quantitative metrics of success, such as detection rates and negative surgical margins. The review identifies a trend toward increasing use of ICG due to its ability to provide real-time feedback during surgery, thus facilitating more precise and minimally invasive procedures. Moreover, this review explores recent advancements in ICG applications, including multimodal imaging techniques that combine fluorescence with other imaging modalities, such as near-infrared imaging and preoperative imaging studies. These innovations hold promise for further enhancing surgical precision, improving patient outcomes and optimizing intraoperative decision-making. Limitations associated with ICG use, such as variability in fluorescence intensity among different tumor types and the challenge of quantifying the optimal dosage, are also discussed. In conclusion, this narrative review underscores the critical role of ICG fluorescence in modern surgical oncology and provides insights into future research directions aimed at refining its use and expanding its applicability. Potential avenues for investigation include standardized protocols for ICG administration, investigation of patient selection criteria and comprehensive evaluations of long-term outcomes associated with ICG-guided surgical procedures.
Giotis D, Konstantinidis C, Plakoutsis S
… +7 more, Kotsias C, Galanis C, Konstantinou A, Anagnostou E, Tsiampas D, Vardakas D, Panagiotopoulos V
Maedica (Bucur)
· 2024 Dec · PMID 39974451
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The aim of this study is to present a case of giant cell tumor of the tendon sheath in the anatomical snuffbox, an extremely unusual location of such neoplasms. A 54-year-old male came to our hospital with a mass in his...The aim of this study is to present a case of giant cell tumor of the tendon sheath in the anatomical snuffbox, an extremely unusual location of such neoplasms. A 54-year-old male came to our hospital with a mass in his left hand that had appeared over the past two years, demonstrating a recent rapid increase in size. The physical examination revealed that the mass did not cause any pain or restriction in the range of motion. The neurovascular function remained intact. The magnetic resonance imaging (MRI) detected a 2.5 x 1.5 cm mass in the anatomical snuffbox but without a clear diagnosis. A meticulous marginal surgical excision was performed and biopsy sample was sent for histopathologic examination. Intraoperatively, it was observed that the tumor extended in-between the tendons of the first and third dorsal compartments, reaching the radial artery at the depth of the anatomical snuffbox. Macroscopically, the tumor resembled a giant cell tumor, which was confirmed by histological examination. The patient was discharged from the hospital on the same day. He fully resumed his daily activities three weeks after surgery. Three years later, he remained free of symptoms without any recurrence of the tumor. Giant cell tumor of the tendon sheath is a benign neoplasm that demonstrates local aggressiveness. In several cases, nerves and blood vessels might be entrapped within the tumor. This complication along with its high recurrence rate renders surgical excision of the tumor a particularly demanding procedure.
Shahraki Z, Zarrinnia A, Askari F
… +2 more, Rastkar M, Ghajarzadeh M
Maedica (Bucur)
· 2024 Dec · PMID 39974450
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OBJECTIVE: To estimate the pooled prevalence of pregnancy-related issues in women who were exposed to Ocrelizumab before or during pregnancy. METHODS: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, references an...OBJECTIVE: To estimate the pooled prevalence of pregnancy-related issues in women who were exposed to Ocrelizumab before or during pregnancy. METHODS: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, references and conference abstracts were comprehensively searched by two independent researchers. The search was conducted on 1 June 2023. RESULTS: A literature search revealed 320 records, of which 44 full-texts were evaluated and only five studies remained for the systematic review, among which one study was conducted in Australia, one in the United States, one in Canada and one in the United Kingdom. All eligible studies were conducted between 2017 and 2022. They included a number of patients ranging from 12 to 608, and totalized 1 305 participants and 1 306 pregnancies. The pooled prevalence of term delivery was 46% (95% CI 31-61%) (I²=94.5%, P<0.001). The pooled prevalence of abortion was 9% (95% CI 4-14%) (I²=80%, P<0.001). Three studies reported on the number of ectopic pregnancies. The pooled prevalence of ectopic pregnancies was 5% (95% CI 2-4%) (I²=60%, P<0.001). The pooled prevalence of major congenital malformations was 2% (95% CI 1-3%) (I²=0). CONCLUSIONS: The results of this systematic review show that exposure to Ocrelizumab during conception is not associated with a higher frequency of preterm deliveries or major malformations.
Maedica (Bucur)
· 2024 Dec · PMID 39974449
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BACKGROUND: It is widely recognized that the COVID-19 pandemic has adversely affected the psychological well-being of pregnant and postpartum women. Consequently, it is of the utmost importance to identify effective stra...BACKGROUND: It is widely recognized that the COVID-19 pandemic has adversely affected the psychological well-being of pregnant and postpartum women. Consequently, it is of the utmost importance to identify effective strategies that can mitigate the negative emotional experiences of pregnant women during any pandemic period. AIM: This review seeks to identify the most effective approaches to managing stress among pregnant women during the COVID-19 pandemic and emphasizes the significance of providing support to pregnant women throughout this period. METHODS: A comprehensive literature review was conducted, and studies that met the inclusion criteria were analysed. The primary criterion was that the studies examined strategies employed by pregnant women to cope with stress during the COVID-19 pandemic. RESULTS: A total of 16 studies were included in the analysis. Adaptive coping strategies were found to be more effective in ameliorating the impact of the pandemic on mental health compared to dysfunctional coping strategies. While pregnant women generally exhibited maladaptive coping behaviours, psychological support and promoting beneficial coping strategies were the most frequently described methods for improving their mental health during the pandemic and preventing adverse outcomes of pregnancy. Additionally, avoiding misinformation and seeking social and family support were considered essential components of effective support. CONCLUSION: It is crucial to prioritize psychological, emotional and mental health support for pregnant women during the pandemic.
Duca-Barbu SA, Bratei AA, Banica DCN
… +4 more, Sajin M, Pop F, Georgescu TA, Georgescu AC
Maedica (Bucur)
· 2024 Dec · PMID 39974448
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As breast cancer is one of the leading causes of death worldwide, we aim to correlate cytonuclear morphometric parameters with clinicopathological features in order to emphasize their importance to prognostication. Follo...As breast cancer is one of the leading causes of death worldwide, we aim to correlate cytonuclear morphometric parameters with clinicopathological features in order to emphasize their importance to prognostication. Following the pathological processing of tumor specimens, representative areas throughout the tumor mass were selected. These areas have been scanned using an Olympus VS200 slide scanner and analyzed using QuPath v0.4.4. Nine cytonuclear morphometric parameters have been calculated and correlated with clinicopathological features. P values were determined through regression analysis and a p-value <0.05 was considered significant. Many significant correlations have been obtained between cytonuclear morphometric parameters and clinicopathological features. There have been elaborated mathematical criteria-based algorithms by selecting cut-off values for tubular differentiation score, nuclear pleomorphism score, mitotic rate score, Nottingham score, lymph node status, lymphovascular invasions, perineural invasion, presence of necrosis, presence of in situ carcinoma and presence of microcalcifications. The cytonuclear morphometric parameters show great promise for prognostication in breast cancer patients, as many of them were significantly correlated with clinicopathological features. The values of these parameters have allowed the development of algorithms to predict these features.
Gartaganis P, Stavrakas P, Christou EE
… +2 more, Vasalaki M, Karmiris E
Maedica (Bucur)
· 2024 Dec · PMID 39974447
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Fingolimod is an efficacious treatment option in the management of multiple sclerosis, while variable ocular adverse effects have been associated with its use. Herein, we present a case with development of central serous...Fingolimod is an efficacious treatment option in the management of multiple sclerosis, while variable ocular adverse effects have been associated with its use. Herein, we present a case with development of central serous retinopathy (CSR) in the long-term after commencement of fingolimod treatment. A 53-year-old female with relapsing-remitting multiple sclerosis presented with central vision metamorphopsia in the left eye. Medical history revealed that the patient had been on treatment with fingolimod for eight years. Ophthalmological examination revealed retinal findings suggestive of CSR changes. Given the necessity to continue fingolimod treatment, the patient commenced topical nonsteroidal anti-inflammatory (nepafenac) medication for the retinal condition. There was a prompt and successful resolution of fluid following treatment; however, a subsequent presumed ocular surface disease urged the discontinuation of anti-inflammatory drops. Four weeks later, the patient presented with recurrence of fluid in the subRPE level. Thereafter, fingolimod treatment was switched to dimethyl fumarate. The patient's condition remained clinically stable without recurrence of fluid during a three-month follow-up period. Our case provides insight into the fingolimod associated retinal findings manifesting as CSR changes, indicating that ocular complications may occur even in the long-term, while discontinuation of treatment may lead to reversal of structural findings and maintain functional outcomes.
Khavidaki GD, Gharibi R, Naderi M
… +1 more, Sedaghatkia H
Maedica (Bucur)
· 2024 Dec · PMID 39974446
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INTRODUCTION: Hearing disorders are one of the major complications in patients with thalassemia major. Therefore, the purpose of this research is to investigate hearing loss in patients with thalassemia major referred to...INTRODUCTION: Hearing disorders are one of the major complications in patients with thalassemia major. Therefore, the purpose of this research is to investigate hearing loss in patients with thalassemia major referred to Hazrat Ali Asghar Hospital in Sistan and Baluchistan province, Iran. METHODS: This cross-sectional descriptive study was conducted on 56 patients with thalassemia major who were referred to Ali Asghar Hospital in 2021-2022 and met the inclusion criteria into the present research. After obtaining the written consent of all participants, they underwent an audiometry test and were further examined. All information was collected in the researcher-made questionnaire and was analyzed using SPSS version 24 software. RESULTS: Among the 56 eligible patients, 11 subjects (19.6%) had hearing loss. In terms of age, there was no statistically significant difference in hearing loss (P<0.05). Among the 11 patients with hearing loss, one patient (9.1%) had conductive hearing loss, three patients (27.3%) had sensorineural hearing loss, one patient (9.1%) had mixed hearing loss and six patients (54.5%) had hearing loss at frequencies above 5000 Hz. In terms of gender, there was no statistically significant difference in hearing loss. The average duration of Desferal in patients with hearing loss was significantly longer than other subjects (P<0.05). CONCLUSION: To prevent and treat hearing complications caused by thalassemia, regular and periodic hearing screening of all thalassemia patients is recommended.
Maedica (Bucur)
· 2024 Dec · PMID 39974445
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Treatment for head and neck recurrent/metastatic squamous cell carcinoma (HNSCC) with immune checkpoint inhibitors has now become the new therapeutic standard, primarily replacing the EXTREME and TPex protocols that incl...Treatment for head and neck recurrent/metastatic squamous cell carcinoma (HNSCC) with immune checkpoint inhibitors has now become the new therapeutic standard, primarily replacing the EXTREME and TPex protocols that included the EGFR inhibitor Cetuximab and chemotherapy. Even if there are considerable advances in therapeutic results, less than 20% of patients with this stage of the disease survive more than four years. These results demonstrate the need to identify more effective therapies beyond simple PD1/PD-L1 blockade. Antibody-drug conjugates (ADC), vaccines, bispecific kinase inhibitors and fusion proteins involving the modulation of the tumor microenvironment are strategies to be exploited in the future. Also, in locally advanced cancers, the results of combining immunotherapy with chemoradiation treatment did not give the expected results. The use of other therapeutic sequences, including immunotherapy in association with neo-adjuvant chemotherapy, but also the association with mTOR inhibitors are also evaluated in clinical trials. We propose to present some new directions in the therapies of locally advanced relapsed or metastatic HNSCC.
Maedica (Bucur)
· 2024 Dec · PMID 39974444
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INTRODUCTION: The orthoplastic approach enables simultaneous treatment of soft tissues and fracture. The aim of the present study was to report the results of patients who received orthoplastic treatment for early postop...INTRODUCTION: The orthoplastic approach enables simultaneous treatment of soft tissues and fracture. The aim of the present study was to report the results of patients who received orthoplastic treatment for early postoperative infection after osteosynthesis of tibial plateau fractures. METHODS: From 2008 to 2018, 17 patients underwent orthoplastic surgery for early postoperative infection after internal fixation of tibial plateau fractures in our center. The median time from internal fixation to re-operation was seven weeks (4-10). Tissue cultures and sonication fluid cultures of implants were obtained. In all cases, circular external fixation was used. Soft-tissues were covered with either the medial head of gastrocnemius along with split-skin graft (13 patients) or local advancement flaps (four patients). Postoperatively, antibiotics were administered based on antimicrobial susceptibility testing. At follow-up, clinical and radiologic examination was performed to assess wound healing and fracture union. RESULTS: Circular external fixation was used for continuation of fracture stabilization in 14 patients and for knee arthrodesis due to severely damaged articular surfaces in two patients. One case was treated with anterior tibia bone transport. In all cases, bone union was achieved and skin was healed completely. SF-36 results at three years postoperatively were 61.29 ± 12.38 for the physical health component and 68.15 ± 13.34 for the mental health component. CONCLUSIONS: In the right setting and with the required expertise, single stage orthoplastic treatment is a valid option that spares the patient from the distress of multiple procedures and offers acceptable clinical outcomes.
Golpasandhagh L, Yazdanpanah A, Ariankia A
… +1 more, Dorestan N
Maedica (Bucur)
· 2024 Dec · PMID 39974443
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INTRODUCTION: Low-level laser therapy is utilized to manage postoperative pain after periodontal surgery. This study investigated the impact of low-level diode lasers at 980 and 810 nm on postoperative pain following sur...INTRODUCTION: Low-level laser therapy is utilized to manage postoperative pain after periodontal surgery. This study investigated the impact of low-level diode lasers at 980 and 810 nm on postoperative pain following surgical crown lengthening procedures. METHOD: This single-blind clinical trial and split-mouth study was conducted on 20 patients who needed bilateral crown lengthening in maxillary premolar teeth. Among samples, one side of the maxilla was randomly chosen for laser treatment and the other one for the control group. As soon as the operation was completed, the dual laser was simultaneously irradiated with 980 and 810 nm wavelengths in the test group's treatment area. Pain intensity was evaluated based on the number of analgesic capsules consumed by patients and through a visual analog scale. The data were analyzed using SPSS software version 26 through repeated measures ANOVA, paired t-test and Wilcoxon (P<0.05). RESULTS: On days one (p=0.002), two (p=0.003) and four (p=0.033), the mean pain intensity measured by VAS was significantly lower for patients following the crown lengthening surgery in the laser group compared to controls. The mean number of analgesics consumed by patients was significantly lower in the low-level laser group than the control group on days 1 (p=0.003), 2 (p=0.042) and 4 (p=0.033). Finally, pain intensity and the number of analgesics consumed by patients significantly decreased in both the control and laser groups from day 1 to day 7 (p<0.001). CONCLUSION: Simultaneous irradiation of low-level diode 980 and 810 nm lasers led to a notable decrease in pain intensity and number of analgesics used after crown lengthening respective surgery.
Popa AE, Cinteza EE, Popescu SD
… +2 more, Tecuci A, Vladareanu S
Maedica (Bucur)
· 2024 Dec · PMID 39974442
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BACKGROUND: The evaluation and management of neonatal respiratory pathologies require precise and careful diagnostic approaches, particularly in preterm infants who are at higher risk of respiratory complications. This r...BACKGROUND: The evaluation and management of neonatal respiratory pathologies require precise and careful diagnostic approaches, particularly in preterm infants who are at higher risk of respiratory complications. This research compares lung ultrasound (LUS) and chest X-ray for diagnosing and monitoring respiratory conditions in preterm and term neonates. METHODS: We conducted a prospective analysis of the imaging practices for neonatal respiratory pathologies in a cohort of 82 preterm and term infants with a gestational age ranging from 31-41 weeks presenting with respiratory distress syndrome (RDS) diagnostically categorized based on clinical and paraclinical investigations, who were admitted to the neonatal intensive care unit (NICU) immediately after birth. RESULTS: The most common diagnosis was moderate RDS, which affected 17 neonates, followed by moderate transient tachypnea of the newborn (TTN) in 16 patients, severe RDS in 14 patients and meconium aspiration syndrome (MAS) in 12 patients. Additionally, seven patients presented with mild RDS and six were diagnosed with congenital pneumonia. There were four cases of severe TTN, four cases of mild TTN and only two cases of pneumothorax. This study identified the ultrasound and radiological findings and aimed to highlight the current trend in the evaluation and management of respiratory conditions in preterm and term neonates. The results demonstrate an increasing trend in the use of ultrasound due to its advantages, especially in preterm patients who are at higher risk of respiratory impairment. CONCLUSION: The benefits of ultrasound, including absence of radiation and dynamic imaging capabilities, make it a valuable tool for ongoing assessment and management. While X-rays remain an important imaging tool in certain clinical scenarios, their use should be judicious to minimize radiation exposure. These findings support the continued integration of ultrasound in neonatal practice and suggest further research into optimizing imaging protocols to improve long-term outcomes for neonates.
Chrysovergis A, Papanikolaou V, Roukas D
… +11 more, Spyropoulou D, Mastronikoli S, Papouliakos S, Tsiambas E, Pantos P, Fotiades P, Peschos D, Ragos V, Mastronikolis N, Kyrodimos E, Niotis A
Maedica (Bucur)
· 2024 Dec · PMID 39974441
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INTRODUCTION: MicroRNAs (miRs) are crucial micro-genetic markers that significantly manipulate gene expression in neoplastic/malignant and non-neoplastic diseases, as viral infections. Different expression patterns of mi...INTRODUCTION: MicroRNAs (miRs) are crucial micro-genetic markers that significantly manipulate gene expression in neoplastic/malignant and non-neoplastic diseases, as viral infections. Different expression patterns of miRs seem to partially influence the response rates to specific chemo-targeted therapeutic regimens and prognosis in cancer patients. Concerning their nature, miRs are short non-coding RNAs including 20-25 nucleotides hosted in intra- or intergenic regions. Their most important function is the positive regulation of post-transcriptional gene silencing levels. Based on this activity, they enhance normal cell functions, including proliferation, apoptosis and tissue differentiation. Their deregulation in cancerous cells due to epigenetic and transcriptional imbalances is correlated with an excessive production of target mRNA. OBJECTIVE: In the current paper, our aim was to generally describe the role of MiRs in cancer genome and we mainly focused on specific host target-cell miRs that are affected by SARS-CoV-2 in the COVID-19 pandemic. MATERIAL AND METHOD: A systematic review of the literature was carried out based on the international database PubMed focused on miR nature, origin, structure and function in cancer genome and more recently on the influence of SARS-CoV-2 on affected cells. The following keywords were used: microRNA, SARS-CoV-2, COVID-19, infection, cancer, virus. A pool of 52 important articles were selected for the present review at the basis of exploring the SARS-CoV-2 efficacy in miRs. RESULTS: A broad set of miRs, including miR-122, miR-16-2-3p, miR-3605-3p, miR-15b-5p, miR-486-3p, miR-486-5p, miR-447b, miR-3672, miR-325, miR-447b and miR-222, has been identified to be deregulated by SARS-CoV-2 infection. CONCLUSIONS: miRs represent significant micro-epigenetic markers frequently deregulated in SARS-CoV-2 mediated infection (COVID-19). Interactions between miRs and SARS-CoV-2 RNA genome are under investigation. miR overexpression/expression loss in SARS-CoV-2 affected epithelia is correlated with specific genetic and by epigenetic signatures in the corresponding patients.
Maedica (Bucur)
· 2024 Dec · PMID 39974440
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Mechanical bowel preparation (MBP) has long been a subject of debate in colorectal surgery. While it was historically regarded as a standard preoperative practice, recent evidence has questioned its necessity and effecti...Mechanical bowel preparation (MBP) has long been a subject of debate in colorectal surgery. While it was historically regarded as a standard preoperative practice, recent evidence has questioned its necessity and effectiveness, especially when used in isolation. This review explores the evolving role of MBP, its combination with oral antibiotics (OA), and its impact on postoperative outcomes, such as surgical site infections (SSI) and anastomotic leakage (AL). Studies suggest that MBP combined with OA offers superior benefits compared to MBP alone, particularly in left-sided colorectal and rectal surgeries. However, the role of MBP remains contentious in right-sided resections, with conflicting evidence regarding its effectiveness. Furthermore, concerns about patient discomfort, dehydration, and electrolyte imbalances have raised doubts about its routine use. Our comprehensive analysis, based on 11 years of published research, highlights that the decision to employ MBP should be individualized, taking into account the type of surgical intervention, patient comorbidities and overall health status. While MBP+OA shows promise in reducing SSI rates, further research is needed to evaluate its broader clinical implications and to explore alternatives, including newer antibiotics, to minimize reliance on MBP.
Garnavou-Xirou C, Bontzos G, Smoustopoulos G
… +6 more, Velissaris S, Papadopoulos A, Georgopoulos E, Stavrakas P, Xirou T, Kozobolis V
Maedica (Bucur)
· 2024 Dec · PMID 39974439
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INTRODUCTION: Branch retinal vein occlusion (BRVO) is a leading cause of vision impairment globally and the second most common retinal vascular disease leading to blindness. Affecting over 20 million people worldwide, th...INTRODUCTION: Branch retinal vein occlusion (BRVO) is a leading cause of vision impairment globally and the second most common retinal vascular disease leading to blindness. Affecting over 20 million people worldwide, the prevalence of BRVO is expected to increase with the aging population. Branch retinal vein occlusion occurs due to the obstruction of small veins draining blood from the retina, leading to hemorrhages, fluid leakage and retinal damage. Its pathogenesis involves a complex interplay of ocular conditions and genetic predispositions. METHODS: A comprehensive literature search was conducted using PubMed and Google Scholar for articles published between January 2010 and January 2024. The search terms included "retinal vein occlusion", "BRVO" and "risk factors." After initial screening of 642 articles, non-English articles, animal studies and in vitro models were excluded. In total, 63 articles were analyzed for ocular and genetic risk factors associated with BRVO. RESULTS: Ocular risk factors for BRVO include glaucoma, short axial length and optic disc drusen. Elevated intraocular pressure in glaucoma can compress retinal veins, while short axial length increases the likelihood of venous compression. Optic disc drusen cause vascular anomalies that heighten BRVO risk. Genetic polymorphisms affecting coagulation, endothelial function, inflammation and oxidative stress, such as MTHFR C677T and Factor V Leiden, also influence BRVO susceptibility. Familial clustering and genetic variations in inflammatory pathways further contribute to the risk. CONCLUSION: The significant impact of BRVO on vision health underscores the need for comprehensive strategies for early detection, prevention and treatment. Understanding the ocular and genetic risk factors is crucial for developing personalized treatment and effective public health initiatives. Ongoing research into genetic and molecular mechanisms will enhance management approaches and improve patient outcomes.