Miyabe R, Higaki A, Kurokawa K
… +13 more, Nishikawa T, Horie R, Nakao Y, Fujisawa T, Akazawa Y, Miyoshi T, Kawakami H, Higashi H, Tamaki S, Nishimura K, Inoue K, Ikeda S, Yamaguchi O
Am Heart J Plus
· 2026 Jun · PMID 42180597
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This study investigated the correlation between estimated plasma volume status (ePVS), calculated from hematocrit, and the extracellular water-to-total body water (ECW/TBW) ratio measured by bioelectrical impedance analy...This study investigated the correlation between estimated plasma volume status (ePVS), calculated from hematocrit, and the extracellular water-to-total body water (ECW/TBW) ratio measured by bioelectrical impedance analysis in 851 cardiovascular patients. We observed a significant positive correlation between ePVS and ECW/TBW (ρ = 0.491, < 0.01). Notably, ECW/TBW demonstrated superior performance in identifying elevated B-type natriuretic peptide levels compared to ePVS (AUC: 0.84 [95% CI: 0.81-0.87] vs. 0.75 [95% CI: 0.71-0.80], < 0.01), suggesting that BIA-derived indices may more accurately reflect cardiac congestion than formula-based plasma volume estimates.
Shariatnia S, Rajabi A, Ziaratban M
… +2 more, Salehi A, Vakili M
Cardiol Res Pract
· 2026 · PMID 42170530
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BACKGROUND: Coronary artery disease (CAD) is recognized as an inflammatory condition and remains a leading cause of morbidity and mortality worldwide. Cardiovascular disease (CVD), more broadly, is a major contributor to...BACKGROUND: Coronary artery disease (CAD) is recognized as an inflammatory condition and remains a leading cause of morbidity and mortality worldwide. Cardiovascular disease (CVD), more broadly, is a major contributor to global death and disability. This study aimed to compare the diagnostic performance of various noninvasive techniques for detecting CAD. METHODS: A cross-sectional study was conducted involving 758 participants, including 508 patients diagnosed with CAD and 250 without the disease. The diagnostic performance of two machine learning models-artificial neural networks (ANNs) and support vector machines (SVMs)-was evaluated. The classification models were assessed using receiver operating characteristic (ROC) curves, sensitivity, specificity, and overall accuracy. RESULTS: The study included a total of 758 participants. Among them, 250 individuals (33.6% male and 66.4% female) were diagnosed as non-CAD cases, while 508 participants (64% male, 36% female) were identified as having CAD. The area under the ROC curve (AUC) for CAD prediction was 0.752 (95% CI: 0.682-0.823) using the ANN model and 0.793 (95% CI: 0.733-0.853) using the SVM model. A statistically significant difference was observed between the performance of the two models in predicting CAD ( = 0.03), with the SVM model demonstrating superior predictive performance (AUC = 0.793, 95% CI: 0.733-0.853). CONCLUSIONS: SVMs demonstrated superior performance compared to ANNs in predicting the risk of CAD using simple clinical predictors.
Borghei Y, Gholami-Chaboki B, Goli N
… +2 more, Baharvand F, Salari A
Cardiol Res Pract
· 2026 · PMID 42170529
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BACKGROUND: Acute myocardial infarction (AMI) initiates an inflammatory response essential for cardiac repair. Several novel inflammatory markers have been identified as indicators of systemic inflammation, including the...BACKGROUND: Acute myocardial infarction (AMI) initiates an inflammatory response essential for cardiac repair. Several novel inflammatory markers have been identified as indicators of systemic inflammation, including the systemic immune-inflammation index (SII). This study aimed to evaluate the relationship between SII levels and readmission rates in AMI patients. METHODS: This retrospective cohort study analyzed 1147 AMI patients admitted between 2019 and 2021. The optimal SII cutoff was determined as 694.3 × 10/L, categorizing patients into high SII (≥ 694.3) and low SII (< 694.3) groups. The association between SII levels and readmission risk was assessed using a logistic regression model. RESULTS: Over 4 years, 454 patients were readmitted, with higher readmission rates (34.4%) observed in the high SII group. Statistically significant differences were noted in primary outcomes, with higher SII patients experiencing increased incidence of major adverse cardiovascular events (MACEs) ( < 0.05). The Cox proportional hazards model indicated that individuals with prior CABG had a 40% higher risk of readmission. CONCLUSION: Although patients with high SII demonstrated higher hospital readmission rates, primarily due to recurrent MI, no statistically significant association was observed.
Khasnavis S, Makrievski S, Patton CD
… +4 more, Alhuarrat M, Mangeshkar S, Faillace R, Grushko M
Am Heart J Plus
· 2026 Jun · PMID 42164919
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INTRODUCTION: Prosthetic valve endocarditis (PVE) is a known complication of prosthetic valve implantation (PVI). Native valve endocarditis (INVE) without concurrent PVE, or isolated native valve endocarditis (INVE), aft...INTRODUCTION: Prosthetic valve endocarditis (PVE) is a known complication of prosthetic valve implantation (PVI). Native valve endocarditis (INVE) without concurrent PVE, or isolated native valve endocarditis (INVE), after PVI is largely unheard of in literature. This review aims to identify the factors that predispose to INVE along with management and complications of INVE. METHODS: A review of four major databases was carried out to identify the incidence of INVE after various PVIs. INVE was compared to PVE in terms of patient demographics, PVI characteristics, pathogen types, management approaches, and outcomes. RESULTS: INVE was found in 119/645 (18.4%) cases after transcatheter aortic valve implantation (TAVI) and 9/138 (6.5%) cases after surgical aortic valve implantation (SAVI). INVE case distributions in the TAVI cohort were 87/119 (73.1%) on mitral valves and 32/119 (26.9%) on right heart valves. Corevalve implants were more closely linked to INVE than to transcatheter aortic valve implant endocarditis (TAVIE) at 67/119 (56.3%) vs 240/526 (45.6%) (OR = 1.55, CI 1.02-2.29, = 0.036). Surgery was performed less frequently in INVE than TAVIE at 9/119 (7.6%) vs 130/526 (24.7%) (RR = 0.31, CI 0.16-0.58, = 0.001). In hospital mortalities were less frequent in INVE than TAVIE at 22/119 (18.5%) vs 170/526 (32.3%) (RR 0.65, CI 0.45-0.94, = 0.015). CONCLUSION: INVE makes up a measurable proportion of endocarditis cases after TAVI and frequently manifests on mitral valves. Compared to TAVIE, INVE is more likely to occur after Corevalve PVI, is amenable to medical therapy, and has lower rate of in hospital mortality. Surgical and non-aortic PVI based INVE is less frequently reported on and warrants investigation.
Greene SJ, Bali V, Coyle C
… +9 more, Obi EN, Stevenson AS, Done N, Nason I, Song Y, Shen P, Zhu A, Signorovitch J, Dunbar SB
Am Heart J Plus
· 2026 Jun · PMID 42111960
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For patients with heart failure with reduced ejection fraction (HFrEF), identifying factors associated with lower uptake of guideline-directed medical therapy (GDMT) and higher rates of hospitalizations may inform strate...For patients with heart failure with reduced ejection fraction (HFrEF), identifying factors associated with lower uptake of guideline-directed medical therapy (GDMT) and higher rates of hospitalizations may inform strategies to improve quality of care. This study assessed the impact of psychosocial and socioeconomic factors on GDMT use and healthcare resource utilization among patients newly diagnosed with HFrEF between 01/01/2017-09/30/2021, in inpatient or outpatient settings across the U.S. Patients were identified from Optum's de-identified Clinformatics® Data Mart Database. GDMT improvement was defined as (1) initiation of ≥2 new GDMT classes among patients on ≤1 class, or (2) addition of ≥1 new GDMT class among patients already on ≥2 GDMT classes, within one month after the initial encounter with a new HFrEF diagnosis (the 'GDMT improvement period'). Adjusted logistic and negative binomial regressions were used to evaluate associations. The study included 230,664 patients newly diagnosed with HFrEF. For individual GDMTs, utilization rates increased by the end of the GDMT improvement period compared to baseline, but only 12.5% of patients met the definition of GDMT improvement. Psychosocial factors-including depression and substance abuse-were linked to lower odds of GDMT improvement and significantly higher rates of hospitalizations. In contrast, socioeconomic factors like household income and education levels were inversely associated with hospitalization rates but had weaker associations with GDMT improvement. In this US cohort of patients newly diagnosed with HFrEF, there was minimal initiation of GDMT after HFrEF diagnosis. Psychosocial factors were independently associated with lower GDMT uptake and higher risk of hospitalization.
Shukla K, Natalie A, Peters M
… +1 more, Bracewell N
Am Heart J Plus
· 2026 Jun · PMID 42093755
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Cardiology has undergone an impressive transformation from the initial anatomical observations of William Harvey to the current data-driven precision medicine. This review highlights the major milestones that have define...Cardiology has undergone an impressive transformation from the initial anatomical observations of William Harvey to the current data-driven precision medicine. This review highlights the major milestones that have defined the field's evolution along key discoveries, technologies, and clinical trials that have led to evidence-based cardiovascular care. Cardiovascular disease is the number one cause of death worldwide. Procedural breakthroughs such as coronary artery bypass grafting, percutaneous coronary intervention, and transcatheter valve replacement have transformed management of major adverse cardiovascular events. Simultaneously, landmark clinical trials have led to evidence-based therapies for hypertension, heart failure, and ischemic heart disease. Through synthesizing historical progress and contemporary innovations, this review underscores the transition of cardiology into a discipline that both prolongs and improves quality of life. Through appreciating important milestones, this review provides perspective for the next frontiers in cardiology: integrating artificial intelligence, promoting precision medicine, and genomics.
Poudel B, Wang Z, Shimbo D
… +8 more, Schwartz JE, Reynolds K, Harrison TN, Cannavale KL, Wei R, Muntner P, Bowling CB, Levitan EB
Am Heart J Plus
· 2026 Jun · PMID 42088636
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BACKGROUND: Concerns about hypotension and excessive blood pressure (BP) variability leading to falls may be a barrier to achieving BP treatment goals among older adults. Home BP monitoring (HBPM) may allow for better BP...BACKGROUND: Concerns about hypotension and excessive blood pressure (BP) variability leading to falls may be a barrier to achieving BP treatment goals among older adults. Home BP monitoring (HBPM) may allow for better BP management while avoiding falls. METHODS: Participants, aged ≥65 years taking antihypertensive medication ( = 541), were instructed in proper HBPM technique and asked to take 2 morning and 2 evening readings for 7 days. Among 499 participants with ≥4 days of HBPM, white coat effect was defined as mean clinic BP minus mean BP on HBPM. Day-to-day variability was calculated using standard deviation independent of the mean (SDIM). Participants reported falls monthly for 1 year. We estimated hazard ratios (HRs) for falls across quartiles of systolic BP on HBPM, white coat effect and SDIM, separately, adjusting for demographic characteristics and chronic conditions. RESULTS: The mean ± SD age of participants was 74.2 ± 6.1 years, and 57.3% were women. Prefrailty and frailty prevalence were 50.7% and 3.4%, respectively. Participants in the highest versus lowest quartile of mean SBP from HBPM were older and more frequently male. Over 379 person-years, 187 participants reported falls. Comparing the highest and lowest quartiles, the HRs (95% confidence interval) were 0.85 (0.53-1.37), 0.84 (0.51-1.40), and 0.97 (0.62-1.51) for mean systolic BP, white coat effect, and SDIM, respectively. There was no evidence of associations between these measures for diastolic BP and falls. CONCLUSION: BP measured using HBPM was not associated with falls among older US adults with treated hypertension.
Hanya S, Yamakage H, Kondoh Y
… +1 more, Sugawara M
Am Heart J Plus
· 2026 May · PMID 42064449
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STUDY OBJECTIVE: To evaluate whether impaired ventriculo-aretrial interaction characterizes chronic ischemic heart disease (CIHD) caused by stable chronic obstructive coronary artery disease (CAD), using wave intensity a...STUDY OBJECTIVE: To evaluate whether impaired ventriculo-aretrial interaction characterizes chronic ischemic heart disease (CIHD) caused by stable chronic obstructive coronary artery disease (CAD), using wave intensity and aortic pressure-velocity (PU) loop analyses. DESIGN: Retrospective observational study. SETTING: Single-center invasive hemodynamic assessment using high-fidelity multisensor catheters. PARTICIPANTS: Thirty-one patients with CIHD, including 21 with chronic atherosclerotic CAD and 10 with non-CAD CIHD. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Wave intensity-derived indices of ventriculo-arterial interaction, including the initial PU-loop slope (S1), second ascending slope (S2), backward compression wave (BCW), midsystolic forward compression wave (m-FCW), and their relative magnitudes. Discriminatory ability for CAD was assessed using receiver operating characteristic (ROC) curve analysis. RESULTS: In CAD patients, midsystolic flow was supported by a previously unreported m-FCW that emerged in response to an early-onset BCW during ventricular acceleration, reflected by higher S2 values. In contrast, midsystolic flow in non-CAD CIHD patients was primarily maintained by blood inertia and lower S1 values. S2 strongly correlated with the relative magnitude of m-FCW ( = -0.936, < 0.001). The relative magnitude of m-FCW showed greater discriminatory ability for CAD than BCW (AUC 0.976 vs. 0.771). The S2:S1 ratio correlated closely with the relative magnitude of m-FCW and demonstrated the highest AUC (0.986). CONCLUSIONS: Chronic atherosclerotic CAD is characterized by impaired ventriculo-aortic interaction, with midsystolic flow dependent on compensatory m-FCW rather than blood inertia. Aortic PU-loop parameters, particularly the S2:S1 ratio, may provide a potential diagnostic marker for distinguishing chronic atherosclerotic CAD from other forms of CIHD.
Baharvand F, Dadras M, Salari A
… +5 more, Parvaneh S, Ashouri A, Mirrazeghi F, Aris A, Jenab Y
Am Heart J Plus
· 2026 May · PMID 42058321
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BACKGROUND: Guidelines do not recommend routine glycoprotein IIb/IIIa inhibitors (GPIs), reserving them for high thrombotic-risk or bailout cases. Most acute coronary syndrome (ACS) patients undergoing percutaneous coron...BACKGROUND: Guidelines do not recommend routine glycoprotein IIb/IIIa inhibitors (GPIs), reserving them for high thrombotic-risk or bailout cases. Most acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) are already on dual antiplatelet therapy (aspirin plus clopidogrel). GPIs thus act as adjunctive therapy, providing short-term platelet inhibition. The optimal strategy, bolus-only versus bolus-plus-infusion, remains uncertain, especially in patients at higher bleeding risk. OBJECTIVE: To evaluate whether bolus-only eptifibatide provides ischemic protection comparable to standard bolus-plus-infusion while reducing bleeding in ACS patients undergoing PCI. METHODS: In this open-label, randomized trial, 183 ACS patients on aspirin and clopidogrel undergoing PCI received bolus-only eptifibatide (Group A, = 102) or bolus plus continuous infusion (Group B, = 81) and were followed for 90 days. The primary outcome, major adverse cardiac events (MACE), included cardiac death, recurrent myocardial infarction, stent thrombosis, or repeat target-vessel revascularization. Secondary endpoints included left ventricular function, mechanical/electrical complications, and bleeding. Major bleeding was defined by TIMI criteria; minor bleeding included clinically apparent non-life-threatening events. RESULTS: MACE rates were similar (2.0% vs. 2.5%; = 0.87). No major bleeding occurred. Left ventricular ejection fraction improved in both groups without significant difference ( = 0.52). Minor bleeding was lower in the bolus-only group (1.0% vs. 8.6%; = 0.02). Electrical complications were infrequent and comparable. CONCLUSIONS: In ACS patients on dual antiplatelet therapy, bolus-only eptifibatide provides ischemic protection comparable to bolus-plus-infusion while reducing minor bleeding, supporting a simplified adjunctive strategy in high thrombotic-risk patients undergoing PCI.
Sumitomo NF, Ishii T, Uchida K
… +12 more, Hosokawa S, Ishizaki R, Furutani Y, Ishida H, Takatsuki S, Inai K, Kogaki S, Fukushima H, Tamura Y, Yamagishi H, Doi S, Japanese Association of Congenital Heart Disease Registry (JACPHR) members
Am Heart J Plus
· 2026 May · PMID 42028443
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BACKGROUND: Post-operative pulmonary hypertension (PH) following biventricular repair of congenital heart disease (CHD) remains a high-risk condition, but its prognosis and risk stratification are poorly defined. This st...BACKGROUND: Post-operative pulmonary hypertension (PH) following biventricular repair of congenital heart disease (CHD) remains a high-risk condition, but its prognosis and risk stratification are poorly defined. This study aimed to identify prognostic factors and develop a simple clinical risk score. METHODS: Patients with post-operative PH enrolled in the Japan CHD-Pulmonary Hypertension Registry (2021-2024) were analyzed. Continuous and categorical variables were assessed by log-rank testing, and a composite risk score was developed to predict cardiovascular events. Prognostic performance was evaluated by Kaplan-Meier and Cox regression analyses. RESULTS: Among 84 patients (median age 11.6 years; 55% men), eight cardiovascular events occurred during a mean follow-up of 18.2 months: three all-cause deaths, three hospitalizations for heart failure, and two cases of worsening functional class. Mean pulmonary artery pressure ≥30 mmHg, pulmonary vascular resistance index ≥4.0 WU·m, B-type natriuretic peptide ≥40 pg/mL or NT-proBNP ≥300 pg/mL, and WHO functional class ≥III were significant prognostic factors. An equal-weighted score (0-4 points) stratified patients into low- (0-1), moderate- (2-3), and high-risk (4) groups with distinct survival (hazard ratio, 3.61; <0.001). CONCLUSIONS: This nationwide, registry-based study provides new insights into prognostic determinants and risk stratification in patients with post-operative PH. This study identified practical prognostic factors and proposed a simple, exploratory equal-weighted risk score. Prognostic significance was evident even at thresholds below conventional criteria, highlighting the vulnerability of this population and supporting the score's potential clinical utility pending external validation.
Am Heart J Plus
· 2026 May · PMID 42028442
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OBJECTIVE: To examine the associations of phenotypic age acceleration (PAA) with all-cause and cardiovascular mortality among U.S. adults at risk for heart failure. METHODS: We analyzed 19,665 participants aged ≥20 years...OBJECTIVE: To examine the associations of phenotypic age acceleration (PAA) with all-cause and cardiovascular mortality among U.S. adults at risk for heart failure. METHODS: We analyzed 19,665 participants aged ≥20 years at risk for heart failure from the National Health and Nutrition Examination Survey (NHANES) 1999-2010 and 2015-2018. PAA was defined as the residual from regressing phenotypic age on chronological age. Kaplan-Meier analysis, weighted Cox regression, Fine-Gray competing-risk models, and restricted cubic spline analyses were used to evaluate these associations. RESULTS: Compared with the lowest quartile, participants in the highest quartile of PAA had higher risks of all-cause mortality (HR, 2.63; 95% CI, 2.31-2.98) and cardiovascular mortality (HR, 2.55; 95% CI, 2.00-3.25). Restricted cubic spline analysis showed a nonlinear association between PAA and all-cause mortality (P for nonlinearity = 0.005), with a threshold at PAA = -8.26, whereas the association with cardiovascular mortality was linear (P for nonlinearity = 0.881). In competing-risk analysis, the highest PAA quartile remained significantly associated with increased cardiovascular mortality (SHR, 1.39; 95% CI, 1.15-1.68). CONCLUSION: Higher PAA was significantly associated with increased risks of all-cause and cardiovascular mortality among adults at risk for heart failure, suggesting that PAA may be a potential marker of mortality risk.
Cardiol Res Pract
· 2026 · PMID 42017137
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INTRODUCTION: Fasting blood glucose and myocardial infarction share some common pathophysiological risk factors, but the exact relationship between them remains unclear. This study aims to provide evidence for the associ...INTRODUCTION: Fasting blood glucose and myocardial infarction share some common pathophysiological risk factors, but the exact relationship between them remains unclear. This study aims to provide evidence for the association between fasting blood glucose and myocardial infarction by analyzing data from the National Health and Nutrition Examination Survey (NHANES) 2015-2018 and Mendelian randomization (MR) analysis. METHODS: A two-sample MR study was conducted to explore the causal relationship between fasting blood glucose and myocardial infarction using summary statistics from genome-wide association studies (GWAS). The inverse variance weighted (IVW) method and other supplementary MR methods were mainly used to verify the causal association, and sensitivity analysis was performed to confirm the robustness of the results. In addition, weighted multivariable adjusted logistic regression analysis was used to evaluate the relationship between fasting blood glucose and the myocardial infarction-related multivariable association model constructed with HDL as the core indicator based on NHANES data from 2015 to 2018. RESULTS: A total of 4807 participants were included in the observational study based on NHANES data. Weighted multivariable adjusted logistic regression analysis showed a positive correlation between fasting blood glucose and the myocardial infarction model, with an odds ratio (OR) of -0.027 and a 95% confidence interval (CI) of [-0.042, -0.011]. MR analysis also indicated a causal relationship between myocardial infarction and fasting blood glucose (IVW: OR = 1.0026, 95% CI = 1.0006-1.0046, = 0.0098). Sensitivity analysis further confirmed the robustness and reliability of these study results (all > 0.05). CONCLUSION: There is a causal relationship between fasting blood glucose and myocardial infarction.
Kornfehl A, Brock R, Oppenauer J
… +13 more, Eibensteiner F, Veigl C, Neymayer M, Valentova K, Lipa AJ, Müller M, Dreier T, Verdonck P, Mucher P, Perkmann T, Haslacher H, Schlager O, Schnaubelt S
Am Heart J Plus
· 2026 May · PMID 42016468
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OBJECTIVE: D-dimer testing is commonly used in emergency departments (EDs) to rule out thromboembolic events. However, elevated D-dimer levels may also be associated with an increased risk of mortality, independent of th...OBJECTIVE: D-dimer testing is commonly used in emergency departments (EDs) to rule out thromboembolic events. However, elevated D-dimer levels may also be associated with an increased risk of mortality, independent of thromboembolism. METHODS: This prospective observational study enrolled acutely ill medical ED patients. D-dimer measurements were conducted as part of biobanking at ED presentation. Survival at 30, 90, and 360 days was analyzed in relation to D-dimer, and Receiver operating characteristic (ROC) curves and logistic regressions were performed. RESULTS: A total of 1035 patients were included (56% male; 61 years [IQR 46-74]). Median follow-up was 764 days (7.7% mortality). Elevated D-dimer (≥0.5 μg/mL) was observed in 46.4% of patients. Thirty-day mortality was 4.8% in patients with elevated D-dimer versus 0.2% with normal D-dimer levels (log-rank < 0.001), while 360-day mortality was 13.5% versus 2.3% ( < 0.001), respectively. Among discharged patients, 360-day mortality was 9.2% with elevated D-dimer vs. 0.7% with normal values (log-rank p < 0.001).The ROC-derived optimal cut-off for both time points was 0.75 μg/mL (AUC 0.82 and 0.76 for 30- and 360-day mortality). Multivariable analysis adjusted for age, BMI, and comorbidities yielded elevated D-dimer to remain an independent predictor of mortality. CONCLUSION: In unselected ED patients, D-dimer independently predicts 30- and 360-day mortality. Beyond its diagnostic role for VTE, an elevated D-dimer-particularly in patients with no VTE and discharge from the ED-identifies individuals at increased short- and long-term risk. Incorporating D-dimer (e.g., ≥ 0.75 μg/mL) into routine risk stratification may support targeted follow-up and post-discharge management.
Simeone P, Liani R, Lattanzio S
… +4 more, Frezza M, Alfonsetti M, Cipollone F, Santilli F
Am Heart J Plus
· 2026 May · PMID 42016467
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Oxidative stress (OS), derived from an imbalance between reactive oxygen species (ROS) accumulation and impaired antioxidant defense, is a recognized cause of atherothrombosis, through a complex interaction between low-g...Oxidative stress (OS), derived from an imbalance between reactive oxygen species (ROS) accumulation and impaired antioxidant defense, is a recognized cause of atherothrombosis, through a complex interaction between low-grade inflammation and platelet activation. Lipid peroxidation, as reflected by the urinary excretion of 8-iso-Prostaglandin F2α (8-iso-PGF), is central in the pathogenesis of atherosclerosis. This biochemical abnormality has been observed in patients with cardiovascular risk factors, including diabetes mellitus, obesity, cigarette smoking, hypercholesterolemia, hypertension, atrial fibrillation, and in clinical settings associated with aging, such as acute and chronic cardiovascular diseases and chronic kidney disease. Despite the treatment with acetylsalicylic acid or with any other antithrombotic drugs, patients may undergo recurrent events due to the complex nature of atherothrombosis. A large body of evidence supports the relationship between OS and less-than-expected response to aspirin. Several disease-modifying agents and antioxidant supplementation, as well as modulation of the primary metabolic abnormalities driving lipid peroxidation, have been shown to reduce urinary 8-iso-PGF excretion. Overall, these observations pave the way for potential therapeutic approaches able to target these mechanisms, resulting in the reduction of atherothrombosis progression. This will be an overview of the significance of 8-iso-PGF in the pathogenesis of atherothrombosis and as a potential mechanism-based biomarker of cardiovascular events.
Pavlovic NV, Saylor MA, Himmelfarb CR
… +6 more, Lee CS, Chang PP, Matsushita K, Leoutsakos JS, Shah AM, Ndumele CE
Am Heart J Plus
· 2026 May · PMID 42007011
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Fatigue, as well as echocardiographic indices of cardiac structure and function, are both associated with adverse outcomes in heart failure (HF). However, the relationship of fatigue and echocardiographic assessments hav...Fatigue, as well as echocardiographic indices of cardiac structure and function, are both associated with adverse outcomes in heart failure (HF). However, the relationship of fatigue and echocardiographic assessments have not yet been fully characterized. In this analysis of 851 individuals with prevalent HF in the Atherosclerosis Risk in Communities Study, echocardiographic measures of cardiac structure and function were not associated with general and exertional fatigue. Furthermore, fatigue symptoms provided complementary prognostic information to that provided by echocardiographic assessments.
He Z, Xiong W, Li Y
… +5 more, Wu X, Zhang Y, Shan X, Liu Y, Rang W
Am Heart J Plus
· 2026 May · PMID 42007008
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OBJECTIVE: This study aimed to investigate the association of body roundness index (BRI) with all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3. METHODS: We...OBJECTIVE: This study aimed to investigate the association of body roundness index (BRI) with all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3. METHODS: We analyzed data from 18,984 participants in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. We employed Cox proportional hazards models, Fine-Gray proportional subdistribution hazards models, restricted cubic splines (RCS), and subgroup analysis to examine the associations between BRI and all-cause and cardiovascular mortality in patients with CKM syndrome stages 0-3. RESULTS: Over a median follow-up of 7.5 years, 1756 all-cause and 471 cardiovascular deaths were documented. Cox and Fine-Gray models revealed a significant positive association between the BRI and both all-cause and cardiovascular mortality after full adjustment. RCS indicated a U-shaped nonlinear relationship between BRI and all-cause mortality ( for nonlinear <0.0001), while a linear association was observed with cardiovascular mortality ( for nonlinear = 0.0635). Threshold analysis identified an inflection point at BRI = 5.68. BRI levels below 5.68 showed a negative correlation (HR = 0.90, 95% : 0.83-0.96, = 0.0024); above 5.68 BRI was positively correlated (HR = 1.12, 95% : 1.08-1.17, < 0.0001). Subgroup analyses revealed significant interactions ( for interaction <0.05) whereby the association was strongest among participants with less than high school diploma and current drinkers (for all-cause mortality), and among younger participants(< 50 years) and current smokers (for cardiovascular mortality). CONCLUSION: In CKM syndrome stages 0-3, BRI shows a U-shaped link to all-cause mortality but a linear association with cardiovascular mortality.