Folia Medica Cracoviensia[JOURNAL]
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200 papers
Anesthesia for gynecological cancer surgery.
Krawczyk P, Lonc T, Świstek R … +2 more , Tyszecki P, Andres J
Folia Med Cracov · 2022 Sep · PMID 36309829 · Publisher ↗
Malignant neoplasms are currently a severe medical challenge and the second leading cause of death worldwide. The modern anesthesia applied may improve the patient outcome. This paper presents a review of anesthesia mana...
Malignant neoplasms are currently a severe medical challenge and the second leading cause of death worldwide. The modern anesthesia applied may improve the patient outcome. This paper presents a review of anesthesia management related to patients with gynaecologic malignancies. It includes the influence of the type of anesthesia on cancer recurrence, application of regional anesthesia in gynaecologic oncologic surgery, and selected aspects of anesthesia for robotic surgery. We performed a literature search on MEDLINE, EMBASE, Google Scholar, the Cochrane Central Register of Controlled Trials, and Clinical Trials. The database search focused on the topics related to anesthesia in gynecological oncology. The authors also contributed through individual, independent literature searches.
The Inhibitory Effect of Human Plasma Albumin and Haptoglobin on Platelet Aggregation and 5-HT Release.
Khan N, Kurnik-Łucka M, Latacz G … +2 more , Gil K, Saeed SA
Folia Med Cracov · 2022 Sep · PMID 36309828 · Publisher ↗
Platelet aggregation contributes to the pathogenesis of cardiovascular diseases. After activation it leads to dense granule secretion and 5-HT release. The question arises; how platelet aggregation is endogenously contro...
Platelet aggregation contributes to the pathogenesis of cardiovascular diseases. After activation it leads to dense granule secretion and 5-HT release. The question arises; how platelet aggregation is endogenously controlled during blood circulation. In preliminary studies, we observed that human platelets aggregate more rapidly when suspended in buffer as compared to those suspended in plasma (PRP). These observations point to the presence of an endogenous substance that may inhibit arachidonic acid- induced platelet aggregation. An analysis of plasma Cohn fractions demonstrated that most of the plasma inhibitory activity was associated with albumin-rich and α-globulin rich protein fractions. The identity of plasma endogenous inhibitors of platelet aggregation (EIPA) was established by affinity chromatography on Cibacron Blue F3G-A for specific removal of albumin. The association of α-globulins to EIPA activity was recognized as due to haptoglobin by affinity chromatography on a column of hemoglobin-sepharose. In addition, we also found that the distribution of EIPA activity varies according to sex and physiological state. These findings reveal that EIPA may act by modulation of arachidonic acid metabolism or sequestering the fatty acid substrate.
A comparison of temporomandibular disorder headache in young adults in relation to perceived stress.
Wieczorek A, Pihut M, Loster JE
Folia Med Cracov · 2022 · PMID 36256900 · Publisher ↗
Chronic pain in the head and face region has a predicted prevalence of 20% in Europe, and is more common in women than men. The etiology of temporomandibular disorder (TMD) is multifactorial, and high levels of psycholog...
Chronic pain in the head and face region has a predicted prevalence of 20% in Europe, and is more common in women than men. The etiology of temporomandibular disorder (TMD) is multifactorial, and high levels of psychological stress amplify its symptoms. We were interested in how headache reported in RDC/TMD is associated with stress. Individuals with an average age of 18 years were included in the study. They were all volunteer participants in a research project. Clinical evaluation of each subject was performed using the RDC/TMD dual-axis diagnostic system. All participants filled out the PSS-10 questionnaire. A total of 138 individuals participated in the study, of which 107 were female. Headache was reported by 83 participants (59.4%), with females presenting higher scores on the PSS-10; this was statistically significant. A comparison between PSS-10 questionnaire results and headache level shows insignificant differences. However, the higher the stress level in the participant, the higher the headache score. Females are more susceptible to perceived stress, which can have an effect on TMD.
Differential diagnosis of temporomandibular disorders - a review of the literature.
Krasińska-Mazur M, Homel P, Gala A … +2 more , Stradomska J, Pihut M
Folia Med Cracov · 2022 · PMID 36256899 · Publisher ↗
Pain in the masticatory muscles or temporomandibular joints may in some cases be a symptom of other afflictions occurring in this region. The aim of the study was to present the differential diagnosis of temporomandibula...
Pain in the masticatory muscles or temporomandibular joints may in some cases be a symptom of other afflictions occurring in this region. The aim of the study was to present the differential diagnosis of temporomandibular disorders (TMD) and other diseases in the craniofacial area, based on review of the literature. Using the key words: "differential diagnosis of TMD", "pain of non-dental origin" and "chronic orofacial pain", PUBMED and Scopus databases were systematically searched for articles in English from 2005 to 2020. Additionally, the PUBMED database was supplementarily reviewed using the keywords "Lyme disease orofacial symptoms" for the English-language articles published in the years 1996-2020. Out of 445 publications from PUBMED and Scopus databases as well as other sources, 57 articles describing the pathogenesis and characteristic symptoms of diseases that may cause pain similar to that occurring in TMD as well as diagnostic methods used in differential diagnosis of TMD were selected for analysis. Dental and jawbones-related conditions, ear and maxillary sinus diseases, as well as ailments of neuropathic and vascular origin, were taken into account. Neoplastic processes taking place in this region and less often occurring diseases caused by viruses, bacteria and parasites were also described. Conclusions. Correct diagnosis of temporomandibular disorders is based on medical history and thorough physical examination, as well as results of additional tests. Pain localized in the head and neck structures may have diverse, sometimes complex aetiology, and may require multidisciplinary treatment. Observation of the patient's behaviour and - in selected cases - the results of additional laboratory tests, also play a significant role.
Arterial stiffness - a cardiovascular risk factor to assess among primary care patients.
Kamieńska A, Chlabicz S
Folia Med Cracov · 2022 · PMID 36256898 · Publisher ↗
Arterial stiffness is a characteristic of the arterial wall strongly associated with ageing and hypertension. It has been confirmed as a significant cardio-vascular risk factor. Despite available non- invasive measuremen...
Arterial stiffness is a characteristic of the arterial wall strongly associated with ageing and hypertension. It has been confirmed as a significant cardio-vascular risk factor. Despite available non- invasive measurement methods of central artery stiffening, it has not become a prevalent diagnostic marker in primary care so far. This article provides an overview of pathophysiology of arterial stiffness, possible diagnostic techniques, association with cardiovascular conditions and potential perspective of primary care to implement an additional distinctive parameter to evaluate cardiac risk.
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P … +6 more , Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov · 2022 · PMID 36256897 · Publisher ↗
Tenosynovial Giant Cell Tumor (TGCT) is a group of typically benign lesions arising from the synovium of joints, bursae and tendon sheaths. Depending on their growth pattern and clinical course, they are divided into loc...
Tenosynovial Giant Cell Tumor (TGCT) is a group of typically benign lesions arising from the synovium of joints, bursae and tendon sheaths. Depending on their growth pattern and clinical course, they are divided into localized and diffuse types. It is predominantly caused by a mutation in the stromal cells of the synovial membrane leading to overexpression of the colony stimulating factor 1 that recruits CSF1R-expressing cells of the mononuclear phagocyte lineage into the tumor mass. The lesions contain mainly histiocyte-like and synovial cells accompanied by varying numbers of multinucleated giant cells, mononuclear cells, foam cells, inflammatory cells and hemosiderin deposits. The gold standard for detect- ing and monitoring the disease is MRI, where the characteristic hemosiderin accumulation can be best appreciated, but it is a histological examination that is most conclusive. The main treatment is surgical resection of all pathological tissue, but radio- and chemotherapy are also viable options for certain groups of patients.
The growing need for reliable online health information during lockdown in Europe: An infodemiologic analysis of myocardial infarction management in the COVID-19 era.
Felkle D, Korman MŁ, Surdacki A
Folia Med Cracov · 2022 · PMID 36256896 · Publisher ↗
I n t r o d u c t i o n: The COVID-19 pandemic has put healthcare systems worldwide under huge strain, resulting in a significant loss of their capacity and availability. Patients have become more reluctant to contact th...
I n t r o d u c t i o n: The COVID-19 pandemic has put healthcare systems worldwide under huge strain, resulting in a significant loss of their capacity and availability. Patients have become more reluctant to contact their doctors or call an ambulance in case of myocardial infarction (MI) symptoms onset. It has been accompanied by a significant decrease in the number of coronary angiography and PCI procedures performed. O b j e c t i v e s: The aim of the study is to evaluate the role of online health information in the patient- dependent phase of MI management during the COVID-19 lockdown in Europe. Methods: We analyzed Google Trends data on the popularity of phrases related to MI symptoms, respiratory tract infection, urological complaints, and terms unrelated to health, for the period of the first COVID-19 lockdown, along with the data from the corresponding weeks from 2017-2019 in seven European countries. R e s u l t s: The search volume for particular symptoms of myocardial infarction increased in all studied countries, compared to the analogous period from 2017-2019, with a significant increase in for chest pain, shortness of breath, fear, and palpitations in most countries. These changes have not been accompanied by increased interest in terms related to respiratory tract infection symptoms and urological complaints. C o n c l u s i o n s: Our findings suggest that during lockdown, patients with MI symptoms may have tried to manage their complaints on their own, using information from the Internet. This demonstrates the growing role of the Internet in the patient's decision-making process in the emergency situation, indicating a growing need for reliable and freely available online information provided by healthcare professionals.
Medical students' perception of e-learning approach (MeSPeLA) - a mixed method research.
Püsküllüoğlu M, Nowakowski M, Ochenduszko S … +2 more , Hope D, Cameron H
Folia Med Cracov · 2022 · PMID 36256895 · Publisher ↗
There is a discrepancy between the research exploring e-learning at medical universities in Central/Eastern and Western European countries. The aim of the MeSPeLA study was to explore the understanding, experience and ex...
There is a discrepancy between the research exploring e-learning at medical universities in Central/Eastern and Western European countries. The aim of the MeSPeLA study was to explore the understanding, experience and expectations of Polish medical students in terms of e-learning. Questionnaire containing open-ended and closed questions supplemented by focus group discussion was validated and performed among 204 medical students in Poland before COVID-19 pandemia. Several domains: understanding of e-learning definitions; students' experience, preferences, expectations and perceptions of e-learning usefulness, advantages and disadvantages were addressed. The qualitative data were analyzed using an inductive approach. 46.0% of students chose a communication-oriented definition as the most appropriate. 7.4% claimed not to have any experience with e-learning. 76.8% of respondents indicated they had contact with e-learning. The main reported e-learning advantages were time saving and easier time management. The most common drawback was limited social interactions. The acceptance of the usage of e-learning was high. Medical undergraduates in Poland regardless of the year of studies, gender or choice of future specialization showed positive attitudes towards e-learning. Students with advanced IT skills showed a better understanding of the e-learning definition and perceived e-learning to be a more useful approach. The expectations and perceptions about e-learning in Polish medical schools seems similar to some extent to that in Western European and the United States so we can be more confident about applying some lessons from these research to Poland or other post-communist countries. Such application has been accelerated due to COVID-19 pandemia.
New insights on the link between body composition, nutritional status and physical performance in elderly outpatients.
Fatyga-Kotula P, Wizner B, Fedyk-Łukasik M … +2 more , Grodzicki T, Skalska A
Folia Med Cracov · 2022 · PMID 36256894 · Publisher ↗
OBJECTIVES: The aim of the study was to assess the relationship between body composition, nutritional status and physical ability in elderly outpatients. METHOD: . In this cross-sectional study, demographic data and medi...
OBJECTIVES: The aim of the study was to assess the relationship between body composition, nutritional status and physical ability in elderly outpatients. METHOD: . In this cross-sectional study, demographic data and medical history were collected from patients aged ≥60 years followed in the Geriatric Outpatient Clinic from October 2010 to February 2014. Body composition was examined using a dual-energy X-ray absorptiometry. Physical performance was assessed by gait speed (GS), Timed Up&Go Test (TUG), Six Minute Walk Test (6MWT). The nutritional status was evaluated using the Mini Nutritional Assessment (MNA) and serum albumin level. RESULTS: Mean age (± SD) of 76 patients (64.47% men) was 71.93 ± 8.88 yrs. The most common diseases were: hypertension (89.47%), coronary heart disease (81.58%) and chronic heart failure (68.4%). In multiple regression analyses, the factors significantly affecting GS were: age (B = - 0.017, p ≤0.0001), good nutritional status (B = 0.038, p <0.01) and percent of lower extremity fat (B = - 0.009, p <0.05). Longer TUG time was associated with poorer nutritional status (B = -0.031, p <0.01), older age (B = 0.01, p <0.01) and a higher number of comorbidities (B = 0.034, p <0.05). 6MWT was influenced negatively by age (B = -3.805, p <0.01) and percent of lower extremity fat (B = -2.474, p <0.05). CONCLUSIONS: Age and nutritional status remain a strong determinant of physical fitness deterioration. Different measures of physical performance are influenced by different elements of body composition - no single element of body composition was found determining the deterioration of all assessed parameters of physical fitness. Identifying the relationship between body composition, nutritional status and physical performance can help elucidate the causes of disability and target preventive measures.
The influence of 5-fluorouracil on the α-ketoglutarate dehydrogenase complex in rat's cardiac muscle - a preliminary study.
Knapik-Czajka M, Gawędzka A, Jurczyk M … +5 more , Drąg J, Belczyk M, Aleksanrovych V, Gil A, Gil K
Folia Med Cracov · 2022 · PMID 36256893 · Publisher ↗
5-fluorouracil (5-FU), which is a commonly used chemotherapy agent exerts undesired cardiac toxicity. Mitochondrial dysfunction is thought to be one of potentially important mechanisms of 5-FU- induced cardiotoxicity. α-...
5-fluorouracil (5-FU), which is a commonly used chemotherapy agent exerts undesired cardiac toxicity. Mitochondrial dysfunction is thought to be one of potentially important mechanisms of 5-FU- induced cardiotoxicity. α-ketoglutarate dehydrogenase (α-KGDHC) is the key regulatory enzyme of TCA cycle. The complex consists of multiple copies of three catalytic subunits: α-ketoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). α-KGDHC together with branched chain α-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase (PDH), are the members of 2-oxoacid dehydrogenases family that share some structural and functional similarities. Recently, it has been found that 5-FU stimulates BCKDH in rat's cardiac muscle. Therefore, we hypothesize that 5-FU modifies α-KGDHC activity and affects cardiac muscle metabolism. The aim of this study was to determine the effect of 5-FU on α-KGDHC activity and protein levels of E1 and E2 subunits of the complex in rat's cardiac muscle. Wistar male rats were administered with 4 doses of 5-FU, 150 mg/ kg b.wt. each (study group) or 0.3% methylcellulose (control group). α-KGDHC activity was assayed spectrophotometrically. The E1 and E2 proteins levels were quantified by Western blot. 5-FU administration resulted in stimulation of myocardial α-KGDHC activity in rats. In addition, E2 protein level increased in response to 5-FU treatment, while the E1 protein level remained unchanged. Up-regulation of α-KGDHC appears to result from change in E2 subunit protein level. However, the effect of 5-FU on factors modifying α-KGDHC activity at post-translational level cannot be excluded.
Penetration of the posterior interosseous nerve fibers into the dorsal capsule of the wrist - a new perspective on wrist innervation.
Bonczar M, Bonczar T, Ostrowski P … +8 more , Dziedzic M, Bonczar M, Plutecki D, Gil A, Jasińska M, Lis G, Walocha J, Koziej M
Folia Med Cracov · 2022 · PMID 36256892 · Publisher ↗
The dorsal capsule of the wrist and the DCSS may play a significant role in the conduction of nerve signals transmitted from proprioceptors present in SL to PIN, which is located above the dorsal capsule. Hence, this stu...
The dorsal capsule of the wrist and the DCSS may play a significant role in the conduction of nerve signals transmitted from proprioceptors present in SL to PIN, which is located above the dorsal capsule. Hence, this study aimed to determine if nerve fibers of PIN penetrate inside the dorsal capsule. The dorsal capsules of the wrist were dissected from both sides from 15 cadavers. Eventually, 30 dorsal capsules were dissected. It can be concluded that the PIN nerve fibers penetrate the dorsal capsule of the wrist, as the penetration was noticeable in every part evaluated. The present study proves that afferent fibers from the mechanoreceptors of the SLIL potentially pass through the DCSS and subsequently through the dorsal capsule of the wrist to the PIN. This knowledge can surely be of great use for hand surgeons that perform procedures on the dorsal wrist.
Teledentistry and oral health in older adults - aspects for implementation of the "Patient centric solution for smart and sustainable healthcare (ACESO)" project.
Gryglewska B, Perera I, Klimek E … +5 more , Fedyk-Łukasik M, Piotrowicz K, Mocanu I, Muntianu L, Gąsowski J
Folia Med Cracov · 2022 · PMID 36256891 · Publisher ↗
P u r p o s e: Oral health and diseases are significant components of general health. However, oral health-care remains at the lowest of older patients' priorities. The inability to obtain dental care can result in progr...
P u r p o s e: Oral health and diseases are significant components of general health. However, oral health-care remains at the lowest of older patients' priorities. The inability to obtain dental care can result in progression of dental disease, leading to a diminished quality of life and overall health. Teledentistry (TD) provides an opportunity to improve the quality of oral health services. The aim of our narrative review was to analyze the usefulness of teledentistry as a part of telemedicine to improve oral health in the elderly. Materials/Methods: The PubMed database search was done for: teledentistry, oral health, oral- health related diseases, elderly, older adults. R e s u l t s: The applicability of TD has been demonstrated from children to older adults. Older adults have many obstacles in getting oral health care, including low income, lack health insurance, frailty, anxiety, depression, mobility problems or other handicaps. Available data suggests that the usefulness of TD in the provision of oral care in elderly people living in residential aged care facilities. Moreover, TD procedures were found to be as accurate as traditional face-to-face dental examinations, they was cost-effective and well accepted among patients and caregivers. C o n c l u s i o n s: TD might be a very useful tool for professional education, improving access and patient satisfaction of dental care. However, such TD modes would be difficult to widely implementation in community-dwelling older people who cannot access dental care. The ongoing "Patient centric solution for smart and sustainable healthcare (ACESO)" project will add to the intelligent oral health solutions.
Oral Health Impact Profile in adult Polish population.
Wąsacz K, Hukowska D, Chomyszyn-Gajewska M
Folia Med Cracov · 2022 Jun · PMID 36088598 · Publisher ↗
BACKGROUND: Oral Health Related Quality of Life (OHRQoL) is a significant patient-oriented outcome which should be considered in diagnostic, decision making and therapeutic process by dentists. OBJECTIVES: To evaluate th...
BACKGROUND: Oral Health Related Quality of Life (OHRQoL) is a significant patient-oriented outcome which should be considered in diagnostic, decision making and therapeutic process by dentists. OBJECTIVES: To evaluate the influence of a condition of teeth, oral mucosa and dentures on the OHRQoL among patients seeking dental treatment in the University Dental Clinic (UDC) in Kraków, Poland. MATERIAL AND METHODS: 250 patients took part in a cross-sectional study conducted in the UDC in Kraków. Collected clinical data included: oral mucosa and periodontal condition, number of Decayed, Missed and Filled Teeth (DMFT index), presence of dentures. Questionnaire part of the study has been based on OHIP-14 questionnaire. RESULTS: The condition of teeth worsened OHRQoL in following groups of patients: first-time visitors, smokers, with periodontal diseases and without oral mucosal diseases. There was a positive significant correlation between number of decayed teeth and OHRQoL related to teeth. The condition of oral mucosa significantly impaired OHRQoL in: women, patients with oral mucosal diseases and those who undergone prosthetic treatment in the last year. There was a correlation between number of missing teeth, DMFT index, age and subscale 2 of the form. The condition of dentures significantly impaired the OHRQoL in patients: who used removable dental prostheses, undergone prosthetic treatment in the last year and females. There was a positive correlation between subscale 3 of the questionnaire and number of missing teeth and DMFT index and a negative correlation with number of filled teeth within this subscale. CONCLUSIONS: Evaluation of patient's OHRQoL is one of important components for successful dental treatment.
Patient's knowledge of daily activities, need for information and quality of life after cardiac electronic device implantation.
Góral S, Teliżyn M, Rajzer M … +1 more , Olszanecka A
Folia Med Cracov · 2022 Jun · PMID 36088597 · Publisher ↗
INTRODUCTION: Cardiac implantable electronic devices (CIED) such as pacemakers or cardioverter defibrillators prevent dangerous heart arrhythmias and conduction abnormalities. Post-intervention education is crucial in th...
INTRODUCTION: Cardiac implantable electronic devices (CIED) such as pacemakers or cardioverter defibrillators prevent dangerous heart arrhythmias and conduction abnormalities. Post-intervention education is crucial in the patient recovery process and aims to avoid both dangerous behavior and unnecessary restraints in daily living. OBJECTIVE: The evaluation of knowledge of daily activities' safety among patients with CIEDs and an analysis of the relationship between the state of knowledge and perceived post-intervention quality of life. MATERIALS AND METHODS: The study group included 100 patients (57% men) with CIEDs, recruited in the University Hospital in Kraków. Data on the patients' knowledge about permissible daily activities, medical procedures and perceived quality of life was collected using a dedicated questionnaire, which comprised 57 simple and multiple-choice questions. RESULTS: The analyzed group included patients aged 28 to 97 years (mean age 73). Among them, 26% either have not received or have not read the information booklet. Two-thirds of them either need more information about their device (51%) or do not possess essential knowledge (15%). Patients raised concerns about performing daily activities such as: car-driving (38%), using seat belts (14%), bathing (15%), returning to work (51%) or climbing stairs (16%). They reported anxiety when using computers (39%), mobile phones (51%), microwaves (73%) and even electric toothbrushes (51%). It has been observed that patients with a greater general understanding of the pacemaker and post-implantation restraints had a higher quality of life on average. CONCLUSIONS: Patients with CIEDs restrain themselves excessively in daily living. There is a strong need to provide them with knowledge of their medical condition, concomitant capabilities, and limitations to undergo a fully successful rehabilitation. Comprehensive and easily comprehensible recommendations may play a key role in improving patients' quality of life.
Forecasting of COVID-19 incidence in Ukraine using the method of exponential smoothing.
Malysh N, Podavalenko A, Kuzmenko O … +1 more , Kolomiets S
Folia Med Cracov · 2022 Jun · PMID 36088596 · Publisher ↗
Coronavirus infection (COVID-19) is a highly infectious disease of viral etiology. SARS-CoV-2 virus was first identified during the investigation of the outbreak of respiratory disease in Wuhan, China in December 2019. A...
Coronavirus infection (COVID-19) is a highly infectious disease of viral etiology. SARS-CoV-2 virus was first identified during the investigation of the outbreak of respiratory disease in Wuhan, China in December 2019. And already on March 11, 2020 COVID-19 in the world was characterized by the WHO as a pandemic. In Ukraine the situation with incidence COVID-19 remains difficult. The purpose of this study is to to develop a mathematical forecasting model for COVID-19 incidence in Ukraine using an exponential smoothing method. The article analyzes reports on basic COVID-19 incidence rates from 29.02.2019 to 01.10.2021. In order to determine the forecast levels of statistical indicators that characterize the epidemic process of COVID-19 the method of exponential smoothing was used. It is expected that from 29.02.2019 to 01.10.2021 the epidemic situation of COVID-19 incidence will stabilize. The indicator of "active patients" will range from 159.04 to 353.63 per 100 thousand people. The indicator of "hospitalized patients" can reach 15.43 and "fatalities" ‒ 1.87. The use of the method of exponential smoothing based on time series models for modeling the dynamics of COVID-19 incidence allows to develop and implement scientifically sound methods in order to prevent, quickly prepare health care institutions for hospitalization.
The importance of the quality of information and the methods of its distribution in the process of promoting a healthy lifestyle.
Fałek A, Burdan F
Folia Med Cracov · 2022 Jun · PMID 36088595 · Publisher ↗
Each piece of information is distributed in the form of a message. Its character takes various forms, it can be expressed by words or in images. It is the visual form which is the most effective tool of influence. Graphi...
Each piece of information is distributed in the form of a message. Its character takes various forms, it can be expressed by words or in images. It is the visual form which is the most effective tool of influence. Graphic signs are often used to convey or exchange thoughts. The signs have an informative function but they are also meant to force a specific behavior. Such a change in expectations and beliefs of a specific regulator is called the social impact. The intensity of interpersonal relationships is deliberately stimulated through an appropriate form of communication. The more expressive and emotional is its character, the greater the benefits for the quality of communication in the process of promoting healthy behaviors.
LC/MS/MS assessment of changes in placental angiotensin I metabolism in preeclampsia.
Stettner-Kołodziejska D, Bujak-Giżycka B, Wiśniewska A … +6 more , Łomnicka M, Kołodziejski M, Wiecheć M, Rytlewski K, Huras H, Olszanecki R
Folia Med Cracov · 2022 Jun · PMID 36088594 · Publisher ↗
BACKGROUND: Preeclampsia (PE) is a condition characterized by high blood pressure and significant proteinuria in pregnant women. It affects about 7% pregnancies and can be cause of fetal and maternal morbidity and mortal...
BACKGROUND: Preeclampsia (PE) is a condition characterized by high blood pressure and significant proteinuria in pregnant women. It affects about 7% pregnancies and can be cause of fetal and maternal morbidity and mortality. During pregnancy, a physiological overexpression of the Renin-Angiotensin System (RAS) components is observed, including increased plasma Ang II level. Dysregulation of RAS in placenta may contribute to preeclampsia and uterine growth retardation. The aim of the study was to evaluate the Ang I metabolism in human preeclamptic placentas and to compare to normal pregnancies condition. METHOD: Fragments of placental tissues were collected right after ceasarian section from PE and physiological pregnancies. Tissues were incubated in Krebs buffer in the presence of Ang I. Evaluation of Ang I metabolites in incubating fluid was performed by LC/MS/MS method. mRNA expression of main RAS components was measured by RT-PCR. RESULTS: Pattern of angiotensin metabolites did not differ between groups. The main products were Ang 1-7 and Ang II. Comparing to control group, more than 3-fold lower production of Ang II and Ang 1-7 in preeclampsia was observed. mRNA expressions of ACE and AT1 were significantly decreased in pre- eclamptic placentas, whereas higher expression of mRNA of ACE2 and MAS receptor were observed. CONCLUSIONS: Production of Ang 1-7 by PE placentas was significantly lower than in control group. Significantly decreased mRNA expression of ACE and AT1 receptor and lower production of Ang II in placentas of PE patients suggest that placental Ang II/ACE/AT1r pathway could be less important than Ang 1-7/ACE-2/MASr pathway in development of preeclampsia, but this requires further investigations.
Arthrofibrosis - a myth or true joint disorder?
Walocha A, Rutowicz B, Przybycień W … +7 more , Zarzecki M, Kłosiński M, Depukat P, Solewski B, Mizia E, Gil A, Walocha E
Folia Med Cracov · 2022 Jun · PMID 36088593 · Publisher ↗
Authors, mostly specialists on rehabilitation and orthopedic surgery prove that arthrofibrosis is a commonly overlooked phenomenon, which may lead to serious limitation in the range of movement, leading to limitation in...
Authors, mostly specialists on rehabilitation and orthopedic surgery prove that arthrofibrosis is a commonly overlooked phenomenon, which may lead to serious limitation in the range of movement, leading to limitation in patients quality of functioning. The main goal of this article is to emphasize the importance of understanding a such complex condition. Non typical patomechanism, lack of biomarkers dedicated to this dysfunction and general lack of understanding in this pathology causes that risk factors and the most effective strategies remain vastly unknown. Pathophysiology of the arthrofibrosis in the joints is definitely multifactorial, but intense production of collagen seems to be the main factor. Most modern pharmacological methods concentrate on the regulation of collagen fiber production and reducing the inflammation. Inflammation from joint contractures stimulates the proliferation of activated cells that results in the production of extracellular matrix macromolecules to form fibrotic tissue that is deposited into the capsule, thereby resulting in fibrosis. Lack of unified classification scale is caused by relatively high variation of the functions fulfilled by particular joints and each treatment plan should be constructed individually. Quality of surgical treatment and physical therapy play a major role in both prevention and treatment of such complex condition as arthrofibrosis. Both iatrogenic mistakes and overly aggressive manual therapy are some of main factors increasing the risk of this pathological condition. Introducing properly conducted physical therapy treatment in the early stage is crucial to main the range of movement and preventing this significant problem.
Association between fecal levels of Short-Chain Fatty Acids and serum Pro- and Anti-Inflammatory Cytokines in patients with Inflammatory Bowel Disease.
Kaczmarczyk O, Dąbek-Drobny A, Woźniakiewicz M … +9 more , Paśko P, Dobrowolska-Iwanek J, Woźniakiewicz A, Targosz A, Ptak-Belowska A, Piątek-Guziewicz A, Wcisło K, Zagrodzki P, Zwolińska-Wcisło M
Folia Med Cracov · 2022 Jun · PMID 36088592 · Publisher ↗
INTRODUCTION: Inflammatory bowel disease (IBD) represents a group of chronic inflammatory disorders characterized by dysbiosis and altered short-chain fatty acid (SCFA) level. The association between individual SCFA leve...
INTRODUCTION: Inflammatory bowel disease (IBD) represents a group of chronic inflammatory disorders characterized by dysbiosis and altered short-chain fatty acid (SCFA) level. The association between individual SCFA levels and cytokine levels is unknown. OBJECTIVES: We aimed to determine the fecal SCFA levels in patients with IBD in relation to disease severity and the serum levels of pro- and anti-inflammatory cytokines. PATIENTS AND METHODS: The study included 61 patients with IBD (inactive, 22; active, 39) and 16 controls. Fecal levels of organic acids (acetic, lactic, propionic, butyric, isovaleric, isobutyric, and valeric), serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), IL-17, and IL-22, complete blood count and C-reactive protein (CRP) were measured. RESULTS: Patients with active IBD had reduced butyric, acetic, valeric, and isovaleric acid levels and elevated lactic acid levels in stool. Hemoglobin levels were positively correlated with the levels of acetic and butyric acids (R = 0.266 and R = 0.346, respectively; P <0.05). In addition, CRP levels were inversely correlated with butyric acid levels (R = -0.573; P <0.05). Higher serum TNF-α levels were observed in patients with active IBD compared with controls (6.64 pg/ml vs 2.05 pg/ml, P <0.05). No relationship was noted between the SCFA profile and cytokine levels. CONCLUSIONS: The study showed that determination of SCFA levels can be used to evaluate the activity of IBD. The relationship between individual SCFA and cytokine levels seems to be complex and requires further studies.
The 3D printed teeth models intended for hands-on practice in conservative dentistry.
Dobroś K, Hajto-Bryk J, Zarzecka J
Folia Med Cracov · 2022 Jun · PMID 36088591 · Publisher ↗
OBJECTIVES: Designing and printing out a 3D model of a mandible, including the teeth with replicated carious lesions, to be fitted into the Dental Patient Simulator. Students assessed the 3D teeth models against the extr...
OBJECTIVES: Designing and printing out a 3D model of a mandible, including the teeth with replicated carious lesions, to be fitted into the Dental Patient Simulator. Students assessed the 3D teeth models against the extracted teeth and the standard models, identifying specific restorative dentistry procedures where they might be applied as the teaching aids. METHODS: A 3D tooth model was printed out against a patient's Cone Beam Computed Tomography scan. The study was attended by 22, 5th-year students, who, having prior removed the caries, filled in the cavities of different classes and trepanned the pulp chamber in the 3D models, subsequently rating them against a questionnaire. RESULTS: Over 95% of students recommended introducing the 3D models into teaching conservative dentistry with endodontics at the pre-clinical stage to enhance manual skills in cavity preparation and filling. The replication of tissue hardness and anatomical characteristics in the 3D models was rated significantly higher, as compared to the standard ones (p <0.05). Over 90% of students also asserted that working on the 3D models would enhance their pulp chamber trepanation skills, and rated overall replication of the anatomical characteristics significantly higher, in comparison with the standard teeth models (p <0.05). CONCLUSIONS: In pre-clinical education, the 3D teeth models offer a viable alternative, as there is an appreciable potential for different types of teeth to be printed out, in full consideration of their anatomical diversity. Further design refinements in the 3D teeth models are required, though, particularly the ones regarding true-to-life replication of the soft tissues.
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