World Journal Of Gastrointestinal Oncology[JOURNAL]
Sun
200 papers
Evaluating chat generative pretrained transformer in answering questions on endoscopic mucosal resection and endoscopic submucosal dissection.
Wang SS, Gao H, Lin PY … +3 more , Qian TC, Du Y, Xu L
World J Gastrointest Oncol · 2025 Oct · PMID 41114106 · Full text
BACKGROUND: With the rising use of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR), patients are increasingly questioning various aspects of these endoscopic procedures. At the same time, co...
BACKGROUND: With the rising use of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR), patients are increasingly questioning various aspects of these endoscopic procedures. At the same time, conversational artificial intelligence (AI) tools like chat generative pretrained transformer (ChatGPT) are rapidly emerging as sources of medical information. AIM: To evaluate ChatGPT's reliability and usefulness regarding ESD and EMR for patients and healthcare professionals. METHODS: In this study, 30 specific questions related to ESD and EMR were identified. Then, these questions were repeatedly entered into ChatGPT, with two independent answers generated for each question. A Likert scale was used to rate the accuracy, completeness, and comprehensibility of the responses. Meanwhile, a binary category (high/Low) was used to evaluate each aspect of the two responses generated by ChatGPT and the response retrieved from Google. RESULTS: By analyzing the average scores of the three raters, our findings indicated that the responses generated by ChatGPT received high ratings for accuracy (mean score of 5.14 out of 6), completeness (mean score of 2.34 out of 3), and comprehensibility (mean score of 2.96 out of 3). Kendall's coefficients of concordance indicated good agreement among raters (all < 0.05). For the responses generated by Google, more than half were classified by experts as having low accuracy and low completeness. CONCLUSION: ChatGPT provided accurate and reliable answers in response to questions about ESD and EMR. Future studies should address ChatGPT's current limitations by incorporating more detailed and up-to-date medical information. This could establish AI chatbots as significant resource for both patients and health care professionals.
-induced miR-136 is a potential predictor of early-stage gastric cancer.
Chen T, Feng AQ, Shen XR … +3 more , Dang NY, Ye F, Zhang GX
World J Gastrointest Oncol · 2025 Oct · PMID 41114105 · Full text
BACKGROUND: MicroRNAs play an important role in gastric cancer (GC) development following () infection. Yet the exact mechanism is still not fully understood. Herein, we investigated the underlying mechanisms of miR-136...
BACKGROUND: MicroRNAs play an important role in gastric cancer (GC) development following () infection. Yet the exact mechanism is still not fully understood. Herein, we investigated the underlying mechanisms of miR-136 during this process. AIM: To investigate the role of miR-136 in -induced GC progression. METHODS: GC and gastric epithelial cells were infected with and transfected with miR-136 mimic, inhibitor, mimic plus PDCD11 (identified as miR-136 target), or miR-NC (control). Cell proliferation, migration, and invasion were assessed cell counting kit-8 assay, colony formation, wound healing, and Transwell assays. Nuclear factor kappa-B (NF-κB)/miR-136/PDCD11 interactions were confirmed by luciferase and inhibition assays. For studies -infected BGC-823 cells were injected into nude mice. Reverse transcription PCR, western blot, immunohistochemistry, and immunofluorescent staining assay were used to assess mRNA and protein expression. RESULTS: miR-136 expression was significantly upregulated while PDCD11 expression was significantly downregulated in early GC tissues and GC cells infected with compared with non-infected tissues or cells (all < 0.01). miR-136 overexpression induced by could promote the proliferation and migration of infected GC cells and induce the growth of i-positive GC tumors in mice while its inhibition could reverse this effect. Mechanistically, upregulation of miR-136 suppressed PDCD11 through NF-κB activation induced by infection. CONCLUSION: miR-136 is a novel diagnostic biomarker and therapeutic target in -associated early-stage gastric carcinogenesis and acts through the NF-κB-miR-136-PDCD11 pathway.
Colorectal follicular lymphoma: A single-center retrospective study.
Saito M, Kanaya M, Miyashita N … +5 more , Yokoyama E, Izumiyama K, Mori A, Morioka M, Kondo T
World J Gastrointest Oncol · 2025 Oct · PMID 41114104 · Full text
BACKGROUND: The concept of "duodenal-type follicular lymphoma (FL)" has already been established as a disease entity. On the other hand, because FL that develops in the colorectum is a rare disease, its clinical characte...
BACKGROUND: The concept of "duodenal-type follicular lymphoma (FL)" has already been established as a disease entity. On the other hand, because FL that develops in the colorectum is a rare disease, its clinical characteristics, including its treatment and outcome, are poorly understood. AIM: To clarify the characteristic clinical features of colorectal FL. METHODS: We identified 5 patients with FL from December 2010 to July 2022 whose colorectal lesions were confirmed by endoscopic biopsy at our hospital and retrospectively examined their clinical features, including endoscopic findings, treatment, and long-term outcomes. RESULTS: The median age of the patients was 70 years (range 62-74 years, 3 males and 2 females), and 2 patients were considered to have systemic FL lesions. Endoscopic findings revealed elavated lesions in all 5 patients (polypoid 3, flat elavated 1, papular 1). Only 1 patient underwent therapeutic intervention, and 4 patients chose watchful waiting. Except for 1 patient in which the lesion spontaneously regressed, the disease recurred or progressed in 4 patients, 3 of whom eventually achieved near complete remission with the administration of rituximab and bendamustine (± polatuzumab vedotin). The 5 patients in this study were still alive or exhibited long-term survival before death; the survival time ranged from 8-29 years after the onset of lymphoma. CONCLUSION: In the present study, colorectal FL progressed slowly, and overall survival was good because it was sensitive to anticancer drugs even after the disease progressed without initial therapeutic intervention.
Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions.
Liu XX, Yang B, Tang DX
World J Gastrointest Oncol · 2025 Oct · PMID 41114103 · Full text
The initiation and progression of colorectal cancer (CRC) are profoundly influenced by the complex interplay between the gut microbiota and the immune system, underscoring the clinical importance of exploring the bidirec...
The initiation and progression of colorectal cancer (CRC) are profoundly influenced by the complex interplay between the gut microbiota and the immune system, underscoring the clinical importance of exploring the bidirectional regulatory mechanisms of the microbiota-immune axis within the CRC immune microenvironment. Emerging evidence indicates that the composition and functional capacity of the gut microbiota play a vital role in modulating the host's immune responses, while the immune system, in turn, can reciprocally regulate the structure and function of the microbiota. Despite significant insights into the role of the microbiota-immune axis in CRC progression, several critical questions remain unanswered-including how microbial heterogeneity affects therapeutic outcomes and the specific consequences of dysregulated regulatory mechanisms on the immune microenvironment. This review aims to provide a comprehensive analysis of the compositional features of the CRC immune microenvironment, examine the bidirectional molecular mechanisms underpinning the microbiota-immune axis, and evaluate the potential of targeted therapeutic strategies, thereby offering novel research perspectives and clinical applications for CRC treatment.
Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment.
Catalano M, Mini E, Nobili S … +7 more , Vascotto IA, Ravizza D, Amorosi A, Tonelli F, Roviello F, Roviello G, Nesi G
World J Gastrointest Oncol · 2025 Oct · PMID 41114102 · Full text
Ulcerative colitis (UC) is associated with an increased risk of developing colitis-associated colorectal cancer (caCRC), a major complication of long-standing disease. In this review, we examined the pathogenic associati...
Ulcerative colitis (UC) is associated with an increased risk of developing colitis-associated colorectal cancer (caCRC), a major complication of long-standing disease. In this review, we examined the pathogenic association between UC and caCRC, highlighting the risk factors, molecular mechanisms, and current strategies for prevention and management. Compared to sporadic colorectal cancer, caCRC tends to occur at a younger age and is more frequently characterized by mucinous or signet-ring cell histology, proximal colonic involvement, and a higher incidence of synchronous lesions. The risk of caCRC increases 8-10 years after UC diagnosis and is influenced by disease duration, extent of colonic involvement, inflammatory burden, family history of colorectal cancer, and coexisting primary sclerosing cholangitis. The inflammation-to-cancer progression follows a multistep pathway of genetic alterations, advancing from low-grade to high-grade dysplasia, and ultimately to carcinoma. While chemopreventive agents such as 5-aminosalicylates may offer some benefit, surveillance colonoscopy remains the primary strategy for risk reduction. Early detection and individualized prevention strategies are critical for improving long-term outcomes in patients with UC.
Clinical value of contrast-enhanced ultrasound in early diagnosis of hepatocellular carcinoma.
Dong Y, Chen LP, He JG … +2 more , Yang QQ, Hu ZW
World J Gastrointest Oncol · 2025 Oct · PMID 41114101 · Full text
BACKGROUND: Contrast-enhanced ultrasound (CEUS) offers valuable reference data for the early diagnosis of hepatocellular carcinoma (HCC) through dynamic enhancement patterns and quantitative analysis. AIM: To evaluate th...
BACKGROUND: Contrast-enhanced ultrasound (CEUS) offers valuable reference data for the early diagnosis of hepatocellular carcinoma (HCC) through dynamic enhancement patterns and quantitative analysis. AIM: To evaluate the clinical value, diagnostic accuracy, and imaging characteristics of CEUS in the early diagnosis of HCC and its correlation with HCC pathological findings. METHODS: This single-center retrospective study included 125 patients suspected of having primary liver cancer who underwent CEUS at the Department of Hepatobiliary Surgery and Imaging of our hospital from January 2022 to March 2024. All patients were diagnosed with HCC postoperative pathology or puncture histology. All patients underwent conventional ultrasound examination and CEUS, while some underwent computed tomography or magnetic resonance imaging examination. Clinical data, liver function, serological indicators, and imaging results were collected. Key CEUS indicators, including arterial phase enhancement time (APT) and peak enhancement intensity (PEI), were analyzed. RESULTS: Of the 125 patients, 66.40% were male, with a mean age of 56.74 ± 11.25 years. Conventional type HCC accounted for 71.20%, with histological grades I (14.40%), II (51.20%), and III-IV (34.40%). CEUS enhancement patterns included "fast-in and fast-out" (36%), "fast-in and slow-out" (40%), and "continuous enhancement" (24%). APT < 15 seconds was observed in 40% of patients, and PEI ≥ 1.5 in 56%. Correlation analysis revealed significant negative correlations between tumor differentiation grade and APT, washout completion time, and longest diameter ( < 0.01). Logistic regression identified PEI [odds ratio (OR) = 3.374], WIT (OR = 0.541), lesion boundary characteristics, and APT (OR = 0.471) as significant predictors. Receiver operating characteristic analysis demonstrated high diagnostic performance: PEI (area under the curve = 0.893), WIT (0.851), lesion boundary characteristics (0.876), and APT (0.864), all with Youden's index > 0.4. Subgroup analysis showed comparable overall diagnostic performance between CEUS and computed tomography/magnetic resonance imaging, but computed tomography/magnetic resonance imaging had higher sensitivity and specificity for Liver Imaging Reporting and Data System 5 lesions ( = 0.032). CONCLUSION: CEUS holds significant clinical value in the early diagnosis of HCC, as it effectively identifies the typical imaging characteristics of early-stage HCC through dynamic contrast enhancement and quantitative analysis, particularly during the arterial and portal phases. As a non-invasive, cost-effective, and efficient imaging modality, CEUS has a broad clinical application potential.
Radiomics meets sarcopenia: Machine learning-based multimodal modeling for esophageal cancer outcomes.
Peng CM, Chen CW, Hsieh CH … +6 more , Cheng YY, Liao CH, Hsieh MF, Lin SC, Liu MC, Liu YJ
World J Gastrointest Oncol · 2025 Oct · PMID 41114100 · Full text
Esophageal cancer is a highly aggressive malignancy often diagnosed at an advanced stage, with poor prognosis and high recurrence rates despite curative treatment. Accurate prognostic tools are urgently needed to guide p...
Esophageal cancer is a highly aggressive malignancy often diagnosed at an advanced stage, with poor prognosis and high recurrence rates despite curative treatment. Accurate prognostic tools are urgently needed to guide personalized management strategies. Recent research has demonstrated significant potential of integrating quantitative imaging biomarkers, specifically radiomics and sarcopenia, with machine learning (ML) techniques to enhance outcome prediction. This review systematically summarizes six recent studies (2022-2024) exploring integrated ML models combining sarcopenia and radiomics biomarkers with clinical parameters to predict survival in patients with esophageal and gastroesophageal cancers. Sample sizes ranged from 83 to 243 patients, with studies utilizing various imaging modalities (positron emission tomography/computed tomography and computed tomography) and model analysis approaches, including Cox regression, random forest, and light gradient boosting machine. These models incorporated features such as skeletal muscle indices, tumor texture, and shape descriptors. Models that combined clinical data, radiomics, and sarcopenia outperformed those using single modalities. These findings support the utility of multimodal imaging biomarkers in developing robust, individualized prognostic models. However, the retrospective nature of most studies highlights the need for standardization and external validation. This review underscores the potential of multimodal ML-based models in enhancing personalized risk stratification and treatment planning for esophageal cancer.
Multidimensional decoding of colorectal cancer heterogeneity: Artificial intelligence-enabled precision exploration of single-cell and spatial transcriptomics.
Luan WY, Zhao Q, Zhang Z … +3 more , Xu ZX, Lin SX, Miao YD
World J Gastrointest Oncol · 2025 Oct · PMID 41114099 · Full text
As a common malignant tumor, the heterogeneity of colorectal cancer plays an important role in tumor progression and treatment response. In recent years, the rapid development of single-cell transcriptomics and spatial t...
As a common malignant tumor, the heterogeneity of colorectal cancer plays an important role in tumor progression and treatment response. In recent years, the rapid development of single-cell transcriptomics and spatial transcriptomics technologies has provided new perspectives for resolving the heterogeneity of colorectal cancer. These techniques can reveal the complexity of cellular composition and their interactions in the tumor microenvironment, and thus facilitate a deeper understanding of tumor biology. However, in practical applications, researchers still face technical challenges such as data processing and result interpretation. The aim of this paper is to explore how to use artificial intelligence (AI) technology to enhance the research efficiency of single-cell and spatial transcriptomics, analyze the current research progress and its limitations, and explore how combining AI approaches can provide new ideas for decoding the heterogeneity of colorectal cancer, and ultimately provide theoretical basis and practical guidance for the clinical precision treatment.
Clinical outcomes of nursing interventions after endoscopic treatment for intestinal polyps and early-stage cancer.
Zhuang YY, Chen HY, Zhang JR … +3 more , Lai SL, Zheng YY, Huang YD
World J Gastrointest Oncol · 2025 Oct · PMID 41114098 · Full text
BACKGROUND: Implementing nursing interventions in patients undergoing endoscopic treatment for intestinal polyps and early stage cancer can serve as a reference for reducing the incidence of complications, accelerating t...
BACKGROUND: Implementing nursing interventions in patients undergoing endoscopic treatment for intestinal polyps and early stage cancer can serve as a reference for reducing the incidence of complications, accelerating the recovery process, and improving the quality of life. AIM: To impact of systematic nursing intervention on recovery, complications prevention, and quality of life after endoscopic surgery for intestinal polyps. METHODS: This retrospective study included 157 patients who underwent endoscopic mucosal resection or endoscopic submucosal dissection at our hospital. The patients were divided into intervention and conventional groups, with no significant differences in age, sex, or surgical methods. The intervention group received multidimensional nursing interventions, including preoperative evaluation, intraoperative cooperation, postoperative rehabilitation, psychological support and nutritional management. The conventional group received standardized care. Clinical efficacy, inflammation and infection indicators, complication rates, rehabilitation indicators, and visual analog scale (VAS) scores were compared. RESULTS: On the 7 day after surgery, C-reactive protein (CRP) and white blood cell levels were lower in the intervention group than in the conventional group. Complications occurred in 9.33% of the patients in the intervention group and 23.17% in the conventional group, with significant differences in fever and abdominal distension. The intervention group had shorter first exhaust and hospitalization durations than the control group. By day 3 post-surgery, the intervention group showed lower VAS scores and reduced anxiety and depression. High-risk factors included diabetes [relative risk (RR) = 2.43, 95%CI: 1.21-4.86], laparotomy (RR = 2.86, 95%CI: 1.22-6.71), CRP > 15 mg/L (RR = 3.12, 95%CI: 1.54-6.33), and procalcitonin > 0.5 ng/mL 1 day after surgery (RR = 2.91. 95%CI: 1.31-6.44), while systematic nursing interventions (OR = 0.40, 95%CI: 0.18-0.89) reduced the complication risk by 60%. CONCLUSION: Multidimensional nursing interventions have clinical value in endoscopic treatment of intestinal polyps and early stage cancer, reducing complications and hospital stay. This study provides a basis for establishing patient-centered guidelines.
Contrast-enhanced ultrasound as a non-invasive diagnostic modality for pancreatic ductal adenocarcinoma: The question of Ki67 for study validation.
Moyana TN
World J Gastrointest Oncol · 2025 Oct · PMID 41114097 · Full text
This editorial comments on Yang 's article that reported a correlation between dynamic contrast-enhanced ultrasound (CEUS) quantitative parameters and Ki67/tumor differentiation. The validation of CEUS as a diagnostic mo...
This editorial comments on Yang 's article that reported a correlation between dynamic contrast-enhanced ultrasound (CEUS) quantitative parameters and Ki67/tumor differentiation. The validation of CEUS as a diagnostic modality in this study deserves merit. However, it raises interesting points of discussion: (1) Since pancreatic cancer is an overarching term that includes conventional pancreatic ductal adenocarcinoma (PDAC), other subtypes, and neuroendocrine neoplasms (NENs), the inclusion/exclusion criteria require better clarification; (2) Most PDACs are grade 1-2 which contrasts with Yang 's study where 46% were grade 3; (3) Ki67 is officially recognized for grading NENs, but not for PDAC; (4) Hotspots are selected for the Ki67 grading of NENs. However, for other tumors ( breast carcinoma), the average count or hotspots are used; (5) There is no agreement for defining high-grade Ki67 cut-off for non-NENs; reports range from 10% to 50%; and (6) Ki67 reflects cellular proliferation but is not always the most important indicator for biologic aggressiveness. That notwithstanding, since the ratification of Ki67 for prognosis in NENs was based on survival outcomes, the real gold standard should be survival, instead of using Ki67 as a surrogate gold standard. In conclusion, the validation of CEUS parameters for PDAC is a work in progress. CEUS is valuable in assessing PDAC but should be viewed as augmenting other modalities such as computed tomography, magnetic resonance imaging, positron emission tomography and endoscopic ultrasound.
Current insights and future perspectives of treatment strategies for biliary tract cancer.
Nakagawa K, Tsujinaka S, Katayose Y … +6 more , Yambe K, Sakurai H, Takami K, Kondo N, Yamamoto K, Shibata C
World J Gastrointest Oncol · 2025 Oct · PMID 41114096 · Full text
Biliary tract cancer (BTC) is a rare disease with few available treatment options. Tumor malignancy and surgical invasiveness vary depending on the site of the lesion. Perioperative mortality remains high, particularly i...
Biliary tract cancer (BTC) is a rare disease with few available treatment options. Tumor malignancy and surgical invasiveness vary depending on the site of the lesion. Perioperative mortality remains high, particularly in patients with hilar cholangiocarcinoma and gallbladder cancer. Benchmark cases from high-volume centers have reported high surgical complications (87%) and 3-month mortality rates (13%). Japanese studies of hepatopancreatoduodenectomy have reported that although the complication rate is higher in high-volume centers than in other institutions, the mortality rate is low; operative safety depends on adequate liver volume after resection by portal vein embolization, cholangitis reduction, and comprehensive management of postoperative complications. Robot-assisted surgery is increasingly common in patients treated with pancreaticoduodenectomy even after distal pancreatectomy. However, many challenges exist due to device and visibility issues. Recently, adjuvant chemotherapies have been developed for the treatment of BTC. The introduction of immune checkpoint inhibitors and discovery of oncogenic driver genes have increased the number of promising treatment options. Innovations in targeted drug therapy, including fibroblast growth factor receptor inhibitors and immune checkpoint inhibitors, have shown efficacy and broadened the treatment options for unresectable BTC. Therefore, a multidisciplinary treatment strategy based on surgical intervention is desirable.
Revolutionizing gastrointestinal cancer research with artificial intelligence: From precision patient stratification to real-world evidence.
Wang Z, Zhang RY, Ji C … +3 more , Zhang JY, Yue BT, Wang F
World J Gastrointest Oncol · 2025 Oct · PMID 41114095 · Full text
Gastrointestinal (GI) cancers exact a staggering global toll through high incidence, mortality, and treatment costs, yet clinical research continues to be hampered by inadequate patient stratification, challenging recrui...
Gastrointestinal (GI) cancers exact a staggering global toll through high incidence, mortality, and treatment costs, yet clinical research continues to be hampered by inadequate patient stratification, challenging recruitment, suboptimal adherence, and time-consuming endpoint confirmations. Against this backdrop, artificial intelligence (AI) emerges as a powerful game-changer, offering streamlined trial design, predictive enrollment matching, dynamic endpoint assessment, and real-world data integration. This review synthesizes AI-driven advancements across the GI cancer research continuum. It covers precise patient stratification, automated efficacy evaluations, and remote compliance management. The analysis also addresses persistent challenges in data standardization, privacy protection, and regulatory oversight. We underscore the need for synergistic clinician-AI collaboration, alongside robust frameworks that ensure interpretability and ethical deployment. By illuminating the potential of AI to accelerate trial timelines, refine patient selection, and enhance outcome measurement, we aim to inspire new strategies that can significantly reduce the global burden of GI malignancies. Ultimately, this work provides a blueprint for stakeholders seeking to harness AI's transformative capabilities, fostering a future in which GI cancer clinical research becomes more agile, personalized, and impactful for patients and healthcare systems alike.
MEX3A promotes hepatocellular carcinoma cell proliferation and migration the Wnt/β-catenin and EMT pathways.
Xiao FK, Li P, Li XM … +1 more , Mi Y
World J Gastrointest Oncol · 2025 Oct · PMID 41114094 · Full text
In this paper, we focus on compelling evidence showing that MEX3A is significantly overexpressed in hepatocellular carcinoma (HCC) and correlates with poor prognosis. A recent study by Ji highlights MEX3A's role in driv...
In this paper, we focus on compelling evidence showing that MEX3A is significantly overexpressed in hepatocellular carcinoma (HCC) and correlates with poor prognosis. A recent study by Ji highlights MEX3A's role in driving proliferation and migration the RORA/β-catenin axis and epithelial-mesenchymal transition, positioning it as a potential biomarker and therapeutic target. This study addresses a critical gap in understanding HCC pathogenesis and offers valuable mechanistic insights.
Multiparametric magnetic resonance imaging-based predictive model for chemotherapy response in colorectal cancer patients with gene mutations.
Kang WY, Deng WM, Ye XQ … +4 more , Zhong YH, Li XJ, Feng LL, Luo DH
World J Gastrointest Oncol · 2025 Oct · PMID 41114093 · Full text
BACKGROUND: Patients harboring gene mutations like , , and demonstrate highly variable responses to chemotherapy, posing challenges for treatment optimization. Multiparametric magnetic resonance imaging (MRI), with its...
BACKGROUND: Patients harboring gene mutations like , , and demonstrate highly variable responses to chemotherapy, posing challenges for treatment optimization. Multiparametric magnetic resonance imaging (MRI), with its non-invasive capability to assess tumor characteristics in detail, has shown promise in evaluating treatment response and predicting therapeutic outcomes. This technology holds potential for guiding personalized treatment strategies tailored to individual patient profiles, enhancing the precision and effectiveness of colorectal cancer care. AIM: To create a multiparametric MRI-based predictive model for assessing chemotherapy efficacy in colorectal cancer patients with gene mutations. METHODS: This retrospective study was conducted in a tertiary hospital, analyzing 157 colorectal cancer patients with gene mutations treated between August 2022 and December 2023. Based on chemotherapy outcomes, the patients were categorized into favorable ( = 60) and unfavorable ( = 50) response groups. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of chemotherapy efficacy. A predictive nomogram was constructed using significant variables, and its performance was assessed using the area under the receiver operating characteristic curve (AUC) in both training and validation sets. RESULTS: Univariate analysis identified that tumor differentiation, T2 signal intensity ratio, tumor-to-anal margin distance, and MRI-detected lymph node metastasis as significantly associated with chemotherapy response ( < 0.05). Multivariate Logistics regression confirmed these four parameters as independent predictors. The predictive model demonstrated strong discrimination, with an AUC of 0.938 (sensitivity: 86%; specificity: 92%) in the training set, and 0.942 (sensitivity: 100%; specificity: 83%) in the validation set. CONCLUSION: We established and validated a multiparametric MRI-based model for predicting chemotherapy response in colorectal cancer patients with gene mutations. This model holds promise for guiding individualized treatment strategies.
Evaluation and prediction of Ki-67 expression in hepatocellular carcinoma.
Jagtap SV
World J Gastrointest Oncol · 2025 Oct · PMID 41114092 · Full text
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with hepatocellular differentiation. The diagnosis and prognosis of HCC are significantly influenced by tumor markers. Ki-67 as an immunohistochemical m...
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with hepatocellular differentiation. The diagnosis and prognosis of HCC are significantly influenced by tumor markers. Ki-67 as an immunohistochemical marker is a nuclear antigen related to the level of cell proliferation activity. Ki-67 is an important prognostic markers of HCC. In order to help clinicians assess patient outcomes, Ki67 can function as an independent prognostic indicator. In HCC, elevated Ki67 expression is linked to a worse prognosis and a higher chance of recurrence. It is considered a significant marker of clinical, histopathological, and immunological status and prognosis in HCC. Preoperative evaluation and prediction of Ki-67 expression in HCC with machine learning models based on intratumoral and peritumoral radiomic features now have a significant role in patient management and care and will provide a more definite direction for subsequent research. This article aims to evaluate the role of Ki-67 and various other biomarkers in HCC.
Effect of multidisciplinary team collaborative nursing on wound healing and psychological symptoms in postoperative patients with gastrointestinal tumors.
Huang XY, Qian D
World J Gastrointest Oncol · 2025 Oct · PMID 41114091 · Full text
BACKGROUND: Postoperative patients with gastrointestinal tumors are at high risk for poor wound healing and psychological distress, such as anxiety and depression, which can negatively impact recovery and quality of life...
BACKGROUND: Postoperative patients with gastrointestinal tumors are at high risk for poor wound healing and psychological distress, such as anxiety and depression, which can negatively impact recovery and quality of life. Multidisciplinary team (MDT) collaborative nursing has emerged as a comprehensive care approach that may address both physical and psychological needs. AIM: To explored the impact of MDT collaborative nursing on wound healing and anxiety/depression symptoms in postoperative patients with gastrointestinal tumors. METHODS: A retrospective analysis was conducted on 364 patients with gastrointestinal tumours admitted to our hospital between January 2022 and December 2024. Based on differing postoperative nursing approaches, two groups were established: the MDT group ( = 196) and the control group ( = 168). The control group received conventional nursing interventions, while the MDT group received MDT collaborative nursing. The study compared wound healing outcomes, pre-intervention and one-month post-intervention Hospital Anxiety and Depression Scale (HADS) scores, Functional Assessment of Cancer Therapy-General (FACT-G) quality of life scores, and complication rates between the two groups. RESULTS: The MDT group demonstrated a Grade A wound healing rate of 88.27% and total treatment compliance of 99.49%, both significantly higher than the control group (75.00% and 95.83%, respectively). The complication incidence rate was 3.06% in the MDT group, lower than the control group (8.93%), with all differences statistically significant ( < 0.05). After one month of intervention, patients in the MDT group demonstrated lower Anxiety Self-Rating Scale and Depression Self-Rating Scale scores on the HADS scale compared to the control group. Conversely, their scores on the FACT-G scale for physical, social/family, emotional, and functional domains were higher than those in the control group, with all differences being statistically significant ( < 0.05). CONCLUSION: MDT collaborative care promotes wound healing in patients undergoing gastrointestinal tumour surgery, alleviates anxiety and depressive symptoms, enhances treatment adherence and quality of life, and reduces the incidence of complications.
Ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis: A two-center experiment.
Huang SF, Yang F, Chen WJ … +1 more , Zhang XH
World J Gastrointest Oncol · 2025 Oct · PMID 41114090 · Full text
BACKGROUND: Childhood intestinal lymphoma is characterized by its insidious onset and the absence of specific clinical symptoms. The thinner abdominal wall in children significantly aids in the ultrasound visualization o...
BACKGROUND: Childhood intestinal lymphoma is characterized by its insidious onset and the absence of specific clinical symptoms. The thinner abdominal wall in children significantly aids in the ultrasound visualization of the abdominal cavity and intestines. Although many typical cases of intestinal lymphoma can be diagnosed through ultrasound, physicians often either overlook these values or assume that ultrasound has limited diagnostic value for intestinal lymphoma. AIM: To clarify the diagnosis of intestinal lymphoma and classify its severity using ultrasound, as well as to correlate this with prognosis. METHODS: The correlation between ultrasound diagnostic outcomes, laboratory indicators, and clinical prognosis was analyzed to demonstrate the effectiveness of ultrasound in assessing the severity of intestinal lymphoma and to provide new evidence for the diagnosis and treatment of the disease in children. A retrospective analysis was conducted on the sonographic images and case data of 28 children diagnosed with intestinal lymphoma and confirmed by surgical pathology. Additionally, we sought to determine the correlation between ultrasonic classification of lymphoma, lactate dehydrogenase (LDH) values, pathological classification, and prognosis. RESULTS: Ultrasound was utilized to categorize 28 cases of intestinal lymphoma into focal segmental (15 cases) and extensive (13 cases) types. Ultrasound classification and LDH levels were significantly correlated with prognosis ( < 0.05), while pathological type, age, gender, and treatment modality showed no significant correlation ( > 0.05). Among ultrasound manifestations, there was a significant difference in LDH levels between the segmental and extensive groups ( < 0.05). The prognosis for children with extensive intestinal lymphoma was poorer than that for children with localized segmental intestinal lymphoma ( < 0.05). CONCLUSION: Ultrasound can be used in the diagnosis and classification of intestinal lymphoma in children. Extensive intestinal lymphoma is associated with significantly elevated LDH and poor prognosis.
Postoperative immune checkpoint inhibitors plus anti-angiogenesis for hepatitis B virus-associated hepatocellular carcinoma: Analyzing the evidence and future prospects.
Krishnan A, Mukherjee D
World J Gastrointest Oncol · 2025 Sep · PMID 40977675 · Full text
A recent study by Lu examined the potential benefits of postoperative combined therapy (PCT) using anti-programmed cell death protein-1/PD-ligand-1 and anti-vascular endothelial growth factor agents for patients with he...
A recent study by Lu examined the potential benefits of postoperative combined therapy (PCT) using anti-programmed cell death protein-1/PD-ligand-1 and anti-vascular endothelial growth factor agents for patients with hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC). At the same time, the findings offer important insights; however, several methodological and statistical limitations should be noted. These limitations include selection bias from the study's retrospective design, variability in treatment regimens, a small sample size, and inadequate monitoring of hepatitis B virus (HBV) reactivation. The study's conclusions about PCT efficacy warrant cautious interpretation due to unresolved biases. Prospective trials with biomarker stratification are critical to confirm these preliminary findings. These findings underscore the need for prospective, biomarker-driven trials to validate the efficacy of PCT. Future research should prioritize standardized regimens, HBV reactivation monitoring, and global collaborations to optimize therapeutic strategies for HBV-HCC.
Quantitative immunohistochemistry analysis of pancreatic adenocarcinoma upregulated factor expression in pancreatic cancer and its prognostic significance.
Kim JH, Na HY, Jung K … +5 more , Jang D, Youn Y, Kim DH, Han HD, Hwang JH
World J Gastrointest Oncol · 2025 Sep · PMID 40977674 · Full text
BACKGROUND: Among all solid tumors, pancreatic ductal adenocarcinoma (PDAC) is characterized by markedly poor survival outcomes, reflecting its high lethality, primarily as a result of late-stage diagnosis and limited tr...
BACKGROUND: Among all solid tumors, pancreatic ductal adenocarcinoma (PDAC) is characterized by markedly poor survival outcomes, reflecting its high lethality, primarily as a result of late-stage diagnosis and limited treatment options. Pancreatic adenocarcinoma upregulated factor (PAUF) displays elevated expression in PDAC compared to non-neoplastic pancreatic samples and is involved in promoting tumor development. However, its exact diagnostic and prognostic significance remains unclear. This study aimed to assess the clinical relevance of PAUF expression in PDAC. We hypothesized that higher PAUF expression is associated with more aggressive clinicopathological features and poorer patient outcomes. AIM: To investigate the expression of PAUF in PDAC and its value as a diagnostic and prognostic biomarker. METHODS: PAUF expression levels were assessed using immunohistochemistry in tumor tissues from 93 patients with PDAC. Staining intensity and the proportion of tumor cells showing PAUF positivity were assessed to categorize patients into low and high PAUF expression groups. Associations between PAUF expression and clinicopathological characteristics or survival outcomes were analyzed. Public datasets (The Cancer Genome Atlas, Genotype-Tissue Expression, and Clinical Proteomic Tumor Analysis Consortium) were employed to validate differences in PAUF expression in PDAC at mRNA and protein levels. RESULTS: PAUF expression was observed in 82.8% of samples, primarily localized within the cytoplasm of tumor cells. High PAUF expression showed a significant correlation with metastasis to lymph nodes (78.4%, = 0.0019), indicating a strong association with advanced disease. Public datasets confirmed elevated PAUF levels at both transcript and protein levels in PDAC relative to normal tissue. Kaplan-Meier estimates indicated that higher PAUF levels were linked with shorter overall survival (18.4 months 32.7 months, = 0.032). Multivariate Cox regression confirmed high PAUF expression as a prognostically significant variable contributing to poor clinical outcomes [hazard ratio (HR) = 2.05; = 0.009]. Poor tumor differentiation (HR = 2.47; = 0.004) and lack of adjuvant therapy (HR = 0.39; = 0.001) were also independently associated with unfavorable outcomes. CONCLUSION: PAUF is a promising biomarker for tumor progression and prognosis in PDAC, with potential clinical utility in early diagnosis and the development of targeted therapies.
Untargeted metabolomics analysis of metabolite changes in gastric cancer patients from plateau regions.
Zhu LH, Jin ZX, Ma YQ … +6 more , Feng X, Ci CH, Zhou YS, Gu QL, Lan YM, Zhang ZL
World J Gastrointest Oncol · 2025 Sep · PMID 40977673 · Full text
BACKGROUND: Metabolomics sequencing technology was used to investigate the changes of intestinal flora and metabolites in gastric cancer patients in plateau areas. AIM: To investigate changes in gut microbiota and their...
BACKGROUND: Metabolomics sequencing technology was used to investigate the changes of intestinal flora and metabolites in gastric cancer patients in plateau areas. AIM: To investigate changes in gut microbiota and their metabolites in patients with gastric cancer from plateau regions using untargeted metabolomic sequencing. METHODS: Fresh morning fecal samples were collected from 30 gastric cancer patients diagnosed at a tertiary hospital in Qinghai Province and 30 healthy individuals (controls). Liquid chromatography-tandem mass spectrometry based untargeted metabolomic sequencing was used to analyze metabolite changes and predict metabolic function. RESULTS: Metabolomic analysis identified 281 metabolites in samples from both groups. These metabolites were categorized into eight major classes, listed in descending order of abundance: Lipids and lipid-like molecules (35.443%); organic acids and derivatives (29.114%); organic oxygen compounds (15.19%); nucleosides, nucleotides, and analogs (13.924%); organoheterocyclic compounds (2.532%), amino acids and peptides (1.266%); benzenoids (1.266%); and fatty acids (1.266%). Compared with the control group, the top 10 metabolites elevated in the gastric cancer group included: Dethiobiotin, glycylproline, glycine, hydroxyisocaproic acid, tyramine, methionine sulfoxide, 5-aminopentanoic acid, citrulline, betonicine, and formiminoglutamic acid and the top 10 decreased were: Cytidine, 5'-methylthioadenosine, trehalose, melibiose, lotaustralin, adenosine, inosine, ribothymidine, raffinose, and galactinol. Functional prediction analysis revealed that these differential metabolites were primarily enriched in 12 metabolic pathways, including purine metabolism, cysteine and methionine metabolism, galactose metabolism, lysine degradation, glycine, serine, and threonine metabolism, biotin metabolism, pyrimidine metabolism, arginine and proline metabolism, histidine metabolism, primary bile acid biosynthesis, starch and sucrose metabolism, and tyrosine metabolism. CONCLUSION: Significant differences in intestinal microbial metabolites and associated metabolic pathways were observed between gastric cancer patients and healthy controls residing in plateau regions.
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