Pérez-Granda MJ, Bouza E, Barrio-Gutiérrez JM
… +8 more, Machado M, Estevez A, Cuerpo G, Hortal J, Muñoz P, González-Pinto Á, Valerio M, Cardiovascular Infection Study Group
Rev Esp Quimioter
· 2025 Sep · PMID 40432453
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BACKGROUND: Postsurgical mediastinitis (PSM) is a serious and potentially life-threatening complication of Major Heart Surgery (MHS). Data on the evolution of the incidence of PSM after MHS in large series of operated pa...BACKGROUND: Postsurgical mediastinitis (PSM) is a serious and potentially life-threatening complication of Major Heart Surgery (MHS). Data on the evolution of the incidence of PSM after MHS in large series of operated patients in recent years are scarce. The aim of our study was to evaluate the trend of incidence, microbial etiology, and associated mortality of PSM at a referral MHS unit in the last 12 years. MATERIAL AND METHODS: The study was conducted at a tertiary hospital in Madrid, Spain. We carried out a retrospective and cross-sectional study that included all patients who underwent CCM and developed MPQ between January 2012 and December 2023 at our institution. It was conducted at a tertiary hospital in Madrid, Spain. We carried out a retrospective and cross-sectional study that included all patients who underwent CCM and developed MPQ between January 2012 and December 2023 at our institution. RESULTS: During the 12-year study period, a total of 5,584 patients underwent MHS at our institution. The incidence rate of PSM varied yearly between 1.16 and 2.34 episodes/100 surgical procedures. Overall, the 89 patients with PSM were analyzed (92 different episodes). Their median age was 67 years (IQR 56-75) and most of them were male (63%). Their median Euroscore was 7 (IQR 5-9.5). Main type of heart surgery in patients with PSM was: coronary artery bypass graft in 37% and valve replacement in 32.6%. The more frequent causative microorganisms were: Gram-positive bacteria (59.0%), Gram-negative bacteria (32.4%), fungi (7.6%) and others (1%). Overall, 22 patients died (24.7%). CONCLUSIONS: The incidence of PSM has remained stable and below 2.5% in the last 12 years in our institution, but it continues to be an entity associated with high morbidity and mortality and long hospital stays.
de Rafael-González E, Cabañas-Morafraile J, Serrano-Martín L
… +14 more, Julián-Jiménez A, Torres-Fernández M, Chaves-Prieto E, Morell-Jurado L, López-Forero WE, Calafell-Mas MF, Cordero ÁT, Asensio-Nieto MR, Nieto-Rojas I, Rubio-Díaz R, Heredero-Gálvez E, Lorenzo-Lozano MC, Canabal-Berlanga R, en nombre del grupo URGEN-LABQMIC del CHUT del Instituto de Investigación Sanitaria de Castilla La Mancha (IDISCAM)
Rev Esp Quimioter
· 2025 May · PMID 40432452
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OBJECTIVES: To analyze and compare the accuracy of midregional proadrenomedullin (MR-proADM) to predict poor clinical outcome (understood as progression to septic shock or admission to the Critical Care Unit -CCU-) and 3...OBJECTIVES: To analyze and compare the accuracy of midregional proadrenomedullin (MR-proADM) to predict poor clinical outcome (understood as progression to septic shock or admission to the Critical Care Unit -CCU-) and 30-day mortality in adult patients seen for suspected infection in the Emergency Department (ED). We also compared their performance with other biomarkers (C-reactive protein -CRP-, procalcitonin -PCT-, lactate and leukocyte count) and clinical scales widely used in routine practice (qSOFA, SRIS, NEWS-2). METHODS: A prospective, observational and analytical study was carried out on adult patients who were treated in an ED with the clinical diagnosis of an infectious process. Follow-up was carried out for 30 days. The main outcome was a composite measure that included progression to septic shock or admission to the CCU and 30-day mortality. The predictive ability was analyzed with the area under the curve (AUC) of the receiver operating characteristic (ROC) and the values of sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of MR-proADM, PCR, PCT, lactate, leukocyte count and the clinical scales. RESULTS: 214 patients were included, of whom 31 (14.5%) fulfilled the combined variable. The mean age was 68.6 (SD 20.75) years, 55.1% (118) were men. The MR-proADM concentration achieved the best AUC-ROC of 0.920 (95% CI: 0.850-0.989) compared to the other biomarkers and clinical scales. With a cut-off point (Cp) according to the Youden index > 2.105 nmol/L, a Se: 68%, Es: 98% and NPV: 97% were obtained. The NEWS-2 scale ≥ 5 achieves an AUC-ROC of 0.733 (95% CI: 0.630-0.835) with a Se: 87%, Es: 55% and NPV: 96%. The mixed model (MR-proADM ≥2.1 nmol/l + NEWS-2 ≥5) improved the AUC-ROC to 0.849 (95% CI: 0.782-0.915) and Se: 68%, Es: 98%, PPV: 74% and NPV: 88%. CONCLUSIONS: In adult patients attended with clinical suspicion of infection in the ED, MR-proADM presents a high ability to predict poor clinical evolution (progression to septic shock or ICU admission) and 30-day mortality and performs better than PCT, lactate, CRP, leukocyte count and the clinical scales qSOFA, SRIS, NEWS-2. The combined model (MR-proADM ≥2.1 nmol/L + NEWS-2 ≥5) improves prediction of both MR-proADM and clinical scales.
Zas-García MI, Fernández-Carreira JM, Rodríguez-Prida J
… +6 more, Blanco-Suárez A, Álvarez-Pérez M, Rubio-Sanz J, Castelo-Alvárez E, González-Fernández D, Rubio-Alfonso T
Rev Esp Quimioter
· 2025 May · PMID 40432450
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OBJECTIVE: To evaluate how antimicrobial consumption was influenced by increasing the frequency of meetings in which the Antimicrobial Stewardship Program (ASP) team conducted prospective audit and feedback (PAF). MATERI...OBJECTIVE: To evaluate how antimicrobial consumption was influenced by increasing the frequency of meetings in which the Antimicrobial Stewardship Program (ASP) team conducted prospective audit and feedback (PAF). MATERIALS AND METHODS: Retrospective cohort study comparing consumption in DDD per 1000 beds-day and DDD per 1000 admissions across groups of anti-infectives, antibacterial groups, agents against methicillin-susceptible (anti-MSSA agents)/agents against methicillin-resistant (anti-MRSA agents), antibiotics targeting sensitive Gram-negative bacteria/antibiotics targeting resistant Gram-negative bacteria and antimicrobial agents, during two comparative periods of ASP activity (2 weekly meetings in 2023 versus 1 weekly meeting in 2022). RESULTS: Comparing 2023 to 2022: antibacterials for systemic use consumption increased in DDD per 1000 beds-day (+0.13%) and decreased in DDD per 1000 admissions (-3.55 %); consumption in DDD per 1000 beds-day and DDD per 1000 admissions increased for penicillins, glycopeptides and aminoglycosides while it decreased for cephalosporins and carbapenems, quinolones use increased per beds-days but decreased per admissions; regarding anti-MSSA and anti-MRSA agents, consumption of cefazolin, cloxacillin, vancomycin and daptomycin increased in DDD per 1000 beds-day and DDD per 1000 admissions, linezolid consumption increased per beds-day but decreased per admissions; for antibiotics targeting sensitive Gram-negative bacteria and antibiotics targeting resistant Gram-negative bacteria, consumption of amoxicillin-clavulanate, piperacillin-tazobactam, aminoglycosides, ceftazidime, cefepime and polymyxins increased per DDD/1000 bed-days and DDD per 1000 admissions, carbapenems consumption decreased per bed-days and admissions. CONCLUSIONS: The increase in the frequency of meetings seems to be related to better use of antimicrobials in our center.
Iglesias-Varea J, Fernández-Ruiz M, Domínguez L
… +6 more, Boán J, Aparicio-Minguijón E, Terrón A, Asín MAP, Aguado JM, López-Medrano F
Rev Esp Quimioter
· 2025 May · PMID 40432449
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INTRODUCTION: Infective endocarditis (IE) is a complex condition associated with high morbidity and mortality. The creation of multidisciplinary teams (endocarditis team) has been shown to improve its management and prog...INTRODUCTION: Infective endocarditis (IE) is a complex condition associated with high morbidity and mortality. The creation of multidisciplinary teams (endocarditis team) has been shown to improve its management and prognosis. We analysed the impact of the formal implementation of a multidisciplinary IE committee (coIE) in a tertiary care hospital. METHODS: Single-centre quasi-experimental study comparing two periods: before (2010-2015) and after (2017-2021) the implementation of the coIE. The coIE met weekly (and on demand when necessary) to make decisions regarding medical and surgical management in patients with definite or possible IE, following a protocol based on international guidelines. RESULTS: We included 92 and 97 patients in the pre- and post-intervention periods, respectively. Demographic characteristics, predisposing factors, and types of IE were similar. No significant differences were observed in the proportion of patients with surgical indication who underwent surgery (30.2 % vs 39.1 %, respectively; p = 0.317), in-hospital mortality (27.2 % vs 34.0 %; p = 0.308), or one-year mortality (32.6 % vs 45.4 %; p = 0.073). The median (interquartile range) time from diagnosis to surgery decreased in the post-intervention period (11.5 [6.3-25.3] vs 7 [3-10] days; p = 0.026). The diagnosis of embolic events was more frequent in this period (46.7 % vs 58.8 %; p = 0.098). CONCLUSIONS: Although we did not observe a significant impact on mortality among patients with definite IE after the implementation of an endocarditis team, we noted a favourable trend in intermediate indicators of healthcare quality.
García CG, Contreras-Macías E, Naranjo-Pérez GA
… +1 more, Morillo-Verdugo R
Rev Esp Quimioter
· 2025 May · PMID 40432448
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INTRODUCTION: HIV is now considered a chronic disease due to advances in antiretroviral therapy (ART), which have improved survival but have also increased both comorbidities and polypharmacy. This underscores the need f...INTRODUCTION: HIV is now considered a chronic disease due to advances in antiretroviral therapy (ART), which have improved survival but have also increased both comorbidities and polypharmacy. This underscores the need for personalized care strategies such as the Capacity-Motivation-Opportunity (CMO) model and patient stratification tools. This study aimed to identify the discrepancy between patient-perceived and actual care complexity in HIV-positive patients on ART, as assessed by a stratification tool. METHODS: A retrospective, observational study at Valme Hospital (April-June 2024) included HIV-positive patients aged over 18 years on stable ART, excluding clinical trial participants. Data collected included age, sex, route of HIV acquisition, viral load, CD4 count, AIDS stage, comorbidities, polypharmacy and the Medication Regimen Complexity Index (MRCI). Perceived complexity was assessed using a visual analogue scale, whereas complexity according to the stratification tool was calculated with the variables of the CMO model. RESULTS: A total of 411 participants with a median age of 55 years were included, of whom 72.5 % had comorbidities, primarily cardiovascular. The median MRCI score was 8, with 85.4 % of patients were classified at stratification level 3, while 74.9 % reported low perceived healthcare complexity. Concordance between stratification and perceived complexity was weak. Significant associations were observed between perceived complexity and AIDS stage, extensive polypharmacy, and stratification levels. CONCLUSIONS: This study emphasises integrating objective assessments and patient perspectives to improve healthcare evaluation and patient-centered care.
Álvarez DM, García-Iglesias J, Rojas-Chicote C
… +5 more, Ruiz-Tornero AM, Mozo-Martín MR, Barrios-Escudero V, Rodríguez-Barrientos R, working group of the Residential Care Unit of the Community of Madrid (Addenda)
Rev Esp Quimioter
· 2025 May · PMID 40343744
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INTRODUCTION: Invasive pneumococcal disease is the most severe form of pneumococcal disease, with a high incidence rate that is associated with age and the existence of risk factors. The Residential Care Units (RCU) of t...INTRODUCTION: Invasive pneumococcal disease is the most severe form of pneumococcal disease, with a high incidence rate that is associated with age and the existence of risk factors. The Residential Care Units (RCU) of the Community of Madrid have been designed with the primary objective of improving the quality and safety of care for institutionalised patients. The aim of the study was to describe pneumococcal vaccination coverage and administration periods in institutionalised patients, as well as to analyse the possible association of different variables with vaccination status. MATERIALS AND METHODS: A retrospective observational study was conducted on institutionalised patients with an indicated vaccination who were in active status in their electronic health records as of May 2024. The study variables were age, sex, type of centre, Barthel Index, comorbidities, number of pneumococcal vaccine doses, and date of vaccination. A logistic regression model was used to assess the association of the variables age, sex, and Barthel Index with vaccination status. RESULTS: The total number of patients in the study population was 40,660. A total of 32,436 doses of pneumococcal vaccine were administered. Pneumococcal vaccination coverage was found to be 81.10% in centres for the elderly and 71.36% in centres for the disabled. Sex-adjusted variables associated with vaccination were age (OR:1.30; 95% CI: 1.12-1.50) in patients with older age and Barthel Index (OR: 1.87; 95% CI: 1.68-2.08) in patients with total dependency. CONCLUSIONS: The establishment of the RCUs has improved vaccination coverage. Moreover, adequate vaccination is associated with older age and a higher level of dependency. Strategies must be implemented to increase vaccination rates among both institutionalised patients and adults in the general population.
Rev Esp Quimioter
· 2025 Apr · PMID 40237636
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INTRODUCTION: Advances in antiretroviral therapy (ARV) have improved the life expectancy of people living with HIV (PLWH), shifting the focus to quality of life (QoL). However, aging, polypharmacy, and comorbidities pose...INTRODUCTION: Advances in antiretroviral therapy (ARV) have improved the life expectancy of people living with HIV (PLWH), shifting the focus to quality of life (QoL). However, aging, polypharmacy, and comorbidities pose challenges. This study aimed to evaluate the evolution of QoL over five years and identify associated sociodemographic, clinical, and pharmacotherapeutic factors. METHODS: A single-center retrospective observational study was conducted in PLWH attending a tertiary hospital outpatient pharmacy. QoL was assessed using the EQ-5D-5L questionnaire. Sociodemographic, clinical, and pharmacotherapeutic variables-including age, polypharmacy, comorbidities, and Medication Regimen Complexity Index (MRCI)-were analyzed. Multivariate logistic regression identified predictors of good QoL, defined as a Visual Analogue Scale (VAS) score ≥76. RESULTS: A total of 437 PLWH were included with median age 52 years. The participants were majority male (82.8%). Throughout the study, mean VAS scores remained stable, with 63.7-73.4% of participants reporting good QoL each year. The most frequently reported issues were related to mobility (8.9%), pain/discomfort (5.1%), and anxiety/depression (3.0%). Multivariate analysis showed that advanced age (OR: 1.55, 95%CI: 1.14-2.11), polypharmacy (OR: 1.87, 95%CI: 1.35-2.59), comorbidities (OR: 2.13, 95%CI: 1.76-2.89), and socioeconomic problems (OR: 2.47, 95%CI: 1.44-4.21) were significantly associated with lower QoL. CONCLUSION: Aging, polypharmacy, and socioeconomic disparities significantly impact QoL in PLWH. Integrating QoL assessments into routine care and addressing these factors through comprehensive management strategies could enhance long-term well-being.
Rev Esp Quimioter
· 2025 Apr · PMID 40208642
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INTRODUCTION: An observational study is presented on a community outbreak of parvovirus B19 (PVB19) infection that occurred between January and July 2024 in Mallorca. METHODS: PVB19 infection was diagnosed by serology (I...INTRODUCTION: An observational study is presented on a community outbreak of parvovirus B19 (PVB19) infection that occurred between January and July 2024 in Mallorca. METHODS: PVB19 infection was diagnosed by serology (IgM) and specific PCR. RESULTS: A total of 151 patients were diagnosed. Of these, 63 (41.7%) were <15 years old. The age groups with the highest number of cases were 5-10 years (19.8%) and 30-45 years (33.7%). Overall, 33.1% were male and 66.9% female, with age-related differences; among adults, 81.9% were female. The most frequent pathologies in the child population were fever, rash and petechiae, while in adults, fever and arthralgia predominated. Among the women, 8 were pregnant (11.1%) and 4 had fetal involvement. In addition to serum, PVB19 was detected in 10 pharyngeal swabs, 6 skin swabs, 3 cerebrospinal fluid (CSF) samples, and 1 amniotic fluid sample. Specific IgM was detected in 98.4% of cases, along with cross-reactions with Epstein-Barr virus (69.5%) and mumps virus (42.8%), mainly in adults. In 6 cases, positive IgM was detected to PVB19, Epstein-Barr virus and mumps were simultaneously detected (4 adults and 2 children). PCR was positive in 95.4% of all samples and in 94.6% of serum samples. CONCLUSIONS: The specific diagnosis of PVB19 infection should be based not only on clinical findings but also on serological detection (IgM) and genomic detection (PCR).
Arnaiz de Las Revillas F, Martín-López J, Heras-Vicario M
… +6 more, Briz Del Blanco M, Armiñanzas-Castillo C, Gutiérrez-Cuadra M, Runza-Buznego P, Parra-Fariñas R, Fariñas-Álvarez MC
Rev Esp Quimioter
· 2025 Apr · PMID 40192708
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García-Sangenís A, Raynal-Floriano F, López-Valcárcel BG
… +3 more, Vallejo-Torres L, Llor C, HAPPY PATIENT Study Group
Rev Esp Quimioter
· 2025 Mar · PMID 40145525
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OBJECTIVE: To evaluate the impact of a multifaceted antimicrobial stewardship intervention on potentially unnecessary antibiotic prescribing. MATERIAL AND METHODS: Before and after quality control study carried out in th...OBJECTIVE: To evaluate the impact of a multifaceted antimicrobial stewardship intervention on potentially unnecessary antibiotic prescribing. MATERIAL AND METHODS: Before and after quality control study carried out in three different settingsgeneral practice, out-of-hours services, and nursing homesin Spain. Healthcare professionals (both doctors and nurses) self-registered common infections using a specific template for each setting before (2022) and after (2023) receiving a 5-hour intervention on prudent antibiotic use. RESULTS: Eighty-nine professionals participated in the first registration (48 in general practice, 23 in out-of-hours services, and 15 in nursing homes), with 71 (79.8%) completing the intervention and second registration. Potentially unnecessary antibiotic prescriptions were 68.5%, 41.7%, and 77.7% in the first registration, respectively, and 61.4%, 34.8%, and 86.8% after the intervention, showing reductions of 10.4% in general practice and 16.5% in out-of-hours services, and an 11.7% increase in nursing homes, albeit without statistically significant differences. CONCLUSIONS: The study found that this intervention slightly improved antibiotic use, with minimal impact, but worsened in nursing homes.
Rodriguez-Leal CM, González-Corralejo C, Candel FJ
… +2 more, Salavert M, collaborative authors, members of the Study Group of Infections in Critically Ill Patients - Spanish Society of Clinical Microbiology and Infectious Diseases (GEIPC-SEIMC), and medical societies represented in 6th edition of Pneumonia Day (Addenda)
Rev Esp Quimioter
· 2025 Mar · PMID 40145524
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Pneumonia is the leading cause of death from infection in the developed world. In recent years, researchers and healthcare professionals have worked extensively to reduce this burden. Prevention is better than cure, and...Pneumonia is the leading cause of death from infection in the developed world. In recent years, researchers and healthcare professionals have worked extensively to reduce this burden. Prevention is better than cure, and significant advances have been made in areas such as vaccination and the prevention of nosocomial pneumonia in intensive care units. Comprehensive surveillance programmes and new diagnostic methods have been developed to assess trends in this disease and to identify the infectious agents involved. Clinical presentation can be challenging in elderly patients or those with certain comorbidities, prompting new studies in these populations to address these issues. Correct and early management of severe community-acquired pneumonia represents a major opportunity to reduce its associated mortality. Although fungal pathogens are an uncommon cause of lung infection, they are associated with high morbidity and mortality, highlighting the need for new approaches. Finally, new drugs are available for the treatment of pneumonia, and a thorough understanding of them is key to ensuring their correct use, particularly to combat multi-resistance. To provide an update on these points, a multidisciplinary team of Spanish experts convened at the Sixth Annual Meeting of Pneumonia Day, under the scientific sponsorship of GEIPC-SEIMC. This paper reflects the information shared at this meeting, offering the latest insights on these topics and supporting a holistic approach to pneumonia management.
Rodríguez-Villodres Á, Hoffmann-Álvarez MV, Camacho-Martínez P
… +1 more, Lepe JA
Rev Esp Quimioter
· 2025 May · PMID 40080405
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Human infections by are increasing in recent years. However, due to the lack of clinical susceptibility/resistance breakpoints, antimicrobial treatment is complex. Business Intelligence (BI) is a tool that allows to rec...Human infections by are increasing in recent years. However, due to the lack of clinical susceptibility/resistance breakpoints, antimicrobial treatment is complex. Business Intelligence (BI) is a tool that allows to record and analyze large amounts of data in a very short time. The aim of this study was to analyze a cohort of patients with infections focusing on how BI can help guide empirical antimicrobial therapy Demographic, clinical, and microbiological data about infections were recovered. Then, MIC of several antibiotics was automatically calculated through the BI. Thirteen infections were identified. The lowest MICs were for carbapenem, aminoglycoside, fluoroquinolones, and tetracyclines. The EUCAST PK-PD (non-species related) breakpoints showed that only piperacillin/tazobactam, imipenem and meropenem would be appropriate treatments to use empirically. In conclusion, BI systems have great potential to optimize the empirical antibiotic treatment in these types of infections.
Asensi-Diez R, Ballesteros-Fernández Á, Rouco M
… +2 more, Tortajada-Goitia B, Linares-Alarcón A
Rev Esp Quimioter
· 2025 May · PMID 40059630
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INTRODUCTION: To analyse the concordance between theoretical and actual stratification of people living with HIV infection attending a pharmaceutical care outpatient clinic in a tertiary regional hospital. MATERIAL AND M...INTRODUCTION: To analyse the concordance between theoretical and actual stratification of people living with HIV infection attending a pharmaceutical care outpatient clinic in a tertiary regional hospital. MATERIAL AND METHODS: Observational, retrospective, analytical, cross-sectional and single-centre study in people living with HIV infection. Study period: April 2024. Inclusion criteria: patients with HIV infection aged over 18 years who had been receiving active antiretroviral therapy (ART) for at least two years prior to inclusion. The 2022 version of the pharmaceutical care stratification model for people living with HIV infection was used. Reliability was evaluated from a qualitative perspective using Cohen's Kappa coefficient. RESULTS: Of the 199 patients attended during the study period, 100 were consecutively selected, of whom 93 were ultimately stratified. Men accounted for 77.41% of the cohort, with a mean age of 47.81 ± 12.53 years. The obtained stratification percentages were: Priority 1: 7.52%; Priority 2: 26.88%; Priority 3: 65.59%. Quantitative analysis of concordance between the models yielded a Cohen Kappa value of K=0.866. CONCLUSIONS: There is a good concordance between the distribution percentages of the theoretical stratification and the actual one obtained in our study.
Gotor-Rivera A, de Jorge-Huerta L, Silva JT
… +11 more, Fernández-Ruiz M, Rodríguez-Goncer I, Pérez-Jacoiste Asín MA, Ruiz-Merlo T, Heredia-Mena C, González-Monte E, Polanco N, San-Juan R, Andrés A, Aguado JM, López-Medrano F
Rev Esp Quimioter
· 2025 May · PMID 40042868
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INTRODUCTION: The increased risk of tuberculosis (TB) reactivation in solid organ transplant recipients supports the recommendation of screening for latent tuberculosis infection (LTBI). Adherence to available screening...INTRODUCTION: The increased risk of tuberculosis (TB) reactivation in solid organ transplant recipients supports the recommendation of screening for latent tuberculosis infection (LTBI). Adherence to available screening tests has not been studied in the kidney transplant (KT) population. We aimed to assess screening compliance within the ATALANTA-DOS population study. METHODS: ATALANTA-DOS studied an intervention bundle aimed at preventing infection in KT recipients. We compared LTBI screening rates between the pre-intervention (February 2016 - September 2017) and intervention (February 2018 - September 2019) cohorts and evaluated adherence rates between the interferon-gamma release assay (IGRA) and the tuberculin skin test (TST). RESULTS: A total of 307 KT recipients were included (155 in the pre-intervention cohort; 148 in the intervention cohort). A systematic assessment of screening compliance by an infectious disease specialist on day +30 post-KT improved LTBI screening adherence (82.6% [114/138] vs 1.3% [2/155]; p-value <0.001). In the intervention cohort, compliance was higher with IGRA (83.3% [52/62]) than with TST (68.1% [49/72]). Two cases of LTBI were detected in the pre-intervention cohort and five in the intervention cohort (4.4% [5/114]). All patients completed LTBI treatment after ruling out active TB. No cases of active TB were identified during follow-up. CONCLUSIONS: Systematic evaluation of LTBI screening compliance significantly increased screening completion rates among KT recipients. IGRA-based strategies increased screening compliance, supporting their implementation over TST for LTBI screening among KT recipients. Increased adherence would allow a more targeted and effective treatment of LTBI.