Klinicheskaia Meditsina[JOURNAL]
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200 papers
[Electrocardiographic aspects of morphogenesis of neuroleptic cardiopathy].
Volkov VP
Klin Med (Mosk) · 2016 · PMID 30290099
UNLABELLED: Neuroleptic cardiomyopathy (NCMP) is a consequence of cardiotoxic side effect of antipsychotic drugs. Changes of ECG associated with this condition are poorly known. AIM: To elucidate dynamics of ECG at diffe...
UNLABELLED: Neuroleptic cardiomyopathy (NCMP) is a consequence of cardiotoxic side effect of antipsychotic drugs. Changes of ECG associated with this condition are poorly known. AIM: To elucidate dynamics of ECG at different clinical stages of NCMP and evaluate its diagnostic value. Methods. We determined the frequency and informative values of 8 different ECG signs includingQTinterval corrected based at theBazettformula (QTc). Their informative value was estimated from the Kullback formula. The data obtained were analyzed by parametric and non-parametric statistics methods. RESULTS: Pathological changes of ECG parameters associated with NCM Preflect processes of structural rearrangement in the heart at different levels of its organization. The analysis of the available information showed that almost all ECG parameters have high diagnostic value listed in the following rank order (frequency/informativeness): rhythm disorder - 1/8, prolongation of the QTc interval - 4/3, conduction disorder - 2/2, diffuse muscular changes - 3/1, right heart overload - 5/6, left ventricular hypertrophy - 7-8/5, impaired electrical activity of myocardium - 7-8/5, deviation of the electrical axis to the left - 6/4. It seems appropriate to distinguish the following three maximally informative (and therefore most important) ECG signs indicative of developing NCMP: diffuse muscular changes, conduction disorder, and prolongation of the QTc interval. CONCLUSION: The analysis of the available information provides a new insight into dynamics of ECG signs associated with NCMP and permits to estimate the diagnostic value of pathological changes for its earlier detection.
[Tendencies in cardiovascular morbidity and mortality in the population of Siberia].
Gafarov VV, Gromova EA, Gagulin IV … +2 more , Panov DO, Gafarova AV
Klin Med (Mosk) · 2016 · PMID 30289679
AIM: To characterize differences in the risk of development (RD) of myocardial infarction (MI) and stroke during 16 years in an open Siberian population aged 25-64 years and suffering vital exhaustion (VE). MATERIALS AND...
AIM: To characterize differences in the risk of development (RD) of myocardial infarction (MI) and stroke during 16 years in an open Siberian population aged 25-64 years and suffering vital exhaustion (VE). MATERIALS AND METHODS: We examined a random representative sample of 657 men and 870 women from the Novosibirsk population in the framework of the WHO «MONICA-psychosocial» screening III program (1954). It included registration of socio-demographic data and cases of VE. A total of 15 episodes of MI and 35 strokes were documented in 30 women and 22 men. RESULTS: The level of VE in men was 66,8% (high in 14,6%), in women75,7% (high in 44,4%). RD of MI estimated from the relative risk (RR) in men with VE(RR=2) was higher than in women. It was higher in divorced women (RR=5,4) than in men (RR=4,7). RD of MI was higher in men with VE (OR=2,2 in subjects having elementary education, OR=3,7 in bachelors, OR = 7 in widowers;at the age from 45 to 54 years OR=3,8, at the age from 55 to 64 years OR=5,9) than in women. The overall RD of stroke in subjects of either sex with VE was not significantly different (OR=3,34 in women and 3,1). However, it was higher than in women in men with VE having partially completed secondary-level and elementary education RR=4.8), in divorced and widowed men (RR=3.8 and 3.6 respectively. CONCLUSION: The study showed that the prevalence of VE in the population aged 25-64yearsis higher than in other age groups and higher in women than in men. VE is a more reliable predictor of MI in men than in women; it is a predictor of stroke in either sexes.
[Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].
Mal'tseva NV, Laputenko TA, Gorbatovsky YA … +1 more , Lykova OF
Klin Med (Mosk) · 2016 · PMID 30289676
Infectioue endocarditis (IE) is frequently associated with the use of narcotic drugs, glucocorticosteroids, and cytostatics that are metabolized in the body by enzymes of the xenobiotic detoxification system (XDS). This...
Infectioue endocarditis (IE) is frequently associated with the use of narcotic drugs, glucocorticosteroids, and cytostatics that are metabolized in the body by enzymes of the xenobiotic detoxification system (XDS). This work was aimed at elucidating association between IE and mononucleotide polymorphisms of genes encoding XDS enzymes. 46 IE patients and 114 subjects without cardiovascular diseases (controls) underwent genotyping for polymorphic loci of cytochrome P450 1A1 gene I462V (CYP1A1), I105VandA114V gene of glutathione-S-transferase Pi1 (GSTP1) using allele-specific PCR. The study revealed association of CYP1A1 I462VandGSTP1 I105V with IE while IE proved unrelated to GSTP1 A114V polymorphism. Combination of homozygous variant I462I of the CYP1A1 gene and heterozygous variant I105V/ of the GSTP1 gene was associated with the 9-fold increase of the risk of IE in the subjects practicing intravenous druginjections or having congenital and acquired heart failure or implanted valve prostheses. These findings suggest the necessity of further studies on the role of XDS in pathogenesis of IE and other infectious diseases.
[Atheromatosis of arterial intima].
Titov VN, Rozhkova TA, Amelyushkina VA
Klin Med (Mosk) · 2016 · PMID 30289672
Phylogenetically late arterial intima of the elastic type contains no proteins for the transfer of ligandless oxidized low density lipoproteins (LDLP) for sedentary macrophages adsorbed on the matrix. Phylogenetically ea...
Phylogenetically late arterial intima of the elastic type contains no proteins for the transfer of ligandless oxidized low density lipoproteins (LDLP) for sedentary macrophages adsorbed on the matrix. Phylogenetically early cells realize the extracellular digestive reaction by releasing proteolytic enzymes (metalloproteinases) into intimal matrix that hydrolize matrix proteoglycans, adsorbed ligandless LDLP, detritus, and complete lysosomal hydrolysis of the most hydrophobic polyenic cholesterol esters (poly-ECS). Smooth muscle cells migrate from the middle muscular layer of the arterial wall, change their contractile phenotype to secretory one, and synthesize in situ de novomatrix proteoglycans. The arterial wall has three layers (monolayer endothelium, intimal media (smooth muscle cells), and adventitia) only in elastic type arteries. It is desirable to elucidate functional differences between phylogenetically early sedentarymacrophages and monocytes-macrophages of later origin and understand whether theydepends on specific features of activity of scavenger eceptors, CD36 translocases, expression of acid hydrolases synthesis for poly-ECS or realization of the extracellular digestion reaction. We believe that formation of atheromatous masses takes place in the matrix of arterial intima rather than in lysosomes taking into account limited possibilities for monocytes-macrophages to realize endocytosis of ligandless LDLP from the matrix. Given that atheromatosis is a syndrome of deficit of essential polyenic fatty acids (PFA) in the cells, intimal atheromatosisshould be regarded only as partial utilization of excess PFA in the matrix of elastic type arteries. At later stages of phylogenesis, intima was formed from media smooth muscle cells.
[Clinical significance of heart rhythm variability in patients with gastroesophageal reflux disease].
Maev IV, Yurenev GL, YurenevaTkhorzhevskaya TV
Klin Med (Mosk) · 2016 · PMID 30289671
Cardiac manifestations of gastroesophageal reflux disease (GERD) including retrosternal pain and cardiac rhythm disorders were often mentioned in early publications. However, classification of GERD adopted at the 2005 Mo...
Cardiac manifestations of gastroesophageal reflux disease (GERD) including retrosternal pain and cardiac rhythm disorders were often mentioned in early publications. However, classification of GERD adopted at the 2005 Montreal congress does not include such conditions. Non-coronarogenic pain in the thoracic cage is recognized to be a typical esophageal syndrome while the reflex spasm of coronary arteries and cardiac rhythm disorders associated with GERD should be regarded as manifestations of comorbidity of GERD and cardiovascular diseases. Arrhythmias occur in 30% of patients with GERD, but relevant therapeutic and preventive modalities are poorly developed. Nor are there reliable predictors of arrhythmias. An important role in their pathogenesis in patients with GERD is played bydisbalance of sympathetic and parasympathetic components of vegetative nervous system (VNS). One of the approaches to studying this issue is the analysis of heart rhythm variability (HRV). We consider basic principles of clinical interpretation of the results of HRV research that allow to evaluate the state of VNS and interaction of its components. Analysis of recent publications gives evidence that many HRV parameters depend not only on the balance between components of VNS as was believed by earlier authors (for the lack of their reciprocal relationship) but also on the activity of these components. Other modulating factors include the heart rate, respiratory pattern, intrathoracic pressure, and diastolic atrial extension. We report the results of HRV assessment in patients with GERD that illustrate heart rhythm rigidity and predominant disorders of activity of the parasympathetic component of VNS especially well apparent in patients with erosive reflux esophagitis. However, other authors demonstrate oppositely directed changes and the involvement of the sympathetic component. A possible cause of this discrepancy is factors other than VNS influencing HRV. It is concluded that analysis of HRV can be used to develop a method for the prevention of GERD-associated arrhythmia. The diagnostic value of such method is limited and requires new algorithms for data interpretation taking account of their multifactorial origin.
[Scientific legacy of I.V. Davydovsky - philosophical foundations of general pathology].
Tsimmernam YS, Dimov AS
Klin Med (Mosk) · 2016 · PMID 30289670
The vast empirical material on pathogenesis of diseases has thus far been accumulated. However, its systematization and philosophical interpretation have not been given due attention since the time of I.V. Davydovsky. Th...
The vast empirical material on pathogenesis of diseases has thus far been accumulated. However, its systematization and philosophical interpretation have not been given due attention since the time of I.V. Davydovsky. The value and topicality of I.V. Davydovsky’ ideas need a fresh view andfurther development in the context of knowledges of the XXI century. The analysis of the selected provisions of I.V. Davydovsky offered in the article will hopefully contribute to their introduction into applied medicine.
[Clinical rhetoric in the high school].
Odin VI
Klin Med (Mosk) · 2016 · PMID 30289669
Clinical rhetoric is a science concerned with consistent patterns of speech behavior in different situations of interaction with colleagues, patients, and specialists in various disciplines with a view to extending their...
Clinical rhetoric is a science concerned with consistent patterns of speech behavior in different situations of interaction with colleagues, patients, and specialists in various disciplines with a view to extending their practical applications for the enhancement of efficiency of meaningful contacts. The history of this science as a means of rational communication with patients and medical profession dates back to the times of Hippocrates. Its importance greatly increased under the present-day conditions of high-technology and therapeutically aggressive medicine. Clinical rhetoric is based on the principles of general rhetoric. A clinician must be prepared for he fruitful and constructive relations with a variety of partners including patients, healthy subjects, administrators, lawyers, businessmen, and colleagues. Four main peculiarities of clinical rhetoric are distinguished: any debate is possible only in the form of discussion, both the form and content of the opponent’s arguments should be treated with respect, the speaker must himself draw attention to the weak points of his theses, all discussions must have the form of a “captain council” in which the shipboy is the first and the captain the last to speak. Traditional forms of clinical discussion include counselling, doctor’s rounds, consilia, and demonstrations. Collective forms of stimulating creative thinking, such as brainstorming and foresight have especially good prospects. These approaches appear to be of special value for the solution of heuristic problems. Teaching clinical rhetoric should be initiated since term IV when students begin to understand the role of a doctor as a key figure in the organization of the diagnostic and therapeutic process. Further development of Hippocrates’ traditions of collective communication may significantly promote the intellectual return from clinical and scientific discussions in medicine.
[Case report of a combination of periodic disease and irritable bowel syndrome].
Pogromov AP, Mnatsakanyan MG, Kolosova KY
Klin Med (Mosk) · 2016 · PMID 30289668
The article reports a case of atypical picture of a combination of periodic disease and irritable bowel syndrome in a 52 year old patient.
The article reports a case of atypical picture of a combination of periodic disease and irritable bowel syndrome in a 52 year old patient.
[A rare case of oxalate nephropathy with acute renal injury].
Ustinova EE, Malov VI, Lareva NV
Klin Med (Mosk) · 2016 · PMID 30289667
OBJECTIVE: This case demonstrates the difficulty of diagnostics of oxalate nephropathy and possibility of development of acute kidney injury. SUMMARY: The paper describes a patient with oxalate nephropathy and acute kidn...
OBJECTIVE: This case demonstrates the difficulty of diagnostics of oxalate nephropathy and possibility of development of acute kidney injury. SUMMARY: The paper describes a patient with oxalate nephropathy and acute kidney injury. Specific features of oxalate diathesis are discussed as well as approaches to its diagnosis. Clinical peculiarities and diagnostic difficulties are described. CONCLUSIONS: Early diagnosis of oxalate nephropathy and treatment permits to improve prognosis.
[Myocardial infarction at the border of two centuries: demographic and social tendencies].
Garganeeva AA, Okrugin SA, Borel' KN … +2 more , Kuzheleva EA, Parshin EA
Klin Med (Mosk) · 2016 · PMID 30289666
The aim of the study was to compare the incidence, onset, and the course of acute myocardial infarction (AMI) among the population of Tomsk in 1984 and 2013. Materials and Methods: The study was based on the analytic dat...
The aim of the study was to compare the incidence, onset, and the course of acute myocardial infarction (AMI) among the population of Tomsk in 1984 and 2013. Materials and Methods: The study was based on the analytic database of the World Health Organization epidemiology program AMI Registry (RAMI). Epidemiology of AMI was studied among the urban population aged 20 years and older. A total of 739 and 983 AMI cases were analyzed in 1984 and 2013 respectively. Results: The proportion ofpatients older than 60 years significantly increased in the age structure of AMI patients during the study period. The occurrence of AMI with atypical clinical onset increased by three times; anamnestic background of AMI worsened; and the number of episodes with preinfarction angina increased. Analysis of the AMIpicture revealed an increase in the occurrence of Q (QS)-wave myocardial infarction and a significant rise in the frequency of complications; the frequency of chronic heart failure, cardiac arrhythmias, and recurrent AMI was especially high. Conclusion: An increase in the proportion of elderly and senile people in the age structure resulted in an aggravation of the diagnostic and prognostic features of AMI during the study period. Evidently, the existing situation requires optimization of medical assistance for patients of older age groups with emphasis on the development and the implementation of recommendations concerning the prediction, diagnosis, treatment, and rehabilitation of these patients.
[Results of application of a new method for the treatment of hallux valgus of the first toe].
Brizhan’ LK, Boichenko AV, Davydov DV … +5 more , Solomin LN, Kerimov AA, Sheyanova EY, Tyul'kin EO, Belokrylova MS
Klin Med (Mosk) · 2016 · PMID 30289665
BACKGROUND: The aim of the present article was to report our experience with the treatment of patients with hallux valgus and to perform comparative analysis of the results of the newly proposed and standard methods for...
BACKGROUND: The aim of the present article was to report our experience with the treatment of patients with hallux valgus and to perform comparative analysis of the results of the newly proposed and standard methods for its surgical correction. METHODS: The data on 70patients (101 feet) with hallux valgus that were operated on between 2011 and 2015 in St. Petersburg Hospital No 2 using the new and standard methods were analysed. The functional assessment (AOFAS score) and X-ray examination were performed preoperatively, 3 and 12 months after the procedure. Comparative analysis between patients undergoing surgical correction by the new and standard methods has been undertaken. RESULTS: We did not find any significant difference between the two groups in mean AOFAS score 12 months after surgery. Nevertheless, the function score of the patients treated by the newly proposed method (79.4±6.5 in 3 months) was significantly better than in those given the standard treatment (72.2±7.6 in 3 months). Mean intermetatarsal angle 12 months after surgery by standard and new methods was 9,7±0,7° and 8,6±0,7° (p<0.05), mean metatarsophalangeal angle 13,6±0,9° and 13,0±1,1° (p<0,05) respectively. CONCLUSION: According to the data obtained, the original method of hallux valgus surgical correction allows to improve its functional and x-ray results.
[Biliary reflux-gastritis: etiology, pathogenesis and modern principles of treatment].
Tel’nykh YV, Abgadzhava EZ, Kon’kov MY
Klin Med (Mosk) · 2016 · PMID 30289664
Objective. To study etiopathogenetic aspects of biliary reflux-gastritis (RG) and develop modern principles of its therapy depending on acidity of stomach contents, atrophy ofgastric mucosa, and Helicobacter pylori infec...
Objective. To study etiopathogenetic aspects of biliary reflux-gastritis (RG) and develop modern principles of its therapy depending on acidity of stomach contents, atrophy ofgastric mucosa, and Helicobacter pylori infection. Different pathogenetic mechanisms of RG are discussed with special reference to bile flow into the antrum as a result of duodenogastric reflux. It is shown that the use of de-nol and probiotic ProBiotic Complex for the treatment of biliary reflux-gastritis increases effectiveness of H. pylori eradicationby 18.2% and prevents the development of bowel dysbiosis.
[Peculiarities of the psychic state and quality of life in patients with duodenal ulcer in the context of chronomedicine].
Kolesnikov DB, Rapoport SI, Voznesenskaya LA … +1 more , Rasulov MI
Klin Med (Mosk) · 2016 · PMID 30289663
Most clinicians consider duodenum ulcer as a psychosomatic disease. Objective: To show the interdependence of this condition and mental disorders and their relation to disturbances of melatonin production . Materials and...
Most clinicians consider duodenum ulcer as a psychosomatic disease. Objective: To show the interdependence of this condition and mental disorders and their relation to disturbances of melatonin production . Materials and Methods: 15 patients with seasonal DU and 15 healthy subjects of the control group were examined during 3 years using laboratory, endoscopic, and standard psychodiagnostic methods. Results. It was found that all patients with exacerbation of DU experienced enhanced anxiety, reduced background mood, and impaired quality of life based on general health and mental health scoring scales. The circadian rhythm of melatonin production was markedly distorted throughout the observation period but especially during exacerbations of the disease. Conclusions. The results indicate a high degree of correlation between DU and mental disorders caused by impaired production of melatonin. It suggests common etiological mechanisms of DU and psychosomatic symptom complex.
[Differential diagnostics of febrile conditions in an emergency care clinic].
Budnevsky AV, Esaulenko IE, Grechkin VI … +1 more , Romashov BB
Klin Med (Mosk) · 2016 · PMID 30289662
We undertook the analysis of 157 cases of fever at the stages of polyclinic - admission department - hospital treatment for the purpose of elucidating the structure of febrile syndrome. Pneumonia developed in 45 patients...
We undertook the analysis of 157 cases of fever at the stages of polyclinic - admission department - hospital treatment for the purpose of elucidating the structure of febrile syndrome. Pneumonia developed in 45 patients, infectious endocarditis in 34, chronic alcoholic hepatitis in 21, rheumatoid arthritis (pseudoseptic variant) in 2, systemic lupus erythematosus in 1, polymyositis in 2, acute pyelonephritis (exacerbation of chronic pyelonephritis) in 15, tumours of different localization in 37 patients. We evaluated the informative value of some acute-phase blood characteristics obtained, results of X-ray and ultrasonic studies for early diagnostics of pneumonia and infectious endocarditis.
[The clinical significance of insulin resistance, impaired carbohydrate and lipid metabolism in the development of microcirculation pathology in patients with chronic heart failure and type 2 diabetes mellitus].
Statsenko ME, Turkina SV, Shilina NN … +1 more , Kosivtsova MA
Klin Med (Mosk) · 2016 · PMID 30289661
Patients with chronic heart failure and diabetes mellitus type 2 experience continuous progression of organ damage as a result of hemodynamic and metabolic disorders. An important role in pathogenesis of organ damage bel...
Patients with chronic heart failure and diabetes mellitus type 2 experience continuous progression of organ damage as a result of hemodynamic and metabolic disorders. An important role in pathogenesis of organ damage belongs to pathological types of microcirculation, endothelial dysfunction and insulin resistance. But the role of insulin resistance and its contribution to the formation of endothelial dysfunction and peculiarities of microcirculation in patients with chronic heart failure and type 2 diabetes mellitus is unknown. This study shows significant association between insulin resistance, disorders of carbohydrate and lipid metabolism, development of microcirculatory disturbances and endothelial dysfunction.
[Arterial hypertension as a risk factor of intra-atrial thrombosis in patients with atrial fibrillation of non-valvular etiology].
Grontkovskaya AV, Borovkov NN, Amineva NV
Klin Med (Mosk) · 2016 · PMID 30289660
UNLABELLED: The article considers the influence of arterial hypertension on the frequency of intra-atrial thrombosis in patients with atrial fibrillation (AF) of non-valvular etiology. MATERIALS AND METHODS: 38 patients...
UNLABELLED: The article considers the influence of arterial hypertension on the frequency of intra-atrial thrombosis in patients with atrial fibrillation (AF) of non-valvular etiology. MATERIALS AND METHODS: 38 patients were examined (26 men and 12 women) aged 35 to 75 years with documented AF. Paroxysmal AF was diagnosed in 10 patients (26.32%). The persistent and permanent forms of arrhythmia were revealed in 14 cases (36.84%). Stage II-III hypertensive disease (HD) was diagnosed in 27 patients (71.1%). The transthoracic and transesophageal echocardiography was performed with the use of ultrasonic devices such as Aloka-SSD-4000 ProSound (Japan) and PhilipsIE 33 (USA). RESULTS: The analysis of results of echocardiography (both transthoracic and transesophageal) made it possible to detect intra-atrial clots in 54,8% of the patients with AF of non-valvular etiology. Atrial cavity thrombosis was registered in 15 of the 22 cases (68,2%) among the patients with hypertension as a direct cause of AF or another concomitant pathology. Lower blood flow velocity from the left atrial appendage was registered in hypertensive patients compared to those without hypertension - 29.0 (4.2) and 35.4 respectively (8.1) mm/s (p = 0.038; Student's t-test). The reduction of the peak bloodflow velocity in the left atrial appendage was proportional to the increase of hypertension (R = -0,861; p <0,001; R - Spearman's coefficient). The frequency of intra-atrial thrombosis did not depend on the form of atrialfibrillation and duration of the arrhythmic anamnesis. CONCLUSION: Hypertension is an independent predictor of thromboembolic complications in atrial fibrillation of non-valvular etiology.
[Alterations of physiological rhythms in neurodegenerative disorders: problems and prospects of light therapy].
Zueva MV, Tsapenko IV, Manko OM … +1 more , Smoleevsky AE
Klin Med (Mosk) · 2016 · PMID 30289659
This review provides an outline of circadian disorders associated with neurodegenerative diseases of the brain in the elderly, including Alzheimer's (AD) and Parkinson's diseases (PD). Since light is one of the most powe...
This review provides an outline of circadian disorders associated with neurodegenerative diseases of the brain in the elderly, including Alzheimer's (AD) and Parkinson's diseases (PD). Since light is one of the most powerful environmental cues synchronizing physiological rhythms, exposure to bright light is often used to treat sleep disorders, behavior of patients with severe dementia, gait, and other functions disordered in CNS pathologies. Photobiomodulation effects of the low-energy laser and LED radiation is also considered as a potential tool for the rehabilitation of patients with various pathologies. It yielded positive results in the treatment of both PD and AD. An external factor that can exacerbate a course of neurodegenerative diseases is light pollution. Irrational artificial lighting can cause jet lag, affect visual and cognitive functions. The review also summarizes the current understanding of fractal dynamics of physiological rhythms in healthy subjects (including brain activity) and their reduced complexity in pathological conditions. The loss of multiscale complexity of brain electrical activity has been documented for patients with AD, PD, epilepsy, and schizophrenia. It is thought to reflect fundamental changes in the regulation of the body's circadian rhythms. Recently, M.V Zueva proposed and theoretically substantiated the hypothesis that allows taking another look at the prospects for the use of light stimulation. It is expected that the use of stimuli with fractal structure can help to restore the retina and brain’s functions in neurodegenerative diseases by reactivation of neuronal plasticity and be an innovative method for the treatment of neurodegenerative disorders.
[The possibilities and limits of modern bronchodilating therapy for COPD].
Sinopal’nikov AI, Leshenko IV
Klin Med (Mosk) · 2016 · PMID 30289658
This article is a critical review designed to assess the efficacy and safety of modern bronchodilating therapy for COPD patients.
This article is a critical review designed to assess the efficacy and safety of modern bronchodilating therapy for COPD patients.
[Iron deficiency syndromes associated with diseases of the gastrointestinal tract: state-of-the-art and new prospects for treatment].
Stuklov NI
Klin Med (Mosk) · 2016 · PMID 30289657
Organs of the gastrointestinal tract (GIT) are essential for iron metabolism and hematopoiesis regulation. Iron deficiency is accompanied by a large number of diseases of GIT. The article discusses the problem of diagnos...
Organs of the gastrointestinal tract (GIT) are essential for iron metabolism and hematopoiesis regulation. Iron deficiency is accompanied by a large number of diseases of GIT. The article discusses the problem of diagnosis and treatment of anemia, It describes mechanisms of development of anemia associated with bleeding, malabsorption, and chronic inflammation. It provides current data on the use of oral and intravenous iron-containing drugs, discusses advantages of the new oral form of sucrosomial iron for the treatment of anemia associated with GIT diseases.
[Disorders of carbohydrate metabolism in chronic obstructive pulmonary disease].
Kobylyansky VI
Klin Med (Mosk) · 2016 · PMID 30289656
The literature data and our own experience suggest that chronic obstructive pulmonary disease can be an important risk factor of type 2 diabetes mellitus. The relationship between these two condition is virtually unexplo...
The literature data and our own experience suggest that chronic obstructive pulmonary disease can be an important risk factor of type 2 diabetes mellitus. The relationship between these two condition is virtually unexplored and pathogenteic mechanisms behind it remain unclear. There are reasons to attribute an important role to insulin resistance as one of the leading mechanisms. It is in the focus of the present work.
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